Reagent kit
Patent Information
- Application Number
- CN202610378523.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Priority Date
- 2025-03-28
- Filing Date
- 2026-03-26
- Publication Date
- 2026-09-29
AI Technical Summary
[0006]根据本公开的试剂套件,试剂容器的操作变得容易。根据本公开的试剂套件,例如,由于柔性的试剂容纳袋的形状不易塌陷,因此在将试剂容器设置于样品分析装置时,能够防止由试剂吸管引起的试剂容纳袋的损伤。
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Figure CN122836342A_ABST
Abstract
Description
Technical Field
[0001] This invention relates to reagent kits, and more particularly, to reagent kits having a reagent container comprising a flexible reagent holding bag. Background Technology
[0002] International Publication No. WO 2011 / 105247 discloses a sample analysis apparatus comprising: a reagent container holding part for holding a reagent container; and a reagent pipette that enters from above the reagent container held by the reagent container holding part and draws reagent from the reagent container. Summary of the Invention
[0003] In the sample analysis apparatus disclosed in International Publication No. WO 2011 / 105247, a reagent pipette is inserted into a reagent container held by a reagent container holder, and reagent is drawn from the reagent container each time a sample is measured. However, when reagent is drawn from the reagent container, as the remaining amount of reagent decreases, external air flows into the reagent container, and the reagent remaining in the container comes into contact with the external air. Therefore, it is necessary to suppress the inflow of air into the reagent container after opening. External air may contain bacteria, which can accelerate reagent deterioration.
[0004] The purpose of this invention is to provide a reagent kit that facilitates the operation of reagent containers used in sample analysis devices that can suppress the inflow of air into the reagent container after opening.
[0005] This disclosure provides a reagent kit comprising: a reagent container having a flexible reagent holding bag for holding reagent aspirated by a reagent pipette disposed in a sample analysis device, an opening disposed in the reagent holding bag and allowing the reagent pipette to enter the interior of the reagent holding bag, and a sealing plug for sealing the opening; and a protective member for protecting the reagent container, wherein the protective member has at least one of the following: a container suspension structure configured to suspend the reagent holding bag in a state where the bottom of the reagent holding bag is not supported from below and the opening is sealed by the sealing plug; and a container pressing structure configured to press the reagent holding bag from the outside in a state where the opening is sealed by the sealing plug.
[0006] According to the reagent kit of this disclosure, the handling of the reagent container becomes easier. For example, with the reagent kit of this disclosure, damage to the reagent container caused by the reagent pipette can be prevented when the reagent container is placed in a sample analysis device because the flexible reagent holding bag is less prone to collapse. Attached Figure Description
[0007] Figure 1 (A) to Figure 1(C) is a schematic diagram showing, as an example of an implementation, a reagent container held in a sample analysis apparatus with a pipette inserted into the reagent container.
[0008] Figure 2 This is a perspective view of a reagent container as an example of an implementation method, viewed from the front.
[0009] Figure 3 This is a perspective view of the reagent container as an example of the implementation method, viewed from the rear.
[0010] Figure 4 This is an exploded perspective view of a reagent container as an example of an implementation method.
[0011] Figure 5 yes Figure 3 Sectional view along line AA in the diagram.
[0012] Figure 6 This is a plan view of a reagent container as an example of an implementation method.
[0013] Figure 7 (A) is a diagram showing the large-capacity reagent container viewed from the front. Figure 7 (B) is a diagram showing the small-capacity reagent container viewed from the front.
[0014] Figure 8 (A) is a side view of a large-capacity reagent container. Figure 8 (B) is a side view of a small-capacity reagent container.
[0015] Figure 9 This is a perspective view of a sample analysis apparatus as an example of an implementation method.
[0016] Figure 10 This is a schematic diagram illustrating the structure of a sample analysis apparatus.
[0017] Figure 11 This is a schematic diagram illustrating the structure of a sample analysis apparatus.
[0018] Figure 12 This is a three-dimensional view of the reagent aspiration unit of the sample analysis device.
[0019] Figure 13 This is a 3D view of the reagent aspiration unit, showing the reagent pipette in the rising position.
[0020] Figure 14 This is a three-dimensional view of the reagent aspiration unit, showing the state in which the reagent container is held in the reagent container holding section.
[0021] Figure 15 It means Figure 14 A partial view of the BB line profile.
[0022] Figure 16 (A) is a diagram showing the state before the protruding member and the frame member are engaged. Figure 16 (B) is a diagram representing the state after the card is engaged.
[0023] Figure 17 It is a cross-sectional view of the reagent aspiration section (a cross-sectional view cut in the vertical direction along the depth direction of the reagent aspiration section), showing the state in which the reagent container is held in the reagent container holding section and the reagent pipette is in the rising position.
[0024] Figure 18 This is a cross-sectional view of the reagent aspiration section, showing the state in which the reagent container is held in the reagent container holding section and the reagent pipette is in the descending position.
[0025] Figure 19 (A) is a cross-sectional view showing the state of the reagent container before the opening is sealed by the reagent pipette's sealing body. Figure 19 (B) is a cross-sectional view showing the sealed state (B).
[0026] Figure 20 It is a cross-sectional view obtained by horizontally cutting the reagent container holding part of the reagent aspiration unit along the depth direction.
[0027] Figure 21 This is a cross-sectional view of the reagent container holding section.
[0028] Figure 22 This is a cross-sectional view of the reagent container holding section, showing the state in which the reagent container is held.
[0029] Figure 23 From Figure 21 A diagram of the inner surface portion of the sidewall and rearwall removed from the cavity.
[0030] Figure 24 It is a three-dimensional view of the inner surface of the side wall of the reagent container holding part with the pressing part formed.
[0031] Figure 25 This is a diagram showing a first modified example of the reagent container holding part.
[0032] Figure 26 This is a diagram showing a second modified example of the reagent container holding part.
[0033] Figure 27 (A) to Figure 27 (C) is a diagram showing a third modified example of the reagent container holding part.
[0034] Figure 28 (A) to Figure 28 (C) is a diagram showing a fourth modified example of the reagent container holding part.
[0035] Figure 29 This is a diagram showing the fifth modified example of the reagent container holding section.
[0036] Figure 30 This is a perspective view of the reagent kit as an example of an implementation method, viewed from the front.
[0037] Figure 31 This is a perspective view of the reagent kit as an example of an implementation method, viewed from the rear.
[0038] Figure 32 This is a three-dimensional view of the protective components that make up the reagent kit, viewed from the front.
[0039] Figure 33 This is a three-dimensional view of the protective components that make up the reagent kit, viewed from the rear.
[0040] Figure 34 This is a side view of the protective components that make up the reagent kit.
[0041] Figure 35 (A) is a diagram showing the reagent kit viewed from the front in a static state. Figure 35 (B) is a diagram of the reagent kit viewed from the front under the condition of an external force acting in the vertical direction.
[0042] Figure 36 This is a diagram showing a small-capacity reagent kit as an example of an implementation method, viewed from the front.
[0043] Figure 37 This is a diagram showing a first variation of the reagent kit.
[0044] Figure 38 This is a diagram showing a second variation of the reagent kit.
[0045] Figure 39 This is a diagram showing a third variation of the reagent kit.
[0046] Figure 40 This is a diagram showing the fourth variation of the reagent kit.
[0047] Figure 41 This is a diagram representing the fifth variation of the reagent kit. Detailed Implementation
[0048] Hereinafter, embodiments of the reagent kit of the present invention will be described in detail with reference to the accompanying drawings. The embodiments described below are merely examples, and the present invention is not limited to the embodiments described below. Furthermore, configurations formed by selectively combining the constituent elements of various embodiments and variations described below are also included in the present invention. Figure 1 (A) to Figure 1(C) is a diagram schematically showing the state in which the reagent container 100 is held in a sample analysis apparatus 300 as an example of an embodiment. Figure 1 (A) is a three-dimensional view of reagent container 100. Figure 1 (B) is a diagram showing the state in which the reagent container 100 is held in the reagent container holding section 251 of the sample analysis device 300. Figure 1 (C) is a diagram showing the state in which the reagent pipette 252 is inserted into the reagent container 100 held in the reagent container holding part 251 and the reagent 12 is drawn. Figure 1 (A) to Figure 1 As shown in (C), the sample analysis apparatus 300 is a device using a reagent container 100 comprising a flexible reagent container bag 10 containing reagent 12, and includes a reagent aspiration section 250 comprising a reagent pipette 252 and a reagent container holding section 251 for holding the reagent container 100. The reagent aspiration section 250 forms part of the sample preparation section (measurement sample preparation section) described later. The sample preparation section has a reagent pipette 252 for aspirating reagent 12 from the reagent container 100, and prepares a measurement sample using the sample and reagent 12. The sample is, for example, blood. The reagent container holding section 251 is located at a position accessible from the front of the sample analysis apparatus 300. As will be described in detail below, the sample analysis apparatus 300 is a blood cell counting device that detects signals corresponding to blood cells in the measurement sample, analyzes the detection signals, and counts the blood cells. Figure 1 As shown in (A), the reagent container 100 includes a flexible reagent holding bag 10 with an opening 21a and a sealing plug 21b for sealing the opening 21a. The reagent container 100 includes a cylindrical plug member 21 installed on the reagent holding bag 10, forming an opening 21a that allows the reagent pipette 252 to enter the interior of the reagent holding bag 10. In the reagent holding bag 10, the interior and exterior are connected only through the opening 21a, and the reagent 12 and air cannot pass through any part other than the opening 21a. The plug member 21 is installed at the end of the reagent holding bag 10, and the reagent container 100 is operated with the opening 21a of the plug member 21 vertically upward. Hereinafter, the portion where the plug member 21 is provided will be referred to as the upper part of the reagent holding bag 10. The reagent container 100 also includes a frame member 23 provided on the upper part of the reagent holding bag 10. The frame member 23 is a member at least partly formed as a plate, having a fixing part 26 for inserting the plug member 21. The frame member 23 is mounted to the reagent container bag 10 via the bolt member 21. Furthermore, the frame member 23 is made of a material with higher rigidity than the reagent container bag 10. The bolt member 21 is configured to be biased towards one end of the reagent container bag 10 in a direction orthogonal to both the vertical and thickness directions. Figure 1As shown in (B), the reagent container 100 is inserted into the reagent container holding part 251 of the sample analysis device 300 with the opening 21a of the plug member 21 facing upwards. The reagent container 100 is inserted into the reagent container holding part 251 with the plug member 21 side of the reagent container bag 10 as the front end. The reagent pipette 252 is positioned directly above the reagent container holding part 251 and is movable in the vertical direction. The reagent container 100 is inserted to a set position Ps where the center of the opening 21a coincides with the central axis of the reagent pipette 252. The reagent container holding part 251 is a part for aspirating the reagent 12 and is configured as part of the reagent aspiration part 250. The reagent container holding part 251 has guide grooves 270 for smooth insertion of the reagent container 100. Each guide groove 270 is a guide frame member 23 that guides the reagent container 100 to slide into the interior of the reagent container holding part 251. A pair of guide grooves 270 are provided on the upper part of the reagent container holding portion 251 to clamp the reagent container 100 from both sides in the thickness direction. The position of the reagent container 100 is restricted within the reagent container holding portion 251 by the frame member 23 fitting into the guide grooves 270. Furthermore, the reagent container 100 is positioned at a set position Ps by the front end of the frame member 23 abutting against the groove wall deep within the guide groove 270. That is, the frame member 23 has a shape corresponding to the internal shape of the reagent container holding portion 251. Figure 1As shown in (C), after the reagent container 100 is housed in the reagent container holding section 251, the reagent pipette 252 is inserted into the reagent receiving bag 10 through the opening 21a by operating the operating section 253, passing through the sealing plug 21b. The sample analysis apparatus 300 includes an operating section 253 for moving the reagent pipette 252 in the vertical direction. In this embodiment, the operating section 253 also serves as a front cover for closing the inlet of the reagent container holding section 251. Therefore, after the reagent container 100 is held in the reagent container holding section 251, the inlet of the reagent container holding section 251 is closed by pulling down the operating section 253, which serves as the front cover, and the reagent pipette 252 descends and is inserted into the reagent receiving bag 10. The reagent pipette 252 has a sealing body 252a that seals the opening 21a when it is in the state of passing through the sealing plug 21b and entering the reagent receiving bag 10. Because the reagent pipette 252 has the rigidity to penetrate the sealing plug 21b of the reagent container 100, as the reagent pipette 252 descends, it can penetrate the sealing plug 21b and enter the interior of the reagent holding bag 10. At this time, although the sealing plug 21b is opened, the opening 21a is blocked by the sealing body 252a pressing against the periphery of the opening 21a, thus preventing the reagent 12 from contacting the air (external air) outside the reagent holding bag 10. The sealing body 252a is located at the axial middle of the reagent pipette 252 and can block the opening 21a of the plug member 21. The sealing body 252a is, for example, made of elastically deformable rubber and moves in the vertical direction together with the reagent pipette 252. In the sample analysis apparatus 300, once the reagent pipette 252 is inserted into the opening 21a of the unused reagent container 100 and the sealing body 252a is pressed against the periphery of the opening 21a, the reagent pipette 252 can remain inserted until the reagent 12 in the reagent holding bag 10 is completely consumed. Although the sealing plug 21b is opened, the interior of the reagent holding bag 10 is sealed by the sealing body 252a, thus preventing the reagent 12 inside the reagent holding bag 10 from contacting the outside air. As a result, the quality deterioration of the reagent 12 can be suppressed, and the reagent container 100 can be used for a long time with the reagent pipette 252 still inserted. In addition, when using a non-deformable rigid reagent container, if reagent aspiration is performed in a sealed state, as the reagent decreases, the internal pressure of the reagent container decreases, and it becomes impossible to aspirate the reagent due to the balance with the aspiration pressure. Therefore, the interior of the container must be opened to the atmosphere. Thus, as the remaining amount of reagent decreases, outside air flows into the reagent container. In contrast, since the reagent container 100 has a flexible reagent holding bag 10, the reagent holding bag 10 shrinks and deforms itself when the reagent 12 is drawn in, thereby preventing a decrease in internal pressure. As a result, the reagent 12 can be drawn in even when sealed. Therefore, even if the remaining amount of reagent decreases, external air will not flow into the reagent container 100. Furthermore, the reagent holding bag 10 is formed of a material and shape that can deform when the reagent is drawn in during the sealed state.As described above, according to the reagent container 100, since the opening 21a is sealed by the sealing body 252a, the deterioration of the reagent 12 caused by contact between the reagent 12 inside the reagent container 10 and the outside air can be suppressed. If the reagent 12 can be used continuously for a longer period of time while the reagent container 100 is installed in the sample analysis device 300, the capacity of the reagent container 10 can be increased, and more reagent aspirations can be performed from one reagent container 100. As a result, for example, the replacement frequency of the reagent container 100 can be reduced, and the ease of use can be improved. On the other hand, if a flexible reagent container 10 is used, the position of the opening 21a when the reagent pipette 252 is inserted into the reagent container 10, or the position of the opening 21a while the reagent pipette 252 is inserted, is easily changed by external force. Therefore, the positioning of the opening 21a and preventing the positional displacement of the opening 21a become important for the sealing of the reagent container 10. In this embodiment, the relative position of the opening 21a and the sealing body 252a is precisely determined by the function of the frame member 23 of the reagent container 100 and the guide groove 270 of the sample analysis device 300, enabling a reliable seal of the opening 21a. Furthermore, since the movement of the reagent container 100 is restricted, the sealing state of the reagent container 10, achieved by the sealing body 252a, is maintained while the reagent pipette 252 is inserted into the reagent holding bag 10. Details will be described later. For example, under external forces such as vibration or impact during transportation, the flexible reagent holding bag may deform inwards. If the reagent holding bag is held in the sample analysis device in such a deformed state, the descending reagent pipette may pierce the deformed portion of the bag, causing the reagent holding bag to break and reagent leakage. To address this problem, the sample analysis device 300 provides a pressing part in the reagent container holding part 251 for pressing the reagent holding bag 10, whose opening 21a is sealed, from the outside to correct the shape of the reagent holding bag 10. Furthermore, in order to suppress deformation of the reagent container 10 during transportation, the reagent container 100 is protected by the protective member 460 and by the reagent kit 450 (see reference). Figure 30 (etc.) status is provided. See below for reference. Figures 2-6 The composition of reagent container 100 is described in detail. Figure 2 This is a three-dimensional view of reagent container 100 as seen from the front. Figure 3 This is a three-dimensional view of reagent container 100 viewed from the rear. Figure 4 This is an exploded perspective view of the reagent container 100. For ease of explanation, the vertical direction will be designated as the Z-direction, with the reagent container 100 inserted into the reagent container holding part 251 (see reference). Figure 1 (A) to Figure 1The direction of (C) is designated as direction A, and the direction orthogonal to both direction A and direction Z is designated as direction B. Additionally, direction A is sometimes referred to as the front-to-back direction of reagent container 100, and direction B is sometimes referred to as the thickness direction of reagent container 100. For example... Figures 2-4 As shown, the reagent container 100 includes a reagent holding bag 10, a plug member 21 attached to the reagent holding bag 10, and a frame member 23 attached to the reagent holding bag 10 via the plug member 21. In this embodiment, as described above, the plug member 21 forms a structure that allows the reagent pipette 252 (see reference 252) to pass through. Figure 1 (A) to Figure 1 The reagent container 10 has an opening 21a (C) that allows the reagent to enter the interior of the reagent container 10, and a sealing plug 21b is provided on the plug member 21 to block the opening 21a. The frame member 23 has a rectangular shape in plan view and is arranged to cover the reagent container 10 from above. The length of the frame member 23 in the A direction is slightly longer than the length of the reagent container 10 in the A direction. On the other hand, since the reagent container 10 expands in the B direction, the length of the reagent container 10 in the B direction is longer than the length of the frame member 23 in the B direction. In addition, a handle 25 is formed on the frame member 23 for the user to hold when operating the reagent container 100.
[0049] [Reagent container bag]
[0050] The reagent container 10 is a flexible packaging material container that is easily deformed by external force. It is a flat container made of a flexible sheet. The reagent container 10 is also known as a pouch. The reagent container 10 is a corner pouch. The corner pouch has a first face, a second face opposite to the first face, and a corner portion folded between the first and second faces and functioning as a gusset. Although it can be formed by folding a single sheet, it is preferably made of multiple sheets. The reagent container 10 is, for example, made of three sheets. The reagent container 10 has two wall sheets 11. The wall sheets 11 form a pair of wall faces arranged opposite each other. The reagent container 10 also has corner sheets 13 inserted between the two wall sheets 11. The wall sheets 11 are, for example, formed into a generally quadrilateral shape. The wall sheets 11 can be generally square or generally rectangular, slightly longer in the vertical or front-back direction. The two wall sheets 11 have the same shape and size. The shape of the reagent container 10 depends primarily on the shape of the wall sheets 11. The corner piece 13 is smaller than the wall sheets 11 and is folded between the two wall sheets 11. In the case of a corner bag, generally, increasing the size of the corner piece 13 increases the capacity of the reagent container 10. The reagent container 10 has a joint 14 formed by heat-melting the wall sheets 11 together and the corner piece 13. The joint 14 can be formed using an adhesive, but it is preferable to form it by heat-melting the individual sheets. By bonding these sheets together, an internal space with a sealed periphery is formed. The corner piece 13 is inserted between the two wall sheets 11 in a folded state, and its periphery can be unfolded and joined to the inner surface of each wall sheet 11. Furthermore, details will be described later. The bolt member 21 is fused to each of the two wall sheets 11 while the base portion 22 is inserted between them. (The rest of the text will be omitted.) Figures 2-4 In addition, refer to appropriately Figure 5 . Figure 5 yes Figure 3 The AA-line sectional view in the diagram. (Example) Figure 5As shown, the reagent 12 contained in the reagent container bag 10 is a liquid. The reagent container bag 10 is filled with a quantity of reagent 12 that is, for example, 60% to 90% of the internal volume of the bag. Reagent 12 is an aqueous solution containing components corresponding to the analytical items analyzed in the sample. The reagent container 100 contains a staining solution, as reagent 12, used to stain specified cells. The staining solution contains, for example, various fluorescent dyes used to stain white blood cells, red blood cells, or platelets in blood, or organelles within blood cells. The storage period of reagent 12 is, for example, 75 days to 1 year after the reagent pipette 252 is inserted into the opening 21a. The storage period refers to the length of time during which the accuracy of the measurement using reagent 12 can be guaranteed by the sample analysis device 300. In this embodiment, with the reagent pipette 252 inserted into the opening 21a and the inside of the reagent container bag 10 sealed, the measurement accuracy is maintained for a period of 75 days to 1 year. Because the sealing of the reagent container bag 10 can suppress the deterioration of the reagent 12, the reagent quality can be maintained stably for a longer period. As a result, the replacement frequency of the reagent container 100 can be reduced, alleviating the burden on users associated with replacement operations. The following, except... Figures 2-4 In addition, refer to appropriately Figure 6 . Figure 6 This is a plan view of reagent container 100. (Example) Figure 3 and Figure 6As shown, the reagent container 10 is configured such that by filling it with reagent 12, the corner piece 13 unfolds, and the two wall pieces 11 expand away from each other. In this embodiment, the side of the reagent container 10 with the corner piece 13 is designated as the rear side, and the side opposite to the corner piece 13 is designated as the front side. At the front end of the reagent container 10, the two wall pieces 11 are joined together without passing through the corner piece 13. Therefore, the front end and its vicinity of the reagent container 10 have a small thickness and are tapered. The thickness of the reagent container 10 increases with distance from the front end; for example, it has the same thickness from the center in the front-rear direction to the rear end, or the thickness gradually increases towards the rear end. The thickness (length in the B direction) of the reagent container 10 is less than the length in the B direction of the frame member 23 at the front end of the reagent container 10, but greater than the length in the B direction of the frame member 23 at the center in the front-rear direction. In the plan view of the reagent container 100, except for the front end and its vicinity, the reagent container 10 protrudes outward more than both ends of the frame member 23 in the width direction. The wall sheet 11 and the corner sheet 13 are made of a laminated film with gas barrier and light-shielding properties. Gas barrier refers to the property that makes it difficult for gases to pass through. In this specification, gas barrier means that air, especially oxygen, cannot pass through. Light-shielding means that light cannot pass through. By using a laminated film with gas barrier and light-shielding properties, the reagent 12 contained in the reagent container 100 can be prevented from deteriorating due to external air and external light such as sunlight. As a result, the deterioration of the reagent 12 can be suppressed for a long time. The laminated film, for example, includes at least one substrate layer and at least one gas barrier layer. In addition, the laminated film preferably includes a light-shielding layer made of a light-shielding material. The laminated film may also include a protective layer that protects the outer surface of the gas barrier layer. When a material with both gas barrier and light-shielding properties is used for the gas barrier layer, the gas barrier layer and the light-shielding layer may be the same layer. The number of layers in the laminated film is two or more, but it may also be three to nine or ten or more, without particular limitation. The aforementioned laminated film, for example, has a stacked structure of nylon (15 μm) / aluminum foil (9 μm) / polyethylene (9 μm) sequentially from the outside of the reagent holding bag 10. In this case, the nylon functions as a protective layer, the aluminum foil functions as a gas barrier layer and a light-shielding layer, and the polyethylene functions as a substrate layer. The reagent holding bag 10 is formed into a bag shape by thermally fusing the polyethylene layers of each sheet together. The laminated film is a metal foil laminated film formed by stacking gas barrier layers made of metal foil between resin layers. In addition to the above, the laminated film can, for example, be a resin-based multilayer barrier film, a coating-based film, a vapor-deposited film, an organic-inorganic composite film, etc. A resin-based multilayer barrier film is a film with a structure having gas barrier layers of stacked resin materials. Resin materials with excellent gas barrier properties include, for example, PVDC (polyvinylidene chloride), PVA (polyvinyl alcohol), EVOH (ethylene-vinyl alcohol copolymer), etc. A coating-based film is a film with a structure in which a gas barrier material is coated (film-formed) on a substrate layer.Examples of barrier materials used in film formation include PVDC, PVA, and EVOH. A vapor-deposited film is a film with a structure in which a barrier material is deposited onto a substrate layer. Examples of the vapor-deposited barrier materials include metals such as aluminum or steel, or inorganic oxides such as alumina or silicon dioxide. Organic-inorganic composite films include laminates with structures that separately layer an organic material (resin material) barrier layer and an inorganic material barrier layer, or films with a barrier layer formed by dispersing inorganic materials in an organic binder.
[0051] [Bolt component]
[0052] like Figures 2-4 As shown, the plug member 21 is installed in the reagent container bag 10, forming an opening 21a leading to the interior of the reagent container bag 10. The plug member 21 has a cylindrical portion 21d for the reagent pipette 252 to pass through, and a base portion 22 held between two wall sheets 11. The plug member 21 is installed in the reagent container bag 10 by joining the base portion 22 to each wall sheet 11 using the joint portion 14 of the reagent container bag 10. In other words, the joint portion 14 is formed by thermally fusing each sheet to the base portion 22 while the base portion 22 is held between the two wall sheets 11. Figure 4 and Figure 5 As shown, the plug member 21 also has a straw guide portion 21c, which is formed at a position aligned vertically with the tube portion 21d. The straw guide portion 21c extends across the base portion 22 in the opposite direction to the tube portion 21d, facilitating the smooth insertion of the reagent straw 252 into the reagent container bag 10. Furthermore, a protrusion 22a is formed on the base portion 22, protruding in the same direction as the tube portion 21d. The protrusion 22a, together with the tube portion 21d, serves to fix the frame member 23. The plug member 21 is made of rigid resin. The resin constituting the plug member 21 is, for example, a thermoplastic resin capable of injection molding, preferably one capable of heat-welding the wall sheet 11. Examples of resins constituting the plug member 21 include polyolefins such as polyethylene (PE) and polypropylene (PP), and polytetrafluoroethylene (PET). The straw guide portion 21c, the tube portion 21d, and the base portion 22 are preferably integrally molded from thermoplastic resin. The cylindrical portion 21d has openings at both axial ends, forming a generally cylindrical shape. One axial end of the cylindrical portion 21d is disposed inside the reagent holding bag 10, and the other axial end is disposed outside the reagent holding bag 10. The opening of the cylindrical portion 21d becomes an opening 21a that allows the reagent pipette 252 to enter. A sealing plug 21b is provided at one axial end of the cylindrical portion 21d to seal the opening 21a and prevent the reagent 12 from leaking out of the opening 21a. The sealing plug 21b is, for example, a sealing film that can be punctured by the reagent pipette 252, covering the entire opening 21a and adhering to the periphery of the opening 21a. Although the sealing plug 21b is opened by puncturing the reagent pipette 252, it is still opened by the sealing body 252a of the reagent pipette 252 (see reference). Figure 1 (A) to Figure 1(C) Pressing the periphery of the opening 21a seals the opening 21a, thus sealing the interior of the reagent container 10. Alternatively, the sealing plug 21b can be a plug inserted into the cylindrical portion 21d or an external plug embedded in the cylindrical portion 21d. However, the sealing plug 21b is preferably one through which the reagent pipette 252 can pass without requiring user disassembly. The base portion 22 is generally boat-shaped, narrowing at both ends along its long side, and has a planar hexagonal shape. In this embodiment, the outer peripheral surface of the base portion 22 is heat-fused to the wall sheet 11. Therefore, there is no gap between the wall sheet 11 and the plug member 21, and the plug member 21 is installed at the end of the reagent container 10. Furthermore, the plug member 21 has the following structure: the cylindrical portion 21d and the pipette guide portion 21c protrude from one end of the base portion 22 along its long side, and the protrusion 22a protrudes from the other end of the long side in the same direction as the cylindrical portion 21d. The cylindrical portion 21d extends from the base portion 22 toward the outside of the reagent holding bag 10, and the pipette guide portion 21c extends from the base portion 22 toward the inside of the reagent holding bag 10. The root of the cylindrical portion 21d is narrower than the upper portion. In addition, the root of the protrusion 22a is thinner than the upper portion, and has a roughly T-shaped appearance when viewed from the long side of the base portion 22. Details will be described later. The cylindrical portion 21d and the protrusion 22a fit into the through hole of the frame member 23, thereby fixing the frame member 23 to the reagent holding bag 10. The plug member 21 is disposed on the side opposite to the corner sheet 13 in the A direction of the reagent holding bag 10 (one end side in the A direction, the front end side). In addition, the cylindrical portion 21d of the plug member 21 is located closer to the front end side of the reagent holding bag 10 than the protrusion 22a. As described above, the reagent container bag 10 expands significantly in the B direction (thickness direction) due to the unfolding of the corner piece 13 at the other end (rear end) in direction A, but since there is no corner piece at the front end of the reagent container bag 10, the expansion of the front end is smaller. As described above, the front end of the cylindrical portion 21d with the plug member 21 in the reagent container bag 10 has a smaller thickness. Therefore, if the reagent pipette 252 is inserted at an angle relative to the central axis of the cylindrical portion 21d, it is expected that the front end of the reagent pipette 252 will contact the inner surface of the reagent container bag 10. To solve this problem, a pipette guide portion 21c extending into the interior of the reagent container bag 10 is provided on the plug member 21. The pipette guide portion 21c is formed as a wall to separate the reagent pipette 252 inserted from the opening 21a from the inner surface of the wall sheet 11. Thus, even when the reagent pipette 252 is inserted at an angle relative to the central axis of the cylindrical portion 21d, it is possible to prevent the front end of the reagent pipette 252 from contacting the wall sheet 11. On the other hand, the thickness of the reagent holding bag 10 increases in the central part of the reagent holding bag 10 in the front-rear direction, and the possibility of the front end of the reagent pipette 252 contacting the inner surface of the wall sheet 11 is low. Therefore, the pipette guide 21c is not formed in the central part of the front-rear direction than the opening 21a.The pipette guide portion 21c, except for a portion surrounding the reagent pipette 252 inserted from the opening 21a, is formed in a C-shaped cross-section to surround its surroundings. Furthermore, details will be described later; in this embodiment, measures are taken to suppress the reagent container 10 from reaching the set position Ps (see reference) of the reagent container holding portion 251. Figure 1 (A) to Figure 1 The deformation at (C) can more effectively suppress the contact between the tip of the reagent pipette 252 and the wall sheet 11.
[0053] [Frame Components]
[0054] like Figures 2-4 As shown, the frame member 23 is a plate-shaped member installed on the upper part of the reagent container bag 10, and is inserted into the guide groove 270 of the reagent container holding part 251 (see reference). Figure 1 (A) to Figure 1 The reagent container 100 (C) can be smoothly inserted into the reagent container holding part 251. Furthermore, the frame member 23 is used for positioning the reagent container 100 within the reagent container holding part 251. The frame member 23 is a position limiting member that restricts the position of the reagent container 100 by abutting against the groove wall of the guide groove 270. This suppresses positional misalignment between the reagent pipette 252 and the opening 21a, and effectively maintains the sealed state of the reagent container bag 10 after the sealing plug 21b is opened. Figure 6 As shown, the frame member 23 is formed in a rectangular shape in plan view, and is arranged to cover the upper part of the reagent container bag 10, with the long side of the rectangle extending along the front-back direction of the reagent container bag 10 and the short side extending along the thickness direction of the reagent container bag 10. A fixing part 26 for inserting the cylindrical portion 21d of the plug member 21 is formed at one end of the frame member 23 along the long side, and a holding part 25 is formed at the other end of the frame member 23 along the long side. Most of the frame member 23 is formed as a flat plate, but the other end along the thickness direction of the flat plate forms a holding part 25 that can be gripped with fingers. The frame member 23 is made of rigid resin. The resin constituting the frame member 23 is a thermoplastic resin that can be injection molded. Examples of resins constituting the frame member 23 include polyolefins such as polyethylene (PE) and polypropylene (PP), and polytetrafluoroethylene (PET). Preferably, the frame member 23, including the holding part 25, is integrally molded from thermoplastic resin. Figure 4As shown, the frame member 23 has a fixing part 26 into which the cylindrical portion 21d of the plug member 21 is inserted, and a support part 27 into which the protrusion 22a of the plug member 21 is inserted. The fixing part 26 and the support part 27 are through holes formed in the flat plate portion of the frame member 23. Details will be described later. By engaging the fixing part 26 with the cylindrical portion 21d and the support part 27 with the protrusion 22a, the frame member 23 is stably mounted on the reagent container bag 10. Furthermore, an information recording medium 28 recording information about the reagent 12 is provided on the frame member 23. The information recording medium 28 is positioned at the center of the long side of the frame member 23 to cover the support part 27. The frame member 23 also has a cutout 23c. The cutout 23c is for the protruding member 273 of the sample analysis device 300 (see later description). Figure 16 (A) to Figure 16 The recessed portion (B) is formed at the center of the long side of the frame member 23, along the end of the long side. The cutout 23c has a planar triangular shape and is formed on both sides of the frame member 23 in the width direction. In addition, the frame member 23 has a through hole 23d formed on the side further from the front end 23a than the fixing portion 26. The through hole 23d is for the fixing pin 280 of the sample analysis device 300 (see below). Figure 17The insertion portion has two aligning sections in the width direction of the frame member 23. Furthermore, the number of cutouts 23c and through holes 23d is not limited to two. The frame member 23 is mounted to the reagent container 100 in the front-rear direction with the gripping portion 25 located on the side opposite to the plug member 21, in other words, on the side of the insertion corner sheet 13. When inserting the reagent container 100 into the reagent container holding portion 251, the user holds the gripping portion 25 and inserts it horizontally with the plug member 21 side as the front end. The gripping portion 25 side of the reagent container 10 expands in the thickness direction due to the unfolding of the insertion corner sheet 13, but the thickness of the plug member 21 side is smaller and it is tapered. Therefore, if the reagent container holding portion 251 is inserted first from the plug member 21 side, the insertion of the reagent container 100 is smooth. The gripping portion 25 is formed from the rear end 23b of the frame member 23 with a length that is easy to grip with fingers. Therefore, when inserting the reagent container 100 into the reagent container holding part 251, it is not necessary to insert fingers deep into the reagent container holding part 251, making the operation of the reagent container 100 easy and preventing fingers from contacting the reagent pipette 252. A pair of gripping sides 25a extending in the A and Z directions are formed on the gripping part 25. As a result, the gripping part 25 can be gripped from the left and right. The gripping form for gripping with fingers makes it easy for the user to apply force in a small area and can stably hold the reagent container 100. The gripping part 25 is formed at the center of the frame member 23 in the width direction with a predetermined front-to-back length from the rear end 23b. The width of the gripping part 25 (the distance between the pair of gripping sides 25a) is less than the width of the flat portion of the frame member 23. A wall portion 25b is provided on the rear end 23b side of the pair of gripping sides 25a. The inner space surrounded by a pair of gripping sides 25a and a wall portion 25b is hollow, and the corner of the reagent container 10 is contained within this inner space. Therefore, the corner of the reagent container 10 is not exposed near the gripping portion 25, and the user will not come into contact with the corner of the reagent container 10 when holding the gripping portion 25. The frame member 23 functions as a position limiting member in the reagent container holding portion 251, and also functions as a support member supporting the weight of the reagent container 10 when handling the reagent container 100. The frame member 23 has a fixing portion 26 that engages with the cylindrical portion 21d of the plug member 21, and a support portion 27 that engages with the protrusion 22a of the plug member 21 at a position away from the cylindrical portion 21d. When handling the reagent container 100, the reagent container 10 can be supported in a suspended manner at multiple positions of the fixing portion 26 and the support portion 27. Because the weight of the reagent container 10 is distributed across multiple locations on the frame member 23, it can be stably supported even when the capacity of the reagent container 10 is increased. Furthermore, since the user does not need to hold the easily deformable reagent container 10, the operation of the reagent container 100 becomes easier. A fixing part 26 is provided between the center portion along the long side of the frame member 23 and the front end 23a.The fixing part 26 is a through hole penetrating the frame member 23 in the thickness direction (vertical direction), including a first hole 26a allowing the upper part of the cylindrical part 21d to pass through, and a second hole 26b that engages with the root part, which is narrower than the upper part of the cylindrical part 21d. The second hole 26b is smaller than the first hole 26a and communicates with the first hole 26a. The second hole 26b is sized to hold the root part of the cylindrical part 21d. The support part 27 is provided at the center of the frame member 23 in the long side direction. The support part 27 is a through hole penetrating the frame member 23 in the thickness direction, including a first hole 27a allowing the upper part of the protrusion 22a to pass through, and a second hole 27b that engages with the root part, which is thinner than the upper part of the protrusion 22a. The second hole 27b is smaller than the first hole 27a and communicates with the first hole 27a. The second hole 27b is sized to hold the root part of the protrusion 22a. Here, the method of installing the frame member 23 onto the bolt member 21 is described. With the first hole 26a of the fixing part 26 and the first hole 27a of the support part 27 aligned horizontally with respect to the cylindrical portion 21d and the protrusion 22a of the bolt member 21, the frame member 23 is brought close to the bolt member 21 from above. As a result, the cylindrical portion 21d is inserted into the first hole 26a, and the protrusion 22a is inserted into the first hole 27a. Then, the frame member 23 is moved relative to the bolt member 21 in the direction A. As a result, the root of the cylindrical portion 21d enters the second hole 26b from the first hole 26a and is held by the edge portion of the second hole 26b. Similarly, the root of the protrusion 22a enters the second hole 27b from the first hole 27a and is held by the edge portion of the second hole 27b. The information recording medium 28 is a medium that records information about the reagent 12, such as an RFID (radio frequency identifier) tag. Therefore, when the reagent container 100 is placed in the reagent container holding part 251, the sample analysis device 300 can read the information of the reagent 12 from the information recording medium 28. The information recording medium 28 has a flat plate shape and is provided on the upper surface 23f of the frame member 23. In addition, the information recording medium 28 is provided in a manner that covers the support part 27 of the frame member 23. Figure 7 (A) to Figure 7 (B) and Figure 8 (A) to Figure 8 (B) is a diagram representing two reagent containers, 100 and 200. Figure 7 (A) is a diagram showing the large-capacity reagent container 100 viewed from the front. Figure 7 (B) is a diagram showing the small-capacity reagent container 200 viewed from the front. Figure 8 (A) is a side view of the large-capacity reagent container 100. Figure 8 (B) is a side view of the small-capacity reagent container 200. (See diagram below.) Figure 7 (A) to Figure 7 (B) and Figure 8(A) to Figure 8 As shown in (B), reagent container 100 is larger than reagent container 200, and is a large-capacity container that can hold more reagent 12 than reagent container 200. The reagent holding bag 10 of reagent container 100 holds, for example, 100 mL or more and 500 mL or less, or 200 mL or more and 500 mL or less of reagent 12. Due to the large-capacity reagent holding bag 10, the replacement frequency of reagent container 100 in sample analysis device 300 is reduced. On the other hand, although there is concern that prolonged contact with air during reagent pipette insertion 252 could lead to reagent 12 deterioration, in this embodiment, since the reagent holding bag 10 is sealed by the sealing body 252a, the quality of reagent 12 can be maintained even with prolonged use. Furthermore, by setting the capacity of reagent 12 to 100 mL or more or 200 mL or more, the weight of the reagent holding bag 10 holding reagent 12 is increased, which allows for effective shape correction when the reagent holding bag 10 is pressed from the outside by the pressing part 350 (described later). By setting the capacity of reagent 12 to 500 mL or less, the large-scale nature of sample analysis devices can be suppressed. The reagent container 200's reagent holding bag 110 holds, for example, a quantity of reagent 12 of 20 mL or more but less than 100 mL. For small-capacity reagent containers 200, the degradation of reagent 12 can also be suppressed by sealing the reagent holding bag 110. Furthermore, the reagent holding bag 10 has a corner piece 13 that functions as a corner support, but the reagent holding bag 110 does not have a corner piece. Therefore, when filled with reagent 12, the reagent holding bag 110 is thinner and flatter than the reagent holding bag 10. Comparing the reagent holding bag 10 and the reagent holding bag 110, the lengths of the reagent holding bag 10 in the A direction (front-to-back direction) L1, the lengths of the reagent holding bag in the B direction (thickness) W1, and the lengths of the reagent holding bag in the Z direction (vertical direction) H1 are all greater than the lengths of the reagent holding bag 110 in the A direction L2, the lengths of the reagent holding bag in the B direction W2, and the lengths of the reagent holding bag in the Z direction H2. On the other hand, reagent containers 100 and 200 both have frame members 23 of the same shape and size, and have a partially common structure. By using the same frame member 23 in reagent containers 100 and 200, the number of components can be reduced, and the positional constraint structure of reagent containers 100 and 200 in reagent container holding section 251 can be generalized. In reagent container 100, the length W1 in the B direction of reagent holding bag 10 is greater than the length in the B direction of frame member 23, but in reagent container 200, the length W2 in the B direction of reagent holding bag 110 is less than the length in the B direction of frame member 23. Hereinafter, refer to Figures 9-11 This describes the general structure of the sample analysis device 300. Figure 9 This is a three-dimensional view of the sample analysis device 300. Figure 10This is a schematic diagram illustrating the general structure of the sample analysis apparatus 300. For ease of explanation, the left-right direction of the sample analysis apparatus 300 will be designated as the X-direction, and the front-back direction (depth direction) of the sample analysis apparatus 300 will be designated as the Y-direction. Figure 9 and Figure 10 As shown, the sample analysis apparatus 300 includes a measurement unit 201, a sample conveying device 202 disposed on the front side (Y1 direction side) of the measurement unit 201, and an analysis unit 203 electrically connected to each measurement unit 201 and the sample conveying device 202 and composed of a computer (PC). Figure 9 and Figure 10 An example of a sample analysis apparatus 300 comprising two measurement units 201 arranged in the X direction is shown. The two measurement units 201 are designated as a first measurement unit 201a and a second measurement unit 201b. The second measurement unit 201b can perform analyses of different parameters than the first measurement unit 201a. Each measurement unit 201 has a unit cover 206 that internally houses the measurement mechanism. A reagent suction section 250 is disposed inside the unit cover 206. A closable front cover 206a is provided on the front side of the unit cover 206. The reagent suction section 250 is disposed on the upper front part of the measurement unit 201 and is exposed to the outside by opening the front cover 206a. This allows the user to easily insert reagent containers 100 and 200 into the reagent container holding section 251 of the reagent suction section 250 and to easily replace the reagent containers 100 and 200. The sample transport device 202 includes: a pre-analysis shelf holding section 202a, capable of holding multiple shelf 2 containing sample containers 1 for samples to be analyzed; a post-analysis shelf holding section 202b, capable of holding multiple shelf 2 containing sample containers 1 for samples to be analyzed; a shelf transport section 202c for horizontally moving the shelf 2 in the X direction; and a barcode reading section 205. The sample transport device 202 is configured to move the shelf 2 held in the pre-analysis shelf holding section 202a one by one onto the shelf transport section 202c. The sample transport device 202 is configured to place the sample containers 1 held on the shelf onto the shelf transport section 202c by transporting the shelf 2 on the shelf transport section 202c in the X direction to the receiving position 4b of the first measurement unit 201a for receiving the sample containers 1, the receiving position 4a of the second measurement unit 201b for receiving the sample containers 1, and the reading position 4c of the barcode reading section 205 for reading the barcode of the sample containers 1. Furthermore, the sample transfer device 202 is configured to move the analyzed shelf 2 from the shelf transfer section 202c to the analyzed shelf holding section 202b. The analysis unit 203 is composed of a computer (PC), mainly consisting of a control unit 203a (see reference) including a CPU, RAM, etc. Figure 10The analysis unit 203 is composed of a display unit 203b and an input device 203c. The display unit 203b displays the analysis results obtained by analyzing the digital signals sent from the first measurement unit 201a and the second measurement unit 201b. The analysis unit 203 is connected to the main computer 204. The control unit 203a includes a CPU, RAM, a solid-state drive, an input / output interface, and a communication interface. The CPU executes an application program, and the computer functions as the analysis unit 203. The control unit 203a controls the operation of each part of the first measurement unit 201a, the second measurement unit 201b, and the sample transport device 202. Furthermore, the solid-state drive and other components of the control unit 203a store a database of measurement results. The control unit 203a is configured to analyze particles in the measurement sample using the measurement results sent from the first measurement unit 201a and the second measurement unit 201b, and obtain analysis results (red blood cell count, platelet count, hemoglobin level, white blood cell count, etc.). Thus, the sample analysis apparatus 300 of this embodiment is a blood cell counting device that counts particles in a sample. For example... Figure 10 As shown, the measurement unit 201 (201a, 201b) includes a measurement control unit 210, a sample aspiration unit 220, a sample preparation unit 230, and a detection unit 240. The sample aspiration unit 220 has an aspiration needle 221 serving as a sample aspiration tube. The sample preparation unit 230 has a reagent pipette 252 for drawing reagent 12 from the reagent container 100, and prepares a measurement sample using the sample and reagent 12. The detection unit 240 detects signals corresponding to particles in the measurement sample. In this embodiment, the detection unit 240 detects signals corresponding to blood cells in the measurement sample, and the analysis unit 203 analyzes the detection signal from the detection unit 240 and counts the blood cells. The measurement control unit 210 includes a processor, a memory, a drive circuit, an input / output interface, and a communication interface. The measurement control unit 210 communicates with the control unit 203a of the analysis unit 203. The measurement control unit 210 controls the operation of each part in the measurement unit 201, such as the sample aspiration unit 220, the sample preparation unit 230, and the detection unit 240, based on the measurement instructions from the control unit 203a. The measurement control unit 210 outputs the information of the reagent 12 obtained from the reading unit 256 (described later) and the measurement results obtained from the detection unit 240 to the control unit 203a. Figure 11 This is a schematic diagram illustrating the general configuration of the sample analysis apparatus 300. (For example...) Figure 11As shown, the sample aspiration unit 220 includes an aspiration needle 221 and a metering unit 222. The tip of the aspiration needle 221 is formed to penetrate the sealing cap 1a of the sample container 1. Furthermore, the aspiration needle 221 is configured to move between the aspiration position from which the sample is aspirated from the sample container 1 and the reaction cell 231 (described later) via a motor. The metering unit 222 is configured as a syringe pump, which has the function of aspirating a predetermined amount of sample from the sample container 1 via the aspiration needle 221 and dispensing it into the reaction cell 231. The sample preparation unit 230 includes a reagent aspiration unit 250 for aspirating reagent 12 from the reagent container 100. Furthermore, the sample preparation unit 230 includes a reaction cell 231. The reaction cell 231 is configured to mix and react the sample (blood) aspirated by the sample aspiration unit 220 and the reagent 12 supplied from the reagent aspiration unit 250. Figure 11A reaction cell 231 is shown, but multiple reaction cells 231 are provided depending on the type of measurement. Various reagents 12 (staining solutions) corresponding to the measurement item are supplied to each reaction cell 231. Through the mixing and reaction process of the sample and reagents 12, measurement samples corresponding to various measurement items are prepared. Then, the prepared measurement samples are supplied to the detection unit 240. The sample preparation unit 230 includes a reagent pipette 252, a metering section 232 for quantitatively aspirating the reagent 12, and solenoid valves 233a and 233b for opening and closing the flow path when the aspirated reagent 12 is delivered to the metering section 232 and the reaction cell 231. The metering section 232 is composed of a syringe pump and a diaphragm pump, etc. Furthermore, the sample preparation unit 230 includes a metering section 234 and solenoid valves 235a and 235b for delivering reagents (hemolysin, diluent) from a large-capacity reagent container 3 disposed outside the measurement unit. With the reagent pipette 252 inserted into the reagent container 100, the quantitative unit 232 can draw a predetermined amount of reagent 12 from the reagent container 100 into the quantitative unit 232 by opening the solenoid valve 233a and closing the solenoid valve 233b. The quantitative unit 232 is configured to deliver a quantitatively measured amount of reagent 12 from within the quantitative unit 232 to the reaction cell 231 by closing the solenoid valve 233a and opening the solenoid valve 233b. The detection unit 240 includes an FCM measurement unit 241, which detects particles such as white blood cells (WBCs) in the sample using flow cytometry (FCM) with a light source. The measurement results obtained by the detection unit 240 are sent as sample measurement data (measurement results) to the analysis unit 203 by the measurement control unit 210. The analysis unit 203 analyzes each particle based on the light detected by the FCM measurement unit 241. The analysis unit 203 generates a scatter plot combining scattered light intensity and fluorescence intensity as parameters. Based on the distribution of the scatter plot, particles in the sample are classified, and the number of particles of each classified type is counted. Flow cytometry-based measurements include NEUT (neutrophils), LYMPH (lymphocytes), MONO (monocytes), EO (eosinophils), and BASO (basophils). Furthermore, the detection unit 240 performs detection based on sheath flow DC detection. The detection unit 240 allows particles such as cells to flow in a sheath fluid stream through a tiny opening, and a direct current flows between a pair of electrodes positioned opposite each other across the tiny opening. The detection unit 240 outputs the pulsed current change as particles pass through the tiny opening as the sheath flow DC detection results are presented. The analysis unit 203 counts each particle based on the current change. RBC (red blood cell) count is measured based on the sheath flow DC detection method. Additionally, the detection unit 240 performs HGB (hemoglobin) detection using the SLS-hemoglobin method. For a sample containing a hemolytic agent and the sample itself, the amount of transmitted light from the sample is obtained by irradiating it with a light source and passing through the light-receiving part.The detection unit 240 outputs the change in transmitted light intensity during the SLS-hemoglobin formation process as the detection result based on the SLS-hemoglobin method. The analysis unit 203 calculates and measures the hemoglobin concentration (HGB) in the sample based on the change in transmitted light intensity. As described above, the reagent aspiration unit 250 includes a reagent container holding part 251 for housing the reagent container 100, a reagent pipette 252, an operation unit 253, and a moving mechanism 254. The reagent pipette 252 passes through the sealing plug 21b of the reagent container 100 held in the reagent container holding part 251, aspirates the reagent 12 from the reagent receiving bag 10, and seals the opening 21a by the sealing body 252a. The upper end of the reagent pipette 252 is connected to the flow path leading to the quantitative unit 232 and the reaction cell 231. The operation unit 253 is configured to receive a prescribed operation from the user of the sample analysis device 300 for moving the reagent pipette 252. The moving mechanism 254 is linked to a predetermined operation received by the operating unit 253, causing the reagent container 100 and the reagent pipette 252 to move relative to each other. The moving mechanism 254 is configured to allow the reagent pipette 252 to enter into the reagent container 100 and to retract from the reagent container 100 via this relative movement. In the sample analysis apparatus 300, since the user does not need to insert the reagent pipette 252 into the opening 21a of the reagent container 100 before setting it, the reagent container 100 can be easily set into the sample analysis apparatus 300. (See reference.) Figures 12-23 The structure of the reagent suction section 250 is described in detail, especially the structure of the reagent container holding section 251 that houses the reagent containers 100 and 200. Figure 12 This is a three-dimensional view of reagent aspiration unit 249. (See diagram below.) Figure 12 As shown, the reagent aspiration unit 249 is composed of multiple reagent aspiration sections 250a to 250d. The reagent aspiration sections 250a to 250d are arranged side-by-side along the X direction with the operation section 253, which functions as a front cover, facing forward (Y1 direction) of the sample analysis device 300. Figure 12The diagram shows four reagent aspiration sections 250a to 250d, but the reagent aspiration unit 249 may have three or fewer, or five or more reagent aspiration sections 250a to 250d. An operating section 253 is disposed in front of each of the reagent aspiration sections 250a to 250d. The operating section 253 is configured to openably and closably cover the inlet of the reagent container holding section 251. The operating section 253 is configured so that a user can hold it and move it in the vertical direction (Z direction). A handle 253a protruding forward (Y1 direction) is formed on the operating section 253. The user can move the operating section 253 in the Z direction by holding the handle 253a and moving it in the Z direction. The reagent aspiration unit 249 includes a liquid storage tray 295. The liquid storage tray 295 is disposed at the bottom of the reagent aspiration unit 249 such that it covers the bottom of the reagent aspiration sections 250a to 250d. The liquid reservoir 295 has the function of catching reagent 12 in the event of leakage from reagent containers 100, 200 housed in the reagent container holding part 251. The liquid reservoir 295 can slide in the Y direction and be pulled out to the front of the device. Figure 13 This is a perspective view of the reagent suction unit 249, showing that the reagent pipette 252 of the reagent suction section 250a is in the rising position. Figure 14 It means in Figure 13 The diagram shows the state in which the reagent container 100 is housed in the reagent container holding section 251 of the reagent aspiration section 250a. (See diagram below.) Figure 13 and Figure 14As shown, the reagent container holding section 251 of reagent aspiration section 250a houses one reagent container 100. Reagent aspiration section 250b has the same structure as reagent aspiration section 250a and houses one reagent container 100. Reagent container holding sections 250c and 250d each house one reagent container 200 in their respective reagent container holding sections 251. Reagent aspiration sections 250a to 250d each include a reagent container holding section 251, a reagent pipette 252, and an operating section 253. On the other hand, compared to the reagent container holding sections 250a and 250b which house large-capacity reagent containers 100, the reagent container holding sections 251 of reagent aspiration sections 250c and 250d, which house small-capacity reagent containers 200, have smaller vertical length and width (X-direction length). In reagent suction sections 250c and 250d, a spacer 290 is provided to raise the position of the bottom surface of the reagent container holding section 251. The spacer 290 in reagent suction sections 250c and 250d ensures that the height of the opening 21a of the reagent container 200 is the same as the height of the opening 21a of the reagent container 100 provided in reagent suction sections 250a and 250b. This allows for consistent container insertion heights when setting each reagent container 100 and 200, facilitating setup operations. Furthermore, the other structures of reagent suction sections 250c and 250d are the same as those of reagent suction sections 250a and 250b. Hereinafter, the structure of reagent suction section 250a will be described as representative of reagent suction sections 250a to 250d. Reagent suction section 250a includes a lower base 255a and an upper base 255b, configured such that the upper base 255b can move vertically via operation of the operating section 253. The reagent suction unit 250a has a structure in which a reagent container holding part 251 is provided on the lower base 255a, a reagent pipette 252 and an operation part 253 are provided on the upper base 255b. Furthermore, the reagent suction unit 250a includes a moving mechanism 254 that allows the upper base 255b, on which the reagent pipette 252 is fixed, to move vertically. The reagent container holding part 251 is located at the lower part of the reagent suction unit 250a. The reagent container holding part 251 is provided on the lower base 255a and does not move vertically. The reagent container holding part 251 has a storage space 260 for storing a reagent container 100. The storage space 260 has an inlet opening towards the front (Y1 direction) of the reagent container holding part 251 and extends in the forward-backward direction (Y direction). The reagent container 100 is disposed within the storage space 260 such that the plug member 21 forming the opening 21a is located deep within the storage space 260. The storage space 260 of the reagent container holding part 251 is opened by the user pulling up the operating part 253 to move the upper base 255b upward. At this time, since the reagent pipette 252 also moves upward, the reagent container 100 can be inserted into the storage space 260.Since the reagent container 100 is inserted into the storage space 260 with the plug member 21 as the front end, the handle 25 is located near the entrance of the storage space 260 when the plug member 21 is inserted deep into the storage space 260. Therefore, it is not necessary to insert fingers deep into the storage space 260 when inserting the reagent container 100, and the handle 25 can be easily grasped when removing the reagent container 100 from the storage space 260. Details will be described later. The reagent container 100 is disposed in the storage space 260 with the reagent holding bag 10 suspended. The storage space 260 is a space divided by the first sidewall 351 and the second sidewall 352 facing each other in the X direction, and the bottom part 353 facing the bottom of the reagent holding bag 10 in the Z direction. Since the reagent holding bag 10 is disposed in the storage space 260 in a suspended state, the bottom of the reagent holding bag 10 does not contact the bottom part 353. The bottom portion 353 slopes from both sides towards the center in the width direction, making the central portion the deepest in the width direction. At the Y1 direction ends of the side walls 351 and 352 (the entrance end of the storage space 260), recesses 349 with decreasing wall height are formed. The recesses 349 are formed at a position opposite the handle 25 in the X direction when the reagent container 100 is positioned at the set position Ps of the reagent container holding portion 251. Therefore, even when the reagent container 100 is inserted deep into the reagent container holding portion 251, the handle 25 is easily grasped, and the reagent container 100 is easily removed from the reagent container holding portion 251. Figure 15 It means Figure 14 A diagram showing a portion of the BB line cross-section (a cross-section of the upper part of the reagent container holding section 251). (See diagram below.) Figure 15 As shown, the storage space 260 of the reagent container holding part 251 includes a first storage part 261 into which the reagent receiving bag 10 of the reagent container 100 is inserted, and a second storage part 262 disposed above the first storage part 261 into which the plug member 21 and the frame member 23 of the reagent container 100 are inserted. A guide groove 270 for guiding the frame member 23 is formed in the second storage part 262. By fitting the frame member 23 into the guide groove 270, the reagent container 100 is disposed in the storage space 260 in a suspended state. The first storage part 261 has side walls 351, 352 opposite to the wall sheet 11 of the reagent receiving bag 10 in the X direction. The first storage part 261 consists of side walls 351, 352 and a bottom part 353 (see reference). Figure 14 The space is divided to accommodate the entire reagent container bag 10. Additionally, a portion of the holding part 25 of the frame member 23 is housed in the first storage section 261. The second storage section 262 extends forward and backward (Y direction) from the inlet of the reagent container holding section 251, guiding the reagent container 100 to a set position Ps (see reference). Figure 1The guide groove 270 is formed with a depth (X-direction length) and width (Z-direction length) that allow the two ends of the frame member 23 to fit together in the width direction and allow the frame member 23 to slide, thus clamping the frame member 23 from both sides in the width direction. That is, a pair of guide grooves 270 are formed on both sides of the second storage part 262 in the X direction. Thus, even if the reagent container 100 has a reagent holding bag 10 that is easily deformable, it can be accurately guided to the set position Ps by the simple operation of the user inserting the reagent container 100 from the entrance of the storage space 260. The reagent container 100 is restricted in position by the frame member 23 abutting against the deep part of the guide groove 270, the left and right (both sides in the X direction), and the upper and lower groove walls, so that the reagent holding bag 10 is in a suspended state. The reagent container 100 is accurately positioned at the set position Ps by the front end 23a of the frame member 23 abutting against the deepest part of the guide groove 270. In other words, the guide groove 270 has a Y-direction length where the front end 23a abuts against the deepest part when the reagent container 100 is inserted into the set position Ps. The spacing between the opposing groove walls of the pair of guide grooves 270 in the X-direction is slightly larger than the width of the frame member 23. This limits the movement of the frame member 23 towards the second receiving portion 262 within permissible limits. Furthermore, the width (Z-direction length) of each guide groove 270 is slightly larger than the thickness (Z-direction length) of the frame member 23. Since the lower surface 23g of the frame member 23 is supported by the groove walls of the guide grooves 270, resulting in the reagent container 10 being suspended, the upper surface 23f of the frame member 23 does not contact the groove walls of the guide grooves 270. However, when the frame member 23 is lifted, the upper surface 23f abuts against the groove walls, and the frame member 23 is restricted from moving upwards beyond a predetermined permissible range. Figure 16 (A) is a diagram showing the state before the protruding member 273 and the frame member 23 engage with the cut 23c. Figure 16 (B) is a diagram representing the state after the cards are engaged. For example... Figure 16 (A) to Figure 16 As shown in (B), the reagent container holding portion 251 is provided with a pair of protruding members 273, which are pressed against both ends of the frame member 23 in the width direction and fitted into the cutouts 23c of the frame member 23. The pair of protruding members 273 are disposed within the guide grooves 270 to clamp the frame member 23 from both sides in the X direction. Each protruding member 273 is, for example, a V-shaped leaf spring, protruding from an opening 273a formed in the groove wall of the pair of guide grooves 270 toward the inside of the second receiving portion 262. Figure 16 As shown in (A), when the frame member 23 is inserted into the interior of the second receiving portion 262, each protruding member 273 is pushed outward of the second receiving portion 262 by abutting against the frame member 23. At this time, each protruding member 273 exerts force on the frame member 23 towards the inside of the second receiving portion 262 by the elastic force of the leaf spring. Figure 16 As shown in (B), when the reagent container 100 is positioned at the set position Ps, the cutouts 23c formed on the frame member 23 reach the positions of the protruding members 273. Consequently, each protruding member 273 enters the cutout 23c by the elastic force F of the leaf spring. As a result, unless an external force is applied that overcomes the elastic force F of the protruding members 273, the movement of the frame member 23 in the Y direction is restricted. By the protruding members 273 engaging with the cutouts 23c of the frame member 23, the frame member 23 can be kept in place so that the opening 21a of the reagent container 100 does not move from the set position Ps. Furthermore, since the frame member 23 remains stationary at the set position Ps when the reagent container 100 is inserted into the storage space 260, the user can perceive by touch that the reagent container 100 has been positioned correctly, even without visually confirming its position. Furthermore, since the frame member 23 is subjected to elastic forces F from both sides of each protruding member 273 in the X direction, the frame member 23 is positioned in the center of the second storage portion 262 in the X direction. Figure 17 This is a cross-sectional view of the reagent suction section 250a, showing the state in which the reagent container 100 is housed in the reagent container holding section 251 and the reagent pipette 252 is in the raised position. Figure 18 This diagram shows the reagent pipette 252 in the descending position. (See diagram below.) Figure 17 and Figure 18 As shown, the reagent pipette 252 is positioned above the deep side (Y2 direction end) of the reagent container holding part 251, with its tip facing downwards. The reagent pipette 252 is fixed to the upper base 255b and moves in the vertical direction (Z direction) by the moving mechanism 254. The reagent pipette 252... Figure 18 At the lowered position P2 shown, the reagent container 10 can be accessed through the opening 21a of the plug member 21 of the reagent container 100 to draw in the reagent holding bag 10 and aspirate the reagent 12. At this time, the sealing body 252a provided on the reagent pipette 252 abuts against the periphery of the opening 21a, sealing the reagent holding bag 10. As described above, the sealing body 252a is made of elastically deformable rubber. In addition, the sealing body 252a is made of a solid material that is not airtight. In the sealing body 252a, no vent hole is formed to communicate the opening 21a with the outside when the opening 21a is sealed. In addition, a force-applying member 252b is provided between the sealing body 252a and the pipette holding part 254a that holds the reagent pipette 252 to apply force to press the sealing body 252a against the opening 21a. The force-applying member 252b is, for example, a compression spring. The moving mechanism 254 holds the reagent pipette 252 so that it can move... Figure 17 The rising position P1 shown is... Figure 18The drop position P2 shown moves along the vertical direction (Z direction). The moving mechanism 254 includes a pipette holding part 254a and a linear motion mechanism composed of a linear guide rail 254b and a fixed slider 254c. The pipette holding part 254a is connected to the upper end of the linear guide rail 254b via a connecting part 254d extending in the Y direction. The linear guide rail 254b is positioned in front of the reagent aspiration part 250a and extends in the Z direction. The fixed slider 254c is fixed to the lower base 255a, holding the linear guide rail 254b so that it can move in the Z direction. Thus, the linear guide rail 254b moves in the Z direction relative to the fixed slider 254c. As the linear guide rail 254b moves in the Z direction, the reagent pipette 252 moves integrally with the linear guide rail 254b in the Z direction. Figure 17 As shown, the rising position P1 is when the reagent pipette 252 is completely retracted above the reagent container 100 positioned at the set position Ps. When the reagent pipette 252 is in the rising position P1, the reagent container 100 can be removed from the reagent container holding part 251, or the reagent container 100 can be inserted into the reagent container holding part 251. Figure 18As shown, the descending position P2 is the position where the reagent pipette 252 is inserted into the reagent holding bag 10 through the opening 21a of the reagent container 100. When the reagent pipette 252 is in the descending position P2, the tip of the reagent pipette 252 is located near the inner surface of the bottom of the bag inside the reagent holding bag 10. The moving mechanism 254 holds the operating part 253, causing the reagent pipette 252 to move in conjunction with the operating part 253. The operating part 253 is provided in front of the reagent suction part 250a, and the back side (Y2 direction side) of the operating part 253 is mounted on the linear guide rail 254b. Thus, by simply moving the operating part 253 up and down, the insertion of the reagent pipette 252 into the reagent container 100 and the retraction of the reagent pipette 252 out of the reagent container 100 can be performed. The operating part 253 is configured to move between a removal position Q1, which allows the reagent container 100 to be removed from the reagent container holding part 251, and a removal prevention position Q2, which prevents the reagent container 100 from being removed from the reagent container holding part 251. The removal position Q1 is the upward position of the operating section 253 when the reagent pipette 252 is in the upward position P1. The removal prevention position Q2 is the downward position of the operating section 253 when the reagent pipette 252 is in the downward position P2. Furthermore, if the user attempts to move the operating section 253 downward without correctly inserting the reagent container 100 into the set position Ps, the operating section 253 may come into contact with the holding part 25 of the reagent container 100, preventing the operating section 253 from moving to the removal prevention position Q2. Additionally, the reagent suction section 250a has a fixing pin 280 that descends in conjunction with the movement of the reagent pipette 252 caused by the moving mechanism 254. The fixing pin 280 is configured to enter the through hole 23d formed in the frame member 23 at least when the reagent pipette 252 is inserted into the opening 21a, fixing the position of the opening 21a. This prevents the reagent container 100 from accidentally moving when the reagent pipette 252 is inserted into the opening 21a. Therefore, it is possible to prevent the reagent container bag 10 from being unsealed or the reagent 12 from leaking out due to the positional displacement of the opening 21a. When the reagent pipette 252 is in the lowered position P2, the fixing pin 280 passes through the through hole 23d of the frame member 23, and the front end of the fixing pin 280 is inserted into the fixing hole 281 formed in the bottom part 353 of the reagent container holding part 251. As a result, when the reagent pipette 252 is in the lowered position P2, the frame member 23, which abuts against the fixing pin 280 in the through hole 23d, becomes immobile in the horizontal direction, and the position of the opening 21a can be more reliably fixed. The reagent suction part 250a also has a reading part 256 for obtaining information about the reagent 12 from the information recording medium 28 provided on the frame member 23. The reading part 256 is provided at the upper part of the reagent container holding part 251, along the path through which the information recording medium 28 passes, or at a position opposite to the information recording medium 28 in the vertical direction when the reagent container 100 is positioned in the set position Ps.Therefore, when the reagent container 100 is inserted into the reagent container holding part 251, the reading unit 256 can read information about the reagent 12 from the information recording medium 28. The reading unit 256 is, for example, an RFID reader that wirelessly communicates with the information recording medium 28, which is composed of RFID tags, and reads information from the information recording medium 28. The information about the reagent 12 read by the reading unit 256 includes various information such as the type of reagent 12, batch number, and shelf life. The analysis unit 203 acquires the information about the reagent 12 read from the information recording medium 28 by the reading unit 256 via the measurement control unit 210, and performs processing based on the acquired information about the reagent 12. The analysis unit 203, for example, manages the shelf life of the reagent 12. Figure 19 (A) is a cross-sectional view showing the state of the reagent container 100 before the opening 21a is sealed by the sealing body of the reagent pipette. Figure 19 (B) is a cross-sectional view showing the sealed state (B). For example... Figure 19 As shown in (A), during the downward movement of the reagent pipette 252, the sealing body 252a disposed on the reagent pipette 252 is pressed against the periphery of the opening 21a. After the reagent pipette 252 moves downward via the moving mechanism 254 and the sealing body 252a contacts the periphery of the opening 21a, the reagent pipette 252 moves further downward to the predetermined descending position P2. The reagent pipette 252 moves while compressing the force-applying member 252b. Figure 19 As shown in (B), at the descending position P2 of the reagent pipette 252, the force-applying member 252b is compressed, and the force-applying member 252b applies force to press the sealing body 252a against the opening 21a. As a result, the sealing body 252a elastically deforms and seals against the periphery of the opening 21a, thus sealing the opening 21a more reliably. Figure 20 This is a cross-sectional view of the reagent container holding portions 251a to 251d of the reagent aspiration unit 249, horizontally cut along the Y direction (front-back direction / depth direction). (See figure) Figure 20As shown, the reagent aspiration unit 249 includes multiple reagent container holding sections 251a to 251d. As described above, the reagent container holding sections 251a to 251d respectively constitute reagent aspiration sections 250a to 250d, each housing one reagent container 100 or reagent container 200. Reagent container holding sections 251a and 251b house large-capacity reagent containers 100, while reagent container holding sections 251c and 251d house small-capacity reagent containers 200. The storage spaces 260a and 260b of the reagent container holding sections 251a and 251b are larger than the storage spaces 260c and 260d of the reagent container holding sections 251c and 251d, but since each reagent container 100 and 200 uses the same frame member 23, the depth length of each storage space is the same. In the storage spaces 260a and 260b of the reagent container holding portions 251a and 251b, the width (X-direction length) of the first storage portions 261a and 261b that serve as the portion for storing the reagent container bag 10 is greater than the width of the first storage portions 261c and 261d that serve as the portion for storing the reagent container bag 110 in the storage spaces 260c and 260d of the reagent container holding portions 251c and 251d. The width of the reagent container bag 110 of the reagent container 200 is less than the width of the frame member 23 (see reference). Figure 7 (B)), but the reagent container 10 of the reagent container 100 expands significantly beyond both ends of the frame member 23 in the width direction (see reference). Figure 7(A) Therefore, the first receiving portions 261a and 261b need to be wider than the first receiving portions 261c and 261d. The reagent container holding portions 251a and 251b can also hold small-capacity reagent containers 200. Therefore, all reagent container holding portions can be made to accommodate large-capacity reagent containers 100, but from the viewpoint of miniaturizing the sample analysis apparatus 300, it is preferable to provide reagent container holding portions 251c and 251d dedicated to small-capacity reagent containers 200, since the use of reagent containers 200 is anticipated to some extent. The reagent container holding portions 251a and 251b have the same structure as each other. In addition, the reagent container holding portions 251c and 251d have the same structure as each other. Hereinafter, the structure of the reagent container holding portion 251a will be described as a representative of the reagent container holding portions 251a and 251b. In addition, the structure of the reagent container holding portion 251c will be described as a representative of the reagent container holding portions 251c and 251d. As described above, the reagent container holding portion 251a has side walls 351 and 352 facing each other in the X direction, and a bottom portion 353 connecting the lower ends of the side walls 351 and 352 to each other. The reagent container holding portion 251a also has a rear wall 354 connecting the side walls 351 and 352 to each other at the deepest part of the first storage portion 261a. The first storage portion 261a is a space divided by the side walls 351 and 352, the bottom portion 353, and the rear wall 354, capable of accommodating the entire reagent container bag 10. In the first storage portion 261a, the reagent container bag 10 is suspended and stored without contacting the bottom portion 353. That is, the reagent container holding portion 251a is configured to hold the reagent container 100 without the bottom of the reagent container bag 10 being supported from below. Since the reagent container bag 10 is a flexible packaging material container, it would deform significantly due to its own weight if placed on the bottom portion 353, but this deformation can be suppressed by suspending the reagent container bag 10. Furthermore, inserting the reagent container 10 into the first storage section 261a becomes smooth. The bottom surface 353 has a gap between itself and the bottom of the reagent container 10, and is positioned vertically opposite the bottom of the reagent container 10. Additionally, the surface of the bottom surface 353 opposite the bottom of the reagent container 10 is inclined such that the central portion is deeper than the two ends of the bottom surface 353 in the width direction. Similarly, the side wall 352 is configured with a gap between itself and the surface of the reagent container 10, just like the bottom surface 353. Inserting the reagent container 10 into the first storage section 261a becomes smooth by ensuring that the reagent container 10 does not contact the side wall 352. On the other hand, the side wall 351 is configured to actively contact the reagent container 10. Details will be described later; the side wall 351 has a pressing portion 350 for sealing the reagent container 10 by pressing the opening 21a from the outside. The reagent container holding part 251a has side walls 351 and 352 arranged opposite to the surface of the reagent holding bag 10 on both sides in the thickness direction, and a pressing part 350 is formed on the side wall 351.The pressing part 350 corrects the shape of the reagent container bag 10, preventing it from being positioned at the set position Ps in a significantly deformed state, effectively suppressing damage to the reagent container bag 10 caused by puncture from the reagent pipette 252. Similar to the reagent container holding part 251a, the reagent container holding part 251c has side walls 355 and 356 facing each other in the X direction, a bottom part 357 connecting the lower ends of the side walls 355 and 356, and a rear wall 358 connecting the side walls 355 and 356 to each other at the deepest part of the first storage part 261c. The first storage part 261c is a space divided by the side walls 355 and 356, the bottom part 357, and the rear wall 358, capable of accommodating the entire reagent container bag 110. In the first storage part 261c, the reagent container bag 110 is suspended and stored without contacting the bottom part 357. That is, the reagent container holding part 251c is configured to hold the reagent container 200 without the bottom of the reagent holding bag 110 being supported from below. Since the reagent holding bag 110 is a flexible packaging material container, it would deform significantly due to its own weight if placed on the bottom part 357, but the deformation of the reagent holding bag 110 can be suppressed by suspending the reagent holding bag 110. In addition, it becomes smooth to insert the reagent holding bag 110 into the first storage part 261c. The surface of the bottom part 357 opposite to the bottom of the reagent holding bag 110 can be inclined so that the central part is deeper than the two ends in the width direction of the bottom part 357. The side walls 355 and 356 are arranged with a gap between them and the reagent holding bag 110, just like the bottom part 357. It becomes smooth to insert the reagent holding bag 110 into the first storage part 261c by not contacting the side walls 355 and 356. Unlike the reagent container holding portion 251a, which has a pressing part 350, the reagent container holding portion 251c differs in that its opposing sidewalls 355 and 356 in the X direction are configured not to contact the reagent holding bag 110. The small-capacity reagent holding bag 110 is a flat bag made of two sheets, which easily returns to its original shape under its own weight even if deformed. Therefore, shape correction via the pressing part 350 is unnecessary, and the sidewalls 355 and 356 do not contact the reagent holding bag 110. Similarly, in the first storage portion 261c, the pressing part 350 can also be formed on either of the sidewalls 355 and 356, just as in the first storage portion 261a. Furthermore, the depth side of the first storage portion 261a of the reagent container holding portion 251a is narrower than the inlet side, while the first storage portion 261c of the reagent container holding portion 251c has a certain width from the inlet to the depth. The inlet side is defined as the range between the inlet of the first storage portion 261a and the center position Py in the depth direction. The deep side (rear side) is defined as the range between the center position Py in the depth direction of the first storage section 261a and the deepest position of the first storage section 261a. Figure 21 and Figure 22 This is a cross-sectional view of the reagent container holding section 251a. Figure 22This indicates that the reagent container bag 10 is stored in the first storage section 261a. For example... Figure 21 and Figure 22As shown, the sample analysis apparatus 300 includes a pressing portion 350 in the reagent container holding portion 251a for pressing the reagent receiving bag 10 sealed by pressing the opening 21a from the outside. The pressing portion 350 deforms the reagent receiving bag 10 by pressing it from the outside, causing the internal pressure of the reagent receiving bag 10 to become higher than before it was placed in the reagent container holding portion 251a. That is, the pressing portion 350 increases the internal pressure of the reagent receiving bag 10 by pressing it from the outside when it is inside the reagent container holding portion 251a, thereby deforming the reagent receiving bag 10. The pressing portion 350 is part of the reagent container holding portion 251a and is formed as part of the inner surface of the side wall 351. The inner surface of the side wall 351 refers to the surface facing the inside of the first receiving portion 261a and opposite the wall sheet 11 of the reagent receiving bag 10. Because the reagent container 10 is pressed from the outside with the opening 21a sealed by the sealing plug 21b, the reagent 12 and internal air are not squeezed out from the opening 21a, causing the internal pressure of the reagent container 10 to rise and its shape to be corrected. Since the reagent container 10 is made of flexible packaging material, it is easily deformed. For example, it is conceivable that the wall sheet 11 may deform inwards towards the inside of the reagent container 10 near the opening 21a where the reagent pipette 252 is inserted. If the reagent container 100 is positioned at the set position Ps with the reagent container 10 in such a deformed state, and the reagent pipette 252 is inserted from the opening 21a, the tip of the reagent pipette 252 may come into contact with the wall sheet 11. If the tip of the reagent pipette 252 contacts the wall sheet 11, the wall sheet 11 may rupture, causing the reagent 12 to leak out. Therefore, the reagent container 100 should be positioned at the set position Ps without such deformation. Specifically, at the set position Ps, it is necessary to ensure that the wall sheet 11 is not deformed at the position where the reagent pipette 252 passes through the reagent container 10. Since the reagent container 10 is easily deformable, its shape can be easily corrected by pressing it from the outside. That is, even if the wall sheet 11 is significantly concave near the opening 21a, by pressing the reagent container 10 from the outside at a position different from the concave portion, the concave portion of the wall sheet 11 can be expanded outwards, and the shape of the reagent container 10 can be corrected by causing the wall sheet 11 to retract from the position where the reagent pipette 252 passes. Details will be described later. The reagent container 100 is treated as a reagent kit 450 protected by the protective member 460 to suppress deformation of the reagent container 10 during transportation or storage; however, it is also contemplated that the reagent container 10 may deform after being removed from the protective member 460. Therefore, it is preferable to transport the reagent container 100 in the state of reagent kit 450 to suppress deformation of the reagent holding bag 10, and a pressing part 350 is provided in the reagent container holding part 251a to correct the shape of the reagent holding bag 10.The reagent container holding portion 251a has a pressing portion 350 only on the sidewalls 351 and 352, which are arranged opposite to the surface of the reagent container bag 10 in the thickness direction. When the reagent container 100 is inserted into the reagent container holding portion 251a with the opening 21a side as its front end, the wall sheet 11 of the reagent container bag 10 contacts the pressing portion 350 formed on the sidewall 351. If the reagent container 100 is further inserted into the reagent container holding portion 251a from this position, the reagent container bag 10 is pressed inward by the reaction force from the pressing portion 350, increasing the internal pressure and correcting the shape of the reagent container bag 10. That is, the pressing portion 350 presses the reagent container bag 10 from the outside when the reagent container 100 is moved relative to the reagent container holding portion 251a to insert it into the reagent container holding portion 251a. The pressing portion 350 presses a position offset from below the opening 21a of the reagent container bag 10. The reagent container 10, pressed by the pressing part 350, expands on the outer side below the opening 21a. That is, by inserting the reagent container 100 into the reagent container holding part 251a, the shape of the reagent container 10 is naturally corrected. Therefore, damage to the reagent container 10 caused by the reagent pipette 252 can be effectively suppressed without forcing the user to perform special work such as adjusting the shape of the reagent container 10. In addition, since the reagent container 10 contains the reagent 12 and is heavy, when the reagent container 10 is pressed by the pressing part 350, the reagent container 10 as a whole does not move towards the side wall 352, but is pressed inward, and the internal pressure increases. The pressing part 350 is formed on the inner surface of the side wall 351 opposite to the wall sheet 11 at a position where the wall sheet 11 can contact before the reagent container 100 reaches the set position Ps. That is, the pressing part 350 does not first contact the wall sheet 11 when the reagent container 100 is inserted into the set position Ps, but rather contacts the wall sheet 11 and presses the reagent receiving bag 10 while the reagent container 100 is moving to the set position Ps. Therefore, the end of the pressing part 350 on the inlet side of the first receiving part 261a (hereinafter referred to as the "starting end of the pressing part 350") is preferably located closer to the inlet side than the center of the first receiving part 261a in the depth direction (Y direction). Hereinafter, except... Figure 21 and Figure 22 In addition, refer to appropriately Figure 23 . Figure 23 From Figure 21 The diagram shows the inner surface portions of the side walls 351, 352 and the rear wall 354. Figure 23As shown, the pressing part 350 is formed on the inner surface of the side wall 351 within a predetermined length Ly of the depth center position Py of the first receiving part 261a. The predetermined length Ly along the depth direction of the first receiving part 261a is, for example, a length range of 25% to 45% of the depth direction length L of the first receiving part 261a. If the pressing part 350 is formed at the entrance of the first receiving part 261a, narrowing the entrance, it is envisioned that it would hinder the insertion of the reagent container 100; therefore, the beginning of the pressing part 350 is preferably at a depth of a predetermined length from the entrance. The length Ld from the entrance of the first receiving part 261a to the beginning of the pressing part 350 is, for example, 25% to 40% of the depth direction length L of the first receiving part 261a. Furthermore, even if the pressing part 350 is formed near the deepest part of the first receiving part 261a, the wall sheet 11 does not contact it, making it impossible to correct the shape of the reagent container bag 10. Therefore, the end of the pressing portion 350 (hereinafter referred to as the "terminal of the pressing portion 350") on the deep side of the first storage portion 261a is located away from the rear wall 354 of the first storage portion 261a. The length Le from the rear wall 354 to the terminal of the pressing portion 350 is, for example, more than 25% and less than 40% of the depth length L of the first storage portion 261a. As described above, the pressing portion 350 is formed only on the side wall 351 and not on the side wall 352 opposite to the side wall 351. The side wall 352 is spaced apart from the surface of the reagent container bag 10. Although the pressing portion 350 can also be formed on both the side walls 351 and 352, by forming the pressing portion 350 only on the side wall 351, the shape of the reagent container bag 10 can be modified more smoothly. If pressing portions 350 are formed on both side walls 351 and 352, the resistance when inserting the reagent container 100 will increase, potentially hindering smooth insertion. Furthermore, pressing the reagent holding bag 10 from one side makes it easier for the reagent 12 inside the bag to move, allowing for rapid correction of the shape of the reagent holding bag 10. The following, except... Figures 21-23 In addition, refer to appropriately Figure 24 . Figure 24 This is a perspective view of the inner surface of the sidewall 351 on which the pressing part 350 is formed. For example... Figures 21-24As shown, the sidewall 351, serving as a pressing portion 350, includes a slope that is inclined relative to the depth direction of the first receiving portion 261a, such that it gradually approaches the sidewall 352 from the entrance side of the first receiving portion 261a toward the depth side. The slope is formed so that, when the reagent container 10 is received in the first receiving portion 261a, it is closer to the entrance side of the first receiving portion 261a than the opening 21a of the reagent container 100. In other words, the sidewall 351, serving as a pressing portion 350, includes an inclined portion that is inclined relative to the insertion direction of the reagent container 100 into the internal space of the first receiving portion 261a. The inclined portion is formed between the entrance of the internal space and the internal region of the internal space (the location of the opening 21a). In the region of the inclined portion, the sidewall 351 gradually approaches the sidewall 352 toward the internal region of the internal space. The aforementioned inclined surface of the sidewall 351 includes: a first inclined surface 351a; and a second inclined surface 351b, which is formed between the inner region of the first receiving portion 261a (the location of the opening 21a) and the first inclined surface 351a, and whose inclination angle relative to the depth direction of the first receiving portion 261a is smaller than that of the first inclined surface 351a. In other words, the inclined portion includes a first inclined portion (first inclined surface 351a) and a second inclined portion (second inclined surface 351b). The first inclined portion is disposed between the entrance and the second inclined portion. The first inclined surface 351a extends straight at a certain angle relative to the depth direction of the first receiving portion 261a from the boundary position with the entrance side region 351d to the boundary position with the middle region 351c. Similarly, the second inclined surface 351b extends straight at a certain angle relative to the depth direction of the first receiving portion 261a from the boundary position with the middle region 351c to the boundary position with the deep side region 351e. On the inner surface of the sidewall 351, an intermediate region 351c is formed between the first inclined surface 351a and the second inclined surface 351b, extending along the depth direction of the first receiving portion 261a. In other words, the first sidewall 351 includes a region (intermediate region 351c) parallel to the insertion direction of the reagent container 100 between the first inclined portion (first inclined surface 351a) and the second inclined portion (second inclined surface 351b). The first inclined surface 351a, the second inclined surface 351b, and the intermediate region 351c function as a pressing portion 350 that presses the reagent receiving bag 10 from the outside and corrects the shape of the bag. The inner surface of the sidewall 351 includes an entrance-side region 351d located closer to the entrance of the first receiving portion 261a than the beginning of the pressing portion 350, and a deep-side region 351e located deeper than the end of the pressing portion 350 than the depth of the first receiving portion 261a, but these regions do not contact the reagent receiving bag 10. The inlet side region 351d and the deep side region 351e extend parallel to the depth direction of the first receiving part 261a and are configured to have a predetermined gap between the reagent container 100 and the reagent receiving bag 10 when the reagent container 100 is positioned at the set position Ps.Furthermore, although the reagent container 10 does not contact the boundary position between the first inclined surface 351a and the inlet-side region 351d, and in the vicinity thereon, this boundary position is used as the starting point of the pressing part 350. The first inclined surface 351a protrudes significantly towards the side wall 352, pressing the reagent container 10 forcefully. The reagent container 10 is forcefully squeezed by the first inclined surface 351a on the inlet side, and its shape is significantly modified. The second inclined surface 351b protrudes less than the side wall 351, so the force pressing the reagent container 10 is weaker than that of the first inclined surface 351a, which helps to adjust the shape of the reagent container 10. The first inclined surface 351a and the second inclined surface 351b can be continuous, but by forming an intermediate region 351c between the two inclined surfaces, especially by significantly bending the inner surface of the side wall 351 at the boundary position between the first inclined surface 351a and the intermediate region 351c, an angle 351f is formed at the boundary position. Angle 351f, formed at the boundary between the first inclined surface 351a and the intermediate region 351c, protrudes towards the side wall 352 and strongly abuts against the wall sheet 11 of the reagent container 10. When the reagent container 100 is inserted into the inlet of the first receiving portion 261a, the wall sheet 11 contacts the first inclined surface 351a and is pressed, then contacts the angle 351f and is further pressed. Through the strong pressure from the first inclined surface 351a and angle 351f, which protrude significantly inwards from the first receiving portion 261a, the deformation of the reagent container 10 is effectively corrected. The first inclined surface 351a and angle 351f are integrally formed on the inlet side of the first receiving portion 261a. In this case, as the reagent container 100 moves to the set position Ps of the reagent container holding portion 251a, the wall sheet 11 contacts the first inclined surface 351a and angle 351f and is pressed, thus correcting the shape of the reagent container 10. The first inclined surface 351a and angle 351f press against the central portion of the reagent container 10, which has expanded significantly, causing the internal pressure to rise. Therefore, even if the front end of the reagent container 10 is deformed, the reagent 12 will flow to the front end of the bag, and the wall sheet 11 will be pushed to the outside of the reagent container 10. The second inclined surface 351b is formed entirely in the deep side of the first receiving portion 261a, for example, to further correct the shape of the reagent container 10 that could not be completely corrected by the first inclined surface 351a, or to apply appropriate pressing pressure to maintain the corrected shape. The second inclined surface 351b has the function of adjusting the shape of the reagent container 10 near the opening 21a. The angle 351g formed at the boundary between the second inclined surface 351b and the deep side region 351e is an angle that protrudes in the direction of the side wall 352, and strongly abuts against the wall sheet 11 of the reagent container 10. Therefore, if the reagent container 100 is inserted from the inlet of the first receiving part 261a, for example, the wall sheet 11 contacts the second inclined surface 351b and is pressed, and then contacts the angle 351g and is pressed further, but the protrusion of the angle 351g is smaller than that of the angle 351f.The reagent container 10 is preliminarily corrected, for example, by angle 351g, and its shape is adjusted. The intermediate region 351c is parallel to the depth direction of the first receiving portion 261a, and the distance between the intermediate region 351c and the side wall 352 is shorter than the distance between the inlet side region 351d and the side wall 352. It contacts and presses the reagent container 10, thus functioning as a pressing portion 350 to correct the shape of the reagent container 10. In particular, the intermediate region 351c is important for forming a steep angle 351f at the boundary with the first inclined surface 351a. By not making the first inclined surface 351a continuous with the second inclined surface 351b, but rather intermediate in the intermediate region 351c, a multi-step pressing portion 350 containing the steep angle 351f is formed on the inner surface of the side wall 351. Thus, the shape correction effect of the reagent container 10 is improved. Figure 23As shown, the inclination angle θ1 of the first inclined surface 351a relative to the depth direction of the first storage portion 261a is, for example, 15° or more and 30° or less, more preferably 15° or more and 25° or less. Furthermore, the length La of the first inclined surface 351a along the depth direction is, for example, 8% or more and 20% or less of the depth direction length L of the first storage portion 261a, more preferably 10% or more and 15% or less. In this case, the first inclined surface 351a and angle 351f have a more significant effect on correcting the shape of the reagent container bag 10. The inclination angle θ2 of the second inclined surface 351b relative to the depth direction of the first storage portion 261a is smaller than the inclination angle of the first inclined surface 351a. In other words, the angle (θ2) between the insertion direction (depth direction) and the inclination of the second inclined portion (second inclined surface 351b) is smaller than the angle (θ1) between the insertion direction (depth direction) and the inclination of the first inclined portion (first inclined surface 351a). The tilt angle θ2 can be, for example, 30% or more and 70% or less of the angle θ1, more preferably 40% or more and 60% or less. Furthermore, the length Lb of the second inclined surface 351b along the depth direction is, for example, shorter than the length La of the first inclined surface 351a, being 5% or more and 15% or less of the depth direction length L of the first receiving portion 261a. In this case, the shape correction effect of the second inclined surface 351b and the angle 351g is more significant. The length Lc of the intermediate region 351c along the depth direction is, for example, 8% or more and 20% or less of the depth direction length L of the first receiving portion 261a. In this embodiment, the intermediate region 351c is located at and around the center position Py of the first receiving portion 261a in the depth direction. The distance W2R from the center position Px in the width direction of the first storage section 261a to the intermediate region 351c along the X direction is smaller than the distance W2L from the center position Px in the width direction to the region of the sidewall 352 opposite to the intermediate region 351c along the X direction, for example, more than 10% smaller. A preferred example of the ratio of distance W2R to distance W2L (W2R / W2L) is 60% or more and 85% or less, or 65% or more and 80% or less. In this case, the shape of the reagent storage bag 10 can be more effectively corrected while preventing the reagent storage bag 10 from contacting the sidewall 352. In this embodiment, the distance W3R from the center position Px in the width direction to the inlet side region 351d along the X direction is substantially the same as the distance W3L from the center position Px in the width direction to the region of the sidewall 352 opposite to the inlet side region 351d along the X direction. The side wall 352 is formed along the depth direction from the entrance of the first storage part 261a to the position opposite the second inclined surface 351b in the X direction, and gradually slopes inward toward the rear wall 354 from the position opposite the second inclined surface 351b.Furthermore, in the deepest part of the first storage section 261a, the distance W0R from the center position Px in the width direction to the deep side region 351e along the X direction is substantially the same as the distance W0L from the center position Px in the width direction to the area of the side wall 352 opposite to the deep side region 351e along the X direction. At and near the entrance of the first storage section 261a, the X-direction lengths from the center position Px in the width direction to the side walls 351 and 352 are equal. The spacing between the side walls 351 and 352 at the entrance of the first storage section 261a is, for example, more than 103% and less than 110% of the maximum thickness of the reagent container bag 10, and in one example, more than 35 mm and less than 50 mm. Additionally, in the deepest part of the first storage section 261a, the X-direction lengths from the center position Px in the width direction to the side walls 351 and 352 are also equal. In one example, the spacing between the side walls 351 and 352 in the deepest part of the first storage section 261a is more than 20 mm and less than 28 mm. The distance W1R from the center position Px in the width direction of the first storage section 261a to the deep side region 351e along the X direction is, for example, more than 30% smaller than the maximum value of the distance W1L from the center position Px in the width direction to the region of the sidewall 352 opposite to the deep side region 351e along the X direction. A preferred example of the ratio of the maximum value of distance W1R to distance W1L (W1R / W1L) is 30% or more and 70% or less. Since the region of the sidewall 352 opposite to the deep side region 351e gradually slopes towards the rear wall 354 and closer to the sidewall 351, W1R / W1L gradually decreases as it approaches the rear wall 354. The first storage section 261a narrows towards the depth, but the reagent container 10 is tapered towards the front end, so the reagent container 10 does not contact the sidewall 352. Figure 24As shown, the pressing part 350 is formed along the vertical direction of the side wall 351 over approximately the entire length of the area opposite the reagent container bag 10. Since the upper and lower ends of the reagent container bag 10 are relatively thin, they are not easily accessible to the pressing part 350, but at least the portions away from the upper and lower ends of the reagent container bag 10 are in contact with and pressed by the pressing part 350. The first inclined surface 351a, the second inclined surface 351b, and the intermediate region 351c are formed with a certain width along the vertical direction of the side wall 351. The reagent container holding part 251a is constructed by assembling multiple components. For example, half of the side wall 351, half of the bottom part 353, and half of the rear wall 354 that divide the first storage part 261a are integrally formed by a first component. Furthermore, half of the side wall 352, half of the bottom part 353, and half of the rear wall 354 are integrally formed by a second component, which, when assembled with the first component, forms the first storage part 261a. Furthermore, as described above, a recess 349 is formed at the entrance end of the storage space 260 in the side walls 351 and 352 to reduce the wall height and facilitate gripping of the reagent container 100. The pressing portion that corrects the shape of the reagent container 10 only needs to be able to press the reagent container 10; it can be a gentle slope or a curved surface. However, if it is a gentle slope or a curved surface, for example, the internal pressure of the reagent container 10 will rise gradually, and the reagent 12 will not flow significantly. As a result, the shape correction effect of the pressing portion on the reagent container 10 may be reduced. As in this embodiment, by configuring a steep first slope 351a and providing multiple slopes or steps to form a stepped pressing portion 350 in the depth direction of the first storage portion 261a, the shape correction effect of the reagent container 10 becomes more significant. In particular, the pressing part 350, which consists of a first inclined surface 351a, a middle region 351c, and a second inclined surface 351b formed sequentially from the inlet side of the first storage section 261a, can effectively correct the shape of the reagent storage bag 10 while ensuring smooth insertion into the first storage section 261a. Hereinafter, refer to... Figure 13 , Figure 14 The following describes a method for housing the reagent container 100 within the reagent container holding section 251a, which has the aforementioned structure, in the reagent suction section 250a. First, the user opens the front cover 206a (see...). Figure 9 Holding the handle 253a of the reagent aspiration section 250, pull up the operating section 253 to move it to the extraction position Q1 (refer to...). Figure 17Thus, the entrance to the storage space 260a of the reagent container holding section 251a is opened. Additionally, the reagent pipette 252 moves to the rising position P1 as the operating section 253 moves to the removal position Q1. Next, the user holds the gripping part 25 of the frame member 23 of the reagent container 100 and inserts the reagent container 100 into the storage space 260a of the reagent container holding section 251a with the stop member 21 side as the front end. At this time, the two ends of the frame member 23 in the width direction are fitted into the guide groove 270 of the reagent container holding section 251a, and the frame member 23 can slide in the Y direction within the second storage section 262 of the storage space 260a. When the frame member 23 reaches the set position of the protruding member 273, the frame member 23 pushes the protruding member 273 outward in the X direction. Because the frame member 23 is subjected to force from both sides in the width direction by a pair of protruding members 273, the center position of the frame member 23 is aligned with the center of the second storage section 262 in the X direction. Then, the reagent container 100 is positioned at a set position Ps where the opening 21a is located directly below the reagent pipette 252, by the front end 23a of the frame member 23 abutting against the deepest part of the guide groove 270. At this time, a pair of protruding members 273 are engaged with the cutout 23c of the frame member 23, and the Y-direction movement of the frame member 23 is restricted. The reagent holding bag 10 of the reagent container 100 can slide in the Y-direction within the first storage portion 261a of the storage space 260a. The thickness of the plug member 21 side of the reagent holding bag 10 is small, and no pressing portion 350 is formed near the entrance of the first storage portion 261a. Therefore, for a period of time after the reagent holding bag 10 is inserted into the first storage portion 261a, the reagent holding bag 10 does not contact the pressing portion 350 formed on the side wall 351. Near the entrance of the first receiving section 261a, the reagent container 100 can be smoothly inserted due to the wide spacing between the side walls 351, 352 on both sides of the reagent container bag 10 in the X direction. When the front end of the reagent container bag 10 is inserted to a depth exceeding the center position Py in the depth direction of the first receiving section 261a, the wall sheet 11 of the reagent container bag 10 contacts the first inclined surface 351a of the pressing part 350 and is pressed from the outside of the reagent container bag 10. Since the reagent container bag 10 is pressed while the opening 21a is sealed by the sealing plug 21b, the reagent 12 and air are not squeezed out from the opening 21a, and the internal pressure of the reagent container bag 10 increases. As a result, for example, when the wall sheet 11 below the plug member 21 deforms to be recessed inward towards the reagent container bag 10, the wall sheet 11 below the plug member 21 is pushed outward by bulging, and the shape of the reagent container bag 10 is corrected. When the reagent container 10 is further inserted, it comes into contact with the angle 351f formed at the boundary between the first inclined surface 351a and the intermediate region 351c, and is subjected to stronger pressing pressure. At this time, the internal pressure of the reagent container 10 increases further, and the wall sheet 11 that is recessed inward toward the inside of the reagent container 10 is pushed outward.Since the first inclined surface 351a and the corner 351f are formed closer to the inlet side than the center of the first receiving portion 261a in the depth direction, the shape of the reagent container 10 can be sufficiently corrected before the reagent container 100 reaches the set position Ps. Before the reagent container 100 reaches the set position Ps, the reagent container 10 is further pressed by the middle region 351c of the pressing portion 350, the second inclined surface 351b, and the corner 351g formed at the boundary between the second inclined surface 351b and the deep side region 351e. Although the pressing force from the middle region 351c, the second inclined surface 351b, and the corner 351g is smaller than the pressing force from the first inclined surface 351a and the corner 351f, the shape of the reagent container 10 is adjusted and the corrected shape is maintained. In addition, since the side wall 352 is arranged away from the center of the width direction of the first receiving portion 261a, the reagent container 10 does not contact the side wall 352. Therefore, the insertion resistance of the reagent container 100 can be reduced, allowing for smooth insertion. The reagent holding bag 10 expands more on the side of the insertion corner sheet 13 disposed on the inlet side of the first storage section 261a than on the side of the opening 21a disposed deep within the first storage section 261a. Therefore, once the reagent holding bag 10 contacts the pressing part 350, the reagent holding bag 10 remains in contact with the pressing part 350 and is subjected to pressing pressure from the pressing part 350. The deformation of the reagent holding bag 10 that may be problematic is such that the wall sheet 11 is concave towards the inside of the reagent holding bag 10 near the opening 21a where the reagent pipette 252 is inserted. However, even when pressing the portion of the reagent holding bag 10 away from the opening 21a, the internal pressure increases, and the shape of the reagent holding bag 10 is corrected so that the wall sheet 11 near the opening 21a is pushed outward. Subsequently, the user lowers the operating part 253 of the reagent suction section 250a, moving it from the removal position Q1 toward the removal prevention position Q2 (see reference). Figure 18Subsequently, the reagent pipette 252 and the fixing pin 280 move downwards. First, the fixing pin 280 is inserted into the through hole 23d of the frame member 23, and then the reagent pipette 252 is inserted into the opening 21a of the plug member 21. In addition, since a pipette guide portion 21c is provided inside the reagent container bag 10 below the opening 21a, even if the entry angle of the reagent pipette 252 is slightly inclined relative to the central axis of the cylindrical portion 21d forming the opening 21a, the tip of the reagent pipette 252 is guided to the bottom of the reagent container bag 10 through the pipette guide portion 21c without contacting the inner surface of the reagent container bag 10. As described above, even if the wall sheet 11 near the opening 21a of the reagent container bag 10 is significantly recessed before the reagent container holding portion 251a is inserted, the shape of the reagent container bag 10 is corrected by contact with and being pressed by the pressing portion 350. The pressing force of the pressing part 350 increases the internal pressure of the reagent container 10, for example, causing the reagent 12 to flow from the rear end to the front end of the reagent container 10. As a result, the recessed wall sheet 11 is pushed outward of the reagent container 10, allowing the wall sheet 11 to retract from the position where the reagent pipette 252 passes, effectively preventing the reagent pipette 252 from contacting the wall sheet 11 and causing damage to the reagent container 10. Hereinafter, refer to Figures 25-29 The following describes a modified example of the pressing part 350. Hereinafter, the same reference numerals will be used for the constituent elements that are common to the above embodiments, and repeated descriptions will be omitted. Figure 25The pressing part 365 shown shares the same points as the pressing part 350 in the above embodiment at the first inclined surface 361a, the intermediate region 361c, and the second inclined surface 361b formed on the inner surface of the first sidewall 361 of the reagent container holding part 360, which faces the surface of the reagent container bag 10. However, the pressing part 365 differs from the pressing part 350 in that it has a pressing roller 363. The pressing roller 363 includes a rotation axis 364 along the vertical direction and is configured to rotate about the rotation axis 364. The pressing roller 363 protrudes from the inner surface of the sidewall 361, contacts the surface of the reagent container bag 10, and presses the reagent container bag 10 from the outside. The pressing roller 363 can rotate by contact when the reagent container bag 10 is inserted into the reagent container holding part 360, or it can be driven to rotate by a motor or the like. A plurality of pressing rollers 363 are provided in the reagent container holding part 360. An opening 362 is formed on the side wall 361, allowing the pressing roller 363 to protrude into the receiving space of the reagent container holding portion 360. The pressing roller 363 is positioned with a portion of the roller protruding from the opening 362 into the receiving space. Furthermore, the pressing roller 363 is positioned at three locations: the boundary between the first inclined surface 361a and the intermediate region 361c, the boundary between the intermediate region 361c and the second inclined surface 361b, and the boundary between the second inclined surface 361b and the deep side region 361e. The pressing roller 363 can be attached to and detached from the reagent container holding portion 360. According to the pressing portion 365, in addition to the first inclined surface 361a, the intermediate region 361c, and the second inclined surface 361b, the three pressing rollers 363 press the reagent receiving bag 10 from the outside to correct the shape of the bag. The size of the pressing roller 363 and the degree of its protrusion from the inner surface of the side wall 361 are not particularly limited. The pressing roller 363 can apply force in the direction of the storage space and can move in the horizontal direction. In addition, the number and arrangement of the pressing roller 363 are not particularly limited. For example, two or fewer or four or more pressing rollers 363 may be arranged side by side in the depth direction of the reagent container holding part 360. Figure 26 The press roller 366 shown is located at the point including the rotation axis 367 along the depth direction of the reagent container holding part, and... Figure 25 The press roller 363 shown is different. Furthermore, the press roller 366 is configured to move vertically. Within the reagent container holding section, the press roller 366 moves vertically while pressing the reagent receiving bag 10 to correct the bag's shape. The press roller 366 can rotate upon contact when the reagent receiving bag 10 is inserted into the reagent container holding section 360, or it can be driven to rotate by a motor or the like. Furthermore, the press roller 366 can also be configured to move vertically in conjunction with the reagent pipette 252 via a moving mechanism 254, and descend before the reagent pipette 252. The press roller 366 can be attached to and detached from the reagent container holding section 360 or the reagent suction section. Figure 27 (A) to Figure 27The pressing member 375 shown in (C) functions as a pressing part in the reagent container holding part 370 to press the reagent receiving bag 10 from the outside, and is movable in the vertical direction, which is consistent with... Figure 26 The pressing roller 366 shown is common. The pressing member 375 has a support shaft 376 extending in the vertical direction and entering the receiving space of the reagent container holding part 370, and a protrusion 377 formed at the front end of the support shaft 376. The protrusion 377 protrudes toward the reagent receiving bag 10 housed in the reagent container holding part 370 and presses the surface of the bag from the outside. The pressing member 375 can be attached and detached relative to the reagent container holding part 370 or the reagent suction part. The pressing member 375 is configured, for example, to move in the vertical direction in conjunction with the reagent pipette 252 via a moving mechanism 254, and to descend before the reagent pipette 252. Figure 27 (A) to Figure 27 As shown in (C), the pressing member 375 abuts against the upper part of the reagent container bag 10 and presses the reagent container bag 10 while moving from top to bottom. As a result, the internal pressure of the reagent container bag 10 increases, the reagent 12 as the contents flows, and the recessed portion of the wall sheet 11 is pushed out, thereby correcting the shape of the reagent container bag 10. Figure 28 (A) to Figure 28 The pressing member 385 shown in (C) is positioned in the reagent container holding part 380 opposite the reagent receiving bag 10 in the X direction, pressing the reagent receiving bag 10 from both sides in the X direction. The pressing member 385 is, for example, a pair of movable walls that are part of the receiving space of the reagent container holding part 380 and move in the X direction. The pressing member 385 can be configured to move in the X direction and apply force in the direction of the receiving space, by means of a motor, etc. Furthermore, the pressing member 385 can be attached to and detached from the reagent container holding part 380 or the reagent aspiration part. Figure 28 (B) and Figure 28 As shown in (C), a pair of pressing members 385 move inward toward the reagent container holding portion 380, pressing the reagent receiving bag 10 from both sides in the X direction. This causes the internal pressure of the reagent receiving bag 10 to rise, the reagent 12 to flow, and the recessed portion of the wall sheet 11 to be pushed out, thereby correcting the shape of the reagent receiving bag 10. Furthermore, in Figure 28 (A) to Figure 28 In the example shown in (C), a pair of movable walls located on both sides of the reagent container holding section 380 in the X direction move toward the reagent receiving bag 10. However, it is also possible to provide a movable wall only on one side of the reagent container holding section in the X direction, and press the reagent receiving bag 10 from that side. In this case, the internal pressure of the reagent receiving bag 10 can also be increased, and the shape of the reagent receiving bag 10 can be corrected.
[0055] like Figure 29As shown, the reagent container 100 can also be inserted into the reagent container holding part 390 while being held by the pressing attachment 394. The pressing attachment 394 has a pressing part 395 that presses the reagent receiving bag 10 from the outside, and is inserted into the reagent container holding part 390 together with the reagent container 100. It can be said that the reagent container holding part 390 has the pressing attachment 394 as a detachable pressing part. The pressing attachment 394 is a holding member of the reagent container 100, having a plate-shaped bottom part 398 extending in the depth direction of the reagent container holding part 390, and side walls 396, 397 erected at both ends in the width direction of the bottom part 398. The pressing attachment 394 has a pressing part 395 including a first inclined surface 396a, a middle region 396c, and a second inclined surface 396b. The pressing part 395 is formed in the side wall 396. The shapes of the first inclined surface 396a, the intermediate region 396c, and the second inclined surface 396b, and their arrangement on the side wall 396, respectively correspond to the shapes and arrangements of the first inclined surface 351a, the intermediate region 351c, and the second inclined surface 351b of the pressing part 350 constituting the reagent container holding part 251. Furthermore, the pressing attachment 394 can suspend the reagent container 100 in the same way as the protective member of the reagent kit described later; the protective member can also serve as the pressing attachment 394. In addition, the pressing attachment can be connected to the reagent container holding part and can be pulled out from the reagent container holding part. Hereinafter, refer to... Figures 30-36 The structure of the reagent kit 450, which is an example of an embodiment, is described in detail, especially the structure of the protective member 460 that protects the reagent container 100. Figure 30 This is a perspective view of the reagent kit 450 viewed from the front. Furthermore, the direction in which the front end of the reagent container 100 (the front end 23a of the frame member 23) faces is defined as the front of the reagent kit 450, and the direction in which the rear end of the reagent container 100 (the rear end 23b of the frame member 23) faces is defined as the rear of the reagent kit 450. (See diagram below.) Figure 30As shown, the reagent kit 450 includes a reagent container 100 and a protective member 460 for protecting the reagent container 100. The reagent kit 450 also includes a storage box 451 for housing the reagent container 100 and the protective member 460. The reagent container 100 is stored in the storage box 451 while protected by the protective member 460. As described above, the reagent container 100 includes a reagent holding bag 10 as a flexible packaging material container, a plug member 21 attached to the reagent holding bag 10, and a frame member 23 installed in the reagent holding bag 10 via the plug member 21. The plug member 21 forms an opening 21a for removing the reagent 12 contained in the reagent holding bag 10. Furthermore, to prevent the reagent 12 from leaking out of the opening 21a, the opening 21a is sealed by a sealing plug 21b. The reagent container 100 is protected by the protective member 460 and is transported and stored in the storage box 451. Details will be described later. The protective member 460 has a container suspension structure that suspends the reagent container bag 10 in a state where the bottom of the reagent container bag 10 is not supported from below and the opening is sealed by the sealing bolt 21b. The container suspension structure includes, for example, a receiving portion having an internal space capable of accommodating the reagent container bag 10. The upper end of the receiving portion is a support portion of the support frame member 23, and the length T1 from the upper end to the lower end of the receiving portion is longer than the vertical length H1 of the reagent container bag 10. Since the reagent container bag 10 is a flexible packaging material container that is easily deformed, it may deform significantly due to its own weight if transported or stored, for example, with the bottom of the reagent container bag 10 in contact with the bottom inner surface of the storage box 451. Therefore, the protective member 460 prevents the bottom of the reagent container bag 10 from contacting the bottom inner surface of the storage box 451, thus suppressing the deformation of the reagent container bag 10. During the transport of the reagent container 100, it is expected that a large force will be applied to the reagent container bag 10 due to impact or vibration, causing the reagent container bag 10 to deform significantly. Even if the reagent container bag 10 is significantly deformed, the shape of the reagent container bag 10 can be corrected by the pressing part of the sample analysis device 300. However, if the reagent container bag 10 is significantly deformed before being inserted into the reagent container holding part 251, it is sometimes difficult to insert the reagent container bag 10 smoothly. Therefore, it is desirable to suppress the deformation of the bag before the reagent container 100 is used. Furthermore, if the deformation of the reagent container bag 10 can be suppressed by the function of the protective member 460, then even when the reagent container 100 is positioned in a reagent container holding part without a pressing part, damage to the reagent container bag 10 caused by puncture by the reagent pipette can be effectively suppressed. The protective member 460 is a member that protects the reagent container 100 during transport of the reagent kit 450, mitigates impacts or vibrations that may act on the reagent container 100, and suppresses the deformation of the reagent container bag 10. As described above, the protective member 460 has a suspension structure for the reagent container 100, and holds the reagent container 100 in a state where the bottom of the reagent container bag 10 does not contact the bottom inner surface of the storage box 451 and floats from the bottom inner surface.Since the reagent container 10 is a flexible packaging material container, if its bottom is placed on the inner bottom surface of the storage box 451, it will deform significantly due to its own weight. However, by suspending the reagent container 10, the deformation of the bag can be suppressed, thus protecting the reagent container 100. Details will be described later. In this embodiment, the reagent container 100 is suspended using the frame member 23. Furthermore, the protective member 460 can stand upright while protecting the reagent container 100. The protective member 460 has an internal space for housing the reagent container 10, and the walls forming the internal space are made of a material with higher rigidity than the reagent container 10. The protective member 460 can be made of the same flexible material as the reagent container 10, but for example, it can be made of a material that is thicker and more rigid than the sheet constituting the reagent container 10. The protective member 460 is formed as a cylinder surrounding the reagent container 10, with openings at both axial ends of the cylinder, allowing the reagent container 10 to be inserted into the internal space of the cylinder. The reagent container 100 is held in place by the protective member 460 with the reagent holding bag 10 inserted into the internal space and the frame member 23 placed on the cylindrical wall. The protective member 460 may be made of resin, but from the viewpoint of manufacturing cost and reducing environmental impact, it is preferable to be made of paper material. Here, paper material refers to material mainly composed of plant fibers, not synthetic paper mainly composed of resin. In addition, the paper material may contain 5% or less of resin component as an additive. The protective member 460 is made of, for example, thick paper or corrugated cardboard, and more preferably, formed from a single sheet of thick paper into a cylindrical shape. The thickness of the thick paper is preferably 0.5 mm or more and 1.5 mm or less, or 0.7 mm or more and 1.2 mm or less. If the thickness of the thick paper is 0.5 mm or more, the protective member 460 can suspend the reagent holding bag 10 and can stand upright while holding the reagent container 100. The protective member 460, as the wall forming the internal space, has a pair of side portions 461 and a rear portion 462 formed in such a way as to connect the side portions 461 to each other. The protective member 460 is formed, for example, from a single sheet of thick paper into a cylindrical shape, having a corner tube shape corresponding to the shape of the reagent container bag 10. As described above, the reagent container bag 10 has a shape that expands significantly on the side of the insert sheet 13 and decreases in thickness towards the plug member 21. The protective member 460, in accordance with the shape of the reagent container bag 10, has a planar triangular shape. Details will be described later; the protective member 460 is formed as an isosceles triangle with a sharp front end. The reagent container bag 10 is inserted into the internal space of the protective member 460 with the wall sheet 11 facing the side portion 461 and the insert sheet 13 facing the rear portion 462. The side portion 461 supports the frame member 23 while the reagent container bag 10 is inserted into the internal space of the protective member 460, and the frame member 23 supports the reagent container bag 10.The side portion 461 has a height (vertical length) at which the bottom of the reagent container 10 does not protrude from the lower end of the side portion 461 when the frame member 23 is placed on the upper end of the side portion 461. Thus, the reagent container 10 is suspended without its bottom contacting the inner bottom surface of the storage box 451. A pair of side portions 461 have the same height, and the lower surface 23g of the frame member 23 rests on the upper end of the pair of side portions 461. A recess 465 is formed at the rear end of the protective member 460. The height of the upper end of the rear portion 462 and the portion of the side portion 461 adjacent to the rear portion 462 is reduced by one level due to the recess 465. Thus, the grip portion 25 of the frame member 23 is significantly exposed from the protective member 460, allowing for easy grasping of the grip portion 25 when removing the reagent container 100 from the protective member 460. The portions of the rear facet 462 and the side facets 461 adjacent to the rear facet 462 are preferably formed at a height that exposes approximately the entire grip portion 25 when the frame member 23 is mounted on the pair of side facets 461. In other words, the recess 465 is formed by cutting off the portions of the rear facet 462 and the side facets 461 adjacent to the rear facet 462 to expose approximately the entire grip portion 25. The protective member 460 has a bent portion 461a at the boundary of the pair of side facets 461, and has a shape that gradually tapers from the rear facet 462 side toward the bent portion 461a. The bent portion 461a becomes the front end of the protective member 460, forming one corner of the aforementioned triangle. The pair of side facets 461 and the bent portion 461a are formed, for example, by bending a sheet of thick paper. The spacing between the pair of side facets 461 gradually widens from the bent portion 461a toward the rear facet 462, and becomes largest at the rear end of the side facet 461, which is the boundary with the rear facet 462. The pair of side portions 461 are of the same size and have substantially identical shapes when overlapped. The protective member 460 also has a first opening 463 that extends significantly rearward from the bend 461a at the front end. The first opening 463 is formed across the pair of side portions 461 by significantly cutting away the front end and surrounding area of the protective member 460. The first opening 463 reduces the rigidity of the side portions 461, giving them spring-like elasticity. For example, when subjected to vertical external forces due to impacts or vibrations during transport, the side portions 461 flex and elastically deform, becoming capable of absorbing impacts or vibrations. As a result, the force transmitted from the side portions 461 to the reagent container 100 is mitigated, and damage to the reagent container 100 can be more effectively suppressed. The protective member 460 also has a bend, configured such that the protective member 460 deforms at the bend when a vertical external force is applied. In this embodiment, two thin, linear bends 461b and 461c are formed on each of the pair of side portions 461. The bent portions 461b and 461c extend from the rear of the side portion 461 toward the edge of the first opening 463, and together with the first opening 463, give the side portion 461 elasticity.Details will be described later. A pair of side portions 461 bend at the bends 461b and 461c, deforming the protective member 460, thereby absorbing impact or vibration. The storage box 451 is sized to accommodate the reagent container 100 protected by the protective member 460. The storage box 451 accommodates the reagent container 100 and the protective member 460 as a whole, keeping them from being exposed to the outside. Therefore, the storage box 451, like the protective member 460, protects the reagent container 100 during transport of the reagent kit 450. However, the storage box 451 does not have the function of suspending the reagent containing bag 10 to prevent bag deformation, as the protective member 460 does. The storage box 451 is, for example, a cardboard box with a rectangular shape, and is made of paper material, just like the protective member 460. The storage box 451 preferably has an internal space 451b that is just large enough to accommodate one reagent container 100. If the internal space 451b of the storage box 451 is too large, it is anticipated that the reagent container 100 may move and detach from the protective member 460 due to impact or vibration during transportation. Therefore, the internal space 451b is preferably small within a range that does not hinder the storage of the reagent container 100 in a protected state by the protective member 460. The storage box 451 has a lid 451a, configured such that the reagent container 100 can be moved in and out of the internal space 451b by opening the lid 451a. Hereinafter, refer to... Figures 31-34 The structure of the protective component 460 will be further described in detail. Figure 31 This is a three-dimensional view of reagent kit 450 viewed from the rear. Figure 32 This is a 3D view of the protective component from the front at 460 degrees. Figure 33 This is a 3D view of the protective component at 460 degrees from the rear. (For example...) Figures 31-33As shown, the protective member 460 includes a pair of side portions 461 and a rear portion 462 connecting the rear ends of the side portions 461 to each other, forming a cylindrical shape that is approximately triangular in plan view. The pair of side portions 461 have the same size. Since the width of the rear portion 462 along the B direction (length in the B direction) is less than the front-rear length of the side portion 461 along the A direction (length in the A direction), the triangle is an isosceles triangle with equal sides formed by the side portions 461. The width of the rear portion 462 is, for example, more than 30% and less than 50% of the front-rear length of the side portion 461, more preferably more than 35% and less than 45%. The protective member 460 is made of a sheet of thick paper and has a joint 466 for maintaining the cylindrical shape. The joint 466 is formed by forming a sheet of thick paper into a cylindrical shape, overlapping the ends of the thick paper to each other, and bonding them together with an adhesive. The length (overlap width of the thick paper) of the joint 466 along the circumference of the cylinder wall is, for example, 10 mm or more and 40 mm or less, or 15 mm or more and 35 mm or less. Furthermore, the joint 466 is formed along the entire axial length of the cylinder wall to which the joint 466 is formed. The joint 466 is formed on the rear side of the protective member 460 away from the first opening 463. The location of the joint 466 is not particularly limited; a preferred example is the portion of the side portion 461 adjacent to the rear portion 462. Since the joint 466 is formed by overlapping two sheets of thick paper, it has higher rigidity than other portions and is less prone to deformation. Therefore, compared to the front portion of the protective member 460, which is intended to be elastic by forming the first opening 463 and the bends 461b and 461c, it is preferable to form the joint 466 on the rear portion of the side portion 461. Alternatively, the joint 466 can also be formed using tape, a stapler, or the like. The upper position of the side portion 461 is not fixed as described above. By exposing the recess 465 of the handle portion 25, it is reduced by one level within a predetermined length from the rear end of the side portion 461. This predetermined length is, for example, set to be slightly longer than the longitudinal length of the handle portion 25. In the side portion 461, the frame member 23 is mounted on the portion further forward than the recess 465; therefore, the upper positions of this portion are preferably aligned. Furthermore, the lower positions of the side portions 461 are also preferably aligned; in this embodiment, the lower positions of the pair of side portions 461 are aligned along their entire length. Moreover, the height of the pair of side portions 461 is fixed from the front end of the side portion 461 to the portion forming the recess 465. In this case, the reagent container 100 can be supported more stably, and the self-standing stability of the protective member 460 is also improved. The lower position of the rear portion 462 can be above or aligned with the lower position of the side portion 461. As described above, a first opening 463 and bends 461b and 461c are formed on the protective member 460. The first opening 463 is a large opening formed across a pair of side portions 461 at the front end of the protective member 460, which exposes the reagent container bag 10 extensively.Furthermore, one bend 461b and one bend 461c are each formed on a pair of side portions 461, for a total of four bends. The first opening 463 and the bends 461b and 461c are formed in a manner that overlaps in the width direction (direction B) of the pair of side portions 461. That is, if the pair of side portions 461 overlap, the edges of the first openings 463 formed therein are consistent, and the bends are also consistent. Hereinafter, appropriate reference will be made. Figure 34 . Figure 34 This is a side view of the protective component 460. (For example...) Figure 34 As shown, the first opening 463 is roughly U-shaped in the side view of the protective member 460. The first opening 463 gradually widens towards the front of the protective member 460 and becomes longer in the vertical direction. At the intersection of the bend 461a and the edge of the first opening 463, there is a first front edge 463a on the upper side of the side portion 461 and a second front edge 463b on the lower side of the side portion 461. The distance D1 between the upper end of the side portion 461 and the first front edge 463a is the same as the distance D2 between the lower end of the side portion 461 and the second front edge 463b, or the distance D1 is shorter than the distance D2. Furthermore, at the edge of the first opening 463, the rear edge 463c closest to the rear portion 462 is located on the lower end side of the vertical center of the side portion 461. The edge of the first opening 463 is formed in an arc shape. The arc α connecting the first front edge 463a and the rear edge 463c has a different curvature than the arc β connecting the second front edge 463b and the rear edge 463c. Arc α has a greater degree of curvature and a larger average curvature than arc β. By making arc α significantly more curved than arc β, it is possible to more effectively absorb external forces acting in the vertical direction due to impacts or vibrations during the transport of the reagent kit 450. The vertical length D3 of the first opening 463 is the largest at the front end of the protective member 460. The maximum value of the vertical length D3 of the first opening 463 is, for example, more than 40% and less than 70% of the vertical length D of the side portion 461, more preferably more than 45% and less than 65%, or more than 50% and less than 60%, or may be greater than 50%. Furthermore, the maximum value of the front-rear length F1 of the first opening 463 is, for example, more than 25% and less than 50% of the front-rear length F of the side portion 461, more preferably more than 30% and less than 45%. If the size of the first opening 463 is within the specified range, it can stably support the reagent container 100 and more effectively absorb any impacts or vibrations that may act on the reagent container 100. Figures 31-33As shown, the bend 461b is slightly curved, protruding inward toward the protective member 460. The bend 461b is a long, straight bend extending in the front-rear direction of the side portion 461, formed by adding crease lines to the side portion 461. The bend 461b is the portion that appears folded when viewed from the outside of the side portion 461. When an external force is applied in the vertical direction, the side portion 461 bends inward at the bend 461b, thereby absorbing the external force. The side portion 461 can absorb external forces acting in the vertical direction by varying the degree of curvature of the bend 461b. The bend 461c is slightly curved, protruding outward toward the protective member 460. The bend 461c is a straight bend extending in a direction intersecting the front-rear and vertical directions of the side portion 461, formed by adding crease lines to the side portion 461. The bend 461c is the portion that is bent when viewed from the outside of the side portion 461. When an external force is applied in the vertical direction, the side portion 461 bends outward at the bend 461c, thereby absorbing the external force. The side portion 461 can absorb external forces acting in the vertical direction by varying the degree of bending of the bend 461c. The bend 461b slopes from the rear of the side portion 461 toward the edge of the first opening 463, such that it is located further down as it approaches the first opening 463. The bend 461b extends straight from the portion of the side portion 461 where the recess 465 is formed, past the arc α forming the edge of the first opening 463. Similarly, the bend 461c slopes from the rear of the side portion 461 toward the edge of the first opening 463, such that it is located further down as it approaches the first opening 463. The bent portion 461c extends straight from the portion of the side portion 461 where the recess 465 is formed and at a position lower than the bent portion 461b, passing over the rear end edge 463c of the first opening 463 or the portion close to the rear end edge 463c of the arc β. For example... Figure 34As shown, the inclination angle θb of the bent portion 461b relative to the protective member 460 in the front-rear direction is smaller than the inclination angle θc of the bent portion 461c. The angle θb is, for example, 10° or more and 30° or less, more preferably 15° or more and 25° or less. The intersection point of the bent portion 461b and the arc α is, for example, located at the center of the arc α in the length direction, within ±20% of the front-rear length F1 (length of the arc α) of the first opening 463 from the center position in the length direction of the arc α. Furthermore, the angle θc is, for example, 30° or more and 70° or less, more preferably 40° or more and 60° or less. The bent portion 461b extends from the middle position of the recess 465 in the vertical direction to the arc α of the first opening 463. Furthermore, the bent portion 461c extends from the lower end of the recess 465 to the rear end edge 463c of the first opening 463, or the arc β. The front-to-back length F2 of the bend 461b is, for example, more than 40% and less than 65% of the front-to-back length F of the side portion 461, or more than 50%. The front-to-back length F3 of the bend 461c is, for example, smaller than the front-to-back length F2 of the bend 461b, and is more than 30% and less than 55% of the front-to-back length F of the side portion 461, or less than 50%. As described above, the bends 461b and 461c are inclined relative to the front-to-back direction from the rear of the protective member 460 toward the front in a manner that gradually increases in size relative to each other, and are connected to the edge of the first opening 463. By forming such bends 461b and 461c together with the first opening 463, a spring-like elasticity can be imparted to the pair of side portions 461 supporting the reagent container 100, and external forces acting in the vertical direction due to impacts or vibrations during the transport of the reagent kit 450 can be absorbed more effectively. Figures 31-33As shown, the protective member 460 also has a second opening 464. The second opening 464 opens to the rear of the protective member 460 and is formed by cutting away the rear portion 462. By forming the second opening 464, the rigidity of the rear portion of the protective member 460 can be moderately reduced, and the rear portion is also given spring-like elasticity. The second opening 464 is formed, for example, slightly below the rear portion 462, with a vertical length of more than 30% and less than 60% or less than 50% of the vertical length of the rear portion 462. The second opening 464 has a generally quadrilateral shape when viewed from the rear of the rear portion 462 and is formed throughout the full width of the rear portion 462. Furthermore, the vertically extending edge of the second opening 464 is formed on the portion of a pair of side portions 461 adjacent to the rear portion 462. That is, the second opening 464 is formed beyond the range of the rear portion 462. The vertically extending edge of the second opening 464 curves gently in a manner that protrudes forward toward the protective member 460. Therefore, the rear end of the protective member 460 is easily bent when subjected to external forces in the vertical direction, thus easily absorbing the external forces. A bend 462a extending in the vertical direction is formed on the rear part 462. The bend 462a extends straight in the vertical direction from the center of the width direction of the rear part 462. Furthermore, the bend 462a is formed from the upper end of the rear part 462 to the upper edge of the second opening 464, and from the lower edge of the second opening 464 to the lower end of the rear part 462. The bend 462a enables the rear part 462 to be folded. If the rear part 462 can be folded, the volume of the protective member 460 is greatly reduced, thus making it effective in the transportation and storage of the protective member 460. Figure 35 This is a diagram showing the reagent kit 450 viewed from the front, illustrating the static state (A) and the state under the influence of an external force in the vertical direction (B). For example... Figure 35As shown in (A), the protective member 460 has a first shape, which suspends the reagent container 100 at a first height position T1 that is higher than the vertical length (height position) H1 of the reagent container 10. As described above, the protective member 460 has a container suspension structure. The container suspension structure includes a receiving portion (a pair of side portions 461 and a rear portion 462) that can accommodate the internal space of the reagent container 10. The upper end of the receiving portion is a support portion (the upper end of the pair of side portions 461) for supporting the frame member 23. The length T1 from the upper end to the lower end of the receiving portion is longer than the vertical length H1 of the reagent container 10. As described above, the frame member 23 of the reagent container 100 is placed on the upper end of the pair of side portions 461, and the bottom of the reagent container 10 is suspended in a floating state without protruding from the lower end of the side portions 461. Here, the first height position T1 means the height of the portion of the side portion 461 that holds the frame member 23 (the same applies to the second height T2 described later). When the protective member 460 has the first shape, i.e., when the side portion 461 is at height position T1, the first opening 463 has a generally elliptical shape with a longer vertical direction when viewed from the front. Furthermore, the second height (length) T2 can be longer or shorter than the vertical length H1 of the reagent container 10. However, from the viewpoint of effectively suppressing deformation or damage to the reagent container 10, the second length T2 is preferably longer than the length H1. Figure 35 As shown in (B), the protective member 460 can deform into Figure 35 The first shape shown in (A) and the second shape in which the reagent container 100 is suspended at a second height position T2, different from the first height position T1. The second shape of the protective member 460 is, for example, a shape in which the pair of side portions 461 supporting the reagent container 100 flex and become lower in height when an external force in the vertical direction is applied due to impact or vibration during the transport of the reagent kit 450. Furthermore, the protective member 460 can elastically deform like a spring, repeatedly deforming from the first shape to the second shape and then returning to the first shape when an external force in the vertical direction is applied, thereby absorbing the external force. In the second shape, compared with the first shape, the pair of side portions 461 bend significantly at the bends 461b and 461c, and the first opening 463 expands in the direction B. Thus, through the elastic deformation of the protective member 460, the impact or vibration during the transport of the reagent kit 450 can be absorbed. The protective member 460 deforms into the first shape and the second shape by the change in the degree of bending at the bends 461b and 461c. Furthermore, even when the protective member 460 deforms into its second shape, the reagent container 10 is maintained in a suspended state, floating above the bottom inner surface of the storage box 451. That is, according to the protective member 460, impacts or vibrations transmitted to the reagent container 10 are mitigated, and the suspended state of the reagent container 10 is consistently ensured. As a result, deformation or damage to the reagent container 10 is effectively suppressed. Figure 36This is a diagram showing a small-capacity reagent kit 470 as an example of an implementation, viewed from the front.
[0056] like Figure 36 As shown, reagent kit 470, like reagent kit 450, includes a reagent container 200 and a protective member 480 for protecting the reagent container 200. Reagent kit 470 may also include a storage box for storing the reagent container 200 and the protective member 480. The protective member 480 has a container suspension structure that suspends the reagent container 110 when its bottom is floating, keeping the bottom of the reagent container 110 from contacting the bottom inner surface of the storage box and suppressing deformation of the reagent container 110. Furthermore, the protective member 480 can stand upright while protecting the reagent container 200. The protective member 480 has the same shape as the protective member 460 of reagent kit 450, but since the reagent container 110 is smaller than the reagent container 10 of reagent kit 100, the overall size of the protective member 480 is smaller than that of the protective member 460. In particular, because the reagent container 110 is thin, the maximum width (length in the B direction) of the protective member 480 is equal to or smaller than the width of the frame member 23. Like the protective member 460, the protective member 480 has a pair of side portions 481 and a rear portion formed to connect the side portions 481 to each other. The protective member 480 is formed, for example, from a sheet of thick paper into a cylindrical shape, having a triangular shape in plan view. Furthermore, the protective member 480 has a first opening 483 that forms significantly rearward from a bend 481a at the front end. The first opening 483 spans the pair of side portions 481, moderately reducing the rigidity of the side portions 481 and giving them spring-like elasticity. Bends 481b and 481c are also formed on the pair of side portions 481, which are inclined relative to the front-rear direction from the rear of the protective member 480 towards the front in a manner that gradually widens at intervals and connect to the edge of the first opening 483. Hereinafter, refer to... Figures 37-41 A modified example of the protective member 460 will be described. Hereinafter, the same reference numerals will be used for the constituent elements that are common to the above embodiments, and repeated descriptions will be omitted. Figure 37 The protective member 510 shown shares similarities with the protective member 460 of the above embodiment in that it has a container suspension structure that suspends the reagent container 10 in a state where it floats above the bottom. Furthermore, like the protective member 460, the protective member 510 has a pair of side portions 511 and a rear portion 512 connecting the side portions 511 to each other. On the other hand, the protective member 460 is generally formed into a cylindrical shape, with the reagent container 10 inserted into the internal space of the cylinder through an opening at one axial end, while the protective member 510 has an upper portion 513 connecting the pair of side portions 511 and the rear portion 512, and does not have a cylindrical shape, which differs from the protective member 460. Figure 37As shown in (A), a groove-shaped opening 514 is formed on the upper surface 513 of the protective member 510, extending from the front end opposite to the rear surface 512 to near the rear surface 512. The upper surface 513 has a planar rectangular shape that is elongated in the front-back direction. The opening 514 extends straight along the long side of the upper surface 513 and narrows near the rear surface 512. The opening 514 includes a first region 514a formed from the front end of the upper surface 513 with a width that allows the upper end of the reagent container 10 to be inserted, and a second region 514b formed near the rear surface 512 with a width that allows the handle 25 of the frame member 23 to be inserted. The width of the first region 514a is smaller than the width of the frame member 23, and when the upper end of the reagent container 10 is inserted into the first region 514a, the two ends of the frame member 23 in the width direction hang on the edges of the first region 514a of the upper surface 513. Figure 37 As shown in (B), the reagent container 100 suspends the reagent container 10 by inserting the upper end of the reagent holding bag 10 into the opening 514 from the front end side of the upper part 513 with the handle 25 of the frame member 23 as the front end. The bottom of the reagent holding bag 10 is suspended from the storage box 451 (see reference). Figure 30 The reagent container 10 is held in a floating state by the protective member 510. The pair of side portions 511 have a height such that, with the opening 514 inserted at the upper end of the reagent container 10 and the frame member 23 supported by the upper portion 513, the bottom of the reagent container 10 does not contact the bottom inner surface of the storage box 451. According to the reagent kit 500 equipped with the protective member 510, similar to the reagent kit 450, deformation of the reagent container 10 during transportation can be effectively suppressed. The protective member 510 can be made of rigid resin or paper material. Furthermore, bends for absorbing impacts or vibrations during transportation of the reagent kit 500 can be formed on the pair of side portions 511. The bends give the side portions 511 spring-like elasticity. The protective member 510 can be deformed, for example, by changing the degree of bending of the bends, into a first shape and a second shape with different heights for suspending the reagent container 100. Figure 38 The protective member 520 shown includes a pair of side portions 521, a rear portion 522, and a top portion 523, and has the same overall structure as the protective member 510. The protective member 520 has a bottom portion 525 opposite to the top portion 523, but may also lack the bottom portion 525. Figure 38 As shown in (A), a groove-shaped opening 524 is formed on the upper part 523, extending from the front end opposite to the rear part 522 to near the rear part 522. The width of the opening 524 is large enough to allow the upper end of the reagent container bag 10 to be inserted. The width of the opening 524 is smaller than the width of the frame member 23, and when the upper end of the reagent container bag 10 is inserted into the opening 524, both ends of the frame member 23 in the width direction hang on the edges of the opening 524 of the upper part 523. Figure 38 As shown in (B), the reagent container 100 inserts the upper end of the reagent holding bag 10 into the opening 524 from the front end side of the upper surface 523 by means of the bolt member 21 side of the frame member 23 as the front end, thereby suspending the reagent holding bag 10 and holding it in a state where it floats from the bottom inner surface of the storage box 451, etc., by the protective member 520. The pair of side portions 521 have a height such that when the upper end of the reagent holding bag 10 is inserted into the opening 524 and the frame member 23 is supported by the upper surface 523, the bottom of the reagent holding bag 10 does not contact the bottom inner surface of the storage box 451. According to the reagent kit 501 equipped with the protective member 520, deformation of the reagent holding bag 10 during transportation, etc., can be effectively suppressed. The difference between the protective member 520 and the protective member 510 is that the width of the opening 524 is fixed along its entire length, and the bolt member 21 side of the frame member 23 is arranged on the rear surface 522 side of the opening 524. In this case, when removing the reagent container 100 from the protective member 520, the gripping part 25 of the frame member 23 is positioned at the front end of the large opening of the protective member 520, making it easy to grasp the gripping part 25 and facilitating the operation of the reagent container 100. Furthermore, the protective member 520 can be made of rigid resin or paper material. Additionally, bent portions can be formed on the pair of side portions 521. Figure 39 This is a cross-sectional view showing a modified example of protective member 526, which is a protective member 520. For example... Figure 39 As shown, the protective member 526 differs from the protective member 520 in that it has an inner wall 527 on the inner side of the side portion 521, on which a pressing portion 528 is formed to press the reagent container bag 10 from the outside. Alternatively, the pressing portion 528 may also be formed on the side portion 521, or an accessory having the pressing portion 528 may be inserted into the protective member 520. The pressing portion 528 includes a first inclined surface 528a, a middle region 528c, and a second inclined surface 528b, and has the function of correcting the shape of the reagent container bag 10. The shapes and arrangements of the first inclined surface 528a, the middle region 528c, and the second inclined surface 528b correspond to the shapes and arrangements of the first inclined surface 351a, the middle region 351c, and the second inclined surface 351b of the pressing portion 350 constituting the reagent container holding portion 251, respectively. The protective member 526 has a container suspension structure for suspending the reagent container bag 10 in a state where the bottom of the reagent container bag 10 is floating, and a container pressing structure for pressing the reagent container bag 10 from the outside. According to the protective member 526, the reagent container bag 10 is suspended by the upper part 523 supporting the frame member 23, and the reagent container bag 10 is pressed from the outside by the pressing part 528. In this case, for example, it is possible to maintain the shape of the reagent container bag 10 after it has been corrected by the pressing part 528. Figure 40The protective member 530 shown has multiple support rods 531 for suspending and holding the reagent container 100. A suspension plate 532 with through holes 533 for inserting the support rods 531 is mounted on the frame member 23 of the reagent container 100. The protective member 530 has three support rods 531, and the suspension plate 532 has three through holes 533 for inserting the support rods 531 one by one. The suspension plate 532 is detachably mounted to the frame member 23, for example, with the portion having the through holes 533 erected on the frame member 23 and the through holes 533 opening in the B direction. According to the reagent kit 502 equipped with the protective member 530, deformation of the reagent container 10 during transportation, etc., can be effectively suppressed. Figure 41The protective member 540 shown has a container pressing structure that presses down on the reagent container 10 from the outside, but does not have a hanging structure for the reagent container 10. The protective member 540 has a pair of opposing side portions 541, a front portion 542, and a rear portion 543 opposite to the front portion 542, and is generally formed into a rectangular cylindrical shape. Additionally, the protective member 540 may have a bottom portion, forming a bottomed cylindrical shape. The pair of side portions 541 slope downwards towards each other, and the perimeter of the protective member 540 gradually decreases towards the lower end. Furthermore, the width (length in the B direction) of the front portion 542 is smaller than the width (length in the B direction) of the rear portion 543, and the protective member 540 tapers from the rear to the front. The pair of side portions 541 are configured to abut against the surface of the reagent container 10 and press down on the reagent container 10 from the outside. The pair of side portions 541 are configured such that the distance between them at their upper ends is greater than the maximum thickness of the reagent container 10, and the distance between them at their lower ends is smaller than the maximum thickness of the reagent container 10. Therefore, when the reagent container 10 is inserted into the protective member 540 from above, a pair of side portions 541 clamp the reagent container 10 from both sides in the thickness direction (both sides in the B direction). This increases the internal pressure of the reagent container 10, suppressing deformation of the reagent container 10. Therefore, according to the reagent kit 503 equipped with the protective member 540, deformation of the reagent container 10 during transportation, etc., can be effectively suppressed. Furthermore, the above embodiments and variations can be appropriately modified without compromising the purpose of the present invention. For example, in the above embodiments, the reagent container 100 is provided as a reagent kit protected by the protective member, and the protective member is removed before the reagent container 100 is placed in the sample analysis device 300, but it can also be placed in the sample analysis device 300 while protected by the protective member. In addition to the frame member 23 that fits into the guide groove 270 of the sample analysis device 300, the reagent container 100 may also have a second frame member for suspending the protected member. In this case, the reagent container 100 can be placed in the sample analysis device 300 while protected by the protective member. Furthermore, in the above embodiment, a sample analysis device 300 with a pressing part in the reagent container holding section that presses the reagent holding bag 10 from the outside is exemplified. However, the reagent kits in the above embodiment and its variations can also be provided to sample analysis devices without a pressing part. In this case, deformation of the reagent holding bag 10 during transportation is suppressed by the protective member, and the reagent container 100 is placed in the sample analysis device without significant deformation of the reagent holding bag 10. Furthermore, in the above embodiment, the sealing plug 21b of the opening 21a of the reagent container 100 is exemplified as a sealing film that can be pierced by the reagent pipette 252. However, the sealing plug can also be a cap that cannot be pierced by the reagent pipette 252. In this case, it is preferable that the user removes the sealing plug before placing the reagent container 100 in the sample analysis device 300.
[0057] Furthermore, while a blood cell counting device was exemplified as a sample analysis device in the above embodiments, the sample analysis device is not limited to this. For example, the sample analysis device could also be a coagulation analysis device for performing blood coagulation analysis or an immunoassay device. However, the determination performed by a blood cell counting device is the most frequently performed blood test, and the number of samples is greater compared to coagulation analysis devices and immunoassay devices. Therefore, the consumption of reagents is also greater, and it is desirable to increase the capacity of the reagent container. If the capacity of the reagent container is increased, the usage period after opening becomes longer, thus suppressing reagent deterioration caused by air flowing into the reagent container becomes more important. Therefore, the sample analysis device is preferably a blood cell counting device, and the reagent 12 is preferably a reagent for determination performed by the blood cell counting device.
Claims
1. A reagent kit, characterized in that... have: A reagent container having: a flexible reagent holding bag for holding reagents drawn by a reagent pipette disposed in a sample analysis device, and having an opening disposed in the reagent holding bag and allowing the reagent pipette to enter the interior of the reagent holding bag; And a sealing plug to seal the opening; as well as Protective components protect the reagent container. The protective component has at least one of the following: A container suspension structure is configured to suspend the reagent container bag in a state where the bottom of the reagent container bag is not supported from below and the opening is sealed by the sealing plug. as well as The container pressing structure is configured to press the reagent container bag from the outside while the opening is sealed by the sealing plug.
2. The reagent kit according to claim 1, characterized in that, The protective component has the container suspension structure. The reagent container also includes a frame member disposed at the upper part of the reagent holding bag. The container suspension structure has a receiving section, which has an internal space capable of accommodating the reagent container bag. The upper end of the receiving portion is configured as a frame member to support the reagent container. The length from the top to the bottom of the receiving section is longer than the length of the reagent containing bag in the vertical direction.
3. The reagent kit according to claim 2, characterized in that, The walls forming the interior space of the containment section are made of a material with higher rigidity than the reagent containment bag.
4. The reagent kit according to claim 1, characterized in that, The protective component has the container suspension structure. The protective member can be deformed into a first shape for suspending the reagent container at a first height position, and a second shape for suspending the reagent container at a second height position different from the first height position.
5. The reagent kit according to claim 4, characterized in that, The protective member has a bending portion, which is configured to be flexible. The protective member deforms into the first shape and the second shape by changing the degree of bending of the bending portion.
6. The reagent kit according to claim 1, characterized in that, The protective component is self-supporting while protecting the reagent container.
7. The reagent kit according to claim 1, characterized in that, The protective component is made of paper material.
8. The reagent kit according to claim 1, characterized in that, The protective component is a component that protects the reagent container during the transport of the reagent kit.
9. The reagent kit according to claim 1, characterized in that, The reagent container also includes a frame member disposed at the upper part of the reagent holding bag. The protective component has the container suspension structure. The protective member is configured to suspend the reagent container bag by supporting the frame member.
10. The reagent kit according to claim 9, characterized in that, The shape of the frame member corresponds to the internal shape of a reagent container holding part configured to hold the reagent container, which is disposed in the sample analysis device.
11. The reagent kit according to claim 9, characterized in that, The frame member has a grip portion configured for the user of the sample analysis device to hold.
12. The reagent kit according to claim 1, further comprising: A storage box configured to house the protective member and the reagent container protected by the protective member.
13. The reagent kit according to claim 1, characterized in that, The sealing plug of the reagent container can be penetrated by the reagent pipette.
14. The reagent kit according to claim 1, characterized in that, The reagent container includes a first face, a second face opposite to the first face, and a corner portion folded between the first face and the second face.
15. The reagent kit according to claim 1, characterized in that, The reagent container bag holds a quantity of the reagent of more than 20 mL and less than 100 mL.
16. The reagent kit according to claim 1, characterized in that, The reagent container bag holds a quantity of the reagent of more than 100 mL and less than 500 mL.
17. The reagent kit according to claim 1, characterized in that, The reagent is the reagent used in blood testing as part of the blood cell counting device of the sample analysis apparatus.
Citation Information
Patent Citations
Analysis device and reagent container
WO2011105247A1