Fabric composition containing centella asiatica ingredients and method for preparing the same

Abstract

The present disclosure relates to the technical field of medical consumables, and provides a fabric composition containing a Centella asiatica component and a preparation method thereof. The method comprises: adding a Centella asiatica raw material powder into an ethanol aqueous solution for extraction to obtain a Centella asiatica extract, and performing segmented separation on the Centella asiatica extract to obtain a first Centella asiatica component and a second Centella asiatica component; adding the second Centella asiatica component into a gelatin solution containing a surfactant for dispersion and entrapping treatment to obtain Centella asiatica repair-promoting microparticles, and then adding the Centella asiatica repair-promoting microparticles into a composite hydrogel liquid for crosslinking to obtain Centella asiatica repair-promoting hydrogel; mixing the first Centella asiatica component and an antibacterial spinning solution, and then performing spinning treatment to obtain Centella asiatica antibacterial fixed fabric; and sequentially compounding the Centella asiatica repair-promoting hydrogel, the Centella asiatica antibacterial fixed fabric and a composite breathable fabric to obtain the fabric composition containing the Centella asiatica component. Different Centella asiatica components are retained in the fabric, so that the overall stability and repair promotion are achieved.

Description

Technical Field

[0001] This disclosure relates to the field of medical consumables technology, and more specifically, to a fabric composition containing Centella asiatica and a method for preparing the same. Background Technology

[0002] In the medical field, Centella asiatica components are mainly used for wound repair, skin barrier repair, and scar management. The main active ingredients in Centella asiatica include triterpenoids such as asiaticoside, asiaticoside, asiaticoside, and asiaticoside. These components can promote fibroblast proliferation, collagen production, and extracellular matrix reconstruction, enabling wound tissue to enter the repair stage more quickly. Therefore, they are often used in medical dressings, wound gels, burn care materials, and postoperative repair materials.

[0003] Applying Centella asiatica extract directly to liquid or ointment formulations can easily lead to problems such as uneven application, short contact time, removal through friction, or inconvenience in use. By incorporating it into fabrics, the fabric acts as a carrier to fix and support the Centella asiatica extract, allowing it to distribute on the fiber surface or within the fiber gaps. This ensures continuous contact with the skin during wearing, covering, or bandaging, reducing the loss of active ingredients in a single application and making its effect more stable. Therefore, this incorporation method is more suitable for products such as medical dressings, repair patches, functional gauze, post-operative care materials, wipes, or intimate care fabrics.

[0004] However, the properties of different active ingredients in Centella asiatica extract vary considerably in related technologies. Phenolic acids, flavonoids, and polyphenols are relatively more suitable for binding with the spinning system and fixing in the fiber structure. On the other hand, if repair-promoting ingredients such as asiaticoside, hydroxyasiaticoside, asiatic acid, and hydroxyasiatic acid are directly added to the fabric, they are prone to uneven dispersion, insufficient binding force with the fiber, and loss during friction or washing, resulting in a short effective time. At the same time, when the repair-promoting ingredients are concentrated on the fabric surface, there may be problems such as too rapid release in the early stage and insufficient effective ingredients in the later stage, making it difficult for the fabric to maintain a long-term repair and support effect on the skin or wounds during use.

[0005] It should be noted that the information disclosed in the background section above is only used to enhance the understanding of the background of this disclosure. Summary of the Invention

[0006] The purpose of this disclosure is to provide a fabric composition containing Centella asiatica and its preparation method, which solves the problem that it is difficult to achieve both stable fixation and continuous repair promotion when the active components of Centella asiatica are directly compounded into the fabric.

[0007] Other features and advantages of this disclosure will become apparent from the following detailed description, or may be learned in part by practice of this disclosure.

[0008] According to one aspect of this disclosure, a method for preparing a fabric composition containing Centella asiatica is provided, comprising the steps of: S1. Add Centella asiatica raw material powder to an ethanol aqueous solution for extraction to obtain Centella asiatica extract. Separate the Centella asiatica extract into segments to obtain a first Centella asiatica component and a second Centella asiatica component. The first Centella asiatica component includes phenolic acids, flavonoids and polyphenolic substances, and the second Centella asiatica component includes asiaticoside, hydroxyasiaticoside, asiaticoside and hydroxyasiaticoside. S2. The second Centella asiatica component is added to a gelatin solution containing surfactant for dispersion and encapsulation to obtain Centella asiatica repair-promoting microparticles. Then, the Centella asiatica repair-promoting microparticles are added to a composite hydrogel liquid for cross-linking to obtain Centella asiatica repair-promoting hydrogel. S3. The first Centella asiatica component and the antibacterial spinning solution are mixed and then spun to obtain the Centella asiatica antibacterial fixing fabric. Then, the Centella asiatica repair-promoting hydrogel, the Centella asiatica antibacterial fixing fabric, and the composite breathable fabric are compounded in sequence to obtain a fabric composition containing Centella asiatica components. The antibacterial spinning solution includes antibacterial components and spinning components.

[0009] According to one aspect of this disclosure, a fabric composition containing centella asiatica is provided, which is prepared by a method for preparing a fabric composition containing centella asiatica as described above.

[0010] As can be seen from the above technical solutions, the exemplary embodiments disclosed herein possess at least the following advantages and positive effects: In some embodiments of this disclosure, the technical solutions provided, on the one hand, involve segmenting the Centella asiatica extract and mixing the first Centella asiatica component with the antibacterial spinning solution before spinning. This allows the first Centella asiatica component, including phenolic acids, flavonoids, and polyphenols, to form a Centella asiatica antibacterial fixed fabric along with the antibacterial and spinning components. This solves the problem in the prior art where the Centella asiatica component is difficult to stably fix in the fabric structure when directly added to the fabric, thus achieving the technical effect of fixing the first Centella asiatica component in the fabric and forming a Centella asiatica antibacterial fixed fabric. On the other hand, through... The technique involves dispersing and encapsulating the second asiaticus component in a gelatin solution containing surfactants, and then adding the resulting asiaticus repair-promoting microparticles to a composite hydrogel for cross-linking. This allows the second asiaticus component, including asiaticoside, hydroxyasiaticoside, asiaticoside, and hydroxyasiaticoside, to first form asiaticus repair-promoting microparticles, which are then carried in the asiaticus repair-promoting hydrogel. This technique overcomes the problem that the second asiaticus component is difficult to stably carry and continuously exert its repair-promoting effect when directly compounded into the fabric, and achieves the technical effect of dispersing, encapsulating, and cross-linking the second asiaticus component in the composite structure.

[0011] In summary, this technical solution achieves a combination of stable fixation and continuous repair effects by spinning and fixing the first Centella asiatica component, encapsulating the second Centella asiatica component in microparticles, cross-linking with hydrogel, and then sequentially combining Centella asiatica repair-promoting hydrogel, Centella asiatica antibacterial and fixing fabric, and composite breathable fabric. This allows different Centella asiatica components to be retained in the fabric composition in an appropriate manner, thereby enabling the fabric composition containing Centella asiatica to have both stable fixation and continuous repair-promoting effects.

[0012] It should be understood that the foregoing general description and the following detailed description are exemplary and explanatory only, and are not intended to limit this disclosure. Attached Figure Description

[0013] The accompanying drawings, which are incorporated in and form part of this specification, illustrate embodiments consistent with this disclosure and, together with the description, serve to explain the principles of this disclosure. It is obvious that the drawings described below are merely some embodiments of this disclosure, and those skilled in the art can obtain other drawings based on these drawings without any inventive effort. In the drawings: Figure 1 This is a schematic flowchart illustrating a method for preparing a fabric composition containing Centella asiatica extract in one embodiment. Figure 2 This is a schematic flowchart of step S1 in a method for preparing a fabric composition containing Centella asiatica in one embodiment. Figure 3 This is a schematic flowchart of step S2 in a method for preparing a fabric composition containing Centella asiatica in one embodiment. Figure 4 This is a schematic flowchart of step S3 in a method for preparing a fabric composition containing Centella asiatica in one embodiment. Detailed Implementation

[0014] Exemplary embodiments will now be described more fully with reference to the accompanying drawings. However, these exemplary embodiments can be implemented in many forms and should not be construed as limited to the examples set forth herein; rather, these embodiments are provided so that this disclosure will be more thorough and complete, and will fully convey the concept of the exemplary embodiments to those skilled in the art.

[0015] Furthermore, the described features or characteristics may be combined in any suitable manner in one or more embodiments. Numerous specific details are provided in the following description to give a thorough understanding of embodiments of this disclosure. However, those skilled in the art will recognize that the technical solutions of this disclosure may be practiced without one or more of the specific details, or other methods, steps, etc. may be employed. In other instances, well-known methods, implementations, or operations are not shown or described in detail to avoid obscuring various aspects of this disclosure.

[0016] The flowcharts shown in the accompanying drawings are merely illustrative and do not necessarily include all content and operations / steps, nor do they necessarily have to be performed in the described order. For example, some operations / steps can be broken down, while others can be combined or partially combined; therefore, the actual execution order may change depending on the specific circumstances.

[0017] Please refer to Figure 1 and Figure 2 This invention proposes a method for preparing a fabric composition containing Centella asiatica, the steps of which include: S1. Add Centella asiatica raw material powder to an ethanol aqueous solution for extraction to obtain Centella asiatica extract. Separate the Centella asiatica extract into segments to obtain a first Centella asiatica component and a second Centella asiatica component. The first Centella asiatica component includes phenolic acids, flavonoids and polyphenolic substances, and the second Centella asiatica component includes asiaticoside, hydroxyasiaticoside, asiaticoside and hydroxyasiaticoside.

[0018] Step S1 includes: S1.1 Add Centella asiatica raw material powder to an ethanol aqueous solution with a volume fraction of 45% to 55%, the mass-volume ratio of Centella asiatica raw material powder to ethanol aqueous solution is 1g: (8 to 15)mL, continue to add pH buffer to adjust the pH value to 5.0 to 6.0, stir and pre-swell at 35℃ to 45℃ for 20min to 40min to obtain Centella asiatica mixture; S1.2. The Centella asiatica mixture is extracted by leaching and filtered to obtain Centella asiatica extract. The Centella asiatica extract is then concentrated under low temperature vacuum at a temperature of 35℃~45℃ and a vacuum degree of -0.06MPa~-0.09MPa until the ethanol volume fraction is no higher than 20% to obtain Centella asiatica concentrate. In step S1.2, the step of leaching and filtering the Centella asiatica mixture to obtain Centella asiatica extract includes: The Centella asiatica mixture was subjected to ultrasonic-assisted extraction with an ultrasonic power of 200W to 600W, a stirring speed of 100rpm to 300rpm, an extraction temperature of 40℃ to 55℃, and an extraction time of 30min to 90min. After extraction, the mixture was filtered to obtain the first-stage extract and Centella asiatica residue. The Centella asiatica filter residue was added to an ethanol aqueous solution with a volume fraction of 65%–80%, and the mass-volume ratio of Centella asiatica filter residue to ethanol aqueous solution was 1 g: (6–12) mL. The second stage of extraction was carried out under light-proof or nitrogen-protected conditions. The extraction temperature was 50℃–65℃, the stirring speed was 100 rpm–250 rpm, and the extraction time was 1 h–3 h. After the extraction was completed, the solution was filtered to obtain the second stage extract. The first-stage extract and the second-stage extract were mixed and centrifuged and finely filtered. The centrifugation speed was 4000 rpm to 8000 rpm and the centrifugation time was 10 min to 20 min. The fine filtration was carried out using a 0.45 μm to 1.0 μm microporous membrane to obtain the Centella asiatica extract.

[0019] S1.3. The Centella asiatica concentrate was loaded onto a polyamide resin column for the first stage of separation. The loading flow rate was 0.5 BV / h to 2 BV / h. After loading, purified water was used for elution, followed by desorption and elution with an ethanol aqueous solution with a volume fraction of 35% to 55%. The desorbed eluent was collected to obtain the first Centella asiatica fraction. S1.4. The effluent from the polyamide resin column is mixed with a 10%–20% (v / v) ethanol aqueous solution and then loaded onto a macroporous adsorption resin column for the second stage separation. The loading flow rate is 0.5 BV / h–1.5 BV / h. After loading, elution is performed using a 20%–35% (v / v) ethanol aqueous solution, followed by desorption elution using a 65%–85% (v / v) ethanol aqueous solution. The desorbed eluent is collected to obtain the second Centella asiatica component, which includes asiaticoside, hydroxyasiaticoside, asiaticoside, and hydroxyasiaticoside. S1.5. The first and second Centella asiatica components were freeze-dried respectively. During freeze-drying, the components were first pre-frozen at -40℃ for 4 to 8 hours, and then freeze-dried under vacuum for 24 to 36 hours.

[0020] The pH buffer solution includes at least one of citrate-sodium citrate buffer, acetic acid-sodium acetate buffer, lactate-sodium lactate buffer, sodium dihydrogen phosphate-disodium hydrogen phosphate buffer, and succinate-sodium succinate buffer, and the macroporous adsorption resin includes one of D101 type macroporous resin, AB-8 type macroporous resin, and HPD type macroporous resin.

[0021] Step S1 is used to extract and separate active components with different functional tendencies from Centella asiatica raw materials. The Centella asiatica raw material powder can be obtained by washing, drying, pulverizing, and sieving the whole plant, aerial parts, or leaf and stem parts of Centella asiatica. An ethanol-water solution is used to leach and extract the effective components from Centella asiatica, transferring phenolic acids, flavonoids, polyphenols, triterpenoid glycosides, and triterpenoid acids from the plant tissue to the liquid extraction medium. The first and second Centella asiatica components are not single pure compounds, but rather enriched fractions obtained through fractional separation; the first Centella asiatica component is mainly composed of phenolic acids, flavonoids, and polyphenols, while the second Centella asiatica component is mainly composed of asiaticoside, hydroxyasiaticoside, asiaticopic acid, and hydroxyasiaticopic acid.

[0022] In step S1.1, the Centella asiatica raw material powder is pre-swelled with an ethanol aqueous solution of 45%–55% (v / v), and the pH value is controlled at 5.0–6.0. ​​A moderate concentration of ethanol aqueous solution can accommodate the dissolution of both hydrophilic and moderately polar components, while the weakly acidic environment helps reduce the oxidation of polyphenols and the degradation of triterpenoid glycosides. Pre-swelling by stirring at 35℃–45℃ for 20–40 minutes allows the Centella asiatica powder to fully absorb the liquid and swell, improving the uniformity of subsequent leaching and extraction. The pH buffer can be selected from at least one of citrate-sodium citrate buffer, acetate-sodium acetate buffer, lactate-sodium lactate buffer, sodium dihydrogen phosphate-disodium hydrogen phosphate buffer, and succinate-sodium succinate buffer.

[0023] In step S1.2, the Centella asiatica mixture is first subjected to ultrasound-assisted extraction. Ultrasound treatment promotes the loosening of plant tissues through cavitation and mechanical disturbance, making it easier for active ingredients to dissolve. The first stage extraction uses a 45%–55% ethanol aqueous solution, which mainly facilitates the release of phenolic acids, flavonoids, and polyphenols. The second stage extraction uses a 65%–80% ethanol aqueous solution, which mainly facilitates the further dissolution of triterpenoids such as asiaticoside, hydroxyasiaticoside, asiatic acid, and hydroxyasiatic acid. The second stage extraction is protected from light or by nitrogen to reduce the impact of oxygen and light on the plant's active ingredients.

[0024] The first and second stage extracts were mixed and then centrifuged and filtered through a microporous membrane to remove plant fiber fragments, colloidal precipitates, and insoluble particles, yielding a Centella asiatica extract. This extract was then concentrated under low-temperature vacuum conditions at 35℃–45℃ and a vacuum of -0.06MPa–-0.09MPa, reducing the ethanol volume fraction to no more than 20% to obtain a concentrated Centella asiatica solution. This treatment reduces the adverse effects of high temperatures on the active ingredients and lowers the risk of column blockage and elution tailing during subsequent resin column separation.

[0025] In step S1.3, the Centella asiatica concentrate is fed into a polyamide resin column for the first stage of separation. Polyamide resin contains amide groups, which can form hydrogen bonds and polar adsorption with the phenolic hydroxyl and carboxyl groups in phenolic acids, flavonoids, and polyphenols, making it suitable for enriching these components. After loading, the sample is first washed with purified water to remove sugars, small molecule salts, and strongly hydrophilic impurities, and then eluted with a 35%–55% ethanol aqueous solution. The eluent is collected to obtain the first Centella asiatica fraction. The polyamide resin column can be a polyamide hexapolymer column, a polyamide hexachlorocyclohexapolymer column, a cross-linked polyamide resin column, a neutral polyamide resin column, or a pharmaceutical-grade column chromatography polyamide resin column.

[0026] In step S1.4, the effluent from the polyamide resin column and the 10%–20% ethanol aqueous solution eluent enter a macroporous adsorption resin column for the second stage of separation. Macroporous adsorption resins primarily rely on hydrophobic interactions, van der Waals forces, and pore size selectivity to adsorb triterpenoid glycosides and triterpenoid acids, making them suitable for enriching asiaticoside, hydroxyasiaticoside, asiaticopic acid, and hydroxyasiaticopic acid. After sample loading, residual highly polar impurities and weakly adsorbed components are first washed away with a 20%–35% ethanol aqueous solution, followed by desorption and elution with a 65%–85% ethanol aqueous solution. The desorbed eluent is collected to obtain the second Centella asiatica fraction. The macroporous adsorption resin can be a D101 type macroporous resin, an AB-8 type macroporous resin, or an HPD type macroporous resin.

[0027] In step S1.5, the first and second Centella asiatica components are freeze-dried respectively. Pre-freezing at -40°C for 4-8 hours, followed by freeze-drying under vacuum for 24-36 hours, removes moisture at low temperatures, reduces the risk of thermal degradation of phenolic acids, flavonoids, polyphenols, and triterpenoids during drying, and facilitates subsequent weighing, storage, and feeding.

[0028] Through the above steps, the active ingredients in Centella asiatica raw material are first extracted with a two-stage ethanol-water solution, and then continuously enriched in segments using a polyamide resin column and a macroporous adsorption resin column to obtain a first Centella asiatica component mainly composed of phenolic acids, flavonoids, and polyphenols, and a second Centella asiatica component mainly composed of asiaticoside, hydroxyasiaticoside, asiaticopic acid, and hydroxyasiaticopic acid. This method allows the first Centella asiatica component to be used in subsequent antibacterial fixation fabrics, and the second Centella asiatica component to be used in subsequent repair-promoting hydrogels, avoiding the problems of unclear component distribution and unclear functional layer effects caused by directly using crude Centella asiatica extract.

[0029] In one embodiment, step S1.2 involves a further separation step of the Centella asiatica extract.

[0030] Before low-temperature vacuum concentration of Centella asiatica extract, petroleum ether or n-hexane is added to the Centella asiatica extract for liquid-liquid extraction. After standing and separating the layers, the organic phase is discarded, and the ethanol-water phase is retained. The ethanol-water phase is then centrifuged and filtered. First, it is filtered through a 1.0 μm microporous membrane, and then through a 0.45 μm microporous membrane to obtain purified Centella asiatica extract.

[0031] S2. The second Centella asiatica component is added to a gelatin solution containing surfactant for dispersion and encapsulation to obtain Centella asiatica repair-promoting microparticles. Then, the Centella asiatica repair-promoting microparticles are added to a composite hydrogel solution for cross-linking to obtain Centella asiatica repair-promoting hydrogel.

[0032] Please refer to Figure 3 Step S2 includes: S2.1 Add gelatin to purified water and stir to dissolve at 45℃~55℃, with a stirring speed of 200rpm~500rpm and a dissolution time of 30min~60min, to obtain a gelatin solution with a mass fraction of 3%~8%. Then add a surfactant to the gelatin solution, with the amount of surfactant added being 0.05%~0.5% of the mass of the gelatin solution, and continue stirring for 10min~30min to obtain a gelatin solution containing surfactant. S2.2 Add the second Centella asiatica component to a gelatin solution containing a surfactant. The mass ratio of the second Centella asiatica component to the gelatin is 1:(5-30). Perform high-speed shear dispersion at 40℃-50℃, with a shearing speed of 6000rpm-12000rpm and a shearing time of 5min-15min. Then perform ultrasonic dispersion with an ultrasonic power of 100W-300W and an ultrasonic time of 3min-10min to obtain the second Centella asiatica gelatin dispersion. S2.3. Add a mild crosslinking agent to the second Centella asiatica gelatin dispersion for pre-crosslinking treatment. The amount of mild crosslinking agent added is 0.02% to 0.3% of the gelatin mass, the crosslinking temperature is 25℃ to 37℃, and the crosslinking time is 30 min to 3 h to obtain a pre-crosslinked gelatin-loaded liquid. The pre-crosslinked gelatin-loaded liquid is then granulated into microparticles by spray granulation. The nozzle orifice diameter of the granulation equipment is 50 μm to 300 μm, the feed flow rate is 0.2 mL / min to 2 mL / min, the receiving liquid temperature is 4℃ to 15℃, and after collection, it is further cured for 30 min to 120 min to obtain Centella asiatica repair-promoting microparticles. S2.4 Centrifugal washing and particle size sieving of Centrifugal repair-promoting microparticles. Centrifugation speed is 3000rpm~6000rpm, centrifugation time is 5min~15min, washing solution is phosphate buffer with pH value of 6.0~7.0, and after washing 2~3 times, Centrifugal repair-promoting microparticles with particle size of 10μm~200μm are collected. S2.5 The composite hydrogel liquid includes sodium alginate. Centella asiatica repair-promoting microparticles are added to the composite hydrogel liquid, and then calcium ion crosslinking liquid is added for crosslinking. After crosslinking is completed, it is stabilized at 4℃~10℃ for 2h~8h to obtain Centella asiatica repair-promoting hydrogel.

[0033] Step S2.5 includes: Oxidized hyaluronic acid was dissolved in purified water to obtain an oxidized hyaluronic acid solution with a mass fraction of 0.5% to 2.0%. Carboxymethyl chitosan and sodium alginate were dissolved in purified water to obtain a carboxymethyl chitosan-sodium alginate composite solution with a mass fraction of 1% to 3% for carboxymethyl chitosan and a mass fraction of 0.5% to 2% for sodium alginate. Moisturizing and repairing components and ion regulating components were then added and stirred evenly to obtain a composite hydrogel precursor solution. Centella asiatica repair-promoting microparticles were added to the composite hydrogel precursor solution for low-speed dispersion. The amount of Centella asiatica repair-promoting microparticles added was 1% to 10% of the mass of the composite hydrogel precursor solution. The dispersion temperature was 20℃ to 30℃, the stirring speed was 80 rpm to 200 rpm, and the dispersion time was 10 min to 30 min to obtain the hydrogel premix. Oxidized hyaluronic acid solution was added to the hydrogel premix for cross-linking. The mixing temperature was 20℃~30℃, the mixing time was 3min~15min, and the pH value was controlled at 6.0~7.2 to obtain a preliminary cross-linked hydrogel. A calcium ion crosslinking solution was added dropwise to the initially crosslinked hydrogel for secondary crosslinking. The amount of calcium ion crosslinking solution added was 1% to 8% of the mass of the initially crosslinked hydrogel. The crosslinking temperature was 20℃ to 30℃, and the crosslinking time was 10 min to 60 min. After the crosslinking was completed, the temperature was lowered to 4℃ to 10℃ and maintained for 2 h to 8 h to obtain the Centella Asiatica repair-promoting hydrogel.

[0034] The surfactant includes at least one of poloxamer, polysorbate, and lecithin; the mild crosslinking agent includes at least one of genipin and tannic acid; the moisturizing and repairing component includes at least one of sodium hyaluronate, β-glucan, allantoin, and panthenol; the ion regulating component includes at least one of zinc gluconate, zinc lactate, zinc acetate, magnesium chloride, magnesium lactate, and sodium chloride; and the calcium ion crosslinking solution is one of calcium chloride solution, calcium lactate solution, and calcium gluconate solution with a mass fraction of 0.05% to 0.5%.

[0035] Step S2 involves preparing the second Centella asiatica component into Centella asiatica repair-promoting microparticles, which are then further dispersed and fixed in a composite hydrogel to obtain the Centella asiatica repair-promoting hydrogel. The second Centella asiatica component mainly includes asiaticoside, asiaticoside, asiaticopic acid, and asiaticopic acid. Some of the triterpenoid acid components exhibit poor dispersibility in the aqueous system; if directly added to the hydrogel, they are prone to aggregation, precipitation, or uneven release. Therefore, this step first uses a gelatin solution containing surfactants for dispersion and encapsulation, and then adds the formed repair-promoting microparticles to the composite hydrogel for cross-linking and molding.

[0036] In step S2.1, gelatin serves as the carrier matrix for the second Centella asiatica component. Gelatin possesses hydrophilicity and gelling properties, enabling it to form microparticle structures under mild conditions. Controlling the gelatin mass fraction to 3%–8% allows the gelatin solution to simultaneously exhibit good flowability and moldability. Surfactants, including at least one of poloxamer, polysorbate, and lecithin, are used to reduce the interfacial tension between the second Centella asiatica component and the aqueous gelatin phase, allowing relatively hydrophobic components such as asiatic acid and hydroxyasiatic acid to be more uniformly dispersed in the gelatin solution. The amount of surfactant added is controlled at 0.05%–0.5% of the gelatin solution mass, primarily serving a dispersing and stabilizing role, avoiding excessive amounts that could negatively impact subsequent microparticle formation and hydrogel stability.

[0037] In step S2.2, the second Centella asiatica component is uniformly incorporated into the gelatin solution through high-speed shear dispersion and ultrasonic dispersion. High-speed shearing is used to break up agglomerates, and ultrasonic dispersion is used to further improve the dispersion of fine particles and hydrophobic components. The mass ratio of the second Centella asiatica component to gelatin is controlled at 1:(5-30) to ensure that the gelatin has sufficient encapsulation capacity for the second Centella asiatica component and to reduce the initial rapid release caused by excessive free active ingredients.

[0038] In step S2.3, a mild crosslinking agent is used to form a pre-crosslinked structure in the gelatin. The mild crosslinking agent includes at least one of genipin and tannic acid. Genipin can crosslink with the amino groups in the gelatin, and tannic acid can form multiple hydrogen bonds with the gelatin and the second Centella asiatica component. Mild crosslinking at 25°C–37°C for 30 min–3 h improves the molding stability of the gelatin-encapsulated liquid while reducing the adverse effects of high temperatures or strong reaction conditions on the second Centella asiatica component. Subsequently, spray granulation is used to form the second Centella asiatica component in the form of gelatin microparticles, yielding Centella asiatica repair-promoting microparticles.

[0039] In step S2.4, the Centella Asiatica repair-promoting microparticles are subjected to centrifugal washing and particle size sieving. Centrifugal washing removes free second Centella Asiatica component, residual surfactants, and unbound small molecules; washing with a phosphate buffer solution with a pH of 6.0–7.0 keeps the microparticles in a relatively mild environment. Collecting Centella Asiatica repair-promoting microparticles with a particle size of 10 μm–200 μm balances the uniformity of dispersion in the hydrogel and the stability of microparticle encapsulation, avoiding the impact of excessively large particle size on the smoothness of the hydrogel, and also avoiding excessively small particle size leading to too rapid release.

[0040] In step S2.5, the composite hydrogel solution is used to form a wound contact layer. The composite hydrogel solution preferably includes oxidized hyaluronic acid, carboxymethyl chitosan, and sodium alginate. The aldehyde groups in oxidized hyaluronic acid can form Schiff base dynamic crosslinks with the amino groups in carboxymethyl chitosan, and sodium alginate can form ionic crosslinks with calcium ions in the calcium ion crosslinking solution. Through these two types of crosslinking, a composite hydrogel network with wet-state stability can be formed.

[0041] The moisturizing and repairing components include at least one of sodium hyaluronate, β-glucan, allantoin, and panthenol, used to improve the moisturizing properties of the hydrogel and its wound adhesion environment. The ion-regulating components include at least one of zinc gluconate, zinc lactate, zinc acetate, magnesium chloride, magnesium lactate, and sodium chloride, used to regulate the ionic environment of the hydrogel system. The calcium ion crosslinking solution is a 0.05%–0.5% (w / w) calcium chloride solution, calcium lactate solution, or calcium gluconate solution, which mainly undergoes ion crosslinking with sodium alginate to improve the wet strength and liquid retention capacity of the hydrogel.

[0042] In step S2, the second Centella asiatica component is first dispersed with the aid of surfactant, then encapsulated in gelatin to form repair-promoting microparticles, and finally fixed in the composite hydrogel network. This method can improve the uniformity of the distribution of the second Centella asiatica component in the hydrogel, reduce agglomeration and rapid initial loss caused by direct addition to the hydrogel, and make the hydrogel suitable as a repair-promoting contact layer for subsequent medical dressings.

[0043] S3. The first Centella asiatica component and the antibacterial spinning solution are mixed and then spun to obtain the Centella asiatica antibacterial fixing fabric. Then, the Centella asiatica repair-promoting hydrogel, the Centella asiatica antibacterial fixing fabric, and the composite breathable fabric are compounded in sequence to obtain a fabric composition containing Centella asiatica components. The antibacterial spinning solution includes antibacterial components and spinning components.

[0044] Please refer to Figure 4 Step S3 includes: S3.1 Add the spinning component to an organic solvent and stir to dissolve it at 25℃~45℃, with a stirring speed of 200rpm~600rpm and a stirring time of 2h~6h to obtain the spinning base solution. Add the antibacterial component and the interface fixing component to the spinning base solution and stir to disperse it at 20℃~35℃, with a stirring speed of 200rpm~600rpm and a stirring time of 30min~90min. Then perform vacuum degassing treatment to obtain the antibacterial spinning solution. The interface fixing component includes phytic acid or citric acid. S3.2 Add the first Centella asiatica component to the antibacterial spinning solution. The mass ratio of the first Centella asiatica component to the spinning component is 1:(10-50). Disperse the mixture at low speed under the conditions of 20℃-35℃, with a stirring speed of 100rpm-300rpm and a stirring time of 20min-60min to obtain the Centella asiatica antibacterial spinning solution. S3.3 Add the Centella asiatica antibacterial spinning solution to an electrostatic spinning device for spinning treatment. The spinning voltage is 12kV~25kV, the feed speed is 0.2mL / h~1.5mL / h, the distance between the nozzle and the receiving device is 10cm~20cm, the ambient temperature is 20℃~30℃, the ambient relative humidity is 30%~55%, and the spinning time is 0.5h~4h to obtain Centella asiatica antibacterial fixed nascent fabric. S3.4 Cross-linking and curing treatment is carried out on the Centella asiatica antibacterial fixation nascent fabric. When the interface fixing component is citric acid, heat treatment is carried out at 80℃~120℃ for 3min~15min. When the interface fixing component is phytic acid, drying is carried out at 25℃~45℃ for 30min~120min. Then, it is rinsed with purified water 1~3 times and then vacuum dried at 25℃~40℃ for 2h~6h to obtain the Centella asiatica antibacterial fixation fabric. S3.5. Medical nonwoven fabric and polymer microporous membrane are hot-pressed together at a temperature of 40℃~80℃ and a pressure of 0.05MPa~0.3MPa to obtain a composite breathable fabric. Centella asiatica repair-promoting hydrogel is coated onto a release film with a coating thickness of 0.5mm~3mm. Then, Centella asiatica antibacterial fixing fabric is placed over the side of the Centella asiatica repair-promoting hydrogel away from the release film. The interface is wetted and bonded at 20℃~30℃, and the composite is performed using a roller pressing equipment at a pressure of 0.02MPa~0.15MPa and a speed of 0.1m / min~1m / min to obtain a hydrogel antibacterial fixing fabric composite layer. S3.6. The composite breathable fabric is covered on the side of the Centella asiatica antibacterial fixing fabric away from the Centella asiatica repair-promoting hydrogel, and the composite is performed by dotting and pressing. The composite temperature is 35℃~65℃, the composite pressure is 0.02MPa~0.2MPa, and the composite time is 5s~60s to obtain a wet composite preform of fabric composition containing Centella asiatica. S3.7. Stabilize the wet composite preform of the fabric composition containing Centella asiatica at 4℃~10℃ for 2h~8h, and then cut, inspect, sterilize and seal the packaging to obtain the fabric composition containing Centella asiatica.

[0045] The spinning component includes at least one of silk fibroin, chitosan, and polyvinyl alcohol; the organic solvent includes at least one of aqueous ethanol solution, aqueous acetic acid solution, and hexafluoroisopropanol; the antibacterial component includes at least one of chitosan quaternary ammonium salt, nano zinc oxide, and silver ion antibacterial agent; the polymer microporous membrane includes polyurethane microporous membrane or polyethylene microporous membrane; and the sterilization method includes at least one of ethylene oxide sterilization, low-dose irradiation sterilization, or aseptic preparation followed by sealed packaging.

[0046] Step S3 is used to prepare the Centella Asiatica antibacterial fixation fabric, and to combine the Centella Asiatica repair-promoting hydrogel, the Centella Asiatica antibacterial fixation fabric, and the composite breathable fabric into a fabric composition containing Centella Asiatica components. The fabric composition refers to a multi-layer composite material formed by a hydrogel layer, an antibacterial fiber layer, and a breathable and antibacterial outer layer, wherein the Centella Asiatica repair-promoting hydrogel is used as a moist contact layer close to the wound surface, the Centella Asiatica antibacterial fixation fabric is used to load the first Centella Asiatica component and provide an antibacterial fixation structure, and the composite breathable fabric is used to provide lateral support, breathability, and barrier against contaminants.

[0047] In step S3.1, the spinning component is used to form the fiber matrix of the Centella asiatica antibacterial fixation fabric. The spinning component includes at least one of silk fibroin, chitosan, and polyvinyl alcohol. Silk fibroin possesses flexibility and skin-friendliness, chitosan has film-forming properties and a certain degree of antibacterial auxiliary effect, and polyvinyl alcohol is beneficial for improving the continuous fiber-forming performance of the spinning solution. An organic solvent is used to dissolve or disperse the spinning component and may include at least one of aqueous ethanol solution, aqueous acetic acid solution, and hexafluoroisopropanol. In practice, the organic solvent should be selected according to the spinning component; for example, chitosan can be treated with an aqueous acetic acid solution, silk fibroin can be treated with hexafluoroisopropanol or a suitable aqueous solvent, and polyvinyl alcohol can be treated with an aqueous or ethanol-water system.

[0048] The antibacterial component, used to enhance the antibacterial ability of the Centella asiatica antibacterial fixation fabric, may include at least one of chitosan quaternary ammonium salt, nano-zinc oxide, and silver ion antibacterial agents. The interface fixation component, including phytic acid or citric acid, is used to improve the retention stability of the first Centella asiatica component in the fiber matrix. Citric acid contains carboxyl groups, which can undergo esterification, amidation, or hydrogen bonding with hydroxyl or amino groups in the fiber matrix; phytic acid contains multiple phosphate groups, which can form ionic interactions with chitosan-like cationic groups. By adding the interface fixation component, the rapid loss of the first Centella asiatica component under the influence of wound exudate can be reduced.

[0049] In step S3.2, the first Centella asiatica component is added to the antibacterial spinning solution to obtain a Centella asiatica antibacterial spinning solution. The first Centella asiatica component includes phenolic acids, flavonoids, and polyphenols, which are suitable for placement in antibacterial fixing fabrics to form an antioxidant and antibacterial auxiliary functional layer. The mass ratio of the first Centella asiatica component to the spinning component is controlled at 1:(10-50), which ensures the loading of active components while avoiding excessive first Centella asiatica component that could lead to abnormal viscosity of the spinning solution, nozzle clogging, or unstable fiber formation. Low-speed stirring and dispersion allows the first Centella asiatica component to enter the spinning system uniformly and reduces the instability of active component dispersion caused by strong shear.

[0050] In step S3.3, the Centella asiatica antibacterial spinning solution is spun using an electrospinning device to obtain a Centella asiatica antibacterial fixed nascent fabric. Electrospinning can form a porous fiber structure, allowing the first Centella asiatica component to be distributed within the fiber or on the fiber surface. Spinning voltage, feed speed, nozzle distance, ambient temperature, and humidity collectively affect fiber diameter, fiber continuity, and fabric pore structure. By controlling these parameters, a more uniform antibacterial fiber fabric can be obtained, providing a foundation for subsequent cross-linking curing and interlayer lamination.

[0051] In step S3.4, the Centella asiatica antibacterial fixation nascent fabric undergoes cross-linking and curing treatment. When the interfacial fixing component is citric acid, heat treatment at 80℃~120℃ can promote the formation and binding of citric acid with hydroxyl or amino groups in the fiber matrix, improving the fixation stability of the first Centella asiatica component in the fabric. When the interfacial fixing component is phytic acid, drying treatment at 25℃~45℃ can allow phytic acid to form ionic interactions with chitosan or other amino-containing materials. Subsequently, rinsing with purified water and vacuum drying can remove unfixed small molecules, residual solvents, and unbound components, reducing the risk of free residues when subsequently applied to the wound.

[0052] In step S3.5, medical nonwoven fabric and polymer microporous membrane are hot-pressed together to form a composite breathable fabric. The medical nonwoven fabric provides flexible support and operational strength, while the polymer microporous membrane provides breathability and barrier properties against external pollutants. The polymer microporous membrane can be a polyurethane microporous membrane or a polyethylene microporous membrane. After coating the Centella Asiatica repair-promoting hydrogel onto the release film and covering it with a Centella Asiatica antibacterial fixing fabric, interface wetting bonding and roll pressing are performed. This allows the hydrogel to penetrate the pores of the fiber fabric surface, forming a more stable interlayer bond and reducing the separation of the hydrogel layer from the fiber layer during use.

[0053] In step S3.6, the composite breathable fabric is applied over the outer side of the Centella Asiatica antibacterial fixing fabric and bonded together using a dot-adhesive pressing method. Dot-adhesive pressing can maintain the composite strength while reducing the obstruction of the breathable pores by the adhesive, thus avoiding affecting the breathability of the composite breathable fabric. Controlling the bonding temperature, pressure, and time within a low range can reduce problems such as hydrogel water loss, fiber fabric deformation, or thermal instability of the Centella Asiatica active components.

[0054] In step S3.7, the wet composite preform undergoes low-temperature stabilization treatment, followed by cutting, inspection, sterilization, and sealing packaging. Stabilization treatment at 4℃ to 10℃ helps further stabilize the interface between the hydrogel layer, the antibacterial fixing fabric, and the composite breathable fabric, reducing interlayer displacement after lamination. Sterilization methods can include ethylene oxide sterilization, low-dose irradiation sterilization, or aseptic preparation followed by sealing packaging. Different sterilization methods can be selected based on material tolerance and the stability of the active components.

[0055] In step S3, the first Centella asiatica component is introduced into the antibacterial spinning system, and through spinning and cross-linking curing, a Centella asiatica antibacterial fixing fabric is formed. This fabric is then combined with a Centella asiatica repair-promoting hydrogel and a composite breathable fabric to form a multilayer fabric composition with a hydrogel contact layer, an antibacterial fixing layer, and a breathable outer layer. This structure allows the first Centella asiatica component to be mainly distributed in the antibacterial fixing fabric, and the second Centella asiatica component to be mainly distributed in the repair-promoting hydrogel, thus avoiding the problem of unclear functional layers caused by direct mixing.

[0056] This invention proposes a fabric composition containing Centella asiatica, which is prepared by a method for making a fabric composition containing Centella asiatica.

[0057] Example 1: This embodiment prepares a fabric composition containing Centella asiatica. 100g of Centella asiatica raw material powder was added to 1000mL of 50% (v / v) ethanol aqueous solution, and citrate-sodium citrate buffer was added to adjust the pH to 5.5. The mixture was stirred at 200rpm for 30min at 40℃ to pre-swell, obtaining a Centella asiatica mixture. Subsequently, the Centella asiatica mixture was subjected to ultrasonic-assisted extraction at 400W, stirring speed of 200rpm, extraction temperature of 50℃, and extraction time of 60min. After filtration, the first-stage extract and Centella asiatica residue were obtained. The Centella asiatica residue was added to 800mL of 75% (v / v) ethanol aqueous solution, and a second-stage extraction was performed under nitrogen protection at 60℃, stirring speed of 150rpm, and extraction time of 2h. After filtration, the second-stage extract was obtained. The first-stage extract and the second-stage extract were mixed, centrifuged at 6000rpm for 15min, and then filtered through a 0.45μm microporous membrane to obtain the Centella asiatica extract. Centella asiatica extract was concentrated under low temperature vacuum at 40℃ and -0.08MPa until the ethanol volume fraction was no higher than 20%, thus obtaining Centella asiatica concentrate.

[0058] The concentrated Centella asiatica extract was loaded onto a polyamide resin column for the first stage of separation at a flow rate of 1 BV / h. After loading, the sample was eluted with purified water, followed by low-concentration elution with a 15% (v / v) ethanol aqueous solution, and then desorbed and eluted with a 45% (v / v) ethanol aqueous solution. The 45% ethanol aqueous solution eluent was collected to obtain the first Centella asiatica fraction. The effluent from the polyamide resin column and the 15% ethanol aqueous solution eluent were mixed and loaded onto a D101 macroporous adsorption resin column for the second stage of separation at a flow rate of 1 BV / h. After loading, the sample was eluted with a 30% (v / v) ethanol aqueous solution, followed by desorbed and eluted with a 75% (v / v) ethanol aqueous solution. The 75% ethanol aqueous solution eluent was collected to obtain the second Centella asiatica fraction. The first and second Centella asiatica components were freeze-dried separately. They were first pre-frozen at -40℃ for 6 hours and then freeze-dried under vacuum for 30 hours to obtain 4.6 g of freeze-dried first Centella asiatica component and 3.1 g of freeze-dried second Centella asiatica component.

[0059] 10g of gelatin was added to 190g of purified water and stirred at 350rpm for 45min at 50℃ to obtain a 5% gelatin solution. Then, 0.4g of poloxamer was added to the gelatin solution, and stirring continued for 20min to obtain a gelatin solution containing a surfactant. 1.0g of the second *Centella asiatica* component was added to the surfactant-containing gelatin solution, with a mass ratio of 1:10. High-speed shear dispersion was performed at 45℃, with a shear speed of 9000rpm and a shear time of 10min. Following this, ultrasonic dispersion was performed at a power of 200W for 6min to obtain a *Centella asiatica* gelatin dispersion. 0.01g of genipin was added to the second *Centella asiatica* gelatin dispersion for pre-crosslinking treatment at 32℃ for 1.5h to obtain a pre-crosslinked gelatin-loaded solution. The pre-crosslinked gelatin-loaded solution was granulated into microparticles via spray granulation. The nozzle orifice diameter was 150 μm, the feed flow rate was 1.0 mL / min, and the receiving liquid temperature was 8 °C. After collection, the microparticles were further cured for 60 min to obtain Centella asiatica repair-promoting microparticles. The microparticles were centrifuged at 4500 rpm for 10 min, washed three times with phosphate buffer (pH 6.8), and the microparticles with a particle size of 10 μm to 200 μm were collected by sieving.

[0060] 1.0 g of oxidized hyaluronic acid was dissolved in 99 g of purified water to obtain a 1.0% (w / w) oxidized hyaluronic acid solution. 2.0 g of carboxymethyl chitosan and 1.0 g of sodium alginate were dissolved in 97 g of purified water to obtain a carboxymethyl chitosan-sodium alginate composite solution; then 0.3 g of sodium hyaluronate and 0.1 g of zinc gluconate were added, and the mixture was stirred until homogeneous to obtain a composite hydrogel precursor solution. 5 g of Centella asiatica repair-promoting microparticles were added to 95 g of the composite hydrogel precursor solution, and the mixture was stirred at 120 rpm for 20 min at 25 °C to obtain a hydrogel premix. The oxidized hyaluronic acid solution was added to the hydrogel premix, and the mixing temperature was 25 °C for 10 min, with the pH controlled at 6.8, to obtain a preliminary cross-linked hydrogel. A 0.2% (w / w) calcium chloride solution was added dropwise to the initially cross-linked hydrogel. The amount of calcium chloride solution added was 5% of the mass of the initially cross-linked hydrogel. Cross-linking was carried out at 25℃ for 30 min. After cross-linking was completed, the temperature was lowered to 8℃ and maintained for 4 h to obtain the Centella Asiatica repair-promoting hydrogel.

[0061] 5g of polyvinyl alcohol and 2g of chitosan were added to 93g of acetic acid aqueous solution and stirred at 400rpm for 4h at 40℃ to obtain the spinning base solution. 1g of chitosan quaternary ammonium salt and 0.3g of phytic acid were added to the spinning base solution and stirred at 400rpm for 60min at 25℃, followed by vacuum degassing to obtain the antibacterial spinning solution. 0.5g of the first Centella asiatica component was added to the antibacterial spinning solution, with a mass ratio of 1:14 between the first Centella asiatica component and the spinning component. The mixture was stirred at 200rpm for 40min at 25℃ to obtain the Centella asiatica antibacterial spinning solution. The Centella asiatica antibacterial spinning solution was then spun in an electrostatic spinning device at a spinning voltage of 18kV, a feed speed of 0.8mL / h, a distance of 15cm between the nozzle and the receiving device, an ambient temperature of 25℃, a relative humidity of 45%, and a spinning time of 2h to obtain the Centella asiatica antibacterial fixed nascent fabric. The Centella asiatica antibacterial fixation nascent fabric was dried at 35℃ for 60 minutes, then rinsed twice with purified water, and vacuum dried at 35℃ for 4 hours to obtain the Centella asiatica antibacterial fixation fabric.

[0062] Medical nonwoven fabric and polyurethane microporous membrane were hot-pressed together at 60℃ and 0.15MPa to obtain a composite breathable fabric. Centella asiatica repair-promoting hydrogel was coated onto a release film to a thickness of 1.5mm. Then, a Centella asiatica antibacterial fixing fabric was placed over the side of the hydrogel facing away from the release film. Interface wetting and bonding were performed at 25℃ using a roller pressing device at a pressure of 0.08MPa and a speed of 0.5m / min to obtain a hydrogel antibacterial fixing fabric composite layer. The composite breathable fabric was then placed over the side of the Centella asiatica antibacterial fixing fabric away from the hydrogel and bonded together using a dot-adhesion pressing method at 50℃, a pressure of 0.1MPa, and a time of 30s to obtain a wet composite preform containing Centella asiatica. The wet composite preform was stabilized at 8°C for 4 hours, then cut, inspected, sterilized with ethylene oxide, and sealed and packaged to obtain a fabric composition containing Centella asiatica.

[0063] Example 2: The specific difference between this embodiment and Example 1 is that, before low-temperature vacuum concentration, the Centella asiatica extract is first defatted and impurities removed with hexane. The volume ratio of hexane to Centella asiatica extract is 1:3. After shaking for 10 minutes, the mixture is allowed to stand and separate into layers. The hexane phase is discarded, and the ethanol-water phase is retained. Subsequently, the ethanol-water phase is passed sequentially through a 1.0 μm microporous membrane, a 0.45 μm microporous membrane, and an ultrafiltration membrane with a molecular weight cutoff of 10000 Da. The permeate is collected and then concentrated under low-temperature vacuum. During polyamide resin column elution, after elution with purified water, 10% and 20% ethanol-water solutions are added for segmented elution. Then, 45% ethanol-water solution is used for desorption to obtain the first Centella asiatica fraction. Before entering the D101 macroporous adsorption resin column, the polyamide resin column effluent and the 10%–20% ethanol-water solution eluent are combined and the ethanol volume fraction is adjusted to 10%. Other steps and dosages are the same as in Example 1.

[0064] Example 3: The specific differences between this embodiment and Embodiment 2 are as follows: in step S2.1, the surfactant is a compound of 0.25g polysorbate and 0.15g lecithin; in step S2.3, the mild crosslinking agent is 0.015g tannic acid; in step S2.5, the moisturizing and repairing components are 0.25g sodium hyaluronate, 0.20g β-glucan, and 0.10g panthenol, the ion-regulating components are 0.08g zinc gluconate and 0.05g magnesium lactate, and the calcium ion crosslinking solution is a 0.2% calcium lactate solution, with the amount of calcium lactate solution added being 6% of the mass of the initially crosslinked hydrogel. Other steps and dosages are the same as in Embodiment 2.

[0065] Example 4: The specific differences between this embodiment and Embodiment 3 are as follows: In step S3.1, the spinning component uses 3g silk fibroin, 2g chitosan, and 5g polyvinyl alcohol; the antibacterial component uses 0.8g chitosan quaternary ammonium salt and 0.15g nano zinc oxide; and the interface fixation component uses 0.25g citric acid. In step S3.4, the Centella asiatica antibacterial fixation nascent fabric is heat-treated at 100℃ for 8 minutes, then rinsed twice with purified water, and vacuum-dried at 35℃ for 4 hours. In step S3.5, the polymer microporous membrane is a polyurethane microporous membrane, and the hydrogel coating thickness is 1.2mm. In step S3.6, the dispensing and pressing temperature is 45℃, the composite pressure is 0.08MPa, and the composite time is 25s. Other steps and dosages are the same as in Embodiment 3.

[0066] Example 5: Based on Example 4, in this embodiment, after obtaining the Centella asiatica antibacterial fixing fabric in step S3.4, the side of the Centella asiatica antibacterial fixing fabric used to contact the Centella asiatica repair-promoting hydrogel is used as the interface treatment side, and the other side is used as the composite breathable fabric connection side. An interface buffer locking solution is prepared, which includes 0.2% oxidized hyaluronic acid, 0.3% carboxymethyl chitosan, 0.1% sodium alginate, 0.05% sodium hyaluronate, and 0.05% sodium chloride. The pH value is adjusted to 6.5 using a lactic acid-sodium lactate buffer solution.

[0067] The interface buffering and locking liquid was sprayed onto the interface-treated side of the Centella asiatica antibacterial fixing fabric at a spraying amount of 6 g / m². 2 After standing and wetting for 20 minutes at 25℃~35℃, spray with a 0.05% calcium gluconate solution at a spraying rate of 3g / m². 2 The mixture was left to stand for 30 minutes, then vacuum dried at 40°C for 60 minutes to obtain the Centella asiatica antibacterial and fixing fabric treated with interface buffering and locking. Subsequently, following steps S3.5 to S3.7 of Example 4, the Centella asiatica repair-promoting hydrogel, the Centella asiatica antibacterial and fixing fabric treated with interface buffering and locking, and the composite breathable fabric were sequentially compounded to obtain a fabric composition containing Centella asiatica.

[0068] Comparative Example 1: The difference between this comparative example and Example 1 is that the Centella asiatica extract is not fractionated. Specifically, the Centella asiatica extract is concentrated under low-temperature vacuum and then directly freeze-dried to obtain the total Centella asiatica extract. The total Centella asiatica extract is then divided into two parts at a mass ratio of 1:1. One part replaces the first Centella asiatica component and is added to the antibacterial spinning solution, while the other part replaces the second Centella asiatica component and is added to a gelatin solution containing a surfactant. The remaining steps, amounts, and process conditions are the same as in Example 1.

[0069] Comparative Example 2: The difference between this comparative example and Example 1 is that no surfactant is added in step S2.1. Specifically, gelatin is dissolved in purified water to obtain a gelatin solution, and then the second Centella asiatica component is directly added to the gelatin solution for shear dispersion and ultrasonic dispersion. The remaining steps, amounts, and process conditions are the same as in Example 1.

[0070] Comparative Example 3: The difference between this comparative example and Example 1 is that Centella asiatica repair-promoting microparticles are not prepared. Specifically, steps S2.3 and S2.4 are omitted. The second Centella asiatica component is directly added to the composite hydrogel precursor solution for low-speed dispersion, and then oxidized hyaluronic acid solution and calcium ion crosslinking solution are added for crosslinking to obtain a hydrogel containing the second Centella asiatica component. The remaining steps, amounts, and process conditions are the same as in Example 1.

[0071] Comparative Example 4: The difference between this comparative example and Example 1 is that no interface fixing component is added in step S3.1. Specifically, only chitosan quaternary ammonium salt is added to the spinning base solution, and phytic acid or citric acid is not added. In step S3.4, no corresponding cross-linking and curing treatment is performed; only purified water rinsing and vacuum drying are used. The remaining steps, dosages, and process conditions are the same as in Example 1.

[0072] Experiment 1 Procedure: The loading rate of the second Centella asiatica component was detected by high performance liquid chromatography. The total amount of the second Centella asiatica component in the feed and the content of the free second Centella asiatica component in the washing liquid and supernatant were determined respectively. The loading was calculated based on the difference between the feed amount and the free amount.

[0073] The hydrogel's liquid absorption performance was determined using a gravimetric method. Samples were cut into 2cm × 2cm pieces, weighed initially, and then placed in a phosphate buffer solution with a pH of 7.4. The sample was soaked at 37°C for 2 hours. After removal, the surface was gently touched with filter paper to remove free liquid, and the mass after absorption was measured again. The mass of liquid absorbed per unit mass of sample was calculated. Water vapor transmission rate was determined using a cup method. The sample was fixed at the mouth of a test cup filled with purified water and placed at 37°C and 50% relative humidity for 24 hours. The water vapor transmission rate was calculated based on the change in the mass of the test cup.

[0074] Release performance was assessed using an in vitro release assay. Samples were placed in phosphate-buffered saline at 37°C, and samples were taken at 2h, 6h, 24h, and 72h, with equal volumes of fresh release medium added. The release amount of characteristic components in the second Centella asiatica fraction was detected using high-performance liquid chromatography (HPLC), and the cumulative release ratio was calculated. Cell compatibility was assessed using the fibroblast extract method. Samples were added to cell culture medium at a specified ratio to prepare an extract, which was then co-cultured with fibroblasts for 24h. The relative cell viability was assessed using the CCK-8 assay.

[0075] The experimental data for Experiment 1 are shown in Table 1. Since no Centella asiatica repair-promoting microparticles were prepared for Comparative Example 3, the loading rate of the second Centella asiatica component in Comparative Example 3 was not measured.

[0076] Table 1: The experimental data from Experiment 1 show that the fabric compositions containing Centella asiatica in Examples 1-5 all exhibited good encapsulation capacity of the second Centella asiatica component, hydrogel liquid absorption capacity, water vapor permeability, wet retention capacity of the first Centella asiatica component, sustained release performance of the second Centella asiatica component, and cell compatibility. This indicates that by utilizing the first and second Centella asiatica components in stages, encapsulating the second Centella asiatica component in gelatin, crosslinking the composite hydrogel, and fixing the first Centella asiatica component through spinning, a fabric composition with a stable structure and clearly defined functional layers can be obtained.

[0077] Compared to Example 1, Example 2 reduced the amount of lipid-soluble impurities, colloidal impurities, and macromolecular impurities in the Centella asiatica extract by adding defatting, microfiltration, ultrafiltration, and fractional elution steps. This facilitated the fractional enrichment of the first and second Centella asiatica components. As a result, the loading rate of the second Centella asiatica component, the wet retention rate of the first Centella asiatica component, and cell compatibility all showed an improved trend, indicating that pre-column purification and fractional elution can improve the application stability of the separated components.

[0078] Compared to Example 2, Example 3 improved the dispersion of the second Centella asiatica component in the gelatin solution and composite hydrogel system by using a combination of polysorbate and lecithin as surfactants and introducing components such as β-glucan, panthenol, zinc gluconate, and magnesium lactate. Simultaneously, the moisturizing properties and humid environment of the hydrogel contact layer were enhanced. Therefore, Example 3 showed superior performance in terms of second Centella asiatica component encapsulation, hydrogel absorption, sustained release, and cell compatibility, demonstrating that the surfactant combination and hydrogel auxiliary components can synergistically improve the performance of the repair-promoting hydrogel layer.

[0079] Compared to Example 3, Example 4 enhanced the fixation of the first Centella asiatica component in the fiber network by adjusting the spinning composition to a combination of silk fibroin, chitosan, and polyvinyl alcohol, and by using chitosan quaternary ammonium salt, nano-zinc oxide, and citric acid to construct an antibacterial fixation fabric. Experimental results showed that the wet retention capacity of the first Centella asiatica component in Example 4 was significantly improved, indicating that citric acid heat treatment crosslinking and the composite spinning matrix can reduce the loss of the first Centella asiatica component in a humid environment.

[0080] Compared to Example 4, Example 5 incorporates an interface buffering and locking treatment before the Centella asiatica antibacterial fixing fabric and the Centella asiatica repair-promoting hydrogel are composited. This treatment creates a transition interface between the two layers, consisting of oxidized hyaluronic acid, carboxymethyl chitosan, sodium alginate, sodium hyaluronate, sodium chloride, and calcium gluconate. This transition interface buffers the interaction between the interface fixing components in the antibacterial fixing fabric and the calcium ion crosslinking system of the hydrogel, and reduces the migration of the first Centella asiatica component after interlayer composite formation. Therefore, Example 5 maintains good performance in terms of wet retention of the first Centella asiatica component, hydrogel absorption, and cell compatibility, indicating that the interface buffering and locking treatment is beneficial for improving the interfacial stability of the multilayer fabric composition.

[0081] Comparative Example 1 did not perform fractional separation of the Centella asiatica extract; instead, the total Centella asiatica extract was used directly, resulting in unclear functional boundaries between the first and second Centella asiatica components. Experimental results showed that the encapsulation effect of the second Centella asiatica component, the wet retention capacity of the first Centella asiatica component, the sustained-release stability, and the cell compatibility were all relatively insufficient, indicating that fractional separation plays an important role in achieving the targeted utilization of different Centella asiatica components in different functional layers.

[0082] In Comparative Example 2, without the addition of surfactant, the dispersion compatibility of the second Centella asiatica component in the gelatin solution decreased, leading to a reduction in particle loading capacity and making the initial concentrated release of the second Centella asiatica component more likely. This result indicates that surfactants can improve the interfacial compatibility between the second Centella asiatica component and the aqueous gelatin phase, which is beneficial for improving loading stability and release smoothness.

[0083] Comparative Example 3 did not prepare Centella asiatica repair-promoting microparticles; instead, the second Centella asiatica component was directly added to the composite hydrogel. Experimental results showed that the initial release ratio of the second Centella asiatica component was high, and the subsequent cumulative release was also high, indicating that the second Centella asiatica component, without gelatin microparticle encapsulation, was more likely to migrate rapidly out of the hydrogel network. Therefore, gelatin encapsulation to form Centella asiatica repair-promoting microparticles can reduce the risk of rapid initial loss of the second Centella asiatica component and make the release process more gradual.

[0084] In Comparative Example 4, no interfacial fixation components were added. The first Centella asiatica component mainly existed in the antibacterial fixation fabric through physical encapsulation and fiber adsorption. The experimental results showed that the wet retention capacity of the first Centella asiatica component was significantly reduced, indicating that interfacial fixation components such as phytic acid or citric acid can improve the fixation stability of the first Centella asiatica component in the fiber network and reduce its loss in a wet environment.

[0085] In summary, Examples 1-5, compared to the comparative examples, exhibit a more balanced performance in terms of component encapsulation, liquid absorption and breathability, wet retention, sustained release control, and cell compatibility. This demonstrates that the segmented separation, gelatin microparticle encapsulation, composite hydrogel crosslinking, antibacterial spinning fixation, and interface buffering and locking treatment of this application can form a continuous synergy, thereby improving the overall performance of the fabric composition containing Centella asiatica.

[0086] Experiment 2 Procedure: Fabric compositions containing Centella asiatica, prepared in Examples 1-5 and Comparative Examples 1-4 respectively, were used as test samples. Each sample was aseptically cut to the specified specifications and weighed. The samples were then added to sterile eluent and thoroughly shaken to allow migratable microorganisms from the sample surface and interior to enter the eluent, resulting in the sample eluent. Colony testing was conducted according to Appendix B of GB 15979-2024 "Hygienic Requirements for Disposable Sanitary Products," including total bacterial count, total fungal count, coliform bacteria, Staphylococcus aureus, hemolytic streptococci, and Pseudomonas aeruginosa.

[0087] For total bacterial count detection, the sample eluent is serially diluted and inoculated into a bacterial culture medium. The medium is then incubated at the specified temperature. After incubation, the number of colonies is observed and counted, and the total bacterial count is calculated. The result is expressed as CFU / g. For total fungal count detection, the sample eluent is inoculated into a fungal culture medium and incubated at the specified temperature. After incubation, the number of fungal colonies is observed and counted, and the total fungal count is calculated. The result is expressed as CFU / g.

[0088] For the detection of coliform bacteria, Staphylococcus aureus, hemolytic streptococci, and Pseudomonas aeruginosa, the sample eluent is inoculated into the corresponding selective culture medium or enrichment system. After incubation, observe whether the corresponding characteristic colonies appear, and combine with necessary confirmatory tests to determine whether the target bacteria are detected. The test results are interpreted according to GB 15979-2024, wherein the total bacterial count should not exceed 200 CFU / g, the total fungal count should not exceed 100 CFU / g, and coliform bacteria, Staphylococcus aureus, hemolytic streptococci, and Pseudomonas aeruginosa should not be detected.

[0089] The experimental data for Experiment 2 are shown in Table 2.

[0090] Table 2: Experimental data from Experiment 2 showed that the total bacterial and fungal colony counts in Examples 1-5 were at low levels, and coliform bacteria, Staphylococcus aureus, hemolytic streptococci, and Pseudomonas aeruginosa were not detected. This indicates that the fabric composition containing Centella asiatica prepared according to the method of this application can meet the microbial control requirements for disposable hygiene products.

[0091] Compared to the comparative example, Example 1 achieved more stable colony control by using the first and second Centella asiatica components in stages, encapsulating Centella asiatica repair-promoting microparticles, and combining them with an antibacterial Centella asiatica fixation fabric. Example 2, by adding pre-column purification and staged elution, helped reduce the impact of residual impurities on the subsequent material system. Example 3, through a combination of surfactants, mild crosslinking agents, moisturizing and repairing components, and ion-regulating components, maintained good dispersion and wet stability of the hydrogel system. Example 4, by optimizing the antibacterial spinning system and interface fixation components, enhanced the fixation effect of the antibacterial fixation fabric on the first Centella asiatica component. Example 5, through interface buffering and locking treatment, reduced the risk of component migration between the hydrogel layer and the antibacterial fixation fabric, ensuring the stability of the multilayer structure in a wet environment.

[0092] Comparative Example 1 did not involve segmentation of the Centella asiatica component, resulting in unclear functional boundaries of the active components and a relatively lower level of colony control. Comparative Example 2 did not include a surfactant, leading to insufficient dispersibility of the second Centella asiatica component in the gelatin system. Comparative Example 3 did not form Centella asiatica repair-promoting microparticles, making the second Centella asiatica component more likely to remain in a free state. Comparative Example 4 did not include an interface-fixing component, resulting in insufficient wet retention of the first Centella asiatica component in the antibacterial fabric. These results indicate that segmentation, surfactant-assisted dispersion, gelatin microparticle encapsulation, interface fixation, and interface buffering and locking treatment collectively contribute to improving the microbial control stability of the fabric composition.

[0093] It should be understood that this disclosure is not limited to the precise structures described above and shown in the accompanying drawings, and various modifications and changes can be made without departing from its scope. The scope of this disclosure is limited only by the appended claims.

Claims

1. A method for preparing a fabric composition containing Centella asiatica, characterized in that the steps include... include: S1. Add Centella asiatica raw material powder to an ethanol aqueous solution for extraction to obtain Centella asiatica extract. Separate the Centella asiatica extract into segments to obtain a first Centella asiatica component and a second Centella asiatica component. The first Centella asiatica component includes phenolic acids, flavonoids and polyphenolic substances, and the second Centella asiatica component includes asiaticoside, hydroxyasiaticoside, asiaticoside and hydroxyasiaticoside. S2. The second Centella asiatica component is added to a gelatin solution containing surfactant for dispersion and encapsulation to obtain Centella asiatica repair-promoting microparticles. Then, the Centella asiatica repair-promoting microparticles are added to a composite hydrogel liquid for cross-linking to obtain Centella asiatica repair-promoting hydrogel. S3. The first Centella asiatica component and the antibacterial spinning solution are mixed and then spun to obtain the Centella asiatica antibacterial fixing fabric. Then, the Centella asiatica repair-promoting hydrogel, the Centella asiatica antibacterial fixing fabric, and the composite breathable fabric are compounded in sequence to obtain a fabric composition containing Centella asiatica components. The antibacterial spinning solution includes antibacterial components and spinning components.

2. The method for preparing a fabric composition containing Centella asiatica according to claim 1, characterized in that, Step S1 includes: S1.1 Add Centella asiatica raw material powder to an ethanol aqueous solution with a volume fraction of 45% to 55%, the mass-volume ratio of Centella asiatica raw material powder to ethanol aqueous solution is 1g: (8 to 15)mL, continue to add pH buffer to adjust the pH value to 5.0 to 6.0, stir and pre-swell at 35℃ to 45℃ for 20min to 40min to obtain Centella asiatica mixture; S1.

2. The Centella asiatica mixture is extracted by leaching and filtered to obtain Centella asiatica extract. The Centella asiatica extract is then concentrated under low temperature vacuum at a temperature of 35℃~45℃ and a vacuum degree of -0.06MPa~-0.09MPa until the ethanol volume fraction is no higher than 20% to obtain Centella asiatica concentrate. S1.

3. The Centella asiatica concentrate was loaded onto a polyamide resin column for the first stage of separation. The loading flow rate was 0.5 BV / h to 2 BV / h. After loading, purified water was used for elution, followed by desorption and elution with an ethanol aqueous solution with a volume fraction of 35% to 55%. The desorbed eluent was collected to obtain the first Centella asiatica fraction. S1.

4. The effluent from the polyamide resin column is mixed with a 10%–20% (v / v) ethanol aqueous solution and then loaded onto a macroporous adsorption resin column for the second stage separation. The loading flow rate is 0.5 BV / h–1.5 BV / h. After loading, elution is performed using a 20%–35% (v / v) ethanol aqueous solution, followed by desorption elution using a 65%–85% (v / v) ethanol aqueous solution. The desorbed eluent is collected to obtain the second Centella asiatica component, which includes asiaticoside, hydroxyasiaticoside, asiaticoside, and hydroxyasiaticoside. S1.

5. The first and second Centella asiatica components were freeze-dried respectively. During freeze-drying, the components were first pre-frozen at -40℃ for 4 to 8 hours, and then freeze-dried under vacuum for 24 to 36 hours.

3. The method for preparing a fabric composition containing Centella asiatica according to claim 2, characterized in that, In step S1.2, the step of leaching and filtering the Centella asiatica mixture to obtain Centella asiatica extract includes: The Centella asiatica mixture was subjected to ultrasonic-assisted extraction with an ultrasonic power of 200W to 600W, a stirring speed of 100rpm to 300rpm, an extraction temperature of 40℃ to 55℃, and an extraction time of 30min to 90min. After extraction, the mixture was filtered to obtain the first-stage extract and Centella asiatica residue. The Centella asiatica filter residue was added to an ethanol aqueous solution with a volume fraction of 65%–80%, and the mass-volume ratio of Centella asiatica filter residue to ethanol aqueous solution was 1 g: (6–12) mL. The second stage of extraction was carried out under light-proof or nitrogen-protected conditions. The extraction temperature was 50℃–65℃, the stirring speed was 100 rpm–250 rpm, and the extraction time was 1 h–3 h. After the extraction was completed, the solution was filtered to obtain the second stage extract. The first-stage extract and the second-stage extract were mixed and centrifuged and finely filtered. The centrifugation speed was 4000 rpm to 8000 rpm and the centrifugation time was 10 min to 20 min. The fine filtration was carried out using a 0.45 μm to 1.0 μm microporous membrane to obtain the Centella asiatica extract.

4. A method for preparing a fabric composition containing Centella asiatica according to claim 2 or 3, characterized in that, In step S1, the pH buffer solution includes at least one of citrate-sodium citrate buffer, acetic acid-sodium acetate buffer, lactate-sodium lactate buffer, sodium dihydrogen phosphate-disodium hydrogen phosphate buffer, and succinate-sodium succinate buffer, and the macroporous adsorption resin includes one of D101 type macroporous resin, AB-8 type macroporous resin, and HPD type macroporous resin.

5. The method for preparing a fabric composition containing Centella asiatica according to claim 1, characterized in that, Step S2 includes: S2.1 Add gelatin to purified water and stir to dissolve at 45℃~55℃, with a stirring speed of 200rpm~500rpm and a dissolution time of 30min~60min, to obtain a gelatin solution with a mass fraction of 3%~8%. Then add a surfactant to the gelatin solution, with the amount of surfactant added being 0.05%~0.5% of the mass of the gelatin solution, and continue stirring for 10min~30min to obtain a gelatin solution containing surfactant. S2.2 Add the second Centella asiatica component to a gelatin solution containing a surfactant. The mass ratio of the second Centella asiatica component to the gelatin is 1:(5-30). Perform high-speed shear dispersion at 40℃-50℃, with a shearing speed of 6000rpm-12000rpm and a shearing time of 5min-15min. Then perform ultrasonic dispersion with an ultrasonic power of 100W-300W and an ultrasonic time of 3min-10min to obtain the second Centella asiatica gelatin dispersion. S2.

3. Add a mild crosslinking agent to the second Centella asiatica gelatin dispersion for pre-crosslinking treatment. The amount of mild crosslinking agent added is 0.02% to 0.3% of the gelatin mass, the crosslinking temperature is 25℃ to 37℃, and the crosslinking time is 30 min to 3 h to obtain a pre-crosslinked gelatin-loaded liquid. The pre-crosslinked gelatin-loaded liquid is then granulated into microparticles by spray granulation. The nozzle orifice diameter of the granulation equipment is 50 μm to 300 μm, the feed flow rate is 0.2 mL / min to 2 mL / min, the receiving liquid temperature is 4℃ to 15℃, and after collection, it is further cured for 30 min to 120 min to obtain Centella asiatica repair-promoting microparticles. S2.4 Centrifugal washing and particle size sieving of Centrifugal repair-promoting microparticles. Centrifugation speed is 3000rpm~6000rpm, centrifugation time is 5min~15min, washing solution is phosphate buffer with pH value of 6.0~7.0, and after washing 2~3 times, Centrifugal repair-promoting microparticles with particle size of 10μm~200μm are collected. S2.5 The composite hydrogel liquid includes sodium alginate. Centella asiatica repair-promoting microparticles are added to the composite hydrogel liquid, and then calcium ion crosslinking liquid is added for crosslinking. After crosslinking is completed, it is stabilized at 4℃~10℃ for 2h~8h to obtain Centella asiatica repair-promoting hydrogel.

6. The method for preparing a fabric composition containing Centella asiatica according to claim 5, characterized in that, Step S2.5 includes: Oxidized hyaluronic acid was dissolved in purified water to obtain an oxidized hyaluronic acid solution with a mass fraction of 0.5% to 2.0%. Carboxymethyl chitosan and sodium alginate were dissolved in purified water to obtain a carboxymethyl chitosan-sodium alginate composite solution with a mass fraction of 1% to 3% for carboxymethyl chitosan and a mass fraction of 0.5% to 2% for sodium alginate. Moisturizing and repairing components and ion regulating components were then added and stirred evenly to obtain a composite hydrogel precursor solution. Centella asiatica repair-promoting microparticles were added to the composite hydrogel precursor solution for low-speed dispersion. The amount of Centella asiatica repair-promoting microparticles added was 1% to 10% of the mass of the composite hydrogel precursor solution. The dispersion temperature was 20℃ to 30℃, the stirring speed was 80 rpm to 200 rpm, and the dispersion time was 10 min to 30 min to obtain the hydrogel premix. Oxidized hyaluronic acid solution was added to the hydrogel premix for cross-linking. The mixing temperature was 20℃~30℃, the mixing time was 3min~15min, and the pH value was controlled at 6.0~7.2 to obtain a preliminary cross-linked hydrogel. A calcium ion crosslinking solution was added dropwise to the initially crosslinked hydrogel for secondary crosslinking. The amount of calcium ion crosslinking solution added was 1% to 8% of the mass of the initially crosslinked hydrogel. The crosslinking temperature was 20℃ to 30℃, and the crosslinking time was 10 min to 60 min. After the crosslinking was completed, the temperature was lowered to 4℃ to 10℃ and maintained for 2 h to 8 h to obtain the Centella Asiatica repair-promoting hydrogel.

7. The method for preparing a fabric composition containing Centella asiatica according to claim 6, characterized in that, In step S2, the surfactant includes at least one of poloxamer, polysorbate, and lecithin; the mild crosslinking agent includes at least one of genipin and tannic acid; the moisturizing and repairing component includes at least one of sodium hyaluronate, β-glucan, allantoin, and panthenol; the ion regulating component includes at least one of zinc gluconate, zinc lactate, zinc acetate, magnesium chloride, magnesium lactate, and sodium chloride; and the calcium ion crosslinking solution is one of calcium chloride solution, calcium lactate solution, and calcium gluconate solution with a mass fraction of 0.05% to 0.5%.

8. The method for preparing a fabric composition containing Centella asiatica according to claim 1, characterized in that, Step S3 includes: S3.1 Add the spinning component to an organic solvent and stir to dissolve it at 25℃~45℃, with a stirring speed of 200rpm~600rpm and a stirring time of 2h~6h to obtain the spinning base solution. Add the antibacterial component and the interface fixing component to the spinning base solution and stir to disperse it at 20℃~35℃, with a stirring speed of 200rpm~600rpm and a stirring time of 30min~90min. Then perform vacuum degassing treatment to obtain the antibacterial spinning solution. The interface fixing component includes phytic acid or citric acid. S3.2 Add the first Centella asiatica component to the antibacterial spinning solution. The mass ratio of the first Centella asiatica component to the spinning component is 1:(10-50). Disperse the mixture at low speed under the conditions of 20℃-35℃, with a stirring speed of 100rpm-300rpm and a stirring time of 20min-60min to obtain the Centella asiatica antibacterial spinning solution. S3.3 Add the Centella asiatica antibacterial spinning solution to an electrostatic spinning device for spinning treatment. The spinning voltage is 12kV~25kV, the feed speed is 0.2mL / h~1.5mL / h, the distance between the nozzle and the receiving device is 10cm~20cm, the ambient temperature is 20℃~30℃, the ambient relative humidity is 30%~55%, and the spinning time is 0.5h~4h to obtain Centella asiatica antibacterial fixed nascent fabric. S3.4 Cross-linking and curing treatment is carried out on the Centella asiatica antibacterial fixation nascent fabric. When the interface fixing component is citric acid, heat treatment is carried out at 80℃~120℃ for 3min~15min. When the interface fixing component is phytic acid, drying is carried out at 25℃~45℃ for 30min~120min. Then, it is rinsed with purified water 1~3 times and then vacuum dried at 25℃~40℃ for 2h~6h to obtain the Centella asiatica antibacterial fixation fabric. S3.

5. Medical nonwoven fabric and polymer microporous membrane are hot-pressed together at a temperature of 40℃~80℃ and a pressure of 0.05MPa~0.3MPa to obtain a composite breathable fabric. Centella asiatica repair-promoting hydrogel is coated onto a release film with a coating thickness of 0.5mm~3mm. Then, Centella asiatica antibacterial fixing fabric is placed over the side of the Centella asiatica repair-promoting hydrogel away from the release film. The interface is wetted and bonded at 20℃~30℃, and the composite is performed using a roller pressing equipment at a pressure of 0.02MPa~0.15MPa and a speed of 0.1m / min~1m / min to obtain a hydrogel antibacterial fixing fabric composite layer. S3.

6. The composite breathable fabric is covered on the side of the Centella asiatica antibacterial fixing fabric away from the Centella asiatica repair-promoting hydrogel, and the composite is performed by dotting and pressing. The composite temperature is 35℃~65℃, the composite pressure is 0.02MPa~0.2MPa, and the composite time is 5s~60s to obtain a wet composite preform of fabric composition containing Centella asiatica. S3.

7. Stabilize the wet composite preform of the fabric composition containing Centella asiatica at 4℃~10℃ for 2h~8h, and then cut, inspect, sterilize and seal the packaging to obtain the fabric composition containing Centella asiatica.

9. A method for preparing a fabric composition containing Centella asiatica according to claim 8, characterized in that, In step S3, the spinning component includes at least one of silk fibroin, chitosan, and polyvinyl alcohol; the organic solvent includes at least one of aqueous ethanol solution, aqueous acetic acid solution, and hexafluoroisopropanol; the antibacterial component includes at least one of chitosan quaternary ammonium salt, nano zinc oxide, and silver ion antibacterial agent; the polymer microporous membrane includes a polyurethane microporous membrane or a polyethylene microporous membrane; and the sterilization method includes at least one of ethylene oxide sterilization, low-dose irradiation sterilization, or aseptic preparation followed by sealed packaging.

10. A fabric composition containing Centella asiatica extract, characterized in that, It is prepared by the method of preparing a fabric composition containing Centella asiatica as described in any one of claims 1-9.

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