Embryo sample management method based on dynamic adjustment of pregnancy progress

Abstract

The application discloses a kind of embryo sample management methods based on dynamic adjustment of pregnancy progress, specifically related to medical instrument technical field, the present frozen embryo storage system is statically managed mode, it is difficult to quickly locate the problem of thawed embryo after pregnancy failure, the present application is with embryo transplantation day as time reference to start timing, obtain pregnancy detection result at multiple pregnancy time nodes of preset, when result indicates pregnancy failure, automatically adjust thawed embryo to quick call storage area and realize quick call;When clinical pregnancy is successful, embryo is sealed to seal storage area;When live birth is successful, further transfer to spare liquid nitrogen tank long-term preservation.The present application is by constructing three-level progressive storage system, according to the different pregnancy time nodes of pregnancy progress, automatically adjust embryo storage location, realize the quick positioning and calling of thawed embryo, significantly improve the clinical response efficiency of thawing transplantation and the space utilization of frozen embryo bank.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and more specifically, to a method for managing embryo samples based on dynamic adjustment of pregnancy progress. Background Technology

[0002] Currently, with the widespread adoption of assisted reproductive technology (ART), the number of frozen embryo samples is increasing dramatically. To address this challenge, various automated embryo storage devices with automatic loading and unloading, precise sample positioning, and track scheduling functions have emerged on the market (such as the cryovial aspiration device disclosed in CN112090469B and the automated biobank temperature control method disclosed in CN112189657B). These devices can achieve independent identification and precise placement of individual cryovials, upgrading traditional manual storage and retrieval to automated and information-based physical control of samples.

[0003] However, the core management logic of the aforementioned automated storage devices and their supporting management systems remains a static storage model where embryos are placed in a fixed location upon entry into the storage facility. In clinical scenarios where pregnancy failure necessitates the initiation of frozen embryo transfer, this static model presents several problems: the system cannot dynamically prioritize embryos based on pregnancy test results; the most suitable high-quality embryos for thawing are stored alongside a large number of low-priority embryos in the same area for extended periods; embryos not used for extended periods occupy valuable storage space in the automated storage devices; medical staff struggle to quickly locate and retrieve embryos awaiting thawing; the operational procedures are complex; and the response time is slow, severely impacting the clinical efficiency of frozen embryo transfer.

[0004] Therefore, this invention proposes an embryo sample management method based on dynamic adjustment of pregnancy progress, which further improves the existing embryo sample management method; so as to automatically adjust the storage location of embryos according to pregnancy test results, realize the rapid location and retrieval of embryos to be thawed, and significantly improve the clinical response efficiency of thawed transplantation. Summary of the Invention

[0005] To overcome the aforementioned deficiencies of the prior art, embodiments of the present invention provide an embryo sample management method based on dynamic adjustment of pregnancy progress, in order to solve the problems mentioned in the background art.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a method for managing embryo samples based on dynamic adjustment of pregnancy progress, comprising the following steps: S1: Score and rank all of the patient's embryos for quality. S2: Store the data in multiple preset storage areas according to the rating from high to low; S3: Start timing based on the embryo transfer date; S4: Obtain pregnancy test results corresponding to each preset pregnancy time point; S5: If the pregnancy test result indicates a successful pregnancy, then according to the time node type corresponding to the pregnancy test result, perform the corresponding storage operation on the patient's remaining embryos; If the pregnancy test result indicates a failed pregnancy, determine whether there are still frozen embryos: if so, adjust the embryos to be thawed to the preset storage area according to the time node type corresponding to the pregnancy test result; if not, terminate the current management process.

[0007] Furthermore, in S4, multiple pregnancy time points include: the biochemical pregnancy test point on the 14th day after embryo transfer, the clinical pregnancy test point on the 75th day after embryo transfer, and the live birth test point on the 280th day after embryo transfer.

[0008] Furthermore, the S2 includes multiple preset storage areas such as a first storage area, a second storage area, a third storage area, a quick recall storage area, a sealed storage area, and a spare liquid nitrogen tank; the remaining untransferable embryos are stored in the first storage area, the second storage area, and the third storage area in descending order of their scores. When the pregnancy test result of the patient's transferred embryo is unsuccessful, the quick recall storage area stores the frozen embryos transferred from the first storage area or the sealed storage area. When the pregnancy test result at the clinical pregnancy test node of the patient's embryo transfer is successful, the sealed storage area stores all the remaining frozen embryos of the patient; When the pregnancy test result at the live birth detection node of the patient's transferred embryo indicates success, the backup liquid nitrogen tank stores and seals all frozen embryos in the storage area.

[0009] Furthermore, before S3, the process includes: determining whether a timer has been started; if not, selecting the highest priority embryo for thawing and transfer; specifically, selecting the highest priority embryo for thawing and transfer includes: first selecting the highest-scoring embryo in the first storage area and storing it in a preset quick-access storage area; then retrieving the embryo to be thawed from the quick-access storage area and performing the thawing and transfer operation.

[0010] Furthermore, in step S5, if the pregnancy test result of the biochemical pregnancy test node indicates success, the storage area where the embryo is located remains unchanged. If the pregnancy test result at the aforementioned clinical pregnancy test node indicates success, all remaining frozen embryos of the patient will be transferred to the sealed storage area. If the pregnancy test result at the live birth detection node indicates success, all frozen embryos in the sealed storage area will be transferred to a backup liquid nitrogen tank for long-term storage. If the pregnancy test result at the biochemical pregnancy test node or the clinical pregnancy test node indicates a failure, the specific steps for adjusting the embryos to be thawed to the fast-access storage area include: S51: Transfer the entire embryo from the first storage area to the fast-access storage area; S52: Transfer the entire embryo from the second storage area to the first storage area; S53: Transfer the embryo with the highest score in the third storage area to the second storage area; If the pregnancy test result of the live birth detection node indicates a failed live birth, the specific steps for adjusting the embryos to be thawed to the fast-access storage area include: S54: Remove all embryos from the sealed storage area, perform quality scoring, and sort them; S55: According to the score from high to low, the embryos are stored in the quick recall storage area, the first storage area, the second storage area and the third storage area in sequence, and the embryo with the highest score is stored in the quick recall storage area as the embryo to be thawed.

[0011] An embryo sample management system applying the above-described embryo sample management method includes: The embryo transfer timing module is configured to generate a timing start signal based on the embryo transfer date. The pregnancy information reading module has its input end connected to the output end of the embryo transfer timing module. The pregnancy information reading module is configured to receive the timing start signal and generate and output pregnancy test result signals corresponding to each time point at multiple preset pregnancy time points. A dynamic decision-making and response module, the input of which is connected to the output of the pregnancy information reading module, is configured to receive the pregnancy test result signal; The embryo scoring and ranking module is configured to score and rank all of the patient's embryos and generate a ranking result signal. An embryo partitioning storage module, the input of which is connected to the output of the embryo scoring and sorting module; The storage unit includes: a first storage area, a second storage area, a third storage area, a fast recall storage area, a sealed storage area, and a spare liquid nitrogen tank; The dynamic decision-making and response module is further configured to generate and output a partition adjustment instruction when the pregnancy test result signal indicates pregnancy failure. The partition adjustment instruction includes an instruction to adjust the embryo to be thawed to the fast recall storage area. The embryo partition storage module is further configured to: receive the sorting result signal, and according to the sorting result signal, store the untransplanted embryos sequentially into the first storage area, the second storage area, and the third storage area in descending order of scores.

[0012] Furthermore, the dynamic decision-making and response module is further configured to generate a first migration instruction, a second migration instruction, and a third migration instruction when the pregnancy test result signal indicates a biochemical pregnancy failure or a clinical pregnancy failure. The first migration instruction is configured to instruct the entire embryo currently stored in the first storage area to be migrated to the fast-access storage area; The second migration instruction is configured to instruct the entire embryo currently stored in the second storage area to be migrated to the first storage area; The third migration instruction is configured to instruct the highest-scoring embryo currently stored in the third storage area to be migrated to the second storage area.

[0013] Furthermore, the dynamic decision-making and response module is further configured to: when the pregnancy detection result signal output by the live birth detection node received by the pregnancy information reading module indicates a live birth failure, generate a reallocation instruction. The reallocation instruction is configured to instruct all embryos in the sealed storage area to be taken out, scored and sorted, and then stored in the quick recall storage area, the first storage area, the second storage area and the third storage area in order of score from high to low, wherein the embryo with the highest score is stored in the quick recall storage area as an embryo to be thawed.

[0014] Furthermore, the dynamic decision-making and response module is further configured to: when the pregnancy test result signal output by the pregnancy information reading module at the clinical pregnancy test node indicates that the pregnancy is successful, generate a sealing instruction, the sealing instruction being configured to instruct all of the patient's frozen embryos to be uniformly transferred to the sealing storage area; The dynamic decision-making and response module is further configured to generate a long-term storage instruction when the pregnancy information reading module outputs a pregnancy test result signal at the live birth detection node indicating a successful live birth. The long-term storage instruction is configured to instruct all frozen embryos in the sealed storage area to be transferred to the backup liquid nitrogen tank.

[0015] A computer-readable storage medium having a computer program stored thereon, which, when executed by a processor, implements the above-described method for managing embryo samples based on dynamic adjustment of pregnancy progress.

[0016] The technical effects and advantages of this invention are as follows: 1. Compared with existing technologies, the method, system, and storage medium provided by this invention first score, sort, and store embryos in separate zones. Before implantation, the optimal embryo is dynamically selected and stored in a rapid-access storage area for thawing and implantation. In the event of pregnancy failure, the optimal embryo to be thawed is automatically moved to the rapid-access storage area, achieving centralized storage and rapid location of embryos to be thawed. Compared with the static management model of existing technologies where embryos are fixed in location after storage and require manual screening after pregnancy failure, this invention can automatically trigger dynamic adjustments to embryo storage locations based on pregnancy test results. Medical staff do not need to search through a large number of frozen samples one by one; they can directly thaw and retrieve embryos from the rapid-access storage area. This significantly simplifies the procedure for repeated implantation, shortens clinical preparation time, effectively solves the technical problem of difficulty in quickly locating embryos to be thawed after pregnancy failure in existing technologies, and greatly improves the clinical response efficiency of assisted reproductive treatment.

[0017] 2. Compared with existing technologies, this system pre-grades and stores embryos based on quality scores, and dynamically adjusts the priority of embryos in case of pregnancy failure by migrating them from the first storage area to the quick-access storage area, from the second storage area to the first storage area, and from the third storage area to the second storage area. This ensures that embryos awaiting thawing are always the highest priority and maintains a complete and continuous priority system for remaining embryos, facilitating multiple reuses. By transferring all embryos to the sealed storage area upon successful clinical pregnancy, core storage space is released promptly, preventing low-frequency samples from occupying high-priority areas for extended periods, significantly improving the space utilization efficiency of the frozen embryo bank. After a successful live birth, embryos are further transferred to a backup liquid nitrogen tank for long-term preservation, achieving tiered and long-term sample management. In the event of a failed live birth with remaining embryos, the quick-access storage area can be reactivated and embryos redistributed across storage areas, achieving a closed-loop management cycle. Furthermore, the system synchronously updates the sample storage status database throughout the process, recording the complete transfer trajectory of embryos, providing traceable data support for clinical decision-making, and further ensuring the standardization and security of sample management. Attached Figure Description

[0018] Figure 1 This is a flowchart of the method of the present invention.

[0019] Figure 2 This is a schematic diagram of the system of the present invention.

[0020] Figure 3 This is a schematic diagram of the composition of the storage unit in the system of the present invention.

[0021] The attached diagram is labeled as follows: 1. Embryo transfer timing module; 2. Pregnancy information reading module; 3. Dynamic decision-making and response module; 4. Embryo scoring and sorting module; 5. Embryo partition storage module; 6. First storage area; 7. Second storage area; 8. Third storage area; 9. Quick recall storage area; 10. Sealed storage area; 11. Backup liquid nitrogen tank. Detailed Implementation

[0022] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the invention. The method of this invention is executed by a computer program or dedicated hardware module, with each step based on data signal transmission and control, representing an improvement to the internal information processing flow of cryogenic embryo storage devices.

[0023] It should be noted that the embryo quality scoring criteria involved in this invention are common knowledge in the field of assisted reproductive technology. Those skilled in the art can use conventional methods such as morphological scoring, blastocyst grading, or time-varying culture kinetic parameters to assess and rank embryos, without needing to limit specific scoring thresholds or algorithms in this invention. Furthermore, the first storage area, second storage area, third storage area, sealed storage area, and spare liquid nitrogen tank can each store one or more embryos. The specific number stored is determined by the patient's remaining embryo count and the physical capacity of the storage equipment, and can be flexibly configured according to actual clinical conditions. Typically, the quick-access storage area is used for temporary storage of embryos awaiting thawing, storing one embryo at a time. The above implementation details do not constitute a limitation on the scope of this invention.

[0024] To achieve the aforementioned logical partitioning, in a preferred embodiment of the present invention, the storage unit adopts a tray-type cryopreservation architecture. Specifically, the cryopreservation embryo storage device has multiple physical trays, such as 20 trays, each tray holding one or more frozen embryo samples. All trays are logically divided into five storage areas: the first storage area 6 corresponds to trays 1 to 3, used to store the highest-scoring and most reuse-priority spare embryos in the current cycle; the second storage area 7 corresponds to trays 4 to 6, used to store embryos with the next highest scores; the third storage area 8 corresponds to trays 7 to 9, used to store other embryos with a lower probability of recent use; the quick-access storage area 9 corresponds to trays 10 to 12, serving as a buffer zone for temporarily storing embryos about to be thawed; and the sealed storage area 10 corresponds to trays 13 to 20, used to store embryos that have entered a stable phase after successful clinical pregnancy. The boundaries between each logical partition are dynamically adjusted according to pregnancy progress, without the need for physical barriers.

[0025] The backup liquid nitrogen tank 11 is an independently movable cryogenic storage device. It has internal tray slots that match the storage device, used to receive trays transferred as a whole from the sealed storage area 10. When a live birth is successful, the system transfers trays 13 to 20 corresponding to the sealed storage area 10 to the backup liquid nitrogen tank 11. When a live birth fails and the sealed storage area needs to be reactivated, the system can retrieve the required trays from the backup liquid nitrogen tank 11 to the sealed storage area 10 individually, and then allocate them to the quick-access storage area 9 or other areas according to the partitioning adjustment command.

[0026] The above tray division method is only an example. In actual configuration, the number of storage areas, the number of trays and their corresponding relationships can be flexibly adjusted according to the specific specifications of the storage device. All equivalent transformations made in accordance with the principles of this invention fall within the protection scope of this invention.

[0027] Example 1: As attached Figure 1 As shown, this embodiment provides a method for managing embryo samples based on dynamic adjustment of pregnancy progress, including the following steps: S1: Quality scoring and sorting of all embryos for the patient: At the start of the treatment cycle, the embryo scoring and sorting module 4 assesses the quality of all embryo samples obtained by the patient and sorts all embryos from high to low scores based on the assessment results; then all embryos are cryopreserved and each embryo is uniquely coded and managed. S2: According to the score from high to low, store them into multiple preset storage areas; the embryo partition storage module 5 stores the remaining embryos with the highest score in the first storage area 6, the embryos with the second highest score in the second storage area 7, and the remaining embryos in the third storage area 8. Determine if the timer has been started; if not, select the highest priority embryo for thawing and transfer; first select the embryo with the highest score in the first storage area 6 and store it in the preset quick recall storage area 9; then retrieve the embryo to be thawed from the quick recall storage area 9 and perform the thawing and transfer operation; then return to continue the determination until the transfer is completed and enter S3; if it has been started, directly enter S3. S3: Start timing based on the embryo transfer date, and record it as day 0, which means the initial transfer has been completed or subsequent transfers are in progress; S4: At multiple preset pregnancy time points, such as the biochemical pregnancy test on day 14 post-transfer, the clinical pregnancy test on day 75 post-transfer, and the live birth status test on day 280 post-transfer, the pregnancy test results corresponding to each time point are obtained; that is, the pregnancy information reading module 2 obtains the pregnancy test results corresponding to each time point and generates a pregnancy test result signal. S5: Dynamic decision-making and response module 3 judges the pregnancy test results obtained from multiple pregnancy time points set in S4: If the pregnancy test result indicates a successful pregnancy, then the corresponding storage operation is performed on the patient's remaining embryos according to the time node type corresponding to the pregnancy test result. If the pregnancy test result indicates a failed pregnancy, it is determined whether there are still frozen embryos: if so, the embryos to be thawed are moved to the preset storage area according to the time node type corresponding to the pregnancy test result; if not, the current management process is terminated. Specifically, when the countdown reaches day 14, the pregnancy information reading module 2 triggers a biochemical pregnancy test to read the patient's HCG test results. If the biochemical pregnancy test result indicates success, the storage location of all remaining frozen embryos remains unchanged, i.e., the sample location remains the same, and the patient continues to wait until day 75. If the test result is abnormal, i.e., pregnancy has failed, the embryos to be thawed are moved to the quick-access storage area: S51: The embryos in the first storage area are moved to the quick-access storage area; S52: The embryos in the second storage area are moved to the first storage area; S53: The embryo with the highest score in the third storage area is moved to the second storage area. When the countdown reaches day 75, the pregnancy information reading module 2 triggers a clinical pregnancy test, such as checking whether the embryo has implanted and has a fetal heartbeat. If the pregnancy test result at the clinical pregnancy test node indicates success, all remaining frozen embryos of the patient are transferred to the sealed storage area 10; then, the patient continues to wait for day 280. If the test result is abnormal, i.e., the pregnancy has failed, the embryos to be thawed are moved to the quick-access storage area: S51: the embryos in the first storage area are moved to the quick-access storage area; S52: the embryos in the second storage area are moved to the first storage area; S53: the embryo with the highest score in the third storage area is moved to the second storage area. When the countdown reaches day 280, the pregnancy information reading module 2 triggers a detection of the fetal delivery status. If the pregnancy detection result of the live birth detection node indicates success, all frozen embryos in the sealed storage area are transferred to a backup liquid nitrogen tank for long-term storage; if the detection result indicates no live birth, i.e., live birth failed, the embryos to be thawed are moved to the quick-access storage area, and S54 is executed: all embryos are taken out from the sealed storage area, quality is scored and sorted; S55: according to the score from high to low, the embryos are stored sequentially in the quick-access storage area, the first storage area, the second storage area and the third storage area, with the embryo with the highest score stored in the quick-access storage area as the embryo to be thawed.

[0028] If no frozen embryos are found, the current management process will be terminated.

[0029] Example 2: This embodiment proposes an embryo sample management system that applies the above-described embryo sample management method, as shown in the attached figure. Figure 2 and attached Figure 3 As shown, it specifically includes: an embryo transfer timing module 1, a pregnancy information reading module 2, a dynamic decision-making and response module 3, an embryo scoring and sorting module 4, an embryo partition storage module 5, and a storage unit; the storage unit includes: a first storage area 6, a second storage area 7, a third storage area 8, a fast recall storage area 9, a sealed storage area 10, and a spare liquid nitrogen tank 11.

[0030] The embryo transfer timing module 1 is configured to generate a timing start signal based on the embryo transfer date. The input of the pregnancy information reading module 2 is connected to the output of the embryo transfer timing module 1. The pregnancy information reading module 2 is configured to receive the timing start signal and generate and output pregnancy test result signals corresponding to each preset pregnancy time node. The input of the dynamic decision-making and response module 3 is connected to the output of the pregnancy information reading module 2. The dynamic decision-making and response module 3 is configured to receive the pregnancy test result signal and generate corresponding partition adjustment instructions. The embryo scoring and sorting module 4 is configured to score and sort all the patient's embryos and generate a sorting result signal. The input of the embryo partition storage module 5 is connected to the output of the embryo scoring and sorting module 4. The embryo partition storage module 5 is further configured to receive the sorting result signal and, according to the sorting result signal, store the untransferred embryos in the first storage area 6, the second storage area 7, and the third storage area 8 in descending order of score.

[0031] The dynamic decision-making and response module 3 is further configured to generate and output a partition adjustment instruction when the pregnancy test result indicates pregnancy failure. The partition adjustment instruction includes an instruction to adjust the embryo to be thawed to the fast-access storage area 9.

[0032] The dynamic decision-making and response module 3 is further configured to generate a first migration instruction, a second migration instruction, and a third migration instruction when the pregnancy test result signal indicates a biochemical pregnancy failure or a clinical pregnancy failure. The first migration instruction is configured to instruct the entire embryo currently stored in the first storage area 6 to be migrated to the quick recall storage area 9. The second migration instruction is configured to instruct the entire embryo currently stored in the second storage area 7 to be migrated to the first storage area 6. The third migration instruction is configured to instruct the embryo with the highest score currently stored in the third storage area 8 to be migrated to the second storage area 7.

[0033] The dynamic decision-making and response module 3 is further configured to: when the pregnancy detection result signal output by the live birth detection node received by the pregnancy information reading module 2 indicates that the live birth has failed, generate a reallocation instruction. The reallocation instruction is configured to instruct all embryos in the sealed storage area 10 to be taken out, scored and sorted, and then stored in the quick recall storage area 9, the first storage area 6, the second storage area 7 and the third storage area 8 in order of score from high to low. The embryo with the highest score is stored in the quick recall storage area 9 as an embryo to be thawed.

[0034] The dynamic decision-making and response module 3 is further configured to generate a sealing instruction when the pregnancy test result signal output by the pregnancy information reading module 2 at the clinical pregnancy test node indicates that the pregnancy is successful. The sealing instruction is configured to instruct all of the patient's frozen embryos to be transferred to the sealing storage area 10.

[0035] The dynamic decision-making and response module 3 is further configured to generate a long-term storage instruction when the pregnancy detection result signal output by the pregnancy information reading module 2 at the live birth detection node indicates that the live birth was successful. The long-term storage instruction is configured to instruct all frozen embryos in the sealed storage area 10 to be transferred to the standby liquid nitrogen tank 11.

[0036] Example 3: This example provides a computer-readable storage medium on which a computer program is stored. When the computer program is executed by a processor, it implements the embryo sample management method based on dynamic adjustment of pregnancy progress described in Example 1. The storage medium can be any medium capable of storing program code, such as ROM, RAM, hard disk, optical disk, or USB flash drive.

[0037] Working principle of the invention: The invention establishes a timing mechanism based on the day of embryo transfer and presets multiple pregnancy time nodes during system initialization (chemical pregnancy detection on day 14, clinical pregnancy detection on day 75, and live birth detection on day 280). The pregnancy information reading module 2 automatically obtains the detection results of each node, and the dynamic decision and response module 3 judges the detection results.

[0038] Before the transfer, the system selects the best embryo from the first storage area 6 and places it into the fast-access storage area 9 for thawing and transfer.

[0039] During post-implantation monitoring, when test results indicate pregnancy failure, the system automatically triggers a zoning adjustment command: For biochemical or clinical pregnancy failure, the first storage zone 6, where the current high-priority reserve embryos are located, is moved to the rapid recall storage zone 9. At the same time, embryos in the second storage zone 7 and the third storage zone 8 are moved forward in order of their scores to maintain the continuity of the priority system. For live birth failure, all embryos are retrieved from the sealed storage zone 10, re-scored and sorted, and the highest-scoring embryo is stored in the rapid recall storage zone 9, with the rest stored in the first to third storage zones in order. After the adjustment is completed, the embryos in the rapid recall storage zone 9 are thawed and transferred again, forming a closed loop. This achieves centralized storage and rapid location of embryos to be thawed.

[0040] When the test results indicate a successful clinical pregnancy, the system seals all embryos in the sealed storage area 10, releasing the core storage space. Upon successful live birth, the embryos are further transferred to a backup liquid nitrogen tank 11 for long-term preservation. The entire management process records the complete flow trajectory of the embryos through a sample storage status database, forming a closed-loop traceable management system. Based on the above working principle, this invention solves the technical problem of difficulty in quickly locating embryos to be thawed after pregnancy failure in existing technologies, significantly improving the clinical response efficiency of thawed embryo transfer and the space utilization rate of the frozen embryo bank.

[0041] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0042] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A method for managing embryo samples based on dynamic adjustment of pregnancy progress, characterized in that, Includes the following steps: S1: Score and rank all of the patient's embryos for quality. S2: Store the data in multiple preset storage areas according to the rating from high to low; S3: Start timing based on the embryo transfer date; S4: Obtain pregnancy test results corresponding to each preset pregnancy time point; S5: If the pregnancy test result indicates a successful pregnancy, then according to the time node type corresponding to the pregnancy test result, perform the corresponding storage operation on the patient's remaining embryos; If the pregnancy test result indicates a failed pregnancy, determine whether there are still frozen embryos: if so, adjust the embryos to be thawed to the preset storage area according to the time node type corresponding to the pregnancy test result; if not, terminate the current management process.

2. The embryo sample management method based on dynamic adjustment of pregnancy progress according to claim 1, characterized in that: In S4, multiple pregnancy time points include: the biochemical pregnancy test point on the 14th day after embryo transfer, the clinical pregnancy test point on the 75th day after embryo transfer, and the live birth test point on the 280th day after embryo transfer.

3. The embryo sample management method based on dynamic adjustment of pregnancy progress according to claim 2, characterized in that: The S2 includes multiple preset storage areas, such as a first storage area, a second storage area, a third storage area, a quick recall storage area, a sealed storage area, and a spare liquid nitrogen tank. The remaining untransferable embryos are stored in the first storage area, the second storage area, and the third storage area in descending order of their scores. When the pregnancy test result of the patient's transferred embryo is unsuccessful, the quick recall storage area stores the frozen embryos transferred from the first storage area or the sealed storage area. When the pregnancy test result at the clinical pregnancy test node of the patient's embryo transfer is successful, the sealed storage area stores all the remaining frozen embryos of the patient; When the pregnancy test result at the live birth detection node of the patient's transferred embryo indicates success, the backup liquid nitrogen tank stores and seals all frozen embryos in the storage area.

4. The embryo sample management method based on dynamic adjustment of pregnancy progress according to claim 3, characterized in that: Before step S3, the process further includes: determining whether timing has been started; if not, first selecting the embryo with the highest score in the first storage area and storing it in a preset quick-access storage area; then retrieving the embryo to be thawed from the quick-access storage area and performing the thaw and transfer operation.

5. The embryo sample management method based on dynamic adjustment of pregnancy progress according to claim 3, characterized in that: In step S5, if the pregnancy test result of the biochemical pregnancy test node indicates success, the storage area where the embryo is located remains unchanged. If the pregnancy test result at the aforementioned clinical pregnancy test node indicates success, all remaining frozen embryos of the patient will be transferred to the sealed storage area. If the pregnancy test result at the live birth detection node indicates success, all frozen embryos in the sealed storage area will be transferred to a backup liquid nitrogen tank for long-term storage. If the pregnancy test result at the biochemical pregnancy test node or the clinical pregnancy test node indicates a failure, the specific steps for adjusting the embryos to be thawed to the fast-access storage area include: S51: Transfer the entire embryo from the first storage area to the fast-access storage area; S52: Transfer the entire embryo from the second storage area to the first storage area; S53: Transfer the embryo with the highest score in the third storage area to the second storage area; If the pregnancy test result of the live birth detection node indicates a failed live birth, the specific steps for adjusting the embryos to be thawed to the fast-access storage area include: S54: Remove all embryos from the sealed storage area, perform quality scoring, and sort them; S55: According to the score from high to low, the embryos are stored in the quick recall storage area, the first storage area, the second storage area and the third storage area in sequence, and the embryo with the highest score is stored in the quick recall storage area as the embryo to be thawed.

6. An embryo sample management system applying the embryo sample management method according to any one of claims 1-5, characterized in that, include: The embryo transfer timing module (1) is configured to generate a timing start signal based on the embryo transfer date. The pregnancy information reading module (2) has its input end connected to the output end of the transplant timing module (1). The pregnancy information reading module (2) is configured to receive the timing start signal and generate and output pregnancy test result signals corresponding to each time node at multiple preset pregnancy time nodes. The dynamic decision and response module (3) has its input end connected to the output end of the pregnancy information reading module (2), and the dynamic decision and response module (3) is configured to receive the pregnancy test result signal; Embryo scoring and ranking module (4), which is configured to score and rank all of the patient’s embryos and generate ranking result signals; The embryo partition storage module (5) has its input end connected to the output end of the embryo scoring and sorting module (4); The storage unit includes: a first storage area (6), a second storage area (7), a third storage area (8), a fast recall storage area (9), a sealed storage area (10), and a spare liquid nitrogen tank (11). The dynamic decision and response module (3) is further configured to generate and output a partition adjustment instruction when the pregnancy test result signal indicates pregnancy failure. The partition adjustment instruction includes an instruction to adjust the embryo to be thawed to the fast recall storage area (9). The embryo partition storage module (5) is further configured to: receive the sorting result signal, and according to the sorting result signal, store the untransplanted embryos into the first storage area (6), the second storage area (7) and the third storage area (8) in order of score from high to low.

7. The embryo sample management system according to claim 6, characterized in that: The dynamic decision and response module (3) is further configured to generate a first migration instruction, a second migration instruction and a third migration instruction when the pregnancy test result signal indicates a biochemical pregnancy failure or a clinical pregnancy failure. The first migration instruction is configured to instruct the entire embryo currently stored in the first storage area (6) to be migrated to the fast recall storage area (9). The second migration instruction is configured to instruct the entire embryo currently stored in the second storage area (7) to be migrated to the first storage area (6); The third migration instruction is configured to instruct the highest-scoring embryo currently stored in the third storage area (8) to be migrated to the second storage area (7).

8. The embryo sample management system according to claim 6, characterized in that: The dynamic decision and response module (3) is further configured to: when the pregnancy detection result signal output by the live birth detection node received by the pregnancy information reading module (2) indicates that the live birth has failed, generate a reallocation instruction. The reallocation instruction is configured to instruct all embryos in the sealed storage area (10) to be taken out, quality scored and sorted, and then stored in the quick recall storage area (9), the first storage area (6), the second storage area (7) and the third storage area (8) in order of score from high to low. The embryo with the highest score is stored in the quick recall storage area (9) as an embryo to be thawed.

9. The embryo sample management system according to claim 6, characterized in that: The dynamic decision and response module (3) is further configured to generate a sealing instruction when the pregnancy information reading module (2) outputs a pregnancy test result signal at the clinical pregnancy test node indicating a successful pregnancy. The sealing instruction is configured to instruct all of the patient's frozen embryos to be transferred to the sealing storage area (10). The dynamic decision and response module (3) is further configured to generate a long-term storage instruction when the pregnancy information reading module (2) outputs a pregnancy test result signal at the live birth detection node indicating a successful live birth. The long-term storage instruction is configured to instruct all frozen embryos in the sealed storage area (10) to be transferred to the standby liquid nitrogen tank (11).

10. A computer-readable storage medium having a computer program stored thereon, characterized in that, When the computer program is executed by the processor, it implements the embryo sample management method based on dynamic adjustment of pregnancy process as described in any one of claims 1-5.

Images