Sustainable and modular packaging system for containers for pharmaceutical use

Abstract

Systems for packaging containers are disclosed. The systems include a carton having a storage configuration and an assembled configuration, in the storage configuration, the carton is substantially flat. The carton includes a bottom box, a lid coupled to the bottom box, a first flap extending from a first side wall of the bottom box, and a second flap extending from a second side wall of the bottom box. The first flap and the second flap define a set of cavities. The systems also include an insert configured to be disposed within the bottom box of the carton. The insert has a storage configuration and an assembled configuration, in the storage configuration, the insert is substantially flat. The insert defines at least one cavity sized to receive at least one container.

Description

[0001] Cross-reference to related applications

[0002] This application claims priority to U.S. Provisional Patent Application No. 63 / 559,377, filed February 29, 2024, the entire contents of which are incorporated herein by reference. Technical Field

[0003] This disclosure generally relates to packaging systems for containers used in clinical, medical, or pharmaceutical applications, and more specifically to sustainable and modular systems for packaging containers (such as glass vials) used in clinical, medical, or pharmaceutical applications. Background Technology

[0004] Containers (such as glass vials) are commonly used in the medical and pharmaceutical fields to contain various quantities of medications. These containers are frequently transported from one location to another, especially when they are manufactured in one location, filled in another, and used in yet another. When transporting containers from one location to another, they are typically grouped together in packaging systems (such as pallets and / or boxes) manually or by automated means. For example, sterile glass vials containing medications are placed in a box and then sealed. Upon arrival at their destination, the box is opened to allow each container to be removed and used subsequently.

[0005] The industry uses pallets and / or boxes for packaging and transporting pharmaceutical containers, such as glass vials. However, conventional packaging systems do not provide sufficient protection against lateral impacts between each container, thus preventing damage or breakage to containers typically made of fragile materials such as glass. Furthermore, conventional packaging systems do not protect containers from top-load impacts (especially when packages are stacked vertically) or bottom impacts (especially when packages are placed on hard surfaces). Therefore, containers transported using these conventional packaging systems are prone to damage or breakage.

[0006] In addition, the International Organization for Standardization (ISO) has established standard dimensions and capacities for injectable containers, such as glass vials. For example, ISO 8362-1 specifies the standard capacities for injectable vials made of glass. According to ISO 8362-1, the full capacity of a 2R vial is 4 cc (4 ml), a 6R vial is 10 cc (10 ml), and a 10R vial is 13.5 cc (13.5 ml). ISO 8362-1 also specifies the standard dimensions for glass vials. For example, ISO 8362-1 specifies that the outer diameter of a 2R glass vial is 16 mm ± 0.15 mm and the height is 35 mm ± 0.5 mm, the outer diameter of a 6R vial is 22 mm ± 0.2 mm and the height is 40 mm ± 0.5 mm, and the outer diameter of a 10R vial is 24 mm ± 0.2 mm and the height is 45 mm ± 0.5 mm.

[0007] Because conventional packaging systems have fixed dimensions and sizes, and because ISO 8362-1 establishes standard dimensions for containers (such as glass vials), conventional packaging systems may only allow containers of one size (e.g., height, outer diameter) to be grouped into corresponding packages. For example, due to differences in standard vial sizes, conventional boxes for packaging pharmaceuticals do not allow ISO 2R and 4cc vials to be grouped with ISO 6R, ISO 10R, or 10cc vials in the same box. Therefore, conventional packaging systems do not offer flexibility in use, as multiple containers of different sizes are not suitable for packaging together in one system. This limitation can directly affect the number of containers that can be packaged into each system. This limitation can also directly affect the number of packaging systems required to transport a given number of containers, and thus the cost of transporting containers from one location to another.

[0008] In addition, conventional packaging systems that attempt to protect containers from damage typically include foam inserts or plastic pallets. Foam inserts and plastic pallets prevent containers from contacting each other and thus provide protection against lateral impacts. However, materials such as foam or plastic are unsustainable and harmful to the environment.

[0009] This disclosure describes systems that embody advantageous alternatives to existing systems for packaging multiple containers for clinical, medical, or pharmaceutical use, and that address one or more of the challenges or needs mentioned herein, while providing additional benefits and advantages. Summary of the Invention

[0010] One aspect of this disclosure provides a system for packaging one or more containers. The system may include a carton having a storage configuration and an assembly configuration, in which the carton is substantially flat. The carton may include a bottom body having a first bottom wall, a first side wall, a second side wall, a first rear wall, and a first front wall when the carton is in the assembly configuration. The carton may further include: a lid coupled to the bottom body and movable between an open position and a closed position; a first flap extending from the first side wall of the bottom body; and a second flap extending from the second side wall of the bottom body. The second side wall may be opposite to and facing the first side wall, and the first flap and the second flap may define a set of cavities. The system may further include an insert configured to be disposed within the bottom body of the carton. The insert may have a storage configuration and an assembly configuration, in which the insert is substantially flat. The insert may define at least one cavity, the cavity being sized to receive at least one container. In this assembly configuration, the insert may include a top wall, a second bottom wall, a second rear wall, a second front wall defining the at least one cavity, and an intermediate wall positioned between the top wall and the second bottom wall.

[0011] In some embodiments, the insert may define: a first cavity sized to receive a first container; and a second cavity sized to receive a second container. In some embodiments, the diameter of the first cavity may be smaller than the diameter of the second cavity, and the diameter of the first container may be smaller than the diameter of the second container. In some embodiments, when the at least one container is received in the at least one cavity, the bottom surface of the at least one container may be configured to abut an intermediate wall of the insert.

[0012] In some embodiments, the carton may further include a release tab that includes a portion of at least one of the lid and the bottom housing, and is defined by a perforated line in at least one of the lid and the bottom housing. When the lid is in the closed position, the release tab may be secured to at least one of the lid and the bottom housing via the perforation. When the lid is in the open position, the release tab may be disengaged from at least one of the lid and the bottom housing along the perforated line. In some embodiments, the release tab may be a push tab that removes the release tab from at least one of the lid and the bottom housing. In some embodiments, the system may further include an adhesive positioned on at least a portion of the release tab, and the release tab may include a kiss-shaped cut to improve the fixation between the release tab and the adhesive.

[0013] In some embodiments, when the insert is disposed within the bottom housing of the cardboard box, the second bottom wall may be configured to abut the first bottom wall, the second rear wall may be configured to abut the first rear wall, and the second front wall may be configured to abut the first front wall. In some embodiments, the at least one container may include a vial. The vial may be one of the following: ISO 2R vials, ISO 6R vials, ISO 10R vials, ISO 20R vials, or ISO 50R vials. In other embodiments, the first container may be one of the following: ISO 2R vials, ISO 6R vials, ISO 10R vials, ISO 20R vials, or ISO 50R vials, and the second container may be a different one of the following: ISO 2R vials, ISO 6R vials, ISO 10R vials, ISO 20R vials, or ISO 50R vials. In some embodiments, the vial may be filled with or pre-filled with a drug. The drug may include talataumarin. In some embodiments, the cardboard box and the insert may be made of cardboard or a combination of synthetic and natural materials.

[0014] Another aspect of this disclosure provides a system for packaging multiple containers. The system may include a carton having a storage configuration and an assembly configuration, in which the carton is substantially flat. The carton may include a bottom body having a first bottom wall, a first side wall, a second side wall, a first rear wall, and a first front wall when the carton is in the assembly configuration. The carton may further include: a lid coupled to the bottom body and movable between an open position and a closed position; a tray coupled to the bottom body and movable between a first position and a second position; a first flap extending from the first side wall of the bottom body; and a second flap extending from the second side wall of the bottom body. The second side wall may be opposite to and facing the first side wall. The system may further include an insert configured to be disposed within the bottom body of the carton. The insert may have a storage configuration and an assembly configuration, in which the insert is substantially flat. The insert may define multiple cavities, and each cavity may be sized to receive a corresponding one of a plurality of containers. In this assembly configuration, the insert may include a top wall, a second bottom wall, a third side wall, a fourth side wall, a second rear wall, a second front wall, and a first intermediate wall positioned between the top wall and the second bottom wall. The top wall and the first intermediate wall may define the plurality of cavities.

[0015] In some embodiments, the tray may be configured to define a second bottom housing within the bottom housing when the tray is in the second position. In some embodiments, the insert may further include a first pair of opposing flaps coupled to the second front wall and a second pair of opposing flaps coupled to the second rear wall. The insert may also include a third pair of opposing flaps coupled to the top wall, and the third pair of opposing flaps may be movable between an open position and a closed position. In the closed position, the third pair of opposing flaps may define a third sidewall and a fourth sidewall of the insert.

[0016] In some embodiments, when the insert is disposed within the bottom housing of the cardboard box, the second bottom wall may be configured to abut the first bottom wall, the third side wall may be configured to abut the first side wall, the fourth side wall may be configured to abut the second side wall, the second rear wall may be configured to abut the first rear wall, and the second front wall may be configured to abut the first front wall. In some embodiments, the insert may further include a second intermediate wall positioned between the first intermediate wall and the second bottom wall. When the plurality of containers are received within the plurality of cavities, at least one of the first intermediate wall or the second intermediate wall may be configured to abut the bottom surface of the plurality of containers.

[0017] In some embodiments, the insert may further include a vertical rib support extending between the second intermediate wall and the second bottom wall, and the vertical rib support may be configured to maintain a predefined distance between the second intermediate wall and the second bottom wall. In some embodiments, the number of cavities defined by the top wall may be different from the number of cavities defined by the first intermediate wall. In other embodiments, the number of cavities defined by the top wall may be equal to the number of cavities defined by the first intermediate wall. In some embodiments, each of the plurality of cavities may have equal dimensions. In other embodiments, at least one of the plurality of cavities may have a different dimension than the remaining cavities.

[0018] In some embodiments, the carton may further include a release tab, which is a portion of at least one of the lid and the bottom housing, and may be defined by a perforated line in at least one of the lid and the bottom housing. When the lid is in the closed position, the release tab may be secured to at least one of the lid and the bottom housing via the perforation. When the lid is in the open position, the release tab may be disengaged from at least one of the lid and the bottom housing along the perforated line. In some embodiments, the release tab may be a push tab that removes the release tab from at least one of the lid and the bottom housing. In some embodiments, the system may further include an adhesive positioned on at least a portion of the release tab, and the release tab may include a kiss-shaped cut to improve the fixation between the release tab and the adhesive.

[0019] In some embodiments, at least one of the plurality of containers may include a vial. The vial may be one of the following: ISO 2R vials, ISO 6R vials, ISO 10R vials, ISO 20R vials, or ISO 50R vials. In some embodiments, the plurality of containers may include a first vial and a second vial. The first vial may be one of the following: ISO 2R vials, ISO 6R vials, ISO 10R vials, ISO 20R vials, or ISO 50R vials, and the second vial may be a different one of the following: ISO 2R vials, ISO 6R vials, ISO 10R vials, ISO 20R vials, or ISO 50R vials. In some embodiments, the vial may be filled or pre-filled with a drug, and the drug may include talataumarin. In some embodiments, the carton and the insert may be made of cardboard or a combination of synthetic and natural materials.

[0020] Another aspect of this disclosure provides a system for packaging multiple containers. The system may include a carton having a storage configuration and an assembly configuration, in which the carton is substantially flat. The carton may include a plurality of sidewalls, a top wall, a bottom wall, a first flap extending from a first sidewall of the plurality of sidewalls, and a second flap extending from a second sidewall of the plurality of sidewalls, the second sidewall being opposite to and facing the first sidewall. The first flap and the second flap define a first set of cavities. The system also includes an insert configured to be disposed within the carton, and the insert having a storage configuration and an assembly configuration, in which the insert is substantially flat. In the assembly configuration, the insert includes a first layer, a second layer positioned at a first distance below the first layer, and a third layer positioned at a second distance below the second layer. The first layer includes at least one opening configured to receive the container and a first set of flaps extending from the opposite side of the first layer, and the second layer is configured to support the bottom surface of the container and includes a second set of flaps extending from the opposite side of the second layer. The first set of flaps of the first layer and the second set of flaps of the second layer are configured to fold downwards.

[0021] In some embodiments, in this assembly configuration, the carton may include four side walls, the top wall, and the bottom wall, and at least the four side walls and the bottom wall may define a second cavity inside the carton. The second cavity inside the carton may be configured to receive the insert. In this assembly configuration, the insert may include two opposing side walls connecting the first layer, the second layer, and the third layer. In some embodiments, when the insert is in this assembly configuration, the first set of flaps of the first layer and the second set of flaps of the second layer may be configured to fold downward to define two additional side walls of the insert. In some embodiments, when the insert is in this assembly configuration and disposed within the carton, the inner surface of the first set of flaps of the first layer may be configured to abut the outer surface of the second set of flaps of the second layer, and the outer surface of the first set of flaps of the first layer may be configured to abut the inner surfaces of two of the four side walls of the carton.

[0022] In some embodiments, the first set of cavities may include generally rectangular air cavities, and the first set of cavities may be configured to provide a distance between the top wall of the carton and the top surface of the container to protect the container from top loads. In this assembly configuration, the insert may include two opposing sidewalls connecting the first layer, the second layer, and the third layer, and in this assembly configuration, a first set of flaps of the first layer and a second set of flaps of the second layer may be configured to fold downwards to define two additional sidewalls of the insert. In some embodiments, the first layer, the second layer, the third layer, the two opposing sidewalls connecting the first layer, the second layer, and the third layer, and the two additional sidewalls of the insert may be integrally formed.

[0023] In some embodiments, when the insert is disposed within the cardboard box, the second layer of the insert can be raised by the second distance from the third layer of the insert, such that the bottom surface of the container is raised by the second distance from the bottom wall of the cardboard box. In some embodiments, the plurality of side walls, top wall, bottom wall, first flap, and second flap of the cardboard box can be integrally formed. In some embodiments, the container can be a vial, and the vial can be one of an ISO 2R vial, an ISO 6R vial, an ISO 10R vial, an ISO 20R vial, or an ISO 50R vial.

[0024] Another aspect of this disclosure provides a system for packaging multiple containers. The system may include a carton having a storage configuration and an assembly configuration, in which the carton is substantially flat. The carton may include a plurality of sidewalls, a top wall, a bottom wall, a first flap extending from a first sidewall of the plurality of sidewalls, and a second flap extending from a second sidewall of the plurality of sidewalls, the second sidewall being opposite to and facing the first sidewall. The first flap and the second flap define a first set of cavities. The system also includes an insert configured to be disposed within the carton, and the insert having a storage configuration and an assembly configuration, in which the insert is substantially flat. In the assembly configuration, the insert includes a first layer, a second layer positioned at a first distance below the first layer, a third layer positioned at a second distance below the second layer, and a fourth layer positioned at a third distance below the third layer. The first layer includes a first set of holes configured to receive a plurality of containers, and each hole in the first set of holes is configured to receive a first portion of a corresponding container among the plurality of containers. The first layer also includes a first set of flaps extending from the opposite side of the first layer. The second layer includes a second set of holes configured to receive the plurality of containers, and each hole in the second set of holes is configured to receive a second portion of a corresponding container among the plurality of containers. The second layer also includes a second set of flaps extending from the opposite side of the second layer. The third layer is configured to support the bottom surface of the plurality of containers, and the first set of flaps of the first layer and the second set of flaps of the second layer are configured to fold downwards.

[0025] In some embodiments, the insert may further include a vertical rib support extending between the third and fourth layers. The vertical rib support may be configured to maintain a third distance between the third and fourth layers. In other embodiments, a first set of holes in the first layer and a second set of holes in the second layer may be vertically aligned. In this assembly configuration, the carton may include four side walls, the top wall, and the bottom wall, and at least the four side walls and the bottom wall may define a second cavity inside the carton. The second cavity inside the carton may be configured to receive the insert.

[0026] In some embodiments, in this assembly configuration, the insert may include two opposing sidewalls connecting the first, second, third, and fourth layers. When the insert is in this assembly configuration, the first set of flaps of the first layer and the second set of flaps of the second layer may be configured to fold downwards to define two additional sidewalls of the insert. In some embodiments, when the insert is in this assembly configuration and disposed within the carton, the inner surface of the first set of flaps of the first layer may be configured to abut the outer surface of the second set of flaps of the second layer, and the outer surface of the first set of flaps of the first layer may be configured to abut the inner surfaces of two of the four sidewalls of the carton.

[0027] In some embodiments, the first set of cavities may include generally rectangular air cavities, and the first set of cavities may be configured to provide a distance between the top wall of the carton and the top surface of the plurality of containers to protect the plurality of containers from top loads. In this assembly configuration, the insert may include two opposing sidewalls connecting the first layer, the second layer, the third layer, and the fourth layer, and in this assembly configuration, a first set of flaps of the first layer and a second set of flaps of the second layer may be configured to fold downward to define two additional sidewalls of the insert.

[0028] In some embodiments, the first, second, third, and fourth layers of the insert, two opposing sidewalls connecting the first, second, third, and fourth layers, and two additional sidewalls may be integrally formed. In other embodiments, when the insert is disposed within the cardboard box, the third layer of the insert can be raised by a third distance from the fourth layer of the insert, such that the bottom surfaces of the plurality of containers are raised by the third distance from the bottom wall of the cardboard box. In some embodiments, the plurality of sidewalls, top wall, bottom wall, first flap, and second flap of the cardboard box may be integrally formed.

[0029] Other features of this disclosure will be apparent to those skilled in the art after considering embodiments illustrating the best mode of implementing this disclosure as now understood. Attached Figure Description

[0030] We believe that this disclosure will be more fully understood from the following description taken in conjunction with the accompanying drawings. To illustrate other elements more clearly, some drawings may be simplified by omitting selected elements. In some drawings, such omission of elements does not necessarily indicate the presence or absence of a particular element in any exemplary embodiment, unless it can be clearly indicated in the corresponding written description. Furthermore, not all drawings need to be drawn to scale.

[0031] Figure 1A Exemplary systems for packaging containers according to various embodiments of this disclosure are shown.

[0032] Figure 1B Various embodiments based on this disclosure are shown. Figure 1A Another view of an exemplary system.

[0033] Figure 1C Various embodiments based on this disclosure are shown. Figure 1A Another view of an exemplary system.

[0034] Figure 1D Various embodiments based on this disclosure are shown. Figure 1A Another view of an exemplary system.

[0035] Figure 2A Various embodiments based on this disclosure are shown. Figure 1A An exemplary cardboard box of an exemplary system.

[0036] Figure 2B Various embodiments based on this disclosure are shown. Figure 2A A top view of an exemplary cardboard box.

[0037] Figure 2C Various embodiments of the present disclosure are shown with exemplary inserts. Figure 2A An example cardboard box.

[0038] Figure 2D Various embodiments based on this disclosure are shown. Figure 2A Exemplary cardboard boxes and Figure 2C A top view of an exemplary insert.

[0039] Figure 2E Various embodiments based on this disclosure are shown. Figure 2A Exemplary cardboard boxes and Figure 2C The bottom view of an exemplary insert.

[0040] Figure 3A Various embodiments based on this disclosure are shown. Figure 2C Another view of an exemplary insert.

[0041] Figure 3B Various embodiments based on this disclosure are shown. Figure 3A A side view of an exemplary insert.

[0042] Figure 3C Various embodiments based on this disclosure are shown. Figure 3A Another side view of an exemplary insert.

[0043] Figure 3D Various embodiments based on this disclosure are shown. Figure 3A Another side view of an exemplary insert.

[0044] Figure 4A A plan view of a punched portion of an exemplary cardboard box for packaging multiple containers, illustrating various embodiments of the exemplary system according to this disclosure.

[0045] Figure 4B A plan view of a punched part of an exemplary insert for packaging multiple containers, according to various embodiments of this disclosure, is shown.

[0046] Figure 5AVarious embodiments of the present disclosure are shown in their storage configurations. Figure 4A Exemplary cardboard boxes and Figure 4B An example insert.

[0047] Figure 5B Various embodiments of the present disclosure are shown in their assembly configurations. Figure 5A Exemplary cardboard boxes and exemplary inserts.

[0048] Figure 5C Exemplary systems for packaging multiple containers in their assembled configurations, according to various embodiments of this disclosure, are shown. Figure 5B Exemplary cardboard boxes and exemplary inserts.

[0049] Figure 5D Various embodiments based on this disclosure are shown. Figure 5C Another view of an exemplary system.

[0050] Figure 5E Various embodiments based on this disclosure are shown. Figure 5C Another view of an exemplary system.

[0051] Figure 5F Various embodiments based on this disclosure are shown. Figure 5C Another view of an exemplary system.

[0052] Figure 6A Various embodiments of the present disclosure are shown in their storage configurations. Figure 5A An example cardboard box.

[0053] Figure 6B Various embodiments of the present disclosure are shown in their assembly configurations. Figure 5A An example cardboard box.

[0054] Figure 6C Various embodiments of the present disclosure are shown in their assembly configurations. Figure 5A Another view of an exemplary cardboard box.

[0055] Figure 7A Various embodiments of the present disclosure are shown in their storage configurations. Figure 5A An example insert.

[0056] Figure 7B Various embodiments of the present disclosure are shown in their assembly configurations. Figure 5A A side view of an exemplary insert.

[0057] Figure 7CVarious embodiments of the present disclosure are shown in their assembly configurations. Figure 5A Another side view of an exemplary insert.

[0058] Figure 7D Various embodiments of the present disclosure are shown in their assembly configurations. Figure 5A Another side view of an exemplary insert.

[0059] Figure 8 Various embodiments of the present disclosure are shown in their assembly configurations. Figure 5A A side plan view of an exemplary insert.

[0060] Figure 9A A plan view of a punched portion of an exemplary cardboard box for packaging multiple containers, illustrating various embodiments of the exemplary system according to this disclosure.

[0061] Figure 9B A plan view of a punched part of an exemplary insert for packaging multiple containers, according to various embodiments of this disclosure, is shown.

[0062] Figure 10A Various embodiments of the present disclosure are shown in their assembly configurations. Figure 9A Exemplary cardboard boxes and Figure 9B An example insert.

[0063] Figure 10B Exemplary systems for packaging multiple containers in their assembled configurations, according to various embodiments of this disclosure, are shown. Figure 10A Exemplary cardboard boxes and exemplary inserts.

[0064] Figure 10C Various embodiments based on this disclosure are shown. Figure 10A A three-dimensional diagram of an exemplary system.

[0065] Figure 10D Various embodiments based on this disclosure are shown. Figure 10A Another view of an exemplary system.

[0066] Figure 11 Various embodiments based on this disclosure are shown. Figure 10A A side view of an exemplary insert.

[0067] Figure 12A A plan view of a punched portion of an exemplary cardboard box, illustrating an exemplary system for packaging containers according to various embodiments of this disclosure.

[0068] Figure 12BA plan view of a punched portion of an exemplary insert for an exemplary system for packaging containers, according to various embodiments of this disclosure, is shown.

[0069] Figure 13A A perspective view of an exemplary system for packaging containers according to various embodiments of this disclosure is shown, the system having an assembled configuration. Figure 12A An exemplary cardboard box and in an assembled configuration Figure 12B An example insert.

[0070] Figure 13B Various embodiments based on this disclosure are shown. Figure 13A A cross-sectional view of an exemplary system.

[0071] Figure 13C Various embodiments of the present disclosure are shown in the assembled configuration. Figure 12B A perspective view of an exemplary insert.

[0072] Figure 14A A plan view of a punched portion of an exemplary cardboard box for packaging at least one container, according to various embodiments of this disclosure.

[0073] Figure 14B A plan view of a punched part of an exemplary insert for packaging at least one container, according to various embodiments of this disclosure, is shown.

[0074] Figure 15A A perspective view is shown of an exemplary system for packaging at least one container according to various embodiments of this disclosure, the system having an assembled configuration. Figure 14A An exemplary cardboard box and in an assembled configuration Figure 14B An example insert.

[0075] Figure 15B Various embodiments based on this disclosure are shown. Figure 15A A cross-sectional view of an exemplary system.

[0076] Figure 16A A plan view of a punched portion of an exemplary cardboard box for packaging multiple containers, illustrating various embodiments of the exemplary system according to this disclosure.

[0077] Figure 16B A plan view of a punched part of an exemplary insert for packaging multiple containers, according to various embodiments of this disclosure, is shown.

[0078] Figure 17A Various embodiments of the present disclosure are shown in the assembled configuration. Figure 16AA perspective view of an exemplary cardboard box having an exemplary tray in a first position.

[0079] Figure 17B Various embodiments based on this disclosure are shown. Figure 17A A perspective view of an exemplary cardboard box having an exemplary tray in a second position.

[0080] Figure 18A Various embodiments of the present disclosure are shown in the assembled configuration. Figure 16B A perspective view of an exemplary insert.

[0081] Figure 18B Various embodiments based on this disclosure are shown. Figure 18A A side view of an exemplary insert.

[0082] Figure 18C Various embodiments based on this disclosure are shown. Figure 18A Another side view of an exemplary insert.

[0083] Figure 18D Various embodiments based on this disclosure are shown. Figure 18A Another side view of an exemplary insert.

[0084] Figure 19A A plan view of a punched portion of an exemplary cardboard box for packaging multiple containers, illustrating various embodiments of the exemplary system according to this disclosure.

[0085] Figure 19B A plan view of a punched part of an exemplary insert for packaging multiple containers, according to various embodiments of this disclosure, is shown.

[0086] Figure 20A Various embodiments of the present disclosure are shown in the assembled configuration. Figure 19A A perspective view of an exemplary cardboard box having an exemplary tray in a first position.

[0087] Figure 20B Various embodiments based on this disclosure are shown. Figure 20A A perspective view of an exemplary cardboard box having an exemplary tray in a second position.

[0088] Figure 21A Various embodiments of the present disclosure are shown in the assembled configuration. Figure 19B A perspective view of an exemplary insert.

[0089] Figure 21B Various embodiments based on this disclosure are shown. Figure 21AA side view of an exemplary insert.

[0090] Figure 21C Various embodiments based on this disclosure are shown. Figure 21A Another side view of an exemplary insert.

[0091] Figure 21D Various embodiments based on this disclosure are shown. Figure 21A Another side view of an exemplary insert. Detailed Implementation

[0092] This disclosure generally relates to systems for packaging one or more containers for clinical, medical, or pharmaceutical use. The containers disclosed herein may include, but are not limited to, vials for containing pharmaceutical agents, such as glass vials. For example, containers may include glass vials suitable for cc vials and configured to contain pharmaceutical agents, such as lyophilized or liquid pharmaceutical products. Containers may have standard capacities and dimensions as specified in ISO 8362-1. The systems disclosed herein may include cartons and inserts. Cartons and / or inserts may include features configured to protect the container packaged within the system from physical damage or breakage in all three dimensions (e.g., protecting the container from impacts along the x, y, and z axes). Cartons and / or inserts may be transported in a storage configuration and may be folded from a storage configuration to an assembly configuration during assembly. Thus, many cartons and inserts can be stacked vertically in their storage configurations, reducing their form factor and storage footprint while improving the efficiency and cost of transporting the systems disclosed herein and storing them in a warehouse. During assembly, inserts may also be placed inside cartons to form the disclosed system. The cartons and inserts can be manufactured using fully recyclable sustainable materials, which is environmentally beneficial compared to conventional packaging systems made from plastic pallets or foam inserts. Furthermore, the inserts in the systems disclosed herein are interchangeable. Thus, the cartons can be configured to accommodate inserts for accommodating up to six containers (for example) and inserts for accommodating up to twelve containers (for example). Therefore, the systems disclosed herein can be modular, as they are capable of accommodating various numbers of containers depending on the inserts placed inside the cartons. These and other advantages and benefits will be apparent to those skilled in the art who read this disclosure.

[0093] As used herein, the term "carton" can refer to a carton used to package one or more containers. The term "container" can refer to any component that can be received, set in, and / or contained within packaging, such as vials, syringes, pre-filled syringes, etc. As used herein, the term "medicine" is used interchangeably with other similar terms and can refer to any type of pharmaceutical preparation or therapeutic material, including traditional and non-traditional medicines, nutritional supplements, tonics, biologics, bioactive agents and compositions, macromolecules, biosimilars, bioequivalents, therapeutic antibodies, peptides, proteins, small molecules, and analogues. Non-therapeutic injectable materials are also included. Pharmaceuticals may be in liquid form, lyophilized form, or in a form that can be reconstituted from lyophilization.

[0094] As discussed above, conventional systems for packaging one or more containers offer little flexibility in use because they are not suitable for accommodating multiple containers of different sizes to be packaged together in a single system. This limitation can directly affect the number of containers that can be packaged into each system. It can also directly affect the number of packaging systems required to transport a given number of containers, and thus the cost of transporting containers from one location to another. Furthermore, conventional packaging systems that attempt to protect the containers within them from damage typically include foam inserts or plastic pallets. Foam inserts and plastic pallets prevent containers from contacting each other and thus provide protection against lateral impacts. However, materials such as foam or plastic are unsustainable and environmentally harmful. Moreover, conventional packaging systems cannot protect the containers within them from top or bottom loads. For example, when conventional packaging systems are stacked vertically or placed on a hard surface, they cannot protect the containers from top loads, bottom loads, and vertical impacts.

[0095] Therefore, there is a need for an improved system for packaging one or more containers, such as glass vials, that protects the containers from vertical and lateral impacts. There is also a need for an improved system for packaging one or more containers that is not only manufactured using sustainable and environmentally friendly materials, but is also modular, allowing a single packaging system to be configured to accommodate and transport multiple container sizes and multiple container counts.

[0096] Now for reference Figures 1A to 1DThis illustration shows an exemplary system 200 for packaging container 208 according to various embodiments of this disclosure. As will be discussed in more detail below, system 200 may include a cardboard box 202 (also interchangeably referred to as a "box") and an insert 204 configured to be placed inside the cardboard box 202. Insert 204 may include a hole 206 configured to receive the container 208 therein. For example, hole 206 may be punched in insert 204, and hole 206 may be punched at the center point of insert 204 such that hole 206 is spaced apart from the sides of insert 204. By positioning hole 206 away from all sides of insert 204, insert 204 of system 200 can prevent container 208 therein from contacting the sides of system 200 during packaging or transport. Furthermore, hole 206 may be sized to accommodate containers 208 of various sizes. For example, the aperture 206 can be sized to accommodate one or more of the following: ISO 2R vials and 4 cc vials, ISO 6R vials, and ISO 10R and 10 cc vials.

[0097] In some embodiments, the cardboard box 202 and the insert 204 may be manufactured and formed separately. The cardboard box 202 and the insert 204 may be manufactured using fully recyclable sustainable materials. For example, the cardboard box 202 and the insert 204 may be made from cardboard materials or other Forest Stewardship Council (FSC) certified materials. In other embodiments, the cardboard box 202 and the insert 204 may be manufactured and formed integrally. In some embodiments, such as Figures 1A to 1C As shown, the cardboard box 202 may include multiple side walls 213, a top wall 214, and a bottom wall 216 (in... Figure 2E (As shown in the diagram) and a rear flap 215 extending from the top wall 214. The cardboard box 202 may also include a first flap 207a extending from a first sidewall 213a of a plurality of sidewalls 213, and a second flap 207b extending from a second sidewall 213b opposite to and facing the first sidewall 213a. The first flap 207a and the second flap 207b may define a first set of cavities 209, such as... Figure 1B and Figure 1C As shown. In some embodiments, the first set of cavities 209 may include generally rectangular air cavities. In other embodiments, the first set of cavities 209 may include triangular, circular, or elliptical air cavities. The first set of cavities 209 may be configured to protect the container 208 from top load impacts. For example, when the flaps 207a, 207b are folded downwards, as... Figure 1CAs shown, the first set of cavities 209 can provide air damping, such that when a top load is placed on top of the cardboard box 202, the space created within the first set of cavities 209 can be configured to dampen the container 208 and protect it from any vertical impact or damage. In some embodiments, the side wall 213, top wall 214, bottom wall 216, rear flap 215, first flap 207a, and second flap 207b can be integrally formed.

[0098] Figures 2A to 2E Showed in more detail Figures 1A to 1D The system 200 includes a paper tray 202 and an insert 204. Specifically, Figures 2A to 2E This demonstrates how to fold the cardboard box 202 from a storage configuration to an assembly configuration before inserting the insert 204 into the cardboard box 202. (See above for reference.) Figures 1A to 1D As discussed, the cardboard box 202 may include multiple side walls 213, top wall 214, and bottom wall 216 (in... Figure 2E (As shown in the diagram) and a rear flap 215 extending from the top wall 214. The carton 202 can be in a storage configuration before assembly. For example, the carton 202 can be in a storage configuration when it is first shipped or stored in a particular warehouse, and before it is assembled to contain one or more containers. Therefore, since the carton 202 can be shipped or stored in a storage configuration, multiple cartons 202 can be easily stacked for efficient shipping and warehousing.

[0099] During assembly, the carton 202 can be folded from a storage configuration to an assembly configuration. For example, the carton 202 may include one or more perforations, notches, or cuts along the edges of the sidewall 213, top wall 214, bottom wall 216, first flap 207a, second flap 207b, and / or rear flap 215, so that the carton 202 can be easily folded from a storage configuration to an assembly configuration. Figure 2A The paper box 202 is shown in its storage configuration before it is folded into its assembly configuration. Figures 2B to 2E The image shows the cardboard box 202 when it is folded from its storage configuration to its assembly configuration. (See image.) Figures 2B to 2E As shown, for example, when in an assembled configuration, the carton 202 can be configured as a rectangular carton including four side walls 213, a top wall 214, and a bottom wall 216. In the assembled configuration, at least the side walls 213 and the bottom wall 216 of the carton 202 can define a cavity 217 inside the carton 202. The cavity 217 can be configured to receive an insert 204 during assembly. As will be discussed in more detail below, the insert 204 can also be folded from a storage configuration to an assembled configuration before being placed inside the cavity 217 of the carton 202.

[0100] As discussed above, the cardboard box 202 may also include a first flap 207a extending from a first sidewall 213a of a plurality of sidewalls 213, and a second flap 207b extending from a second sidewall 213b opposite to and facing the first sidewall 213a. During assembly, the first flap 207a and the second flap 207b can be folded downwards (e.g., ...). Figure 2B (As shown). When folded downwards, the first flap 207a and the second flap 207b can define a first set of cavities 209, which can be configured to protect the container therein (such as container 208) from top load impacts. For example, when the first flap 207a and the second flap 207b fold downwards, as... Figure 2B As shown, the first set of cavities 209 can provide air damping, so that when a top load is placed on the top wall 214 of the carton 202, the space created within the first set of cavities 209 can be configured to dampen any container thereto and protect it from any vertical impact or damage. Furthermore, the rear flap 215 extending from the top wall 214 of the carton 202 can be folded (as shown). Figure 2B As shown), the rear flap 215 is inserted into the front sidewall among the multiple sidewalls 213 to close and secure the system 200 (as shown). Figure 1D (As shown). In some embodiments, the bottom wall 216 of the cardboard box 202 can be pre-configured to allow for automated assembly. For example, as shown... Figure 2E As shown, the bottom wall 216 of the paper box 202 can be pre-configured so that when the paper box 202 is folded from the storage configuration to the assembly configuration, the bottom wall 216 can automatically straighten into a flat surface to define the bottom surface of the paper box 202.

[0101] Figures 3A to 3D It shows that it is configured to be placed Figures 1A to 1D and Figures 2A to 2E The insert 204 inside the cardboard box 202. For example... Figure 3A As shown, insert 204 can be in a storage configuration before being assembled and placed inside cardboard box 202. For example, insert 204 can be in a storage configuration when it is first shipped or stored in a specific warehouse. Therefore, since insert 204 can be shipped or stored in a storage configuration, multiple inserts 204 can be easily stacked for efficient shipping and warehousing. During assembly, similar to cardboard box 202, insert 204 can be folded from a storage configuration to an assembly configuration. Figures 3B to 3D Insert 204 is shown, which folds from the storage configuration to the assembly configuration.

[0102] like Figures 3B to 3D As shown, once the insert 204 is folded into the assembled configuration, the insert may include at least two opposing sidewalls 219, a first layer 211, a second layer 212, and a third layer 218. For example, at least... Figure 3B and Figure 3D As shown, two sidewalls 219 can connect the first layer 211, the second layer 212, and the third layer 218. The first layer 211 can define the top surface of the insert 204 and can include a punched hole 206 configured to receive at least a portion of a container 208, such as a glass vial. Thus, the hole 206 can be configured to laterally stabilize the container 208 therein. As discussed above, the hole 206 can be sized to receive one or more of ISO 2R vials and 4 cc vials, ISO 6R vials, and ISO 10R and 10 cc vials. Furthermore, the hole 206 is spaced a distance from the edge of the first layer 211 such that when the container 208 is placed within the hole 206 of the insert 204, the container 208 will not contact any side of the insert 204 or any sidewall 213 of the carton 202. The second layer 212 can be positioned a first distance below the first layer 211 and can be configured to support the bottom surface of the container 208. The third layer 218 can define the bottom surface of the insert 204. For example, in Figure 3B and Figure 3D As can be seen, the second layer 212 is also positioned a second distance above the third layer 218, such that when the container 208 is placed inside the insert 204, the bottom surface of the container 208 is raised a second distance from the bottom surface of the insert 204 and the bottom wall 216 of the carton 202. Therefore, since the bottom surface of the container 208 is raised from the bottom wall 216 of the carton via the insert 204 and supported by the second layer 212, the system 200 can be configured to protect the container 208 from bottom load impacts. In some embodiments, the first distance and the second distance can be the same. That is, in some embodiments, the first layer 211 and the second layer 212 can be at the same distance from the second layer 212 and the third layer 218, respectively. In other embodiments, the first distance and the second distance can be different. For example, the distance between the second layer 212 and the third layer 217 can be greater than the distance between the second layer 212 and the first layer 211.

[0103] In some embodiments, such as Figures 3A to 3D As shown, the first layer 211 of the insert 204 may include a first set of flaps 210a extending from the opposite side of the first layer 211, and the second layer 212 may include a second set of flaps 210b extending from the opposite side of the second layer 212. The first set of flaps 210a and the second set of flaps 210b can be configured to fold downwards (e.g., Figure 3B and Figure 3CAs shown, two additional sidewalls define the insert 204. When folded downwards, the first set of flaps 210a and the second set of flaps 210b can be configured to provide additional stiffness to the insert 204, allowing the insert 204 to maintain its rectangular shape when folded into its assembled configuration. Furthermore, when folded downwards, the inner surface of the first set of flaps 210a of the first layer 211 can be configured to adjoin the outer surface of the second set of flaps 210b of the second layer 212. In some embodiments, the sidewalls 219, the first layer 211, the second layer 212, the third layer 218, the first set of flaps 210a, and the second set of flaps 210b can be integrally formed using fully recyclable sustainable materials, such as cardboard or other FSC-certified materials. Similar to cardboard box 202, insert 204 may include one or more perforations, notches or cuts along the edges of the first layer 211, the second layer 212, the third layer 218, the first set of flaps 210a and the second set of flaps 210b, so that insert 204 can be easily folded from storage configuration to assembly configuration.

[0104] As discussed above, insert 204 can be configured to be placed inside carton 202 during assembly (e.g., Figure 1A and Figure 1B (As shown). After the cardboard box 202 is folded into its assembled configuration and the insert 204 is also folded into its assembled configuration, the insert 204 can be configured to be placed inside the cavity 217 of the cardboard box 202 (in Figure 2D (As shown in the diagram). When placed inside the cavity 217 of the cardboard box 202, the inner surface of the first set of flaps 210a of the first layer 211 can be configured to adjoin the outer surface of the second set of flaps 210b of the second layer 212, and the outer surface of the first set of flaps 210a of the first layer 211 can be configured to adjoin the inner surfaces of the two opposing sidewalls 213 of the cardboard box 204. Return to Reference Figure 1A and Figure 1B Once the insert 204 is placed inside the carton 202 and the container 208 is placed within the hole 206 of the insert 204, the first flap 207a and the second flap 207b can be folded downwards, and the first set of cavities 209 can be configured to protect the container 208 from top load impacts. Furthermore, the rear flap 215 extending from the top wall 214 of the carton 202 can be inserted into the front sidewall of one of the multiple sidewalls 213 to close and secure the system 200 (e.g., Figure 1D(As shown). Therefore, when fully assembled and packaged, the hole 206 of the insert 204 can be configured to hold the container 208 in an upright position and protect the container 208 from subsequent impacts, the first set of cavities 209 defined by the first flap 207a and the second flap 207b can protect the container 208 from top load impacts, and the second layer 212 rising from the bottom surface of the insert 204 and the bottom wall 216 of the carton 202 can protect the container 208 from bottom load impacts.

[0105] In some embodiments, the aperture 206 in the insert 204 may be configured and sized to receive the neck of the container 208, such as the neck of a glass vial. Alternatively, the aperture 206 may be configured and sized to receive the body of the container 208, such as the body of a glass vial. In some embodiments, the size of the container 208 may be indicated by ISO 8362-1. For example, if the container 208 is a glass vial, ISO 8362-1 may indicate the standard capacity of the container 208, the standard height of the container 208, and / or the standard outer diameter of the body of the container 208. Therefore, in some embodiments, the aperture 206 may be sized to receive the container 208 based on the standard dimensions indicated by ISO 8362-1.

[0106] Figures 1A to 1D and Figures 2A to 2E A rectangular cardboard box 202 is shown, which includes four side walls 213, a top wall 214, and a bottom wall 216. Figures 3A to 3D A rectangular insert 204 is also shown, which includes four sidewalls and is configured to fit inside the cavity 217 of the cardboard box 202. However, the cardboard box 202 and / or the insert 204 are not limited to a rectangular shape. For example, the cardboard box 202 may include a cylindrical shape or any other geometry, and the insert 204 may be shaped to fit inside the cavity of the cardboard box 202.

[0107] Now for reference Figures 5A to 5F This illustration shows an exemplary system 300 for packaging multiple containers 208 according to various embodiments of this disclosure. System 300 may include a cardboard box 302 and an insert 304 configured to be placed inside the cardboard box 302. Insert 304 may include a plurality of openings 306 configured to receive the plurality of containers 308 therein. Figure 5AIn this system, insert 304 includes six holes 306, each configured to receive a corresponding container 308. However, insert 304 may include any number of holes 306, such as two, three, four, five, seven, eight, nine, ten, twelve, fifteen, twenty, twenty-five, or thirty holes. Holes 306 may be punched in insert 304, and holes 306 may be punched such that each hole is equidistant from each other. Furthermore, holes 306 may be punched such that holes 306 are spaced apart from the sidewalls of insert 304 and carton 302. By spaced apart from each other and also from all sides of insert 304 and carton 302, system 300 prevents the container 308 therein from contacting the sides of system 300 during packaging or transport, and thus protects the container 308 from lateral impacts. Holes 306 may also be configured to laterally stabilize each individual container 308 therein. Furthermore, the aperture 306 can be sized to accommodate containers 308 of various sizes. For example, the aperture 306 can be sized to accommodate one or more of ISO 2R vials and 4 cc vials, ISO 6R vials, and ISO 10R and 10 cc vials. In some embodiments, the aperture 306 may be all the same size and shape. In other embodiments, some apertures 306 may be of different sizes, allowing the insert 304 to accommodate containers 308 of various sizes.

[0108] In some embodiments, the cardboard box 302 and the insert 304 may be manufactured and formed separately. The cardboard box 302 and the insert 304 may be manufactured using fully recyclable sustainable materials, such as cardboard or other FSC-certified materials. In other embodiments, the cardboard box 302 and the insert 304 may be manufactured and formed integrally. In some embodiments, such as Figure 6B As shown, the cardboard box 302 may include multiple side walls 313, a top wall 314, and a bottom wall 316 (similar to...). Figure 2E The bottom wall 216) and the rear flap 315 extending from the top wall 314. (Return to reference) Figures 5A to 5E The cardboard box 302 may also include a first flap 307a extending from a first sidewall 313a of a plurality of sidewalls 313, and a second flap 307b extending from a second sidewall 313b opposite to and facing the first sidewall 313a. The first flap 307a and the second flap 307b may define a first set of cavities 309, such as Figure 5D and Figure 5E As shown. In some embodiments, the first set of cavities 309 may include rectangular air cavities. In other embodiments, the first set of cavities 309 may include triangular, circular, or elliptical air cavities. The first set of cavities 309 may be configured to protect the container 308 therein from top load impacts. For example, when the flaps 307a, 307b are folded downwards, as... Figure 5E As shown, the first set of cavities 309 can provide air damping, such that when a top load is placed on top of the cardboard box 302, the space created within the first set of cavities 309 can be configured to dampen the container 308 therein and protect the container 308 from any vertical impact or damage. In some embodiments, the side wall 313, top wall 314, bottom wall 316, rear flap 315, first flap 307a, and second flap 307b can be integrally formed.

[0109] Figures 6A to 6C , Figures 7A to 7D and Figure 8 Showed in more detail Figures 5A to 5F The system 300 includes a paper tray 302 and an insert 304. Specifically, Figures 6A to 6C This demonstrates how to fold the cardboard box 302 from a storage configuration to an assembly configuration before inserting the insert 304 into the cardboard box 302. (As shown) Figures 6A to 6C As shown, the cardboard box 302 may include multiple side walls 313, a top wall 314, a bottom wall 316, and a rear flap 316 extending from the top wall 314. Before assembly, the cardboard box 302 can be in a storage configuration, such as... Figure 6A As shown. For example, when the cardboard box 302 is first shipped or stored in a particular warehouse, and before the cardboard box 302 is assembled to contain one or more containers 308, the cardboard box 302 may be in a storage configuration. Therefore, since the cardboard box 302 can be shipped or stored in a storage configuration, multiple cardboard boxes 302 can be easily stacked for efficient shipping and warehousing.

[0110] During assembly, the carton 302 can be folded from a storage configuration to an assembly configuration. For example, the carton 302 may include one or more perforations, notches, or cuts along the edges of the sidewall 313, top wall 314, bottom wall 316, first flap 307a, second flap 307b, and / or rear flap 315, so that the carton 302 can be easily folded from a storage configuration to an assembly configuration. Figure 6A The image shows the cardboard box 302 in its storage configuration before it is folded into its assembly configuration. Figure 6B The image shows cardboard box 302 folded from its storage configuration to its assembly configuration. (See image.) Figure 6B As shown, when in the assembled configuration, the cardboard box 302 can form a rectangular cardboard box including four side walls 313, a top wall 314, and a bottom wall 316. In the assembled configuration, at least the side walls 313 and the bottom wall 316 of the cardboard box 302 can define a cavity 317 inside the cardboard box 302. The cavity 317 can be configured to receive an insert 304 during assembly. As will be discussed in more detail below, the insert 304 can also be folded from the storage configuration to the assembled configuration before being placed inside the cavity 317 of the cardboard box 302.

[0111] like Figures 5A to 5F and Figures 6A to 6C As shown, the cardboard box 302 may also include a first flap 307a extending from a first sidewall 313a of a plurality of sidewalls 313, and a second flap 307b extending from a second sidewall 313b. During assembly, the first flap 307a and the second flap 307b can be folded downwards (e.g., Figure 5D , Figure 5E and Figure 6B (As shown). When folded downwards, the first flap 307a and the second flap 307b can define the first set of cavities 309 (in... Figure 5D and Figure 5E As shown in the diagram, the first set of cavities can be configured to protect the container 308 therein from top load impacts. For example, when the first flap 307a and the second flap 307b fold downwards, as... Figure 5E As shown, the first set of cavities 309 can provide air damping, such that when a top load is placed on the top wall 314 of the carton 302, the space created within the first set of cavities 309 can be configured to dampen the containers 308 therein and protect them from any vertical impact or damage. Furthermore, the rear flap 315 extending from the top wall 314 of the carton 302 (in...) Figure 5C and Figure 6B (As shown in the image) can be folded downwards so that the rear flap 315 is inserted into the front sidewall among the multiple sidewalls 313 to close and secure the system 300 (as shown in the image). Figure 5F and Figure 6C (As shown). In some embodiments, the bottom wall 316 of the paper box 302 can be pre-configured to allow automatic assembly. For example, similar to the bottom wall 216 shown in FIG. 3E, the bottom wall 316 of the paper box 302 can be pre-configured such that when the paper box 302 is folded from the storage configuration to the assembly configuration, the bottom wall 316 can automatically straighten into a flat surface to define the bottom surface of the paper box 302.

[0112] Figures 7A to 7D and Figure 8 It shows that it is configured to be placed Figures 5A to 5F and Figures 6A to 6C The insert 304 inside the cardboard box 302. For example... Figure 7A As shown, insert 304 can be in a storage configuration before being assembled and placed inside cardboard box 302. For example, similar to cardboard box 302, insert 304 can be in a storage configuration when it is first shipped or stored in a specific warehouse. Therefore, since insert 304 can be shipped or stored in a storage configuration, multiple inserts 304 can be easily stacked for efficient shipping and warehousing. During assembly, similar to cardboard box 302, insert 304 can be folded from a storage configuration to an assembly configuration. Figures 7B to 7D and Figure 8 Insert 304 is shown, which folds from the storage configuration to the assembly configuration.

[0113] like Figures 7B to 7D and Figure 8 As shown, once the insert 304 is folded into the assembled configuration, the insert may include at least two opposing sidewalls 319, a first layer 311, a second layer 312, a third layer 318, and a fourth layer 320. For example, at least... Figure 7B , Figure 7C and Figure 8 As shown, two sidewalls 319 can connect the first layer 311, the second layer 312, the third layer 318, and the fourth layer 320. The first layer 311 can define the top surface of the insert 304 and can include punch holes 306 configured to receive at least a portion of a plurality of containers 308, such as glass vials. The holes 306 can be sized to receive one or more of ISO 2R vials and 4 cc vials, ISO 6R vials, and ISO 10R and 10 cc vials. Furthermore, the holes 306 can be spaced apart from each other and away from the edge of the first layer 311, such that when the containers 308 are placed in the corresponding holes 306 of the insert 304, the containers 308 will not contact each other, nor any side of the insert 304, nor any sidewall 313 of the carton 302. The second layer 312 may be positioned a first distance below the first layer 311 and may further include punched holes 306 configured to receive at least a portion of a plurality of containers 308, such as glass vials. The holes 306 in the second layer 312 may be vertically aligned with the holes 306 in the first layer 311 such that when a container 308 is placed in the corresponding hole 306, each container 308 will be fitted through the corresponding hole 306 in both the first layer 311 and the second layer 312. The third layer 318 may be positioned a second distance below the second layer 312 and may be configured to support the bottom surface of each container 308. The fourth layer 320 may be positioned a third distance below the third layer 318 and may define the bottom surface of the insert 304.

[0114] like Figure 8As shown, the third layer 318 is also positioned a third distance above the fourth layer 320, such that when the container 308 is placed inside the insert 304, the bottom surface of the container 308 is raised a third distance from the bottom surface of the insert 304 and the bottom wall 316 of the carton 302. Therefore, since the bottom surface of the container 308 is raised from the bottom wall 316 of the carton 302 via the insert 304 and supported by the third layer 318, the system 300 can be configured to protect the container 308 from bottom load impacts. In some embodiments, the first, second, and third distances may be the same, such that the first layer 311, second layer 312, third layer 318, and fourth layer 320 are all equidistant from each other. In other embodiments, the first distance may be different from at least one of the second or third distances. For example, the distance between the third layer 318 and the fourth layer 320 may be greater than the distance between the third layer 318 and the second layer 312.

[0115] In some embodiments, the insert 304 may further include a vertical rib support 321 extending between the third layer 318 and the fourth layer 320, such as Figure 8 As shown. The vertical rib support 321 can be integrally formed with the insert 304. The vertical rib support 321 can be configured to maintain a third distance between the third layer 318 and the fourth layer 320, such that the container 308 is always raised from the bottom wall 316 of the carton 302 and supported by the third layer 318 of the insert 304. Therefore, the vertical rib support 321 can ensure that the container 308 is protected from bottom load impacts. In addition, the vertical rib support 321 can be configured to help the third layer 318 support the weight of the container 308.

[0116] Return to reference Figure 7B and Figure 7C The first layer 311 of the insert 304 may include a first set of flaps 310a extending from the opposite side of the first layer 311, and the second layer 312 may include a second set of flaps 310b extending from the opposite side of the second layer 312. The first set of flaps 310a and the second set of flaps 310b may be configured to fold downwards (e.g., Figure 7C and Figure 7DAs shown, two additional sidewalls define the insert 304. When folded downwards, the first set of flaps 310a and the second set of flaps 310b can be configured to provide additional stiffness to the insert 304, allowing the insert 304 to maintain its rectangular shape when folded into its assembled configuration. Furthermore, when folded downwards, the inner surface of the first set of flaps 310a of the first layer 311 can be configured to adjoin the outer surface of the second set of flaps 310b of the second layer 312. In some embodiments, the sidewalls 319, the first layer 311, the second layer 312, the third layer 318, the fourth layer 320, the first set of flaps 310a, and the second set of flaps 310b can be integrally formed using fully recyclable sustainable materials, such as cardboard or other FSC-certified materials.

[0117] In some embodiments, the insert 304 may be configured to be placed inside the carton 302 during assembly (e.g., Figures 5C to 5E (As shown). After the cardboard box 302 is folded into its assembled configuration and the insert 304 is also folded into its assembled configuration, the insert 304 can be configured to be placed inside the cavity 317 of the cardboard box 302 (in Figure 6B (As shown in the diagram). When placed inside the cavity 317 of the cardboard box 302, the inner surface of the first set of flaps 310a of the first layer 311 can be configured to adjoin the outer surface of the second set of flaps 310b of the second layer 312, and the outer surface of the first set of flaps 310a of the first layer 311 can be configured to adjoin the inner surfaces of the two opposing sidewalls 313 of the cardboard box 304. Once the insert 304 is placed inside the cardboard box 302 and the container 308 is placed in the corresponding hole 306 of the insert 304, the first flap 307a and the second flap 307b can be folded downwards (as shown in the diagram). Figure 5D and Figure 5E (As shown), and the first set of cavities 309 can be configured to protect the container 308 therein from top load impacts. Furthermore, a rear flap 315 extending from the top wall 314 of the carton 302 can be inserted into the front sidewall of one of the multiple sidewalls 313 to close and secure the system 300 (as shown). Figure 5F(As shown). Therefore, when fully assembled and packaged, the holes 306 in the first layer 311 and the second layer 312 of the insert 304 can be configured to hold the container 308 in an upright position and protect it from subsequent impacts. The first set of cavities 309 defined by the first flap 307a and the second flap 307b can protect the container 308 from top load impacts, and the third layer 318, rising from the bottom surface of the insert 304 and the bottom wall 316 of the carton 302, can protect the container 308 from bottom load impacts. Similar to the carton 302, the insert 304 may include one or more perforations, notches, or cuts along the edges of the first layer 311, the second layer 312, the third layer 318, the fourth layer 320, the first set of flaps 310a, and the second set of flaps 310b, so that the insert 304 can be easily folded from a storage configuration to an assembled configuration.

[0118] In some embodiments, the hole 306 in the insert 304 may be configured and sized to receive the neck of each respective container 308, such as the neck of a glass vial. Alternatively, the hole 306 may be configured and sized to receive the body of each respective container 308, such as the body of a glass vial. For example, Figure 8 A hole 306 in the first layer 311 of the insert 304 is shown, which receives a first portion of the body of the container 308; and a hole 306 in the second layer 312 of the insert 304, which receives a second portion of the body of the container 308 below the first portion. However, in other embodiments, the hole 306 in the first layer 311 of the insert 304 may be configured to receive the neck of the container 308, while the hole 306 in the second layer 312 of the insert 304 may be configured to receive the body of the container 308. The holes 306 in the first layer 311 and the second layer 312 of the insert 304 may be configured to secure the container 308 in its upright position and protect the container 308 from subsequent impacts or displacement. Although Figures 5A to 5F , Figures 6A to 6C , Figures 7A to 7D and Figure 8 The system 300 includes six holes 306 in each of the first layer 311 and the second layer 312 of the insert 304, such that the insert 304 can accommodate up to six containers 308, but is not limited to six holes 306. For example, as will be discussed in more detail below, the insert can include any number of punched holes, such as two, three, four, five, seven, eight, nine, ten, twelve, fifteen, twenty, twenty-five, or thirty holes, such that the system can accommodate various numbers of containers 308.

[0119] In some embodiments, the size of container 308 may be indicated by ISO 8362-1. For example, if container 308 is a glass vial, ISO 8362-1 may indicate the standard capacity of container 308, the standard height of container 308, and / or the standard outer diameter of the body of container 308. Therefore, in some embodiments, aperture 306 may be sized to accommodate container 308 based on the standard dimensions indicated by ISO 8362-1. Additionally or alternatively, container 308 packaged within system 300 may include glass vials, such as ISO 2R vials and 4 cc vials, ISO 6R vials, and / or ISO 10R and 10 cc vials. In some embodiments, aperture 306 in each insert 304 may be sized and configured to accommodate only one size of container 308, such as one of ISO 2R vials and 4 cc vials, ISO 6R vials, and ISO 10R and 10 cc vials. In other embodiments, the opening 306 in each insert 304 can be sized and configured to accommodate containers 308 of various sizes, such as two or more of ISO 2R and 4 cc vials, ISO 6R vials, and ISO 10R and 10 cc vials. In yet another embodiment, the insert 304 can be manufactured separately from the carton 302, and the inserts can be interchangeably placed inside the carton 302. Thus, one insert 304 with an opening 306 sized to accommodate an ISO 6R vial can be placed inside the carton 302, and can also be replaced with a different insert 304 with an opening 306 sized to accommodate an ISO 10R vial. Thus, a carton 302 can be interchangeably used to package containers 308 of various sizes, depending on the insert 304 placed therein.

[0120] Figures 5A to 5F and Figures 6A to 6C A rectangular cardboard box 302 is shown, which includes four side walls 313, a top wall 314, and a bottom wall 316. Figures 7A to 7D A rectangular insert 304 is also shown, which includes four sidewalls and is configured to fit inside the cavity 317 of the cardboard box 302. However, the cardboard box 302 and / or the insert 304 are not limited to a rectangular shape. For example, the cardboard box 302 may include a cylindrical shape or any other geometry, and the insert 304 may be shaped to fit inside the cavity of the cardboard box 302.

[0121] Figure 4A A plan view of the punched portion of the cardboard box 302 according to various embodiments of this disclosure is shown, and Figure 4BA plan view of the punched portion of insert 304 is shown. The carton 302 and insert 304 can be made from a single material. For example, the carton 302 and insert 304 can be made of cardboard, corrugated cardboard, cardboard, or similar materials. In some embodiments, the carton 302 and insert 304 can be made from a combination of natural and synthetic materials. In other embodiments, the carton 302 and / or insert 304 can be made from multiple parts glued or otherwise fixed together.

[0122] As in Figure 4A As can be seen, the cardboard box 302 includes multiple fold lines 330, which divide the cardboard box 302 into multiple walls and flaps. Figure 4A A paper box 302 is shown in its storage configuration, wherein the paper box 302 is substantially flat. The paper box 302 can be folded into an assembly configuration. For example, when each of the plurality of fold lines 330 is folded, the paper box 302 can be folded into an assembly configuration to form a box-shaped paper box, such as... Figures 5B to 5F , Figure 6B and Figure 6C As shown.

[0123] like Figure 4A As shown, flaps 316a to 316d can be fixed together to form the bottom wall 316 of the cardboard box 302. The cardboard box 302 can be folded along each of the fold lines 330, such as... Figure 4A As shown, flap 326 can be fixed to the inner surface of the second sidewall 313b by glue, adhesive, or any other method of fixing the two surfaces together to form a box-shaped cardboard box 302. Furthermore, flap 325a can be fixed to the inner surface of flap 307a, and flap 325b can be fixed to the inner surface of flap 307b by glue, adhesive, or any other method of fixing the two surfaces together to form a first flap 307a and a second flap 307b defining the first set of cavities 309, for example, as... Figure 5D and Figure 5E As shown.

[0124] Similarly, the insert 304 includes a plurality of fold lines 331 that divide the insert 304 into a plurality of walls and flaps. Figure 4B The insert 304 is shown in its storage configuration, wherein the insert 304 is substantially flat. The insert 304 can be folded into an assembly configuration. For example, when each of the plurality of fold lines 331 is folded, the insert 304 can be folded into an assembly configuration to form an assembled insert 304, such as... Figure 8 As shown. Insert 304 can be folded along each of the fold lines 331, flap 327 can be secured to the inner surface of one of the sidewalls 319, and flap 328 can be secured to the inner surface of the other of the sidewalls 319 (e.g., Figure 8 (As shown) to form an assembled insert 304. The flaps 327, 328 can be fixed to the inner surface of the opposite sidewall 319 by glue, adhesive or other methods of fixing the two surfaces together to form the assembled insert 304.

[0125] Now for reference Figures 10A to 10D and Figure 11 This illustration shows another exemplary system 400 for packaging multiple containers 408 according to various embodiments of this disclosure. Similar to system 300 discussed above, system 400 may include a cardboard box 402 and an insert 404 configured to be placed inside the cardboard box 402. It should be understood that the components of system 400 are similar in detail to those of system 300 discussed above. For the sake of brevity, the components of system 400 will not be discussed in substantial detail.

[0126] like Figure 10A and Figure 10B As shown, insert 404 may include a plurality of holes 406 configured to receive a plurality of containers 408 therein. Insert 404 may include twelve holes 406, each hole configured to receive a corresponding container 408. In other embodiments, insert 404 may include any number of holes 406, such as fifteen, sixteen, twenty, twenty-five, or thirty holes. Similar to the holes 306 of system 300, the holes 406 of system 400 are punched and spaced apart from each other and away from the sidewalls of insert 404 and carton 402 to protect the containers 308 therein from lateral impacts. Holes 406 may also be configured to laterally stabilize each individual container 408 therein. Furthermore, holes 406 may be sized to accommodate containers 408 of various sizes. For example, holes 406 may be sized to accommodate one or more of ISO 2R vials and 4 cc vials, ISO 6R vials, and ISO 10R and 10 cc vials.

[0127] In some embodiments, the cardboard box 402 and insert 404 may be manufactured using fully recyclable sustainable materials, such as cardboard or other FSC-certified materials. Figures 10A to 10DAs shown, the cardboard box 402 may include a rectangular cardboard box having a plurality of side walls 413, a top wall 414, a bottom wall 416 (similar to the bottom wall 216 of system 200 and the bottom wall 316 of system 300), and a rear flap 415 extending from the top wall 414. The cardboard box 402 may also include a first flap 407a extending from a first side wall 413a of the plurality of side walls 414, and a second flap 407b extending from a second side wall 413b opposite to and facing the first side wall 413a. The first flap 407a and the second flap 407b may define a first set of cavities 409. In some embodiments, the first set of cavities 409 may include a rectangular air cavity, and when folded downwards (e.g., ...), Figure 10C As shown), the first set of cavities 409 can be configured to protect the container 408 therein from top load impacts. The rear flap 415 can also be folded down, such that the rear flap 415 is inserted into the front sidewall among the multiple sidewalls 413 to close and secure the system 400 (as shown). Figure 10D (As shown). In some embodiments, the sidewall 413, top wall 414, bottom wall 416, rear flap 415, first flap 407a, and second flap 407b may be integrally formed. In some embodiments, similar to the bottom wall 216 of system 200 and the bottom wall 316 of system 300, the bottom wall 416 may be pre-configured such that when the carton 402 is folded from a storage configuration to an assembly configuration, the bottom wall 416 may automatically straighten into a flat surface to define the bottom surface of the carton 402.

[0128] Despite Figures 10A to 10D Although not shown, system 400 can be folded from a storage configuration to an assembly configuration, similar to systems 200 and 300 discussed above. Therefore, before assembly, both the cardboard box 402 and the insert 404 of system 400 can be transported and stored in the storage configuration. During assembly, the cardboard box 402 and the insert 404 can be folded from the storage configuration to the assembly configuration. Figures 10A to 10D The system 400 is shown when both the cardboard box 402 and the insert 404 are folded into the assembled configuration. (See diagram below.) Figure 10A As shown, in the assembly configuration, the cardboard box 402 may include a cavity 417 defined by at least side walls 413 and a bottom wall 416. The cavity 417 may be configured to receive an insert 404, such as... Figure 10B As shown.

[0129] Figure 11 A side view is shown of the insert 404 configured to be placed inside the cardboard box 402. As discussed above, the insert 404 can be folded from a storage configuration to an assembled configuration during assembly. Figure 11As shown, once the insert 404 is folded into its assembled configuration, the insert may include at least two opposing sidewalls 419, a first layer 411, a second layer 412, a third layer 418, and a fourth layer 420. The two sidewalls 419 may connect the first layer 411, the second layer 412, the third layer 418, and the fourth layer 420. The first layer 411 may define the top surface of the insert 404 and may include punch holes 406 configured to receive at least a portion of a plurality of containers 408, such as glass vials. The second layer 412 may be positioned a first distance below the first layer 411 and may also include punch holes 406 configured to receive at least a portion of a plurality of containers 408, such as glass vials. The holes 406 in the second layer 412 can be vertically aligned with the holes 406 in the first layer 411, such that when a container 408 is placed in the corresponding hole 406, each container 408 will be assembled through the corresponding hole 406 in both the first layer 411 and the second layer 412. The third layer 418 can be positioned a second distance below the second layer 412 and can be configured to support the bottom surface of each container 408. The fourth layer 420 can be positioned a third distance below the third layer 418 and can define the bottom surface of the insert 404. The third layer 418 can be positioned a third distance above the fourth layer 420 to protect the containers 408 therein from bottom load impacts. In some embodiments, the first, second, and third distances can be the same, such that the first layer 411, second layer 412, third layer 418, and fourth layer 420 are all equidistant from each other. In other embodiments, the first distance can be different from at least one of the second or third distances. For example, the distance between the third layer 418 and the fourth layer 420 can be greater than the distance between the third layer 418 and the second layer 412.

[0130] like Figure 11As shown, the insert 404 may further include a vertical rib support 421 extending between the third layer 418 and the fourth layer 420. The vertical rib support 421 may be integrally formed with the insert 404 and may be configured to maintain a third distance between the third layer 418 and the fourth layer 420. The vertical rib support 421 may ensure that the container 408 is protected from bottom load impacts and may be configured to help the third layer 418 support the weight of the container 408. In some embodiments, the first layer 411 of the insert 404 may include a first set of flaps 410a extending from the opposite side of the first layer 411, and the second layer 412 may include a second set of flaps 410b extending from the opposite side of the second layer 412. The first set of flaps 410a and the second set of flaps 410b may be configured to fold downward to define two additional sidewalls of the insert 404. When folded downwards, the first set of flaps 410a and the second set of flaps 410b can be configured to provide additional stiffness to the insert 404, allowing the insert 404 to maintain its rectangular shape when folded into its assembled configuration. Furthermore, when folded downwards, the inner surface of the first set of flaps 410a of the first layer 411 can be configured to adjoin the outer surface of the second set of flaps 410b of the second layer 412. In some embodiments, the sidewall 419, the first layer 411, the second layer 412, the third layer 418, the fourth layer 420, the first set of flaps 410a, and the second set of flaps 410b can be integrally formed using fully recyclable sustainable materials, such as cardboard or other FSC-certified materials.

[0131] Figure 11 A hole 406 in the first layer 411 of the insert 404 is shown, which receives a first portion of the body of the container 408; and a hole 406 in the second layer 412 of the insert 404, which receives a second portion of the body of the container 408 below the first portion. However, in other embodiments, the hole 406 in the first layer 411 of the insert 404 may be configured to receive the neck of the container 408, while the hole 406 in the second layer 412 of the insert 404 may be configured to receive the body of the container 408. The hole 406 may be configured to hold the container 408 in its upright position and protect the container 408 from subsequent impacts or displacement.

[0132] In some embodiments, the size of container 408 may be indicated by ISO 8362-1. For example, when container 408 is a glass vial, ISO 8362-1 may indicate the standard capacity of container 408, the standard height of container 408, and / or the standard outer diameter of the body of container 408. Container 408 packaged inside system 400 may include glass vials, such as ISO 2R vials and 4 cc vials, ISO 6R vials, and / or ISO 10R and 10 cc vials. In some embodiments, the hole 406 in each insert 404 may be sized and configured to accommodate only one size of container 408, such as one of ISO 2R vials and 4 cc vials, ISO 6R vials, and ISO 10R and 10 cc vials. In other embodiments, the opening 406 can be sized and configured to accommodate containers 408 of various sizes, such as two or more of ISO 2R and 4 cc vials, ISO 6R vials, and ISO 10R and 10cc vials. In yet another embodiment, the insert 404 can be manufactured separately from the carton 402, and the insert can be interchangeably placed inside the carton 402. Thus, one insert 404 having an opening 406 sized to accommodate ISO 6R vials can be placed inside the carton 402, and can also be replaced with different inserts 404 having an opening 406 sized to accommodate ISO 10R vials. Thus, a carton 402 can be interchangeably used to package containers 408 of various sizes, depending on the insert 404 placed therein.

[0133] Figure 9A A plan view of the punched portion of the cardboard box 402 according to various embodiments of this disclosure is shown, and Figure 9B A plan view of the punched portion of insert 404 is shown. The carton 402 and insert 404 can be made from a single material. For example, the carton 402 and insert 404 can be made of cardboard, hardboard, cardboard, or similar materials. In some embodiments, the carton 402 and insert 404 can be made from a combination of natural and synthetic materials. In other embodiments, the carton 402 and / or insert 404 can be made from multiple pieces glued or otherwise fixed together.

[0134] As in Figure 9A As can be seen, the cardboard box 402 includes multiple fold lines 430, which divide the cardboard box 402 into multiple walls and flaps. Figure 9A A paper box 402 is shown in its storage configuration, wherein the paper box 402 is substantially flat. The paper box 402 can be folded into an assembly configuration. For example, when each of the plurality of fold lines 430 is folded, the paper box 402 can be folded into an assembly configuration to form a box-shaped paper box, such as... Figures 10A to 10D As shown.

[0135] like Figure 9A As shown, flaps 416a to 416d can be secured together to form the bottom wall 416 of the cardboard box 402. The cardboard box 402 can be folded along each of the fold lines 430, such as... Figure 9A As shown, flap 426 can be fixed to the inner surface of the second sidewall 413b by glue, adhesive, or any other method of fixing the two surfaces together to form a box-shaped cardboard box 402. Furthermore, flap 425a can be fixed to the inner surface of flap 407a, and flap 425b can be fixed to the inner surface of flap 407b by glue, adhesive, or any other method of fixing the two surfaces together to form a first flap 407a and a second flap 407b defining the first set of cavities 409, for example, as... Figure 10C As shown.

[0136] Similarly, the insert 404 includes a plurality of fold lines 431 that divide the insert 404 into a plurality of walls and flaps. Figure 9B The insert 404 is shown in its storage configuration, wherein the insert 404 is substantially flat. The insert 404 can be folded into an assembly configuration. For example, when each of the plurality of fold lines 431 is folded, the insert 404 can be folded into an assembly configuration to form an assembled insert 404, such as... Figure 11 As shown. Insert 404 can be folded along each of the fold lines 431, flap 427 can be secured to the inner surface of one of the sidewalls 419, and flap 428 can be secured to the inner surface of the other of the sidewalls 419 (e.g., Figure 11 (As shown) to form an assembled insert 404. The flaps 427, 428 may be attached to the inner surface of the opposite sidewall 419 by glue, adhesive or other methods of fixing the two surfaces together to form the assembled insert 404.

[0137] Figure 12A This is a plan view of a die-cut portion of a cardboard box 502 from another exemplary system for packaging containers according to various embodiments of this disclosure. The cardboard box 502 may be made from a single material. For example, the cardboard box 502 may be made from cardboard, corrugated cardboard, cardboard, or similar materials. In some embodiments, the cardboard box 502 may be made from a combination of natural and synthetic materials. In other embodiments, the cardboard box 502 may be made from several pieces glued together or otherwise secured together. The cardboard box 502 includes a plurality of fold lines 530 that divide the cardboard box 502 into a plurality of walls and flaps. Figure 12A A paper box 502 in a storage configuration is shown, wherein the paper box 502 is substantially or completely flat. The paper box 502 can be stored in a substantially flat storage configuration (such as...). Figure 12A(As shown) Stand up or fold into an assembled configuration (such as) Figure 13A (As shown). For example, when each of the multiple fold lines 530 has been folded, the cardboard box 502 can be erected into an assembly configuration to form a box-shaped cardboard box, such as... Figure 13A As shown.

[0138] refer to Figure 12A , Figure 13A and Figure 13B The cardboard box 502 includes a bottom box body 503 (in Figure 13A As shown in the diagram, the bottom box has multiple flaps 516a to 516d (in... Figure 12A The first bottom wall 516 (shown in) is made of Figure 13B (As shown in the diagram), a first sidewall 513b, a second sidewall 513d, a first rear wall 513a, and a first front wall 513c. Flaps 516a to 516d can be secured to each other via interlocking slots, other adhesives, or other known methods of assembling boxes and cartons to form a first bottom wall 516 when assembling the cartons 502. The first rear wall 513a includes a flap 526 that can, for example, be glued to the inner surface of the second sidewall 513d to form a bottom box body 503. In some embodiments, the first rear wall 513a can be secured to the second sidewall 513d via interlocking slots, other adhesives, or other known methods of assembling boxes and cartons. Thus, the first sidewall 513b, the second sidewall 513d, the first rear wall 513a, the first front wall 513c, and the first bottom wall 516 are all secured together to form the bottom box body 503.

[0139] Furthermore, the carton 502 includes a lid 514 hinged to or coupled to the first rear wall 513a. In some embodiments, the lid 514 is a top cover movable between an open position and a closed position and includes a flap 515. When the carton 502 is assembled, the lid 514 can be moved from an open position, accessible to the interior of the bottom box 503, to a closed position, inaccessible to the interior of the bottom box 503. Additionally, the flap 515 of the lid 514 can be folded and tucked behind the first front wall 513c to secure the carton 502 in the closed position and prevent accidental opening of the carton 502.

[0140] Furthermore, the cardboard box 502 may include a first flap 507a and a second flap 507b extending from a first sidewall 513b and a second sidewall 513d of the bottom box body 503, respectively. For example... Figure 12A and Figure 13AAs shown, the second sidewall 513d is positioned opposite and facing the first sidewall 513b. In other words, the first sidewall 513b and the second sidewall 513d are opposing walls of the bottom box 503. The first flap 507a may include a tab 525a at one end, and the second flap 507b may also include a tab 525b at one end. When the box 502 is folded into an assembled configuration along a plurality of fold lines 530, the tabs 525a and 525b may be fixed to the inner surfaces of the first sidewall 513b and the second sidewall 513d, respectively, such that the first flap 507a and the second flap 507b define a set of cavities 509 (in Figure 13A (As shown in the figure). In some embodiments, tabs 525a and 525b may be glued to the inner surfaces of the first sidewall 513b and the second sidewall 513d, respectively. In other embodiments, tabs 525a and 525b may be secured to the inner surfaces of the first sidewall 513b and the second sidewall 513d, respectively, via interlocking slits, other adhesives, or other known methods of assembling boxes and cartons. When the carton 502 is assembled, the set of cavities 509 defined by the first flap 507a and the second flap 507b may include rectangular air cavities. In some embodiments, the set of cavities 509 may be configured to protect one or more containers disposed within the bottom box body 503 from top load impacts.

[0141] In some embodiments, the bottom housing 503 of the cardboard box 502 includes a release tab 562. For example... Figure 12A As shown, for example, the first front wall 513c includes a perforated line 560 surrounding the release tab 562, the perforated line being adjacent to the bottom edge 564 of the first front wall 513c. The release tab 562 is surrounded by the perforated line 560 and the bottom edge 564. The release tab 562 includes a first kiss-shaped cut 566. In some embodiments, an adhesive (such as an adhesive label) may be positioned on at least a portion of the release tab 562. The first kiss-shaped cut 566 may improve the fixation between the release tab 562 and the adhesive. When sufficient force is applied to the release tab 562, the perforated line 560 allows the release tab 562 to be detached from the first front wall 513c. Figure 12A As shown, the release tab 562 is a partially rectangular shape with rounded edges; however, the release tab 562 can be any shape of various shapes (including semicircles, triangles, quadrilaterals, pentagons, etc.).

[0142] In addition or alternatively, such as Figure 12AAs shown, the cover 514 of the bottom housing 503 may also include a perforated line 580 surrounding the release tab 582, the perforated line being adjacent to the edge 584 between the cover 514 and the flap 515 of the cover. The release tab 582 is surrounded by the perforated line 580 and the edge 584. When sufficient force is applied to the release tab 582, the perforated line 580 allows the release tab 582 to be removed from the cover 514. Figure 12A As shown, the release tab 582 is a partially rectangular shape with rounded edges; however, the release tab 582 can be any shape of various shapes (including semicircles, triangles, quadrilaterals, pentagons, etc.).

[0143] In some embodiments, when the carton 502 is folded into an assembled configuration and the cover 540 is placed on the bottom box 503, the release tab 582 on the cover 514 can be aligned with the release tab 562 on the first front wall 513c of the bottom box 503, such that the release tabs 582 and 562 are positioned perpendicular to each other. Edges 584 and 564 that partially define the release tabs 582 and 562, respectively, can be aligned with each other and positioned adjacent to each other. In some embodiments, the release tabs 582 and / or 562 can be push tabs that detach the release tabs from the cover 514 and / or the first front wall 513c of the bottom box 503. In some embodiments, adhesive (such as an adhesive label) can be positioned on the release tabs 582 and / or 562. Therefore, the release tabs 582 and / or 562 can include kiss-shaped cuts 568, 566 to improve the retention between the release tabs and the adhesive.

[0144] Release tabs 582 and 562 may be partially externally connected by perforated lines 580 and 560, respectively. Perforated lines 580 and 560 may each consist of a series of cuts. Kiss-shaped cuts 568 and 566 may each be portions passing through release tabs 582 and 562, respectively, which improve adhesion between release tabs 582, 562 and the tamper-evident seal by increasing the surface area to which the tamper-evident seal can adhere. The tamper-evident seal may be, for example, an adhesive seal, such as an adhesive or sealing label for sealing carton 502. For example, adhesive may be applied to the kiss-shaped cut 568 on the lid 514 and the kiss-shaped cut 566 on the first front wall 513c of the bottom carton 503 to seal carton 502 in a closed position. The adhesive can act as a tamper-evident seal. That is, any attempt to peel the adhesive off carton 502 will result in visible damage to carton 502 and / or the adhesive. For example, when the lid 514 is in the closed position and the cardboard box 502 is sealed, release tabs 582 and 562 can be secured to the lid 514 and the first front wall 513c, respectively. When a person attempts to peel the adhesive off the cardboard box 502 and the lid 514 is in the open position, one or both of the release tabs 582 and 562 can be separated from the lid 514 and / or the first front wall 513c along the corresponding perforation lines 580, 560. In some embodiments, when a person attempts to peel the adhesive off the cardboard box 502, one of the release tabs 582 and 562 can be separated from one of the lid 514 and the first front wall 513c along the corresponding perforation lines 580, 560, and can be secured to the other of the lid 514 and the first front wall 513c via adhesive.

[0145] Figure 12B This is a plan view of a punched portion of an insert 504 configured to be disposed within the bottom body 503 of a cardboard box 502, according to various embodiments of this disclosure. The insert 504 may be made of a single material. For example, the insert 504 may be made of cardboard, corrugated cardboard, cardboard, or similar materials. In some embodiments, the insert 504 may be made of a combination of natural and synthetic materials. In other embodiments, the insert 504 may be made of several pieces glued together or otherwise fixed together. Figure 12B As shown, the insert 504 includes a plurality of fold lines 531 that divide the insert 504 into a plurality of walls 510a to 510g. Figure 12B The insert 504 is shown in a flat configuration. Similar to the cardboard box 502, the insert 504 is located in a substantially flat storage configuration (in...). Figure 12B (As shown in the image) Stand up and assemble into a configuration (in) Figure 13C (As shown in the diagram). For example, when each of the plurality of fold lines 531 is folded, the insert 504 can stand upright. Figure 13CThe assembly configuration shown.

[0146] like Figure 12B , Figure 13B and Figure 13C As shown, the insert 504 includes a top wall 510b, a second bottom wall 510d, a second front wall 510c, a second rear wall 510a, and an intermediate wall 510f positioned between the top wall 510b and the second bottom wall 510d. Once each of walls 510a to 510g is folded in place, wall 510e can be secured to the inner surface of the second rear wall 510a, and wall 510g can be secured to the inner surface of the second front wall 510c to secure the insert 504 in the assembly configuration. In some embodiments, walls 510e and 510g can be glued to the inner surfaces of the second rear wall 510a and the second front wall 510c, respectively. In other embodiments, walls 510e and 510g can be secured to the inner surfaces of the second rear wall 510a and the second front wall 510c, respectively, via interlocking slots, other adhesives, or other known methods for assembling the box and insert.

[0147] When the insert 504 is folded from its storage configuration (where the insert 504 is substantially flat) to its assembly configuration, the insert 504 can be configured to be disposed within the cavity 505 of the bottom box body 503 of the paper box 502, such as Figure 13B As shown. When the insert 504 is disposed within the cavity 505 of the bottom box body 503 of the carton 502, the second bottom wall 510d is configured to abut the first bottom wall 516, the second rear wall 510a is configured to abut the first rear wall 513a, and the second front wall 510c is configured to abut the first front wall 513c. In some embodiments, the insert 504 may be removably disposed within the cavity 505 of the bottom box body 503. In other embodiments, the insert 504 may be secured to the cavity 505 of the bottom box body 503 via glue, other adhesives, or other known methods for assembling boxes, cartons, and trays.

[0148] The top wall 510b of the insert 504 may define a cavity 506, which is sized, sized, and configured to receive a container, such as a container 508. When the container 508 is disposed within the cavity 506 of the insert 504, the bottom surface 508a of the container 508 may abut against the intermediate wall 510f of the insert 504. Therefore, the intermediate wall 510f of the insert 504 may be configured to support the container 508 within the insert 504. In some embodiments, the cavity 506 may be sized, sized, and configured to receive the neck of the container 508, such as the neck of a glass vial. Additionally or alternatively, such as Figure 13BAs shown, cavity 506 can be sized, sized, and configured to house the body of container 508, such as the body of a glass vial. In some embodiments, the size of container 508 can be indicated by ISO 8362-1. For example, container 508 can include a vial, and the vial can be one of ISO 2R vials, ISO 6R vials, ISO 10R vials, ISO 20R vials, or ISO 50R vials. In some embodiments, the vial can be filled or pre-filled with a drug. The drug can include, for example, talatumab (AMG 757) or another product containing a half-life-extended (HLE) anti-δ-like ligand 3 (DLL3) x anti-CD3 bispecific T-cell conjugate construct.

[0149] In some embodiments, when the insert 504 is disposed within the bottom housing 503 of the paper tray 502, one or more booklets 540 (in) Figure 13A and Figure 13B (As shown in the diagram) It can be disposed within the cavity 505 of the bottom housing 503. One or more brochures 540 may include, for example, user manuals, instruction manuals, patient information brochures, consumer drug information, or any other documents providing information about the drugs or medicines contained in the container 508 or the delivery of such drugs or medicines.

[0150] Figure 14A This is a plan view of a die-cut portion of a cardboard box 602 for packaging multiple containers according to various embodiments of this disclosure. The cardboard box 602 may be made of a single material. For example, the cardboard box 602 may be made of cardboard, corrugated cardboard, cardboard, or similar materials. In some embodiments, the cardboard box 602 may be made of a combination of natural and synthetic materials. In other embodiments, the cardboard box 602 may be made of several pieces glued together or otherwise secured together. The cardboard box 602 includes a plurality of fold lines 630 that divide the cardboard box 602 into a plurality of walls and flaps. Figure 14A A paper box 602 in a storage configuration is shown, wherein the paper box 602 is substantially or completely flat. The paper box 602 can be stored in a substantially flat storage configuration (such as...). Figure 14A (As shown) Stand up or fold into an assembled configuration (such as) Figure 15A (As shown). For example, when each of the multiple fold lines 630 has been folded, the cardboard box 602 can be erected into an assembly configuration to form a box-shaped cardboard box, such as... Figure 15A As shown.

[0151] refer to Figure 14A , Figure 15A , Figure 15B The cardboard box 602 includes a bottom box body 603 (in Figure 15AAs shown in the diagram, the bottom box has a first bottom wall 616, a first side wall 613b, a second side wall 613d, a first rear wall 613a, and a first front wall 613c, all formed by a plurality of flaps 616a to 616d. The flaps 616a to 616d can be secured to each other via interlocking slots, other adhesives, or other known methods of assembling boxes and cartons to form the first bottom wall 616 when the cartons 602 are assembled. The first rear wall 613a includes a flap 626, which can be, for example, glued to the inner surface of the second side wall 613d to form the bottom box 603. In some embodiments, the first rear wall 613a can be secured to the second side wall 613d via interlocking slots, other adhesives, or other known methods of assembling boxes and cartons. Thus, the first side wall 613b, the second side wall 613d, the first rear wall 613a, the first front wall 613c, and the first bottom wall 616 are all secured together to form the bottom box 603.

[0152] Furthermore, the carton 602 includes a lid 614 hinged to or coupled to the first rear wall 613a. In some embodiments, the lid 614 is a top cover movable between an open position and a closed position and includes a flap 615. When the carton 602 is assembled, the lid 614 can be moved from an open position, accessible to the interior of the bottom box 603, to a closed position, inaccessible to the interior of the bottom box 603. Additionally, the flap 615 of the lid 614 can be folded and tucked behind the first front wall 613c to secure the carton 602 in the closed position and prevent accidental opening of the carton 602.

[0153] Furthermore, the cardboard box 602 may include a first flap 607a and a second flap 607b extending from a first sidewall 613b and a second sidewall 613d of the bottom box body 603, respectively. The second sidewall 613d is positioned opposite to and facing the first sidewall 613b. In other words, the first sidewall 613b and the second sidewall 613d are opposing walls of the bottom box body 603. The first flap 607a may include a tab 625a at one end, and the second flap 607b may also include a tab 625b at one end. When the cardboard box 602 is folded into an assembled configuration along a plurality of fold lines 630, the tabs 625a and 625b may be secured to the inner surfaces of the first sidewall 613b and the second sidewall 613d, respectively, such that the first flap 607a and the second flap 607b define a set of cavities 609 (in Figure 15A(As shown in the figure). In some embodiments, tabs 625a and 625b may be glued to the inner surfaces of the first sidewall 613b and the second sidewall 613d, respectively. In other embodiments, tabs 625a and 625b may be secured to the inner surfaces of the first sidewall 613b and the second sidewall 613d, respectively, via interlocking slits, other adhesives, or other known methods of assembling boxes and cartons. When the carton 602 is assembled, the set of cavities 609 defined by the first flap 607a and the second flap 607b may include rectangular air cavities. In some embodiments, the set of cavities 609 may be configured to protect one or more containers disposed within the bottom box body 603 from top load impacts.

[0154] In some embodiments, the bottom housing 603 of the cardboard box 602 includes a release tab 662. For example... Figure 14A As shown, for example, the first front wall 613c includes a perforated line 660 surrounding a release tab 662, the perforated line being adjacent to the bottom edge 664 of the first front wall 613c. The release tab 662 is surrounded by the perforated line 660 and the bottom edge 664. The release tab 662 includes a first kiss-shaped cut 666. In some embodiments, an adhesive (such as an adhesive label) may be positioned on at least a portion of the release tab 662. The first kiss-shaped cut 666 may improve the fixation between the release tab 662 and the adhesive. When sufficient force is applied to the release tab 662, the perforated line 660 allows the release tab 662 to be detached from the first front wall 613c. Figure 14A As shown, the release tab 662 is a partially rectangular shape with rounded edges; however, the release tab 662 can be any shape of various shapes (including semicircles, triangles, quadrilaterals, pentagons, etc.).

[0155] In addition or alternatively, such as Figure 14A As shown, the cover 614 of the bottom housing 603 may also include a perforated line 680 surrounding the release tab 682, the perforated line being adjacent to the edge 684 between the cover 614 and the flap 615 of the cover. The release tab 682 is surrounded by the perforated line 680 and the edge 684. When sufficient force is applied to the release tab 682, the perforated line 680 allows the release tab 682 to be removed from the cover 614. Figure 14A As shown, the release tab 682 is a partially rectangular shape with rounded edges; however, the release tab 682 can be any shape of various shapes (including semicircles, triangles, quadrilaterals, pentagons, etc.).

[0156] In some embodiments, when the carton 602 is folded into an assembled configuration and the cover 640 is placed on the bottom housing 603, the position of the release tab 682 on the cover 614 can be aligned with the position of the release tab 662 on the first front wall 613c of the bottom housing 603, such that the release tabs 682 and 662 are positioned perpendicular to each other. Edges 684 and 664 that partially define the release tabs 682 and 662, respectively, can be aligned with each other and positioned adjacent to each other. In some embodiments, the release tabs 682 and / or 662 can be push tabs that detach the release tabs from the cover 614 and / or the first front wall 613c of the bottom housing 603. In some embodiments, adhesive (such as an adhesive label) can be positioned on the release tabs 682 and / or 662. Therefore, the release tabs 682 and / or 662 can include kiss-shaped cuts 668, 666 to improve the retention between the release tabs and the adhesive.

[0157] Release tabs 682 and 662 may be partially externally connected by perforated lines 680 and 660, respectively. Perforated lines 680 and 660 may each consist of a series of cuts. Kiss-shaped cuts 668 and 666 may each be portions passing through release tabs 682 and 662, respectively, which improve the adhesion between release tabs 682, 662 and the tamper-evident seal by increasing the surface area to which the tamper-evident seal can adhere. The tamper-evident seal may be, for example, an adhesive seal, such as an adhesive or sealing label for sealing carton 602. For example, adhesive may be placed on the kiss-shaped cut 668 on the lid 614 and the kiss-shaped cut 666 on the first front wall 613c of the bottom carton 603 to seal carton 602 in a closed position. Adhesive can act as a tamper-evident seal. That is, any attempt to peel the adhesive off carton 602 will result in visible damage to carton 602 and / or the adhesive. For example, when the lid 614 is in the closed position and the cardboard box 602 is sealed, release tabs 682 and 662 can be secured to the lid 614 and the first front wall 613c, respectively. When a person attempts to peel the adhesive off the cardboard box 602 and the lid 614 is in the open position, one or both of the release tabs 682 and 662 can be separated from the lid 614 and / or the first front wall 613c along the corresponding perforation lines 680, 660. In some embodiments, when a person attempts to peel the adhesive off the cardboard box 602, one of the release tabs 682 and 662 can be separated from one of the lid 614 and the first front wall 613c along the corresponding perforation lines 680, 660, and can be secured to the other of the lid 614 and the first front wall 613c via adhesive.

[0158] Figure 14BThis is a plan view of a punched piece of an insert 604 configured to be disposed within the bottom body 603 of a cardboard box 602, according to various embodiments of this disclosure. The insert 604 may be made of a single material. For example, the insert 604 may be made of cardboard, corrugated cardboard, cardboard, or similar materials. In some embodiments, the insert 604 may be made of a combination of natural and synthetic materials. In other embodiments, the insert 604 may be made of several pieces glued together or otherwise fixed together. Figure 14B As shown, the insert 604 includes a plurality of fold lines 631, thereby dividing the insert 604 into a plurality of walls 610a to 610h. Figure 14B The insert 604 is shown in a flat configuration. Similar to the cardboard box 602, the insert 604 is located in a substantially flat storage configuration (in...). Figure 14B (As shown in the image) Stand up and assemble into a configuration (in) Figure 15B (As shown in the diagram). For example, when each of the plurality of fold lines 631 is folded, the insert 604 can stand upright. Figure 15B The assembly configuration shown.

[0159] Insert 604 includes a top wall 610b, a second bottom wall 610d, a second front wall 610c, a second rear wall 610a, a first intermediate wall 610f positioned between the top wall 610b and the second bottom wall 610d, and a second intermediate wall 610h positioned between the top wall 610b and the second bottom wall 610d. The heights of the first intermediate wall 610f and the second intermediate wall 610h can be offset. For example, during assembly, the first intermediate wall 610f can be positioned higher than the second intermediate wall 610h. Once each of walls 610a to 610h is folded in place, wall 610e can be secured to the inner surface of the second rear wall 610a, and wall 610g can be secured to the inner surface of the second front wall 610c to secure insert 604 in the assembled configuration. In some embodiments, walls 610e and 610g can be glued to the inner surfaces of the second rear wall 610a and the second front wall 610c, respectively. In other embodiments, walls 610e and 610g may be secured to the inner surfaces of the second rear wall 610a and the second front wall 610c, respectively, via interlocking slits, other adhesives, or other known methods of assembling boxes and inserts.

[0160] When the insert 604 is folded from its storage configuration (where the insert 604 is substantially flat) to its assembly configuration, the insert 604 can be configured to be disposed within the cavity 605 of the bottom box body 603 of the cardboard box 602, such as Figure 15BAs shown. When the insert 604 is disposed within the cavity 605 of the bottom box body 603 of the carton 602, the second bottom wall 610d is configured to abut the first bottom wall 616, the second rear wall 610a is configured to abut the first rear wall 613a, and the second front wall 610c is configured to abut the first front wall 613c. In some embodiments, the insert 604 may be removably disposed within the cavity 605 of the bottom box body 603. In other embodiments, the insert 604 may be secured to the cavity 605 of the bottom box body 603 via glue, other adhesives, or other known methods of assembling boxes, cartons, and trays.

[0161] The top wall 610b of the insert 604 may define a first cavity 606a, which is sized and configured to receive a first container (such as container 608a); and a second cavity 606b, which is sized and configured to receive a second container (such as container 608b). When the first container 608a and the second container 608b are respectively disposed within the first cavity 606a and the second cavity 606b, the bottom surface of the first container 608a may abut against the first intermediate wall 610f, and the bottom surface of the second container 608b may abut against the second intermediate wall 610h. Therefore, the first intermediate wall 610f and the second intermediate wall 610h of the insert 604 may be configured to support the first container 608a and the second container 608b within the insert 604, respectively.

[0162] like Figure 14BAs shown, the diameter of the first cavity 606a can be smaller than the diameter of the second cavity 606b to accommodate containers of different sizes within a single package. For example, the diameter of the first container 608a can be smaller than the diameter of the second container 608b. The first container 608a can be one of an ISO 2R vial, an ISO 6R vial, an ISO 10R vial, an ISO 20R vial, or an ISO 50R vial, and the second container 608b can be another of an ISO 2R vial, an ISO 6R vial, an ISO 10R vial, an ISO 20R vial, or an ISO 50R vial. In one embodiment, for example, the first container 608a can be an ISO 20R vial, and the second container 608b can be an ISO 50R vial. As discussed above, since the dimensions (e.g., diameter, height, etc.) of the first container 608a and the second container 608b may differ, the heights of the first intermediate wall 610f and the second intermediate wall 610h can be offset. For example, the first intermediate wall 610f can be positioned higher than the second intermediate wall 610h in the insert 604. Therefore, even if the height of the first container 608a is shorter than the height of the second container 608b, the first container 608a and the second container 608b can still be positioned at the same or similar heights within the insert 604 because the first intermediate wall 610f and the second intermediate wall 610h, which respectively support the first container 608a and the second container 608b, are offset.

[0163] In some embodiments, cavities 606a and 606b may each be sized and configured to respectively accommodate the necks of containers 608a and 608b. Additionally or alternatively, such as Figure 15A and Figure 15B As shown, cavities 606a and 606b can each be defined in size and configured to accommodate the bodies of containers 608a and 608b, respectively. In some embodiments, the first container 608a and the second container 608b may include vials filled or pre-filled with a drug. The drug may include, for example, talatumab (AMG757) or another product containing a half-life-extended (HLE) anti-δ-like ligand 3 (DLL3) x anti-CD3 bispecific T-cell conjugate construct. In some embodiments, the first container 608a and the second container 608b may include vials filled or pre-filled with different drugs.

[0164] In some embodiments, when the insert 604 is disposed within the bottom housing 603 of the paper tray 602, one or more booklets 640 (in) Figure 15A (As shown in the diagram) can be disposed within the cavity 605 of the bottom housing 603 (in Figure 15B(As shown in the diagram). One or more brochures 640 may include, for example, user manuals, instruction manuals, patient information brochures, consumer drug information, or any other documents providing information about the drugs or medicines contained in containers 608a, 608b or the delivery of such drugs or medicines.

[0165] Figure 16A This is a plan view of a die-cut portion of a cardboard box 702 for packaging multiple containers according to various embodiments of this disclosure. The cardboard box 702 may be made of a single material. For example, the cardboard box 702 may be made of cardboard, corrugated cardboard, cardboard, or similar materials. In some embodiments, the cardboard box 702 may be made of a combination of natural and synthetic materials. In other embodiments, the cardboard box 702 may be made of several pieces glued together or otherwise secured together. The cardboard box 702 includes a plurality of fold lines 730 that divide the cardboard box 702 into a plurality of walls and flaps. Figure 16A A paper box 702 in a storage configuration is shown, wherein the paper box 702 is substantially or completely flat. The paper box 702 can be stored in a substantially flat storage configuration (in... Figure 16A (as shown in the image) stand up or fold into an assembled configuration (in...) Figure 17A and Figure 17B (As shown in the diagram). For example, when each of the multiple fold lines 730 has been folded, the cardboard box 702 can be erected into an assembly configuration to form a box-shaped cardboard box, such as... Figure 17A and Figure 17B As shown.

[0166] refer to Figure 16A , Figure 17A and Figure 17B The cardboard box 702 includes the bottom box body 703 (in Figure 17A and Figure 17B As shown in the diagram, the bottom box has a first bottom wall 716, a first side wall 713b, a second side wall 713d, a first rear wall 713a, and a first front wall 713c, all formed by a plurality of flaps 716a to 716d. The flaps 716a to 716d can be secured to each other via interlocking slots, other adhesives, or other known methods of assembling boxes and cartons to form the first bottom wall 716 when the cartons 702 are assembled. The first rear wall 713a includes a flap 726, which can be, for example, glued to the inner surface of the second side wall 713d to form the bottom box 703. In some embodiments, the first rear wall 713a can be secured to the second side wall 713d via interlocking slots, other adhesives, or other known methods of assembling boxes and cartons. Thus, the first side wall 713b, the second side wall 713d, the first rear wall 713a, the first front wall 713c, and the first bottom wall 716 are all secured together to form the bottom box 703.

[0167] Furthermore, the carton 702 includes a lid 714 hinged to or coupled to the first rear wall 713a. In some embodiments, the lid 714 is a top cover movable between an open position and a closed position and includes a flap 715. When the carton 702 is assembled, the lid 714 can be moved from an open position, accessible to the interior of the bottom box 703, to a closed position, inaccessible to the interior of the bottom box 703. Additionally, the flap 715 of the lid 714 can be folded and tucked behind the first front wall 713c to secure the carton 702 in the closed position and prevent accidental opening of the carton 702.

[0168] Furthermore, the cardboard box 702 may include a first flap 707a and a second flap 707b extending from a first sidewall 713b and a second sidewall 713d, respectively, of the bottom box body 703. The second sidewall 713d is positioned opposite to and facing the first sidewall 713b. In other words, the first sidewall 713b and the second sidewall 713d are opposing walls of the bottom box body 703.

[0169] In some embodiments, the bottom housing 703 of the cardboard box 702 includes a release tab 762. For example... Figure 16A As shown, for example, the first front wall 713c includes a perforated line 760 surrounding the release tab 762, the perforated line being adjacent to the bottom edge 764 of the first front wall 713c. The release tab 762 is surrounded by the perforated line 760 and the bottom edge 764. The release tab 762 includes a first kiss-shaped cut 766. In some embodiments, an adhesive (such as an adhesive label) may be positioned on at least a portion of the release tab 762. The first kiss-shaped cut 766 may improve the fixation between the release tab 762 and the adhesive. When sufficient force is applied to the release tab 762, the perforated line 760 allows the release tab 762 to be detached from the first front wall 713c. Figure 16A As shown, the release tab 762 is a partially rectangular shape with rounded edges; however, the release tab 762 can be any shape of various shapes (including semicircles, triangles, quadrilaterals, pentagons, etc.).

[0170] In addition or alternatively, such as Figure 16A As shown, the cover 714 of the bottom housing 703 may also include a perforated line 780 surrounding the release tab 782, the perforated line being adjacent to the edge 784 between the cover 714 and the flap 715 of the cover. The release tab 782 is surrounded by the perforated line 780 and the edge 784. When sufficient force is applied to the release tab 782, the perforated line 780 allows the release tab 782 to be removed from the cover 714. Figure 16A As shown, the release tab 782 is a partially rectangular shape with rounded edges; however, the release tab 782 can be any shape of various shapes (including semicircles, triangles, quadrilaterals, pentagons, etc.).

[0171] In some embodiments, when the carton 702 is folded into an assembled configuration and the cover 740 is placed on the bottom housing 703, the position of the release tab 782 on the cover 714 can be aligned with the position of the release tab 762 on the first front wall 713c of the bottom housing 703, such that the release tabs 782 and 762 are positioned perpendicular to each other. Edges 784 and 764 that partially define the release tabs 782 and 762, respectively, can be aligned with each other and positioned adjacent to each other. In some embodiments, the release tabs 782 and / or 762 can be push tabs that detach the release tabs from the cover 714 and / or the first front wall 713c of the bottom housing 703. In some embodiments, adhesive (such as an adhesive label) can be positioned on the release tabs 782 and / or 762. Therefore, the release tabs 782 and / or 762 can include kiss-shaped cuts 768, 766 to improve the fixation between the release tabs and the adhesive.

[0172] Release tabs 782 and 762 may be partially externally connected by perforated lines 780 and 760, respectively. Perforated lines 780 and 760 may each consist of a series of cuts. Kiss-like cuts 768 and 766 may each be portions passing through release tabs 782 and 762, respectively, which improve the adhesion between release tabs 782, 762 and the tamper-evident seal by increasing the surface area to which the tamper-evident seal can adhere. The tamper-evident seal may be, for example, an adhesive seal, such as an adhesive or sealing label for sealing carton 702. For example, adhesive may be placed on the kiss-like cut 768 on the lid 714 and the kiss-like cut 766 on the first front wall 713c of the bottom carton 703 to seal carton 702 in a closed position. Adhesive may act as the tamper-evident seal. That is, any attempt to peel the adhesive off carton 702 will result in visible damage to carton 702 and / or the adhesive. For example, when the lid 714 is in the closed position and the cardboard box 602 is sealed, release tabs 782 and 762 can be secured to the lid 714 and the first front wall 713c, respectively. When a person attempts to peel the adhesive off the cardboard box 702 and the lid 714 is in the open position, one or both of the release tabs 782 and 762 can be separated from the lid 714 and / or the first front wall 713c along the corresponding perforation lines 780, 760. In some embodiments, when a person attempts to peel the adhesive off the cardboard box 702, one of the release tabs 782 and 762 can be separated from one of the lid 714 and the first front wall 713c along the corresponding perforation lines 780, 760, and can be secured to the other of the lid 714 and the first front wall 713c via adhesive.

[0173] In some embodiments, the cardboard box 702 may further include a tray 791, which is hingedly connected to the bottom box body 703 and movable between a first position and a second position. Figure 16A , Figure 17A and Figure 17B As shown, the tray 791 may include a plurality of sidewalls 791a to 791d and may be hingedly connected to the first front wall 713c via sidewall 791c. Figure 17A The image shows tray 791 in a first (open) position, in which cavity 705 of bottom housing 703 is accessible, and Figure 17B The tray 791 is shown in a second (closed) position, in which the cavity 705 of the bottom box 703 is no longer accessible. When the tray 791 is in the second (closed) position, multiple sidewalls 791a to 791d can be folded upward along multiple fold lines 730 to define a second bottom box disposed within the bottom box 703. The tray 791 may define the second bottom box, which is configured to receive or contain one or more objects, such as one or more brochures. For example, the tray 791 may be configured to receive or contain user manuals, instruction manuals, patient information brochures, consumer drug information, or any other documents providing information about drugs or medications contained in one or more containers packaged within the carton 702, or the delivery of such drugs or medications.

[0174] In some embodiments, tray 791 may include a perforated line 790 surrounding release tab 792, the perforated line being adjacent to the edge 794 of tray 791. Release tab 792 is surrounded by the perforated line 790 and the bottom edge 794. The perforated line 790 may consist of a series of cuts. When sufficient force is applied to release tab 792, the perforated line 790 allows release tab 792 to be detached from tray 791. Therefore, release tab 792 can be detached from tray 791, allowing tray 791 to be lifted into the cavity 705 of bottom housing 703, such as... Figure 17A As shown. Figure 16A As shown, the release tab 792 is a partially rectangular shape with rounded edges; however, the release tab 792 can be any shape of various shapes (including semicircles, triangles, quadrilaterals, pentagons, etc.).

[0175] Figure 16BThis is a plan view of a punched portion of an insert 704 configured to be disposed within a cavity 705 of the bottom housing 703 of a cardboard box 702, according to various embodiments of this disclosure. The insert 704 may be made of a single material. For example, the insert 704 may be made of cardboard, corrugated cardboard, cardboard, or similar materials. In some embodiments, the insert 704 may be made of a combination of natural and synthetic materials. In other embodiments, the insert 704 may be made of several pieces glued together or otherwise fixed together. Figure 16B As shown, the insert 704 includes a plurality of fold lines 731, thereby dividing the insert 704 into a plurality of walls 710a to 710i. Figure 16B The insert 704 is shown in a flat configuration. Similar to the cardboard box 702, the insert 704 is located in a substantially flat storage configuration (in...). Figure 16B (As shown in the image) Stand up and assemble into a configuration (in) Figures 18A to 18D (As shown in the diagram). For example, when each of the plurality of fold lines 731 is folded, the insert 704 can stand upright. Figures 18A to 18D The assembly configuration shown.

[0176] Insert 704 includes a top wall 710b, a second bottom wall 710d, a second front wall 710c, a second rear wall 710a, a first intermediate wall 710f positioned between the top wall 710b and the second bottom wall 710d, and a second intermediate wall 710h positioned between the first intermediate wall 710f and the second bottom wall 710d. During assembly, the first intermediate wall 710f can be positioned higher than the second intermediate wall 710h, such as... Figure 18B As shown. Once each of the walls is folded along the fold line 731, wall 710e can be secured to the inner surface of the second rear wall 710a, wall 710g can be secured to the inner surface of the second front wall 710c, and wall 710i can be secured to the inner surface of wall 710e to secure insert 704 in the assembly configuration. In some embodiments, walls 710e, 710g, and 710i can be glued to the inner surfaces of the second rear wall 710a, the second front wall 710c, and wall 710e, respectively. In other embodiments, walls 710e, 710g, and 710i can be secured to the inner surfaces of the second rear wall 710a, the second front wall 710c, and wall 710e, respectively, via interlocking slits, other adhesives, or other known methods for assembling the box and insert.

[0177] like Figure 16BAs shown, the insert 704 may include a first pair of opposing flaps 710n connected to the second front wall 710c and a second pair of opposing flaps 710m connected to the second rear wall 710a. Furthermore, the top wall 710b may include a third pair of opposing flaps 710j hingedly connected to the top wall 710b. The third pair of opposing flaps 710j is movable between an open position and a closed position. For example, the third pair of opposing flaps 710j may fold from the open position to the closed position along the fold line 731. Each of the third pair of opposing flaps 710j may include a flap 710k.

[0178] As part of the assembly process, the first pair of opposing flaps 710n and the second pair of opposing flaps 710m can be folded along the fold line 731, and the third pair of opposing flaps 710j can be folded along the fold line 731 to cover the first pair of opposing flaps 710n and the second pair of opposing flaps 710m. In the closed position, the third pair of opposing flaps 710j can define the third and fourth sidewalls of the insert 704. Afterwards, flaps 710k can be folded and inserted into the second bottom wall 710d (e.g., ...). Figure 18D (As shown), to secure the insert 704 in the closed position, such as at least Figure 18A and Figure 18D As shown.

[0179] When the insert 704 is folded from its storage configuration (where the insert 704 is substantially flat) to its assembly configuration, the insert 704 can be disposed within the cavity 705 of the bottom box body 703 of the cardboard box 702, such as Figure 17A As shown. When the insert 704 is disposed within the cavity 705 of the bottom box body 703 of the cardboard box 702, the second bottom wall 710d is configured to abut the first bottom wall 716, the second rear wall 710a is configured to abut the first rear wall 713a, and the second front wall 710c is configured to abut the first front wall 713c. In some embodiments, the insert 704 may be removably disposed within the cavity 705 of the bottom box body 703. In other embodiments, the insert 704 may be secured to the cavity 705 of the bottom box body 703 via glue, other adhesives, or other known methods of assembling boxes, cartons, and trays. Once the insert 704 is disposed within the cavity 705, the tray 791 can be moved from a first position to a second position (in Figure 17B (as shown in the figure), such that the tray 791 sits on top of the insert 704 and covers the insert 704.

[0180] The top wall 710b of the insert 704 may define a plurality of cavities 706a to 706c, each cavity being sized, defined, and configured to receive a corresponding container. Furthermore, the first intermediate wall 710f may define a plurality of cavities 706d to 706e. In some embodiments, the number of cavities defined by the top wall 710b may differ from the number of cavities defined by the first intermediate wall 710f. For example, as... Figure 16B As shown, the top wall 710b may define three cavities 706a to 706c, while the first intermediate wall 710f may define two cavities 706d to 706e. In other embodiments, the number of cavities defined by the top wall 710b may be equal to the number of cavities defined by the first intermediate wall 710f. In some embodiments, each of the plurality of cavities 706a to 706e may have the same dimensions (e.g., diameter) and can therefore be sized, sized, and configured to receive containers having the same dimensions (e.g., diameter, height, etc.). In other embodiments, at least one of the plurality of cavities 706a to 706e may have different dimensions, such as different diameters, than the remaining cavities 706a to 706e. For example, cavities 706a, 706b, 706d, and 706e may have the same diameter and therefore may each be sized, dimensioned, and configured to receive ISO 2R vials, while cavity 706c may have a larger diameter than cavities 706a, 706b, 706d, and 706e and therefore may be sized, dimensioned, and configured to receive ISO 6R vials.

[0181] In some embodiments, when the insert 704 is in the assembled configuration, the positions of the cavities 706d and 706e in the first intermediate wall 710f can be vertically aligned with the positions of the cavities 706a and 706b in the top wall 710b, respectively. Therefore, when the container is disposed within the cavities 706a and 706b, each container will be assembled through the cavities 706a and 706b in the top wall 710b and the corresponding cavities 706d and 706e in the first intermediate wall 710f. When the container is disposed within the cavities 706a and 706b in the top wall 710b and the corresponding cavities 706d and 706e in the first intermediate wall 710f, the bottom surface of the container can abut against the second intermediate wall 710h. When the container is disposed within the cavity 706c of the top wall, the bottom surface of the container can abut against the first intermediate wall 710f. Therefore, at least one of the first intermediate wall 710f or the second intermediate wall 710h can be configured to abut the bottom surface of the container and support the container when the container is received in the insert 704.

[0182] In some embodiments, the insert 704 may further include a vertical rib support 721 extending between the second intermediate wall 710h and the second bottom wall 710d, such as Figure 18CAs shown. The vertical rib support 721 can be integrally formed with the insert 704. The vertical rib support 721 can be configured to maintain a predefined distance between the second intermediate wall 710h and the second bottom wall 710d, such that the container received within the insert 704 is always raised from the second bottom wall 710d of the insert 704 and supported by at least one of the first intermediate wall 710f or the second intermediate wall 710h of the insert 704. Therefore, the vertical rib support 721 can ensure that the container received within the insert 704 is protected from bottom load impacts. In addition, the vertical rib support 721 can be configured to at least help the second intermediate wall 710h support the weight of the container.

[0183] In some embodiments, the second intermediate wall 710h may include a set of flaps 710p extending from the opposite side of the second intermediate wall 710h, such as Figure 16B As shown. Once the insert 704 is folded into the assembled configuration, the flap 710p can be folded upwards or downwards (as shown). Figure 18B and Figure 18C (As shown). When folded upwards or downwards, flap 710p can be configured to provide additional stiffness to insert 704, so that insert 704 can maintain its box shape when folded into its assembled configuration.

[0184] As discussed above, in some embodiments, the diameters of cavities 706a to 706e may be different to accommodate containers of different sizes within a single insert and a single package. For example, the diameters of cavities 706a, 706b, 706d, and 706e may be smaller than the diameter of cavity 706c, and therefore, the diameter of the first set of containers received within cavities 706a, 706b, 706d, and 706e may be smaller than the diameter of the second container received within cavity 706c. The first set of containers may, for example, be one of ISO 2R vials, ISO 6R vials, ISO 10R vials, ISO 20R vials, or ISO 50R vials, and the second container may be another of ISO 2R vials, ISO 6R vials, ISO 10R vials, ISO 20R vials, or ISO 50R vials. In one embodiment, for example, the first set of containers may be ISO 2R vials, and the second container may be ISO 6R vials. As discussed above, since the dimensions of the containers (e.g., diameter, height, etc.) may differ, the heights of the first intermediate wall 710f and the second intermediate wall 710h can be offset. For example, the first intermediate wall 710f can be positioned higher than the second intermediate wall 710h within the insert 704. Therefore, even if the height of the first set of containers received within cavities 706a, 706b, 706d, and 706e may be greater than the height of the second container received within cavity 706c, all containers can still be positioned at the same or similar heights within the insert 704 because the first intermediate wall 710f and the second intermediate wall 710h supporting the containers are offset.

[0185] In some embodiments, cavities 706a to 706e may each be sized and configured to receive the neck of a container received within insert 704. In other embodiments, cavities 706a to 706e may each be sized and configured to receive the body of a container received within insert 704. In yet another embodiment, some of cavities 706a to 706e may be sized and configured to receive the neck of a container, while others may be sized and configured to receive the body of a container. In some embodiments, the container received within insert 704 may include a vial filled or pre-filled with a drug. The drug may include, for example, talatumab (AMG757) or another product comprising a half-life-extended (HLE) anti-δ-like ligand 3 (DLL3) x anti-CD3 bispecific T-cell conjugate. In some embodiments, at least one of the containers received within the insert 704 may be a medicine bottle filled or prefilled with a drug different from the drugs contained in the other containers.

[0186] Figure 19AThis is a plan view of a die-cut portion of a cardboard box 802 for packaging multiple containers according to various embodiments of this disclosure. The cardboard box 802 may be made of a single material. For example, the cardboard box 802 may be made of cardboard, corrugated cardboard, cardboard, or similar materials. In some embodiments, the cardboard box 802 may be made of a combination of natural and synthetic materials. In other embodiments, the cardboard box 802 may be made of several pieces glued together or otherwise secured together. The cardboard box 802 includes a plurality of fold lines 830 that divide the cardboard box 802 into a plurality of walls and flaps. Figure 19A A paper box 802 in a storage configuration is shown, wherein the paper box 802 is substantially or completely flat. The paper box 802 can be stored in a substantially flat storage configuration (in... Figure 19A (as shown in the image) stand up or fold into an assembled configuration (in...) Figure 20A and Figure 20B (As shown in the diagram). For example, when each of the multiple fold lines 830 has been folded, the cardboard box 802 can be erected into an assembly configuration to form a box-shaped cardboard box, such as... Figure 20A and Figure 20B As shown.

[0187] refer to Figure 19A , Figure 20A and Figure 20B The cardboard box 802 includes the bottom box body 803 (as in...). Figure 20A and Figure 20B As shown in the diagram, the bottom box has a first bottom wall 816, a first side wall 813b, a second side wall 813d, a first rear wall 813a, and a first front wall 813c, all formed by a plurality of flaps 816a to 816d. The flaps 816a to 816d can be secured to each other via interlocking slots, other adhesives, or other known methods of assembling boxes and cartons to form the first bottom wall 816 when the cartons 802 are assembled. The first rear wall 813a includes a flap 826, which can be, for example, glued to the inner surface of the second side wall 813d to form the bottom box 803. In some embodiments, the first rear wall 813a can be secured to the second side wall 813d via interlocking slots, other adhesives, or other known methods of assembling boxes and cartons. Thus, the first side wall 813b, the second side wall 813d, the first rear wall 813a, the first front wall 813c, and the first bottom wall 816 are all secured together to form the bottom box 803.

[0188] Furthermore, the carton 802 includes a lid 814 hinged to or coupled to the first rear wall 813a. In some embodiments, the lid 814 is a top cover movable between an open position and a closed position and includes a flap 815. When the carton 802 is assembled, the lid 814 can be moved from an open position accessible to the interior cavity 805 of the bottom carton 803 to a closed position inaccessible to the interior cavity 805 of the bottom carton 803. Additionally, the flap 815 of the lid 814 can be folded and tucked behind the first front wall 813c to secure the carton 802 in the closed position and prevent accidental opening of the carton 802.

[0189] Furthermore, the cardboard box 802 may include a first flap 807a and a second flap 807b extending from a first sidewall 813b and a second sidewall 813d, respectively, of the bottom box body 803. The second sidewall 813d is positioned opposite to and facing the first sidewall 813b. In other words, the first sidewall 813b and the second sidewall 813d are opposing walls of the bottom box body 803.

[0190] In some embodiments, the bottom housing 803 of the cardboard box 802 includes a release tab 862. For example... Figure 19A As shown, for example, the first front wall 813c includes a perforated line 860 surrounding a release tab 862, the perforated line being adjacent to the bottom edge 864 of the first front wall 813c. The release tab 862 is surrounded by the perforated line 860 and the bottom edge 864. The release tab 862 includes a first kiss-shaped cut 866. In some embodiments, an adhesive (such as an adhesive label) may be positioned on at least a portion of the release tab 862. The first kiss-shaped cut 866 may improve the fixation between the release tab 862 and the adhesive. When sufficient force is applied to the release tab 862, the perforated line 860 allows the release tab 862 to be detached from the first front wall 813c. Figure 19A As shown, the release tab 862 is a partially rectangular shape with rounded edges; however, the release tab 862 can be any shape of various shapes (including semicircles, triangles, quadrilaterals, pentagons, etc.).

[0191] In addition or alternatively, such as Figure 19A As shown, the cover 814 of the bottom housing 803 may also include a perforated line 880 surrounding the release tab 882, the perforated line being adjacent to the edge 884 between the cover 814 and the flap 815 of the cover. The release tab 882 is surrounded by the perforated line 880 and the edge 884. When sufficient force is applied to the release tab 882, the perforated line 880 allows the release tab 882 to be removed from the cover 814. Figure 19A As shown, the release tab 882 is a partially rectangular shape with rounded edges; however, the release tab 882 can be any shape of various shapes (including semicircles, triangles, quadrilaterals, pentagons, etc.).

[0192] In some embodiments, when the carton 802 is folded into an assembled configuration and the cover 840 is placed on the bottom box 803, the release tab 882 on the cover 814 can be aligned with the release tab 862 on the first front wall 813c of the bottom box 803, such that the release tabs 882 and 862 are positioned perpendicular to each other. Edges 884 and 864 that partially define the release tabs 882 and 862, respectively, can be aligned with each other and positioned adjacent to each other. In some embodiments, the release tabs 882 and / or 862 can be push tabs that detach the release tabs from the cover 814 and / or the first front wall 813c of the bottom box 803. In some embodiments, adhesive (such as an adhesive label) can be positioned on the release tabs 882 and / or 862. Therefore, the release tabs 882 and / or 862 can include kiss-shaped cuts 868, 866 to improve the retention between the release tabs and the adhesive.

[0193] Release tabs 882 and 862 may be partially externally connected by perforated lines 880 and 860, respectively. Perforated lines 880 and 860 may each consist of a series of cuts. Kiss-shaped cuts 868 and 866 may each be portions passing through release tabs 882 and 862, respectively, which improve the adhesion between release tabs 882, 862 and the tamper-evident seal by increasing the surface area to which the tamper-evident seal can adhere. The tamper-evident seal may be, for example, an adhesive seal, such as an adhesive or sealing label for sealing carton 802. For example, adhesive may be placed on the kiss-shaped cut 868 on the lid 814 and the kiss-shaped cut 866 on the first front wall 813c of the bottom carton 803 to seal carton 802 in a closed position. Adhesive can act as a tamper-evident seal. That is, any attempt to peel the adhesive off carton 802 will result in visible damage to carton 802 and / or the adhesive. For example, when the lid 814 is in the closed position and the cardboard box 802 is sealed, release tabs 882 and 862 can be secured to the lid 814 and the first front wall 813c, respectively. When a person attempts to peel the adhesive off the cardboard box 802 and the lid 814 is in the open position, one or both of the release tabs 882 and 862 can be separated from the lid 814 and / or the first front wall 813c along the corresponding perforation lines 880, 860. In some embodiments, when a person attempts to peel the adhesive off the cardboard box 802, one of the release tabs 882 and 862 can be separated from one of the lid 814 and the first front wall 813c along the corresponding perforation lines 880, 860, and can be secured to the other of the lid 814 and the first front wall 813c via adhesive.

[0194] In some embodiments, the cardboard box 802 may further include a tray 891, which is hingedly connected to the bottom box body 803 and movable between a first position and a second position. Figure 19A , Figure 20A and Figure 20B As shown, the tray 891 may include a plurality of sidewalls 891a to 891d and may be hingedly connected to the first front wall 813c via sidewall 891c. Figure 20A The tray 891 is shown in a first (open) position, in which the cavity 805 of the bottom box 803 is accessible, and Figure 20B The tray 891 is shown in a second (closed) position, in which the cavity 805 of the bottom box 803 is no longer accessible. When the tray 891 is in the second (closed) position, multiple sidewalls 891a to 891d can be folded upward along multiple fold lines 830 to define a second bottom box disposed within the bottom box 803. The tray 891 may define the second bottom box, which is configured to receive or contain one or more objects, such as one or more brochures. For example, the tray 891 may be configured to receive or contain user manuals, instruction manuals, patient information brochures, consumer medication information, or any other documents providing information about medications or drugs contained in one or more containers packaged within the carton 802, or the delivery of such medications or drugs.

[0195] In some embodiments, tray 891 may include a perforated line 890 surrounding a release tab 892, the perforated line being adjacent to the edge 894 of tray 891. The release tab 892 is surrounded by the perforated line 890 and the bottom edge 894. The perforated line 890 may consist of a series of cuts. When sufficient force is applied to the release tab 892, the perforated line 890 allows the release tab 892 to be detached from tray 891. Therefore, the release tab 892 can be detached from tray 891, allowing tray 891 to be lifted into the cavity 805 of the bottom housing 803, such as... Figure 20A As shown. Figure 19A As shown, the release tab 892 is a partially rectangular shape with rounded edges; however, the release tab 892 can be any shape of various shapes (including semicircles, triangles, quadrilaterals, pentagons, etc.).

[0196] Figure 19BThis is a plan view of a punched piece of an insert 804 configured to be disposed within a cavity 805 of the bottom body 803 of a cardboard box 802, according to various embodiments of this disclosure. The insert 804 may be made of a single material. For example, the insert 804 may be made of cardboard, corrugated cardboard, cardboard, or similar materials. In some embodiments, the insert 804 may be made of a combination of natural and synthetic materials. In other embodiments, the insert 804 may be made of several pieces glued together or otherwise fixed together. Figure 19B As shown, the insert 804 includes a plurality of fold lines 831, thereby dividing the insert 804 into a plurality of walls 810a to 810i. Figure 19B The insert 804 is shown in a flat configuration. Similar to the cardboard box 802, the insert 804 is located in a substantially flat storage configuration (in...). Figure 19B (As shown in the image) Stand up and assemble into a configuration (in) Figures 21A to 21D (As shown in the diagram). For example, when each of the plurality of fold lines 831 is folded, the insert 804 can stand upright. Figures 21A to 21D The assembly configuration shown.

[0197] Insert 804 includes a top wall 810b, a second bottom wall 810d, a second front wall 810c, a second rear wall 810a, a first intermediate wall 810f positioned between the top wall 810b and the second bottom wall 810d, and a second intermediate wall 810h positioned between the first intermediate wall 810f and the second bottom wall 810d. During assembly, the first intermediate wall 810f can be positioned higher than the second intermediate wall 810h, such as... Figure 21B As shown. Once each of the walls is folded along the fold line 831, wall 810e can be secured to the inner surface of the second rear wall 810a, wall 810g can be secured to the inner surface of the second front wall 810c, and wall 810i can be secured to the inner surface of wall 810e to secure insert 804 in the assembly configuration. In some embodiments, walls 810e, 810g, and 810i can be glued to the inner surfaces of the second rear wall 810a, the second front wall 810c, and wall 810e, respectively. In other embodiments, walls 810e, 810g, and 810i can be secured to the inner surfaces of the second rear wall 810a, the second front wall 810c, and wall 810e, respectively, via interlocking slits, other adhesives, or other known methods for assembling the box and insert.

[0198] like Figure 19BAs shown, the insert 804 may include a first pair of opposing flaps 810n connected to the second front wall 810c and a second pair of opposing flaps 810m connected to the second rear wall 810a. Furthermore, the top wall 810b may include a third pair of opposing flaps 810j hingedly connected to the top wall 810b. The third pair of opposing flaps 810j is movable between an open position and a closed position. For example, the third pair of opposing flaps 810j may fold from the open position to the closed position along the fold line 831. Each of the third pair of opposing flaps 810j may include a flap 810k.

[0199] As part of the assembly process, the first pair of opposing flaps 810n and the second pair of opposing flaps 810m can be folded along the fold line 831, and the third pair of opposing flaps 810j can be folded along the fold line 831 to cover the first pair of opposing flaps 810n and the second pair of opposing flaps 810m. In the closed position, the third pair of opposing flaps 810j can define the third and fourth sidewalls of the insert 804. Afterwards, flaps 810k can be folded and inserted into the second bottom wall 810d (e.g., ...). Figure 21D (As shown), to secure the insert 804 in the closed position, such as at least Figure 21A and Figure 21D As shown.

[0200] When the insert 804 is folded from its storage configuration (in which the insert 804 is substantially flat) to its assembly configuration, the insert 804 can be disposed within the cavity 805 of the bottom box body 803 of the cardboard box 802, such as Figure 20A As shown. When the insert 804 is disposed within the cavity 805 of the bottom box body 803 of the carton 802, the second bottom wall 810d is configured to abut the first bottom wall 816, the second rear wall 810a is configured to abut the first rear wall 813a, and the second front wall 810c is configured to abut the first front wall 813c. In some embodiments, the insert 804 may be removably disposed within the cavity 805 of the bottom box body 803. In other embodiments, the insert 804 may be secured to the cavity 805 of the bottom box body 803 via glue, other adhesives, or other known methods of assembling boxes, cartons, and trays. Once the insert 804 is disposed within the cavity 805, the tray 891 can be moved from a first position to a second position (in Figure 20B (as shown in the figure), such that the tray 891 sits on top of the insert 804 and covers the insert 804.

[0201] The top wall 810b of the insert 804 may define a plurality of cavities 806a to 806c, each cavity being sized, defined, and configured to receive a corresponding container. Furthermore, the first intermediate wall 810f may define a plurality of cavities 806d to 806f. In some embodiments, the number of cavities defined by the top wall 810b may differ from the number of cavities defined by the first intermediate wall 810f. In some embodiments, the number of cavities defined by the top wall 810b may be equal to the number of cavities defined by the first intermediate wall 810f. For example, as... Figure 19B As shown, the top wall 810b may define three cavities 806a to 806c, and the first intermediate wall 810f may also define three cavities 806d to 806f. In some embodiments, each of the plurality of cavities 806a to 806f may have the same dimensions (e.g., diameter) and can therefore be sized, sized, and configured to receive containers having the same dimensions (e.g., diameter, height, etc.). In other embodiments, at least one of the plurality of cavities 806a to 806f may have different dimensions, such as different diameters, than the remaining cavities 806a to 806f. Figure 19B As shown, for example, cavities 806a, 806b, 806d, and 806e can be sized and configured to receive containers of the same size, while cavities 806c and 806f can be sized and configured to receive containers of a different size than those contained in cavities 806a, 806b, 806d, and 806e. For example, cavities 806a, 806b, 806d, and 806e can have the same diameter and therefore can each be sized and configured to receive ISO 2R vials, while cavities 806c and 806f can have a larger diameter than cavities 806a, 806b, 806d, and 806e and therefore can be sized and configured to receive ISO 6R vials. In some embodiments, some of the cavities may have additional cutouts to allow the cavities to accommodate containers of various sizes. For example, as Figure 19B and Figure 21A As shown, cavities 806c and 806f may each have additional cutouts 806c' and 806f', respectively. Cutouts 806c' and 806f' allow cavities 806c and 806f to be flexible, enabling cavities 806c and 806f to be shaped, sized, and configured to accommodate containers of various sizes.

[0202] In some embodiments, when the insert 804 is in the assembled configuration, the positions of the cavities 806d, 806e, and 806f in the first intermediate wall 810f can be vertically aligned with the positions of the cavities 806a, 806b, and 806c in the top wall 810b, respectively. Therefore, when the container is disposed within the cavities 806a, 806b, and 806c, each container will be assembled through the cavities 806a, 806b, and 806c in the top wall 810b and the corresponding cavities 806d, 806e, and 806f in the first intermediate wall 810f. When the container is disposed within the cavities 806a, 806b, and 806c in the top wall 810b and the corresponding cavities 806d, 806e, and 806f in the first intermediate wall 810f, the bottom surface of at least one of the containers can abut against the second intermediate wall 810h. Therefore, the second intermediate wall 810h can be configured to abut the bottom surface of at least one of the containers and support the containers when the containers are received within the insert 804. Although Figure 19B Cavities 806a, 806b, 806d, and 806e are shown as circular cavities, but cavities 806a to 806f can be any of a variety of shapes, including semicircular, rectangular, triangular, quadrilateral, pentagonal, etc. In some embodiments, cavities 806a to 806f may all have the same shape. In other embodiments, cavities 806a to 806f may have different shapes.

[0203] In some embodiments, the insert 804 may further include a vertical rib support 821 extending between the second intermediate wall 810h and the second bottom wall 810d, such as Figure 21C As shown. The vertical rib support 821 can be integrally formed with the insert 804. The vertical rib support 821 can be configured to maintain a predefined distance between the second intermediate wall 810h and the second bottom wall 810d, such that the container received within the insert 804 is always raised from the second bottom wall 810d of the insert 804 and supported by at least one of the first intermediate wall 810f or the second intermediate wall 810h of the insert 804. Therefore, the vertical rib support 821 can ensure that the container received within the insert 804 is protected from bottom load impacts. In addition, the vertical rib support 821 can be configured to at least help the second intermediate wall 810h support the weight of the container.

[0204] In some embodiments, the second intermediate wall 810h may include a set of flaps 810p extending from the opposite side of the second intermediate wall 810h, such as Figure 19B As shown. Once the insert 804 is folded into the assembled configuration, the flap 810p can be folded upwards or downwards (as shown). Figure 21B and Figure 21C(As shown). When folded upwards or downwards, flap 810p can be configured to provide additional stiffness to insert 804, so that insert 804 can maintain its box shape when folded into its assembled configuration.

[0205] As discussed above, in some embodiments, the diameters of cavities 806a to 806e may be different to accommodate containers of different sizes within a single insert and a single package. For example, the diameters of cavities 806a, 806b, 806d, and 806e may be smaller than the diameter of cavity 806c, and therefore, the diameter of the first set of containers received within cavities 806a, 806b, 806d, and 806e may be smaller than the diameter of the second container received within cavity 806c. The first set of containers may, for example, be one of ISO 2R vials, ISO 6R vials, ISO 10R vials, ISO 20R vials, or ISO 50R vials, and the second container may be another of ISO 2R vials, ISO 6R vials, ISO 10R vials, ISO 20R vials, or ISO 50R vials. In one embodiment, for example, the first set of containers may be ISO 2R vials, and the second container may be ISO 6R vials. As discussed above, since the dimensions of the containers (e.g., diameter, height, etc.) may differ, the heights of the first intermediate wall 810f and the second intermediate wall 810h can be offset. For example, the first intermediate wall 810f can be positioned higher than the second intermediate wall 810h within the insert 804. Therefore, even if the height of the first set of containers received within cavities 806a, 806b, 806d, and 806e may be greater than the height of the second container received within cavity 806c, all containers can still be positioned at the same or similar heights within the insert 804 because the first intermediate wall 810f and the second intermediate wall 810h supporting the containers are offset.

[0206] In some embodiments, cavities 806a to 806e may each be sized and configured to receive the neck of a container received within insert 804. In other embodiments, cavities 806a to 806e may each be sized and configured to receive the body of a container received within insert 804. In yet another embodiment, some of cavities 806a to 806e may be sized and configured to receive the neck of a container, while others may be sized and configured to receive the body of a container. In some embodiments, the container received within insert 804 may include a vial filled or pre-filled with a drug. The drug may include, for example, talatumab (AMG757) or another product comprising a half-life-extended (HLE) anti-δ-like ligand 3 (DLL3) x anti-CD3 bispecific T-cell conjugate construct. In some embodiments, at least one of the containers received within the insert 804 may be a medicine bottle filled or prefilled with a drug different from the drugs contained in the other containers.

[0207] The systems disclosed herein for packaging one or more containers are not limited to the specific types or quantities of containers explicitly described herein. For example, packaging systems according to this disclosure may be designed and / or manufactured to accommodate any desired number of containers and any desired combination of containers, including standard glass vials, non-standard glass vials, and / or non-standard non-glass containers as specified in ISO 8362-1.

[0208] All features described herein (including in the specification, claims, abstract and drawings) and all steps in any method or process described herein may be combined in any combination except where one or more of the features and / or steps are mutually exclusive.

[0209] The above description describes various systems for packaging containers used in clinical, pharmaceutical, or medical applications. The systems described herein may include or be used with pharmaceuticals, including but not limited to those pharmaceuticals referred to below and their class and biosimilar counterparts. As used herein, the term pharmaceutical is used interchangeably with other similar terms and may refer to any type of pharmaceutical agent or therapeutic material, including traditional and non-traditional pharmaceuticals, nutritional supplements, tonics, biologics, bioactive agents and compositions, macromolecules, biosimilars, bioequivalents, therapeutic antibodies, peptides, proteins, small molecules, and class of substances. Non-therapeutic injectable materials are also included. Pharmaceuticals may be in liquid form, lyophilized form, or in a form that can be reconstituted from lyophilization. The following exemplary list of pharmaceuticals should not be considered as all-encompassing or restrictive.

[0210] In some embodiments, the container may be filled with a colony-stimulating factor, such as granulocyte colony-stimulating factor (G-CSF). Such G-CSF agents include, but are not limited to, Neulasta® (pefilgrastim, PEGylated filgrastim, PEGylated G-CSF, PEGylated hu-Met-G-CSF) and Neupogen® (filgrastim, G-CSF, hu-MetG-CSF), UDENYCA® (pefilgrastim-cbqv), Ziextenzo® (LA-EP2006; pefilgrastim-bmez) or FULPHILA (pefilgrastim-bmez).

[0211] In some embodiments, the container described herein may contain an erythropoiesis stimulating agent (ESA), which may be in liquid or lyophilized form. An ESA is any molecule that stimulates erythropoiesis. In some embodiments, an ESA is an erythropoiesis stimulating protein. As used herein, "erythropoiesis stimulating protein" means any protein that directly or indirectly causes activation of the erythropoietin receptor (e.g., by binding to and causing dimerization of the receptor). Erythropoiesis stimulating proteins include erythropoietin and its variants, analogs, or derivatives that bind to and activate the erythropoietin receptor; antibodies that bind to and activate the erythropoietin receptor; or peptides that bind to and activate the erythropoietin receptor. Erythropoietin-stimulating proteins include, but are not limited to, Epogen® (epogen α), Aranesp® (dabepoetin α), Dynepo® (epogen δ), Mircera® (methoxy-polyethylene glycol-epogen β), Hematide®, MRK-2578, INS-22, Retacrit® (epogen ζ), Neorecormon® (epogen β), Silapo® (epogen ζ), Binocrit® (epogen α), epogen α Hexal, Abseamed® (epogen α), Ratioepo® (epogen θ), Eporatio® (epogen θ), Biopoin® (epogen θ), epogen α, epogen β, epogen ι, epogen ω, epogen δ, epogen ζ, epogen θ and epogen δ, pegylated erythropoietin, carbamylated erythropoietin, and their molecules or variants or analogues.

[0212] The specific illustrative proteins are those described below, including their fusions, fragments, analogs, variants, or derivatives: OPGL-specific antibodies, peptides, related proteins, etc. (also known as RANKL-specific antibodies, peptides, etc.), including fully humanized OPGL-specific antibodies and human OPGL-specific antibodies, especially fully humanized monoclonal antibodies; myostatin-binding proteins, peptides, related proteins, etc., including myostatin-specific peptides; IL-4 receptor-specific antibodies, peptides, related proteins, etc., particularly those inhibiting the activity of IL-4 and / or IL-4 receptors. -13-mediated activities involving receptor binding; interleukin-1 receptor 1 ("IL1-R1") specific antibodies, peptides, and related proteins; Ang2 specific antibodies, peptides, and related proteins; NGF specific antibodies, peptides, and related proteins; CD22 specific antibodies, peptides, and related proteins, especially human CD22 specific antibodies, such as, but not limited to, humanized and fully human antibodies, including but not limited to humanized and fully human monoclonal antibodies, particularly including but not limited to human CD22 specific IgG antibodies, such as human-mouse monoclonal hLL2. Dimers of the γ-chain linked to the human-mouse monoclonal hLL2 κ chain by disulfide, such as the fully humanized human CD22-specific antibody in epazuzumab (CAS Registry No. 501423-23-0); IGF-1 receptor-specific antibodies, peptides, and related proteins, including but not limited to anti-IGF-1R antibodies; B-7-related protein 1-specific antibodies, peptides, and related proteins (“B7RP-1”, also known as B7H2, ICOSL, B7h, and CD275), including but not limited to B7RP-specific fully human monoclonal IgG2 antibodies, including but not limited to fully human IgG2 monoclonal antibodies binding to epitopes in the first immunoglobulin-like domain of B7RP-1, including but not limited to those inhibiting the interaction of B7RP-1 with its native receptor ICOS on activated T cells; IL-15-specific antibodies, peptides, and related proteins, such as, in particular, humanized monoclonal antibodies, including but not limited to HuMaxIL-15 antibodies and related proteins, such as 145c7; IFN. γ-specific antibodies, peptides, and related proteins, including but not limited to human IFN γ-specific antibodies, and including but not limited to fully human anti-IFN γ antibodies; TALL-1 specific antibodies, peptides, and related proteins, as well as other TALL-specific binding proteins; parathyroid hormone (“PTH”) specific antibodies, peptides, and related proteins; thrombopoietin receptor (“TPO-R”) specific antibodies, peptides, and related proteins;Hepatocyte growth factor (“HGF”) specific antibodies, peptides, and related proteins, including those targeting the HGF / SF:cMet axis (HGF / SF:c-Met), such as fully human monoclonal antibodies that neutralize hepatocyte growth factor / dispersant (HGF / SF); TRAIL-R2 specific antibodies, peptides, and related proteins; activin A specific antibodies, peptides, and proteins; TGF-β specific antibodies, peptides, and related proteins; amyloid-β protein specific antibodies, peptides, and related proteins; c-Kit specific antibodies, peptides, and related proteins, including but not limited to proteins that bind to c-Kit and / or other stem cell factor receptors; OX40L specific antibodies, peptides, and related proteins, including but not limited to those that bind to OX40L and / or OX40 receptors. Other ligand proteins; Activase® (alteplase, tPA); Aranesp® (dabepoetin α) erythropoietin [30-asparagine, 32-threonine, 87-valine, 88-asparagine, 90-threonine], dabepoetin α, novel erythropoiesis-stimulating protein (NESP); Epogen® (epogenetin α, or erythropoietin); GLP-1, Avonex® (interferon β-1a); Bexxar® (tosimomab, anti-CD22 monoclonal antibody); Betaseron® (interferon-β); Camppath® (alemumab, anti-CD52 monoclonal antibody); Dynepo® (epogenetin δ); Velcade® (bortezomib); MLN0002 (anti-α4β7) mAb); MLN1202 (anti-CCR2 chemokine receptor mAb); Enbrel® (etanercept, TNF receptor / Fc fusion protein, TNF blocker); Eprex® (ebertin α); Erbitux® (cetuximab, anti-EGFR / HER1 / c-ErbB-1); Genotropin® (growth hormone, human growth hormone); Herceptin® (trastuzumab, anti-HER2 / neu(erbB2) receptor mAb); Kanjinti™ (trastuzumab-anns), an anti-HER2 monoclonal antibody, a biosimilar of Herceptin®, or another product containing trastuzumab for the treatment of breast or gastric cancer; Humatrope® (growth hormone, human growth hormone); Humira® (adalimumab).Vectibix® (panitumumab), Xgeva® (dinosumab), Prolia® (dinosumab), RANK ligand immunoglobulin G2 human monoclonal antibody, Enbrel® (etanercept, TNF-receptor / Fc fusion protein, TNF blocker), Nplate® (romistamine), rilotumumab, ganitumab, conatumumab, brodalumab, insulin in solution; Infergen® (alfacon-1 interferon); Natrecor® (nesiritide; recombinant human B-type natriuretic peptide (hBNP)); Kineret® (anaspirin); Leukine® (saxaglastine, rhuGM-CSF); LymphoCide® (epazolizumab, anti-CD22 mAb); Benlysta™ (lymphostat B, belimumab, anti-BlyS) mAb); Metalyse® (tenectiplase, t-PA analog); Mircera® (methoxy-polyethylene glycol-ebertheline beta); Mylotarg® (gem-tuzumab-ozomicin); Raptiva® (efalizumab); Cimzia® (sertozumab, CDP 870); Soliris™ (eculizumab); Pexazumab (anti-C5 complement); Numax® (MEDI-524); Lucentis® (ranibumab); Panorex® (17-1A, ezolomide); Trabio® (lerdelimumab); TheraCim hR3 (Nimotuzumab); Omnitarg (Pertuzumab, 2C4); Osidem® (IDM-1); OvaRex® (B43.13); Nuvion® (Vencizumab); Cantuzumab Mertansine (huC242-DM1); NeoRecormon® (Ibertin β); Neumega® (Interleukin-11); Orthoclone OKT3® (Moromab-CD3, anti-CD3 monoclonal antibody); Procrit® (Ibertin α); Remicade® (Infliximab, anti-TNFα monoclonal antibody); Reopro® (Abciximab, anti-GP IIb / Ilia receptor monoclonal antibody); Actemra® (Anti-IL6 receptor mAb); Avastin® (Bevacizumab); HuMax-CD4 (Zanolimuab); Mvasi; TM(Bevacizumab - awwb); Rituxan® (rituximab, anti-CD20 mAb); Tarceva® (erlotinib); Roferon-A® (interferon alpha-2a); Simulect® (baliximab); Prexige® (romexicob); Synagis® (palizumab); 145c7-CHO (anti-IL15 antibody, see US Patent No. 7,153,507); Tysabri® (natelizumab, anti-alpha4 integrin mAb); Valortim® (MDX-1303, anti-anthrax protective antigen mAb); ABthrax™; Xolair® (omalizumab); ETI211 (anti-MRSA mAb); IL-1 trap (extracellular domain of the Fc portion of human IgG1 and IL-1 receptor components (type I receptor and receptor accessory proteins)); VEGF trap (with IgG1) Fc fusion of VEGFR1 Ig domain); Zenapax® (dalizumab); Zenapax® (dalizumab, anti-IL-2Rα mAb); Zevalin® (teimomab); Zetia® (ezetimibe); Orencia® (asceticipeptide, TACI-Ig); anti-CD80 monoclonal antibody (galiximab); anti-CD23 mAb (ruximab); BR2-Fc (huBR3 / huFc fusion protein, soluble BAFF antagonist); CNTO 148 (golimumab, anti-TNFα mAb); HGS-ETR1 (mapatumumab); human anti-TRAIL receptor-1 mAb); HuMax-CD20 (ocrelizumab, anti-CD20 human mAb); HuMax-EGFR (zalutumumab); M200 (volociximab, anti-α5β1 integrin mAb); MDX-010 (ipramab, anti-CTLA-4 mAb and VEGFR-1 (IMC-18F1); anti-BR3 mAb; anti-clostridium difficile toxin A and toxin BC mAb MDX-066 (CDA-1 and MDX-1388); anti-CD22 dsFv-PE38 conjugates (CAT-3888 and CAT-8015); anti-CD25 mAb (HuMax-TAC); anti-CD3 mAb (NI-0401); adecatumumab; anti-CD30 mAb (MDX-060); MDX-1333 (anti-IFNAR); anti-CD38 mAb (HuMax CD38); anti-CD40L mAb; anti-Cripto mAb;Anti-CTGF fibrinogen for stage I idiopathic pulmonary fibrosis (FG-3019); Anti-CTLA4 mAb; Anti-eosinophil chemokine 1 mAb (CAT-213); Anti-FGF8 mAb; Anti-ganglioside GD2 mAb; Anti-ganglioside GM2 mAb; Anti-GDF-8 human mAb (MYO-029); Anti-GM-CSF receptor mAb (CAM-3001); Anti-HepC mAb (HuMax HepC); Anti-IFNα mAb (MEDI-545, MDX-198); Anti-IGF1R mAb; Anti-IGF-1R mAb (HuMax-Inflam); Anti-IL12 mAb (ABT-874); Anti-IL12 / IL23 mAb (CNTO 1275); Anti-IL13 mAb (CAT-354); Anti-IL2Ra mAb (HuMax-TAC); anti-IL5 receptor mAb; anti-integrin receptor mAb (MDX-018, CNTO 95); anti-IP10 ulcerative colitis mAb (MDX-1100); BMS-66513; anti-mannose receptor / hCGβ mAb (MDX-1307); anti-mesothelin dsFv-PE38 conjugate (CAT-5001); anti-PD1 mAb (MDX-1106 (ONO-4538)); anti-PDGFRα antibody (IMC-3G3); anti-TGFβ mAb (GC-1008); anti-TRAIL receptor-2 human mAb (HGS-ETR2); anti-TWEAK mAb; anti-VEGFR / Flt-1 mAb; and anti-ZP3 mAb (HuMax-ZP3).

[0213] In some embodiments, the container described herein may contain a sclerosing protein antibody for the treatment of osteoporosis and / or fracture healing in postmenopausal women, such as, but not limited to, romosozumab, blosozumab, BPS 804 (Novartis), Evenity™ (romosozumab-aqqg), another product containing romosozumab, and in other embodiments, a monoclonal antibody (IgG) that binds to the human proprotein convertase subtilisin / Kexin type 9 (PCSK9). Such PCSK9-specific antibodies include, but are not limited to, Repatha® (evolocumab) and Praluent® (alirocumab). In other embodiments, the container may contain rituximab, bixalomer, trebananib, ganitamumab, kanamumab, motesanib diphosphate, brodatumab, vidupiprant, or panitumumab. In some embodiments, the container may be filled with IMLYGIC® (talimogene laherparepvec) or another oncolytic HSV for the treatment of melanoma or other cancers, including but not limited to OncoVEX GALV / CD; OrienX010; G207; 1716; NV1020; NV12023; NV1034; and NV1042. In some embodiments, the container may contain an endogenous tissue metalloproteinase inhibitor (TIMP), such as, but not limited to, TIMP-3. In some embodiments, the container may contain Aimovig® (erenumab-aooe), anti-human CGRP-R (calcitonin gene-related peptide type 1 receptor), or another product containing erenumab for the treatment of migraines. Antagonistic antibodies against the human calcitonin gene-related peptide (CGRP) receptor (such as, but not limited to, erenumab) and bispecific antibody molecules targeting the CGRP receptor and other headache targets may also be included in the container of this disclosure. Furthermore, bispecific T-cell binding agents (BiTE®) molecules, such as, but not limited to, BLINCYTO® (blinatumomab), may also be included in the container of this disclosure. In some embodiments, the container may contain an APJ macromolecular agonist, such as, but not limited to, apelin or an analogue thereof. In some embodiments, a therapeutically effective amount of anti-thymic stromal lymphopoietin (TSLP) or TSLP receptor antibody is used in the container of this disclosure.In some embodiments, the container may contain Avsola for treating autoimmune diseases. TM (infliximab-axxq), an anti-TNF α monoclonal antibody, a biosimilar of Remicade® (infliximab) (Janssen Biotech, Inc.) or another product containing infliximab. In some embodiments, the container may contain Kyprolis® (carfilzomib) for the treatment of multiple myeloma, (2S)-N-((S)-1-((S)-4-methyl-1-((R)-2-methylethyleneoxy-2-yl)-1-oxopentane-2-ylcarbamoyl)-2-phenylethyl)-2-((S)-2-(2-morpholinoacetamyl)-4-phenylbutamido)-4-methylpentanamide, or another product containing carfilzomib. In some embodiments, the container may contain Otezla® (apremilast), N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methanesulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide, or another product containing apremilast for the treatment of various inflammatory conditions. In some embodiments, the container may contain Parsabiv TM(Villacartide HCl, KAI-4169) or another product containing vilalacartide HCl for the treatment of secondary hyperparathyroidism (sHPT), such as hemodialysis in patients with chronic kidney disease (KD). In some embodiments, the container may contain ABP 798 (rituximab), a biosimilar candidate of Rituxan® / MabThera™, or another product containing an anti-CD20 monoclonal antibody. In some embodiments, the container may contain a VEGF antagonist (e.g., a non-antibody VEGF antagonist) and / or a VEGF-Trap (e.g., aflibercept (a fusion of the Fc domain of IgG1 with the Ig domain 2 of VEGFR1 and the Ig domain 3 of VEGFR2)). In some embodiments, the container may contain ABP959 (eculimab), a biosimilar candidate of Soliris®, or another product containing a monoclonal antibody that specifically binds to complement protein C5. In some embodiments, the container may contain Rozibafusp alfa (formerly AMG 570), a novel bispecific antibody-peptide conjugate that simultaneously blocks the activities of ICOSL and BAFF. In some embodiments, the container may contain omegacarb (a small molecule selective cardiac myosin activator), or myotrope which directly targets the cardiac contraction mechanism, or another product containing a small molecule selective cardiac myosin activator. In some embodiments, the container may contain sotorazib (formerly AMG 510), KRAS G12C Small molecule inhibitors or those containing KRAS G12CAnother product containing a small molecule inhibitor. In some embodiments, the container may contain tezepelumab, a human monoclonal antibody that inhibits the action of thymic stromal lymphopoietin (TSLP), or another product containing a human monoclonal antibody that inhibits the action of TSLP. In some embodiments, the drug delivery device may contain or be used with nocatinlimab (AMG 451), a human anti-OX40 monoclonal antibody that expresses and blocks OX40 on activated T cells to inhibit and / or reduce the number of OX40-pathogenic T cells responsible for driving systemic and local atopic dermatitis inflammatory responses. In some embodiments, the container may contain AMG 714, a human monoclonal antibody that binds to interleukin-15 (IL-15), or another product containing a human monoclonal antibody that binds to interleukin-15 (IL-15). In some embodiments, the container may contain AMG 890, a small interfering RNA (siRNA) that lowers lipoprotein(a) (also known as Lp(a)), or another product containing a small interfering RNA (siRNA) that lowers lipoprotein(a). In some embodiments, the container may contain ABP 654 (human IgG1κ antibody), a biosimilar candidate of Stelara®, or another product containing a human IgG1κ antibody and / or binding to the p40 subunit of the human cytokines interleukin (IL)-12 and IL-23. In some embodiments, the container may contain Amjevita. TM Or Amgevita TM(Formerly named ABP 501) (monoclonal antibody against TNF human IgG1), a biosimilar candidate of Humira®, or another product containing a human monoclonal antibody against TNF human IgG1. In some embodiments, the container may contain AMG 160, or another product containing a half-life-extended (HLE) anti-prostate-specific membrane antigen (PSMA) x anti-CD3 BiTE® (bispecific T-cell conjugate) construct. In some embodiments, the container may contain AMG 119, or another product containing delta-like ligand 3 (DLL3) CAR T (chimeric antigen receptor T-cell) cell therapy. In some embodiments, the container may contain AMG 119, or another product containing delta-like ligand 3 (DLL3) CAR T (chimeric antigen receptor T-cell) cell therapy. In some embodiments, the container may contain AMG 133, or another product containing a gastric inhibitory peptide receptor (GIPR) antagonist and a GLP-1R agonist. In some embodiments, the container may contain AMG171, or another product containing a growth differentiation factor 15 (GDF15) analog. In some embodiments, the container may contain AMG 176, or another product containing a small molecule inhibitor of myeloid leukemia 1 (MCL-1). In some embodiments, the container may contain AMG 199, or another product containing a bispecific T-cell conjugate with extended half-life (HLE) (BiTE®). In some embodiments, the container may contain AMG 256 or another product (containing anti-PD-1 xIL21 mutant protein and / or IL-21 receptor agonist) designed to selectively activate the interleukin 21 (IL-21) pathway in programmed cell death-1 (PD-1) positive cells. In some embodiments, the container may contain AMG 330, or another product containing an anti-CD33 x anti-CD3 BiTE® (bispecific T-cell conjugate) construct. In some embodiments, the container may contain AMG 404 or another product (containing a human anti-programmed cell death-1 (PD-1) monoclonal antibody) being investigated for the treatment of patients with solid tumors. In some embodiments, the container may contain AMG 427, or another product containing an extended half-life (HLE) anti-fms-like tyrosine kinase 3 (FLT3) x anti-CD3 BiTE® (bispecific T-cell conjugate) construct. In some embodiments, the container may contain AMG 430, or another product containing an anti-Jagged-1 monoclonal antibody. In some embodiments, the container may contain AMG 506, which is being investigated for solid tumor treatment, or another product (containing a multispecific FAP x 4-1BB-targeting DARPin® biologic). In some embodiments, the container may contain AMG509, or another product containing a bivalent T-cell conjugate, and is designed using XmAb® 2+1 technology.In some embodiments, the container may contain AMG 562, or another product containing an extended-life (HLE) CD19 x CD3 BiTE® (bispecific T-cell conjugate) construct. In some embodiments, the container may contain Efavaleukin α (formerly AMG592), or another product containing an IL-2 mutant protein Fc fusion protein. In some embodiments, the container may contain AMG596, or another product containing a CD3 x epidermal growth factor receptor vIII (EGFRvIII) BiTE® (bispecific T-cell conjugate) molecule. In some embodiments, the container may contain AMG 673, or another product containing an extended-life (HLE) anti-CD33 x anti-CD3 BiTE® (bispecific T-cell conjugate) construct. In some embodiments, the container may contain AMG 701, or another product containing an extended-life (HLE) anti-B-cell maturation antigen (BCMA) x anti-CD3 BiTE® (bispecific T-cell conjugate) construct. In some embodiments, the container may contain talatumab (AMG757), or another product containing an extended-life (HLE) anti-δ-like ligand 3 (DLL3) x anti-CD3 BiTE® (bispecific T-cell conjugate) construct. In some embodiments, the container may contain AMG 910, or another product containing an extended-life (HLE) claudin 18.2 x CD3 BiTE® (bispecific T-cell conjugate) construct.

[0214] Although systems for packaging one or more containers (such as glass vials) have been described with reference to exemplary embodiments, they are not limited thereto. This detailed description is to be interpreted as exemplary only and does not describe every possible embodiment of this disclosure. Many alternative embodiments can be implemented using current technology or technology developed after the date of this patent application, which still fall within the scope of the claims defining the invention disclosed herein.

[0215] Those skilled in the art will understand that various modifications, alterations, and combinations can be made to the embodiments described above without departing from the spirit and scope of the invention disclosed herein, and such modifications, alterations, and combinations can be considered to be within the scope of the inventive concept.

Claims

1. A system for packaging one or more containers, comprising: A paper box having a storage configuration and an assembly configuration, wherein the paper box is substantially flat in the storage configuration, and the paper box includes: The bottom box, when the cardboard box is in the assembled configuration, has a first bottom wall, a first side wall, a second side wall, a first rear wall, and a first front wall; The lid is attached to the bottom housing and is movable between an open position and a closed position; A first flap, extending from a first side wall of the bottom box; and A second flap extends from a second sidewall of the bottom housing, the second sidewall being opposite to and facing the first sidewall, wherein the first flap and the second flap define a set of cavities; and An insert is configured to be disposed within the bottom housing of the cardboard box. The insert has a storage configuration and an assembly configuration. In the storage configuration, the insert is substantially flat, and wherein the insert defines at least one cavity sized to receive at least one container. In this assembly configuration, the insert includes a top wall defining the at least one cavity, a second bottom wall, a second rear wall, a second front wall, and an intermediate wall positioned between the top wall and the second bottom wall.

2. The system as claimed in claim 1, wherein, The insert defines a first cavity, which is sized to receive a first container; And a second cavity, which is sized to receive a second container.

3. The system as described in claim 2, wherein, The diameter of the first cavity is smaller than the diameter of the second cavity, and the diameter of the first container is smaller than the diameter of the second container.

4. The system as claimed in claim 1, wherein, When the at least one container is received in the at least one cavity, the bottom surface of the at least one container is configured to abut the intermediate wall of the insert.

5. The system as claimed in claim 1, wherein, The carton further includes a release tab, which is a portion of at least one of the lid and the bottom box body, and is defined by a perforated line in at least one of the lid and the bottom box body.

6. The system of claim 5, wherein: When the cover is in the closed position, the release tab is secured to at least one of the cover and the bottom housing via the perforation, and When the cover is in the open position, the release tab separates from at least one of the cover and the bottom housing along the perforation line.

7. The system of claim 5, wherein, The release tab is a push tab that removes the release tab from at least one of the cover and the bottom housing.

8. The system of claim 5, further comprising an adhesive positioned on at least a portion of the release tab, and wherein, The release tab includes a slit-shaped cut to improve the fixation between the release tab and the adhesive.

9. The system as claimed in claim 1, wherein, When the insert is disposed in the bottom box of the cardboard box, the second bottom wall is configured to be adjacent to the first bottom wall, the second rear wall is configured to be adjacent to the first rear wall, and the second front wall is configured to be adjacent to the first front wall.

10. The system of claim 1, wherein, The at least one container includes a medicine bottle.

11. The system of claim 10, wherein, The vial is one of the following: ISO 2R vial, ISO 6R vial, ISO 10R vial, ISO 20R vial, or ISO 50R vial.

12. The system of claim 2, wherein: The first container is one of the following: ISO 2R vials, ISO 6R vials, ISO 10R vials, ISO 20R vials, or ISO 50R vials, and The second container is one of the following: ISO 2R vial, ISO 6R vial, ISO 10R vial, ISO 20R vial, or ISO 50R vial.

13. The system of claim 10, wherein, The vial is filled or pre-filled with a drug, including talatumab.

14. The system of claim 1, wherein, The box and insert are made of cardboard or a combination of synthetic and natural materials.

15. A system for packaging multiple containers, comprising: A paper box having a storage configuration and an assembly configuration, wherein the paper box is substantially flat in the storage configuration, and the paper box includes: The bottom box, when the cardboard box is in the assembled configuration, has a first bottom wall, a first side wall, a second side wall, a first rear wall, and a first front wall; The lid is attached to the bottom housing and is movable between an open position and a closed position; A tray, which is attached to the bottom housing and is movable between a first position and a second position; A first flap, extending from a first side wall of the bottom box; and A second flap extends from a second sidewall of the bottom box body, the second sidewall being opposite to and facing the first sidewall; and An insert, configured to be disposed within the bottom housing of the cardboard box, has a storage configuration and an assembly configuration. In the storage configuration, the insert is substantially flat, and wherein the insert defines a plurality of cavities, each sized to receive a corresponding one of a plurality of containers. In this assembly configuration, the insert includes a top wall, a second bottom wall, a third side wall, a fourth side wall, a second rear wall, a second front wall, and a first intermediate wall positioned between the top wall and the second bottom wall. The top wall and the first intermediate wall define the plurality of cavities.

16. The system of claim 15, wherein, The tray is configured to define a second bottom box within the bottom box when the tray is in the second position.

17. The system of claim 15, wherein, The insert further includes a first pair of opposing flaps connected to the second front wall and a second pair of opposing flaps connected to the second rear wall.

18. The system of claim 15, wherein, The insert further includes a third pair of opposing flaps coupled to the top wall, wherein the third pair of opposing flaps is movable between an open position and a closed position.

19. The system of claim 18, wherein, In the closed position, the third pair of opposing flaps defines the third and fourth sidewalls of the insert.

20. The system of claim 15, wherein, When the insert is disposed in the bottom box of the cardboard box, the second bottom wall is configured to be adjacent to the first bottom wall, the third side wall is configured to be adjacent to the first side wall, the fourth side wall is configured to be adjacent to the second side wall, the second rear wall is configured to be adjacent to the first rear wall, and the second front wall is configured to be adjacent to the first front wall.

21. The system of claim 15, wherein, The insert further includes a second intermediate wall positioned between the first intermediate wall and the second bottom wall.

22. The system of claim 21, wherein, When the plurality of containers are received in the plurality of cavities, at least one of the first intermediate wall or the second intermediate wall is configured to adjoin the bottom surface of the plurality of containers.

23. The system of claim 15, wherein, The insert further includes a vertical rib support extending between the second intermediate wall and the second bottom wall, wherein the vertical rib support is configured to maintain a predefined distance between the second intermediate wall and the second bottom wall.

24. The system of claim 15, wherein, The number of cavities defined by the top wall is different from the number of cavities defined by the first intermediate wall.

25. The system of claim 15, wherein, The number of cavities defined by the top wall is equal to the number of cavities defined by the first intermediate wall.

26. The system of claim 15, wherein, Each of the multiple cavities has the same size.

27. The system of claim 15, wherein, At least one of the cavities has a different size than the other cavities.

28. The system of claim 15, wherein, The carton further includes a release tab, which is a portion of at least one of the lid and the bottom box body, and is defined by a perforated line in at least one of the lid and the bottom box body.

29. The system of claim 28, wherein: When the cover is in the closed position, the release tab is secured to at least one of the cover and the bottom housing via the perforation, and When the cover is in the open position, the release tab separates from at least one of the cover and the bottom housing along the perforation line.

30. The system of claim 28, wherein, The release tab is a push tab that removes the release tab from at least one of the cover and the bottom housing.

31. The system of claim 28, further comprising an adhesive positioned on at least a portion of the release tab, and wherein, The release tab includes a slit-shaped cut to improve the fixation between the release tab and the adhesive.

32. The system of claim 15, wherein, At least one of the multiple containers includes a medicine bottle.

33. The system of claim 32, wherein, The vial is one of the following: ISO 2R vial, ISO 6R vial, ISO 10R vial, ISO 20R vial, or ISO 50R vial.

34. The system of claim 15, wherein: The multiple containers include at least a first medicine bottle and a second medicine bottle. The first vial is one of the following: ISO 2R vial, ISO 6R vial, ISO 10R vial, ISO 20R vial, or ISO 50R vial, and The second vial is one of the following: ISO 2R vial, ISO 6R vial, ISO 10R vial, ISO 20R vial, or ISO 50R vial.

35. The system of claim 32, wherein, The vial is filled or pre-filled with a drug, including talatumab.

36. The system of claim 15, wherein, The box and insert are made of cardboard or a combination of synthetic and natural materials.

37. A system for packaging one or more containers, comprising: A paper box having a storage configuration and an assembly configuration, wherein the paper box is substantially flat in the storage configuration, and the paper box includes: Multiple sidewalls; Top wall; bottom wall; A first fold, the first fold extending from a first sidewall of the plurality of sidewalls; and A second fold extends from a second sidewall among the plurality of sidewalls, the second sidewall being opposite to and facing the first sidewall. The first fold and the second fold define the first set of cavities; and An insert, configured to be disposed within the cardboard box, has a storage configuration and an assembly configuration, in which the insert is substantially flat. In this assembly configuration, the insert includes a first layer, a second layer positioned at a first distance below the first layer, and a third layer positioned at a second distance below the second layer. The first layer includes at least one hole configured to receive a container and a first set of flaps extending from the opposite side of the first layer. The second layer is configured to support the bottom surface of the container and includes a second set of flaps extending from the opposite side of the second layer. The first set of flaps in the first layer and the second set of flaps in the second layer are configured to fold downwards.

38. The system of claim 37, wherein, In this assembly configuration, the carton includes four side walls, the top wall, and the bottom wall, and wherein at least the four side walls and the bottom wall define a second cavity inside the carton.

39. The system of claim 38, wherein, The second cavity inside the cardboard box is configured to accommodate the insert.

40. The system of claim 39, wherein, In this assembly configuration, the insert includes two opposing sidewalls connecting the first layer, the second layer, and the third layer.

41. The system of claim 40, wherein, When the insert is in the assembled configuration, the first set of flaps of the first layer and the second set of flaps of the second layer are configured to fold downward to define the two additional sidewalls of the insert.

42. The system of claim 41, wherein, When the insert is in this assembly configuration and positioned within the cardboard box: The inner surface of the first set of flaps in the first layer is configured to be adjacent to the outer surface of the second set of flaps in the second layer, and The outer surface of the first set of flaps in the first layer is configured to be adjacent to the inner surface of two of the four side walls of the cardboard box.

43. The system of claim 37, wherein, The first set of cavities includes a generally rectangular air cavity, and wherein the first set of cavities is configured to provide a distance between the top wall of the carton and the top surface of the container to protect the container from top loads.

44. The system of claim 37, wherein, In this assembly configuration, the insert includes two opposing sidewalls connecting the first layer, the second layer, and the third layer, and wherein, in this assembly configuration, a first set of flaps of the first layer and a second set of flaps of the second layer are configured to fold downward to define two additional sidewalls of the insert.

45. The system of claim 44, wherein, The insert comprises a first layer, a second layer, a third layer, two opposing sidewalls connecting the first layer, the second layer, and the third layer, and two additional sidewalls integrally formed.

46. ​​The system of claim 37, wherein, When the insert is placed inside the cardboard box, the second layer of the insert is raised by the second distance from the third layer of the insert, such that the bottom surface of the container is raised by the second distance from the bottom wall of the cardboard box.

47. The system of claim 37, wherein, The box has multiple side walls, top wall, bottom wall, first fold, and second fold formed as a single unit.

48. The system of claim 37, wherein, The container is a vial, and the vial is one of the following: ISO 2R vial, ISO 6R vial, ISO 10R vial, ISO 20R vial, or ISO 50R vial.

49. A system for packaging multiple containers, comprising: A paper box having a storage configuration and an assembly configuration, wherein the paper box is substantially flat in the storage configuration, and the paper box includes: Multiple sidewalls; Top wall; bottom wall; A first fold, the first fold extending from a first sidewall of the plurality of sidewalls; and A second fold extends from a second sidewall among the plurality of sidewalls, the second sidewall being opposite to and facing the first sidewall. The first fold and the second fold define the first set of cavities; and An insert, configured to be disposed within the cardboard box, has a storage configuration and an assembly configuration, in which the insert is substantially flat. In this assembly configuration, the insert includes a first layer, a second layer positioned at a first distance below the first layer, a third layer positioned at a second distance below the second layer, and a fourth layer positioned at a third distance below the third layer. The first layer includes a first set of holes configured to receive a plurality of containers, wherein each hole in the first set of holes is configured to receive a first portion of a corresponding container among the plurality of containers, and wherein the first layer includes a first set of flaps extending from the opposite side of the first layer. The second layer includes a second set of holes configured to receive the plurality of containers, wherein each hole in the second set of holes is configured to receive a second portion of a corresponding container among the plurality of containers, and wherein the second layer includes a second set of flaps extending from the opposite side of the second layer. The third layer is configured to support the bottom surface of the plurality of containers, and The first set of flaps in the first layer and the second set of flaps in the second layer are configured to fold downwards.

50. The system of claim 49, wherein, The insert further includes a vertical rib support extending between the third layer and the fourth layer, wherein the vertical rib support is configured to maintain a third distance between the third layer and the fourth layer.

51. The system of claim 49, wherein, The first set of holes in the first layer and the second set of holes in the second layer are vertically aligned.

52. The system of claim 49, wherein, In this assembly configuration, the carton includes four side walls, the top wall, and the bottom wall, and wherein at least the four side walls and the bottom wall define a second cavity inside the carton.

53. The system of claim 52, wherein, The second cavity inside the cardboard box is configured to accommodate the insert.

54. The system of claim 53, wherein, In this assembly configuration, the insert includes two opposing sidewalls connecting the first layer, the second layer, the third layer, and the fourth layer.

55. The system of claim 54, wherein, When the insert is in the assembled configuration, the first set of flaps of the first layer and the second set of flaps of the second layer are configured to fold downward to define the two additional sidewalls of the insert.

56. The system of claim 55, wherein, When the insert is in this assembly configuration and positioned within the cardboard box: The inner surface of the first set of flaps in the first layer is configured to be adjacent to the outer surface of the second set of flaps in the second layer, and The outer surface of the first set of flaps in the first layer is configured to be adjacent to the inner surface of two of the four side walls of the cardboard box.

57. The system of claim 49, wherein, The first set of cavities includes a generally rectangular air cavity, and wherein the first set of cavities is configured to provide a distance between the top wall of the carton and the top surface of the plurality of containers to protect the plurality of containers from top loads.

58. The system of claim 49, wherein, In this assembly configuration, the insert includes two opposing sidewalls connecting the first layer, the second layer, the third layer, and the fourth layer, and wherein, in this assembly configuration, a first set of flaps of the first layer and a second set of flaps of the second layer are configured to fold downward to define two additional sidewalls of the insert.

59. The system of claim 58, wherein, The insert comprises a first layer, a second layer, a third layer, a fourth layer, two opposing sidewalls connecting the first layer, the second layer, the third layer, and the fourth layer, and two additional sidewalls integrally formed.

60. The system of claim 49, wherein, When the insert is placed inside the cardboard box, the third layer of the insert is raised by the third distance from the fourth layer of the insert, such that the bottom surface of the plurality of containers is raised by the third distance from the bottom wall of the cardboard box.

61. The system of claim 49, wherein, The box has multiple side walls, top wall, bottom wall, first fold, and second fold formed as a single unit.

62. The system of claim 49, wherein, The plurality of containers are vials, and wherein the vials include at least one of the following: ISO 2R vials, ISO 6R vials, ISO 10R vials, ISO 20R vials, or ISO 50R vials.

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