Antimicrobial cleaning composition

Abstract

The present invention provides an antimicrobial cleaning composition comprising: 0.1 to 2 wt% of β-hydroxy acid, 0.01 to 5 wt% of α-hydroxy acid, 0.001 to 2 wt% of hydroxystearic acid, and 7 to 25 wt% of non-soap surfactant; wherein the pH of the composition is in the range of 5 to 6.

Description

Technical Field

[0001] This invention relates to mild antimicrobial cleansing compositions, and more particularly to personal cleansing compositions. The invention relates to the field of antimicrobial liquid cleansing compositions that are gentle and mild on the skin. Background Technology

[0002] Personal care compositions are formulated for specific purposes, such as antimicrobial action and exfoliation to gentle and mild cleansing.

[0003] Acne, also known as acne vulgaris, is a common skin condition that affects almost every adolescent and adult at some point in their lives. It has a complex etiology involving abnormal keratinization, excessive sebum production, androgen function, bacterial growth, and immune hypersensitivity. Other factors associated with acne include the presence of free radicals and subsequent oxidative stress that leads to cell damage.

[0004] The earliest acne lesions are called microcomedones. These evolve into comedones, which can be open ("blackheads") or closed ("whiteheads"). The various stages of acne are classified as comedones, papules, pustules, and cysts.

[0005] Acne is typically observed to occur in areas rich in sebaceous glands, such as the face, neck, and back. The anaerobic Gram-positive bacterium *Propionibacterium acnes* (…) Propionibacterium acnes ()( P. acnes It was recently renamed Propionibacterium acnes (…). Cutibacterium acnes ()( C. acnes Propionibacterium acnes is also involved in the development of acne. It resides in the sebaceous glands. Propionibacterium acnes uses sebum and byproducts from the surrounding skin tissue as a source of energy and nutrients, thus causing acne or acne vulgaris.

[0006] Many products are marketed for the treatment of acne, including oral pills and topical ointments (e.g., gels and creams). Anti-acne agents such as salicylic acid are commonly known for topical application; however, it is also known that salicylic acid is difficult to formulate, especially in water-based products. Topical application is popular with consumers; however, continued and repeated use of such products can lead to dry and irritated skin, often caused by the anti-acne agents themselves. Therefore, the benefits of topical delivery of anti-acne agents (such as salicylic acid) that are gentle on the skin remain in demand.

[0007] Typically, mild cleaning compositions have a pH close to or less than 7. Even if such compositions are alkaline, their pH is usually below 8. This is because strongly alkaline detergents, such as traditional soap bars and soap-containing liquid detergents, are generally considered caustic. On the other hand, conventional non-soap surfactant-based cleaning compositions with a pH of about 5 to 7 are generally considered mild and gentle, and therefore these surfactants form the matrix of many such compositions.

[0008] US6162774A discloses a skin cleansing composition intended for topical application to moistened skin, comprising an α-hydroxy acid active ingredient formulated in a mild and non-irritating detergent matrix composed of a mixture of nonionic alkyl polyglucosinolate surfactants and amphoteric surfactants. The invention contains 0.2 to 5% salicylic acid in a pH range of 3 to 4.5, which is below the skin's pH value. Summary of the Invention

[0009] According to a first aspect, the present invention provides an antimicrobial cleaning composition comprising: a. 0.1 to 2% by weight of β-hydroxy acids, b. 0.01 to 5% by weight of α-hydroxy acids, c. 0.001 to 2% by weight of hydroxystearic acid, d. 7 to 25% by weight of non-soap surfactants; and The pH of the composition is in the range of 5 to 6.

[0010] A second aspect of the invention provides the use of 0.1 to 2 wt% of a β-hydroxy acid containing salicylic acid, 0.01 to 5 wt% of an α-hydroxy acid containing citric acid, and 0.001 to 2 wt% of hydroxystearic acid in an antimicrobial cleaning composition containing 7 to 25 wt% of a non-soap surfactant, which provides antimicrobial efficacy compared to similar compositions that do not contain salicylic acid, α-hydroxy acids containing citric acid, and hydroxystearic acid, wherein the pH of the composition is in the range of 5 to 6.

[0011] A third aspect of the invention provides the use of a non-therapeutic method for controlling, reducing, or inhibiting Propionibacterium acnes or dermatophytes of the skin, the method comprising the step of applying a composition according to the first aspect to a desired skin surface.

[0012] Another aspect of the invention provides the use of a non-therapeutic method for controlling, reducing, or inhibiting acne on the skin, the method comprising the step of applying a composition according to the first aspect to a desired skin surface.

[0013] Another aspect of the invention provides a packaged personal care / personal laundry product comprising: a container or bottle containing a label or advertisement intended for sale or distribution to a consumer; and an antimicrobial cleaning composition according to the first aspect of the invention.

[0014] These and other aspects, features, and advantages will become apparent to those skilled in the art from the following detailed description and appended claims. For the avoidance of doubt, any feature of one aspect of the invention may be used in any other aspect of the invention.

[0015] The term "comprising" does not imply limitation to any element subsequently stated, but rather encompasses unspecified elements of primary or secondary functional importance. In other words, the listed steps, elements, or options need not be exhaustive. Whenever the terms "comprising" or "having" are used, these terms mean equivalent to "comprising" as defined above. It should be noted that the examples given in the following description are intended to illustrate the invention and are not intended to limit the invention to these examples alone. Similarly, unless otherwise stated, all percentages are by weight / weight percentage.

[0016] Except as expressly stated in the operational and comparative examples or elsewhere, all figures in this specification and claims indicating the amount or reaction conditions of the material, the physical properties of the material, and / or its use should be understood to be modified by the word “about”.

[0017] Numerical ranges expressed in the format "x to y" are understood to include both x and y. When multiple preferred ranges are described in the format "x to y" for a particular feature, it should be understood that combinations of all ranges with different endpoints can also be considered.

[0018] It should be noted that when specifying any concentration or amount range, any particular upper limit concentration can be associated with any particular lower limit concentration or amount.

[0019] As used in this article, skin includes the skin on the face, neck, chest, back, arms (including armpits), armpits, buttocks, hands, legs, and scalp.

[0020] As used herein, acne refers to acne lesions such as microcomedones, open comedones (“blackheads”), closed comedones (“whiteheads”), papules, pustules, and cysts. Treatment, prevention, control, and / or reduction of acne can refer to the appearance and / or reduction of the appearance of acne lesions on the skin surface (e.g., size, lesion type, and / or color) and / or reduction of the number of acne lesions on the skin. As used herein, “anti-acne benefits” can refer to killing bacteria known to cause acne, reducing the number of acne lesions, reducing the appearance of acne lesions on the skin, removing excess oil from the skin, promoting the growth of new skin cells, and / or removing dead skin cells.

[0021] To gain a more complete understanding of the above and other features and advantages of the present invention, reference should be made to the following detailed description of preferred embodiments. Detailed Implementation

[0022] This invention relates to aqueous skin cleansing compositions suitable for topical application to clean the human body (such as skin and hair). In particular, the invention provides a mild antimicrobial cleansing composition that provides a moisturizing after-feel on the skin.

[0023] The present invention provides an antimicrobial cleaning composition comprising 0.1 to 2 wt% of β-hydroxy acid, 0.01 to 5 wt% of α-hydroxy acid, 0.001 to 2 wt% of hydroxystearic acid, and 7 to 25 wt% of non-soap surfactant, wherein the pH of the composition is in the range of 5 to 6.

[0024] The inventors faced the challenge of developing a gentle skin cleansing composition that exhibits good antimicrobial activity while remaining gentle on the skin. To this end, they faced multiple challenges in formulating a gentle, non-drying formulation at a skin-friendly pH while achieving high antimicrobial efficacy against acne-causing bacteria.

[0025] The inventors aimed to develop a mild cleanser with excellent antimicrobial properties against acne-causing bacteria within a skin-friendly pH range of 5.5 ± 0.5. During experimentation, the inventors unexpectedly discovered that when the ingredients of the invention according to the first aspect were combined at specified concentration levels, a mild cleansing composition with synergistic antimicrobial efficacy was obtained. A surprising finding for the inventors was that the synergistic combination of three to four times lower concentrations of β-hydroxy acids (such as salicylic acid) in the liquid cleanser with α-hydroxy acids (such as citric acid) and hydroxystearic acid in the composition, at a skin-friendly pH, provided superior anti-acne efficacy compared to similar formulations without citric acid and 12-hydroxystearic acid.

[0026] The optimal pH for human skin is between 4.7 and 5.75. Pure water has a pH of 7, which is considered neutral. Any pH below this value is acidic, and any pH above this value is alkaline; therefore, the skin's natural pH is slightly acidic. This slightly acidic pH is caused by the skin's acidic outer membrane. The skin's most important function is to act as a protective barrier between the body and the external world. This acidic outer membrane acts as a protective barrier by neutralizing alkaline invaders. It also inhibits bacterial growth and restores and maintains the optimal acidic environment so that the skin's natural flora can thrive. Cleansers with a skin-appropriate pH help retain the skin's natural moisture.

[0027] Salicylic acid is a key anti-acne ingredient; however, it presents a range of problems and cannot be used at high concentrations because it can cause skin irritation and dryness, especially for sensitive, acne-prone, and inflamed skin. Therefore, even though high concentrations of salicylic acid would be useful and more effective in providing antimicrobial benefits, it is practically unusable. Even with higher concentrations of salicylic acid, the adverse effects of these high concentrations need to be offset by other skincare adjuvants and even higher concentrations of pH adjusters, which can again affect the composition's antimicrobial efficacy. Thus, even though some commercially available products may claim to have higher concentrations of salicylic acid and be gentler, in reality, the skincare adjuvants and pH adjusters used to counteract the adverse effects of higher concentrations are compromised in the process of making them gentler. When added, pH adjusters often place the composition in a neutral pH range, rather than a skin-friendly one. The pH adjusters used are often alkalis to balance the low pH of the acid used to control acne (such as salicylic acid), and these alkalis are also detrimental to the skin. The inventors of this invention have obtained a composition with excellent antimicrobial efficacy of up to 99.999% bactericidal effect at concentrations as low as 0.5% by weight of salicylic acid. This antimicrobial efficacy is even better than commercially available products using 2% by weight of salicylic acid. Surprisingly and unexpectedly, such low concentrations of salicylic acid are highly effective when used in combination with α-hydroxy acids and hydroxystearic acid at concentrations according to the first aspect. When using higher concentrations of salicylic acid, the choice of surfactant system is also limited, as only milder surfactants, such as non-sulfate-based surfactants, can be selected. Foaming in cleaning compositions is a known consumer preference, and foaming is significantly affected when the cleaning composition is non-sulfate-based. In the compositions of this invention, the inventors have been able to successfully use sulfate-based surfactants while maintaining the mildness of the composition within a skin-friendly pH range of 5 to 6.

[0028] Antimicrobial cleansing agents with a synergistic combination of β-hydroxy acids, α-hydroxy acids, and hydroxystearic acid have been clinically proven to reduce skin discomfort and redness, reduce acne, and effectively control and remove excess oil within 72 days.

[0029] In consumer testing, consumers reported that their skin felt clean and clear, smooth, soft and supple, and had a better radiance.

[0030] Antimicrobial cleaning composition The present invention provides an antimicrobial cleaning composition comprising 0.1 to 2 wt% of β-hydroxy acid, 0.01 to 5 wt% of α-hydroxy acid, 0.001 to 2 wt% of hydroxystearic acid, 7 to 25 wt% of non-soap surfactant and 0.01 to 1 wt% of pH adjuster; wherein the pH of the composition is in the range of 5 to 6.

[0031] Personal care products are typically marketed based on how gentle they are on the user's skin. Unfortunately, many commonly used surfactants tend to bind to skin proteins, which can cause irritation. Furthermore, different surfactants bind to skin proteins to varying degrees. Therefore, it is preferable to use cleansers that do not leave surfactant residue on the skin.

[0032] The purpose of the zein test is to study the irritation potential (causticity) of any cleansing composition that typically contains surfactants. Zein is a yellow corn protein similar to keratin and is found in skin and hair. Zein is denatured (dissolved) by irritating products (e.g., surfactant products diluted in a specific amount of water). The more zein dissolved in the solution, the higher the predicted irritation potential. Conversely, milder compositions cause less zein dissolution. The zein test provides a rapid and convenient screening for irritation potential, especially for compositions containing surfactants. The zein value (also known as the Zein value) is a fairly standard parameter used in the cosmetics industry.

[0033] The present invention provides an antimicrobial cleansing composition having a skin-friendly pH in the range of 5 to 6, which is typically difficult to achieve while balancing the acidity of the active ingredients in the composition (such as β-hydroxy acids, α-hydroxy acids, and hydroxystearic acid).

[0034] The compositions of the present invention are mild and gentle on the skin, wherein the zein score is in the range of 15 to 35.

[0035] The compositions of the present invention are suitable for use as cleaning compositions, more particularly as personal cleaning compositions, and preferably as personal cleaning compositions for use on the skin.

[0036] Preferably, in the composition of the present invention, the β-hydroxy acid is selected from salicylic acid, β-hydroxybutyric acid, tropinoic acid, trasocolic acid, and combinations thereof.

[0037] Preferably, in the composition of the present invention, the β-hydroxy acid comprises at least 80% by weight of salicylic acid based on the total weight of β-hydroxy acids, and preferably the β-hydroxy acid is salicylic acid.

[0038] Preferably, in the composition of the present invention, the α-hydroxy acid is selected from citric acid, glycolic acid, lactic acid, malic acid, tartaric acid, and combinations thereof.

[0039] Preferably, in the composition of the present invention, the α-hydroxy acid comprises at least 80% by weight of citric acid based on the total weight of the α-hydroxy acid, and preferably the α-hydroxy acid is citric acid.

[0040] Preferably, in the compositions of the present invention, the hydroxystearic acid is 10-hydroxystearic acid or 12-hydroxystearic acid, or a combination thereof.

[0041] Preferably, in the composition of the present invention, the composition contains a pH adjuster in the range of 0.01 to 1% by weight, wherein the pH adjuster is a salt.

[0042] Preferably, the composition of the present invention contains 0.01 to 3% by weight of a chelating agent.

[0043] Preferably, in the compositions of the present invention, the chelating agent is selected from ethylenediaminetetraacetic acid (EDTA) or diethylenetriaminepentaacetic acid (DTPA) and mixtures thereof.

[0044] Preferably, in the composition of the present invention, the composition contains a preservative in the range of 0.01 to 3% by weight of the cleaning composition.

[0045] Preferably, in the compositions of the present invention, the preservative is benzoic acid or a derivative thereof, p-hydroxybenzoic acid ester derivative or sorbic acid derivative, or a mixture or combination thereof.

[0046] Preferably, in the composition of the present invention, the preservative is selected from sodium benzoate, benzoic acid, potassium sorbate, methylparaben, ethylparaben, propylparaben, butylparaben, and heptylparaben, or combinations thereof.

[0047] Preferably, in the compositions of the present invention, the non-soap surfactant is selected from anionic surfactants, amphoteric surfactants, amphoteric surfactants, nonionic surfactants, and mixtures thereof.

[0048] Hydroxystearic acid The compositions of the present invention comprise hydroxystearic acid. Hydroxystearic acid is a C18 chain fatty acid containing one or more OH groups along a hydrocarbon chain. Preferably, the hydroxystearic acid is 10-hydroxystearic acid, 12-hydroxystearic acid, or trihydroxystearic acid (e.g., 9,10,13-trihydroxystearic acid) or trihydroxystearin, or a compound that, upon decomposition, produces one or more hydroxystearic acid or hydroxystearate molecules, such as a monoester, diester, or trimer of glycerol with hydroxystearic acid. More preferably, 10-hydroxystearic acid, 12-hydroxystearic acid, and 9,10,13-trihydroxystearic acid are preferred, and most preferably, 12-hydroxystearic acid (12-HSA). 12-HSA has the structure given below: The present invention comprises hydroxystearic acid, more preferably 12-hydroxystearic acid and 10-hydroxystearic acid, and most preferably 12-hydroxystearic acid. Preferably, hydroxystearic acid is present in the liquid cleaning composition of the present invention in a range of 0.001% to 1.8% by weight, more preferably 0.008% to 1.5% by weight, and most preferably 0.005% to 1.2% by weight, based on the weight of the cleaning composition. Even more preferably, hydroxystearic acid is present in a range of less than 1% by weight, more preferably less than 0.8% by weight, based on the weight of the composition of the present invention. Therefore, more preferably, hydroxystearic acid is present in a range of 0.001% to 1% by weight, and most preferably 0.008% to 0.8% by weight, based on the weight of the composition of the present invention.

[0049] α-hydroxy acid This invention comprises α-hydroxy acids or combinations thereof. α-hydroxy acids (AHAs) are naturally occurring organic carboxylic acids, such as glycolic acid (a natural component of sugarcane juice) and lactic acid (found in yogurt and tomato juice). The α-hydroxy acid may be selected from citric acid, glycolic acid, lactic acid, malic acid, tartaric acid, or combinations thereof. Citric acid is the most preferred α-hydroxy acid for this invention.

[0050] Preferably, the α-hydroxy acid in the composition of the present invention is present in the range of 0.01 to 5% by weight based on the weight of the clean composition, more preferably in the range of 0.02 to 3% by weight, and most preferably in the range of 0.05 to 2% by weight, and even more preferably in the range of 0.05 to 1% by weight.

[0051] Preferably, the α-hydroxy acid in the compositions of the present invention comprises at least 80% by weight, preferably at least 85% by weight, more preferably at least 90% by weight, and most preferably at least 95% by weight of citric acid, based on the total α-hydroxy acid content. In a highly preferred aspect, the α-hydroxy acid in the compositions of the present invention is citric acid.

[0052] Preferably, when citric acid is present in the composition of the present invention, it is present in a range of 0.01 to 5% by weight, more preferably 0.02 to 3% by weight, and most preferably 0.05 to 2% by weight, and even more preferably 0.05 to 1% by weight, based on the weight of the cleaning composition.

[0053] β-hydroxy acid This invention comprises β-hydroxy acids or combinations thereof. The β-hydroxy acid may be selected from salicylic acid (or related substances, such as salicylates, sodium salicylate, and willow extract), β-hydroxybutyric acid, tropinoic acid, tricsocaic acid, or combinations thereof. Salicylic acid is the most preferred β-hydroxy acid for this invention.

[0054] Preferably, the β-hydroxy acid in the composition of the present invention is present in a concentration of 0.01 to 2% by weight, more preferably 0.02 to 1.5% by weight, and most preferably 0.03 to 1.2% by weight, even more preferably 0.05 to 1% by weight, based on the weight of the cleaning composition. Preferably, the β-hydroxy acid in the composition of the present invention is present at a concentration of less than 1% by weight. Most preferably, the β-hydroxy acid is present in a concentration of 0.1 to 0.98% by weight, even more preferably 0.1 to 0.95% by weight, and even more preferably 0.1 to 0.90% by weight, based on the weight of the composition. More preferably, the β-hydroxy acid is present in a concentration of 0.1 to 0.8% by weight, based on the weight of the composition.

[0055] Preferably, in the compositions of the present invention, the β-hydroxy acid comprises at least 80% by weight, preferably at least 85% by weight, more preferably at least 90% by weight, and most preferably at least 95% by weight of salicylic acid based on the total β-hydroxy acid. In a highly preferred aspect, the β-hydroxy acid in the compositions of the present invention is salicylic acid.

[0056] Preferably, when salicylic acid is present in the composition of the present invention, it is present in a range of 0.01 to 3% by weight of the cleaning composition, more preferably 0.02 to 2.5% by weight of the cleaning composition, and most preferably 0.05 to 2% by weight, even more preferably 0.05 to 1.5% by weight. Preferably, salicylic acid is present in the composition of the present invention at a concentration of less than 1% by weight. Most preferably, salicylic acid is present in a range of 0.1 to 0.98% by weight of the composition, even more preferably 0.1 to 0.95% by weight, and even more preferably 0.1 to 0.90% by weight. More preferably, salicylic acid is present in a range of 0.1 to 0.8% by weight of the composition.

[0057] Non-soap surfactants Preferably, the cleaning composition comprises 7 to 25% by weight, more preferably 8 to 23% by weight, even more preferably 10 to 22% by weight, and most preferably 11 to 21% by weight of a non-soap surfactant. The compositions of the present invention may contain anionic surfactants, nonionic surfactants, cationic surfactants, or amphoteric surfactants.

[0058] The synthetic anionic detergent active material that can be used in this invention can be an aliphatic sulfonate, such as a primary alkane (e.g., C8-C4). 22 ) sulfonates, primary alkanes (e.g., C8-C 22 disulfonates, C8-C 22 Olefin sulfonates, C8-C 22Hydroxyalkyl sulfonates or alkyl glycerol ether sulfonates (AGS); or aromatic sulfonates, such as alkylbenzene sulfonates. Anionic surfactants can also be alkyl sulfates (e.g., C14). 12 -C 18 Alkyl sulfates or alkyl ether sulfates (including alkyl glycerol ether sulfates). Alkyl ether sulfates include those having the following formula: RO(CH2CH2O) n SO3M Wherein R is an alkyl or alkenyl group having 8 to 18 carbons, preferably 12 to 18 carbons, and the average value of n is greater than 1.0, preferably less than 3; and M is a solubilizing cation, such as sodium, potassium, ammonium, or substituted ammonium. Preferred are ammonium lauryl ether sulfate and sodium lauryl ether sulfate.

[0059] Anionic surfactants can also be alkyl sulfonyl succinates (including mono- and di-alkyl, e.g., C6-C). 22 sulfosuccinates; alkyl and acyl taurates, alkyl and acyl sarcosinates, sulfoacetates, C8-C 22 Alkyl phosphates and phosphates, alkyl phosphate esters and alkoxyalkyl phosphate esters, acyl lactates, C8-C 22 Monoalkyl succinates and maleates, sulfoacetates, alkyl glucosides and acyl hydroxyethyl sulfonates, etc.

[0060] Sulfosuccinates can be monoalkyl sulfosuccinates having the following formula: R 4 O2CCH2CH(SO3M)CO2M; and The following formula is amide-MEA sulfosuccinate: R 4 CONHCH2CH2O2CCH2CH(SO3M)CO2M Where R 4 The range is C8-C 22 Alkyl group, and M is a solubilizing cation.

[0061] Sarcosine salts are usually represented by the following formula: R 1 CON(CH3)CH2CO2M, Where R 1 The range is C8-C 20 Alkyl group and M is a solubilizing cation.

[0062] Taurine salts are usually represented by the following formula: R 2 CONR 3 CH2CH2SO3M Where R 2 The range is C8-C20 Alkyl, R 3 The range is C1-C4 alkyl, and M is a solubilizing cation.

[0063] The cleaning composition of the present invention may contain C8-C 18 Acyl hydroxyethyl sulfonates. These esters are prepared by reaction of an alkali metal hydroxyethyl sulfonate with a mixture of aliphatic carboxylic acids having 6 to 18 carbon atoms and an iodine value less than 20. At least 75% of the mixed carboxylic acids have 12 to 18 carbon atoms, and up to 25% have 6 to 10 carbon atoms.

[0064] Acylhydroxyethyl sulfonate can be an alkoxylated hydroxyethyl sulfonate, as described in U.S. Patent No. 5,393,466 to Ilardi et al., entitled “Fatty Acid Esters of Polyalkoxylated Isethonic Acid,” issued February 28, 1995; which is incorporated herein by reference. Such compounds have the following general formula: RC-(O)OC(X)HC(Y)H2-(OCH-CH2) m -SO3M + , Where R is an alkyl group having 8 to 18 carbons, m is an integer from 1 to 4, X and Y are hydrogen or alkyl groups having 1 to 4 carbons, and M + It is a monovalent cation, such as sodium, potassium or ammonium.

[0065] The most preferred anionic surfactant used in the compositions of the present invention is selected from sulfonic acids, their salts, alkyl ether sulfates, mixtures and combinations thereof. The most preferred anionic surfactant may include sodium lauryl ether sulfate, its derivatives such as ethylene oxide derivatives, etc.

[0066] Preferably, the cleaning composition comprises an anionic surfactant in the range of 7 to 25% by weight, more preferably in the range of 8 to 23% by weight, even more preferably in the range of 10 to 22% by weight, and most preferably in the range of 11 to 21% by weight.

[0067] Preferably, the cationic surfactant used for the purposes of this invention is, for example, a quaternary ammonium surfactant, including but not limited to: benzalkonium chloride, alkyl betaine, alkylamidopropyl betaine, alkylamidopropyl hydroxysulfonyl betaine alkylamine, alkylimidazolium, and ethoxylated amine. Preferably, the cleaning composition contains 7 to 25% by weight of the composition, more preferably 8 to 23% by weight, further more preferably 10 to 22% by weight, and most preferably 11 to 21% by weight of the cationic surfactant.

[0068] Preferably, the amphoteric surfactant used for the purposes of this invention is, for example, an acyl / dialkylethylenediamine, such as sodium acylamphoacetate, cocamidopropyl betaine (CAPB), disodium acylamphodipropionate, disodium alkylamphodiacetate, sodium acylamphohydroxypropyl sulfonate, disodium acylamphodiacetate and sodium acylamphodipropionate, or an N-alkyl amino acid, such as aminopropylalkylglutamine, alkylaminopropionic acid, sodium alkylimide dipropionate and lauroylamphocarboxyglycinate. Preferably, the cleaning composition contains 7 to 25% by weight, more preferably 8 to 23% by weight, further more preferably 10 to 22% by weight, and most preferably 11 to 21% by weight of the amphoteric surfactant.

[0069] Preferably, the composition comprises a combination of anionic synthetic surfactant and amphoteric surfactant (e.g., betaine), especially when the anionic surfactant accounts for 50% or more of such synthetic surfactant mixture.

[0070] One or more nonionic surfactants can be used as co-surfactants in the cleaning compositions of the present invention. The nonionic surfactants are preferably used at levels as low as 5%, 7.5%, or 10% by weight and as high as 20%, 25%, or 30% by weight. Nonionic surfactants that can be used particularly include the reaction products of compounds having hydrophobic groups and reactive hydrogen atoms (e.g., aliphatic alcohols, acids, amides, or alkylphenols) with epoxides (especially ethylene oxide alone or with propylene oxide). Specific nonionic detergent compounds are alkyl (C6-C4) compounds. 22 ) Phenolic ethylene oxide condensate, aliphatic (C8-C) 18 These are products obtained by the condensation of straight-chain or branched primary or secondary alcohols with ethylene oxide, as well as products obtained by the condensation of ethylene oxide with the reaction products of propylene oxide and ethylenediamine. Other so-called nonionic detergent compounds include long-chain tertiary amine oxides, long-chain tertiary phosphine oxides, and dialkyl sulfoxides.

[0071] Preferred nonionic surfactants include alkyl polyglucosides and carboxylic acid / alcohol ethoxylates having the following structures: a) HOCH2(CH2) n (CH2CH2O) x H or b) HOOC(CH2) m (CH2CH2O) y H; Where m and n are independently <18; and x and y are independently >1; preferably m and n are independently 6 to 18; and x and y are independently 1 to 30; c) HOOC(CH2) i -CH=CH-(CH2) k (CH2CH2O) z H; Where i and k are independently 5 to 15; and z is independently 5 to 50; preferably i and k are independently 6 to 12; and z is independently 15 to 35.

[0072] Nonionic surfactants may also include glycoamides, such as polysaccharide amides. Specifically, the surfactant may be one of the lactosamides described in U.S. Patent No. 5,389,279, entitled "Compositions Comprising Nonionic Glycolipid Surfactants," issued February 14, 1995, by Au et al.; or may be one of the glycoamides described in U.S. Patent No. 5,009,814, entitled "Use of N-Poly HydroxyalkylFatty Acid Amides as Thickening Agents for Liquid Aqueous Surfactant Systems," issued April 23, 1991, by Kelkenberg; which is incorporated herein by reference.

[0073] Preferably, the nonionic surfactant used for the purposes of this invention is, for example, an alkanolamide such as cocamide MEADEA / MIPA, esters produced by esterification of carboxylic acids with ethylene oxide, glycerol, sorbitan or other alcohols and esters, such as ethoxylated alcohols, ethoxylated lanolin, ethoxylated polysiloxanes, propoxylated POE ethers, and alkyl polyglycosides such as lauryl glucoside, decyl glucoside, and cocoyl glucoside. Preferably, the cleaning composition contains 7 to 25% by weight, more preferably 8 to 23% by weight, further more preferably 10 to 22% by weight, and most preferably 11 to 21% by weight of a nonionic surfactant.

[0074] Suitable surfactants that can be used in the formulations disclosed herein may include one or more of sodium cocoyl hydroxyethyl sulfonate, sodium lauryl sulfate, disodium lauryl sulfosuccinate, lauryl glucoside, myristyl glucoside, decyl glucoside, sodium sulfate, sodium silicate, cocamidopropyl betaine, sodium cocoyl sulfate, and sodium dodecyl sulfate. In one embodiment, the surfactant may include sodium cocoyl hydroxyethyl sulfonate. In another embodiment, the surfactant may include disodium dodecyl sulfosuccinate. In a further embodiment, the surfactant may include a mixture of dodecyl glucoside, myristyl glucoside, sodium sulfate, sodium silicate, and sodium cocoyl sulfate. In yet another embodiment, the surfactant may include sodium lauryl sulfate. Suitable surfactants are not limited to those listed herein, but may include other surfactants that are in powder form and water-soluble prior to their incorporation into the formulation to maximize the cleaning potential of the formulation.

[0075] Most preferably, the compositions of the present invention comprise a non-soap surfactant selected from anionic, nonionic, and amphoteric surfactants or mixtures thereof.

[0076] Chelating agents The cleaning composition of the present invention preferably contains a chelating agent. Preferably, the chelating agent in the cleaning composition is present in the range of 0.01 to 3% by weight of the cleaning composition, more preferably in the range of 0.02 to 2.5% by weight of the cleaning composition, and most preferably in the range of 0.05 to 1.5% by weight of the cleaning composition.

[0077] Preferably, the chelating agent in the cleaning composition is present at a weight of at least 0.01% by weight, more preferably at least 0.02% by weight, and most preferably at least 0.05% by weight.

[0078] Preferably, the chelating agent in the cleaning composition is present at a concentration of up to 3% by weight, more preferably up to 2.5% by weight, further preferably up to 2% by weight, and most preferably up to 1.5% by weight.

[0079] Preferred chelating agents are as follows (the abbreviations are in parentheses after the names): Ethylenediaminetetraacetic acid (EDTA), disodium ethylenediaminetetraacetic acid, diethylenetriaminepentaacetic acid (DTPA), ethane-1-hydroxy-1,1-diphosphonic acid (EHDP), ethylenediamine-N,N′-disuccinic acid (EDDS), nitrotriacetic acid (NTA), sodium iminodisuccinate (IDS), ethylene glycol-bis-(2-aminoethyl)-N,N,N′,N′-tetraacetic acid (EGTA), methylglycine diacetic acid (MGDA), N-(2-hydroxyethyl)ethylenediamine-N,N,N′-triacetic acid (HEDTA) Ethylenediaminetetramethylenephosphonic acid (EDTMP), diethylenetriaminepentamethylenephosphonic acid (DTPMP), glutamic acid-N,N-diacetic acid (GLDA), cyclohexane-1,2-diamine-N,N′,N′,N'-tetraacetic acid (CDTA), 1,3-propanediaminetetraacetic acid (PDTA), ethylenediaminetriacetic acid (EDTA), L-hydroxyiminodisuccinic acid (L-IDS), trisodium N-carboxyethyliminosuccinate (CEIS), citric acid, sodium tripolyphosphate (STP), and triethylenetetraminehexaacetic acid (TTHA). Other preferred chelating agents are trisodium ethylenediaminedisuccinate, tetrasodium iminodisuccinate, tetrasodium glutamic acid-N,N-diacetic acid, sodium 2-hydroxyethyliminodisuccinate (disodium ethanol diglycine), tetrasodium 3-hydroxy-2,2-iminodisuccinate, trisodium methylglycine diacetate, and tetrasodium L-aspartic acid-N,N-diacetic acid. More preferred chelating agents are salts of ethylenediaminetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA). Preferred EDTA salts are disodium ethylenediaminetetraacetic acid and tetrasodium ethylenediaminetetraacetic acid. Preferred DTPA salts are pentasodium diethylenetriaminepentaacetic acid.

[0080] Most preferably, the chelating agent suitable for the compositions of the present invention is selected from ethylenediaminetetraacetic acid (EDTA), or diethylenetriaminepentaacetic acid (DTPA), its derivatives and combinations thereof, or mixtures thereof. EDTA derivatives are selected from tetrasodium EDTA, trisodium EDTA, disodium EDTA, and combinations thereof. DTPA derivatives are selected from tetrasodium DTPA, trisodium DTPA, disodium DTPA, and combinations thereof.

[0081] preservative The cleaning composition of the present invention preferably contains a preservative. Preferably, the preservative in the cleaning composition is present in the range of 0.01 to 3% by weight of the cleaning composition, more preferably in the range of 0.02 to 2% by weight of the cleaning composition, and most preferably in the range of 0.05 to 1% by weight of the cleaning composition.

[0082] Examples of very useful preservatives suitable for the compositions of the present invention include, but are not limited to, chlorite components, benzoic acid components, sorbic acid components, and mixtures thereof.

[0083] Other preferred preservatives include, but are not limited to, those commonly used in cosmetics, such as dibromo-2-bromomethylglutaronitrile (2-bromo-2-bromomethylglutaronitrile), phenoxyethanol, 3-iodo-2-propynyl butylcarbamate, 2-bromo-2-nitro-propane-1,3-diol, imidazolidinyl urea (hamstoff), 5-chloro-2-methyl-4-isothiazolin-3-one, 2-chloroacetamide, benzalkonium chloride, sodium benzoate, and benzyl alcohol.

[0084] According to the present invention, sodium benzoate, sodium salicylate, methyldibromoglutaronitrile, phenoxyethanol, and combinations thereof are particularly preferred as preservatives.

[0085] water The cleaning composition of the present invention comprises water in the range of 60 to 90% by weight, more preferably 65 to 85% by weight, and most preferably 68 to 80% by weight, based on the weight of the composition. The composition of the present invention is primarily an aqueous composition.

[0086] pH Preferably, the pH range of the composition of the present invention is 5 to 7, more preferably 5 to 6.

[0087] The pH of the solution is expressed as the negative logarithm of the hydrogen ion activity, which is related to the millivolt potential of the pH indicator electrode. The electrode is calibrated using a standard buffer mixture whose pH value falls on either side of the pH of the solution being measured (acidic or alkaline). Weigh approximately 1 gram of the cleaning composition into a beaker and add distilled water at 25°C to make 100 grams. Measure the pH value.

[0088] pH adjuster The compositions of the present invention preferably contain a pH adjuster. When a pH adjuster is present in the compositions of the present invention, it is present in a range of 0.01 to 1% by weight, preferably 0.05 to 0.8% by weight, more preferably 0.08 to 0.7% by weight, and most preferably 0.09 to 0.6% by weight, based on the weight of the compositions of the present invention.

[0089] pH adjusters are components responsible for adjusting the existing pH of the composition.

[0090] Select a pH adjuster to maintain the pH of the composition in the range of 5 to 7, more preferably 5 to 6, and most preferably 5.0 to 5.75.

[0091] Preferably, the pH adjuster is a salt, and the pH of the composition is adjusted in a way that increases the pH. The pH adjuster is preferably a skin-safe or cosmetic-grade salt. The pH adjuster may be sodium bicarbonate, potassium carbonate, calcium hydroxide, potassium hydroxide, potassium bicarbonate, sodium hydroxide, or a combination thereof. In various embodiments, the pH adjuster is sodium bicarbonate.

[0092] For the purposes of this invention, the pH adjuster does not include β-hydroxy acids, α-hydroxy acids, and hydroxystearic acid as described in the first aspect.

[0093] Moisturizer The term "emollient" is defined as a substance that softens or improves the elasticity, appearance, and youthfulness of the skin (stratum corneum) by increasing its water content, adding or replacing lipids and other skin nutrients, or both, and by maintaining its softness by slowing down the decrease in its water content.

[0094] Moisturizers (which are also humectants), such as polyhydroxy alcohols, for example glycerol and propylene glycol; and polyols, such as polyethylene glycol, such as Polyox WSR N-60K (PEG-45M), are used in preferred embodiments of the invention. The humectants are preferably used in amounts of at least 0.5% by weight, 2.5% by weight, or 5% by weight, and at most 15% by weight, 20% by weight, or 25% by weight.

[0095] Hydrophobic emollients are used in preferred embodiments of the invention. Preferably, they are hydrophobic emollients having a weight-average particle size of less than 1000 or 500 micrometers in diameter, and are defined herein as “finely dispersed oils.” These emollients are preferably used at a minimum of 0.5%, 2.5%, or 5% by weight and a maximum of 15%, 20%, or 25% by weight.

[0096] Suitable hydrophobic emollients include, but are not limited to, the following: (a) Silicone oils and their modifiers, such as linear and cyclic polydimethylsiloxanes; amino, alkyl, alkylaryl and aryl silicone oils; (b) Fats and oils, including natural fats and oils (triglycerides), such as jojoba oil, soybean oil, sunflower oil, rice bran oil, avocado oil, almond oil, olive oil, sesame oil, peach kernel oil, castor oil, coconut oil, mink oil; cocoa butter; beef tallow, lard; hardened oils obtained by hydrogenation of the above oils; and synthetic monoglycerides, diglycerides and triglycerides, such as glyceryl myristate and glyceryl 2-ethylhexanoate; (c) Waxes, such as carnauba wax, cetacean wax, beeswax, lanolin and their derivatives; (d) Hydrophobic plant extracts; (e) Hydrocarbons, such as petrolatum, polybutene, liquid paraffin, microcrystalline wax, ceresin, squalene, pristan and mineral oil; (f) Higher alcohols, such as lauryl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, behenyl alcohol, cholesterol and 2-hexyldecyl alcohol; (g) Esters, such as cetyl caprylate, myristyl lactate, cetyl lactate, isopropyl myristate, myristyl myristate, isopropyl palmitate, isopropyl adipate, butyl stearate, decyl oleate, cholesterol isostearate, glyceryl monostearate, glyceryl distearate, glyceryl tristearate, alkyl lactate, alkyl citrate, and alkyl tartrate; (h) Essential oils and their extracts, such as peppermint, jasmine, camphor, white cedarwood, bitter orange peel, willow, turpentine, cinnamon, bergamot, Satsuma mandarin, calamus, pine, lavender, bay leaf, clove, cypress, eucalyptus, lemon, starflower, thyme, peppermint, rose, sage, sesame, ginger, basil, juniper, lemongrass, rosemary, rosewood, avocado, grape, grape seed, myrrh, cucumber, watercress, calendula, elderflower, geranium, linden flower, amaranth, seaweed, ginkgo, ginseng, carrot, guarana, tea tree, jojoba, comfrey, oats, cocoa, orange blossom, vanilla, green tea, pennywort. Royal), aloe vera, menthol, eugenol, citral, citronelle, borneol, linalool, geraniol, evening primrose, camphor, thymol, spirantol, pentene, limonene, and terpene oils; (i) Mixtures of any of the above components, etc.

[0097] Beneficial agents In addition to the ingredients described above, preferred embodiments of the cleaning composition may also include other optional and preferred ingredients due to their known benefits. The type and amount depend largely on the nature and type of the cleaning composition and the general principles of formulation science.

[0098] Other optional components include one or more skin-beneficial agents. The term "skin-beneficial agent" is defined as a substance that softens or improves the elasticity, appearance, and youthful appearance of the skin (stratum corneum) by increasing its water content, adding or replacing lipids and other skin nutrients, or both; and by maintaining its softness by slowing down the decrease in its water content. Suitable skin-beneficial agents include emollients, including, for example, hydrophobic emollients, hydrophilic emollients, or blends thereof. Water-soluble skin-beneficial agents may optionally be formulated into the liquid compositions of the present invention. Various water-soluble skin-beneficial agents may be used and in amounts ranging from 0 to 50% by weight of the composition, but preferably from 1 to 30% by weight. These materials include, but are not limited to, polyhydroxy alcohols. Preferred water-soluble skin-beneficial agents are glycerin, sorbitol, and polyethylene glycol.

[0099] Water-insoluble skin-beneficial agents can also be formulated into compositions as conditioning and moisturizing agents. Examples include silicone oils; hydrocarbons such as liquid paraffin, petrolatum, microcrystalline wax, and mineral oils; and vegetable triglycerides such as sunflower seed oil and cottonseed oil.

[0100] Preservatives may also be added to the composition to prevent the growth of potentially harmful microorganisms. Suitable conventional preservatives for use in the compositions of the present invention are alkyl esters of hydrobenzoic acid. Other preservatives that have recently come into use include caprolactone derivatives, propionates, and various quaternary ammonium compounds. Particularly preferred preservatives are phenoxyethanol, methylparaben, propylparaben, imidazolidinyl urea, sodium dehydroacetate, and benzyl alcohol. The selection of preservatives should take into account the intended use of the composition and possible incompatibilities between the preservative and other components. Preservatives are preferably used in amounts ranging from 0.01% to 2% by weight of the composition.

[0101] A variety of other optional materials can be formulated into the composition. These may include: antimicrobial agents; scrubs and exfoliating particles, such as polyethylene with silica or alumina; cooling agents, such as menthol; skin soothing agents, such as aloe vera; and colorants.

[0102] Shower gels or washes may contain particles with an average diameter of approximately 50 μm, which help remove dry skin. Without being bound by theory, the degree of exfoliation depends on the size and morphology of the particles. Large, coarse particles are often very harsh and irritating. Very small particles may not be effective exfoliants. Such exfoliants used in the art include natural minerals such as silica, talc, calcite, pumice, tricalcium phosphate; seeds such as rice, apricot kernels, etc.; ground shells such as almond and walnut shells; oats; polymers such as polyethylene glycol and polypropylene glycol beads; petals and leaves; microcrystalline wax beads; jojoba ester beads, etc. These exfoliants exhibit a wide variety of particle sizes and morphologies, ranging from micrometers to millimeters. They also have a range of hardness. Some examples are talc, calcite, pumice, walnut shells, dolomite, and polyethylene.

[0103] Advantageously, active agents other than the skin conditioning agents defined above may also be incorporated into the composition. These active ingredients may advantageously include antibacterial agents, vitamins, anti-acne active substances; anti-wrinkle, anti-skin atrophy, and skin repair active substances; skin barrier repair active substances; non-steroidal cosmetic soothing active substances; artificial tanning agents and accelerators; skin whitening active substances; sunscreen active substances; sebum stimulants; sebum inhibitors; antioxidants; protease inhibitors; skin firming agents; antipruritic ingredients; hair growth inhibitors; 5-α reductase inhibitors; desquamating enzyme enhancers; anti-glycation agents; or mixtures thereof; etc.

[0104] These active agents may be selected from water-soluble active agents, oil-soluble active agents, pharmaceutically acceptable salts, and mixtures thereof. As used herein, the term "active agent" means a personal care active substance that may be used to deliver benefits to the skin and / or hair, and is generally not used to impart skin conditioning benefits delivered via emollients as defined above. As used herein, the term "safe and effective amount" means an amount of active agent that is high enough to alter the condition being treated or to deliver the desired skin care benefit, but low enough to avoid serious side effects. As used herein, the term "benefit" means a therapeutic, preventative, and / or long-term benefit associated with treating a particular condition using one or more of the active agents described herein. The safe and effective amount of an active agent will vary depending on the specific active agent, the ability of the active substance to penetrate the skin, the user's age, health condition, and skin condition, and other similar factors.

[0105] A wide variety of active ingredients can be used in the compositions of the present invention, including those selected from anti-acne active substances, anti-wrinkle and anti-skin atrophy active substances, skin barrier repair aids, cosmetic soothing aids, local anesthetics, artificial tanning agents and accelerators, skin whitening active substances, antimicrobial and antifungal active substances, sunscreen active substances, sebum stimulants, sebum inhibitors, anti-glycation active substances, and mixtures thereof.

[0106] Anti-acne active substances can effectively treat acne vulgaris, a chronic condition of sebaceous gland follicles. Non-limiting examples of useful anti-acne active substances include keratolytic agents such as salicylic acid (o-hydroxybenzoic acid), derivatives of salicylic acid such as 5-octanoyl salicylic acid and 4-methoxysalicylic acid, and resorcinol; retinoids such as retinoic acid and its derivatives (e.g., cis and trans); sulfur-containing D- and L-amino acids and their derivatives and salts, especially their N-acetyl derivatives, mixtures thereof, etc.

[0107] Skin barrier repair active substances are skin care active ingredients that help repair and replenish the natural moisture barrier function of the epidermis. Non-limiting examples of skin barrier repair active substances include lipids such as cholesterol, ceramides, sucrose esters and pseudoceramides, as described in European Patent Specification No. 556957; ascorbic acid; biotin; biotin esters; phospholipids, mixtures thereof, etc.

[0108] Artificial tanning agents can help mimic natural tanning by increasing melanin in the skin or by creating the appearance of increased melanin production. Non-limiting examples of artificial tanning agents and accelerators include dihydroxyacetone; tyrosine; tyrosine esters such as ethyl tyrosine ester and glucosyl tyrosine ester; mixtures thereof, etc.

[0109] Skin-whitening active ingredients can actually reduce the amount of melanin in the skin or provide such effects through other mechanisms. Non-limiting examples of useful skin-whitening active ingredients include aloe vera extract, α-glycero-L-ascorbic acid, aminotyrosine, ammonium lactate, glycolic acid, hydroquinone, 4-hydroxyanisole; mixtures thereof, etc.

[0110] Sunscreen active ingredients are also useful. Non-limiting examples of sunscreen agents useful in the compositions of the present invention are those selected from octyl methoxycinnamate (Parsol MCX) and butyl methoxybenzoylmethane (Parsol 1789), 2-ethylhexyl p-methoxycinnamate, 2-ethylhexyl N,N-dimethyl-p-aminobenzoate, p-aminobenzoic acid, 2-phenylbenzimidazole-5-sulfonic acid, oxybenzone, mixtures thereof, etc.

[0111] Protease inhibitors are also useful. Protease inhibitors can be divided into two main classes: proteases and peptidases. Proteases act on specific internal peptide bonds of proteins, while peptidases act on peptide bonds adjacent to the free amino or carboxyl groups at the protein's ends, thus cleaving the protein from the outside. Protease inhibitors suitable for cleaning compositions include, but are not limited to, proteases such as serine proteases, metalloproteinases, cysteine ​​proteases, and aspartic proteases, and peptidases such as carboxypeptidases, dipeptidases, and aminopeptidases, mixtures thereof, etc.

[0112] Other useful active ingredients are skin tightening agents. Non-limiting examples of skin tightening agents that can be used in the compositions of the present invention include monomers such as (meth)acrylic acid that can bind polymers to the skin, and hydrophobic monomers composed of long-chain alkyl (meth)acrylates, mixtures thereof, etc.

[0113] The active ingredients in the cleaning composition may also include antipruritic ingredients. Suitable examples of antipruritic ingredients that can be used in the compositions of the present invention include hydrocortisone, methdilizine, and trimeprazine, mixtures thereof, etc.

[0114] Non-limiting examples of hair growth inhibitors that can be used in the personal toilet soap bar compositions of the present invention include 17-β-estradiol, anti-angiogenic steroids, turmeric extract, cyclooxygenase inhibitors, evening primrose oil, linoleic acid, etc. Suitable 5-α-reductase inhibitors, such as ethinylestradiol, genistine, and mixtures thereof, etc.

[0115] Advantageously, the cationic skin feeler or polymer is used in amounts of about 0.01% by weight, 0.1% by weight or 0.2% by weight to about 1% by weight, 1.5% by weight or 2.0% by weight.

[0116] Cationic cellulose can be polymerized in the Polymer JR® and LR® series from Amerchol Corp. (Edison, NJ, USA), such as salts of hydroxyethyl cellulose reacted with trimethylammonium-substituted epoxides, known industrially (CTFA) as Polyquaternium® 10. Another type of cationic cellulose includes polymerized quaternary ammonium salts of hydroxyethyl cellulose reacted with lauryl dimethylammonium-substituted epoxides, known industrially (CTFA) as Polyquaternium® 24. These materials are also available under the trade name Polymer LM-200® from Amerchol Corp. (Edison, NJ, USA), as well as quaternary ammonium compounds such as alkyl dimethyl ammonium halides.

[0117] Particularly suitable types of cationic polysaccharide polymers that can be used are cationic guar gum derivatives, such as guar hydroxypropyltrimethylammonium chloride (commercially available from Rhone-Poulenc under the JAGUAR® brand). Examples include JAGUAR® C13S, which has a low degree of cationic substitution and high viscosity; JAGUAR® C15, which has a moderate degree of substitution and low viscosity; JAGUAR® C17 (high degree of substitution, high viscosity); JAGUAR® C16, which is a hydroxypropylated cationic guar gum derivative containing low levels of substituent groups and cationic quaternary ammonium groups; and JAGUAR® 162, which is a high-transparency, medium-viscosity guar gum with a low degree of substitution.

[0118] Particularly preferred cationic polymers are JAGUAR® C13S, JAGUAR® C15, JAGUAR® C17, JAGUAR® C16, and JAGUAR® C162, especially JAGUAR® C13S. Other cationic skin-feeling agents known in the art may be used, provided they are compatible with the formulations of the present invention.

[0119] Other preferred cationic compounds that can be used in this invention include amide quaternary ammonium compounds, such as quaternary ammonium propionates and lactates, as well as quaternary ammonium hydrolysates of silk or wheat proteins. Many of these compounds are available from McIntyre Group Ltd. (University Park, Ill.) as Mackine® aminofunctional amines, Mackalene® aminofunctional tertiary amine salts, and Mackpro® cationic protein hydrolysates.

[0120] In embodiments containing a hydrolyzed protein conditioner, the average molecular weight of the hydrolyzed protein is preferably about 2500. Preferably, 90% of the hydrolyzed protein has a molecular weight between about 1500 and about 3500. In a preferred embodiment, MACKPRO® WWP (i.e., wheat germ dimethylamine hydrolyzed wheat protein) is added to the composition at a concentration of 0.1% (as is).

[0121] Antimicrobial efficacy Antimicrobial efficacy can be evaluated using a procedure similar to that described in ASTM International Test Method ASTM E2783-22: Standard test method for assessment of antimicrobial activity for water miscible compounds using time-kill procedure: accredited by ENAC (Spanish National Accreditation Entity) (which is incorporated herein by reference). This test method measures changes in aerobic and anaerobic microbial populations over a specific sampling time when testing antimicrobial test materials in vitro. The organisms used are standardized for growth requirements and inoculum preparation and must be grown under the test conditions. The primary objective of this test method is to provide a standardized set of conditions and test organisms to facilitate comparative evaluation of miscible antimicrobial materials in aqueous systems. For testing, a diluted / amplified sample of the test material is exposed to a known population of the test organism at a specified temperature for a specified time period. The activity of the test material is quenched using appropriate neutralization and quenching techniques at specified sampling intervals (e.g., 15, 30, and 60 seconds, or any range covering minutes or hours). The test material is neutralized at the sampling time, and the surviving microorganisms are counted. Calculate the percentage reduction relative to the initial microbial population and log10.

[0122] use The present invention provides the use of a β-hydroxy acid containing salicylic acid, an α-hydroxy acid containing citric acid, and a hydroxy fatty acid according to the first aspect for providing antimicrobial efficacy compared with similar compositions that do not contain a β-hydroxy acid containing salicylic acid, an α-hydroxy acid containing citric acid, and a hydroxy fatty acid.

[0123] The present invention provides the use of a β-hydroxy acid containing salicylic acid, an α-hydroxy acid containing citric acid, and a hydroxy fatty acid according to the first aspect for providing a mild antimicrobial composition with a zein value in the range of 15 to 35 compared with similar compositions that do not contain a β-hydroxy acid containing salicylic acid, an α-hydroxy acid containing citric acid, and a hydroxy fatty acid.

[0124] The present invention provides the use of a β-hydroxy acid containing salicylic acid, an α-hydroxy acid containing citric acid, and a hydroxy fatty acid according to the first aspect for providing an anti-acne effect compared with similar compositions that do not contain a β-hydroxy acid containing salicylic acid, an α-hydroxy acid containing citric acid, and a hydroxy fatty acid.

[0125] The present invention provides the use of a β-hydroxy acid containing salicylic acid, an α-hydroxy acid containing citric acid, and a hydroxy fatty acid according to the first aspect for controlling, inhibiting, or reducing the growth of Propionibacterium acnes (a bacterium that produces acne) compared to similar compositions that do not contain a β-hydroxy acid containing salicylic acid, an α-hydroxy acid containing citric acid, and a hydroxy fatty acid.

[0126] The present invention provides the use of 0.1 to 2 wt% of a β-hydroxy acid containing salicylic acid, 0.01 to 5 wt% of an α-hydroxy acid containing citric acid, and 0.001 to 2 wt% of a hydroxy fatty acid in an antimicrobial cleaning composition containing 7 to 25 wt% of a non-soap surfactant, which provides antimicrobial efficacy compared to similar compositions that do not contain salicylic acid, contain an α-hydroxy acid containing citric acid, and contain a hydroxy fatty acid, wherein the pH of the composition is in the range of 5 to 6.

[0127] The present invention provides the use of a non-therapeutic method for controlling, reducing or inhibiting Propionibacterium acnes or dermatophytes acnes on the skin, the method comprising the step of applying a composition according to the first aspect to a desired skin surface.

[0128] method The cleaning composition of the present invention is prepared using a method comprising the following steps: a. Dissolve α-hydroxy acids, β-hydroxy acids, and hydroxy fatty acids in an aqueous medium at a temperature of approximately 70-80°C, followed by the addition of a non-soap surfactant. b. Add moisturizers (such as glycerin), colorants, preservatives, fragrances, and other skin-beneficial adjuvants to obtain the antimicrobial cleansing composition of the first aspect.

[0129] Preferably, in the method of the present invention, the chelating agent is dissolved in an aqueous medium, followed by the partial addition of sodium lauryl ether sulfate. After uniform dispersion, 12-hydroxystearic acid and salicylic acid are added at 70-80°C with stirring until dissolved, followed by the further addition of the remaining anionic surfactant until completely dissolved. The mixture is then cooled, and decyl glucoside and glycerin are added. Preferably, the preservatives, colorants, fragrances, and other skin-beneficial adjuvants are added after the addition of the non-soap surfactant.

[0130] This invention provides a method for controlling, reducing, or inhibiting the growth of Propionibacterium acnes compared to similar compositions that do not contain β-hydroxy acids, α-hydroxy acids, and hydroxy fatty acids.

[0131] This invention provides a method for controlling, reducing, or inhibiting the growth of Propionibacterium acnes on the skin, the method comprising the step of applying the composition of the first aspect to a desired skin surface. Preferably, the composition is rinsed off after application.

[0132] While the invention has been described with reference to specific embodiments thereof, it will be apparent to those skilled in the art that many other forms and modifications of the invention will be readily apparent. The appended claims and the invention itself should generally be construed as covering all such obvious forms and modifications that fall within the true spirit and scope of the invention.

[0133] Example The invention will now be illustrated by means of embodiments. These embodiments are for illustrative purposes only and do not limit the scope of the claims in any way.

[0134] Example 1 Preparation of formulation The chelating agent was dissolved in an aqueous medium, followed by partial addition of sodium lauryl ether sulfate. After uniform dispersion, 12-hydroxy fatty acid and salicylic acid were added at 70-80°C with stirring until dissolved. The remaining anionic surfactant was then added until completely dissolved. The mixture was then cooled, followed by the addition of decyl glucoside and glycerin. Preservatives, colorants, fragrances, and other skin-beneficial additives were then added.

[0135] Compositions P1 to P5 were prepared according to the above method and compared with each other and with a control in terms of antimicrobial activity and mildness.

[0136] Compositions P1 and P2 were prepared according to the present invention. The control composition is free of hydroxystearic acid, β-hydroxy acid, and α-hydroxy acid. P3 is free of α-hydroxy acid, P4 is free of β-hydroxy acid, and P5 is free of hydroxystearic acid.

[0137] Antimicrobial efficacy bacteria The bacterial reduction efficacy of the liquid detergent was evaluated based on test method: ASTM E2783-22. The organism used was *Propionibacterium acnes* ATCC 6919, the test temperature was 25℃±1℃, the contact time was 30 seconds, and the sample concentration was 50%. The incubation conditions were anaerobic at 35℃±2℃ for 5 days. The test was performed in triplicate.

[0138] The antimicrobial efficacy of the compositions in Table 1 was evaluated using a procedure similar to that described in ASTM E2783-22: Standard test method for assessment of antimicrobial activity for watermiscible compounds using time-kill procedure: accredited by ENAC (Spanish National Accreditation Entity) (the entire contents of which are incorporated herein by reference).

[0139] This testing method measures changes in aerobic and anaerobic microbial populations over a specific sampling period when testing antimicrobial test materials in vitro. The organisms used are standardized regarding growth requirements and inoculum preparation, and must be grown under the test conditions. The primary objective of this method is to provide a standardized set of conditions and test organisms to facilitate comparative evaluation of miscible antimicrobial materials in aqueous systems.

[0140] To conduct the test, at a specified temperature, a diluted / amplified sample of the test material is exposed to a known number of test organisms for a specified period of time. The activity of the test material is quenched using appropriate neutralization and quenching techniques at specified sampling intervals (e.g., 15, 30, and 60 seconds, or any range covering minutes or hours). The test material is neutralized at the sampling time, and the surviving microorganisms are counted. The percentage reduction relative to the initial microbial population and log10 are calculated.

[0141] The log reduction in each challenge suspension attributable to the test solution for each timed exposure is calculated for each replicate as follows: Log10 decrease = Log10 average (NC) - Log10 average (Pex); Where NC = control population CFU / ml, Pex = post-exposure population CFU / ml average log 10 reduce: >1 log = 90%, >2 log = 99%, >3 log = 99.9%, >4 log = 99.99%, and 5 log or >5 log = 99.999%. A mean log reduction of 5 or higher in the formulation indicates 99.999% antimicrobial efficacy against Propionibacterium acnes (the bacteria that causes acne).

[0142] Mildness assessment The skin mildness of the liquid compositions, controls, and P1 to P2 compositions prepared according to the present invention, as shown in Table 1, was evaluated using the zein solubility assay. 0.3 g of zein powder (Sigma. 23625-1 kg, lot number # SLBZ2926 or Acros Organic™ Zein) was added to 10 ml of a 5% dilution of the test formulation and mixed for 30 minutes at room temperature. After 30 minutes, the resulting sample was visually inspected to determine the presence of excess undissolved zein. If no excess zein was found, an additional 0.3 g of zein was added and mixed for another 30 minutes. The resulting sample was then filtered using a 0.45 μm filter. The filtrate was diluted in 2% sodium dodecyl sulfate solution, and the absorbance at 298 nm was measured to determine the amount of dissolved zein. A control experiment was prepared in a similar manner using liquid compositions depleted of zein, and background was measured at 298 nm. The amount of dissolved zein is reported as follows: Zein absorbance = [Absorbance of zein in the liquid composition (298 nm) - Absorbance of the background sample (298 nm)] Dilution factor. Milder products dissolve less zein and give lower absorbance values. Table A shows the range of zein values ​​for mildness of different cleaning compositions.

[0143] Table A

[0144] Table 1

[0145] The data in Table 1 clearly show that the control compositions, which do not contain any hydroxystearic acid, β-hydroxy acid, or α-hydroxy acid, exhibit a specific antimicrobial activity with an average log-kill of 1.14. When β-hydroxy acid and α-hydroxy acid are present (e.g., in P5), the average log-kill increases to 1.56; it further increases in the presence of α-hydroxy acid and hydroxystearic acid (e.g., in P4), where the average log-kill is 1.68. When hydroxystearic acid and β-hydroxy acid are combined (e.g., in P3), the average log-kill shows a significant improvement. However, when all three components—β-hydroxy acid, α-hydroxy acid, and hydroxystearic acid—are combined (e.g., in P1 and P2), with the remaining components of the composition remaining constant, the combination of the three components demonstrates a significant synergistic effect and an unexpected improvement in antimicrobial efficacy, as described by the synergistic increase in average log-kill. Furthermore, compositions P1 and P2 according to the invention even have a good zein score of approximately 25, indicating that despite their good antimicrobial efficacy, they remain gentle and mild on the skin. It is equally evident that even a lower concentration (0.5 wt%) of salicylic acid in composition P1 of the present invention provides excellent antimicrobial efficacy comparable to that in P2, which contains a higher concentration (2 wt%) of salicylic acid.

[0146] Composition P6 has a higher concentration of α-hydroxy acid, while P7 has a lower concentration. Composition P6 is not suitable for use within the desired pH range, while composition P7 exhibits an antimicrobial efficacy of no more than 90%. Composition P8 has a higher concentration of hydroxystearic acid, while P9 has a lower concentration. Composition P8 exhibits an antimicrobial efficacy of no more than 90%, while composition P9 is unstable under storage conditions, and precipitation was observed.

Claims

1. An antimicrobial cleaning composition comprising: a. 0.1 to 2% by weight of β-hydroxy acids, b. 0.01 to 5% by weight of α-hydroxy acids, c. 0.001 to 2% by weight of hydroxystearic acid, d. 7 to 25% by weight of non-soap surfactants; and The pH of the composition is in the range of 5 to 6.

2. The composition according to claim 1, wherein the β-hydroxy acid is selected from salicylic acid, β-hydroxybutyric acid, tropinoic acid, trasocolic acid, and combinations thereof.

3. The composition according to claim 1 or 2, wherein the β-hydroxy acid comprises at least 80% by weight of salicylic acid based on the total weight of β-hydroxy acids.

4. The composition according to any one of claims 1 to 3, wherein the α-hydroxy acid is selected from citric acid, glycolic acid, lactic acid, malic acid, tartaric acid, and combinations thereof.

5. The composition according to any one of claims 1 to 4, wherein the α-hydroxy acid comprises at least 80% by weight of citric acid based on the total weight of the α-hydroxy acid.

6. The composition according to any one of claims 1 to 5, wherein the hydroxystearic acid is 10-hydroxystearic acid or 12-hydroxystearic acid, or a combination thereof.

7. The composition according to any one of claims 1 to 6, wherein the composition comprises a pH adjuster in the range of 0.01 to 1% by weight.

8. The composition according to claim 7, wherein the pH adjuster is a salt.

9. The composition according to any one of claims 1 to 8, wherein the composition comprises 0.01 to 3% by weight of a chelating agent.

10. The composition according to claim 9, wherein the chelating agent is selected from ethylenediaminetetraacetic acid (EDTA) or diethylenetriaminepentaacetic acid (DTPA) and mixtures thereof.

11. The composition according to any one of claims 1 to 10, wherein the composition comprises a preservative in the range of 0.01 to 3% by weight of the cleaning composition.

12. The composition according to claim 11, wherein the preservative is selected from sodium benzoate, benzoic acid, potassium sorbate, methylparaben, ethylparaben, propylparaben, butylparaben, and heptylparaben, or combinations thereof.

13. The composition according to any one of claims 1 to 12, wherein the non-soap surfactant is selected from anionic surfactants, amphoteric surfactants, amphoteric surfactants, nonionic surfactants, and mixtures thereof.

14. Use of 0.1 to 2% by weight of a β-hydroxy acid containing salicylic acid, 0.01 to 5% by weight of an α-hydroxy acid containing citric acid, and 0.001 to 2% by weight of hydroxystearic acid in an antimicrobial cleaning composition containing 7 to 25% by weight of a non-soap surfactant to provide antimicrobial efficacy compared to an antimicrobial cleaning composition not containing salicylic acid, an α-hydroxy acid containing citric acid, and hydroxystearic acid, wherein the pH of said composition is in the range of 5 to 6.

15. A non-therapeutic method for controlling, reducing or inhibiting Propionibacterium acnes or dermatophytes acnes on the skin, the method comprising the step of applying a composition according to any one of claims 1 to 13 to a desired skin surface.

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