A dietary supplement composition for promoting metabolic repair and a method of preparing the same

Abstract

The application discloses a dietary supplement composition for promoting metabolic repair and a preparation method thereof, and relates to the technical field of functional food, and comprises the following components in parts by weight: broccoli seed extract microcapsules 50-200 parts, and alcohol extract of Chinese jujube seed 80-250 parts; wherein the broccoli seed extract microcapsules are microparticles formed by embedding water extract or alcohol extract of broccoli seeds with beta-cyclodextrin or sodium octenyl succinate starch as wall materials; the dietary supplement composition for promoting metabolic repair and the preparation method thereof have the advantages that the broccoli seed extract is prepared into microcapsules with beta-cyclodextrin or sodium octenyl succinate starch as wall materials, and the content of sulforaphane in the microcapsules is controlled to be 2-8 wt%, so that the active ingredients in the broccoli seeds are effectively isolated and protected in the processing and storage processes, and can resist the action of the gastric acid environment and enzymes after oral administration, and the premature degradation of necrotic proteins is reduced.

Description

Technical Field

[0001] This invention relates to the field of functional food technology, specifically to a dietary supplement composition that promotes metabolic repair and its preparation method. Background Technology

[0002] Metabolic repair is a key physiological process by which the body, after suffering damage from oxidative stress, exogenous toxins, or metabolic disorders, rebuilds cellular metabolic homeostasis and tissue function by activating endogenous antioxidant responses, promoting the expression of phase II detoxification enzymes, and regulating the autophagy-lysosomal pathway. In recent years, functional foods with Nrf2 pathway agonists derived from natural products as core components have received considerable attention in the field of metabolic repair. Broccoli seeds are rich in glucosinolates, and their endogenous myrosinase hydrolysis product, sulforaphane, is one of the most effective natural Nrf2 activators known to date. It can upregulate the expression of various cell protection genes and shows clear activity in antioxidation, liver protection, and mitochondrial function maintenance. However, the isothiocyanate group (-N=C=S) in the sulforaphane molecule is highly electrophilic and extremely sensitive to heat, oxygen, and acid-base environments. Especially under the acidic conditions of the human stomach (pH 1.5–3.5) and the action of pepsin, it is easily hydrolyzed or isomerized, leading to a significant reduction in its oral bioavailability. To improve the stability of sulforaphane, existing technologies have attempted to use microencapsulation techniques to protect it, such as preparing microcapsules using gelatin, gum arabic, or modified starch as wall materials, in order to isolate it from the external environment and achieve targeted delivery.

[0003] However, existing microencapsulation methods still have significant shortcomings in practical oral applications. Although microcapsule wall materials can delay the release of active ingredients to some extent, most conventional wall materials (such as gelatin and gum arabic) swell or disintegrate under acidic gastric conditions. The sulforaphane encapsulated in these materials is exposed to the gastric juice environment before reaching the absorption site in the small intestine, resulting in a considerable proportion of sulforaphane being prematurely degraded in the stomach and unable to effectively exert its biological function. Although some studies have attempted to use enteric coating materials to resist gastric acid, such materials often require high coating thickness or complex preparation processes, and may affect the rapid release of active ingredients in the intestine, thereby affecting absorption efficiency. Furthermore, existing technologies lack systematic optimization and control over the loading of sulforaphane in microcapsules. Low loading results in insufficient active ingredient per unit dose, while excessively high loading may weaken the protective effect due to insufficient wall material ratio, making the protective effect of microcapsules unstable in the gastric environment. Therefore, improvements are needed. Summary of the Invention

[0004] The purpose of this invention is to provide a dietary supplement composition that promotes metabolic repair and its preparation method, in order to solve the problem in the prior art that microencapsulated broccoli seed extract is difficult to effectively resist the acidic environment and enzymatic hydrolysis of the stomach after oral administration, leading to premature degradation of sulforaphane.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a dietary supplement composition for promoting metabolic repair, comprising the following components in parts by weight:

[0006] Broccoli seed extract microcapsules 50-200 parts, Hovenia dulcis ethanol extract 80-250 parts;

[0007] The broccoli seed extract microcapsules are formed by encapsulating water or alcohol extracts of broccoli seeds with β-cyclodextrin or sodium octenyl succinate starch as the wall material. The content of sulforaphane in the microcapsules is 2% to 8% by weight.

[0008] Furthermore, the ethanol extract of Hovenia dulcis is a powder obtained by reflux extraction of Hovenia dulcis seeds with an aqueous ethanol solution of 55%–80% by volume, followed by vacuum concentration and drying.

[0009] Furthermore, the preparation process of the broccoli seed extract microcapsules includes: pulverizing broccoli seeds, extracting them with water or an aqueous solution of 30% to 60% ethanol at 25°C to 50°C, concentrating the extract, mixing it with an aqueous solution of wall material, homogenizing it, and spray drying it to obtain the microcapsules.

[0010] Furthermore, the composition is in the form of tablets, capsules, granules or oral liquid, and contains pharmaceutically or food-grade excipients.

[0011] A method for preparing a dietary supplement composition that promotes metabolic repair includes the following steps:

[0012] S1. Crush broccoli seeds and extract them 1 to 3 times with an extraction solvent at 25℃~50℃. Combine the extracts and concentrate them under reduced pressure to a concentration with a relative density of 1.05~1.15. Mix the concentration with a wall material aqueous solution with a mass fraction of 10%~30% at a volume ratio of 1:3~1:8. After homogenization, granulate by spray drying to obtain broccoli seed extract microcapsule powder.

[0013] S2. Crush the Japanese raisin tree fruit, add 55% to 80% ethanol aqueous solution, reflux extract at 70℃ to 85℃ 1 to 3 times, combine the extracts, concentrate under reduced pressure and vacuum dry or spray dry to obtain Japanese raisin tree fruit ethanol extract powder.

[0014] S3. Weigh the broccoli seed extract microcapsule powder obtained in step S1 and the Japanese raisin tree extract powder obtained in step S2 according to the weight parts mentioned above, and mix them evenly in a mixer to obtain the liver-protecting composition.

[0015] Further, in step S1, the extraction solvent is pure water or an aqueous solution of ethanol with a volume fraction of 40%, and the wall material is an aqueous solution of β-cyclodextrin with a mass fraction of 15% to 25%.

[0016] Furthermore, in step S2, the volume fraction of the ethanol-water solution is 65%–75%, and the reflux extraction time is 1.5–2.5 hours.

[0017] Furthermore, in step S3, a flow aid or lubricant, accounting for no more than 5% of the total weight of the composition, is added. The flow aid is silica, and the lubricant is magnesium stearate. The mixture is then mixed, tableted, or filled into capsules.

[0018] Compared with the prior art, the present invention provides a dietary supplement composition for promoting metabolic repair and its preparation method. By preparing broccoli seed extract into microcapsules using β-cyclodextrin or sodium octenyl succinate starch as the wall material, and controlling the content of sulforaphane in the microcapsules to 2% to 8% by weight, the active ingredients in broccoli seeds are effectively isolated and protected during processing and storage. This allows them to resist the acidic environment and enzyme action of the stomach after oral administration, reducing the premature degradation of necrotic proteins.

[0019] By combining the broccoli seed extract microcapsules encapsulated in the aforementioned specific wall material with the Hovenia dulcis alcohol extract in the stated weight proportions, a stable and physically isolated homogeneous system is formed in the solid state. This avoids the adsorption or reaction between the active ingredients of broccoli seeds and the polyphenols in Hovenia dulcis due to direct contact, thereby maintaining the composition stability and appearance consistency of the composition during long-term storage. Attached Figure Description

[0020] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in this invention. For those skilled in the art, other drawings can be obtained based on these drawings.

[0021] Figure 1 The preparation process flowchart is provided for an embodiment of the present invention. Detailed Implementation

[0022] To enable those skilled in the art to better understand the technical solution of the present invention, the present invention will be further described in detail below with reference to the accompanying drawings.

[0023] As attached Figure 1 As shown:

[0024] Example 1:

[0025] This invention provides a method for preparing a dietary supplement composition that promotes metabolic repair, comprising the following steps:

[0026] S1. Preparation of broccoli seed extract microcapsules:

[0027] Take 1.0 kg of dried broccoli seeds, crush them using a grinder, and pass them through a 40-mesh sieve. Add the resulting powder to an extraction tank, add 8.0 L of pure water, stir and heat to 40°C, and extract at 40°C with stirring for 2.0 hours. After extraction, filter through a 200-mesh filter cloth and collect the filtrate. Return the filter residue to the extraction tank, add another 6.0 L of pure water, and continue extraction at 40°C with stirring for 1.5 hours, filtering in the same manner. Combine the two filtrates and concentrate under reduced pressure in a rotary evaporator at 55°C and -0.08 MPa to a relative density of 1.08 (measured at 60°C) to obtain the concentrated solution.

[0028] Separately, 250g of β-cyclodextrin was added to 1.2L of pure water, stirred, and heated to 50℃ to completely dissolve it. After cooling to room temperature, a wall material aqueous solution with a mass fraction of approximately 17% was obtained. The aforementioned concentrated solution and the wall material aqueous solution were mixed at a volume ratio of 1:5 and homogenized using a high-speed homogenizer at 10,000 rpm for 20 minutes to obtain a homogeneous emulsion. The emulsion was dried using a spray dryer under the following conditions: inlet air temperature 185℃, outlet air temperature 92℃, and feed rate controlled at 25mL / min. The dried powder was collected and passed through an 80-mesh sieve to obtain broccoli seed extract microcapsule powder. High-performance liquid chromatography (HPLC) analysis showed that the sulforaphane content in the microcapsules was 5.2% (by weight).

[0029] S2. Preparation of Hovenia dulcis ethanol extract:

[0030] Take 1.0 kg of dried Hovenia dulcis seeds, crush them, and pass them through a 20-mesh sieve. Place the powder in an extraction tank, add 10.0 L of 70% (v / v) ethanol aqueous solution, stir, and heat to 80°C. Reflux and extract at 80°C for 2.0 hours. Filter the hot extract through a 200-mesh filter cloth and collect the filtrate. Return the residue to the extraction tank, add another 8.0 L of 70% (v / v) ethanol aqueous solution, and reflux and extract at 80°C for 1.5 hours. Filter using the same method. Combine the two filtrates and concentrate under reduced pressure in a rotary evaporator at 60°C and -0.08 MPa to obtain an extract with a relative density of 1.12 (measured at 60°C). Place the obtained extract in a vacuum drying oven and dry at 65°C and -0.08 MPa for 24 hours. After drying, crush and pass the extract through an 80-mesh sieve to obtain the Hovenia dulcis ethanol extract powder.

[0031] S3. Preparation of the liver-protecting composition:

[0032] Weigh each component according to the following parts by weight:

[0033] 60 parts by weight of broccoli seed extract microcapsule powder obtained in step S1;

[0034] 100 parts by weight of the Hovenia dulcis ethanol extract powder obtained in step S2;

[0035] The two powders were weighed and put into a three-dimensional motion mixer. The speed was set to 20 rpm and the mixture was mixed for 30 minutes until the powder color was uniform. The mixture was then discharged to obtain the liver-protecting composition.

[0036] The resulting liver-protective composition is a uniform powder ranging from light brown to yellowish-brown. It can be used directly as a raw material for dietary supplements or filled into hard capsule shells to produce capsules. For filling, size 0 hard capsules are used, with each capsule containing 350mg ± 5% of the total volume. The resulting capsules are then ready.

[0037] Example 2:

[0038] This invention provides a method for preparing a dietary supplement composition that promotes metabolic repair, comprising the following steps:

[0039] S1. Preparation of broccoli seed extract microcapsules:

[0040] Take 1.0 kg of dried broccoli seeds, crush them using a grinder, and pass them through a 40-mesh sieve. Add the resulting powder to an extraction tank, add 8.0 L of pure water, stir and heat to 40°C, and extract at 40°C with stirring for 2.0 hours. After extraction, filter through a 200-mesh filter cloth and collect the filtrate. Return the filter residue to the extraction tank, add another 6.0 L of pure water, and continue extraction at 40°C with stirring for 1.5 hours, filtering in the same manner. Combine the two filtrates and concentrate under reduced pressure in a rotary evaporator at 55°C and -0.08 MPa to a relative density of 1.08 (measured at 60°C) to obtain the concentrated solution.

[0041] Separately, 250g of β-cyclodextrin was added to 1.2L of pure water, stirred, and heated to 50℃ to completely dissolve it. After cooling to room temperature, a wall material aqueous solution with a mass fraction of approximately 17% was obtained. The aforementioned concentrated solution and the wall material aqueous solution were mixed at a volume ratio of 1:5 and homogenized using a high-speed homogenizer at 10,000 rpm for 20 minutes to obtain a homogeneous emulsion. The emulsion was dried using a spray dryer under the following conditions: inlet air temperature 185℃, outlet air temperature 92℃, and feed rate controlled at 25mL / min. The dried powder was collected and passed through an 80-mesh sieve to obtain broccoli seed extract microcapsule powder. High-performance liquid chromatography (HPLC) analysis showed that the sulforaphane content in the microcapsules was 5.2% (by weight).

[0042] S2. Preparation of Hovenia dulcis ethanol extract:

[0043] Take 1.0 kg of dried Hovenia dulcis seeds, crush them, and pass them through a 20-mesh sieve. Place the powder in an extraction tank, add 10.0 L of 70% (v / v) ethanol aqueous solution, stir, and heat to 80°C. Reflux and extract at 80°C for 2.0 hours. Filter the hot extract through a 200-mesh filter cloth and collect the filtrate. Return the residue to the extraction tank, add another 8.0 L of 70% (v / v) ethanol aqueous solution, and reflux and extract at 80°C for 1.5 hours. Filter using the same method. Combine the two filtrates and concentrate under reduced pressure in a rotary evaporator at 60°C and -0.08 MPa to obtain an extract with a relative density of 1.12 (measured at 60°C). Place the obtained extract in a vacuum drying oven and dry at 65°C and -0.08 MPa for 24 hours. After drying, crush and pass the extract through an 80-mesh sieve to obtain the Hovenia dulcis ethanol extract powder.

[0044] S3. Preparation of the liver-protecting composition:

[0045] Weigh each component according to the following parts by weight:

[0046] 180 parts by weight of broccoli seed extract microcapsule powder obtained in step S1;

[0047] 220 parts by weight of Hovenia dulcis ethanol extract powder obtained in step S2;

[0048] The two powders were weighed and put into a three-dimensional motion mixer. The speed was set to 20 rpm and the mixture was mixed for 30 minutes until the powder color was uniform. The mixture was then discharged to obtain the liver-protecting composition.

[0049] The resulting liver-protecting composition is a uniform powder ranging from light brown to yellowish-brown. It can be packaged into aluminum-plastic composite film strip bags using a granule filling machine, with each bag containing 2.0g ± 3%. The bags are then heat-sealed to obtain the finished granule-form dietary supplement.

[0050] Example 3:

[0051] This invention provides a method for preparing a dietary supplement composition that promotes metabolic repair, comprising the following steps:

[0052] S1. Preparation of broccoli seed extract microcapsules:

[0053] Take 1.0 kg of dried broccoli seeds, crush them using a grinder, and pass them through a 40-mesh sieve. Add the resulting powder to an extraction tank, add 8.0 L of pure water, stir and heat to 40°C, and extract at 40°C with stirring for 2.0 hours. After extraction, filter through a 200-mesh filter cloth and collect the filtrate. Return the filter residue to the extraction tank, add another 6.0 L of pure water, and continue extraction at 40°C with stirring for 1.5 hours, filtering in the same manner. Combine the two filtrates and concentrate under reduced pressure in a rotary evaporator at 55°C and -0.08 MPa to a relative density of 1.08 (measured at 60°C) to obtain the concentrated solution.

[0054] Separately, 250g of β-cyclodextrin was added to 1.2L of pure water, stirred, and heated to 50℃ to completely dissolve it. After cooling to room temperature, a wall material aqueous solution with a mass fraction of approximately 17% was obtained. The aforementioned concentrated solution and the wall material aqueous solution were mixed at a volume ratio of 1:5 and homogenized using a high-speed homogenizer at 10,000 rpm for 20 minutes to obtain a homogeneous emulsion. The emulsion was dried using a spray dryer under the following conditions: inlet air temperature 185℃, outlet air temperature 92℃, and feed rate controlled at 25mL / min. The dried powder was collected and passed through an 80-mesh sieve to obtain broccoli seed extract microcapsule powder. High-performance liquid chromatography (HPLC) analysis showed that the sulforaphane content in the microcapsules was 5.2% (by weight).

[0055] S2. Preparation of Hovenia dulcis ethanol extract:

[0056] Take 1.0 kg of dried Hovenia dulcis seeds, crush them, and pass them through a 20-mesh sieve. Place the powder in an extraction tank, add 10.0 L of 70% (v / v) ethanol aqueous solution, stir, and heat to 80°C. Reflux and extract at 80°C for 2.0 hours. Filter the hot extract through a 200-mesh filter cloth and collect the filtrate. Return the residue to the extraction tank, add another 8.0 L of 70% (v / v) ethanol aqueous solution, and reflux and extract at 80°C for 1.5 hours. Filter using the same method. Combine the two filtrates and concentrate under reduced pressure in a rotary evaporator at 60°C and -0.08 MPa to obtain an extract with a relative density of 1.12 (measured at 60°C). Place the obtained extract in a vacuum drying oven and dry at 65°C and -0.08 MPa for 24 hours. After drying, crush and pass the extract through an 80-mesh sieve to obtain the Hovenia dulcis ethanol extract powder.

[0057] S3. Preparation of the liver-protecting composition powder mixture:

[0058] Weigh each component according to the following parts by weight:

[0059] 180 parts by weight of broccoli seed extract microcapsule powder obtained in step S1;

[0060] 220 parts by weight of Hovenia dulcis ethanol extract powder obtained in step S2;

[0061] The two powders were weighed and put into a three-dimensional motion mixer. The speed was set to 20 rpm and the mixture was mixed for 30 minutes until the powder color was uniform. The mixture was then discharged to obtain the liver-protecting composition powder.

[0062] S4. Preparation of liver-protecting tablets:

[0063] Weigh 850g of the liver-protecting composition powder obtained in step S3, add 120g of microcrystalline cellulose, 20g of croscarmellose sodium, 5g of silicon dioxide, and 5g of magnesium stearate, and put them into a three-dimensional motion mixer. Mix at 20 rpm for 20 minutes to obtain the total mixture. Compress the mixture using a rotary tablet press with a die diameter of 12mm, controlling the tablet weight to 0.8g / tablet ± 5% and the hardness to 6-8kg / cm² to obtain liver-protecting tablets.

[0064] Comparative Example 1:

[0065] S1. Preparation of broccoli seed extract microcapsules (wall material: gelatin):

[0066] Take 1.0 kg of dried broccoli seeds, crush them using a grinder, and pass them through a 40-mesh sieve. Add the resulting powder to an extraction tank, add 8.0 L of pure water, stir and heat to 40°C, and extract at 40°C with stirring for 2.0 hours. After extraction, filter through a 200-mesh filter cloth and collect the filtrate. Return the filter residue to the extraction tank, add another 6.0 L of pure water, and continue extraction at 40°C with stirring for 1.5 hours, filtering in the same manner. Combine the two filtrates and concentrate under reduced pressure in a rotary evaporator at 55°C and -0.08 MPa to a relative density of 1.08 (measured at 60°C) to obtain the concentrated solution.

[0067] Separately, 250g of gelatin was added to 1.2L of pure water and swollen in a 40℃ water bath for 30 minutes. The temperature was then raised to 60℃ and stirred until completely dissolved. After cooling to room temperature, a gelatin wall material aqueous solution with a mass fraction of approximately 17% was obtained. The aforementioned concentrated solution and the gelatin wall material aqueous solution were mixed at a volume ratio of 1:5 and homogenized using a high-speed homogenizer at 10,000 rpm for 20 minutes to obtain a homogeneous emulsion. This emulsion was dried using a spray dryer under the following conditions: inlet air temperature 185℃, outlet air temperature 92℃, and feed rate controlled at 25mL / min. The dried powder was collected and passed through an 80-mesh sieve to obtain broccoli seed extract microcapsule powder with gelatin as the wall material.

[0068] S2. Preparation of Hovenia dulcis ethanol extract:

[0069] Take 1.0 kg of dried Hovenia dulcis seeds, crush them, and pass them through a 20-mesh sieve. Place the powder in an extraction tank, add 10.0 L of 70% (v / v) ethanol aqueous solution, stir, and heat to 80°C. Reflux and extract at 80°C for 2.0 hours. Filter the hot extract through a 200-mesh filter cloth and collect the filtrate. Return the residue to the extraction tank, add another 8.0 L of 70% (v / v) ethanol aqueous solution, and reflux and extract at 80°C for 1.5 hours. Filter using the same method. Combine the two filtrates and concentrate under reduced pressure in a rotary evaporator at 60°C and -0.08 MPa to obtain an extract with a relative density of 1.12 (measured at 60°C). Place the obtained extract in a vacuum drying oven and dry at 65°C and -0.08 MPa for 24 hours. After drying, crush and pass the extract through an 80-mesh sieve to obtain the Hovenia dulcis ethanol extract powder.

[0070] S3. Preparation of the comparative composition:

[0071] Weigh each component according to the following parts by weight:

[0072] 60 parts by weight of broccoli seed extract microcapsule powder with gelatin as the wall material obtained in step S1.

[0073] 100 parts by weight of the Hovenia dulcis ethanol extract powder obtained in step S2;

[0074] The two powders were weighed and put into a three-dimensional motion mixer. The speed was set to 20 rpm and the mixture was mixed for 30 minutes until the powder color was uniform. The mixture was then discharged to obtain the comparison composition.

[0075] The obtained comparative composition was in powder form and filled into No. 0 hard capsules, with each capsule containing 350mg ± 5% of the total volume, thus obtaining the comparative capsule formulation.

[0076] Comparative Example 2:

[0077] S1. Preparation of broccoli seed extract powder (without microencapsulation):

[0078] Take 1.0 kg of dried broccoli seeds, crush them using a grinder, and pass them through a 40-mesh sieve. Add the resulting powder to an extraction tank, add 8.0 L of pure water, stir and heat to 40°C, and extract at 40°C with stirring for 2.0 hours. After extraction, filter through a 200-mesh filter cloth and collect the filtrate. Return the filter residue to the extraction tank, add another 6.0 L of pure water, and continue extraction at 40°C with stirring for 1.5 hours, filtering in the same manner. Combine the two filtrates and concentrate under reduced pressure in a rotary evaporator at 55°C and -0.08 MPa to a relative density of 1.08 (measured at 60°C) to obtain the concentrated solution.

[0079] The obtained concentrate was directly dried using a spray dryer. The spray drying conditions were set as follows: inlet air temperature 185℃, outlet air temperature 92℃, and feed rate controlled at 25mL / min. The dried powder was collected and passed through an 80-mesh sieve to obtain broccoli seed extract powder without microencapsulation treatment.

[0080] S2. Preparation of Hovenia dulcis ethanol extract:

[0081] Take 1.0 kg of dried Hovenia dulcis seeds, crush them, and pass them through a 20-mesh sieve. Place the powder in an extraction tank, add 10.0 L of 70% (v / v) ethanol aqueous solution, stir, and heat to 80°C. Reflux and extract at 80°C for 2.0 hours. Filter the hot extract through a 200-mesh filter cloth and collect the filtrate. Return the residue to the extraction tank, add another 8.0 L of 70% (v / v) ethanol aqueous solution, and reflux and extract at 80°C for 1.5 hours. Filter using the same method. Combine the two filtrates and concentrate under reduced pressure in a rotary evaporator at 60°C and -0.08 MPa to obtain an extract with a relative density of 1.12 (measured at 60°C). Place the obtained extract in a vacuum drying oven and dry at 65°C and -0.08 MPa for 24 hours. After drying, crush and pass the extract through an 80-mesh sieve to obtain the Hovenia dulcis ethanol extract powder.

[0082] S3. Preparation of the comparative composition:

[0083] Weigh each component according to the following parts by weight:

[0084] 60 parts by weight of broccoli seed extract powder without microencapsulation treatment obtained in step S1;

[0085] 100 parts by weight of the Hovenia dulcis ethanol extract powder obtained in step S2;

[0086] The two powders were weighed and put into a three-dimensional motion mixer. The speed was set to 20 rpm and the mixture was mixed for 30 minutes until the powder color was uniform. The mixture was then discharged to obtain the comparison composition.

[0087] The obtained comparative composition was in powder form and filled into No. 0 hard capsules, with each capsule containing 350mg ± 5% of the total volume, thus obtaining the comparative capsule formulation.

[0088] The comparison table is shown below:

[0089]

[0090]

[0091] The foregoing has only described certain exemplary embodiments of the present invention by way of illustration. Undoubtedly, those skilled in the art can modify the described embodiments in various ways without departing from the spirit and scope of the present invention. Therefore, the foregoing drawings and descriptions are illustrative in nature and should not be construed as limiting the scope of protection of the claims of the present invention.

Claims

1. A dietary supplement composition for promoting metabolic repair, characterized in that, It comprises the following components in parts by weight: Broccoli seed extract microcapsules 50-200 parts, Hovenia dulcis ethanol extract 80-250 parts; The broccoli seed extract microcapsules are formed by encapsulating water or alcohol extracts of broccoli seeds with β-cyclodextrin or sodium octenyl succinate starch as the wall material. The content of sulforaphane in the microcapsules is 2% to 8% by weight.

2. The dietary supplement composition for promoting metabolic repair according to claim 1, characterized in that, The ethanol extract of Hovenia dulcis is a powder obtained by reflux extraction of Hovenia dulcis seeds with an aqueous ethanol solution of 55%–80% by volume, followed by vacuum concentration and drying.

3. The dietary supplement composition for promoting metabolic repair according to claim 1, characterized in that, The preparation process of the broccoli seed extract microcapsules includes: crushing broccoli seeds, extracting them with water or a 30%–60% (v / v) ethanol aqueous solution at 25°C–50°C, concentrating the extract, mixing it with a wall material aqueous solution, homogenizing it, and spray drying it to obtain the microcapsules.

4. The dietary supplement composition for promoting metabolic repair according to claim 1, characterized in that, The composition is in the form of tablets, capsules, granules or oral liquid, and contains pharmaceutically or food-acceptable excipients.

5. A method for preparing a dietary supplement composition for promoting metabolic repair, applicable to the dietary supplement composition for promoting metabolic repair as described in any one of claims 1 to 4, characterized in that, Includes the following steps: S1. Crush broccoli seeds and extract them 1 to 3 times with an extraction solvent at 25℃~50℃. Combine the extracts and concentrate them under reduced pressure to a concentration with a relative density of 1.05~1.

15. Mix the concentration with a wall material aqueous solution with a mass fraction of 10%~30% at a volume ratio of 1:3~1:

8. After homogenization, granulate by spray drying to obtain broccoli seed extract microcapsule powder. S2. Crush the Japanese raisin tree fruit, add 55% to 80% ethanol aqueous solution, reflux extract at 70℃ to 85℃ 1 to 3 times, combine the extracts, concentrate under reduced pressure and vacuum dry or spray dry to obtain Japanese raisin tree fruit ethanol extract powder. S3. Weigh the broccoli seed extract microcapsule powder obtained in step S1 and the Japanese raisin tree extract powder obtained in step S2 according to the weight parts mentioned above, and mix them evenly in a mixer to obtain the liver-protecting composition.

6. The method for preparing a dietary supplement composition for promoting metabolic repair according to claim 5, characterized in that, In step S1, the extraction solvent is pure water or an aqueous solution of ethanol with a volume fraction of 40%, and the wall material is an aqueous solution of β-cyclodextrin with a mass fraction of 15% to 25%.

7. The method for preparing a dietary supplement composition for promoting metabolic repair according to claim 5, characterized in that, In step S2, the volume fraction of the ethanol-water solution is 65%–75%, and the reflux extraction time is 1.5–2.5 hours.

8. The method for preparing a dietary supplement composition for promoting metabolic repair according to claim 5, characterized in that, In step S3, a flow aid or lubricant, comprising no more than 5% of the total weight of the composition, is added. The flow aid is silica, and the lubricant is magnesium stearate. The mixture is then mixed, tableted, or filled into capsules.

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