Degradable magnesium metal radiopaque closure clip and method of making

Abstract

The application discloses a degradable magnesium metal developing closure clamp and a preparation method thereof, and relates to the technical field of degradable magnesium metal closure clamps. The degradable magnesium metal developing closure clamp comprises upper clamp arms, a connecting piece and lower clamp arms which are sequentially connected, the connecting piece is provided with a mounting hole, a partition piece is slidably connected to the mounting hole, two sides of the partition piece in the mounting hole are formed into a first sub-hole and a second sub-hole, the first sub-hole is filled with a developing medium, an adjusting mechanism connected to the partition piece is arranged in the second sub-hole, and the adjusting mechanism is used for driving the partition piece to move along the axis direction of the mounting hole; the adjusting mechanism comprises a pipe body connected to the mounting hole, a rotating assembly is threadedly connected to the pipe body, and the rotating assembly is connected to the partition piece. The filling depth of the developing medium can be adjusted.

Description

Technical Field

[0001] This application relates to the technical field of biodegradable magnesium metal closure clips, and in particular to a biodegradable magnesium metal developing closure clip and its preparation method. Background Technology

[0002] Biodegradable magnesium metal clips are often used in surgical laparoscopic and open surgeries to mechanically compress and stop bleeding in blood vessels and soft tissue bundles. Magnesium-based materials have the excellent clamping mechanical properties of metals, and their degradation products can be metabolized and absorbed by the human body. Unlike titanium clips, they do not remain in the body for a long time and cause foreign body inflammation, nor do they interfere with imaging. Therefore, they have significant advantages in clinical application.

[0003] Typically, magnesium metal closure clips are integrally formed from upper and lower clamping arms and a middle connector. To facilitate postoperative imaging positioning, blind holes are often made in the connector area and filled with iodinated biodegradable polymers as imaging media to mark the vascular closure site, which facilitates intraoperative fluoroscopy and postoperative follow-up.

[0004] Most existing blind holes are opened on the front of the connector. The hole body is a straight hole structure with a uniform diameter along the axial direction. Liquid iodinated polymer is directly injected into the hole and naturally solidifies and forms. The size of the blind hole is fixed after the depth processing is completed. The shape and filling amount of the developing medium in the hole after forming are determined by the filling process at one time.

[0005] Designers wanted the filling depth of the contrast medium to be adjustable. Since the geometry of the blind holes is fixed after molding, the filling length of the contrast medium cannot be adjusted after filling and curing, and the filling depth is permanently locked after the product leaves the factory. Different clinical scenarios, such as long-term tumor follow-up and short-term superficial tissue hemostasis, require different contrast ratios and magnesium matrix degradation rates. Specifically, for long-term tumor follow-up, the contrast medium needs to be filled sufficiently deep and have a high iodine content. This requires a large amount of contrast medium to ensure long-term, high-definition tracking of the clamping point, and also to mask the blind holes to slow the degradation rate of the clamp as a whole, especially the connectors. Conversely, for short-term superficial tissue hemostasis, the contrast medium needs to be filled less and shallower, or even none at all. In these scenarios, tissue usually heals completely within a short time without the need for further tracking and marking. For this type of clamp, rapid degradation is required to reduce the time foreign bodies remain in the body. The aforementioned existing technologies cannot meet the needs of various application scenarios. Relying solely on imaging media with a fixed filling depth cannot match the diverse surgical requirements. Multiple types of closure clips can only be produced by opening molds in different specifications, which increases production and storage costs and results in poor clinical adaptability. Summary of the Invention

[0006] In order to allow the filling depth of the developing medium to be adjusted, this application provides a biodegradable magnesium metal developing closure clip and its preparation method.

[0007] The biodegradable magnesium metal developing and closing clip provided in this application adopts the following technical solution: A biodegradable magnesium metal developing clamp includes an upper clamping arm, a connector, and a lower clamping arm connected in sequence. The connector has a mounting hole, and a partition is slidably connected to the mounting hole. A first sub-hole and a second sub-hole are formed on both sides of the partition in the mounting hole. The first sub-hole is filled with developing medium, and an adjustment mechanism connected to the partition is installed in the second sub-hole. The adjustment mechanism is used to drive the partition to move along the axis of the mounting hole. The adjustment mechanism includes a tube connected to the mounting hole, and a rotating assembly is threadedly connected to the tube. The rotating assembly is connected to the partition.

[0008] By adopting the above technical solution, the first sub-hole serves as a storage cavity for the contrast medium, which is filled with solidified contrast medium to achieve postoperative imaging positioning. When the rotating assembly is rotated, the threaded engagement structure converts the rotational motion into linear feed motion along the axis of the mounting hole, stably driving the partition to translate axially along the mounting hole, changing the position of the partition within the mounting hole, and thus changing the effective accommodating space of the first sub-hole, thereby adjusting the effective filling depth of the contrast medium inside the first sub-hole. This structure breaks the limitation of the traditional magnesium clip contrast medium filling depth being fixed at the factory. Relying on only one set of uniformly sized clips, the amount of contrast medium filling can be adjusted by preoperatively translating the partition, simultaneously changing the intensity of the CT contrast signal and the contact area between the magnesium matrix and body fluid. This takes into account differentiated clinical needs such as long-term tumor follow-up and short-term superficial hemostasis, eliminating the need for separate mold production for different specifications, significantly reducing production and storage costs, and enhancing clinical adaptability.

[0009] Preferably, the rotating assembly includes a first rotating column and a second rotating column. The first rotating column is threaded to the pipe body and connected to the partition. The first rotating column has a spline hole at its end. The second rotating column has a spline portion connected to the spline hole. The second rotating column has a twisting portion, and the twisting portion is exposed to the external environment after the second rotating column can slide.

[0010] By adopting the above technical solution, when in use, pulling out the second rotating column exposes the screwing part, and rotating the screwing part can drive the first rotating column to rotate and move through the connection and cooperation between the spline part and the spline hole.

[0011] Preferably, the partition includes a partition head that is slidably attached to the mounting hole and a connecting post connected to the partition head, wherein the connecting post is rotatably connected to the first rotating post.

[0012] By adopting the above technical solution, the partition head is sealed and isolated from the developing medium, the connecting column and the first rotating column can rotate relative to each other, and the first rotating column does not transmit torsional force when it rotates and feeds, which can ensure the reliable movement of the partition head.

[0013] Preferably, the tube body includes multiple annular grooves arranged along the axial direction on the inner sidewall, and the connecting column includes an elastic locking protrusion on the outer sidewall, which can be engaged in any annular groove and emit a prompt sound.

[0014] By adopting the above technical solution, the annular groove inside the tube cooperates with the elastic locking protrusion of the connecting column. When the elastic locking protrusion moves, it generates a gear indication sound, which makes it convenient for medical staff to adjust the imaging depth. At the same time, the annular groove and the elastic locking protrusion can interlock with each other to prevent the partition from sliding on its own inside the tube.

[0015] Preferably, the first rotating column has a snap-fit ​​groove, and the second rotating column has a snap-fit ​​connector; under normal conditions, the snap-fit ​​connector is snapped into the snap-fit ​​groove, and the second rotating column is located in the mounting hole.

[0016] By adopting the above technical solution, the snap-fit ​​connector and the snap-fit ​​groove engage with each other, the second rotating column is normally locked to prevent accidental dislodgement, and the twisting part can only be extended by external force. The structure is flat and safe when stored.

[0017] Preferably, the diameter of the first sub-hole gradually increases along the axial direction of the mounting hole toward the partition member, and the partition member has deformation capability.

[0018] By adopting the above technical solution, the diameter of the first sub-hole gradually expands towards the partition, and the cross-sectional area of ​​the developing medium is different at different positions along the axis of the first sub-hole. During subsequent scanning, the degree of degradation of this application in the human body can be determined based on the developing area.

[0019] Preferably, the end of the upper clamping arm away from the connector is the first end, and the end of the lower clamping arm away from the connector is the second end. Both the first end and the second end have receiving holes, and each receiving hole is filled with developing medium.

[0020] By adopting the above technical solution, the receiving holes at the ends of the upper and lower clamping arms are filled with developing medium, and the position of the developing medium can be used to determine whether the upper and lower clamping arms are closed in place.

[0021] Preferably, the first end has a first slot and a second slot, and the second end has a first engaging portion and a second engaging portion. The upper clamping arm is connected and fixed to the lower clamping arm by engaging the first engaging portion and the first slot, and engaging the second engaging portion and the second slot.

[0022] This application also discloses a method for preparing the aforementioned biodegradable magnesium metal developing closure clip, comprising the following steps: S1. Laser cutting forms an integrated upper clamping arm, lower clamping arm, and connector, and mounting holes are machined on the connector; S2. Polish the integrated upper clamping arm, lower clamping arm and connecting parts with phosphate-ethylene glycol solution, ultrasonically clean with anhydrous ethanol and dry with a blower. S3. Manufacture the adjustment mechanism, install the adjustment mechanism into the mounting hole and fix the tube body in the mounting hole, rotate the rotating assembly to drive the partition to move so that the first sub-hole is in the maximum volume state. S4. Inject iodinated biodegradable polymer developing medium into the first sub-hole, and let it stand at room temperature until the developing medium solidifies to obtain the finished product.

[0023] By adopting the above technical solution, the upper clamping arm, lower clamping arm, and connecting parts are integrally laser-formed and polished to remove impurities. After assembling the adjustment mechanism, the partition is adjusted to its maximum volume, and then the imaging medium is injected and cured. The process is simple and suitable for mass production, with standardized basic specifications at the factory, and preoperative adjustments can cover a variety of clinical needs.

[0024] In summary, the present invention has at least one of the following beneficial technical effects: 1. The first sub-hole serves as a storage cavity for the radiopaque medium, filled with cured radiopaque medium to achieve postoperative imaging positioning. When the rotating assembly is rotated, the threaded engagement structure converts the rotational motion into linear feed motion along the axis of the mounting hole, stably driving the partition to translate axially along the mounting hole, changing the position of the partition within the mounting hole, and thus changing the effective accommodating space of the first sub-hole, thereby adjusting the effective filling depth of the radiopaque medium inside the first sub-hole. This structure breaks the limitation of the traditional magnesium clip radiopaque hole filling depth being fixed at the factory. Relying on only one set of uniformly sized clips, the filling amount of radiopaque medium can be adjusted by preoperatively translating the partition, simultaneously changing the intensity of the CT imaging signal and the contact area between the magnesium matrix and body fluid. It takes into account differentiated clinical needs such as long-term tumor follow-up and short-term superficial hemostasis, eliminating the need for separate mold production for different specifications, significantly reducing production and storage costs, and enhancing clinical adaptability. 2. The annular groove inside the tube engages with the elastic locking protrusion of the connecting column, producing a position indicator sound when moving, which facilitates medical staff to adjust the imaging depth. At the same time, the annular groove and the elastic locking protrusion can interlock with each other to prevent the partition from sliding on its own.

[0025] 3. The diameter of the first sub-hole gradually increases towards the partition. The cross-sectional area of ​​the developing medium is different at different positions along the axis of the first sub-hole. During subsequent scanning, the degree of degradation of this application in the human body can be determined based on the developing area. Attached Figure Description

[0026] Figure 1 This is a schematic diagram of the overall structure of the biodegradable magnesium metal developing and closing clip in the embodiments of this application; Figure 2 It is a cross-sectional view used to illustrate the adjustment mechanism; Figure 3 This is a schematic diagram illustrating the structure of the elastic card protrusion.

[0027] The attached diagram shows the following markings: 1. Upper clamping arm; 11. First end; 111. First slot; 112. Second slot; 2. Connector; 21. Mounting hole; 211. First sub-hole; 212. Second sub-hole; 22. Partition; 221. Partition head; 222. Connecting post; 2221. Elastic locking protrusion; 23. Adjustment mechanism; 231. Tube body; 2311. Annular groove; 232. Rotating assembly; 2321. First rotating post; 23211. Spline hole; 23212. Snap-fit ​​groove; 2322. Second rotating post; 23221. Spline part; 23222. Twisting part; 23223. Snap-fit ​​connector; 2323. Limiting ring; 3. Lower clamping arm; 31. Second end; 311. First snap-fit ​​part; 312. Second snap-fit ​​part; 4. Receiving hole. Detailed Implementation

[0028] The present invention will be further described in detail below with reference to the accompanying drawings.

[0029] In the description of this invention, it should be understood that the orientation descriptions, such as up, down, front, back, left, right, etc., are based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limiting this invention.

[0030] This application discloses a biodegradable magnesium metal developing and closing clip. (See also...) Figure 1 and Figure 2 The biodegradable magnesium metal developing closure clamp includes an upper clamping arm 1, a connector 2, and a lower clamping arm 3 connected in sequence. The upper clamping arm 1, connector 2, and lower clamping arm 3 are all made of magnesium metal, which has the ability to deform. The upper clamping arm 1, connector 2, and lower clamping arm 3 are an integral structure. The specific structure of the upper clamping arm 1, connector 2, and lower clamping arm 3 is existing technology and will not be described in detail here.

[0031] Reference Figure 2 The connector 2 has a mounting hole 21 that extends through the front and rear direction. A partition 22 is slidably connected to the mounting hole 21. A first sub-hole 211 and a second sub-hole 212 are formed on both sides of the partition 22 within the mounting hole 21. The first sub-hole 211 is located above the second sub-hole 212. The first sub-hole 211 is filled with a contrast medium for achieving postoperative imaging positioning. The contrast medium is an iodinated biodegradable polymer material. An adjustment mechanism 23 connected to the partition 22 is installed in the second sub-hole 212. The adjustment mechanism 23 is used to move the partition 22 along the axis of the mounting hole 21 to adjust the volume of the first sub-hole 211.

[0032] Reference Figure 2The adjustment mechanism 23 includes a tube 231 connected to the mounting hole 21. The tube 231 is made of materials such as polycaprolactone. In this embodiment, the tube 231 is bonded to the inner wall of the mounting hole 21 using a biodegradable adhesive such as a PCL-based adhesive. A rotating component 232 is threadedly connected to the inner wall of the tube 231 and is connected to the partition 22.

[0033] The rotating assembly 232, with its threaded engagement structure, converts rotational motion into linear feed motion along the axis of the mounting hole 21. This stably drives the partition 22 to translate axially along the mounting hole 21, changing its position within the hole and thus altering the effective accommodating space of the first sub-hole 211. This adjusts the effective filling depth of the developing medium within the first sub-hole 211. It should be noted that, typically, the partition 22 is lowered to its lowest position at the factory to facilitate filling and curing with sufficient developing medium. The cured developing medium retains some plasticity rather than being completely hard and brittle. Before surgery, by adjusting the position of the partition 22, the cured developing medium can be pushed out. External cleaning tools, such as micro-forceps or sterile gauze, can be used to remove any developing medium pushed outside the first sub-hole 211.

[0034] This application breaks through the limitation that the filling depth of the imaging hole of traditional magnesium clips is fixed at the factory. With just one set of clips of uniform specifications, the filling amount of imaging medium can be adjusted by the preoperative translational partition 22, which simultaneously changes the intensity of CT imaging signal and the contact area of ​​magnesium matrix fluid, taking into account the differentiated clinical needs such as long-term tumor follow-up and short-term superficial hemostasis.

[0035] Reference Figure 2 and Figure 3 The rotating assembly 232 includes a first rotating column 2321 and a second rotating column 2322. The first rotating column 2321 and the second rotating column 2322 are made of materials such as polycaprolactone. The first rotating column 2321 and the second rotating column 2322 are coaxially arranged with the mounting hole 21. The outer circumference of the first rotating column 2321 is threaded to the tube body 231. The upper end of the first rotating column 2321 is connected to the partition 22. The first rotating column 2321 can move up and down after rotation. A spline hole 23211 is opened at the lower end of the first rotating column 2321. The second rotating column 2322 has a spline portion 23221, which is connected to the spline hole 23211. Therefore, the second rotating column 2322 can slide up and down relative to the first rotating column 2321 and can drive the first rotating column 2321 to rotate. The second rotating column 2322 has a twisting portion 23222, the diameter of which is smaller than the diameter of the second rotating column 2322. After the second rotating column 2322 can slide, the twisting portion 23222 is exposed to the external environment.

[0036] When in use, pulling out the second rotating column 2322 exposes the screwing part 23222. Rotating the screwing part 23222 will drive the first rotating column 2321 to rotate through the connection and cooperation between the spline part 23221 and the spline hole 23211. This will drive the first rotating column 2321 to rotate and move. The movement of the first rotating column 2321 can drive the partition 22 to move up and down.

[0037] Reference Figure 2 and Figure 3 To ensure the reliable positioning of the first rotating post 2321 relative to the second rotating post 2322 within the human body and to prevent the second rotating post 2322 from detaching from the first rotating post 2321, the lower end of the first rotating post 2321 has a locking groove 23212, and the second rotating post 2322 has a locking connector 23223. Under normal conditions, the locking connector 23223 is engaged with the locking groove 23212, and the second rotating post 2322 is located within the mounting hole 21. When the second rotating post 2322 is pulled down, the locking connector 23223 disengages from the locking groove 23212, and the rotating part 23222 is located outside the mounting hole 21. Furthermore, a limiting ring 2323 is provided on the inner wall of the spline hole 23211. The limiting ring 2323 is located below the second rotating post 2322, and when the second rotating post 2322 moves downward, it presses against the limiting ring 2323 and is thus limited.

[0038] Reference Figure 2 The diameter of the first sub-hole 211 gradually increases along the axis of the mounting hole 21 towards the partition 22. The partition 22 has elastic deformation capability and is integrally molded from medical-grade biodegradable elastic polymer. The material is selected as PCL-PEG block copolymer or medical-grade biodegradable polyurethane, and it has good elastic compression and rebound deformation capability. The partition 22 includes a partition head 221 slidably attached to the mounting hole 21 and a connecting post 222 connected to the lower end of the partition head 221. The connecting post 222 is rotatably connected to the first rotating post 2321.

[0039] The partition head 221 seals and isolates the developing medium. Since the connecting column 222 and the first rotating column 2321 can rotate relative to each other, the first rotating column 2321 does not transmit torsional force when it rotates and feeds, which can ensure that the partition head 221 can move reliably to push the developing medium and thus adjust the amount of developing medium in the first sub-hole 211.

[0040] Reference Figure 2 and Figure 3 To facilitate adjustment of imaging depth by medical staff, the tube body 231 includes multiple annular grooves 2311 arranged along the axial direction on the inner side wall, and the connecting post 222 includes an elastic locking protrusion 2221 on the outer side wall. The elastic locking protrusion 2221 can be engaged with any annular groove 2311 and emit a prompt sound or tactile feedback. The annular grooves 2311 and the elastic locking protrusion 2221 can also interlock with each other to prevent the partition member 22 from sliding on its own.

[0041] Reference Figure 1 To facilitate determining whether the upper clamping arm 1 and the lower clamping arm 3 are properly closed, the end of the upper clamping arm 1 away from the connector 2 is the first end 11, and the end of the lower clamping arm 3 away from the connector 2 is the second end 31. Both the first end 11 and the second end 31 have receiving holes 4, and each receiving hole 4 is filled with developing medium, which is also an iodinated biodegradable polymer material.

[0042] Reference Figure 1 To ensure reliable closure of the upper clamping arm 1 and the lower clamping arm 3, the first end 11 has a first slot 111 and a second slot 112, which are arranged vertically. The second end 31 has a first engaging part 311 and a second engaging part 312. The upper clamping arm 1 is connected and fixed to the lower clamping arm 3 by engaging the first engaging part 311 and the first slot 111, and engaging the second engaging part 312 and the second slot 112. The engaging part 311 and the first slot 111, and engaging the second engaging part 312 and the second slot 112 form a double-locking fixation, which makes the upper clamping arm 1 and the lower clamping arm 3 have a high locking force.

[0043] The implementation principle of the biodegradable magnesium metal imaging closure clip in this application embodiment is as follows: when used before surgery, pull out the second rotating column 2322 to expose the twisting part 23222. Rotating the twisting part 23222 drives the second rotating column 2322 to rotate, thereby driving the first rotating column 2321 to rotate and move. The movement of the first rotating column 2321 will drive the partition 22 to move up and down to push the imaging medium, thereby adjusting the effective filling depth of the imaging medium inside the first sub-hole 211.

[0044] Reference Figures 1-3 This application also discloses a method for preparing a biodegradable magnesium metal developing closure clip, comprising the following steps: S1. Laser cut an integral upper clamping arm 1, lower clamping arm 3 and connector 2 on a magnesium substrate. A mounting hole 21 is machined on the connector 2 and the mounting hole 21 is drilled through along the thickness direction of the connector 2. S2. Polish the integrated upper clamping arm 1, lower clamping arm 3 and connecting piece 2 with phosphate-ethylene glycol solution, ultrasonically clean with anhydrous ethanol and dry with forced air. In this embodiment, the closing clamp is completely immersed in a phosphoric acid-ethylene glycol solution for polishing at a temperature of 50°C for 1 minute. The polished closing clamp is then completely immersed in analytical grade anhydrous ethanol for ultrasonic cleaning at a temperature of 20°C for 1 minute. Finally, it is dried in a forced-air drying oven at a temperature of 85°C for 5 minutes.

[0045] In other embodiments, the closure clip was polished by completely immersing it in a phosphate-ethylene glycol solution at a temperature of 55°C for 2 minutes. The polished closure clip was then completely immersed in analytical grade anhydrous ethanol and ultrasonically cleaned at a temperature of 25°C for 2 minutes. Finally, it was dried in a forced-air drying oven at a temperature of 90°C for 2 minutes.

[0046] S3. Manufacture the adjustment mechanism 23, install the adjustment mechanism 23 into the mounting hole 21 and fix the tube body 231 to the mounting hole 21, rotate the rotating assembly 232 to drive the partition 22 to move so that the first sub-hole 211 is in the maximum volume state. S4. Inject iodinated biodegradable polymer developing medium into the first sub-hole 211, and let it stand at room temperature for 5-10 hours until the developing medium solidifies to obtain the finished product.

[0047] The aforementioned developing medium is, for example, a 5%-10% solution obtained by dissolving iodinated polycaprolactone or iodinated polylactide in an organic solvent under stirring at room temperature.

[0048] The embodiments described herein are preferred embodiments of the present invention and are not intended to limit the scope of protection of the present invention. Therefore, all equivalent changes made in accordance with the structure, shape, and principle of the present invention should be covered within the scope of protection of the present invention.

Claims

1. A biodegradable magnesium metal developing closure clip, characterized in that: The device includes an upper clamping arm (1), a connector (2), and a lower clamping arm (3) connected in sequence. The connector (2) has a mounting hole (21), and a partition (22) is slidably connected to the mounting hole (21). The mounting hole (21) has a first sub-hole (211) and a second sub-hole (212) formed on both sides of the partition (22). The first sub-hole (211) is filled with a developing medium, and the second sub-hole (212) is equipped with an adjustment mechanism (23) connected to the partition (22). The adjustment mechanism (23) is used to drive the partition (22) to move along the axis of the mounting hole (21). The adjustment mechanism (23) includes a tube (231) connected to the mounting hole (21), and a rotating assembly (232) is threadedly connected to the tube (231). The rotating assembly (232) is connected to the partition (22).

2. The biodegradable magnesium metal developing closure clip according to claim 1, characterized in that: The rotating assembly (232) includes a first rotating column (2321) and a second rotating column (2322). The first rotating column (2321) is threaded to the tube body (231) and connected to the partition (22). The end of the first rotating column (2321) has a spline hole (23211). The second rotating column (2322) has a spline portion (23221) connected to the spline hole (23211). The second rotating column (2322) has a twisting portion (23222). The second rotating column (2322) can slide so that the twisting portion (23222) is exposed to the external environment.

3. The biodegradable magnesium metal developing closure clip according to claim 2, characterized in that: The partition (22) includes a partition head (221) slidably attached to the mounting hole (21) and a connecting post (222) connected to the partition head (221), wherein the connecting post (222) is rotatably connected to the first rotating post (2321).

4. The biodegradable magnesium metal developing closure clip according to claim 3, characterized in that: The tube body (231) includes multiple annular grooves (2311) arranged along the axial direction on the inner side wall, and the connecting column (222) includes an elastic locking protrusion (2221) on the outer side wall. The elastic locking protrusion (2221) can be locked into any annular groove (2311) and emit a prompt sound.

5. The biodegradable magnesium metal developing closure clip according to claim 2, characterized in that: The first rotating column (2321) has a snap-fit ​​groove (23212), and the second rotating column (2322) has a snap-fit ​​connector (23223); under normal conditions, the snap-fit ​​connector (23223) is snapped into the snap-fit ​​groove (23212), and the second rotating column (2322) is located in the mounting hole (21).

6. The biodegradable magnesium metal developing closure clip according to claim 1, characterized in that: The diameter of the first sub-hole (211) gradually increases along the axial direction of the mounting hole (21) toward the partition (22), which has the ability to deform.

7. The biodegradable magnesium metal developing closure clip according to claim 1, characterized in that: The end of the upper clamping arm (1) away from the connector (2) is the first end (11), and the end of the lower clamping arm (3) away from the connector (2) is the second end (31). Both the first end (11) and the second end (31) have receiving holes (4), and each receiving hole (4) is filled with developing medium.

8. The biodegradable magnesium metal developing closure clip according to claim 7, characterized in that: The first end (11) has a first slot (111) and a second slot (112), and the second end (31) has a first snap-fit ​​part (311) and a second snap-fit ​​part (312). The upper clamping arm (1) is connected and fixed to the lower clamping arm (3) by snapping the first snap-fit ​​part (311) and the first slot (111) and snapping the second snap-fit ​​part (312) and the second slot (112).

9. A method for preparing the biodegradable magnesium metal developing closure clip according to any one of claims 1-8, characterized in that: Includes the following steps: S1. Laser cutting forms an integrated upper clamping arm (1), lower clamping arm (3) and connector (2), and a mounting hole (21) is machined on the connector (2); S2. Polish the integrated upper clamping arm (1), lower clamping arm (3) and connector (2) with phosphate-ethylene glycol solution, ultrasonically clean with anhydrous ethanol and blow dry. S3. Manufacture the adjustment mechanism (23), install the adjustment mechanism (23) into the mounting hole (21) and fix the tube body (231) in the mounting hole (21), rotate the rotating assembly (232) to drive the partition (22) to move so that the first sub-hole (211) is in the maximum volume state; S4. Iodinated biodegradable polymer developing medium is injected into the first sub-hole (211), and the finished product is obtained after standing at room temperature until the developing medium solidifies.

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