Pharmaceutical combination compositions, formulations, and methods of making and using same for treating herpes zoster

Abstract

The application discloses a medicine compound composition for treating herpes zoster, a preparation and a preparation and use method, and belongs to the technical field of medicines. The composition is combined by a formula A and a formula B, and a new raw material combination mode is used to effectively treat herpes zoster. The medicine compound preparation for treating herpes zoster is non-toxic, has a quick effect, is less and precise in use, has a high cure rate, and has a good stability.

Description

Technical Field

[0001] This invention belongs to the field of pharmaceutical technology, specifically relating to a compound pharmaceutical composition, preparation, and method of preparation and use for treating herpes zoster. Background Technology

[0002] Shingles is caused by the varicella-zoster virus (VZV). VZV is now named human herpesvirus type 3 (HHV-3). This virus is brick-shaped with a symmetrical capsid containing a double-stranded DNA molecule. VZV has weak resistance to the external environment and quickly loses its activity within a dried scab. Children immune to this virus develop chickenpox after infection. Some infected individuals become carriers without developing symptoms. Due to the virus's neurotropic properties, it can remain latent in the neurons of the dorsal root ganglia of the spinal cord for a long time after infection. When resistance is low, or during fatigue, infection, colds, fever, anger, or other stressful events, the virus can regrow, multiply, and migrate along nerve fibers to the skin, causing severe inflammation of the affected nerves and skin. The rash is generally unilateral and distributed along nerve segments, consisting of clustered vesicles, and accompanied by pain; the older the patient, the more severe the neuralgia. This disease is known in modern medicine as herpes zoster, and in folk medicine as shingles, snake-like sores, shingles, flying snake, etc.

[0003] Herpes zoster, known in Traditional Chinese Medicine as "snake-like sores," is an acute herpetic skin disease characterized by clusters of painful, burning blisters on the skin. Because of the numerous, clustered erythematous blisters on the skin, often appearing around the waist, it is also called "waist-encircling fire rash," "fire-belted blisters," or "snake rash." Its etiology and pathogenesis include emotional distress leading to liver qi stagnation, which over time transforms into fire; or improper diet causing spleen dysfunction, resulting in internal dampness and heat, which, combined with external pathogenic factors, leads to the accumulation of damp-heat and fire toxins in the skin. The pathogenic factors are damp toxins and fire toxins. The disease primarily affects the chest and waist, but can also spread to the face and lower limbs. Initially, it is often attributed to damp-heat in the liver and gallbladder or spleen meridian. Treatment focuses on clearing heat, resolving dampness, detoxifying, and purging fire.

[0004] Shingles rash typically occurs on one side of the body, presenting as painful, clustered blisters distributed along the peripheral nerve pathways, not crossing the midline of the body. It can occur on the face, neck, chest, abdomen, and limbs. In reality, shingles is a common condition that significantly impacts physical health and daily life.

[0005] Currently, numerous treatment methods exist in medical institutions and private settings, but for patients experiencing severe pain in the early to mid-stages of shingles, a single, effective treatment method is lacking. This leads to many patients suffering from postherpetic neuralgia, causing significant harm to their physical and mental health, financial losses, and long-term hospital visits, thus wasting medical resources. Furthermore, the treatment of postherpetic neuralgia exacerbates the harm and financial burden on patients, and also increases the drain on medical insurance funds. Therefore, improving the cure rate of shingles is a matter of great concern.

[0006] There are various treatments, methods, and medications available in medical institutions for shingles, but the results are often unsatisfactory. Summary of the Invention

[0007] The primary objective of this invention is to provide a compound pharmaceutical composition for treating shingles, wherein the composition achieves an effective treatment effect by combining ingredients A and B in a novel way.

[0008] The second objective of this invention is to provide a compound drug preparation for treating herpes zoster, which is non-toxic, fast-acting, requires less medication and is precise, has a high cure rate and good stability.

[0009] This invention is achieved through the following technical solution:

[0010] A pharmaceutical compound composition for treating herpes zoster, said pharmaceutical compound composition being used in combination with formula A and formula B; based on 20 mL of mixture / formula:

[0011] Formula A is composed of the following parts by weight of raw materials:

[0012] Lidocaine hydrochloride injection 5mL, vitamin B12 injection 3mL, vitamin B1 injection 2mL, ribavirin injection 4mL, prednisolone acetate injection 2mL and water for injection 4mL.

[0013] Formula B is composed of the following parts by weight of raw materials:

[0014] Lidocaine hydrochloride injection 2mL, vitamin B12 injection 3mL, vitamin B1 injection 2mL, ribavirin injection 4mL, dexamethasone injection 2mL, and water for injection 7mL.

[0015] Pharmacological effects:

[0016] 1. Lidocaine Hydrochloride Injection, English name: MLidocaine Hydrochloride Injection. Chinese Pinyin name: Yansuan MLiduokayin Zhusheye. Main ingredient: Lidocaine hydrochloride. Its chemical name is: N-(dichloroxylyl)-2-(diethylamino)acetamide hydrochloride monohydrate. Molecular formula: C 14 H 22 N 20 ·HCML·H 20 Molecular weight: 288.82. This product is a colorless, clear liquid. This product is an amide-type local anesthetic. After absorption into the bloodstream or intravenous administration, it has a significant biphasic effect on the central nervous system, with no prodromal excitation. At low blood concentrations, it produces analgesia, drowsiness, and an increased pain threshold. As the dose increases, the effect or toxicity intensifies. At sub-toxic blood concentrations, it has an anticonvulsant effect. When the blood concentration exceeds 5 mg / mL... -1 Seizures may occur. At low doses, this product can promote intracellular K+ in cardiomyocytes. + It effluxes, reducing myocardial automaticity and thus having an anti-ventricular arrhythmic effect. At therapeutic doses, it has no significant effect on myocardial cell electrical activity, atrioventricular conduction, or myocardial contractility. Further increases in blood concentration can slow cardiac conduction velocity, cause atrioventricular block, inhibit myocardial contractility, and decrease cardiac output. After injection, it distributes rapidly and widely through tissues, crossing the blood-brain barrier and placenta. It has high anesthetic potency, rapid onset, and strong diffusion; local elimination takes approximately 2 hours, and the addition of adrenaline can prolong its duration of action. Most of it is first degraded by hepatic microenzymes into the deethylated intermediate metabolite monoethylglycine-xylene, which still retains local anesthetic activity and has increased toxicity. It is then hydrolyzed by amidases and excreted in the urine; approximately 10% of the dose is excreted unchanged, with a small amount appearing in bile. This product is a local anesthetic and antiarrhythmic drug. It is mainly used for infiltration anesthesia, epidural anesthesia, and surface anesthesia, including mucosal anesthesia during thoracoscopic or laparoscopic surgery, and for nerve conduction block. This product can also be used for premature ventricular contractions and ventricular tachycardia after acute myocardial infarction, as well as for ventricular arrhythmias caused by digitalis poisoning, cardiac surgery, and cardiac catheterization. This product is generally ineffective for supraventricular arrhythmias.

[0017] 2. Vitamin B12 Injection. English name: Vitamin B12 Injection. Pinyin name: WeishengsuB12Zhusheye. Main ingredient: Vitamin B12. Its chemical name is: Coα-[α-(5,6-dimethylbenzimidazolyl)]-Coβ-cyanocobalaminamide. Molecular formula: C 63 H 88 CoN 14 O 14P. Molecular weight: 1355.38. This product is a clear, pink to red liquid, odorless and tasteless. It is an anti-anemia drug. Vitamin B12 participates in methyl conversion and folic acid metabolism in the body, promoting the conversion of 5-methyltetrahydrofolate to tetrahydrofolate. Deficiency leads to impaired DNA synthesis and affects the maturation of red blood cells. This product also promotes the conversion of methylmalonic acid to succinic acid, participating in the tricarboxylic acid cycle. This effect is related to the synthesis of myelin lipids and the maintenance of the integrity of myelinated nerve fibers; the neurological damage caused by vitamin B12 deficiency may be related to this. It is rapidly and completely absorbed after injection, reaching peak plasma concentration in about 1 hour; it is widely distributed in the body, but mainly stored in the liver, with a total adult storage of 4-5 mg; most of it is excreted by the kidneys within 8 hours, with higher doses resulting in greater excretion. It is mainly used for megaloblastic anemia caused by intrinsic factor deficiency, and can also be used as an adjunct treatment for subacute combined degenerative neurological diseases, such as neuritis.

[0018] 3. Vitamin B1 injection, chemical name: 4-methyl-3-[(2-methyl-4-amino-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)thiazolonium hydrochloride. Molecular formula: C 12 H 17 ClN4OS·HCl. Molecular weight: 337.27. This product is a colorless, clear liquid. It is suitable for the treatment of beriberi or Wernicke's encephalopathy caused by vitamin B1 deficiency. It can also be used as an adjunct treatment for peripheral neuritis and indigestion caused by vitamin B1 deficiency. This product is easily decomposed in alkaline solutions and is prone to deterioration when combined with alkaline drugs such as sodium bicarbonate and sodium citrate. This product is a vitamin. In the body, it combines with pyrophosphate to form coenzyme. It participates in the oxidative decarboxylation reaction of pyruvate and α-ketoglutarate in carbohydrate metabolism and is essential for carbohydrate metabolism. In case of deficiency, oxidation is inhibited, forming pyruvate, lactic acid accumulates, and the body's energy supply is affected. Its symptoms are mainly manifested in the nervous and cardiovascular systems, resulting in polyneuritis affecting both sensory and motor nerves, manifested as paresthesia, neuralgia, weakness in the limbs, as well as muscle soreness and atrophy. In terms of cardiovascular function, increased acetone and lactic acid in the blood cause dilation of small arteries, a decrease in diastolic blood pressure, and myocardial metabolic disorders, thus easily leading to symptoms of heart failure such as palpitations, shortness of breath, chest tightness, cardiac hypertrophy, hepatic and pulmonary congestion, and peripheral edema. In terms of the digestive system, symptoms include decreased appetite leading to weakness and weight loss. Intramuscular injection results in rapid absorption, widespread distribution throughout the body, no accumulation, hepatic metabolism, and renal excretion; the half-life (T1 / 2) is 0.35 hours.

[0019] 4. Ribavirin Injection, chemical name: 1-β-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide. Molecular formula: C8H 12N4O5 molecular weight: 244.21. This product is a colorless, clear liquid. Antiviral drug. Used for viral pneumonia and bronchitis caused by respiratory syncytial virus (RSV). Specification: 2mL: 100mg. This product has an antagonistic effect when used concurrently with zidovudine, as it inhibits the conversion of zidovudine to its active form, zidovudine phosphate. Pharmacologically, it is a broad-spectrum antiviral drug. In vitro, it inhibits the growth of various viruses, including RSV, influenza virus, hepatitis A virus, and adenovirus, although the mechanism is not fully understood. This product does not alter viral adsorption, invasion, or uncoating, nor does it induce interferon production. After entering virus-infected cells, the drug rapidly phosphorylates, and its product acts as a competitive inhibitor of viral synthases, inhibiting inosine monophosphate dehydrogenase, influenza virus RNA polymerase, and mRNA guanylate transferase, thereby reducing intracellular guanosine triphosphate, impairing viral RNA and protein synthesis, and suppressing viral replication and transmission. It may also have immunomodulatory and neutralizing antibody effects against RSV.

[0020] 5. Prednisolone acetate injection is indicated primarily for allergic and autoimmune inflammatory diseases. It is currently widely used for active rheumatism, rheumatoid arthritis, lupus erythematosus, severe bronchial asthma, nephrotic syndrome, thrombocytopenic purpura, granulocytopenia, various adrenal insufficiency syndromes, severe dermatitis, acute leukemia, etc., and is also used for the comprehensive treatment of certain infections. The main ingredient is prednisolone acetate. Excipients include Tween-80, CMC-Na, sodium chloride, sodium thimerosal, and water for injection. Chemical name: 11β,17α,21-trihydroxypregn-1,4-diene-3,20-dione-21-acetate. This product is a suspension of fine particles; after standing, the fine particles settle, and after shaking, a uniform milky white suspension is formed. Specification: 5mL: 0.125g. This product is an adrenocortical hormone. It possesses multiple pharmacological effects, including anti-inflammatory, anti-allergic, and immunosuppressive effects. 1. Anti-inflammatory effect: Glucocorticoids reduce and prevent tissue responses to inflammation, thereby alleviating inflammatory manifestations. 2. Immunosuppressive effect: It prevents or inhibits cell-mediated immune responses, delayed allergic reactions, and reduces the spread of primary immune responses. 3. Antitoxic and anti-shock effects: Glucocorticoids can counteract the stimulatory response of bacterial endotoxins to the body, reduce cell damage, and play a protective role; clinically, it is also commonly used in the treatment of severe shock, especially toxic shock. Intramuscular injection results in slow absorption. In the blood, most of the product binds to plasma proteins; free and conjugated metabolites are excreted in the urine, a portion is excreted unchanged, and a small portion may be excreted in breast milk.

[0021] 6. Dexamethasone Injection. The main ingredient of this product is dexamethasone acetate. Its chemical name is: 16α-methyl-11β,17α,21-trihydroxy-9α-fluoropregnane-1,4-diene-3,20-dione-21-acetate. Molecular formula: C 24H31FO6. Molecular weight: 434.50. This product is a suspension of fine particles. After standing, the fine particles settle, and after shaking, a uniform milky white suspension is formed. It is an adrenocortical hormone with more significant anti-inflammatory, anti-allergic, and anti-shock effects than prednisone, while having very mild effects on water and sodium retention and promoting potassium excretion, and a stronger inhibitory effect on the pituitary-adrenal axis. 1) Anti-inflammatory effect: This product can reduce and prevent tissue responses to inflammation, thereby alleviating the manifestations of inflammation. The hormone inhibits the accumulation of inflammatory cells, including macrophages and leukocytes, at the site of inflammation, and inhibits phagocytosis, the release of lysosomal enzymes, and the synthesis and release of inflammatory chemical mediators. It can reduce and prevent tissue responses to inflammation, thereby alleviating the manifestations of inflammation. 2) Immunosuppressive effects: This includes preventing or inhibiting cell-mediated immune responses, delayed allergic reactions, reducing the number of T lymphocytes, monocytes, and eosinophils, decreasing the binding capacity of immunoglobulins to cell surface receptors, and inhibiting the synthesis and release of interleukins, thereby reducing the transformation of T lymphocytes into lymphoblasts and mitigating the spread of the primary immune response. It can reduce the passage of immune complexes across the basement membrane and decrease the concentration of complement components and immunoglobulins. Peak plasma concentrations are reached 8 hours after intramuscular injection of dexamethasone acetate. Its plasma protein binding rate is lower than that of other corticosteroids. This drug is mainly used for allergic and autoimmune inflammatory diseases, such as connective tissue diseases, rheumatoid arthritis, severe bronchial asthma, allergic diseases such as dermatitis, ulcerative colitis, acute leukemia, and malignant lymphoma.

[0022] 7. Water for Injection: Main component: Sodium chloride. Molecular formula: NaCl. Molecular weight: 58.44. This product is a colorless, clear liquid with a slightly salty taste. Specification: 0.9% (2000mL: 18g, 3000mL: 27g). Sodium chloride enters the bloodstream directly after intravenous injection and is widely distributed in the body, but mainly exists in the extracellular fluid. Both sodium and chloride ions can be filtered by the glomeruli and partially reabsorbed by the renal tubules. It is excreted by the kidneys in the urine, with only a small portion excreted in sweat.

[0023] A combination pharmaceutical preparation for treating herpes zoster, the preparation comprising the aforementioned combination pharmaceutical composition for treating herpes zoster.

[0024] A method for preparing a compound drug formulation for treating herpes zoster includes the following steps:

[0025] S1. Select the raw materials in Formula A according to the corresponding mass fractions: lidocaine hydrochloride injection, vitamin B12 injection, vitamin B1 injection, ribavirin injection, prednisolone acetate injection and water for injection. Mix them well and divide them into two equal portions of 10 mL each for later use, for a total of 20 mL. This completes the preparation.

[0026] S2. Select the raw materials in formula B according to the corresponding mass proportions: lidocaine hydrochloride injection, vitamin B12 injection, vitamin B1 injection, ribavirin injection, dexamethasone injection and water for injection. Mix them well and divide them into two equal portions of 10 mL each, for a total of 20 mL, to complete the preparation.

[0027] Preferably, the compound drug preparation is an oral preparation.

[0028] A method of using a compound drug preparation for treating herpes zoster, wherein the compound drug preparation is used in combination by injection into the selected damaged nerve root on the affected side and acupoints on the body.

[0029] The specific method of use for the above-mentioned compound preparation of the drug is as follows:

[0030] Formula A is used for the selected damaged nerve root block injection (including 6 nerve root sites);

[0031] Formula B is used for injection at acupoints on the body.

[0032] I. Patients with neck, head, face, and upper limb areas:

[0033] First, injection is performed at the selected damaged nerve root site using method A; then, acupoint injection is performed using method B, as follows:

[0034] Option A: First select C3, C4, C5, C6, C7, T1

[0035] Injection Method: To ensure accurate injection, draw a vertical line along the midline of the C3-C7 and T1 vertebral bodies. Draw another vertical line 1.2 cm lateral to the midline on the affected side. Draw a horizontal line between the two vertebral bodies, intersecting the lateral lines to form a cross. Use two 10mL disposable sterile syringes, prepare the dosage according to formula A, and draw 10mL of the mixture from each syringe for later use, for a total of 20mL. Change to a No. 5 needle and shake the mixture well before injection. Perform routine disinfection at the six selected injection sites. Insert the needle at the cross-shaped point, at a 90° angle to the skin, for approximately 1-1.5cm, then further obliquely upwards and inwards at a 5°-15° angle to the spine. During injection, if the patient experiences a tingling, numb, or distending sensation, aspirate the syringe. If no blood return is observed, slowly inject 3.3mL of the mixture into each site. Aspirate the syringe multiple times during the injection process to prevent the medication from entering the blood vessels. Administer once daily. (10mL for three nerve root sites) After injection, disinfect and cover with sterile gauze for fixation.

[0036] Acupoint injection:

[0037] Formula B: Selected acupoints: (① Taichong, ② Sanyinjiao, ③ Zusanli, ④ Xuehai, ⑤ Quchi, ⑥ Hegu, ⑦ Fengchi, ⑧ Jianjing, ⑨ Dazhui, ⑩ Feishu) The Liver Shu point (Ganshu) contains a total of 11 acupoints and 21 injection points.

[0038] Injection method: A total of 11 acupoints and 21 injection points are applied to the neck, face, and upper limbs. Using two 10mL disposable sterile syringes, draw 10mL of the mixture according to the dosage prepared in Formula B (total 20mL). Change to a No. 5 needle and perform routine skin disinfection before injection. Inject 0.8–1mL of the mixture per acupoint per injection. After needle insertion, perform lifting, thrusting, and rotating techniques. Once a tingling, numb, and distending sensation is felt, and no blood reflux is observed when aspirating from the syringe, the injection is complete. Administer once daily.

[0039] Note: For primary eye symptoms, add the temple acupoint; for primary ear symptoms, add the Tinggong acupoint.

[0040] II. Patients with chest and abdominal pain:

[0041] First, injection is performed at the selected damaged nerve root site using method A; then, acupoint injection is performed using method B, as follows:

[0042] Method A: Select the affected side of the thoracolumbar spine

[0043] To ensure precise injection, six sites were selected based on the location of the lesion and the upper and lower limits of the pain area, including the thoracic and thoracolumbar vertebrae on the affected side. A vertical line was drawn in the midline of the selected vertebral body containing the damaged nerve root, and another vertical line was drawn 1.5 cm lateral to the midline. Horizontal lines were drawn in the midline of the two vertebral bodies, intersecting the lateral lines to form a cross. The injection sites were routinely disinfected. Using two 10mL disposable sterile syringes, 10mL of the mixture was drawn from each syringe according to formula A, for a total of 20mL. A No. 5 needle was used, and the mixture was shaken well before injection. After routine disinfection of the six selected injection sites, the needle was inserted at the intersection of the six sites, at a 90° angle to the skin, approximately 1–1.5 cm deep, then angled upwards and inwards towards the spine at a 5°–15° angle. During injection, if the patient experienced a tingling, numb, or distending sensation, the syringe was aspirated. If no blood flow was observed, 3.3mL of the mixture was slowly injected into each site. The syringe was aspirated multiple times during the injection process to prevent the medication from entering a blood vessel. (Inject 10mL into three nerve root sites) After injection, disinfect, cover and fix with sterile gauze, once a day.

[0044] Acupoint injection:

[0045] Formula B: Select basic acupoints: (① Taichong, ② Sanyinjiao, ③ Zusanli, ④ Xuehai, ⑤ Quchi, ⑥ Fengchi, ⑦ Dazhui, ⑧ Feishu, ⑨ Ganshu.) A total of 9 acupoints and 17 injection points.

[0046] Injection Method: For affected areas below the chest and abdomen, use basic acupoints for injection, totaling 9 acupoints and 17 injection points. Use two 10mL disposable sterile syringes to draw 10mL of the mixture (total 20mL) according to the dosage prepared in Formula B. Change to a No. 5 needle and perform routine skin disinfection before injection. Inject 1-1.2mL of the mixture per acupoint per injection. After needle insertion, perform lifting, thrusting, and rotating techniques. Once a tingling, numb, and distending sensation is felt, and there is no blood backflow when aspirating from the syringe, the injection is complete. Administer once daily.

[0047] III. Patients with problems in the buttocks, perineum, and lower extremities:

[0048] First, injection is performed at the selected damaged nerve root site using method A; then, acupoint injection is performed using method B, specifically as follows:

[0049] Option A: Select lumbar vertebrae 3, 4, and 5, and sacral vertebrae 1, 2, and 3.

[0050] To ensure accurate injection, select L3, L4, L5, and S1, L2, and S3. Draw a vertical line along the midline of the vertebral body on the selected affected side of the lumbar and sacral vertebrae, and another vertical line 1.5 cm lateral to the midline. Draw horizontal lines along the midline of the two vertebral bodies, intersecting the lateral lines to form a cross. Use two 10mL disposable sterile syringes, prepare the dosage according to formula A, and draw 10mL of the mixture from each syringe (total 20mL). Change to a No. 5 needle and shake the mixture well before injection. Perform routine disinfection at the six selected injection sites. Insert the needle at the intersection of the lines, at a 90° angle to the skin, for approximately 1–1.5 cm, then further obliquely upwards and inwards at a 5°–15° angle to the spine. During injection, if the patient experiences a tingling, numb, or distending sensation, aspirate the syringe. If no blood return is observed, slowly inject 3.3mL of the mixture at each site. Aspirate the syringe multiple times during the injection process to prevent the medication from entering a blood vessel. (10mL is injected into three nerve root sites).

[0051] Insert the needle perpendicularly into the S1, 2, and 3 sacral vertebrae. When you feel a hollow sensation, it indicates that the needle has entered the sacral foramen. Withdraw the needle slightly; if no blood flows back into the syringe, slowly inject 3.3 mL of the mixture into the S1, 2, and 3 sacral foramina. During the injection, aspirate the syringe multiple times to prevent the medication from entering a blood vessel. (10 mL injected into three sacral foramina). After injection, disinfect the syringe, cover, and secure with sterile gauze. Administer once daily.

[0052] Formula B: Selection of basic acupoints: Injection using basic acupoints, a total of 9 acupoints, 17 injection points (① Taichong, ② Sanyinjiao, ③ Zusanli, ④ Xuehai, ⑤ Quchi, ⑥ Fengchi, ⑦ Dazhui, ⑧ Feishu, ⑨ Ganshu).

[0053] Injection Method: For the affected areas of the buttocks, perineum, and lower limbs, use basic acupoints for injection, totaling 9 acupoints and 17 injection points. Use two 10mL disposable sterile syringes to draw 10mL of the mixture (total 20mL) according to the dosage prepared in Formula B. Change to a No. 5 needle and perform routine skin disinfection before injection. Inject 1-1.2mL of the mixture per acupoint per injection. After needle insertion, perform lifting, thrusting, and rotating techniques. Once a tingling, numb, and distending sensation is felt, and there is no blood backflow when aspirating from the syringe, the injection is complete. Administer once daily.

[0054] The inventors of this application suggest that after treatment with the above-mentioned preparation, patients should only take Banlangen granules, 2 sachets / 3 times, for 5 consecutive days.

[0055] Note: After disinfection, all injection sites should be covered and secured with sterile gauze.

[0056] Compared with the prior art, the present invention has at least the following technical effects:

[0057] (I) This invention provides a compound drug composition for treating herpes zoster. The composition achieves the effect of effectively treating herpes zoster by combining formula A and formula B in a novel way of combining raw materials.

[0058] (ii) The compound preparation for treating herpes zoster is non-toxic, fast-acting, requires less medication and is precise, has a high cure rate and good stability.

[0059] This compound preparation for treating shingles combines traditional Chinese medicine preparations, which together exert an antiviral effect.

[0060] (III) The combination of compound solution A and compound solution B in this application, when applied in clinical practice, has completely reversed the defects and deficiencies of the current medical institutions in treating herpes zoster, avoided the occurrence of postherpetic neuralgia, greatly reduced the suffering and economic losses of patients, and also prevented patients from suffering from chronic diseases. At the same time, it has greatly reduced the loss of national medical insurance funds and greatly reduced the waste of medical resources.

[0061] This drug compound composition has the following advantages:

[0062] 1. Pain relief effect is immediate;

[0063] 2. It repairs damaged nerve root tissue and surrounding tissues quickly;

[0064] 3. Short treatment cycle and high cure rate;

[0065] 4. It can effectively prevent postherpetic neuralgia, facial paralysis, trigeminal neuralgia, deafness and tinnitus, and optic nerve damage;

[0066] 5. Suitable for patients with shingles in different locations;

[0067] 6. It quickly reduces erythema, inflammatory exudate, and edema caused by herpes at the lesion site;

[0068] 7. It has good antiviral effects;

[0069] 8. Most patients in the early and middle stages can avoid the pain caused by treatments such as local bloodletting and cupping;

[0070] 9. It can effectively alleviate patients' pain, reduce the number of visits, greatly reduce the waste of medical resources, and significantly reduce treatment costs.

[0071] (IV) Advantages of using acupoint injection therapy for the above-mentioned compound drug composition: 1. Taichong (LR3): Foot Jueyin Liver Meridian – Function: Soothes the liver and regulates qi, extinguishes wind and clears heat; 2. Sanyinjiao (SP6): Foot Taiyin Spleen Meridian – Function: Harmonizes the stomach and strengthens the spleen, soothes the liver and benefits the kidneys, regulates menstruation and invigorates blood; 3. Zusanli (ST36): Foot Yangming Stomach Meridian – Function: Strengthens the spleen and stomach, regulates blood and qi, supports the body's resistance and eliminates pathogens; 4. Xuehai (SP10): Foot Taiyin Spleen Meridian – Function: Regulates menstruation and nourishes blood, dispels wind and clears heat; 5. Hegu (LI4): Hand Yangming Large Intestine Meridian – Function: Dispels wind, relieves pain, unblocks meridians and invigorates collaterals; 6. Quchi (LI11): Hand Yangming Large Intestine Meridian – Function: Dispels wind, relieves pain, unblocks meridians and invigorates collaterals; 7. Fengchi (GB20): Gallbladder Meridian of Foot-Shaoyang – Function: Clears heat and dispels wind, harmonizes blood; 8. Dazhui (GV14): Governing Vessel – Function: Dispels wind and releases the exterior, invigorates Yang; 9. Feishu (BL13): Bladder Meridian of Foot-Taiyang – Function: Clears heat and regulates blood, promotes Qi circulation and lung function; 10. Ganshu (BL18): Bladder Meridian of Foot-Taiyang – Function: Soothes the liver and gallbladder, clears heat and brightens the eyes; 11. Taiyang (EX-HN5): Extra point – Function: Dispels wind and clears heat, unblocks meridians and relieves pain; 12. Tinggong (SI19): Small Intestine Meridian of Hand-Taiyang – Function: Calms the mind and invigorates the meridians, thereby opening the orifices.

[0072] The selected acupoints and meridians are the Liver Meridian, Gallbladder Meridian, Spleen Meridian, Stomach Meridian, Small Intestine Meridian, Large Intestine Meridian, and Extra Points on the Governing Vessel. Traditional Chinese medicine believes that the pathogenesis of this disease is "emotional distress, stagnation of Liver Qi, which over time transforms into fire; or irregular eating habits, impaired Spleen function, internal generation of dampness and turbidity, which stagnates and transforms into heat; internal accumulation of damp-heat, further aggravated by external pathogenic factors, leading to the accumulation of damp-heat and fire toxins in the skin." By needling the aforementioned acupoints and meridians, the synergistic effects of these meridians are stimulated, achieving the goals of unblocking the meridians, soothing the Liver and Gallbladder, strengthening the Spleen and eliminating dampness, and detoxifying and clearing heat, thus achieving the therapeutic effect. Detailed Implementation

[0073] The embodiments of the present invention will be described in detail below with reference to the examples. However, those skilled in the art will understand that the following examples are only for illustrating the present invention and should not be regarded as limiting the scope of the present invention. Specific conditions not specified in the examples shall be carried out according to conventional conditions or conditions recommended by the manufacturer. Reagents or instruments whose manufacturers are not specified are all conventional products that can be purchased commercially.

[0074] One specific embodiment of the present invention is as follows:

[0075] Drug combination formula A:

[0076]

[0077]

[0078] Drug combination formula B:

[0079]

[0080] Note: For the portion of water for injection mentioned above, an equal amount of physiological saline can also be used in actual applications.

[0081] Example 1:

[0082] A pharmaceutical compound composition for treating herpes zoster, said pharmaceutical compound composition being used in combination of formula A and formula B;

[0083] Based on a 20 mL mixture / cubic meter:

[0084] Formula A is composed of the following parts by weight of raw materials:

[0085] Lidocaine hydrochloride injection 5mL, vitamin B12 injection 3mL, vitamin B1 injection 2mL, ribavirin injection 4mL, prednisolone acetate injection 2mL and water for injection 4mL.

[0086] Formula B is composed of the following parts by weight of raw materials:

[0087] Lidocaine hydrochloride injection 2mL, vitamin B12 injection 3mL, vitamin B1 injection 2mL, ribavirin injection 4mL, dexamethasone injection 2mL, and water for injection 7mL.

[0088] A method for preparing a compound drug formulation for treating herpes zoster includes the following steps:

[0089] S1. Select the raw materials in formula A according to the corresponding mass fractions: lidocaine hydrochloride injection, vitamin B12 injection, vitamin B1 injection, ribavirin injection, prednisolone acetate injection and water for injection, mix them well, divide them into 2 equal portions for later use, and complete the preparation.

[0090] S2. Select the raw materials in formula B according to the corresponding mass proportions: lidocaine hydrochloride injection, vitamin B12 injection, ribavirin injection, dexamethasone injection and water for injection, mix them well, divide them into 2 equal portions for later use, and complete the preparation.

[0091] The compound drug preparation is for internal use.

[0092] A method of using a compound drug preparation for treating herpes zoster, wherein the compound drug preparation is administered via nerve root and acupoint injection.

[0093] Clinical Case:

[0094] Clinical Treatment Case (I) (7 cases in total)

[0095] Patient: Liu, male, 43 years old, XX Community, Chaoyang District, date: December 24, 2023.

[0096] Chief complaint: General weakness, itchy and painful head for 5 days, worsening intermittently at night, and herpes for 3 days.

[0097] Physical examination: The patient appeared distressed, and patchy erythema, papules and vesicles, clustered vesicles, and some of them ruptured were visible on the right side of the head, face and around the eyes.

[0098] Past medical history: No history of drug allergies or infectious diseases.

[0099] Diagnosis: Herpes zoster.

[0100] Treatment process: The patient assumes a supine or prone position. First, the required acupoints for injection are selected and marked (① Taichong, ② Sanyinjiao, ③ Zusanli, ④ Xuehai, ⑤ Hegu, ⑥ Quchi, ⑦ Fengchi, ⑧ Dazhui, ⑨ Jianjing, ⑩ Feishu). Liver Shu (BL18) sun).

[0101] Nerve root block injection method: Select cervical vertebrae C3, C4, C5, C6, C7, and thoracic vertebrae T1. To ensure injection accuracy, elevate the chest and arch the neck. Draw a vertical line in the midline of the C3-C7 and T1 vertebrae. Draw another vertical line 1.2 cm lateral to the midline on the affected side. Draw a horizontal line between the two vertebrae, intersecting the lateral lines to form a cross. Use two 10mL disposable sterile syringes, prepare the dosage according to formula A, and draw 10mL of the mixture from each syringe for later use, for a total of 20mL. Change to a No. 5 injection needle and shake the mixture well before injection. Routinely disinfect the six selected injection sites. Insert the needle at the intersection of the lines, at a 90° angle to the skin, about 1-1.5 cm deep, then obliquely upward and inward at a 5°-15° angle to the spine. During injection, if the patient experiences tingling, numbness, or distension, aspirate the syringe. If there is no blood return, slowly inject 3.3mL of the mixture at each site. During the injection, aspirate the syringe multiple times to prevent the medication from entering the blood vessels. (Inject 10mL into three nerve root sites.) After injection, disinfect the syringe, cover and secure with sterile gauze. Administer once daily for 5 consecutive days.

[0102] Selected acupoints: (① Taichong, ② Sanyinjiao, ③ Zusanli, ④ Xuehai, ⑤ Quchi, ⑥ Hegu, ⑦ Fengchi, ⑧ Jianjing, ⑨ Jianjing, ⑩ Feishu) Liver Shu (BL18) (Taiyang), a total of 12 acupoints and 23 injection points. Add Taiyang acupoint for main eye symptoms, and add Tinggong acupoint for main ear symptoms.

[0103] Acupoint injection method: Use two 10mL disposable sterile syringes to draw 10mL of the mixture according to the dosage prepared in Formula B (total 20mL), change to a No. 5 needle, and perform routine skin disinfection before injection. Each acupoint can be injected with 0.8-1mL of the mixture per injection. After needle insertion, perform lifting, thrusting, and rotating movements until a tingling, numb, and distending sensation is felt. Aspirate the syringe; if no blood reflux is observed, proceed with the injection. Disinfect the injection site after completion. Administer once daily for 5 consecutive days.

[0104] Doctor's instructions: During treatment, take only Banlangen granules, 2 sachets / time, 3 times a day for 5 consecutive days. Discontinue other medications for treating shingles. After completing the daily injections, take oral antiviral medication and neurotrophic drugs for 5 days, and apply acyclovir cream topically. Follow up if any discomfort occurs.

[0105] A follow-up phone call was made more than 10 days later, and the patient reported no discomfort.

[0106] Clinical Treatment Case (II)

[0107] Patient: Liu xx, Age: 60, Gender: Male, Address: Dongba XX Community, Date: January 5, 2018.

[0108] Chief complaint: Pain in the right shoulder and upper arm for about 10 days, described as needle-like radiating pain, worsening intermittently, with increased pain at night, and limited upper limb movement. Suspected to be caused by cervical spondylosis. Self-treatment with medication for cervical spondylosis and painkillers was initiated after 5 days with no effect and symptoms worsened, with nighttime pain preventing sleep. Patchy erythematous blisters appeared on the shoulder and upper arm, and the painful areas were too sensitive to touch.

[0109] Physical examination: Patchy erythema, papules, clustered vesicles, some of which ruptured and were painful to the touch were visible on the patient's right shoulder and the inner and outer sides of the upper arm.

[0110] Past medical history: Cervical spondylosis, hypertension, no history of drug allergies.

[0111] Diagnosis: Herpes zoster.

[0112] Treatment Process: The patient assumes a supine or prone position. The required acupoints for injection are first selected and marked (① Taichong, ② Sanyinjiao, ③ Zusanli, ④ Xuehai, ⑤ Hegu, ⑥ Quchi, ⑦ Fengchi, ⑧ Dazhui, ⑨ Jianjing, ⑩ Feishu). Liver Shu point).

[0113] Nerve root block injection method: Select cervical vertebrae C3, C4, C5, C6, C7, and thoracic vertebrae T1. To ensure injection accuracy, elevate the chest and arch the neck. Draw a horizontal line in the midline of the C3-C7 and T1 vertebrae. Draw a vertical line 1.2 cm lateral to the midline on the affected side. Draw a parallel line between the two vertebrae, intersecting the lateral lines to form a cross. Use two 10mL disposable sterile syringes, prepare the dosage according to formula A, and draw 10mL of the mixture into each syringe for later use, for a total of 20mL. Change to a No. 5 injection needle and shake the mixture well before injection. Routinely disinfect the six selected injection sites. Insert the needle at the intersection of the lines, at a 90° angle to the skin, for about 1-1.5 cm, then obliquely upward and inward at a 5°-15° angle to the spine. During injection, if the patient experiences tingling, numbness, or distension, aspirate the syringe. If there is no blood return, slowly inject 3.3mL of the mixture into each site. During the injection, the syringe should be aspirated multiple times to prevent the medication from entering the blood vessels. (10mL is injected into three nerve root sites.) After injection, disinfect the syringe, cover and secure it with sterile gauze, and repeat once daily for four consecutive days.

[0114] Acupoint injection:

[0115] Formula B: Selected acupoints: (① Taichong, ② Sanyinjiao, ③ Zusanli, ④ Xuehai, ⑤ Quchi, ⑥ Hegu, ⑦ Fengchi, ⑧ Jianjing, ⑨ Jianjing, ⑩ Feishu) The Liver Shu point (Ganshu) contains a total of 11 acupoints and 21 injection points.

[0116] Acupoint injection method: Use two 10mL disposable sterile syringes to draw 10mL of the mixture according to the dosage prepared in Formula B (total 20mL), change to a No. 5 needle, and perform routine skin disinfection before injection. Each acupoint can be injected with 0.8-1mL of the mixture per injection. After needle insertion, perform lifting, thrusting, and rotating movements until a tingling, numb, and distending sensation is felt. Aspirate the syringe; if no blood reflux is observed, proceed with the injection. Disinfect the injection site after completion. Administer once daily for four consecutive days.

[0117] Doctor's instructions: During treatment, take only Banlangen granules, 2 sachets / time, 3 times a day for 5 consecutive days. Discontinue other medications for treating shingles. After completing the daily injections, take oral antiviral medication and neurotrophic drugs for 5 days, and apply acyclovir cream topically. Follow up if any discomfort occurs.

[0118] A follow-up phone call was made more than 10 days later, and the patient reported no discomfort.

[0119] Clinical Treatment Case (III)

[0120] Patient: Ms. Chang, age: 55, gender: female. Address: XX Community, Dongba. Date: December 29, 2023.

[0121] Chief complaint: Three days ago, the patient experienced general weakness and sharp, needle-like pain in the right chest and abdomen, which occurred intermittently and worsened at night. The patient was unable to touch the painful area. Two days later, erythema and blisters appeared.

[0122] Physical examination: The patient had large patches of erythema, papules and vesicles, and clustered vesicles on the right side of the chest and abdomen to the periumbilical region, which were distributed in a band-like pattern and were painful to the touch.

[0123] Past medical history: Cervical spondylosis, no history of drug allergies.

[0124] Diagnosis: Herpes zoster.

[0125] Treatment process: The patient is placed in a supine or prone position. The required acupoints for injection are first selected and marked (① Taichong, ② Sanyinjiao, ③ Zusanli, ④ Xuehai, ⑤ Quchi, ⑥ Fengchi, ⑦ Dazhui, ⑧ Feishu, ⑨ Ganshu). A total of 9 acupoints and 17 injection points are involved.

[0126] Nerve root block injection method: Select T10-L3 based on the upper and lower limits of the pain area. To ensure injection accuracy, elevate and arch the chest and abdomen. Draw a vertical line in the midline of the T10-L3 vertebral body, and draw another vertical line 1.5 cm lateral to the midline on the affected side. Draw a horizontal line between the two vertebral bodies, intersecting the lateral lines to form a cross. Use two 10mL disposable sterile syringes, prepare the dosage according to formula A, and draw 10mL of the mixture from each syringe for later use, for a total of 20mL. Change to a No. 5 injection needle and shake the mixture well before injection. Routinely disinfect the six selected injection sites. Insert the needle at the intersection of the lines, at a 90° angle to the skin, about 1-1.5 cm deep, and then obliquely upward and inward at a 5°-15° angle to the spine. During injection, if the patient experiences tingling, numbness, or distension, aspirate the syringe. If there is no blood return, slowly inject 3.3mL of the mixture at each site. During the injection, aspirate the syringe multiple times to prevent the solution from entering the blood vessel. (Inject 10mL into three nerve root sites) After injection, disinfect, cover and secure with sterile gauze. Administer once daily for 3 consecutive days.

[0127] Acupoint injection:

[0128] Formula B: Selected acupoints: (① Taichong, ② Sanyinjiao, ③ Zusanli, ④ Xuehai, ⑤ Quchi, ⑥ Fengchi, ⑦ Dazhui, ⑧ Feishu, ⑨ Ganshu) a total of 9 acupoints and 17 injection points.

[0129] Acupoint injection method: Using two 10mL disposable sterile syringes, draw 10mL of the mixture according to the dosage prepared in Formula B (total 20mL). Change the syringe needles five times. Perform routine skin disinfection before injection. Inject 1.5mL into each of the four acupoints (Taichong and Ganshu). Divide the remaining injection points equally among the four injection points. After needle insertion, perform lifting, thrusting, and rotating movements until a tingling, numb, and distending sensation is felt. Aspirate the syringe; if no blood return is observed, proceed with the injection. Disinfect the injection site after completion. Administer once daily for three consecutive days.

[0130] Doctor's instructions: During treatment, take only Banlangen granules, 2 sachets / time, 3 times a day for 5 consecutive days. Discontinue other medications for treating shingles. After completing the daily injections, take oral antiviral medication and neurotrophic drugs for 5 days, and apply acyclovir cream topically. Follow up if any discomfort occurs.

[0131] A follow-up phone call was made more than 10 days later, and the patient reported no discomfort.

[0132] Clinical Treatment Case (IV)

[0133] Patient: Ms. Li, 86 years old, residing in XX Community, Shunyi District, on November 26, 2021.

[0134] Chief complaint: Right-sided back and abdominal pain for over 20 days, described as needle-like pain, paroxysmal exacerbation, and a burning sensation. Skin is tender to the touch, with erythema and blisters. Insomnia and poor appetite. Previously diagnosed with shingles at Shunyi District Hospital. Treated with antiviral drugs, painkillers, neurotrophic drugs, topical calamine lotion, and acyclovir cream, but after 7 days there was no improvement and symptoms worsened; presenting today.

[0135] Physical examination: Large patches of erythema, papules and vesicles, and clustered vesicles were visible on the patient's right back, abdomen, and periumbilical region, distributed in a band-like pattern. Some of these vesicles ruptured and were painful to the touch.

[0136] Past medical history: cervical spondylosis, lumbar spondylosis, hypertension, coronary heart disease, diabetes, no history of drug allergies.

[0137] Diagnosis: Herpes zoster.

[0138] Treatment process: The patient is placed in a supine or prone position. The required acupoints for injection are first selected and marked (① Taichong, ② Sanyinjiao, ③ Zusanli, ④ Xuehai, ⑤ Quchi, ⑥ Fengchi, ⑦ Dazhui, ⑧ Feishu, ⑨ Ganshu). A total of 9 acupoints and 17 injection points are involved.

[0139] Nerve root block injection method: Select T10-L3 vertebrae based on the upper and lower limits of the pain location. To ensure accurate injection site, elevate and arch the chest and abdomen. Draw a vertical line in the midline of the T10-L3 vertebral bodies, and draw another vertical line 1.5 cm lateral to the midline on the affected side. Draw a horizontal line between the two vertebral bodies, intersecting the lateral lines to form a cross. Use two 10mL disposable sterile syringes, prepare the dosage according to formula A, and draw 10mL of the mixture from each syringe for later use, for a total of 20mL. Change to a No. 5 injection needle and shake the mixture well before injection. Routinely disinfect the six selected injection sites. Insert the needle at the intersection of the crosses, at a 90° angle to the skin, about 1-1.5 cm deep, and then obliquely upward and inward at a 5°-15° angle to the spine. During injection, if the patient experiences tingling, numbness, or distension, aspirate the syringe. If there is no blood return, slowly inject 3.3mL of the mixture at each site. During the injection, aspirate the syringe multiple times to prevent the drug from entering the blood vessels. (Inject 10mL into three nerve root sites) After injection, disinfect, cover and secure with sterile gauze. Administer once daily for three consecutive days.

[0140] Acupoint injection:

[0141] Formula B: Select the marked acupoints: (① Taichong, ② Sanyinjiao, ③ Zusanli, ④ Xuehai, ⑤ Quchi, ⑥ Fengchi, ⑦ Dazhui, ⑧ Feishu, ⑨ Ganshu) a total of 9 acupoints and 17 injection points.

[0142] Acupoint injection method: Use two 10mL disposable sterile syringes to draw 10mL of the mixture according to the dosage prepared in Formula B, for a total of 20mL. Change to a No. 5 injection needle and perform routine skin disinfection before injection. Inject 1.5mL at each of the four injection points (Taichong and Ganshu), and divide the mixture equally at the remaining injection points. After inserting the needle, perform lifting, thrusting, and rotating movements until a tingling, numb, and distending sensation is felt. Aspirate the syringe; if no blood return is observed, proceed with the injection. Disinfect the injection site after completion. Administer once daily for three consecutive days.

[0143] Doctor's instructions: During treatment, take only Banlangen granules, 2 sachets / time, 3 times a day for 5 consecutive days. Discontinue other medications for shingles. After completing the daily injections, take oral antiviral medication and neurotrophic drugs for 5 days, and apply acyclovir cream topically. Consult a doctor if any discomfort occurs. Monitor blood sugar, blood pressure, and heart condition during treatment.

[0144] A follow-up phone call 15 days later revealed that the patient had no discomfort.

[0145] Clinical Treatment Case (5)

[0146] Patient: Jiang, male, 55 years old. Address: XX Community, Dongba, Chaoyang District. Date: April 6, 2018.

[0147] Chief complaint: Pain in the left chest, abdomen, and back for about 5 days, described as stabbing and radiating pain, which worsens intermittently, causing insomnia at night. The pain has intensified in the last 2 days, with erythema appearing on the left back, chest, and around the navel, making it difficult to touch.

[0148] Physical examination: Large patches of erythema and clusters of vesicles the size of soybeans were visible on the patient's left back, chest and upper abdomen, distributed in a band-like pattern, and were significantly painful to the touch.

[0149] Past medical history: Cervical spondylosis, hypertension. No history of drug allergies.

[0150] Diagnosis: Herpes zoster.

[0151] Treatment process: The patient is placed in a supine or prone position. The required acupoints for injection are first selected and marked (① Taichong, ② Sanyinjiao, ③ Zusanli, ④ Xuehai, ⑤ Quchi, ⑥ Fengchi, ⑦ Dazhui, ⑧ Feishu, ⑨ Ganshu). A total of 9 acupoints and 17 injection points are involved.

[0152] Nerve root block injection method: Select T9-L2 vertebrae based on the upper and lower limits of the pain location. To ensure precise injection site, elevate and arch the chest and abdomen. Draw a vertical line in the midline of the T9-L2 vertebral body, and another vertical line 1.5 cm lateral to the midline on the affected side. Draw a horizontal line between the two vertebral bodies, intersecting the lateral lines to form a cross. Use two 10mL disposable sterile syringes, prepare the dosage according to formula A, and draw 10mL of the mixture from each syringe for later use, for a total of 20mL. Change to a No. 5 injection needle and shake the mixture well before injection. Routinely disinfect the six selected injection sites. Insert the needle at the intersection of the crosses, at a 90° angle to the skin, about 1-1.5 cm deep, and then obliquely upward and inward at a 5°-15° angle to the spine. During injection, if the patient experiences tingling, numbness, or distension, aspirate the syringe. If there is no blood return, slowly inject 3.3mL of the mixture at each site. During the injection, aspirate the syringe multiple times to prevent the solution from entering the blood vessel. (Inject 10mL into three nerve root sites) After injection, disinfect, cover and secure with sterile gauze. Administer once daily for three consecutive days.

[0153] Acupoint injection:

[0154] Formula B: Select the marked acupoints: (① Taichong, ② Sanyinjiao, ③ Zusanli, ④ Xuehai, ⑤ Quchi, ⑥ Fengchi, ⑦ Dazhui, ⑧ Feishu, ⑨ Ganshu) a total of 9 acupoints and 17 injection points.

[0155] Acupoint injection method: Use two 10mL disposable sterile syringes to draw 10mL of the mixture according to the dosage prepared in Formula B, for a total of 20mL. Change to a No. 5 injection needle and perform routine skin disinfection before injection. Inject 1.5mL at each of the four injection points (Taichong and Ganshu), and divide the mixture equally at the remaining injection points. After inserting the needle, perform lifting, thrusting, and rotating movements until a tingling, numb, and distending sensation is felt. Aspirate the syringe; if no blood return is observed, proceed with the injection. Disinfect the injection site after completion. Administer once daily for three consecutive days.

[0156] Doctor's instructions: During treatment, take only Banlangen granules, 2 sachets / time, 3 times a day for 5 consecutive days. Discontinue other medications for treating shingles. After completing the daily injections, take oral antiviral medication and neurotrophic drugs for 5 days, and apply acyclovir cream topically. Follow up if any discomfort occurs.

[0157] A follow-up phone call was made more than 10 days later, and the patient reported no discomfort.

[0158] Clinical Treatment Case (VI)

[0159] Patient: Zhao, female, 54 years old. Address: Chaoyang Xincheng Community. Date: 2017.

[0160] Chief complaint: Pain in the buttocks for 5 days, accompanied by pain in the genital area and inner thigh for 3 days. The pain is like needle pricks, with a burning sensation, and is intermittent. The pain worsens at night, limiting movement and walking. The patient is afraid to touch the painful area. Two days later, erythema, rash and blisters appeared.

[0161] Physical examination: Patchy erythema, papules, papulovesicles, and clustered vesicles were visible on the patient's right buttock and inner thigh, with significant tenderness upon touch. Clustered papulovesicles were also visible on the perineum and labia majora.

[0162] Past medical history: lumbar spine disease, no history of drug allergies.

[0163] Diagnosis: Herpes zoster.

[0164] Treatment procedure: Acupuncture points were selected at L3-L5 and S1-S3 of the sacrum. Patients were placed in a supine or supine position. The injection sites were first marked (① Taichong, ② Sanyinjiao, ③ Zusanli, ④ Xuehai, ⑤ Quchi, ⑥ Fengchi, ⑦ Dazhui, ⑧ Feishu, ⑨ Ganshu). A total of 9 acupuncture points and 17 injection points were used.

[0165] Nerve root block injection method: Select L3-L5 and S1-S3 on the affected side. To ensure accurate injection, elevate the lumbar region and abdomen. Draw a vertical line along the midline of the vertebral bodies at L3-L5 and S1-S3 on the affected side. Draw another vertical line 1.5 cm lateral to the midline. Draw a horizontal line between the two vertebral bodies, intersecting the lateral lines to form a cross. Use two 10mL disposable sterile syringes, each drawing 10mL of the mixture for later use, for a total of 20mL. Change to a No. 5 injection needle and shake the mixture well before injection. After routine disinfection of the injection site, insert the needle at the intersection of the cross lines at a 90° angle to the skin, about 1-1.5 cm deep, then continue at an angle 5°-15° upwards and inwards towards the spine. During injection, if the patient experiences a tingling, numb, or distending sensation, aspirate the syringe. If no blood return is observed, slowly inject 3.3mL of the mixture. During the injection, aspirate the syringe multiple times to prevent the medication from entering the blood vessels. Insert the needle perpendicularly into the S1-S3 sacral foramen. When you feel a hollow sensation, it indicates that the needle has entered the sacral foramen. Withdraw the needle slightly, aspirate the syringe to ensure no blood flow, and slowly inject 3.3 mL of the mixture. During the injection, aspirate the syringe multiple times to prevent the medication from entering a blood vessel. (10 mL is injected into the three sacral foramen sites.) After the nerve root block injection is completed, routinely disinfect the lumbar and sacral injection sites and cover and secure them with sterile gauze. Administer once daily for three consecutive days.

[0166] Acupoint injection method: Use two 10mL disposable sterile syringes to draw 10mL of the mixture according to the dosage prepared in Formula B, for a total of 20mL. Change to a No. 5 needle and perform routine skin disinfection before injection. Inject 1.5mL at each of the four injection points (Taichong and Ganshu), and divide the mixture equally at the remaining injection points. After inserting the needle, perform lifting, thrusting, and rotating movements until a tingling, numb, and distending sensation is felt. Aspirate the syringe; if no blood return is observed, proceed with the injection. Disinfect the injection site after completion. Administer once daily for three consecutive days.

[0167] Doctor's instructions: During treatment, take only Banlangen granules, 2 sachets / time, 3 times a day for 5 consecutive days. Discontinue other medications for treating shingles. After completing the daily injections, take oral antiviral medication and neurotrophic drugs for 5 days, and apply acyclovir cream topically. Follow up if any discomfort occurs.

[0168] A follow-up phone call was made more than 10 days later, and the patient reported no discomfort.

[0169] Clinical Treatment Case (VII)

[0170] Patient: Zhao, female, 55 years old. Address: Olympic Garden. Date: 2012.

[0171] Chief complaint: Pain in the right buttock for 4 days, accompanied by pain in the outer thigh and calf for 3 days. The pain is described as a needle-like or electric shock-like sensation with a burning sensation. The pain is intermittent and worsens at night, limiting mobility and walking. The patient is afraid to touch the painful area. Two days later, erythema, rash, and blisters appeared.

[0172] Physical examination: Patchy erythema, papules, papulovesicles, and clustered vesicles were visible on the patient's right buttock, lateral thigh, and calf, with significant tenderness upon touch. Clustered papulovesicles were also visible.

[0173] Past medical history: lumbar spine disease, no history of drug allergies.

[0174] Diagnosis: Herpes zoster.

[0175] Treatment procedure: Acupuncture points were selected at L3-L5 and S1-S3 of the sacrum. Patients were placed in a supine or supine position. The injection sites were first marked (① Taichong, ② Sanyinjiao, ③ Zusanli, ④ Xuehai, ⑤ Quchi, ⑥ Fengchi, ⑦ Dazhui, ⑧ Feishu, ⑨ Ganshu). A total of 9 acupuncture points and 17 injection points were used.

[0176] Nerve root block injection method: Select L3-L5 and S1-S3 on the affected side. To ensure accurate injection, elevate the lumbar region and abdomen. Draw a vertical line along the midline of the vertebral bodies at L3-L5 and S1-S3 on the affected side. Draw another vertical line 1.5 cm lateral to the midline. Draw a horizontal line between the two vertebral bodies, intersecting the lateral lines to form a cross. Use two 10mL disposable sterile syringes, each drawing 10mL of the mixture for later use, for a total of 20mL. Change to a No. 5 injection needle and shake the mixture well before injection. After routine disinfection of the injection site, insert the needle at the intersection of the cross lines at a 90° angle to the skin, about 1-1.5 cm deep, then continue at an angle 5°-15° upwards and inwards towards the spine. During injection, if the patient experiences a tingling, numb, or distending sensation, aspirate the syringe. If no blood return is observed, slowly inject 3.3mL of the mixture. During the injection, aspirate the syringe multiple times to prevent the medication from entering the blood vessels. Insert the needle perpendicularly into the S1-S3 sacral foramen. When you feel a hollow sensation, it indicates that the needle has entered the sacral foramen. Withdraw the needle slightly, aspirate the syringe to ensure no blood flow, and slowly inject 3.3 mL of the mixture. During the injection, aspirate the syringe multiple times to prevent the medication from entering a blood vessel. (10 mL is injected into the three sacral foramen sites.) After the nerve root block injection is completed, routinely disinfect the lumbar and sacral injection sites and cover and secure them with sterile gauze. Administer once daily for three consecutive days.

[0177] Acupoint injection method: Use two 10mL disposable sterile syringes to draw 10mL of the mixture according to the dosage prepared in Formula B (total 20mL). Change to a No. 5 injection needle and perform routine skin disinfection before injection. Inject 1.5mL at each of the four injection points (Taichong and Ganshu), and divide the mixture equally at the remaining injection points. After inserting the needle, perform lifting, thrusting, and rotating movements until a tingling, numb, and distending sensation is felt. Aspirate the syringe; if no blood return is observed, proceed with the injection. Disinfect the injection site after completion. Administer once daily for three consecutive days.

[0178] Doctor's instructions: During treatment, take only Banlangen granules, 2 sachets / time, 3 times a day for 5 consecutive days. Discontinue other medications for treating shingles. After completing the daily injections, take oral antiviral medication and neurotrophic drugs for 5 days, and apply acyclovir cream topically. Follow up if any discomfort occurs.

[0179] A follow-up phone call was made more than 10 days later, and the patient reported no discomfort.

[0180] Finally, it should be noted that the above description is merely a preferred embodiment of the present invention and is not intended to limit the scope of protection of the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A compound pharmaceutical composition for treating herpes zoster, characterized in that, The drug compound composition is a combination of Formula A and Formula B; Based on a 20 mL mixture / cubic meter: Formula A is composed of the following parts by weight of raw materials: Lidocaine hydrochloride injection 5mL, vitamin B12 injection 3mL, vitamin B1 injection 2mL, ribavirin injection 4mL, prednisolone acetate injection 2mL and water for injection 4mL. Formula B is composed of the following parts by weight of raw materials: Lidocaine hydrochloride injection 2mL, vitamin B12 injection 3mL, vitamin B1 injection 2mL, ribavirin injection 4mL, dexamethasone injection 2mL, and water for injection 7mL.

2. A compound pharmaceutical preparation for treating herpes zoster, characterized in that, The formulation comprises the pharmaceutical combination composition for treating herpes zoster as described in claim 1.

3. A method for preparing a compound pharmaceutical preparation for treating herpes zoster as described in claim 2, characterized in that, Includes the following steps: S1. Select the raw materials in Formula A according to the corresponding mass fractions: lidocaine hydrochloride injection, vitamin B12 injection, vitamin B1 injection, ribavirin injection, prednisolone acetate injection and water for injection. Mix them well and divide them into two equal portions of 10 mL each for later use, for a total of 20 mL. This completes the preparation. S2. Select the raw materials in formula B according to the corresponding mass proportions: lidocaine hydrochloride injection, vitamin B12 injection, vitamin B1 injection, ribavirin injection, dexamethasone injection and water for injection. Mix them well and divide them into two equal portions of 10 mL each for later use, for a total of 20 mL, to complete the preparation.

4. The method for preparing a compound pharmaceutical preparation for treating herpes zoster according to claim 3, characterized in that, The compound drug preparation is for internal use.

5. A method of using a compound pharmaceutical preparation for treating herpes zoster as described in claim 3, characterized in that, The compound drug preparation is administered via injection into the nerve root site on the affected side and acupoints on the body.

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