A MOF / bentonite composite particle for green anesthesia and a preparation method and application thereof

Abstract

The application provides a MOF / bentonite composite particle for green anesthesia and a preparation method and application thereof, and the MOF / bentonite composite particle for green anesthesia comprises raw materials: a ZIF-8 composite material, calcium hydroxide, sodium silicate, bentonite, ethyl violet and an organic binder; the ZIF-8 composite material comprises the following preparation raw materials: ZIF-8, behenic acid and dopamine hydrochloride. The MOF / bentonite composite particle for green anesthesia provided by the application exhibits excellent comprehensive performance in a medical carbon dioxide adsorption scene.

Description

Technical Field

[0001] This application relates to the field of adsorption materials technology, and in particular to a MOF / bentonite composite particle for green anesthesia, its preparation method and application. Background Technology

[0002] In clinical anesthesia, a breathing circuit is typically used to maintain stable respiratory and circulatory function in patients. Carbon dioxide adsorption and purification within the anesthesia breathing circuit is a crucial step in ensuring patient respiratory safety. To prevent patients from re-inhaling exhaled carbon dioxide, a carbon dioxide adsorbent must be incorporated into the circuit. Currently, commonly used carbon dioxide adsorbents in clinical practice are primarily calcium lime and soda lime, whose main components are alkaline substances such as calcium hydroxide and sodium hydroxide, which achieve the fixation and removal of carbon dioxide through a chemical reaction. However, existing commercially available adsorbents generally suffer from the following technical defects: 1. The mechanical strength is relatively low, and it is easy to pulverize and shed dust during use, which may cause blockage of the breathing circuit and contamination of anesthetic gas, posing a clinical safety hazard; 2. The adsorption efficiency and adsorption capacity are limited. Under high flow rate and high concentration of carbon dioxide, it is easy to become saturated quickly and cannot meet the stable adsorption requirements of long-term surgery. 3. The simple pore structure results in high gas mass transfer resistance, slow carbon dioxide diffusion rate, and poor overall adsorption kinetics.

[0003] With the upgrading of modern medical concepts, green anesthesia has become the core direction of clinical anesthesia development. Green anesthesia requires anesthesia consumables to be low in dust and irritation, stable and long-lasting, reduce the frequency of medical waste replacement, and reduce the risk of pipeline contamination. Traditional commercially available soda lime and calcium lime adsorbents have problems such as easy pulverization, rapid saturation, and large replacement volumes per surgery. Frequent replacement of adsorbents increases the waste of consumables and the generation of medical solid waste, which does not meet the requirements of green anesthesia for low carbon emissions, low consumables, and safe and long-lasting use. At the same time, traditional adsorbents have poor moisture resistance, and their adsorption capacity drops sharply after moisture intrusion, further shortening their service life and hindering the clinical implementation of green anesthesia.

[0004] Metal-organic frameworks (MOFs) are crystalline porous materials formed by the self-assembly of metal ions / metal clusters and organic ligands through coordination bonds. They possess characteristics such as large specific surface area, high porosity, precise controllability of pore size and structure, and easy functional modification, exhibiting significant advantages in gas adsorption, separation, and capture. Among them, the zeolite imidazolium ester framework material ZIF-8, as a typical zinc-based MOF material, forms a zeolite-like topology through the coordination of zinc ions and 2-methylimidazolium. It exhibits high chemical stability, well-ordered channels, and excellent gas adsorption performance, showing outstanding application potential in carbon dioxide adsorption and gas separation scenarios.

[0005] However, pure ZIF-8 powder is difficult to mold alone, has low strength, and is prone to pulverization, which cannot meet the requirements for long-term use of medical adsorbents. Although existing technologies can granulate ZIF-8 composites, they generally suffer from problems such as pore blockage and low mechanical strength after molding. At the same time, the products have insufficient moisture resistance, making them difficult to adapt to medical use environments, which restricts their industrialization and clinical application. Summary of the Invention

[0006] This application is made in view of the above-mentioned problems, and its purpose is to provide a green anesthesia MOF / bentonite composite particle, which is environmentally friendly and has good adsorption effect.

[0007] The details are as follows: The first aspect of this application provides a green anesthesia MOF / bentonite composite particle, comprising the following raw materials in parts by weight: ZIF-8 composite material, calcium hydroxide, sodium silicate, bentonite, ethyl violet and organic binders; The ZIF-8 composite material comprises the following raw materials: ZIF-8, behenic acid, and dopamine hydrochloride.

[0008] According to a first aspect of the present invention, a green anesthesia MOF / bentonite composite particle has the following beneficial effects: This application uses ZIF-8 composite material as the core MOF functional component, achieving efficient physical adsorption of carbon dioxide through its high specific surface area and abundant pores. Behenic acid improves the hydrophobicity of the material, reduces water vapor interference, and enhances adsorption stability. Polydopamine coating strengthens the structure, prevents leakage of the colorimetric agent, and improves the interfacial bonding between components. Calcium hydroxide, as the main adsorption component, has strong chemical adsorption capacity and large capacity. Bentonite improves particle formability, mechanical strength, and surface roundness, optimizes gas diffusion channels, and reduces the risk of pulverization during use. Sodium silicate and organic binders synergistically enhance the stability of the particle structure. The components are rationally proportioned, with significant synergistic effects, resulting in excellent overall performance. It can be used for carbon dioxide adsorption and purification in clinical anesthesia respiratory circuits. This product produces less dust, has high mechanical strength, and a long cycle life, reducing consumable replacements and medical waste. Its dual hydrophobic structure is suitable for high-humidity anesthesia environments, meeting the clinical needs for long-lasting, low-carbon green anesthesia.

[0009] According to some embodiments of the present invention, the mass fractions of the raw materials for the MOF / bentonite composite particles used in green anesthesia are as follows: 10 parts ZIF-8 composite material, 40-50 parts calcium hydroxide, 10-15 parts sodium silicate, 5-10 parts bentonite, 2-5 parts organic binder, and 0.1-0.3 parts ethyl violet.

[0010] According to some embodiments of the present invention, the organic adhesive is a water-soluble polymeric adhesive.

[0011] According to some embodiments of the present invention, the water-soluble polymeric binder is at least one selected from hydroxypropyl methylcellulose, polyvinyl ketone, sodium carboxymethyl cellulose, and chitosan.

[0012] Water-soluble polymer binders have mild adhesion, good formability, high biocompatibility, and no toxic residues. They do not clog pores after drying, ensuring particle strength and high air permeability, making them more suitable for medical applications.

[0013] The second aspect of this application provides a method for preparing the above-mentioned MOF / bentonite composite particles for green anesthesia, comprising the following steps: Mixing, extrusion, shaping, and drying.

[0014] According to some embodiments of the present invention, the preparation method of ZIF-8 composite material during the mixing process includes the following steps: ZIF-8 and behenic acid were mixed to prepare behenic acid-modified ZIF-8; Behenic acid-modified ZIF-8 was mixed with dopamine hydrochloride.

[0015] According to some embodiments of the present invention, the method for preparing ZIF-8 includes the following steps: S11: Mix the template solution, zinc salt and 2-methylimidazole solution to obtain the first mixture; S12: Mix the first mixture with ethanol and acetic acid, collect the solid phase and then dry it under vacuum.

[0016] According to some embodiments of the present invention, the template solution in step S11 is a polystyrene-b-polyoxyethylene diblock copolymer dissolved in a solvent.

[0017] According to some embodiments of the present invention, the molecular weight of the polystyrene is 5000~10000.

[0018] According to some embodiments of the present invention, the molecular weight of the polyoxyethylene is 2500-5000.

[0019] According to some embodiments of the present invention, the solvent is anhydrous ethanol.

[0020] According to some embodiments of the present invention, the zinc salt is at least one of zinc nitrate hexahydrate and zinc sulfate.

[0021] According to some embodiments of the present invention, the zinc salt is zinc sulfate.

[0022] According to some embodiments of the present invention, the Zn 2+ The molar ratio of 2-methylimidazole to template is 1:6~8:0.1~0.2.

[0023] According to some embodiments of the present invention, in step S11, the reaction temperature is 50°C to 60°C.

[0024] According to some embodiments of the present invention, in step S11, the reaction time is 3h to 5h.

[0025] According to some embodiments of the present invention, in step S12, the volume ratio of ethanol to acetic acid is 9~10:1. According to some embodiments of the present invention, in step S12, the mixing time is 24h~25h.

[0026] According to some embodiments of the present invention, the vacuum degree of vacuum drying is -0.08MPa to -0.1MPa.

[0027] According to some embodiments of the present invention, the vacuum drying time is 12h~13h.

[0028] According to some embodiments of the present invention, the vacuum drying temperature is 50°C to 60°C.

[0029] According to some embodiments of the present invention, the preparation method of the modified ZIF-8 includes the following steps: Behenic acid, ZIF-8, and solvent were reacted, the solid phase was collected, and then dried under vacuum.

[0030] According to some embodiments of the present invention, the solvent is anhydrous ethanol.

[0031] According to some embodiments of the present invention, the mass ratio of behenic acid to ZIF-8 is 0.16 to 0.20:1.

[0032] According to some embodiments of the present invention, the vacuum degree of vacuum drying is -0.08MPa to -0.1MPa.

[0033] According to some embodiments of the present invention, the vacuum drying time is 12h~13h.

[0034] According to some embodiments of the present invention, the vacuum drying temperature is 50°C to 60°C.

[0035] According to some embodiments of the present invention, the preparation method of the ZIF-8 composite material includes the following steps: Mix behenic acid-modified ZIF-8 with Tris buffer, then add dopamine hydrochloride and collect the solid phase.

[0036] According to some embodiments of the present invention, the pH of the Tris buffer solution is 8-9.

[0037] According to some embodiments of the present invention, the molar concentration of the Tris buffer is 10 mM.

[0038] According to some embodiments of the present invention, the mass-to-volume ratio of the Tris buffer and dopamine hydrochloride is 90-100:1.

[0039] According to some embodiments of the present invention, the reaction temperature is 24°C to 25°C.

[0040] According to some embodiments of the present invention, the reaction time is 20 min to 40 min.

[0041] According to some embodiments of the present invention, the mass ratio of behenic acid-modified ZIF-8 to dopamine hydrochloride is 8~12:1.

[0042] According to some embodiments of the present invention, the reaction temperature is 24°C to 25°C.

[0043] According to some embodiments of the present invention, the reaction time is 12h to 13h.

[0044] According to some embodiments of the present invention, in the preparation method of the MOF / bentonite composite particles for green anesthesia, the mixing process involves mixing the raw materials.

[0045] According to some embodiments of the present invention, the mixing time is 25 min to 35 min.

[0046] According to some embodiments of the present invention, the rotational speed during the mixing process is 10 r / min to 20 r / min.

[0047] According to some embodiments of the present invention, the screen aperture during the extrusion process is 2mm to 3mm.

[0048] According to some embodiments of the present invention, the shaping process is a rounding shaping.

[0049] According to some embodiments of the present invention, the time for the rounding and shaping is 8 min to 10 min.

[0050] According to some embodiments of the present invention, the rotational speed of the rounding process is 270 r / min to 330 r / min.

[0051] According to some embodiments of the present invention, the drying process is a three-stage drying process.

[0052] According to some embodiments of the present invention, the three-stage drying process consists of a first drying, a second drying, and a third drying.

[0053] According to some embodiments of the present invention, the drying temperature of the first drying is 40°C to 50°C.

[0054] According to some embodiments of the present invention, the drying time for the first drying is 1.5h to 2.5h.

[0055] According to some embodiments of the present invention, the drying temperature of the second drying is 60°C to 70°C.

[0056] According to some embodiments of the present invention, the drying time for the second drying is 2h to 3h.

[0057] According to some embodiments of the present invention, the drying temperature of the third drying is 80°C to 90°C.

[0058] According to some embodiments of the present invention, the drying time for the third drying is 3 to 4 hours.

[0059] The third aspect of this application provides the application of the above-mentioned MOF / bentonite composite particles for green anesthesia in the field of carbon dioxide adsorbents for green anesthesia breathing circuits. Attached Figure Description

[0060] To more clearly illustrate the technical solutions in the embodiments of this drawing or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this drawing. For those skilled in the art, other drawings can be obtained based on the structures shown in these drawings without creative effort.

[0061] Figure 1 The adsorption-desorption isotherm of the MOF / bentonite composite particles for green anesthesia obtained in Example 1 is shown below. Figure 2 The image shows the pore size distribution curve of the MOF / bentonite composite particles for green anesthesia obtained in Example 1. Figure 3 The image shows the adsorption-desorption isotherm of the composite particles obtained in Comparative Example 1.

[0062] The purpose, features, and advantages of this accompanying drawing will be further explained in conjunction with the embodiments and with reference to the accompanying drawing. Detailed Implementation

[0063] To make the objectives, technical solutions, and advantages of this application clearer, the following description and illustration are provided in conjunction with embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the scope of this application. All other embodiments obtained by those skilled in the art based on the embodiments provided in this application without inventive effort are within the scope of protection of this application.

[0064] Obviously, the following description is merely some examples or embodiments of this application. Those skilled in the art can apply this application to other similar scenarios without any inventive effort. Furthermore, it is understood that although the effort involved in such development may be complex and lengthy, for those skilled in the art related to the content disclosed in this application, any changes to design, manufacturing, or production based on the technical content disclosed in this application are merely conventional technical means and should not be construed as insufficient disclosure of the content of this application.

[0065] Unless otherwise specified, the terms "comprising" and "including" as used in this application can be open-ended or closed-ended. For example, "comprising" and "including" can mean that other components not listed may also be included, or that only the listed components may be included.

[0066] Unless otherwise specified, the term "or" is inclusive in this application. For example, the phrase "A or B" means "A, B, or both A and B". More specifically, the condition "A or B" is satisfied by any of the following conditions: A is true (or exists) and B is false (or does not exist); A is false (or does not exist) and B is true (or exists); or both A and B are true (or exist).

[0067] The following are some of the raw materials used in the embodiments of this application: Hydroxypropyl methylcellulose CAS No.: 9004-65-3; PS (5k) b PEO (2.5k) The selected materials are PS with a molecular weight of 5000 and PEO with a molecular weight of 2500. Behenicol CAS No.: 112-85-6.

[0068] The preparation method of ZIF-8 consists of the following steps: PS (5k) b PEO (2.5k) Dissolve in anhydrous ethanol to prepare a template solution with a concentration of 6 g / L; Dissolve ZnSO4 in anhydrous ethanol to prepare a 0.3 mol / L zinc salt solution; Dissolve 2-methylimidazole in anhydrous ethanol to prepare a ligand solution with a concentration of 7.6 mol / L; According to Zn 2+The above three solutions were mixed in a molar ratio of 1:8:0.1 for 2-methylimidazole and template, stirred at 25°C for 10 min, then heated to 60°C and stirred for 4 h. The solid was collected and washed three times with anhydrous ethanol to obtain the first mixture. The first mixture was extracted using the Soxhlet extraction method. The mixture was added to a mixture of ethanol and acetic acid (volume ratio of ethanol to acetic acid 9:1) and extracted at 85°C for 24 h. After extraction, the mixture was washed three times with anhydrous ethanol and then dried under vacuum at 60°C and -0.1 MPa for 12 h to obtain ZIF-8.

[0069] Example 1 A green anesthesia MOF / bentonite composite particle comprises the following raw materials in parts by mass: 10 parts ZIF-8 composite material, 40 parts calcium hydroxide, 10 parts sodium silicate, 5 parts bentonite, 0.2 parts ethyl violet, and 5 parts hydroxypropyl methylcellulose.

[0070] The preparation method of ZIF-8 composite material consists of the following steps: Behenic acid and anhydrous ethanol were mixed (60°C) to prepare a behenic acid mixture. The mixture of ZIF-8 and behenic acid (ZIF-8 to behenic acid mass ratio of 1:0.18) was ultrasonically dispersed for 15 min (power of 200W), and stirred at 60℃ and 500 rpm for 120 min. The solid phase was collected, washed, and then vacuum dried (temperature of 50℃, pressure of -0.1MPa, time of 12 h) to obtain behenic acid modified ZIF-8. Behenic acid-modified ZIF-8 and Tris buffer (10 mM, pH=8.5) were mixed and stirred at 25°C for 30 min. Dopamine hydrochloride was then added, and polymerization was carried out at 25°C for 12 h. The solid was collected, washed, and then vacuum dried (at 50°C, -0.1 MPa, for 12 h). The washing process is as follows: Wash three times with a mixture of ethanol and water (ethanol to water volume ratio of 1:1); then wash three times with deionized water. After each wash, centrifuge (centrifuge speed of 10000 rpm, time of 10 min).

[0071] The mass ratio of behenic acid-modified ZIF-8 to dopamine hydrochloride was 8:1; The mass-to-volume ratio of Tris buffer to dopamine hydrochloride is 100:1 (g / mL).

[0072] like Figure 1 As shown, the preparation method of this green anesthesia MOF / bentonite composite particle includes the following steps: S1. Wet mixing: Ethyl violet, ZIF-8 composite material, bentonite, and sodium silicate are added to water and stirred for 30 minutes to obtain the first mixed solution; the first mixed solution is sprayed evenly onto the surface of calcium hydroxide powder by atomization spraying and dried at 40°C for 6 hours to obtain premixed powder. S2. Extrusion granulation: Add a small amount of water to the premixed powder and mix thoroughly to adjust the condition. Control the overall moisture content of the material to 20% to form a plastic mud ball. Extrude the mud ball with a screen aperture of 2.0 mm to obtain a cylindrical wet strip with a diameter of about 2.0 mm. S3. Rounding and shaping: The extruded wet strip is rounded at a speed of 300 r / min for 10 min to obtain smooth microspheres. The D50 of the microspheres is 1.8 mm. S4. Gradient drying: The micro-pellets are laid flat and dried in three stages. S41. First drying: temperature 45℃, time 2h; S42. Second drying: temperature 65℃, time 2.5h; S43. Third drying: temperature 85℃, time 3.5h.

[0073] Example 2 A green anesthesia MOF / bentonite composite particle differs from Example 1 in that: The mass ratio of ZIF-8 to behenic acid is 1:0.2.

[0074] The preparation method of the MOF / bentonite composite particles for green anesthesia is as described in Example 1.

[0075] Example 3 A green anesthesia MOF / bentonite composite particle differs from Example 1 in that: The mass ratio of modified ZIF-8 to dopamine hydrochloride is 12:1.

[0076] The preparation method of the MOF / bentonite composite particles for green anesthesia is as described in Example 1.

[0077] Example 4 A green anesthesia MOF / bentonite composite particle differs from Example 1 in that: The mass-to-volume ratio of Tris buffer to dopamine hydrochloride is 90:1 (g / mL).

[0078] The preparation method of the MOF / bentonite composite particles for green anesthesia is as described in Example 1.

[0079] Comparative Example 1 A composite particle, which differs from Example 1 in that: Replace ZIF-8 composite material with ZIF-8.

[0080] The preparation method of the composite particles is as described in Example 1.

[0081] Comparative Example 2 A composite particle, which differs from Example 1 in that: The ZIF-8 composite material was replaced with behenic acid-modified ZIF-8.

[0082] The preparation method of behenic acid modified ZIF-8 is as follows: Behenic acid and anhydrous ethanol were mixed (60°C) to prepare a behenic acid mixture. The mixture of ZIF-8 and behenic acid (mass ratio of ZIF-8 to behenic acid 1:0.18) was ultrasonically dispersed for 15 min (power 200W), and stirred at 60℃ and 500 rpm for 120 min. The solid phase was collected, washed, and then vacuum dried (temperature 50℃, pressure -0.1MPa, time 12h) to obtain behenic acid modified ZIF-8.

[0083] The preparation method of the composite particles is as described in Example 1.

[0084] Comparative Example 3 A composite particle, which differs from Example 1 in that the ZIF-8 composite material is replaced with dopamine hydrochloride modified ZIF-8.

[0085] The preparation method of dopamine hydrochloride modified ZIF-8 is as follows: ZIF-8 and Tris buffer (10 mM, pH=8.5) were mixed and stirred at 25°C for 30 min. Dopamine hydrochloride was then added, and polymerization was carried out at 25°C for 12 h. The solid was collected, washed, and then vacuum dried (50°C, -0.1 MPa, 12 h). The washing process is as follows: Wash three times with a mixture of ethanol and water (ethanol to water volume ratio of 1:1); then wash three times with deionized water. After each wash, centrifuge (centrifuge speed of 10000 rpm, time of 10 min).

[0086] The mass ratio of ZIF-8 to dopamine hydrochloride is 8:1; The mass-to-volume ratio of Tris buffer to dopamine hydrochloride is 100:1 (g / mL).

[0087] Performance testing: 1. Hole structure parameter testing Referring to GB / T 19587-2017, the low-temperature nitrogen adsorption method was tested using an ASAP 2020 fully automated physical adsorption instrument. Before testing, the samples were pretreated: the composite particles were placed in a sample tube and degassed under vacuum at 80℃ for 4 hours. After pretreatment, high-purity nitrogen adsorption-desorption tests were performed at liquid nitrogen temperature of 77 K to obtain nitrogen adsorption isotherms.

[0088] 2. Carbon dioxide adsorption performance test: According to GB / T 17665-2021, the ASAP 2020 fully automatic physical adsorption instrument was used for testing. The test temperature was set to 25℃ and the test pressure was adjusted to 0.15 bar. The static saturated adsorption capacity of the sample for carbon dioxide (CO2) and nitrogen (N2) was tested respectively.

[0089] 3. Crushing strength (N) test: Test method: Using a universal testing machine, 10 intact particles were randomly selected for radial compression test. The maximum pressure when the particles broke was recorded and the average value was taken. Reference standard: HG / T 2782-2012.

[0090] 4. Adsorption cycle test: Cyclic tests were conducted using an ASAP 2020 fully automated physical adsorption instrument. At 25℃ and 0.15 bar, one cycle consisted of nitrogen adsorption saturation and vacuum desorption regeneration. Adsorption failure was defined as when the adsorption capacity decreased to 80% of the initial value, and the number of effective cycles for the sample was counted.

[0091] The test data for each group in the examples and the comparative examples are shown in Table 1.

[0092] Table 1

[0093] Table 1 shows that the MOF / bentonite composite particles for green anesthesia prepared in Examples 1-4 exhibited excellent carbon dioxide adsorption performance, mechanical strength, and cyclic stability, with Example 1 showing the best overall performance. Compared to the example groups, Comparative Example 1, using unmodified ZIF-8, showed a significant decrease in performance; Comparative Example 2, modified only with behenic acid, and Comparative Example 3, coated only with polydopamine, both showed significantly lower performance than the examples. The results indicate that modifying ZIF-8 with behenic acid and coating it with polydopamine can significantly improve its adsorption capacity, strength, and cyclic stability, meeting the requirements for clinical anesthesia breathing circuits. The samples in Examples 1-4 have high CO2 adsorption capacity, high mechanical strength, excellent hydrophobic and moisture-resistant properties, and recyclability. A single filling can support long-term surgery, significantly reducing the frequency of adsorbent replacement, reducing medical consumable waste, and meeting the stringent requirements of green anesthesia for low solid waste, long-term stability, and low dust safety consumables. In contrast, the comparative samples that have not undergone double-layer hydrophobic coating modification have short cycle life, are prone to pulverization, and have high consumable consumption, making them unsuitable for the clinical use standards of green anesthesia.

[0094] Figure 1 The figure shows the nitrogen adsorption-desorption isotherm of the MOF / bentonite composite particles for green anesthesia obtained in Example 1. The curve shows that the sample exhibits a typical type IV adsorption isotherm with obvious hysteresis loop, which proves that the material has a rich mesoporous structure and well-developed pores, which is conducive to the diffusion and adsorption of carbon dioxide gas.

[0095] Figure 2 The figure shows the pore size distribution curve of the MOF / bentonite composite particles for green anesthesia obtained in Example 1. The figure shows that the pore size of the sample is concentrated in the range of 20 nm to 70 nm. It has a multi-channel structure of mesoporous and macroporous pores. The high specific surface area can provide a large number of CO2 adsorption sites, and the mesoporous channels reduce the gas mass transfer resistance.

[0096] Figure 3 The nitrogen adsorption-desorption isotherm of Comparative Example 1 (composite particles prepared from unmodified pure ZIF) is shown in Figure 1. Compared with Figure 1, it can be seen that its adsorption capacity is low, the hysteresis loop is weak, and the degree of pore structure development is much lower than that of Example 1.

[0097] It should be noted that this application is not limited to the above-described embodiments. The above embodiments are merely examples, and any embodiments with the same structure and effect as the technical concept within the scope of this application are included in the technical scope of this application. Furthermore, various modifications that can be conceived by those skilled in the art to the embodiments, and other ways of constructing by combining some of the constituent elements of the embodiments, without departing from the spirit of this application, are also included in the scope of this application.

Claims

1. A type of MOF / bentonite composite granules for green anesthesia, characterized in that, The MOF / bentonite composite particles used for green anesthesia include the following raw materials: ZIF-8 composite material, calcium hydroxide, sodium silicate, bentonite, ethyl violet and organic binders; The ZIF-8 composite material comprises the following raw materials: ZIF-8, behenic acid, dopamine hydrochloride.

2. The MOF / bentonite composite particles for green anesthesia as described in claim 1, characterized in that, The mass fractions of the raw materials are as follows: 10 parts ZIF-8 composite material, 40-50 parts calcium hydroxide, 10-15 parts sodium silicate, 5-10 parts bentonite, 2-5 parts organic binder, and 0.1-0.3 parts ethyl violet.

3. The MOF / bentonite composite particles for green anesthesia as described in claim 1, characterized in that, The organic adhesive is a water-soluble polymeric adhesive; And / or, the water-soluble polymeric binder is at least one of hydroxypropyl methylcellulose, polyvinylpyrrolidone, sodium carboxymethyl cellulose, and chitosan.

4. A method for preparing MOF / bentonite composite particles for green anesthesia as described in any one of claims 1 to 3, characterized in that, Includes the following steps: Mixing, extrusion, shaping, and drying.

5. The method for preparing MOF / bentonite composite particles for green anesthesia as described in claim 4, characterized in that, The preparation method of ZIF-8 composite material during the mixing process includes the following steps: ZIF-8 and behenic acid were mixed to prepare behenic acid-modified ZIF-8; Behenic acid-modified ZIF-8 was mixed with dopamine hydrochloride.

6. The method for preparing MOF / bentonite composite particles for green anesthesia as described in claim 5, characterized in that, The preparation method of ZIF-8 includes the following steps: S11: Mix the template solution, zinc salt and 2-methylimidazole solution to obtain the first mixture; S12: Mix the first mixture with ethanol and acetic acid, collect the solid phase and then dry it under vacuum.

7. The method for preparing MOF / bentonite composite particles for green anesthesia as described in claim 5, characterized in that, The mass ratio of behenic acid to ZIF-8 is 0.16~0.20:

1.

8. The method for preparing MOF / bentonite composite particles for green anesthesia as described in claim 7, characterized in that, The preparation method of the ZIF-8 composite material includes: Mix behenic acid-modified ZIF-8 with Tris buffer, then add dopamine hydrochloride and mix again, and collect the solid phase.

9. The method for preparing MOF / bentonite composite particles for green anesthesia as described in claim 8, characterized in that, The mass ratio of behenic acid-modified ZIF-8 to dopamine hydrochloride is 8~12:

1.

10. The application of MOF / bentonite composite particles for green anesthesia as described in any one of claims 1 to 3, or MOF / bentonite composite particles for green anesthesia prepared by the preparation method described in any one of claims 4 to 9, in the field of carbon dioxide adsorbents for green anesthesia breathing circuits.

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