Anti-aging and deep wrinkle-removing firming milk and method for preparing the same

Abstract

The present application provides an anti-aging and deep wrinkle-removing firming milk, which comprises the following components by mass fraction: water in excess, 5-15% of Schizochytrium ferment filtrate, 3-8% of methylpropylene glycol, 1-3% of dimethicone / vinyl dimethicone crosspolymer, 2-5% of aminobutyric acid, 2-5% of butanediol, 2-5% of glycerin, 1-3% of polysorbate-20, 0.5-2% of hydrolyzed collagen, 0.5-2% of chondrus crispus, 1-3% of sorbitan laurate, 0.3-0.8% of 1,2-hexanediol, 1-3% of propylene glycol, 0.5-1.5% of laureth-25, 0.5-1.5% of laureth-3, and 0.5-2% of tetrahydro methyl pyrimidine carboxylic acid; the present application realizes the significant improvement on deep wrinkles through the synergistic design of multiple components and multiple targets. The experimental data show that the firming milk is significantly better than each component alone or simple combination in reducing the depth and number of wrinkles, improving skin elasticity and firmness, and at the same time, the patch test verifies that the irritation is extremely low, and it is suitable for long-term use of various skin.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, and in particular to an anti-aging and deep wrinkle-removing firming lotion and its preparation method. Background Technology

[0002] Skin aging is a complex process, mainly manifested as the loss of collagen and elastin fibers, weakening of the skin barrier function, and the appearance of wrinkles and sagging. The formation of deep wrinkles (usually referring to those with a depth >70μm) is closely related to the collapse of the dermal structure, long-term contraction of facial muscles, and decreased skin elasticity.

[0003] Most anti-aging products on the market today are based on a single or a few active ingredients, such as retinol, styrax, and vitamin C. Their effects are mainly focused on promoting keratin metabolism or stimulating superficial collagen production. They have limited effect on improving deep wrinkles and often take a long time to show results.

[0004] Peptide ingredients, such as acetyl hexapeptide-8 and palmitoyl pentapeptide-4, have become popular ingredients in the anti-aging field because they can mimic growth factors and promote collagen synthesis. However, peptides have problems such as relatively large molecular weight, limited transdermal absorption efficiency, and easy inactivation in the formulation, which limit their full efficacy.

[0005] In addition, some highly active ingredients, such as GABA, have been shown to have an immediate effect of soothing and smoothing expression lines, but at higher concentrations they may irritate sensitive skin, limiting their application concentration and target population in formulations.

[0006] Plant extracts such as rosewood bark extract (rich in pterostilbene) and tomato extract (rich in lycopene and various antioxidants) possess excellent antioxidant and anti-inflammatory potential, but their specific efficacy in combating deep wrinkles and their synergistic mechanisms with other active ingredients have not been fully explored and utilized. Fermentation products, such as Bifida ferment lysate filtrate, while possessing repairing and soothing effects, have not been systematically studied for their synergistic effects with specific peptides and plant extracts on deep wrinkles and skin firmness. Therefore, this paper proposes an anti-aging and deep wrinkle-removing firming lotion and its preparation method. Summary of the Invention

[0007] In view of this, embodiments of the present invention provide an anti-aging and deep wrinkle removal firming lotion and its preparation method to solve or alleviate the technical problems existing in the prior art, and at least provide a beneficial option.

[0008] The technical solution of this invention is implemented as follows: an anti-aging and deep wrinkle-removing firming lotion, comprising the following components by mass fraction: Water balance, 5-15% Bifida ferment filtrate, 3-8% methylpropylene glycol, 1-3% polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer, 2-5% GABA, 2-5% butanediol, 2-5% glycerol, 1-3% polysorbate-20, 0.5-2% hydrolyzed collagen, 0.5-2% Euglena polysaccharide, 1-3% sorbitan laurate, 0.3-0.8% 1,2-hexanediol 1-3% propylene glycol, 0.5-1.5% lauryl ether-25, 0.5-1.5% lauryl ether-3, 0.5-2% tetrahydromethylpyrimidine carboxylic acid, 0.2-0.6% polyacrylate crosspolymer-6, 0.1-0.3% hydroxyethyl cellulose, 0.05-0.15% sodium hyaluronate, 1-5% hydroxypropyl tetrahydropyrantriol, 1-5% Dalbergia odorifera bark extract, 1-10% tomato extract; And a complex trace additive component consisting of acetyl hexapeptide-8, tripeptide-1, acetyl octapeptide-3, palmitoyl tripeptide-1, hexapeptide-9, palmitoyl tripeptide-5, palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7, arginine / lysine polypeptide, arginine, phenoxyethanol, capryloyl hydroxamic acid, p-hydroxyacetophenone, soluble collagen, disodium EDTA, glyceryl caprylate, ethylhexylglycerin, Swertia japonica extract, Gentiana scabra root extract, Paeonia lactiflora root extract, 1,2-pentanediol, Centella asiatica extract, Artemisia capillaris extract, Panax ginseng root extract, Dendrobium officinale extract, and Ginkgo biloba leaf extract, with a total addition amount of 0.5%-3% of the total mass.

[0009] In some embodiments, the mass fraction of each component in the composite trace additive component is: 0.05-0.15% Acetyl hexapeptide-8, 0.01-0.05% Tripeptide-1, 0.01-0.05% Acetyl octapeptide-3, 0.02-0.08% Palmitoyl tripeptide-1, 0.01-0.05% Hexapeptide-9, 0.02-0.08% Palmitoyl tripeptide-5, 0.03-0.1% Palmitoyl pentapeptide-4, 0.02-0.08% Palmitoyl tetrapeptide-7, 0.05-0.15% Arginine / Lysine polypeptide, 0.1-0.3% Arginine, 0.4-0.7% Phenoxyethanol, 0.1-0.3% Capryloyl hydroxamic acid, 0.1-0.3% p-hydroxyacetophenone, 0.01-0.05% soluble collagen, 0.01-0.03% disodium EDTA, 0.05-0.15% glyceryl caprylate, 0.05-0.15% ethylhexylglycerin, 0.05-0.15% Swertia japonica extract, 0.05-0.15% Gentiana scabra root extract, 0.05-0.15% Paeonia lactiflora root extract, 0.5-1.5% 1,2-pentanediol, 0.1-0.3% Centella asiatica extract, 0.1-0.3% Artemisia capillaris extract, 0.1-0.3% Panax ginseng root extract, 0.1-0.3% Dendrobium officinale extract, and 0.1-0.3% Ginkgo biloba leaf extract.

[0010] In some embodiments, it comprises the following components by mass fraction: The product contains: water balance, 10% Bifida ferment filtrate, 5% methyl propylene glycol, 2% polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer, 3% aminobutyric acid, 3% butylene glycol, 3% glycerol, 2% polysorbate-20, 1% hydrolyzed collagen, 1% Euglena polysaccharide, 2% sorbitan lauryl ester, 0.5% 1,2-hexanediol, 2% propylene glycol, 1% lauryl ether-25, 1% lauryl ether-3, 1% tetrahydromethylpyrimidine carboxylic acid, 0.4% polyacrylate crosspolymer-6, 0.2% hydroxyethyl cellulose, 0.1% sodium hyaluronate, 3% hydroxypropyl tetrahydropyrantriol, 3% Dalbergia odorifera bark extract, and 5% tomato extract. The total amount of the composite trace additive component is 1.5%.

[0011] In some embodiments, the tomato extract is prepared by: Take fresh tomatoes, homogenize and crush them, add 5-10 times their weight of ethanol aqueous solution, reflux and extract at 40-60℃ for 2-4 hours, filter, concentrate the filtrate under reduced pressure until there is no alcohol taste, and the tomato extract is obtained.

[0012] In some embodiments, the preparation method of the Dalbergia odorifera bark extract is as follows: Take dried rosewood bark, crush it, add 10-15 times its weight of propylene glycol aqueous solution, extract at 50-70℃ for 3-5 hours, filter, and the filtrate is obtained.

[0013] In some embodiments, the extracts of Japanese swert, gentian root extract, peony root extract, centella asiatica extract, artemisia capillaris extract, ginseng root extract, dendrobium officinale extract, and ginkgo leaf extract are extracts obtained by extracting, filtering, and concentrating their respective dried raw materials with water or alcohol-water solutions.

[0014] A method for preparing an anti-aging and deep wrinkle-removing firming lotion as described above includes the following steps: S1. Take the amount of deionized water in the formula and add it to the aqueous phase pot. While stirring, slowly add polyacrylate cross-linked polymer-6 and hydroxyethyl cellulose. After dispersing evenly, add aminobutyric acid, butanediol, glycerol, propylene glycol, 1,2-pentanediol and disodium EDTA. Heat to 75-80℃ and stir evenly to obtain the aqueous phase. Keep it warm for later use. S2. Take the prescribed amounts of methyl propylene glycol, polydimethylsiloxane / vinyl polydimethylsiloxane cross-linked polymer, sorbitan laurate, lauryl alcohol polyether-25, and lauryl alcohol polyether-3 and add them to the oil phase pot. Heat to 75-80℃, stir evenly, and keep the oil phase warm for later use. S3. Slowly pump the oil phase into the aqueous phase and homogenize at high speed for 5-10 minutes to form a colostrum; S4. Slowly cool the colostrum to 45-50℃, then add the following in sequence: Bifida ferment filtrate, hydrolyzed collagen, Euglena polysaccharide, tetrahydromethylpyrimidine carboxylic acid, sodium hyaluronate, hydroxypropyl tetrahydropyrantriol, Dalbergia odorifera bark extract, tomato extract, polysorbate-20, and the complex trace additives. Stir well. S5. Continue cooling to 35-40℃, add pH adjuster (such as arginine) to adjust pH to 5.5-6.5, add preservatives phenoxyethanol, capryloyl hydroxamic acid, p-hydroxyacetophenone, glyceryl caprylate, ethylhexylglycerin and antioxidants, stir evenly, filter and discharge, fill into bottles to obtain the final product.

[0015] In some embodiments, the firming emulsion is an oil-in-water emulsion.

[0016] In some embodiments, the deep wrinkles refer to wrinkles with a depth greater than 70 μm.

[0017] In some embodiments, it has a synergistic effect in reducing wrinkle depth, reducing the number of wrinkles, and improving skin elasticity.

[0018] In some embodiments, the core anti-aging synergy consists of: GABA (aminobutyric acid) providing immediate soothing and smoothing effects on expression lines; hydroxypropyl tetrahydropyranotriol (Pro-Xylane) promoting glycosaminoglycan synthesis and plumping the dermal structure; and palm bark extract and tomato extract providing potent antioxidant protection and reducing collagen degradation. This combination works synergistically to combat the formation of deep wrinkles from three dimensions: immediate smoothing, structural filling, and protection at the source.

[0019] The peptide-based collagen-boosting peptide group includes signal peptides such as acetyl hexapeptide-8 and acetyl octapeptide-3, which mimic growth factors to inhibit neurotransmitter release and soothe dynamic wrinkles; and carrier peptides such as palmitoyl tripeptide-1 and palmitoyl pentapeptide-4, which promote collagen and elastin synthesis. This peptide combination works synergistically with the core anti-aging group to strengthen the skin's support network by both inhibiting contraction and promoting regeneration.

[0020] Deep Nourishment and Repair Complex: Bifida Ferment Lysate Filtrate, Hydrolyzed Collagen, Euglena Polysaccharide, Tetrahydromethylpyrimidine Carboxylic Acid (Ectoin), and various plant extracts (such as Centella Asiatica, Ginseng, Dendrobium officinale, etc.) together constitute a deep nourishment and barrier repair system, providing a healthy skin environment for the anti-aging process and enhancing skin tolerance and self-healing ability.

[0021] Matrix and Penetration System: A stable, smooth-feeling emulsion matrix is ​​constructed using a scientifically designed emulsification system (polysorbate-20, sorbitan laurate, etc.) and thickening system (polyacrylate crosspolymer-6, hydroxyethyl cellulose). Methylpropylene glycol and propylene glycol act as penetration enhancers, helping active ingredients to better penetrate to the site of action.

[0022] The embodiments of the present invention have the following advantages due to the adoption of the above technical solutions: This invention achieves significant improvement in deep wrinkles through a synergistic design of multiple components and multiple targets. Experimental data shows that this firming lotion is significantly more effective than individual components or simple combinations in reducing wrinkle depth and number, and improving skin elasticity and firmness. Furthermore, patch testing has verified that it has extremely low irritation and is suitable for long-term use on all skin types.

[0023] The above overview is for illustrative purposes only and is not intended to be limiting in any way. Detailed Implementation

[0024] In the following description, only certain exemplary embodiments are briefly described. As those skilled in the art will recognize, the described embodiments can be modified in various ways without departing from the spirit or scope of the invention.

[0025] It is important to note that terms such as "first," "second," "symmetric," "array," "set in," and "set with" are used only to distinguish between descriptive and positional descriptions and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Therefore, features specified with terms such as "first" or "symmetric" may explicitly or implicitly include one or more of that feature; similarly, when the quantity of certain features is not limited by words such as "two" or "three," it should be noted that such features also explicitly or implicitly include one or more features.

[0026] In this invention, unless otherwise explicitly specified and limited, terms such as “installation,” “connection,” and “fixation” should be interpreted broadly; for example, they can be fixed connections, detachable connections, or integral moldings; they can be mechanical connections, direct connections, welding, or indirect connections through an intermediate medium; they can be internal connections between two components or the interaction between two components.

[0027] Example 1 This invention provides an anti-aging and deep wrinkle-removing firming lotion, which comprises the following components by mass fraction: The product contains: water balance, 10% Bifida ferment filtrate, 5% methyl propylene glycol, 2% polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer, 3% aminobutyric acid, 3% butylene glycol, 3% glycerol, 2% polysorbate-20, 1% hydrolyzed collagen, 1% Euglena polysaccharide, 2% sorbitan lauryl ester, 0.5% 1,2-hexanediol, 2% propylene glycol, 1% lauryl ether-25, 1% lauryl ether-3, 1% tetrahydromethylpyrimidine carboxylic acid, 0.4% polyacrylate crosspolymer-6, 0.2% hydroxyethyl cellulose, 0.1% sodium hyaluronate, 3% hydroxypropyl tetrahydropyrantriol, 3% Dalbergia odorifera bark extract, and 5% tomato extract. And a total of 1.5% of the compound trace additives.

[0028] In some embodiments, the mass fraction of each component in the composite trace additive component is: 0.10% Acetyl hexapeptide-8, 0.03% Tripeptide-1, 0.03% Acetyl octapeptide-3, 0.05% Palmitoyl tripeptide-1, 0.03% Hexapeptide-9, 0.05% Palmitoyl tripeptide-5, 0.06% Palmitoyl pentapeptide-4, 0.05% Palmitoyl tetrapeptide-7, 0.10% Arginine / Lysine peptide, 0.20% Arginine (for pH adjustment), 0.5% Phenoxyethanol, 0.15% Capryloyl hydroxamic acid, 0.15% p-hydroxybenzene Ethyl ketone, 0.02% soluble collagen, 0.02% disodium EDTA, 0.10% glyceryl caprylate, 0.10% ethylhexylglycerin, 0.10% Japanese swert extract, 0.10% gentian root extract, 0.10% peony root extract, 1.0% 1,2-pentanediol, 0.20% centella asiatica extract, 0.20% artemisia capillaris extract, 0.20% ginseng root extract, 0.20% dendrobium officinale extract, and 0.20% ginkgo biloba leaf extract.

[0029] In some embodiments, the tomato extract is prepared as follows: Take fresh tomatoes, homogenize and crush them, add 5-10 times their weight of ethanol aqueous solution, reflux and extract at 40-60℃ for 2-4 hours, filter, concentrate the filtrate under reduced pressure until there is no alcohol taste, and the tomato extract is obtained.

[0030] In some embodiments, the preparation method of the extract from the bark of the Dalbergia odorifera tree is as follows: Take dried rosewood bark, crush it, add 10-15 times its weight of propylene glycol aqueous solution, extract at 50-70℃ for 3-5 hours, filter, and the filtrate is obtained.

[0031] In some embodiments, the extracts of Japanese swert, gentian root extract, peony root extract, centella asiatica extract, artemisia capillaris extract, ginseng root extract, dendrobium officinale extract, and ginkgo leaf extract are extracts obtained by extracting, filtering, and concentrating their respective dried raw materials with water or alcohol-water solutions.

[0032] A method for preparing the anti-aging and deep wrinkle-removing firming lotion as described above includes the following steps: S1. Take the amount of deionized water in the formula and add it to the aqueous phase pot. While stirring (200 rpm), slowly add polyacrylate cross-linked polymer-6 and hydroxyethyl cellulose. Stir and disperse for 20 minutes until uniform and free of lumps. Add aminobutyric acid, butanediol, glycerol, propylene glycol, 1,2-pentanediol, and disodium EDTA. Heat to 80°C and stir evenly to obtain the aqueous phase. Keep warm for later use. S2. Take the prescribed amounts of methyl propylene glycol, polydimethylsiloxane / vinyl polydimethylsiloxane cross-linked polymer, sorbitan laurate, lauryl alcohol polyether-25, and lauryl alcohol polyether-3 and add them to the oil phase pot. Heat to 80°C, stir evenly, and keep the oil phase warm for later use. S3. Slowly pump the oil phase into the aqueous phase and homogenize at high speed (5000 rpm) for 8 minutes to form a pre-emulsion; S4. Slowly cool the colostrum to 50°C, then add the Bifida ferment filtrate, hydrolyzed collagen, Euglena polysaccharide, tetrahydromethylpyrimidine carboxylic acid, sodium hyaluronate, hydroxypropyl tetrahydropyrantriol, Dalbergia odorifera bark extract, tomato extract, and polysorbate-20 in sequence. Stir well, then slowly add all the components of the pre-mixed "complex trace additives" except for the pH adjuster and some preservatives, and continue stirring until well mixed. S5. Continue cooling to 40℃, add pH adjuster (such as arginine) to adjust pH to 6.0, add preservatives phenoxyethanol, capryloyl hydroxamic acid, p-hydroxyacetophenone, glyceryl caprylate, ethylhexylglycerin and antioxidant, stir evenly, filter through a 100-mesh filter, fill into bottles, and the product is ready.

[0033] Example 2 Based on Example 1, the proportions of the core anti-aging ingredients were adjusted: 2% GABA, 4% hydroxypropyl tetrahydropyrantriol, 4% Dalbergia odorifera bark extract, 8% tomato extract and 12% Bifida ferment filtrate. The other components and preparation methods are the same as in Example 1.

[0034] Example 3 Based on Example 1, the proportions of the matrix components were adjusted: 1.5% polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer, 6% methyl propylene glycol, 1.5% polysorbate-20, 1.5% sorbitan laurate; The other components and preparation methods are the same as in Example 1.

[0035] In this embodiment, specifically, a comparative design is shown below: Comparative Example 1: GABA was removed from the formula and replaced with an equal amount of water.

[0036] Comparative Example 2: Hydroxypropyltetrahydropyranotriol was removed from the formulation and replaced with an equal amount of water.

[0037] Comparative Example 3: Remove the palm bark extract and tomato extract from the formula and replace them with an equal amount of water.

[0038] Comparative Example 4: All peptide components (acetyl hexapeptide-8, etc.) in the "complex trace additive components" of the formula were removed and replaced with an equal amount of water.

[0039] Comparative Example 5: Remove the Bifida ferment filtrate and all plant extracts (Swertia japonica, Centella asiatica, etc.) from the formula and replace them with an equal amount of water.

[0040] Comparative Example 6: The formulation contains only 5% GABA and a basic matrix (water, emulsifier, thickener, preservative).

[0041] Experimental data and results analysis: Experimental Example 1: Human Skin Patch Test (Safety Evaluation) Refer to the skin occlusive patch test method in the "Cosmetic Safety Technical Specifications".

[0042] 240 healthy volunteers (aged 20-50) were selected and randomly divided into 8 groups of 30 each.

[0043] Approximately 0.02g of the products from Examples 1-3 and Comparative Examples 1-6 were placed in the spot test chamber and applied to the flexor side of the forearm of the subjects. The patches were removed after 24 hours. Skin reactions were observed at 0.5h, 24h, and 48h after removal and interpreted according to the standards in Table 1.

[0044] Table 1. Grading Standards for Adverse Skin Reactions The statistical results are shown in Table 2: Table 2. Statistical analysis of patch test results (48-hour observation) Results analysis: Examples 1-3 all demonstrated excellent safety, with a negative reaction rate of over 96.7%. Although a few suspicious reactions occurred in Comparative Examples 1-5, the overall safety was good.

[0045] It is noteworthy that a relatively high proportion of positive reactions (including strong positive and extremely strong positive) were observed in ratio 6 (containing only 5% GABA), indicating that high concentrations of GABA alone are highly irritating.

[0046] Although the formulation of this invention (Example 1) contains 3% GABA, its irritant properties are significantly reduced through scientific compounding with other ingredients, demonstrating the success of this formulation in reducing potential irritation.

[0047] Experimental Example 2: Efficacy Evaluation Trial Subject selection: 160 healthy female volunteers aged 35-60 years with deep facial wrinkles (70-150μm as detected by Primos lite), decreased skin elasticity, and anti-aging needs were selected.

[0048] They were randomly divided into 8 groups, with 20 people in each group.

[0049] Directions for use: After cleansing in the morning and evening, subjects should take approximately 0.5g of the test sample and apply it evenly to one side of the face and neck, gently patting until absorbed. Continue use for 28 days. The other side of the face will serve as a control and will not be used with the product.

[0050] Evaluation indicators and instruments: Skin elasticity: The MPA580 elastometer was used to measure the parameter R2 value (the ratio of the rebound amount without negative pressure to the maximum stretch amount with negative pressure; the closer it is to 1, the better the elasticity), at D0, D7, D14, and D28.

[0051] Wrinkle depth and number: Using the Primos lite 3D skin rapid imaging system, wrinkle images of specific areas of the face (such as the corners of the eyes and mouth) were captured at D0, D14, and D28, and the average wrinkle depth and total number of wrinkles were analyzed.

[0052] Skin firmness: The skin firmness F4 value (the speed at which the skin returns to its original position after being stretched, the higher the value, the firmer the skin) is measured using a Cutometer® dual-hole probe at D0 and D28.

[0053] Data processing: SPSS software was used for statistical analysis to compare differences before and after the use of the data, as well as differences between groups.

[0054] Table 3. Improvement in skin elasticity (R² value) (mean ± standard deviation) The R² value of group D28 in Example 1 was significantly improved, significantly higher than that of each comparative group (p<0.05 or p<0.01).

[0055] Comparative ratio 6 (aminobutyric acid) showed almost no improvement, proving that it is ineffective in improving skin elasticity when used alone.

[0056] Table 4. Improvement in the depth (μm) of crow's feet (mean ± standard deviation) Table 5. Improvement in the number of crow's feet wrinkles (mean ± standard deviation) In Example 1 group, the percentage reduction in wrinkle depth and number was the greatest at D28, which was significantly better than the comparative groups.

[0057] Comparative example 6 showed almost no improvement, indicating that GABA is ineffective against deep wrinkles.

[0058] Comparative Examples 1, 2, and 4 showed some effect, but were far less effective than Example 1, indicating that there is a synergistic effect among the core components.

[0059] Comparative ratios 3 and 5 showed the worst results, highlighting the importance of antioxidants and deep repair complexes.

[0060] Table 6. Improvement in Skin Firmness (F4 Value) (Mean ± Standard Deviation) Within 28 days, the example group showed a reduction of more than 30% in average wrinkle depth and a reduction of about 40% in the number of wrinkles, demonstrating significant effects. The effects of each comparative group were significantly weaker than those of the example group. In particular, the effects decreased significantly after removing the core anti-aging group (comparative examples 1-3) or the repair group (comparative example 5), and the effects were also reduced after removing the peptide (comparative example 4). This fully demonstrates the synergistic effect between the core ingredients, peptide groups and repair groups in the formulation of this invention, rather than a simple additive effect.

[0061] In the example group, the skin elasticity R2 value increased by about 25%, and the firmness F4 value increased by about 21%, which is much greater than that of the comparison groups. In particular, the comparison group 6 (aminobutyric acid) had no positive effect on skin elasticity and firmness, and even had a slight negative effect on firmness. This is consistent with its short-term smooth muscle mechanism and cannot fundamentally improve the skin structure. This invention achieves long-term elasticity and firmness improvement by promoting collagen regeneration and dermal matrix reconstruction.

[0062] By combining patch testing and efficacy testing, the product of this invention achieves comprehensive and significant improvement in deep wrinkles, skin elasticity, and firmness while ensuring high safety, solving the problems of traditional highly active anti-aging ingredients being highly irritating and having limited effects.

[0063] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any person skilled in the art can easily conceive of various variations or substitutions within the technical scope disclosed in the present invention, and these should all be included within the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be determined by the scope of the claims.

Claims

1. An anti-aging and deep wrinkle-removing firming lotion, characterized in that, It contains the following components by mass fraction: Water balance, 5-15% Bifida ferment filtrate, 3-8% methylpropylene glycol, 1-3% polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer, 2-5% GABA, 2-5% butanediol, 2-5% glycerol, 1-3% polysorbate-20, 0.5-2% hydrolyzed collagen, 0.5-2% Euglena polysaccharide, 1-3% sorbitan laurate, 0.3-0.8% 1,2-hexanediol 1-3% propylene glycol, 0.5-1.5% lauryl ether-25, 0.5-1.5% lauryl ether-3, 0.5-2% tetrahydromethylpyrimidine carboxylic acid, 0.2-0.6% polyacrylate crosspolymer-6, 0.1-0.3% hydroxyethyl cellulose, 0.05-0.15% sodium hyaluronate, 1-5% hydroxypropyl tetrahydropyrantriol, 1-5% Dalbergia odorifera bark extract, 1-10% tomato extract; And a complex trace additive component consisting of acetyl hexapeptide-8, tripeptide-1, acetyl octapeptide-3, palmitoyl tripeptide-1, hexapeptide-9, palmitoyl tripeptide-5, palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7, arginine / lysine polypeptide, arginine, phenoxyethanol, capryloyl hydroxamic acid, p-hydroxyacetophenone, soluble collagen, disodium EDTA, glyceryl caprylate, ethylhexylglycerin, Swertia japonica extract, Gentiana scabra root extract, Paeonia lactiflora root extract, 1,2-pentanediol, Centella asiatica extract, Artemisia capillaris extract, Panax ginseng root extract, Dendrobium officinale extract, and Ginkgo biloba leaf extract, with a total addition amount of 0.5%-3% of the total mass.

2. The anti-aging and deep wrinkle-removing firming lotion according to claim 1, characterized in that, The mass fraction of each component in the composite trace additive is as follows: 0.05-0.15% Acetyl hexapeptide-8, 0.01-0.05% Tripeptide-1, 0.01-0.05% Acetyl octapeptide-3, 0.02-0.08% Palmitoyl tripeptide-1, 0.01-0.05% Hexapeptide-9, 0.02-0.08% Palmitoyl tripeptide-5, 0.03-0.1% Palmitoyl pentapeptide-4, 0.02-0.08% Palmitoyl tetrapeptide-7, 0.05-0.15% Arginine / Lysine polypeptide, 0.1-0.3% Arginine, 0.4-0.7% Phenoxyethanol, 0.1-0.3% Capryloyl hydroxamic acid, 0.1-0.3% p-hydroxyacetophenone, 0.01-0.05% soluble collagen, 0.01-0.03% disodium EDTA, 0.05-0.15% glyceryl caprylate, 0.05-0.15% ethylhexylglycerin, 0.05-0.15% Swertia japonica extract, 0.05-0.15% Gentiana scabra root extract, 0.05-0.15% Paeonia lactiflora root extract, 0.5-1.5% 1,2-pentanediol, 0.1-0.3% Centella asiatica extract, 0.1-0.3% Artemisia capillaris extract, 0.1-0.3% Panax ginseng root extract, 0.1-0.3% Dendrobium officinale extract, and 0.1-0.3% Ginkgo biloba leaf extract.

3. The anti-aging and deep wrinkle-removing firming lotion according to claim 1, characterized in that, It contains the following components by mass fraction: The product contains: water balance, 10% Bifida ferment filtrate, 5% methyl propylene glycol, 2% polydimethylsiloxane / vinyl polydimethylsiloxane crosspolymer, 3% aminobutyric acid, 3% butylene glycol, 3% glycerol, 2% polysorbate-20, 1% hydrolyzed collagen, 1% Euglena polysaccharide, 2% sorbitan lauryl ester, 0.5% 1,2-hexanediol, 2% propylene glycol, 1% lauryl ether-25, 1% lauryl ether-3, 1% tetrahydromethylpyrimidine carboxylic acid, 0.4% polyacrylate crosspolymer-6, 0.2% hydroxyethyl cellulose, 0.1% sodium hyaluronate, 3% hydroxypropyl tetrahydropyrantriol, 3% Dalbergia odorifera bark extract, and 5% tomato extract. The total amount of the composite trace additive component is 1.5%.

4. The anti-aging and deep wrinkle-removing firming lotion according to claim 1, characterized in that, The preparation method of the tomato extract is as follows: Take fresh tomatoes, homogenize and crush them, add 5-10 times their weight of ethanol aqueous solution, reflux and extract at 40-60℃ for 2-4 hours, filter, concentrate the filtrate under reduced pressure until there is no alcohol taste, and the tomato extract is obtained.

5. The anti-aging and deep wrinkle-removing firming lotion according to claim 1, characterized in that, The preparation method of the Dalbergia odorifera bark extract is as follows: Take dried rosewood bark, crush it, add 10-15 times its weight of propylene glycol aqueous solution, extract at 50-70℃ for 3-5 hours, filter, and the filtrate is obtained.

6. The anti-aging and deep wrinkle-removing firming lotion according to claim 1, characterized in that, The extracts of Japanese swert, gentian root, peony root, centella asiatica, artemisia capillaris, ginseng root, dendrobium officinale, and ginkgo leaf are extracts obtained by extracting, filtering, and concentrating their respective dried raw materials with water or alcohol-water solutions.

7. A method for preparing the anti-aging and deep wrinkle-removing firming lotion according to any one of claims 1-6, characterized in that, Includes the following steps: S1. Take the amount of deionized water in the formula and add it to the aqueous phase pot. While stirring, slowly add polyacrylate cross-linked polymer-6 and hydroxyethyl cellulose. After dispersing evenly, add aminobutyric acid, butanediol, glycerol, propylene glycol, 1,2-pentanediol and disodium EDTA. Heat to 75-80℃ and stir evenly to obtain the aqueous phase. Keep it warm for later use. S2. Take the prescribed amounts of methyl propylene glycol, polydimethylsiloxane / vinyl polydimethylsiloxane cross-linked polymer, sorbitan laurate, lauryl alcohol polyether-25, and lauryl alcohol polyether-3 and add them to the oil phase pot. Heat to 75-80℃, stir evenly, and keep the oil phase warm for later use. S3. Slowly pump the oil phase into the aqueous phase and homogenize at high speed for 5-10 minutes to form a colostrum; S4. Slowly cool the colostrum to 45-50℃, then add the following in sequence: Bifida ferment filtrate, hydrolyzed collagen, Euglena polysaccharide, tetrahydromethylpyrimidine carboxylic acid, sodium hyaluronate, hydroxypropyl tetrahydropyrantriol, Dalbergia odorifera bark extract, tomato extract, polysorbate-20, and the complex trace additives. Stir well. S5. Continue cooling to 35-40℃, add pH adjuster (such as arginine) to adjust pH to 5.5-6.5, add preservatives phenoxyethanol, capryloyl hydroxamic acid, p-hydroxyacetophenone, glyceryl caprylate, ethylhexylglycerin and antioxidants, stir evenly, filter and discharge, fill into bottles to obtain the final product.

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