A laboratory hazardous article protection and management system and method

Abstract

The application discloses a laboratory dangerous article protection and management system and method, the system comprises an environment protection subsystem, which is used for providing physical isolation and clean operation environment and monitoring the environment safety state in real time; a process supervision subsystem, which is used for video monitoring, whole-process visual recording and behavior analysis of experimental operation process; a personnel training subsystem, which is used for standardized and immersive skill training and examination of operating personnel; a storage management subsystem, which is used for storage and management of dangerous articles; a stock management server and an information tracing subsystem, which are used for structurally storing all data from each subsystem and providing a graphical query interface. The application constructs a dangerous article whole life cycle intelligent management system covering all factors of "article-person-environment-data", and realizes the transformation from passive protection to active early warning, from experience dependence to digital specification, and from local management to global tracing.

Description

Technical Field

[0001] This application belongs to the field of hazardous materials control technology, specifically relating to a laboratory hazardous materials protection and control system and method. Background Technology

[0002] In analytical laboratories of environmental monitoring centers, disease control centers, and research institutes, it is frequently necessary to prepare and use highly toxic chemical standards such as dioxins. These substances are extremely toxic (internationally recognized as Group 1 carcinogens) and have extremely low safety thresholds (routine working solutions are in the picogram / microliter range). The entire process of their management, preparation, and use poses extremely high risks of occupational exposure and environmental pollution. Currently, the management of such hazardous materials generally suffers from the following technical deficiencies: Outdated protective measures: Operations are usually carried out in ordinary fume hoods or open lab benches, which cannot completely prevent the escape of toxic vapors and the diffusion of aerosols, resulting in insufficient physical protection. Lack of process supervision: The entire preparation process (weighing, transferring, diluting, and volume adjustment) relies on the operator's self-awareness and experience, lacking objective and continuous technical supervision methods, making it impossible to detect and correct operational errors and violations in real time. Weak storage control: Storage equipment (such as dedicated refrigerators) usually only has basic temperature and humidity display functions, lacking continuous, traceable environmental data recording and intelligent alarms. The storage and retrieval process often does not strictly adhere to the national "two-person, two-lock" system for highly toxic chemicals, creating a safety loophole where only one person handles high-risk materials. Information traceability is difficult: Management records are mainly paper-based, leading to problems such as untimely recording, easy loss, and easy tampering. The entire lifecycle information chain, from procurement, warehousing, storage, requisition, preparation, use to waste liquid disposal, is broken, making it difficult to achieve rapid, accurate, and tamper-proof full traceability, and failing to meet the stringent requirements of regulations such as the new "Regulations on the Safety Management of Hazardous Chemicals." Training methods are primitive: Skills transfer is mostly based on a master-apprentice oral instruction model, lacking a unified, standardized, repeatable, and assessable standardized operating procedures (SOP) immersive training and assessment system, resulting in inconsistent training effectiveness and quality.

[0003] While existing technologies include independent negative pressure glove boxes, video surveillance systems, RFID warehouse management systems, or VR training systems, these are all fragmented and isolated solutions. These solutions have limited functionality, and data cannot be shared between different stages. They fail to form a closed-loop intelligent control system covering the entire process from "goods" to "personnel" to "environment," and thus cannot systematically address the safety and management challenges faced by hazardous materials laboratories. Summary of the Invention

[0004] To overcome the shortcomings of existing technologies, this application provides a laboratory hazardous materials protection and control system and method. It is designed for extremely small amounts of highly toxic substances such as dioxins, polycyclic aromatic hydrocarbons, and organic mercury. The system integrates intelligent environmental protection, operation process monitoring, personnel simulation training, storage safety control, and full-process information traceability, overcoming the shortcomings of existing technologies such as fragmented solutions, data silos, and broken control chains.

[0005] To achieve the above objectives, this application adopts the following technical solution:

[0006] A laboratory hazardous materials protection and control system includes:

[0007] The environmental protection subsystem includes a negative pressure operating chamber and a multi-parameter environmental monitoring network; the negative pressure operating chamber is used to provide a physically isolated and clean operating environment, and the multi-parameter environmental monitoring network is used to monitor the environmental safety status in real time.

[0008] The process monitoring subsystem is used for full-process visual recording and behavioral analysis of experimental operations via video surveillance. The subsystem includes a multi-angle high-definition video monitoring unit and a behavior recognition and analysis server. The multi-angle high-definition video monitoring unit includes a panoramic camera and a detail camera deployed in the negative pressure operating chamber. The panoramic camera monitors the operator's full-body posture and the overall environment inside the chamber, while the detail camera focuses on monitoring micro-movements during key operations. The behavior recognition and analysis server is connected to the multi-angle high-definition video monitoring unit and has a built-in behavior recognition model trained based on deep learning algorithms. This model analyzes the video stream to identify operational compliance, abnormal events, and safety compliance.

[0009] The personnel training subsystem is used to provide standardized and immersive skills training and assessment for operators. The personnel training subsystem includes a VR / AR immersive training platform, which includes VR head-mounted displays and / or AR glasses, a standardized operation training module for 3D simulation, an emergency response drill module, an error operation warning module, and a training management and assessment module.

[0010] The storage control subsystem is used for the storage and control of hazardous materials. The storage control subsystem includes storage devices and an RFID lifecycle tagging system. The storage devices include a dual-person, dual-lock electronic access control system, door status monitoring sensors, an uninterruptible power supply, and a built-in video recording unit. The RFID lifecycle tagging system affixes an RFID electronic tag to each hazardous material, and the RFID electronic tag stores the unique identification information of the corresponding hazardous material.

[0011] An inventory management server, connected to the storage device and the RFID reader / writer of the RFID lifecycle tag system, is used for automatic inventory counting and ledger updates based on RFID data; and

[0012] The information traceability subsystem includes a full-process database and a digital traceability audit engine; the full-process database is used to structure and store all data from each subsystem; the digital traceability audit engine is used to provide a graphical query interface.

[0013] As a preferred embodiment, the negative pressure operating chamber includes a sealed chamber composed of a stainless steel frame and a transparent protective panel. The front of the sealed chamber is provided with a glove operating port, and the side is provided with an interlocked transfer window. The sealed chamber establishes and maintains a working negative pressure.

[0014] The multi-parameter environmental monitoring network includes an ionization detector for monitoring the concentration of volatile organic compounds, a laser particle counter for monitoring the concentration of aerosol particles, a temperature and humidity sensor for monitoring the temperature and humidity inside the cabin, and a differential pressure sensor for real-time monitoring of the pressure difference between the inside and outside of the cabin.

[0015] The environmental protection subsystem also includes an emergency response controller, which is connected to the multi-parameter environmental monitoring network. The emergency response controller is pre-set with a graded response strategy, which includes: automatically increasing the exhaust volume and providing a voice prompt when the organic compound concentration monitoring value reaches the warning threshold; triggering an audible and visual alarm and recording the event when the organic compound concentration monitoring value reaches the alarm threshold; and automatically locking the pass-through window and automatically increasing the exhaust volume by more than double and sending an alarm message when the organic compound concentration monitoring value reaches the emergency threshold.

[0016] As a preferred embodiment, the graphical query interface is used to trace the complete life cycle of hazardous materials and automatically generate a report, which is associated with timestamped video or data records.

[0017] As a preferred embodiment, the dual-person dual-lock electronic access control system includes a dual-person authorization and access control logic unit; the dual-person authorization and access control logic unit generates an unlocking command based on the fact that two operators swipe their personal identification cards and enter independent passwords on the access control terminal in sequence, and that the operation interval is less than a preset time after verifying that the permissions of both are valid.

[0018] As a preferred embodiment, all static sealing joints in the sealed chamber are equipped with sealing strips; the rotating shaft dynamic sealing parts of the glove operating port and the transfer window adopt a double sealing structure combining lip seal and magnetic seal; the negative pressure operating chamber also includes an electronic balance, the balance body of which is embedded in a stainless steel operating table and connected to the sealed chamber through an active air-float vibration isolation table or a passive marble base.

[0019] As a preferred embodiment, the top air supply unit of the sealed chamber is equipped with a HEPA high-efficiency particulate filter, and the bottom exhaust unit is connected in sequence to the exhaust grille and the activated carbon adsorption tank; the sealed chamber is also equipped with a variable frequency fan, and the exhaust volume is dynamically adjusted by a closed-loop PID control system composed of the variable frequency fan and the differential pressure sensor.

[0020] As a preferred embodiment, the system also includes a management platform and a system data bus, and a central control engine. The management platform is coupled to the environmental protection subsystem, the process monitoring subsystem, the personnel training subsystem, the storage control subsystem, the inventory management server, and the information traceability subsystem through the system data bus and the central control engine, respectively.

[0021] As a preferred embodiment, the operational standardization includes the pipette holding angle, the bottle cap opening sequence, and the mixing technique; the abnormal events include liquid spillage and container tipping; and the safety compliance includes whether the prescribed protective equipment is worn and whether there is fatigue during operation.

[0022] As a preferred embodiment, the unique identification information includes: substance name, batch number, concentration, expiration date, storage location, preparation record, remaining amount, and disposal status.

[0023] In addition, this application also provides a method for the protection and control of hazardous materials in a laboratory using the laboratory hazardous materials protection and control system described above, comprising:

[0024] After the hazardous materials pass inspection, RFID electronic tags are affixed or bound to them, and the information of the hazardous materials is entered into the information traceability subsystem to complete the warehousing registration.

[0025] Safe storage involves storing hazardous materials with RFID tags in a safe storage device, and then continuously monitoring and recording the temperature and humidity of the storage environment. This storage and retrieval operation requires authorization from two people and is automatically recorded. The storage and retrieval information is updated to the full-process database in real time.

[0026] For requisition and preparation, the operator submits a requisition application, and the storage device is unlocked after authorization by two people. When the operator takes out hazardous materials, the RFID reader automatically identifies and records them, associating them with the operation task to be performed during this requisition.

[0027] Controlled operation: The operator enters the negative pressure operating chamber, and then the negative pressure operating chamber automatically starts environmental monitoring and video recording; during the operation, the behavior recognition and analysis server analyzes the standardization of the operation in real time and provides voice guidance or warnings, and all operation details are fully recorded.

[0028] After the operation is completed, update the preparation information and usage of hazardous materials, and write the remaining information into the tag using an RFID reader.

[0029] The waste liquid disposal closed loop involves placing the generated waste liquid into waste liquid bottles with RFID tags, and registering the nature, quantity, and disposal method of the waste liquid. After disposal, the tag status is updated to complete the information closed loop of the entire life cycle.

[0030] Full traceability and auditing: Operators can query the entire information chain of hazardous materials through a graphical query interface and export structured reports.

[0031] Compared with the prior art, this application has the following advantages:

[0032] This application presents a highly integrated, data-closed-loop intelligent protection and control system for laboratory hazardous materials. Through deep integration, it constructs an intelligent control system for the entire life cycle of hazardous materials, covering all elements of "materials-people-environment-data," achieving a fundamental transformation from passive protection to proactive early warning, from experience-based reliance to digital standardization, and from local management to global traceability.

[0033] This application achieves inherent safety by using a negative pressure operating chamber and real-time environmental monitoring to realize a closed-loop operation of hazardous materials from weighing to preparation, fundamentally curbing the release of toxic substances and greatly reducing the risk of occupational exposure and environmental pollution.

[0034] This application improves process controllability by combining video surveillance and behavior recognition to achieve objective, continuous, and intelligent supervision of high-risk operation processes, transforming operations from "invisible and uncontrollable" to "visible and correctable."

[0035] This application ensures storage quality and safety by using continuous environmental monitoring, dual-person dual-lock, access recording, and RFID for precise management, thus ensuring the quality stability of standard products during storage and preventing unauthorized access.

[0036] This application establishes a standardized training system and utilizes VR / AR technology to provide a unified, standardized, repeatable, and safe immersive training program, which significantly improves the efficiency and quality of personnel skills transfer.

[0037] This application constructs an immutable traceability chain, forming a data closed loop from source to end through automatic data collection and correlation throughout the entire process, meeting strict quality management requirements, and achieving true "traceable source, traceable destination, and accountable responsibility";

[0038] This application is configurable and scalable. Monitoring parameters, response thresholds, and management rules can all be flexibly configured through software. In the future, by adding sensor modules, connecting to external systems such as LIMS, and adjusting management parameters, it can be expanded at low cost to manage other high-risk chemicals in the laboratory and even biosafety and radioactive source management without modifying the hardware. This achieves "one system for multiple purposes", avoids redundant construction, improves resource utilization efficiency, and provides a unified and scalable intelligent platform solution for laboratory safety management.

[0039] This application possesses a high degree of safety and reliability, ensuring stable operation and data security, and meeting the stringent requirements for the reliability of the system itself in the management of high-risk chemicals. Attached Figure Description

[0040] The accompanying drawings, which are included to provide a further understanding of this application and form part of this application, illustrate exemplary embodiments of the application and, together with their description, serve to explain the application, but do not constitute an undue limitation of the application. In the drawings:

[0041] Figure 1 : Overall architecture diagram of the system in this application.

[0042] Figure 2 : A schematic diagram of the negative pressure operating chamber in this application.

[0043] Figure 3 This application presents a schematic diagram of the data flow and functions of the storage control subsystem.

[0044] Figure 4 This application includes a flowchart of the entire lifecycle management of hazardous materials. Detailed Implementation

[0045] To enable those skilled in the art to better understand the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings.

[0046] In the description of this application, it should be understood that the relationship between the method steps can be sequential or non-sequential, as long as it does not affect the overall technical effect, and therefore should not be construed as a limitation of this application. The following description of this application is merely a description of individual embodiments of the technical solution of this application; other embodiments are not shown in the following description, but this does not mean that this application excludes these other embodiments, nor is the technical solution of this application limited to the specific implementations described below, and the scope of protection of this application is not limited to the specific implementations described below. Based on the embodiments in this application, all other embodiments obtained by those skilled in the art without creative effort should fall within the scope of protection of this application.

[0047] It should be noted that if the terms "first," "second," etc., appear in the specification, claims, and accompanying drawings of this application, such descriptions are only used to distinguish similar objects and are not necessarily used to describe a specific order or sequence. It should be understood that such terms can be used interchangeably where appropriate so that the embodiments of this application described herein can be implemented in orders other than those illustrated or described herein. The term "intelligence" appearing in this specification does not limit specific means or methods, but only describes the overall performance and has no special limitation. Furthermore, the terms "comprising" and "having," and any variations thereof, are intended to cover non-exclusive inclusion; for example, a process, method, system, product, or device that includes a series of steps or units is not necessarily limited to those steps or units explicitly listed, but may include other steps or units not explicitly listed or inherent to these processes, methods, products, or devices.

[0048] like Figure 1 As shown, the laboratory hazardous materials protection and control system of this application includes the following five core subsystems that are interconnected:

[0049] The intelligent environmental protection subsystem provides a physically isolated and clean operating environment and monitors environmental safety status in real time. It consists of an intelligent negative pressure operating chamber and a multi-parameter environmental monitoring network. The intelligent negative pressure operating chamber comprises a sealed chamber with a stainless steel frame and transparent protective panels. A glove port is located on the front, and a pass-through window with interlocking functionality is located on the side. Structural sealing utilizes closed-cell foamed silicone or fluororubber sealing strips at all static sealing joints within the chamber. Its sealing performance aims to meet system control requirements: under rated exhaust volume, it can quickly establish and stably maintain a working negative pressure of -30Pa to -50Pa, with the leakage compensation airflow required to maintain this negative pressure not exceeding 5% of the total exhaust volume. The glove port and the key dynamic sealing components of the pass-through window's rotating shaft employ a dual sealing structure combining lip seals and magnetic seals to address the sealing challenges posed by dynamic operation, ensuring overall sealing performance meets the requirements for stably maintaining the working negative pressure. The chamber integrates a high-efficiency supply air filtration unit and an exhaust air high-efficiency filtration and activated carbon adsorption unit, creating a gradient negative pressure to ensure unidirectional airflow. Multi-parameter environmental monitoring network: Deployed within the operating cabin and key areas, including: a photoionization detector for monitoring volatile organic compound (VOC) concentration; a laser particle counter for monitoring aerosol particulate matter concentration; a temperature and humidity sensor for monitoring cabin temperature and humidity; and a differential pressure sensor for real-time monitoring of the pressure difference between the inside and outside of the cabin. Intelligent emergency response controller: Connected to the environmental monitoring network, with a pre-set tiered response strategy: When the VOC concentration reaches the warning threshold, automatically increase the exhaust volume and provide a voice prompt; when the alarm threshold is reached, trigger an audible and visual alarm and record the event; when the emergency threshold is reached, automatically lock the pass-through window and activate the emergency exhaust mode.

[0050] The intelligent process monitoring subsystem provides full-process visual recording and AI-powered intelligent behavior analysis of the operation process via video surveillance. Multi-angle high-definition video monitoring units include a panoramic camera deployed on the ceiling to monitor the operator's full-body posture and the overall environment inside the chamber; and detail cameras deployed above the worktable to focus on monitoring micro-movements during critical operations such as weighing and pipetting. Video data supports local storage and cloud backup, and features slow-motion playback. An AI behavior recognition and analysis server connects to the video monitoring units and incorporates a behavior recognition model trained using deep learning algorithms. This model can analyze the video stream in real time, identifying operational compliance (e.g., pipette holding angle, bottle cap opening sequence, mixing techniques); abnormal events (e.g., liquid spillage, container tipping); and safety compliance (e.g., whether required protective equipment is worn, and whether there is fatigue during operation). When non-compliant or abnormal behavior is detected, the system provides real-time corrective prompts to the operator via a voice module. As is well known, the behavior recognition model used by this AI behavior recognition and analysis server adopts conventional behavior recognition and analysis methods. The specific algorithm is not the main inventive concept of this application. This application mainly uses the model to identify various operations in order to capture non-standard or abnormal operation behaviors and provide correction prompts.

[0051] The intelligent personnel training subsystem is used for standardized, immersive skills training and assessment of operators. The VR / AR immersive training platform includes VR headsets and / or AR glasses. The platform incorporates a standardized 3D simulation operation training module (simulating the entire process of weighing, transferring, and preparing), an emergency response drill module (simulating handling procedures for scenarios such as leaks and fires), and an error operation warning module (displaying common operational errors and their potential consequences). The training management and assessment module records data such as trainees' operational trajectories, step compliance, and completion time in the VR / AR environment, generating quantitative evaluation reports to visualize and assess training effectiveness.

[0052] The intelligent storage and control subsystem is used for the safe storage and precise control of standard concentrates and working solutions of hazardous materials. Intelligent safe storage equipment consists of modified dedicated refrigerators or storage cabinets. In addition to high-precision temperature and humidity control, it integrates a dual-person, dual-lock electronic access control system (requiring simultaneous authentication by two authorized personnel to open), door status monitoring sensors (recording the time and duration of each door opening and closing), an uninterruptible power supply, and a built-in video recording unit that automatically records recordings during storage and retrieval operations. An RFID lifecycle tagging system is used to affix RFID electronic tags to each standard concentrate bottle, working solution bottle, and waste liquid bottle. The tag stores or associates unique identification information for the item, including: substance name, batch number, concentration, expiration date, storage location, preparation record (for working solutions), remaining quantity (dynamically updated), and disposal status.

[0053] The intelligent inventory management server connects with intelligent storage devices and RFID readers to achieve the following functions: automatic inventory counting and ledger updates based on RFID data; automatic prompts for usage order according to the "first-in, first-out" and "near-expiration priority" principles; automatic generation of purchase requests when inventory is below the safety threshold; and early warning for expired or near-expiration items.

[0054] The intelligent information traceability subsystem serves as the system's data hub, integrating, managing, and tracing data across the entire process. The end-to-end database provides structured storage for all data from various subsystems, including: procurement and acceptance data, warehousing data, historical storage environment data, access records (personnel, time, items, videos), operation process videos and AI analysis reports, preparation and usage records, training and assessment records, and waste disposal records. The digital traceability and audit engine provides a graphical query interface, allowing users to trace the complete lifecycle of any standard product from "supplier" to "waste liquid" with a single click by scanning RFID tags or entering batch numbers. It automatically generates an audit report compliant with regulatory requirements, with all key operations in the report linked to timestamped video or data records as evidence.

[0055] In some embodiments, this application takes a dioxin analysis laboratory of an environmental testing organization as an application scenario, and deploys the complete "Intelligent Protection and Control System for Hazardous Materials in Laboratories" of this application, as follows:

[0056] 1. Overall System Deployment and Integration

[0057] like Figure 1 As shown, a unified intelligent management platform integrates five subsystems. Within the laboratory, the intelligent negative pressure operating chamber (corresponding to subsystem A) and the intelligent safe storage device (corresponding to subsystem D) are installed in the core operating area and storage area, respectively. The system data bus and central control engine, acting as the nerve center, are deployed on the server in the computer room and connected to the field controllers, sensors, and user terminals of each subsystem via the laboratory's local area network. Administrators perform global monitoring, task scheduling, and data analysis through the unified intelligent management platform (web page or client interface).

[0058] 2. Implementation details of the intelligent negative pressure control chamber

[0059] like Figure 2As shown, the intelligent negative pressure operating chamber is the core operating area of ​​this invention. 1-Chamber body, 2-Pass-through windows (2-1 large pass-through window, 2-2 small pass-through window), 3-Intelligent display screen, 4-Operating table, 5-Glove operating port, 6-Micro electronic balance, 7-Sensor series (7-1 PID sensor, 7-2 laser particle counter, 7-3 differential pressure sensor, 7-4 temperature and humidity sensor), 8-Camera (8-1 panoramic camera, 8-2 front detail camera), 9-HEPA high-efficiency particulate filter, 10-Exhaust grille, 11-Activated carbon canister, 12-Fan.

[0060] Structural Installation: The chamber 1 is constructed with a 304 stainless steel frame and a 12mm tempered glass panel. Two isobutylene glove operating ports 5 are located on the front, and two mechanically interlocked transfer windows (2-1, larger for transferring equipment, 2-2, smaller for transferring experimental materials) are installed on the right side. Structural sealing utilizes closed-cell foamed silicone or fluororubber sealing strips at all static sealing joints of the chamber, ensuring airtightness to meet system control requirements. Key dynamic sealing areas such as the glove ports and transfer window rotating shafts employ a dual sealing structure combining lip seals and magnetic seals to address the sealing challenges posed by dynamic operations, ensuring overall sealing performance meets the requirements for maintaining stable negative pressure. The intelligent negative pressure operating chamber integrates a high-precision micro-electronic balance 6. This balance is integrated into the chamber through the following design: the balance body is embedded in the stainless steel operating table and rigidly connected to the chamber frame via an active air-float vibration isolation table or a passive marble base, isolating vibration.

[0061] Airflow and differential pressure control are implemented as follows: The top air supply unit is equipped with a HEPA high-efficiency particulate filter 9, and the bottom exhaust unit is sequentially connected to an exhaust grille 10 and a dedicated activated carbon adsorption tank 11 (for dioxin adsorption). A closed-loop PID control system, consisting of a variable frequency fan 12 and differential pressure sensors 7-3, dynamically adjusts the supply and exhaust air volume to maintain a stable negative pressure gradient of -30Pa to -50Pa during operation (specific settings can be configured according to the toxicity level of the substances being handled). The airflow direction is indicated by arrows in the top-to-bottom unidirectional flow diagram.

[0062] Intelligent monitoring and graded response: Sensor arrangement: A PID sensor (VOC-001 type) 7-1 and a laser particle counter 7-2 are installed on the top of the cabin to monitor the concentration of total volatile organic compounds and particulate matter in real time, as well as the background value of the incoming air; a second PID sensor (VOC-002 type) is installed 20cm above the operating table to focus on monitoring the vapor emission at the weighing and preparation point; a differential pressure sensor and a temperature and humidity sensor 7-4 are installed on the cabin wall.

[0063] Tiered Response: The central controller is pre-configured with tiered response strategies linked to the toxicity level of substances. For example, when the PID sensor value at a focused monitoring point exceeds 1 ppm (early warning threshold), the system determines an abnormal release, automatically increases the exhaust volume by 20%, and provides an audio prompt; exceeding 5 ppm (alarm threshold), the system determines a significant risk of leakage or operational error, triggers an audible and visual alarm, and records it as an auditable event; exceeding 10 ppm (emergency threshold), it automatically locks all pass-through windows, activates the emergency exhaust mode (increasing the airflow to 150%), and simultaneously sends an alarm message to the safety administrator. These threshold settings are not specific to dioxins themselves, but rather use total volatile organic compound (TVOC) concentration as a substitute indicator to characterize the system's airtightness, operational compliance, and accident status. This is because a closed system that effectively controls solvent VOC leakage can more reliably prevent the release of dioxin-like substances with extremely low vapor pressures. For example, the occupational short-term exposure limit (PC-STEL) for toluene, a commonly used laboratory solvent, is 100 mg / m³ (approximately 26 ppm). Based on the principle of risk-based risk control, this application sets the alarm threshold within a certain percentage range (e.g., 10%-25%), i.e., 5-10 ppm. This range provides sufficient early warning of potential risks while effectively avoiding false alarms caused by background fluctuations. The threshold setting is based on general engineering practices for VOC risk-based risk management in laboratories and references the occupational exposure limits for typical organic solvents. The specific threshold value can be configured and adjusted according to the main solvents used and the laboratory safety management strategy.

[0064] Process recording: The entire process was recorded by the panoramic camera 8-1 on the top of the cabin and the front detail camera 9-2. The video stream was stored in a dedicated video recording unit and tagged with timestamps and operation task labels.

[0065] 3. Implementation details of the intelligent storage management and control subsystem

[0066] like Figure 3 As shown, the subsystem enables the refined and secure storage of high-risk standard products.

[0067] Hardware upgrade: This can be achieved by using a -20℃ dedicated low-temperature freezer as a smart and safe storage device. An electronic access lock, a built-in high-definition camera, and an RFID reader antenna can be installed on its door. High-precision temperature sensors and door magnetic sensors can be installed internally.

[0068] The dual-person, dual-lock process is implemented as follows: Two experimenters must swipe their personal identification cards and enter independent passwords at the access control terminal in turn. The dual-person authorization and access control logic unit (see...) Figure 3 The unlock command is generated only after verifying that both users have valid permissions and that the operation interval is less than 30 seconds. The built-in camera automatically starts recording video the moment the door opens, recording and storing the entire process.

[0069] RFID Lifecycle Management: Each bottle of dioxin standard stock solution is affixed with an antifreeze RFID tag, initialized with the following information: ID: DXN-2023-001, Concentration: 50 pg / μL, Expiry Date: 2024-12-31. When the stock solution is used and prepared into a working solution, a new tag is affixed to the new working solution bottle, and the preparation information (stock solution ID, dilution ratio, preparer, date) is written using a handheld RFID reader. After each use, the operator registers the usage on the management platform, and the RFID and intelligent inventory management server automatically calculates and updates the "remaining volume" information in the bottle.

[0070] Intelligent inventory logic: The server automatically tracks the expiration dates of all items, displays a "List of Items Nearing Expiration" on the management platform homepage daily, and recommends a usage order based on the "first-in, first-out" principle by default. When inventory falls below a safety threshold (e.g., <2 units), an alert email is automatically sent to the purchasing department.

[0071] 4. Implementation of the full lifecycle management process

[0072] like Figure 4 As shown, the circulation of high-risk standard products follows the following digital process:

[0073] Data entry and code assignment (corresponding) Figure 4 Steps: Warehouse Registration: After newly purchased standard products pass QC inspection, an electronic file is created on the platform, an RFID tag is affixed, and the product is scanned before being put into storage. Data is synchronized to the intelligent information traceability subsystem.

[0074] Storage and Monitoring: Items are stored in intelligent secure storage devices. Continuous monitoring and intelligent alarm module (see...) Figure 3 The temperature curve (e.g., -20℃±1℃) is continuously recorded. Any overheating or abnormal door opening event will trigger an SMS alarm to the administrator.

[0075] Issuance and Preparation: The lab technician submits an issuance request on the platform, specifying the testing item (e.g., "Soil Sample-238"). Two authorized personnel open the cabinet to collect the designated stock solution. Entering the intelligent negative pressure operating chamber, weighing, transferring, and diluting are completed under video and AI behavior recognition monitoring. The AI ​​system analyzes the standardization of pipetting actions in real time; if a serious error is detected (e.g., pipette tip not perpendicular), it corrects the error through voice prompts. Preparation data (actual weighing values, diluted concentration) is manually entered or automatically uploaded to the platform by the connected electronic balance and linked to the RFID tag of that batch of working solution.

[0076] Usage and Traceability: The working solution is used for target sample testing. The platform records its consumption and automatically links it to the initial testing project. The project leader can query the complete chain of standards used in the project with one click: purchase voucher → raw material warehousing record → storage temperature curve → dual-authorization log for requisition → preparation process video and AI report → working solution usage record.

[0077] Waste liquid disposal closed loop: The generated waste liquid is transferred to a dedicated waste liquid bottle affixed with RFID tags, and the waste liquid type, volume, and planned disposal method are registered on the platform. After a qualified unit collects and disposes of the waste liquid, the closed loop is confirmed on the platform, and the entire life cycle of the standard product officially ends in the system.

[0078] 5. Implementation of Intelligent Training and Assessment

[0079] Before starting their jobs, new employees must pass an assessment by the intelligent personnel training subsystem.

[0080] VR Immersive Training: Employees wear VR headsets and repeatedly practice standardized procedures such as "dilution of dioxin standard" in virtual scenarios. The system records their operational trajectory, step compliance, and time. Error Consequence Simulation: VR scenarios simulate the consequences of "vapor leakage due to an untightened bottle cap" to reinforce safety awareness. Practical Assessment: Employees perform actual operations in an intelligent negative pressure operating chamber. An AI behavior recognition system scores their operational compliance; only those who pass the assessment are authorized to operate independently.

[0081] 6. System linkage and intelligent traceability

[0082] The core advantage of this application lies in the intelligent linkage and data fusion between subsystems:

[0083] Example of linkage: When the intelligent storage subsystem records a standard product requisition event, the event is automatically pushed to the intelligent environmental protection subsystem, which can pre-start the negative pressure operation chamber to standby state.

[0084] Traceability Implementation: All data generated in all stages—environmental data, videos, RFID events, operation logs, training records—are automatically collected into the database of the intelligent information traceability subsystem via the system data bus. This database uses the "unique ID of the RFID tag" as an index to link all discrete data into an immutable electronic evidence chain, meeting the traceability requirements of CMA / CNAS accreditation and the "Regulations on the Safety Management of Hazardous Chemicals."

[0085] 7. System Safety and Reliability Design

[0086] To ensure the foolproof management of hazardous materials, this application incorporates the following safety and reliability designs at the system level:

[0087] (1) Data Security and Audit Trail: All sensitive data transmitted on the system data bus (including environmental sensor data, video streams, control commands, and inventory information) is encrypted using the AES-256 algorithm and transmitted through an SSL / TLS secure tunnel. All critical operational events (such as access control authorization, inventory modification, and configuration changes) generate audit logs with timestamps and operator digital signatures, which are stored in the database of the intelligent information traceability subsystem. The database implements a daily incremental backup and weekly full backup strategy, supporting off-site disaster recovery.

[0088] (2) Multi-level permissions and access control: The system implements a role-based four-level access control model: System Administrator: responsible for system configuration and maintenance; Security Officer: responsible for security policy formulation and emergency response; Operator: responsible for daily standard product storage and configuration operations; Auditor: has read-only permissions and is responsible for independent auditing and traceability. All permission changes and high-risk operations (such as dual-authorization unlocking) require two-factor authentication to ensure the controllability and traceability of operations.

[0089] (3) Key Hardware Reliability Assurance: The exhaust fan control system of the intelligent negative pressure operating chamber and the access controller of the intelligent safety storage device are all connected to an online uninterruptible power supply (UPS). After a mains power outage, the UPS can ensure the system continues to operate for at least 30 minutes, ensuring sufficient time to complete ongoing dangerous operations or initiate a safe shutdown procedure, avoiding safety risks caused by abnormal interruptions. The core server can be deployed with primary and backup redundancy.

[0090] (4) Network communication reliability: The communication network connecting each subsystem adopts an industrial-grade redundant ring network architecture or dual-link design. Any single-point line failure can be automatically switched within milliseconds to ensure the continuity of system monitoring and control and avoid blind spots in process supervision or control failure caused by network interruption.

[0091] The above embodiments, using the management of dioxin standards as an example, are described in detail only and are intended to illustrate the technical solution and implementation process of this application, and are not intended to limit this application. For those skilled in the art, several improvements and modifications can be made without departing from the principles of this application, such as: 1. By replacing or adding the sensor types of the environmental monitoring network (e.g., configuring a Geiger-Müller counter for radioactive materials, and a specific electrochemical sensor for cyanide), this system can be applied to the control of other high-risk chemicals, biotoxins, or radioactive sources.

[0092] 2. By adjusting the data model and management strategy of the intelligent information traceability subsystem, this system can be deeply integrated with the Laboratory Information Management System (LIMS), Electronic Lab Notebook (ELN), or Enterprise Resource Planning (ERP) system.

[0093] 3. Without departing from the core idea of ​​this application—achieving closed-loop intelligent management of hazardous materials throughout their entire lifecycle through deep integration of multiple systems—any modifications, equivalent substitutions, or functional expansions to the specific implementation of subsystems shall fall within the scope of protection defined by the claims of this application. These improvements and refinements shall also be considered within the scope of protection of this application.

[0094] This application adopts a modular and configurable design, and its scalability is reflected in the following three aspects:

[0095] Firstly, sensor layer expansion: the types of sensors in the environmental monitoring network can be expanded according to the characteristics of the managed materials, including but not limited to adding vibration sensors, smoke sensors, infrared sensors or specific chemical gas sensors. The newly added sensors are connected to the system data bus through a standard interface.

[0096] Secondly, system-level expansion: The intelligent information traceability subsystem is equipped with a standardized data exchange interface for data integration with the Laboratory Information Management System (LIMS).

[0097] Thirdly, application layer expansion: by adjusting the system management strategy and parameter configuration, the system and method are applicable to the intelligent management and control of the entire life cycle of other high-risk chemical standards, high-value biological standards and radioactive sources, excluding dioxins.

[0098] In some embodiments, the intelligent protection and control method for hazardous materials in laboratories based on the above-described system may include the following:

[0099] S1: Warehousing and Coding: After the standard products pass the acceptance inspection, RFID electronic tags are affixed or bound to them, and the product information (batch number, concentration, expiration date, etc.) is entered into the intelligent information traceability subsystem to complete the warehousing registration;

[0100] S2: Secure Storage: Standard products with RFID tags are stored in intelligent secure storage equipment. The system continuously monitors and records the temperature and humidity of the storage environment. All storage and retrieval operations require dual authorization and are automatically recorded. Storage and retrieval information is updated to the database in real time.

[0101] S3: Issuance and Preparation: Operators submit an issuance request on the management platform. After authorization by both parties, the smart storage device is unlocked. When items are retrieved, the RFID reader automatically identifies and records the information, and the system automatically associates this issuance with the operational tasks to be performed.

[0102] S4: Controlled Operation: The operator enters the intelligent negative pressure operating chamber. The system automatically initiates environmental monitoring and video recording. During the operation, the AI ​​behavior recognition system analyzes the operational compliance in real time and provides voice guidance or warnings. All operational details are fully recorded;

[0103] S5: Usage Record and Remaining Amount Update: After the operation is completed, the system will automatically or prompt the operator to update the preparation information and usage of the working fluid according to the preset process, and write the remaining amount information into the label of the working fluid bottle through the RFID reader.

[0104] S6: Waste Liquid Disposal Closed Loop: The generated waste liquid is placed into dedicated waste liquid bottles affixed with RFID tags, and the nature, quantity, and disposal method of the waste liquid are registered in the system. After disposal, the tag status is updated, completing the information closed loop for the entire lifecycle;

[0105] S7: Full traceability and auditing: At any stage, authorized personnel can query the entire process information chain of any standard product through the system and export a structured audit report;

[0106] The embodiments described above are merely illustrative of several implementation methods of this application, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the invention patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this application, and these all fall within the protection scope of this application. Therefore, the protection scope of this patent application should be determined by the appended claims. The selected and described embodiments are intended to best elucidate the principles of this application and its practical application, thereby enabling other those skilled in the art to best utilize this application with various modifications suitable for the contemplated specific purpose, as well as the various described embodiments.

Claims

1. A laboratory hazardous materials protection and control system, characterized in that, include: The environmental protection subsystem includes a negative pressure operating chamber and a multi-parameter environmental monitoring network; the negative pressure operating chamber is used to provide a physically isolated and clean operating environment, and the multi-parameter environmental monitoring network is used to monitor the environmental safety status in real time. The process monitoring subsystem is used for full-process visual recording and behavioral analysis of experimental operations via video surveillance. The subsystem includes a multi-angle high-definition video monitoring unit and a behavior recognition and analysis server. The multi-angle high-definition video monitoring unit includes a panoramic camera and a detail camera deployed in the negative pressure operating chamber. The panoramic camera monitors the operator's full-body posture and the overall environment inside the chamber, while the detail camera focuses on monitoring micro-movements during key operations. The behavior recognition and analysis server is connected to the multi-angle high-definition video monitoring unit and has a built-in behavior recognition model trained based on deep learning algorithms. This model analyzes the video stream to identify operational compliance, abnormal events, and safety compliance. The personnel training subsystem is used to provide standardized and immersive skills training and assessment for operators. The personnel training subsystem includes a VR / AR immersive training platform, which includes VR head-mounted displays and / or AR glasses, a standardized operation training module for 3D simulation, an emergency response drill module, an error operation warning module, and a training management and assessment module. The storage control subsystem is used for the storage and control of hazardous materials. The storage control subsystem includes storage devices and an RFID lifecycle tagging system. The storage devices include a dual-person, dual-lock electronic access control system, door status monitoring sensors, an uninterruptible power supply, and a built-in video recording unit. The RFID lifecycle tagging system affixes an RFID electronic tag to each hazardous material, and the RFID electronic tag stores the unique identification information of the corresponding hazardous material. An inventory management server is connected to the storage device and the RFID reader / writer of the RFID lifecycle tag system, and is used for automatic inventory counting and ledger updates based on RFID data. as well as The information traceability subsystem includes a full-process database and a digital traceability audit engine; the full-process database is used to structure and store all data from each subsystem; the digital traceability audit engine is used to provide a graphical query interface.

2. The laboratory hazardous materials protection and control system according to claim 1, characterized in that: The negative pressure operating chamber includes a sealed chamber consisting of a stainless steel frame and a transparent protective panel. The front of the sealed chamber is provided with a glove operating port, and the side is provided with an interlocked transfer window. The sealed chamber establishes and maintains a working negative pressure. The multi-parameter environmental monitoring network includes an ionization detector for monitoring the concentration of volatile organic compounds, a laser particle counter for monitoring the concentration of aerosol particles, a temperature and humidity sensor for monitoring the temperature and humidity inside the cabin, and a differential pressure sensor for real-time monitoring of the pressure difference between the inside and outside of the cabin. The environmental protection subsystem also includes an emergency response controller, which is connected to the multi-parameter environmental monitoring network. The emergency response controller is pre-set with a graded response strategy, which includes: automatically increasing the exhaust volume and providing a voice prompt when the organic compound concentration monitoring value reaches the warning threshold; triggering an audible and visual alarm and recording the event when the organic compound concentration monitoring value reaches the alarm threshold; and automatically locking the pass-through window and automatically increasing the exhaust volume by more than double and sending an alarm message when the organic compound concentration monitoring value reaches the emergency threshold.

3. The laboratory hazardous materials protection and control system according to claim 1, characterized in that: The graphical query interface is used to trace the complete life cycle of hazardous materials and automatically generate reports, which are associated with timestamped video or data records.

4. The laboratory hazardous materials protection and control system according to claim 1, characterized in that: The dual-person dual-lock electronic access control system includes a dual-person authorization and access control logic unit; the dual-person authorization and access control logic unit generates an unlocking command based on the fact that two operators swipe their personal ID cards and enter independent passwords on the access control terminal in turn, and that the operation interval is less than a preset time after verifying that the permissions of both people are valid.

5. The laboratory hazardous materials protection and control system according to claim 2, characterized in that: All static sealing joints in the sealed chamber are equipped with sealing strips; the rotating shaft dynamic sealing parts of the glove operating port and transfer window adopt a double sealing structure combining lip seal and magnetic seal; the negative pressure operating chamber also includes an electronic balance, the main body of which is embedded in a stainless steel operating table and connected to the sealed chamber through an active air-float vibration isolation table or a passive marble base.

6. The laboratory hazardous materials protection and control system according to claim 2, characterized in that: The top air supply unit of the sealed chamber is equipped with a HEPA high-efficiency particulate filter, and the bottom exhaust unit is connected in sequence to the exhaust grille and the activated carbon adsorption tank. The sealed chamber is also equipped with a variable frequency fan, and the exhaust volume is dynamically adjusted by a closed-loop PID control system consisting of the variable frequency fan and the differential pressure sensor.

7. The laboratory hazardous materials protection and control system according to claim 1, characterized in that: It also includes a management platform and system data bus, and a central control engine. The management platform is coupled to the environmental protection subsystem, process monitoring subsystem, personnel training subsystem, storage control subsystem, inventory management server and information traceability subsystem through the system data bus and the central control engine, respectively.

8. The laboratory hazardous materials protection and control system according to claim 1, characterized in that: The operational standards include the pipette holding angle, the order of opening the bottle cap, and the mixing technique; the abnormal events include liquid spillage and container tipping; the safety compliance includes whether the required protective equipment is worn and whether there is fatigue during operation.

9. The laboratory hazardous materials protection and control system according to claim 1, characterized in that: The unique identification information includes: substance name, batch number, concentration, expiration date, storage location, preparation record, remaining amount, and disposal status.

10. A method for protecting and controlling hazardous materials in a laboratory using the laboratory hazardous materials protection and control system as described in any one of claims 1-9, characterized in that, include: After the hazardous materials pass inspection, RFID electronic tags are affixed or bound to them, and the information of the hazardous materials is entered into the information traceability subsystem to complete the warehousing registration. Safe storage involves storing hazardous materials with RFID tags in a safe storage device, and then continuously monitoring and recording the temperature and humidity of the storage environment. This storage and retrieval operation requires authorization from two people and is automatically recorded. The storage and retrieval information is updated to the full-process database in real time. For requisition and preparation, the operator submits a requisition application, and the storage device is unlocked after authorization by two people. When the operator takes out hazardous materials, the RFID reader automatically identifies and records them, associating them with the operation task to be performed during this requisition. Controlled operation: The operator enters the negative pressure operating chamber, and then the negative pressure operating chamber automatically starts environmental monitoring and video recording; During the operator's operation, the behavior recognition and analysis server analyzes the standardization of the operation in real time and provides voice guidance or warnings. All operation details are fully recorded. After the operation is completed, update the preparation information and usage of hazardous materials, and write the remaining information into the tag using an RFID reader. The waste liquid disposal closed loop involves placing the generated waste liquid into waste liquid bottles with RFID tags, and registering the nature, quantity, and disposal method of the waste liquid. After disposal, the tag status is updated to complete the information closed loop of the entire life cycle. Full traceability and auditing: Operators can query the entire information chain of hazardous materials through a graphical query interface and export structured reports.

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