A reaction kettle for producing a pharmaceutical intermediate amine compound

Abstract

The application discloses a kind of medical intermediate aminide production reaction kettle, belong to medical intermediate synthesis reaction equipment technical field, including kettle body, shell, liquid nitrogen conversion box, low-temperature liquid storage tank and drying cabinet, the liquid nitrogen conversion box, low-temperature liquid storage tank and drying cabinet are sequentially arranged between kettle body and shell, the drying cabinet is filled with zeolite molecular sieve inside;Nitrogen injection hole height can be adjusted by liftable mounting block cooperation with limiting rod, can be switched to align upper nitrogen inlet pipe or lower nitrogen inlet pipe, realize dry high-purity nitrogen into layer, oxygen density is greater than nitrogen, nitrogen is passed to upper inlet pipe, oxygen in the kettle bottom layer can be completely replaced from oxygen outlet to waste gas collection tank;If nitrogen absorption reaction water vapor in the kettle becomes wet nitrogen, density decreases, dry high-purity nitrogen is passed to lower inlet pipe, wet nitrogen containing water in upper layer is recycled from wet nitrogen outlet to nitrogen tank for regeneration, oxygen, trace water vapor in the kettle are completely eliminated, to avoid medical intermediate aminide oxidation, hydrolysis deterioration.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical intermediate synthesis reaction equipment technology, specifically a pharmaceutical intermediate amine production reactor. Background Technology

[0002] Amines are core pharmaceutical intermediates in the synthesis of antibiotics and quinolone targeted drugs. Cyclopropyl ethyl ester amine, a key raw material for the preparation of ciprofloxacin hydrochloride, contains highly reactive amino groups in its molecular structure, making it highly susceptible to oxidation and hydrolysis side reactions throughout the synthesis process. Furthermore, the amination reaction is strongly exothermic, requiring stringent conditions for an oxygen- and anhydrous closed environment, precise feed addition, and stable low-temperature control. The amino group readily undergoes free radical oxidation coupling reactions with trace amounts of oxygen in the air, generating structurally similar and difficult-to-separate aromatic amine dimer impurities. Even ppm-level water vapor within the system can attack acyl and fluorine substitution sites, hydrolyzing to generate phenolic byproducts. Both of these significantly reduce the yield of the final product, and the impurities are difficult to remove by recrystallization, failing to meet GMP purity control standards for pharmaceutical intermediates.

[0003] Chinese patent CN117983168A discloses a reactor for the production of cyclopropyl ethyl ester amines with intelligent feeding control. This device solves the problem that current production processes of cyclopropyl ethyl ester amines cannot intelligently and accurately input raw materials, resulting in poor quality or defective products. However, it still suffers from common industry pain points. Traditional reactors lack an automatic nitrogen injection adjustment mechanism that allows switching between upper and lower gas inlets, making it impossible to flexibly replace gas according to the gas composition within the system and achieve a completely oxygen-free and water-free sealed protection throughout the process. At the same time, they lack a matching low-temperature circulating temperature control structure, and the exothermic synthesis of amines can easily trigger high-temperature side reactions, making it difficult to guarantee product purity.

[0004] Therefore, the present invention provides a pharmaceutical intermediate amine production reactor with oxygen-free and water-free protection, which solves the defects of existing equipment such as inability to perform stratified gas replacement, incomplete dehumidification and deoxygenation, poor temperature control leading to amine deterioration and low yield. Summary of the Invention

[0005] The purpose of this invention is to provide a reaction vessel for producing pharmaceutical intermediate amine compounds, in order to solve the problems mentioned in the background art.

[0006] By adopting the above technical solutions, continuous production of pharmaceutical intermediates has been achieved.

[0007] A reaction vessel for producing a pharmaceutical intermediate amine compound includes a vessel body, a shell, a liquid nitrogen conversion tank, a cryogenic storage tank, and a drying chamber. The liquid nitrogen conversion tank, the cryogenic storage tank, and the drying chamber are sequentially arranged between the vessel body and the shell. The drying chamber is filled with zeolite molecular sieves. A cavity is formed in the wall of the vessel body, and a spiral tube is installed in the cavity. One end of the spiral tube is sealed to the cryogenic storage tank. A nitrogen tank and a waste gas collection tank are provided on the side of the liquid nitrogen conversion tank away from the cryogenic storage tank. A pipe is sealed between the nitrogen tank and the liquid nitrogen conversion tank. The other end of the spiral tube is sealed to the nitrogen tank. The upper half of the vessel body has a nitrogen vent and an upper nitrogen inlet pipe sealed on its outer wall, and the lower half of the vessel body has an oxygen outlet and a lower nitrogen inlet pipe sealed on its outer wall. An installation block is provided between the vessel body and the shell, and a nitrogen injection hole is provided on the installation block. An adjustment mechanism is provided on both sides of the installation block. The adjustment mechanism includes an installation cylinder, a connecting rod, a circular plate, a fifth spring, and multiple limiting rods. The connecting rod is fixedly connected to the circular plate, and the fifth spring is sleeved on the connecting rod. Multiple mounting platforms are fixedly connected to the top of the circular plate, and the limiting rods are rotatably connected to the mounting platforms.

[0008] Compared with the prior art, the beneficial effects of the present invention are: the reaction vessel for producing the pharmaceutical intermediate amine compound, The height of the nitrogen injection hole can be adjusted by using a liftable mounting block and a limiting rod to switch between aligning with the upper or lower nitrogen inlet pipe, achieving stratified introduction of dry, high-purity nitrogen: when oxygen is denser than nitrogen, nitrogen is introduced into the upper inlet pipe, completely replacing the oxygen at the bottom of the reactor with oxygen from the oxygen outlet to the waste gas collection box; if the nitrogen in the reactor absorbs water vapor from the reaction and becomes wet nitrogen, reducing its density, dry, high-purity nitrogen is introduced into the lower inlet pipe, recovering the upper layer of water-containing wet nitrogen from the wet nitrogen outlet to the nitrogen tank for regeneration, completely eliminating oxygen and trace amounts of water vapor in the reactor, preventing oxidation and hydrolysis of pharmaceutical intermediate amines, and significantly improving product purity and yield.

[0009] By setting a connecting rod and a second spring, the cover is pressed tightly against the openings of the upper and lower nitrogen inlet pipes. During the movement of the mounting block, the drive block squeezes the guide block to automatically open the cover, completing the nitrogen replacement. After the mounting block is removed, the spring automatically resets, and the cover presses tightly to seal the gas inlet pipe. No manual opening or closing is required, ensuring a completely sealed, water-free, and oxygen-free environment for the entire process of amine synthesis, with a high degree of automation.

[0010] Liquid nitrogen is transported to the spiral heat exchange tube on the reactor wall via a liquid nitrogen conversion tank and a cryogenic storage tank. The vaporization and heat absorption stabilize the reaction temperature inside the reactor, suppressing high-temperature side reactions in the amine synthesis process. After heat exchange, the nitrogen is returned to the nitrogen tank for recycling. Combined with zeolite molecular sieve for deep drying of nitrogen, it has the triple functions of temperature control, anhydrous and oxygen-free protection, and gas recycling, making it suitable for continuous production of pharmaceutical intermediates. Attached Figure Description

[0011] Figure 1 This is a schematic diagram of the structure of the reaction vessel of the present invention; Figure 2 This is a rear cross-sectional view of the reaction vessel of the present invention; Figure 3 This is a front cross-sectional view of the reactor of the present invention; Figure 4 For the present invention Figure 3 Enlarged view of point A in the middle; Figure 5 For the present invention Figure 3 Enlarged view of point B in the middle; Figure 6 For the present invention Figure 3 Enlarged view of point C in the middle; Figure 7 This is a cross-sectional view of the casing of the present invention; Figure 8 For the present invention Figure 7 Enlarged view at point E in the middle; Figure 9 This is a cross-sectional view of the mounting cylinder of the present invention; Figure 10 For the present invention Figure 9 Enlarged view of point F in the middle.

[0012] In the diagram: 1. Reactor body; 2. Shell; 3. Nitrogen tank; 4. Waste gas collection tank; 5. Cover plate; 6. Liquid nitrogen conversion tank; 7. Low temperature storage tank; 8. Drying oven; 9. Zeolite molecular sieve; 10. Nitrogen discharge port; 11. Oxygen outlet; 12. Spiral tube; 13. Mounting plate; 14. Flexible hose; 15. Lower nitrogen inlet pipe; 16. Plug; 17. First spring; 18. Upper nitrogen inlet pipe; 19. Cover; 20. Connecting rod; 21. Mounting rod; 22. Round rod; 23. Slider; 24. Second spring; 25. Mounting post; 26. Third spring; 27. Mounting block; 28. Drive block; 29. ​​Mounting cylinder; 30. Connecting rod; 31. Cylinder; 32. Fourth spring; 33. First connecting platform; 34. Second connecting platform; 35. Guide block; 36. Mounting cavity; 37. Mounting hole; 38. Circular plate; 39. Fifth spring; 40. Mounting platform; 41. Limiting rod; 42. Movable groove; 43. Movable block. Detailed Implementation

[0013] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0014] Please see Figure 1-10This invention provides a technical solution: a pharmaceutical intermediate amine production reactor, comprising a reactor body 1, a shell 2, a liquid nitrogen conversion tank 6, a cryogenic storage tank 7, and a drying chamber 8. The liquid nitrogen conversion tank 6, the cryogenic storage tank 7, and the drying chamber 8 are sequentially arranged between the reactor body 1 and the shell 2. The drying chamber 8 is filled with zeolite molecular sieves 9. A cavity is formed in the wall of the reactor body 1, and a spiral tube 12 is installed in the cavity. One end of the spiral tube 12 is sealed to the cryogenic storage tank 7. A nitrogen tank 3 and a waste gas collection tank 4 are provided on the side of the liquid nitrogen conversion tank 6 away from the cryogenic storage tank 7, and a pipe is sealed between the nitrogen tank 3 and the liquid nitrogen conversion tank 6. The other end of the spiral tube 12 is sealed to the nitrogen tank 3. A flexible hose 14 is sealed between the drying chamber 8 and the nitrogen injection hole on the mounting block 27. The top of the reactor body 1 is equipped with... The vessel has a cover plate 5, which is fixedly connected to the vessel body 1 by multiple latches. Nitrogen is recovered and stored through a nitrogen tank 3. The nitrogen in the nitrogen tank 3 is converted into liquid nitrogen through a liquid nitrogen conversion tank 6 and stored in a low-temperature storage tank 7. The liquid nitrogen can enter the spiral tube 12, where it rapidly vaporizes and absorbs heat to cool the vessel body 1. After that, it can be returned to the nitrogen tank 3 for recovery. The liquid nitrogen can also enter the drying box 8 for vaporization, and the moisture in the nitrogen is removed by the microporous structure of the zeolite molecular sieve 9 and its strong selective adsorption capacity for water molecules, thus achieving nitrogen drying. After drying, the nitrogen enters the hose 14, and then can be injected into the vessel body 1 through either the upper nitrogen inlet pipe 18 or the lower nitrogen inlet pipe 15. It should be noted that the liquid nitrogen conversion tank 6 includes existing devices such as a compressor and a main heat exchanger. The liquid nitrogen conversion technology is an existing mature technology and will not be elaborated on here. The upper half of the vessel body 1 has a nitrogen vent 10 and an upper nitrogen inlet pipe 18 sealed to its outer wall. The lower half of the vessel body 1 has an oxygen outlet 11 and a lower nitrogen inlet pipe 15 sealed to its outer wall. A mounting block 27 is provided between the vessel body 1 and the shell 2, and a nitrogen injection hole is provided on the mounting block 27. Adjustment mechanisms are provided on both sides of the mounting block 27. The adjustment mechanism includes a mounting cylinder 29, a connecting rod 30, a circular plate 38, a fifth spring 39, and multiple limiting rods 41. The connecting rod 30 is fixedly connected to the circular plate 38. The fifth spring 39 is sleeved on the connecting rod 30. Multiple mounting platforms 40 are fixedly connected to the top of the circular plate 38, and the limiting rods 41 are connected to the mounting platforms. The 40-rotation connection allows for adjustment of the nitrogen injection hole position via multiple limit rods 41. The nitrogen injection hole can be adjusted to be aligned with the upper nitrogen inlet pipe 18 or the lower nitrogen inlet pipe 15 as needed. At this time, nitrogen is injected into the upper or lower half of the vessel body 1. Since the oxygen density is greater than that of nitrogen, dry nitrogen can be injected through the upper nitrogen inlet pipe 15, allowing oxygen to be discharged from the oxygen outlet 11. If water vapor is mixed into the nitrogen in the vessel body 1, it will cause the original nitrogen density to decrease. At this time, dry nitrogen can be injected through the lower nitrogen inlet pipe 18, allowing the nitrogen containing water vapor to be discharged from the nitrogen outlet 10. The introduction of dry high-purity nitrogen isolates oxygen and water vapor, preventing the oxidation and hydrolysis of amines.

[0015] Reference Figure 10As shown, mounting plates 13 are symmetrically fixed on both sides of the mounting block 27. Mounting holes 37 are provided on the mounting plates 13, and the end of the mounting cylinder 29 is inserted into the mounting hole 37. A mounting cavity 36 is provided inside the mounting cylinder 29. A circular plate 38, a fifth spring 39, and multiple limiting rods 41 are all disposed within the mounting cavity 36. The circular plate 38 is slidably connected within the mounting cavity 36. The bottom end of the connecting rod 30 slides through the bottom of the mounting cylinder 29. Both ends of the fifth spring 39 are fixedly connected to the circular plate 38 and the inner wall of the mounting cavity 36, respectively. Multiple movable blocks 43 are fixedly connected within the mounting cavity 36. Movable grooves 42 are provided on the limiting rods 41, and the movable blocks 43 are movably connected within the movable grooves 42. A cylinder 31 is provided between the cylinder 29 and the housing 2, and the cylinder 31 is fixedly connected to the housing 2. The output end of the cylinder 31 is fixedly connected to the connecting rod 30. A fourth spring 32 is sleeved on the cylinder 31. The two ends of the fourth spring 32 are fixedly connected to the housing 2 and the mounting cylinder 29, respectively. It should be noted that the fourth spring 32 is used to support the mounting cylinder 29, and the fifth spring 39 is used to reset the limiting rod 41. The elastic force of the fourth spring 32 is much greater than that of the fifth spring 39, so it will not affect the driving of the limiting rod 41. The cross-sectional area of ​​the fourth spring 32 is smaller than that of the mounting cylinder 29. When the limiting rod 41 is extended out of the mounting cavity 36, it will not affect the movement of the mounting plate 13. In use, first, the oxygen in the vessel body 1 is discharged. Then, the cylinder 31 below the mounting block 27 is activated. The cylinder 31 drives the connecting rod 30 and the circular plate 38 to move. The circular plate 38 stretches the fifth spring 39 and drives the limiting rod 41 to rotate, causing the limiting rod 41 to extend out of the mounting cavity 36. When the mounting platform 40 abuts against the top of the mounting cavity 36, the limiting rod 41 is in a horizontal state. At this time, the connecting rod 30 drives the mounting cylinder 29 to move upward. Under the action of the limiting rod 41, the mounting cylinder 29 drives the mounting plate 13 and the mounting block 27 to move upward, so that the nitrogen injection hole on the mounting block 27 is aligned with the upper nitrogen inlet pipe 18. During this process, the drive block 28 on the mounting block 27 squeezes the guide. Block 35 causes the cover 19 to tilt, and the moving mounting block 27 will continuously squeeze the cover 19, opening the cover 19. Dry nitrogen is injected from the upper nitrogen inlet pipe 18, and the oxygen in the vessel 1 is discharged into the waste gas collection box 4 from the oxygen outlet 11. When the nitrogen in the vessel 1 is mixed with water vapor, the cylinder 31 above the mounting block 27 is activated. Under the action of the cylinder 31 and the limit rod 41, the mounting block 27 is pushed down and the cover 19 at the opening of the lower nitrogen inlet pipe 15 is opened, so that the nitrogen injection hole on the mounting block 27 is aligned with the lower nitrogen inlet pipe 15. Dry nitrogen is injected from the lower nitrogen inlet pipe 15, and the nitrogen containing water vapor in the vessel 1 is discharged into the nitrogen tank 3 from the nitrogen outlet 10. It should be noted that cylinder 31 is a press-fit single-acting cylinder. When air is supplied, the piston rod extends, and when air is cut off, the built-in spring automatically pushes the piston rod back. The structure is simple, and it can automatically reset without an external air source after power failure. The specific model and specifications of cylinder 31 need to be selected and determined according to the actual specifications of the device. The specific selection calculation method adopts the existing technology in this field, so it will not be described in detail.

[0016] Reference Figure 5 and Figure 8 As shown, a cover 19 is rotatably connected to the side wall of both the upper nitrogen inlet pipe 18 and the lower nitrogen inlet pipe 15. A clamping mechanism is provided between the cover 19 and the housing 2. The clamping mechanism includes a round rod 22, a slider 23, a connecting rod 20, and multiple mounting rods 21. The multiple mounting rods 21 are all fixedly connected to the housing 2. The round rod 22 is fixedly installed between the multiple mounting rods 21. The slider 23 is slidably connected between the multiple mounting rods 21. The round rod 22 slides through the slider 23. A first connecting platform 33 and a second connecting platform 34 are fixedly connected to the cover 19 and the slider 23, respectively. The two ends of the connecting rod 20 are rotatably connected to the first connecting platform 33 and the second connecting platform 34, respectively. A second spring 24 is sleeved on the round rod 22. The two ends of the second spring 24 are fixedly connected to the slider 23 and the housing 2, respectively. The cross-section of the drive block 28 is a right triangle, and the cross-section of the guide block 35 is a right trapezoid.

[0017] During use, the drive block 27 moves, and the drive block 28 on the drive block 27 presses the guide block 35, causing the cover 19 to tilt. The moving drive block 27 will continue to press the cover 19. Under the action of the connecting rod 20, the slider 23 is pushed to compress the second spring 24, opening the cover 19. Dry nitrogen is injected from the upper nitrogen inlet pipe 18, and the oxygen in the vessel 1 is discharged into the waste gas collection box 4 from the oxygen outlet 11. When the drive block 27 is removed, under the reset action of the second spring 24, the connecting rod 20 is driven to press the cover 19 to fit with the pipe opening, achieving a seal. The operation is simple and does not require separate control by personnel.

[0018] A guide block 35 is fixedly connected to the end of the cap 19. Drive blocks 28 are symmetrically fixed at the upper and lower ends of the mounting block 27. Mounting posts 25 are symmetrically fixed inside the housing 2, and the mounting posts 25 slide through the mounting plate 13. Two third springs 26 are sleeved on the mounting posts 25. The two ends of the third springs 26 are fixedly connected to the mounting plate 13 and the housing 2, respectively. By setting the third springs 26 to support the mounting plate 13 and the mounting block 27, the adjustment mechanism, in the non-working state, makes the nitrogen injection hole on the mounting block 27 between the upper nitrogen inlet pipe 18 and the lower nitrogen inlet pipe 15.

[0019] A first spring 17 is fixedly connected inside both the nitrogen vent 10 and the oxygen outlet 11. A plug 16 is slidably connected inside both the nitrogen vent 10 and the oxygen outlet 11. The end of the first spring 17 is fixedly connected to the plug 16. The nitrogen vent 10 and the oxygen outlet 11 are respectively sealed to the nitrogen tank 3 and the waste gas collection tank 4 to apply pressure to the gas in the vessel body 1. When the gas enters the nitrogen vent 10 and the oxygen outlet 11, it will squeeze the plug 16 and compress the first spring 17, which can discharge the gas and stop the pressure delivery. The compressed first spring 17 returns to its original position and pushes the plug 16 to block the nitrogen vent 10 and the oxygen outlet 11, preventing the gas in the vessel body 1 from escaping.

[0020] In summary: During operation, the oxygen in the vessel 1 is first discharged. The cylinder 31 below the mounting block 27 is then activated. The cylinder 31 drives the connecting rod 30 and the circular plate 38 to move. The circular plate 38 stretches the fifth spring 39 and drives the limiting rod 41 to rotate, causing the limiting rod 41 to extend out of the mounting cavity 36. When the mounting platform 40 abuts against the top of the mounting cavity 36, the limiting rod 41 is in a horizontal state. At this time, the connecting rod 30 drives the mounting cylinder 29 to move upward. Under the action of the limiting rod 41, the mounting cylinder 29 drives the mounting plate 13 and the mounting block 27 to move upward, so that the nitrogen injection hole on the mounting block 27 is aligned with the upper nitrogen inlet pipe 18. During this process, the driving block 28 on the mounting block 27 squeezes the guide block 35, causing the cover 19 to tilt. The moving mounting block 27 will continue to squeeze the cover 19, opening the cover 19. Dry nitrogen is injected from the upper nitrogen inlet pipe 18, and the oxygen in the vessel 1 is discharged from the oxygen outlet 11 into the waste gas collection box 4. When the nitrogen gas in the vessel body 1 is mixed with water vapor, the cylinder 31 above the mounting block 27 is activated. Under the action of the cylinder 31 and the limit rod 41, the mounting block 27 is pushed down and the cover 19 at the opening of the lower nitrogen inlet pipe 15 is opened, so that the nitrogen injection hole on the mounting block 27 is opposite to the lower nitrogen inlet pipe 15. Dry nitrogen gas is injected from the lower nitrogen inlet pipe 15, and the nitrogen gas containing water vapor in the vessel body 1 is discharged into the nitrogen tank 3 from the nitrogen discharge port 10. Nitrogen gas in nitrogen tank 3 is converted into liquid nitrogen in liquid nitrogen conversion tank 6 and stored in low temperature storage tank 7. Liquid nitrogen can enter spiral tube 12, rapidly vaporize and absorb heat to cool the vessel body 1. Liquid nitrogen can also enter drying box 8 to vaporize and then be dried by zeolite molecular sieve 9 before entering hose 14. Then, it can be injected into the vessel body 1 from either the upper nitrogen inlet pipe 18 or the lower nitrogen inlet pipe 15.

[0021] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A reaction vessel for producing pharmaceutical intermediate amine compounds, comprising a vessel body (1), a shell (2), a liquid nitrogen conversion tank (6), a cryogenic storage tank (7), and a drying oven (8), characterized in that: The liquid nitrogen conversion tank (6), the cryogenic storage tank (7) and the drying box (8) are arranged sequentially between the vessel body (1) and the shell (2). The drying box (8) is filled with zeolite molecular sieve (9). The vessel body (1) has a cavity in its tank wall, and a spiral tube (12) is provided in the cavity. One end of the spiral tube (12) is sealed to the cryogenic storage tank (7). The liquid nitrogen conversion tank (6) is provided with a nitrogen tank (3) and a waste gas collection tank (4) on the side away from the cryogenic storage tank (7). A pipe is sealed between the nitrogen tank (3) and the liquid nitrogen conversion tank (6). The other end of the spiral tube (12) is sealed to the nitrogen tank (3). The upper half of the vessel body (1) is sealed with a nitrogen discharge port (10) and an upper nitrogen inlet pipe (18). The lower half of the vessel body (1) is sealed with an oxygen outlet port (11) and a lower nitrogen inlet pipe (15). An installation block (27) is provided between the vessel body (1) and the shell (2), and a nitrogen injection hole is provided on the installation block (27). An adjustment mechanism is provided on both sides of the installation block (27). The adjustment mechanism includes an installation cylinder (29), a connecting rod (30), a circular plate (38), a fifth spring (39), and multiple limiting rods (41). The connecting rod (30) is fixedly connected to the circular plate (38). The fifth spring (39) is sleeved on the connecting rod (30). Multiple mounting platforms (40) are fixedly connected to the top of the circular plate (38), and the limiting rods (41) are rotatably connected to the mounting platforms (40).

2. The pharmaceutical intermediate amine production reactor according to claim 1, characterized in that: Mounting plates (13) are symmetrically fixed on both sides of the mounting block (27). Mounting holes (37) are provided on the mounting plates (13), and the end of the mounting cylinder (29) is inserted into the mounting holes (37). A mounting cavity (36) is provided inside the mounting cylinder (29). The circular plate (38), the fifth spring (39), and multiple limiting rods (41) are all set in the mounting cavity (36).

3. The pharmaceutical intermediate amine production reactor according to claim 2, characterized in that: The circular plate (38) is slidably connected in the mounting cavity (36). The bottom end of the connecting rod (30) slides through the bottom of the mounting cylinder (29). The two ends of the fifth spring (39) are fixedly connected to the circular plate (38) and the inner wall of the mounting cavity (36), respectively. Multiple movable blocks (43) are fixedly connected in the mounting cavity (36). The limiting rod (41) has a movable groove (42), and the movable blocks (43) are movably connected in the movable groove (42).

4. The pharmaceutical intermediate amine production reactor according to claim 1, characterized in that: A cylinder (31) is provided between the mounting cylinder (29) and the housing (2), and the cylinder (31) is fixedly connected to the housing (2). The output end of the cylinder (31) is fixedly connected to the connecting rod (30). A fourth spring (32) is sleeved on the cylinder (31), and the two ends of the fourth spring (32) are fixedly connected to the housing (2) and the mounting cylinder (29) respectively.

5. The pharmaceutical intermediate amine production reactor according to claim 2, characterized in that: Both the upper nitrogen inlet pipe (18) and the lower nitrogen inlet pipe (15) are rotatably connected to a cover (19). A clamping mechanism is provided between the cover (19) and the housing (2). The clamping mechanism includes a round rod (22), a slider (23), a connecting rod (20), and multiple mounting rods (21). The multiple mounting rods (21) are fixedly connected to the housing (2). The round rod (22) is fixedly installed between the multiple mounting rods (21). The slider (23) is slidably connected between the multiple mounting rods (21). The round rod (22) slides through the slider (23).

6. The pharmaceutical intermediate amine production reactor according to claim 5, characterized in that: The cover (19) and the slider (23) are respectively fixedly connected to the first connecting platform (33) and the second connecting platform (34). The two ends of the connecting rod (20) are rotatably connected to the first connecting platform (33) and the second connecting platform (34) respectively. The round rod (22) is fitted with a second spring (24). The two ends of the second spring (24) are fixedly connected to the slider (23) and the shell (2) respectively.

7. The pharmaceutical intermediate amine production reactor according to claim 5, characterized in that: The end of the cover (19) is fixedly connected to a guide block (35), the upper and lower ends of the mounting block (27) are symmetrically fixed with driving blocks (28), the housing (2) is symmetrically fixed with mounting posts (25), and the mounting posts (25) slide through the mounting plate (13). Two third springs (26) are sleeved on the mounting posts (25), and the two ends of the third springs (26) are fixedly connected to the mounting plate (13) and the housing (2) respectively.

8. The pharmaceutical intermediate amine production reactor according to claim 1, characterized in that: A first spring (17) is fixedly connected inside both the nitrogen discharge port (10) and the oxygen outlet port (11), and a plug (16) is slidably connected inside both the nitrogen discharge port (10) and the oxygen outlet port (11). The end of the first spring (17) is fixedly connected to the plug (16).

9. The pharmaceutical intermediate amine production reactor according to claim 8, characterized in that: The nitrogen outlet (10) and oxygen outlet (11) are respectively sealed and connected to the nitrogen tank (3) and the waste gas collection tank (4).

10. The pharmaceutical intermediate amine production reactor according to claim 1, characterized in that: A hose (14) is sealed between the drying oven (8) and the nitrogen injection hole on the mounting block (27). The top of the vessel body (1) is provided with a cover plate (5), which is fixedly connected to the vessel body (1) by multiple latches.

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