An acupoint distance-based retreat closed-loop adjustment system based on photon neural coupling

Abstract

Embodiments of the present application provide a meridian point distance-based retreat closed-loop adjustment system based on photon neural coupling, comprising a processor assembly, a wearing assembly and six probe assemblies, six probe assemblies are arranged on the wearing assembly and form two three-probe groups; the probe assembly is used for outputting detection light to the corresponding tissue node, collecting optical response and outputting PBM light. It is related to the field of photoelectric detection and light biological regulation equipment. By arranging six probe assemblies on the wearing assembly and forming two three-probe groups, the three probe assemblies in each three-probe group can correspond to different tissue nodes respectively, which facilitates the grouped detection of the tissue nodes on both sides of the neck. The common mode change in the response of the target tissue node is removed by using the witness response, which can reduce the influence of user action, overall cycle change and external environment change on the detection result, and improve the recognition of the target tissue node response.

Description

Technical Field

[0001] This invention relates to the field of photoelectric detection and photobiological regulation equipment, specifically to a closed-loop regulation system for acupoint fixed-distance withdrawal based on photonic neural coupling. Background Technology

[0002] Photobiological modulation is a technique that uses light of a specific wavelength to irradiate target tissue in order to regulate the local physiological state of the tissue. Existing photobiological modulation devices typically output modulating light to the target area according to pre-set light intensity, output duration, and working cycle. Some devices also use optical probes to collect changes in tissue blood oxygenation to determine the tissue response before and after light irradiation.

[0003] However, the optical signals of neck tissue are easily affected by wearing position, probe fit, local contact pressure, user movements, and changes in overall circulation. When using a single probe for detection, the acquired results simultaneously include the local response of the target tissue node and common-mode variations caused by multiple interference factors, making it difficult to accurately distinguish the true response of the target tissue node. Even when using multiple probes to acquire data simultaneously, signal differences can easily arise between the probes due to variations in contact state and spatial position, affecting the comparison results between different tissue nodes.

[0004] Furthermore, existing equipment typically separates the detection process from the photobiological regulation process. The photobiological regulation parameters are mainly determined based on preset programs, making it difficult to select working nodes and adjust output parameters according to the oxygenation and oxygen utilization status of different tissue nodes. After completing one light output, if the tissue node response is not re-acquired, it is also difficult to determine in a timely manner whether the current light output has achieved the expected regulation effect, which can easily lead to a mismatch between output parameters and the actual tissue response.

[0005] Current equipment processing of optical response often focuses on single peak values, amplitude variations, or differences between adjacent time points. It is difficult to unify response settling speed, peak intensity, recovery process, fluctuation complexity, and periodic phase changes into a quantifiable result that can be continuously compared. When the original signal dimensions and fluctuation ranges corresponding to different users, different acupoints, or different PBM optical output parameters are different, directly adjusting the output parameters based on single characteristics can easily allow random fluctuations to affect the operating node and parameter selection.

[0006] Furthermore, judging whether peripheral acupoint muscle oxygenation timing and central cerebral blood oxygenation timing are coupled solely based on their correlation is insufficient to distinguish between common cyclical changes, reversed time sequences, and spurious couplings that do not conform to physiological response delays. Without cascading determination of the information flow direction from the periphery to the central nervous system and the central response delay, invalid photon output parameters may still enter subsequent closed-loop regulation.

[0007] Therefore, it is necessary to provide a closed-loop adjustment system for acupoint fixed-distance withdrawal based on photonic neural coupling to reduce the impact of common-mode changes on tissue node response identification, and to perform closed-loop adjustment of PBM light output according to tissue oxygenation response and oxygen utilization response. Summary of the Invention

[0008] According to embodiments of the present invention, a closed-loop regulation system for acupoint fixed-distance withdrawal based on photonic neural coupling is provided. This system is used to solve the technical problems existing in the background art described above.

[0009] In a first aspect of the present invention, a closed-loop regulation system for acupoint fixed-distance withdrawal based on photonic neural coupling is provided.

[0010] The acupoint fixed-distance withdrawal closed-loop adjustment system based on photonic neural coupling includes a processor component, a wearable component, and six probe components. The six probe components are mounted on the wearable component and form two three-probe groups. The probe assembly is used to output detection light to the corresponding tissue node, acquire optical response, and output PBM light; the processor assembly controls the three probe assemblies in the same three-probe group to output test light pulses to the corresponding tissue node in sequence, and when one of the probe assemblies outputs a test light pulse, the other two probe assemblies synchronously acquire witness response, remove common mode variation in the target tissue node response based on the witness response, obtain tissue oxygenation response and oxygen utilization response of each tissue node, and control the corresponding probe assembly to output PBM light based on the tissue oxygenation response and oxygen utilization response, and reacquire tissue node response after output.

[0011] Preferably, the processor component obtains the relative level of each tissue node, the gradient between nodes, the fluctuation coherence, and the propagation delay based on the optical responses acquired by the two three-probe groups.

[0012] Preferably, the probe assembly outputs PBM light according to preset PBM light output parameters, including light output power, single output dose, and continuous working time. The processor assembly adjusts the PBM light output parameters according to the response changes of the corresponding tissue node.

[0013] Preferably, the processor component obtains the oxygen transport response and oxygen utilization response of the corresponding tissue node based on the relative changes of oxyhemoglobin, deoxyhemoglobin, and oxidized cytochrome c oxidase.

[0014] Preferably, the two three-probe groups correspond to the target tissue areas on both sides of the back of the neck, and the processor component determines the current working node based on node-specific response, relaxation characteristics and safety margin, and controls the probe component corresponding to the current working node to output PBM light.

[0015] Preferably, the processor component compares the node-specific response and relaxation characteristics before and after PBM light output; when the node-specific response per unit energy remains stable and no temperature anomaly, overshoot, or reverse response occurs, the subsequent PBM light output parameters are maintained or adjusted; when marginal response decreases, relaxation time increases, contact changes occur, or temperature exceeds limits, the PBM light output is reduced or stopped.

[0016] Preferably, the processor component extracts the rising slope, peak amplitude, recovery half-life, fluctuating Shannon entropy, and peak-valley phase shift from the muscle oxygenation time sequence of fixed acupoints to form a five-dimensional feature matrix; outlier removal, normalization, and principal component analysis are performed on the five-dimensional feature matrix, and the matrix is ​​weighted and fused according to the variance contribution rate of each principal component to obtain the acupoint effect quantification index TEQI.

[0017] Preferably, the processor component performs time alignment between the peripheral acupoint muscle oxygenation time series and the synchronously obtained prefrontal cortex central cerebral blood oxygenation time series, performs Granger causality test and bidirectional transfer entropy calculation on the aligned time series, and obtains the central coupling quantification index JTEQI based on the difference between peripheral to central transfer entropy and central to peripheral transfer entropy and the central response delay.

[0018] Preferably, when the difference between the peripheral-to-central transfer entropy and the central-to-periphery transfer entropy is less than or equal to zero, or when the central response delay exceeds the allowable range of 6.76s±1.5s, the processor component marks the current PBM optical output parameters as invalid and selects the next set of PBM optical output parameters from the preset parameter set to perform re-output and retesting.

[0019] Preferably, the probe assembly employs at least three near-infrared detection wavelengths: At least one detection wavelength is located in the range of 750nm to 780nm; At least one detection wavelength is located in the range of 800nm ​​to 835nm; At least one detection wavelength is located in the range of 840 nm to 860 nm to obtain the relative changes of oxygenated hemoglobin, deoxygenated hemoglobin, and oxidized cytochrome c oxidase.

[0020] Preferably, the two three-probe groups can work sequentially, synchronously, or alternately. The processor component saves the contact state and optical baseline of the two three-probe groups respectively, and controls the PBM light output parameters of each probe component in the two three-probe groups respectively.

[0021] Preferably, it also includes a monitoring component corresponding to the six probe components. The probe components are movable relative to the wearable component. The monitoring component is disposed on the outside of the corresponding probe component and is movable relative to the probe component during the process of the probe component being in contact with the skin to generate a corresponding contact signal.

[0022] Preferably, the processor component is connected to both the probe component and the monitoring component; after all three monitoring components corresponding to the same three-probe group generate stable contact signals, the processor component records the contact positions of the three probe components and controls the three probe components to retract the same predetermined distance along their respective contact directions; when the contact signal of any monitoring component is released, the light output of the corresponding three-probe group is stopped.

[0023] One or more technical solutions provided in this application have at least the following technical effects or advantages: The present invention provides a closed-loop adjustment system for acupoint fixed-distance withdrawal based on photonic nerve coupling. By setting six probe components on the wearable component and forming two three-probe groups, the three probe components in each three-probe group can correspond to different tissue nodes, which facilitates the group detection of tissue nodes on both sides of the neck.

[0024] The three probe components in the same three-probe group sequentially output test light pulses. While one probe component outputs a test light pulse, the witness response is simultaneously acquired by the other two probe components. By utilizing the witness response to remove common-mode variations in the target tissue node response, the impact of user actions, overall cyclical changes, and external environmental changes on the detection results can be reduced, thereby improving the identification accuracy of the target tissue node response.

[0025] By integrating the five-dimensional acupoint muscle oxygenation time-series characteristics into TEQI through principal component analysis and variance contribution rate weighting, it is possible to characterize the acupoint response intensity, establishment speed, recovery efficiency and fluctuation state simultaneously while eliminating dimensional differences, providing a unified peripheral response comparison scale for different PBM light output parameters.

[0026] By using the Granger causality test, the cascaded determination of the bidirectional transfer entropy difference and the central response delay, results that do not conform to the peripheral driving relationship or whose response delay deviates from the allowable range can be excluded. Invalid results do not enter the parameter maintenance condition and trigger the trial and retest of the next set of PBM optical output parameters, thereby reducing the impact of spurious coupling on closed-loop regulation.

[0027] It should be understood that the description in the Summary of the Invention is not intended to limit the key or essential features of the embodiments of the present invention, nor is it intended to restrict the scope of the invention. Other features of the invention will become readily apparent from the following description. Attached Figure Description

[0028] The above and other features, advantages, and aspects of the various embodiments of the present invention will become more apparent from the accompanying drawings and the following detailed description. In the drawings, the same or similar reference numerals denote the same or similar elements, wherein: Figure 1 A schematic diagram of the processor component processing flow of the acupoint fixed-distance withdrawal closed-loop adjustment system based on photonic neural coupling according to an embodiment of the present invention is shown. Figure 2 A schematic diagram of the three-dimensional connection structure of a closed-loop adjustment system for acupoint fixed-distance withdrawal based on photonic neural coupling according to an embodiment of the present invention is shown. Figure 3 An exploded structural schematic diagram of an acupoint fixed-distance withdrawal closed-loop regulation system based on photonic neural coupling according to an embodiment of the present invention is shown. Figure 4 A schematic diagram of the connection structure of the mounting housing, drive component, monitoring assembly and main adjustment unit according to an embodiment of the present invention is shown. Figure 5 A schematic diagram of the connection structure between the wearable component and the probe adjustment structure according to an embodiment of the present invention is shown; Figure 6 A cross-sectional view of the connection structure of the main adjustment unit, sub-adjustment units, drive components, and mounting housing according to an embodiment of the present invention is shown. Figure 7 An exploded structural schematic diagram of the mounting housing, main adjustment unit, drive component, and monitoring assembly according to an embodiment of the present invention is shown; Figure 8 A cross-sectional view of the connection structure between the main adjustment unit and the sub-adjustment units according to an embodiment of the present invention is shown; Figure 9 A cross-sectional structural schematic diagram of the main adjustment section according to an embodiment of the present invention is shown; Figure 10 A cross-sectional view of the connection structure of the driving component, probe assembly, and monitoring component according to an embodiment of the present invention is shown. Figure 11 A schematic diagram of the connection structure of the three drive components, three monitoring components and air pump in the same three-probe group according to an embodiment of the present invention is shown.

[0029] The attached figures are labeled as follows: 1-Processor assembly; 11-Processing unit; 12-Wire; 13-Receiver; 2-Wearable assembly; 21-Elastic element; 22-Contact end; 23-Anti-slip pad; 3-Main adjustment unit; 31-First sphere; 32-First spherical seat; 321-Through hole; 33-First arc-shaped shell; 331-Opening; 34-Second arc-shaped shell; 35-Handle; 36-Knob; 37-Rod; 38-First screw; 39-Bracket; 310-Moving plate; 311-Extension rod; 3111 - Guide groove; 4- Adjustment section; 41- Micro motor; 42- Second screw; 43- Block; 44- Limiting rod; 45- Slide groove; 5- Drive component; 51- Second spherical seat; 52- Electromagnet; 53- Second sphere; 54- Branch pipe; 55- Piston rod; 56- Adjusting valve; 57- Main pipe; 58- Air chamber; 59- Air pump; 6- Probe assembly; 7- Monitoring assembly; 71- Cylinder; 711- Rubber ring; 72- Annular back plate; 73- Contact switch; 8- Mounting housing. Detailed Implementation

[0030] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. Other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are all within the scope of protection of the present invention.

[0031] In addition, the term "and / or" in this article is used to describe the relationship between related objects; "connection" includes direct connection and indirect connection formed through intermediate structure; "fitting reference position" refers to the position of the piston rod 55 when the probe assembly 6 and the skin reach the specified fit state; "retraction distance" refers to the distance that the piston rod 55 moves away from the corresponding fitting reference position away from the skin.

[0032] In this embodiment, when the system is worn around the user's neck, the side closer to the neck skin is defined as the inner side, and the side away from the neck skin is defined as the outer side. The direction in which the probe assembly 6 approaches or moves away from the neck skin is defined as the axis of the corresponding probe assembly 6. The three probe assemblies 6 on each mounting shell 8 constitute a three-probe group, and the two mounting shells 8 each form a three-probe group that can operate independently.

[0033] like Figures 1 to 11As shown, this embodiment provides a closed-loop adjustment system for acupoint positioning and withdrawal based on photonic neural coupling. The system includes a processor assembly 1, a wearable assembly 2, two main adjustment units 3, two sub-adjustment units 4, six drive components 5, six probe assemblies 6, six monitoring components 7, and two mounting housings 8. Each mounting housing 8 corresponds to one main adjustment unit 3 and one sub-adjustment unit 4, and carries three drive components 5, three probe assemblies 6, and three monitoring components 7. A total of six probe assemblies 6 are mounted on the two mounting housings 8.

[0034] In this embodiment, the processing unit 11 divides the monitoring and closed-loop adjustment process within the probe assembly 6 into an optical acquisition module, a status confirmation module, a three-probe rotation detection module, a witness differential module, a pulse relaxation identification module, and a PBM closed-loop adjustment module, following the processing sequence of data acquisition, status confirmation, node probing, differential correction, relaxation identification, and PBM closed-loop adjustment. Each module is implemented through the program logic in the processing unit 11, with the detection results, status flags, or characteristic parameters of the previous module serving as the input or start-up conditions for the next module.

[0035] The optical acquisition module is used to obtain the optical response of each tissue node. Specifically, each probe assembly 6 is internally equipped with a measurement light emission section, a photodetector section, and a PBM light output section. The measurement light emission section is used to emit red or near-infrared light of at least one detection wavelength into the neck tissue. The photodetector section is used to receive the light signals scattered and absorbed by the skin and internal tissues and convert them into electrical signals. The PBM light output section is used to output photobiologically modulated light to the target location according to the pulse parameters given by the processing unit 11.

[0036] The measurement light emission section and the photoelectric detection section are preferably arranged coaxially or nearly coaxially. The PBM light output section can share the same light output window as the measurement light emission section, or they can have independent light output windows. Light-blocking structures are set between each optical path to reduce crosstalk between the measurement light, PBM light, and internal direct light. The black field reference light path and temperature detection structure are both integrated inside the probe assembly 6 and are used together with the optical acquisition results for quality judgment.

[0037] The probe assembly 6 can also internally incorporate a light-blocking structure, a temperature detection structure, a light intensity reference structure, and a black field reference optical path. The light-blocking structure reduces internal direct light crosstalk, the black field reference optical path obtains the baseline for dark current, ambient light leakage, and crosstalk between adjacent probes when both the measurement light and PBM light are turned off, and the temperature detection structure detects the temperature of the probe and the skin-contact area. Using the working optical path, reference optical path, and temperature status together for quality assessment reduces the impact of ambient light, temperature drift, and treatment light crosstalk on the test results.

[0038] The probe assembly 6 preferably employs three or more near-infrared detection wavelengths, which may include wavelengths around 760nm, 830nm, and 850nm. Other discrete detection wavelengths can be added based on spectral separation accuracy. Detection results around 760nm and 850nm are primarily used to distinguish the relative changes of oxyhemoglobin and deoxyhemoglobin, while detection results around 830nm are used to improve the sensitivity to relative changes of oxidized cytochrome c oxidase. The processing unit 11 calculates the change in optical density based on the change in received light intensity relative to the reference light intensity at different detection wavelengths, and combines this with a pre-calibrated differential path factor or empirical conversion coefficient to obtain the relative changes of oxyhemoglobin, deoxyhemoglobin, and oxidized cytochrome c oxidase. This allows for continuous acquisition of oxygenation and oxygen utilization changes at the same tissue node without altering the probe's mechanical position, providing a unified measurement basis for subsequent PBM parameter adjustments. These relative changes are only used for closed-loop device adjustment and are not directly used as disease diagnosis results.

[0039] In one embodiment: the probe assembly 6 employs at least three near-infrared detection wavelengths: At least one detection wavelength is located in the range of 750nm to 780nm; At least one detection wavelength is located in the range of 800nm ​​to 835nm; At least one detection wavelength is located in the range of 840nm to 860nm, thereby enabling the acquisition of relative changes in oxyhemoglobin, deoxyhemoglobin, and oxidized cytochrome c oxidase.

[0040] The status confirmation module is used to determine whether the current mechanical and optical statuses meet the requirements for detection or PBM output. The processing unit 11 divides a detection and adjustment process into mechanical status confirmation, black field acquisition, baseline measurement, three-probe rotation trial, pulse relaxation measurement, node response identification, PBM pulse output, and post-output retest. Only when all three contact switches 73 in the same group are stably triggered, the three second balls 53 are locked, the positions of the three piston rods 55 are stable, the pressure of the main pipe 57 is within the allowable range, the micro motor 41 is stopped, and the air pump 59 is in a stopped or stable state, will the processing unit 11 allow the corresponding three-probe group to enter the detection or PBM output state.

[0041] The processing unit 11 also checks the black field signal, detection light intensity, detector saturation state, and temperature state of the probe assembly 6. If any mechanical or optical state fails to meet the requirements, the data for the corresponding time period will not be included in the three-probe differential calculation. By setting the detectable mechanical state as a prerequisite for optical operation, it is possible to avoid signals generated when the probe is moving, has a localized loose connection, or is under unstable pressure being mistaken for tissue responses.

[0042] The three-probe rotation detection module is used to ensure that the three probe components 6 in the same group act as excitation probes in turn, while the other two probe components 6 act as witness probes for synchronous acquisition. The three probe components 6 in each three-probe group correspond to three tissue nodes set at intervals. In the first round, the first probe component 6 outputs a low-energy test light pulse to the corresponding node, while the other two probe components 6 act as witness probes for synchronous acquisition. In the second round, the second probe component 6 outputs a test light pulse, while the first and third probe components 6 act as witness probes. In the third round, the third probe component 6 outputs a test light pulse, while the other two probe components 6 act as witness probes.

[0043] The center lines connecting the three probe components 6 in the same group preferably form an equilateral or isosceles triangle, and the center distance between adjacent probe components 6 is preferably 8mm to 25mm. After each probe component 6 is attached to the skin, the angle between the normal of its light-emitting surface and the normal of the skin at the corresponding attachment position is preferably no greater than 15°. The above geometric relationship not only gives the three tissue nodes a spatially distinguishable position, but also enables the two witness probes to collect common-mode changes near the excitation nodes, thus providing a geometric basis for subsequent spatial difference analysis.

[0044] Each round of testing sequentially includes pre-test blackout, baseline acquisition, test pulse, relaxation window acquisition, and post-test blackout. Pre-test blackout is used to correct for dark current and ambient light leakage before testing; baseline acquisition obtains the optical reference for the corresponding node before testing; relaxation window acquisition obtains the tissue response after the test pulse ends; and post-test blackout is used to determine whether temperature drift, ambient light changes, or crosstalk between adjacent probes occurred during this round. This timing sequence ensures that the test response and testing reference are obtained under the same mechanical contact state, thereby improving comparability between different rounds.

[0045] When the i-th probe assembly 6 is used as the excitation probe and the j-th probe assembly 6 is used as the detection probe, the processing unit 11 records the response obtained by the j-th probe assembly 6 as R. ij After three rounds of testing, a 3x3 node response matrix is ​​formed. This matrix corresponds to the probe assembly 6 that outputs the test light pulse and the probe assembly 6 that receives the test response. The diagonal terms of the matrix include the excitation node's own response, systematic changes, and probe coupling changes, while the off-diagonal terms include remote synchronization changes, common-mode changes caused by respiration and heartbeat, and coupling changes of the witness probe itself.

[0046] The witness differential module is used to construct a common-mode component based on the two witness probes and remove the common-mode component and shallow coupling component from the response of the excitation probe. The processing unit 11 performs quality weighting on the witness signal based on the contact state of the two witness probes, the pressure of the main pipe 57, the positional stability of the piston rod 55, the black field signal, and the detection light intensity. When both witness probes are stably attached and their changing trends are consistent, a common-mode component is constructed based on both probes, and the common-mode component and shallow coupling component are removed from the diagonal response of the excitation probe to obtain the node-specific response. This allows the spatial difference relationship between the three probes in the same group to weaken the combined effects of changes in respiration, heartbeat, body movement, and overall perfusion, improving the identification of the target node response.

[0047] If the difference between the two witness probes exceeds the allowable range, or if either contact switch 73 is detrimentalized or continues to jitter, the processing unit 11 marks the current data as indicating unstable adhesion and re-executes mechanical condition verification and optical quality checks, instead of directly interpreting the difference as a tissue response. This processing reduces spurious responses from position drift, changes in contact pressure, or ambient light leakage from entering the node response matrix.

[0048] The pulse relaxation identification module extracts tissue response features from the relaxation curve after the trial light pulse ends. After the trial light pulse ends, the PBM light output section remains off, while the light emission measurement section continues to operate within a specified relaxation window. The processing unit 11 extracts the response peak, initial slope, specified proportional decay time, time required to recover to the baseline tolerance range, curve integral area, overshoot or reverse response, and the temporal relationship between the relative change in oxidized cytochrome c oxidase and the relative change in hemoglobin from the relaxation curve. Compared to simply comparing two static values ​​before and after the trial, these relaxation features can reflect the speed of tissue response establishment, duration, and recovery process.

[0049] Processing unit 11 divides the three-probe detection results into a topology response layer, an oxygen transport and utilization response layer, and a PBM execution layer. The topology response layer is used to obtain the relative level of the three nodes, the gradient between nodes, the wave coherence, and the propagation delay; the oxygen transport and utilization response layer is used to obtain the changes in hemoglobin, the changes in oxidized cytochrome c oxidase, and the relaxation characteristics after the probe light pulse; the PBM execution layer selects the working node and adjusts the PBM light pulse parameters based on the node-specific response, relaxation characteristics, and safety margin.

[0050] In one embodiment of acupoint effect quantification, the processing unit 11 establishes the acupoint effect quantification index (TEQI) after completing witness differential analysis and pulse relaxation identification. Fixed acupoints may include at least one of Fengchi (GB20), Fengfu (GV16), and Sanyinjiao (SP6), wherein the muscle oxygenation timing corresponding to Fengchi and Fengfu can be obtained by the neck probe assembly 6; when the muscle oxygenation timing of Sanyinjiao needs to be introduced, the processing unit 11 receives external near-infrared detection data using the same sampling clock or carrying a unified timestamp through the receiving unit 13. Thus, neck tissue node data and cross-site acupoint data can both enter the subsequent feature extraction process according to the same data structure.

[0051] Processing unit 11 converts the original detected light intensity into a time series of relative concentrations of oxyhemoglobin and deoxyhemoglobin according to the modified Beer-Lambert law, and performs bandpass filtering of 0.01Hz to 0.5Hz on the time series used for TEQI calculation. Subsequently, a sliding window variance threshold is used to identify motion artifacts, eliminating windows exceeding the threshold or setting invalid markers for the corresponding windows, and baseline correction is performed using the average value of the aforementioned trial light pulse output for the first 30 seconds as the baseline. This preprocessing ensures that each acupoint time series has the same sampling starting point and baseline definition.

[0052] Processing unit 11 extracts five-dimensional features from the preprocessed oxygenated hemoglobin time series. The rising slope is the maximum positive slope obtained by linear least-squares fitting within the interval from baseline to response peak; the peak amplitude is the difference between the response peak and the baseline mean; the recovery half-life is the time it takes for the response peak to fall back to 50% of its peak amplitude; the fluctuation Shannon entropy is the information entropy corresponding to the probability distribution of oxygenated hemoglobin values ​​within the sliding window; and the peak-valley phase shift is the time shift of the response peak and valley relative to the peak and valley positions of the reference period. These features characterize the response setup speed, maximum response intensity, recovery efficiency, fluctuation complexity, and rhythm shift, respectively.

[0053] Processing unit 11 performs outlier removal (three standard deviations) on the five-dimensional feature data and normalizes each feature to the 0-1 interval. Then, it performs principal component analysis on the normalized feature matrix, retaining principal components whose cumulative variance contribution rate reaches a preset threshold. The variance contribution rate of each principal component is used as the corresponding weight for weighted summation, and the weighted result is linearly mapped to the 0-100 interval to obtain the TEQI. Compared to manually pre-specifying fixed weights for the five features, determining weights using the variance contribution rate of the current sample set can reduce the impact of collinear features repeatedly amplifying the same response change.

[0054] In one implementation of central coupling quantization, the processing unit 11 receives the central cerebral blood oxygenation time series output from the prefrontal near-infrared detection channel via the receiving unit 13, and aligns it with the peripheral acupoint muscle oxygenation time series according to the sampling timestamp. Before alignment, time periods with unstable adhesion, abnormal black field, or unqualified optical quality are deleted. The retained time series are uniformly subjected to 0.01Hz to 0.1Hz bandpass filtering and baseline correction to obtain the peripheral time series P(t) and the central time series C(t). Unifying the frequency band and time reference can reduce the impact of sampling rate differences and high-frequency noise on the directionality calculation.

[0055] Processing unit 11 establishes a vector autoregressive model for P(t) and C(t), comparing the prediction error between a restricted model using only the historical term of C(t) and a complete model using the historical terms of both P(t) and C(t). The Granger causal significance score of the peripheral time series on the central time series is obtained using the F-statistic and significance probability. This score characterizes the degree to which the addition of peripheral historical information improves the predictive ability of the central time series, rather than directly using synchronization correlation as a directional result.

[0056] Processing unit 11 also calculates the transfer entropy TEP→C from the periphery to the center and the transfer entropy TEC→P from the center to the periphery, and calculates the directional coupling difference ΔTE=TEP→C-TEC→P. The transfer entropy calculation determines the directional information flow strength based on the reduction of the uncertainty of the future state of one time series to the historical state of another time series, and forms a complementary judgment with the Granger causality significance score to form a linear prediction relationship and a nonlinear information flow relationship.

[0057] Processing unit 11 obtains the central response delay τ based on the difference between the peak time of the peripheral response and the peak time of the central response, and uses 6.76s as the reference delay for the hemodynamic response function, with 6.76s ± 1.5s as the allowable interval. Processing unit 11 weights and merges the normalized Granger causality significance score, ΔTE, and the corresponding delay validity weights, and maps them to the 0-100 interval to obtain JTEQI; the closer τ is to the reference delay, the greater the delay validity weight; when τ exceeds the allowable interval, the delay validity marker is set to invalid.

[0058] In practical use, the processing unit 11 first compares the peripheral meridian response corresponding to the current parameters with TEQI, and then uses JTEQI to determine whether the peripheral response forms a central coupling that meets the requirements of direction and time delay. When ΔTE≤0 or τ exceeds the 6.76s±1.5s range, the processing unit 11 marks the current detection data and the current PBM light output parameters as invalid, and does not use the TEQI increase as the basis for maintaining parameters; then it turns off the PBM light output, waits for the peripheral and central timing to recover to the baseline tolerance range, and selects the next set of light output power, single output dose, pulse interval or continuous working time from the preset parameter set, and re-executes the fit confirmation, baseline acquisition, trial output and double exponential calculation.

[0059] When ΔTE is greater than zero, τ is within the allowable range, and no temperature anomalies, overshoot, reverse response, or contact changes occur, processing unit 11 records the current parameter as a valid candidate parameter and, based on the relative changes in TEQI and JTEQI, determines whether to maintain the current parameter or select an adjacent candidate parameter to continue testing. Parameter iteration is always limited by a preset safety range, maximum continuous working time, and maximum number of iterations; PBM light output is stopped when any of these limitations are met. The aforementioned dual exponents serve only as quantitative parameters and validity conditions in the closed-loop regulation of the equipment and are not directly used as disease diagnosis results.

[0060] The PBM closed-loop adjustment module is used to determine the working node and output parameters based on the node-specific response, relaxation characteristics, and safety margin. The processing unit 11 selects a node whose node-specific response direction matches the preset adjustment target, has good repeatability, and a large safety margin as the current working node, and controls the corresponding probe assembly 6 to output the first PBM pulse packet. After each PBM pulse packet, the PBM light output is turned off, and the bonding confirmation, black field acquisition, and relaxation measurement are re-executed. When the node-specific response per unit energy remains stable and no temperature anomalies, overshoot, or reverse response occur, subsequent pulse packets can be maintained or adjusted. When marginal response decreases, relaxation time prolongs, contact changes occur, or temperature exceeds limits, the output is reduced or stopped. This forms a closed loop of "detection—trial—identification—adjustment—retesting," avoiding the continuous use of a fixed dose when there is a lack of response data.

[0061] Two three-probe groups establish node response matrices and fit quality markers respectively, and can work sequentially, synchronously, or alternately. The processing unit 11 saves the fit reference position, retraction distance, contact state, and optical baseline of the two groups respectively, without requiring the left and right groups to have the same extension position or air pressure, thus adapting to the curvature difference on both sides of the posterior neck.

[0062] The mechanical structure of this system and its adjustment process are described in detail below with reference to the accompanying drawings.

[0063] The processor assembly 1 includes a processing unit 11, a wire 12, and a receiver 13. The processing unit 11 is connected to the receiver 13 via the wire 12. The receiver 13 is located on one of the contact ends 22 and serves as the signal and control interface for the wearable device. The receiver 13 is connected to a micro motor 41, an electromagnet 52, an air pump 59, a regulating valve 56, a contact switch 73, a probe assembly 6, and displacement and pressure sensors via wires inside the elastic element 21. This allows the detection, position, pressure, and contact signals from the two mounting housings 8 to be centrally transmitted to the processing unit 11, and the same processing unit 11 coordinates the mechanical actions and optical output.

[0064] The wearable component 2 includes an elastic element 21, two contact ends 22, and two anti-slip pads 23. The elastic element 21 has an overall "n"-shaped structure with an opening on one side. The two contact ends 22 are respectively connected to the two ends of the elastic element 21, and the anti-slip pads 23 are disposed on the side of the corresponding contact end 22 facing the neck. The elastic element 21 adopts an engineering plastic, metal elastic sheet, or a combination of both that can elastically open. After wearing, the elastic restoring force makes the two contact ends 22 abut against the sides of the neck. The anti-slip pads 23 are used to increase friction and distribute clamping force, thereby limiting the overall slippage of the wearable component 2 when the user slightly turns their head or swallows.

[0065] The elastic element 21 has an internal cavity, in which two mounting shells 8 are respectively embedded and located on the left and right sides of the back of the neck. One side of the mounting shell 8 with the second spherical seat 51 faces the neck, and the other side with the connecting block 43 faces outwards, allowing the three probe assemblies 6 to extend from the inside of the elastic element 21 into the skin. The cavity also serves to accommodate wires. The wires are flexible segments near the first sphere 31 and the second sphere 53 with pre-reserved bending allowance, thereby preventing the wires from being pulled or restricting the rotation of the spheres during adjustment.

[0066] The main adjustment unit 3 is used to adjust the overall orientation of the corresponding mounting shell 8 and the three probe assemblies 6 in the same group. It includes a first ball 31, a first spherical seat 32, a first arc-shaped shell 33, a second arc-shaped shell 34, a handle 35, a knob 36, a rod 37, a first screw 38, a bracket 39, a moving plate 310, and an extension rod 311. The bracket 39 is connected to the outside of the elastic member 21. The first spherical seat 32 and the first arc-shaped shell 33 are both fixedly connected to the bracket 39. The first ball 31 is rotatably disposed within the first spherical seat 32.

[0067] A through hole 321 is provided on the side of the first spherical seat 32 away from the mounting shell 8. An extension rod 311 is connected to the side of the first sphere 31 away from the mounting shell 8, and the extension rod 311 passes through the through hole 321. An opening 331 is provided in the middle of the first arc-shaped shell 33. The extension rod 311 also passes through the opening 331 and can swing within the angle range defined by the through hole 321 and the opening 331. The first spherical seat 32 is used to support the first sphere 31 and define the rotation center. The through hole 321 and the opening 331 together define the swing range of the extension rod 311, thereby preventing the mounting shell 8 from rotating to a direction beyond the required direction.

[0068] The first arc-shaped shell 33 is a fixed friction end, and the second arc-shaped shell 34 is disposed outside the extension rod 311 and serves as a movable clamping end. The outer arc surface of the second arc-shaped shell 34 can fit against the inner arc surface of the first arc-shaped shell 33, and the contact surfaces of the two are provided with a frosted layer or friction texture. The end of the extension rod 311 away from the mounting shell 8 is connected to a handle 35. A straight groove is provided inside the handle 35, and the rod body 37 is rotatably connected in the straight groove. One end of the rod body 37 is connected to a knob 36, and the other end is connected to a first screw 38.

[0069] The first screw 38 is threadedly connected to the movable plate 310. A guide groove 3111 is provided on the side of the extension rod 311. The movable plate 310 is slidably connected to the guide groove 3111 and connected to the inner side of the second arc-shaped shell 34. The guide groove 3111 restricts the movable plate 310 from rotating with the first screw 38, causing the movable plate 310 to move axially along the extension rod 311 and drive the second arc-shaped shell 34 to approach or move away from the first arc-shaped shell 33.

[0070] In actual use, the operator turns knob 36 to disengage the second arc-shaped shell 34 from the first arc-shaped shell 33, releasing the frictional locking force between them; then, by holding handle 35 and swinging extension rod 311, the first ball 31 rotates within the first spherical seat 32, adjusting the overall orientation of the mounting shell 8 and the three probe assemblies 6 in the same group. After reaching the target direction, knob 36 is turned in the opposite direction, causing the second arc-shaped shell 34 to press against the first arc-shaped shell 33. The two arc surfaces generate frictional holding force through the frosted contact surface, locking the current direction.

[0071] The entire group is oriented by the first sphere 31 and locked from the side away from the skin by two arc-shaped shells, allowing the operator to adjust the overall orientation of the three-probe group without touching the front end of the probe. The concentric or matching arc surfaces can form a relatively stable contact area at different angles, reducing edge contact and locking force fluctuations that are prone to occur when using planar clamping parts.

[0072] Both the first sphere 31 and the extension rod 311 have interconnected cavities inside, through which wires can pass to connect the micro motor 41 and the internal components of the mounting housing 8. By making the wiring path close to the rotation center of the first sphere 31, the bending and displacement of the wires when the first sphere 31 is adjusted can be reduced, thus improving the reliability of the internal wiring.

[0073] The first sphere 31 is connected to the mounting shell 8 via a sub-adjustment section 4. The sub-adjustment section 4 includes a micro motor 41, a second screw 42, a block 43, a limiting rod 44, and a sliding groove 45. The micro motor 41 is disposed inside the first sphere 31, and its output end is connected to the second screw 42; the block 43 is threadedly connected to the second screw 42, and one side of the block 43 is connected to the mounting shell 8; the limiting rod 44 is connected to the block 43 and slidably connected to the sliding groove 45 opened along the axial direction of the second screw 42.

[0074] When the micro motor 41 drives the second screw 42 to rotate, the limiting rod 44 and the sliding groove 45 restrict the block 43 from rotating with the second screw 42, causing the block 43 to drive the mounting shell 8 to approach or move away from the neck along the axial direction of the second screw 42. The adjustment section 4 is used to feed the three probe assemblies 6 of the same group into the effective stroke range of the drive component 5. After the distance coarse adjustment is completed, the micro motor 41 stops. This structure separates the overall distance coarse adjustment from the subsequent single probe contact stroke, which can reduce the use of pneumatic stroke to compensate for large wearing gaps and reserve working stroke for synchronous retraction.

[0075] Each mounting housing 8 has three second spherical seats 51 connected to the side facing the neck. The three second spherical seats 51 and the block 43 are located on opposite sides of the mounting housing 8. The drive component 5 includes a second spherical seat 51, an electromagnet 52, a second sphere 53, a branch pipe 54, a piston rod 55, a regulating valve 56, a main pipe 57, an air chamber 58, and an air pump 59. The second sphere 53 is rotatably mounted inside the second spherical seat 51, and the electromagnet 52 is located inside the second spherical seat 51. The second sphere 53 is made of a material that can be attracted by the electromagnet 52 or has a magnetic layer.

[0076] When the electromagnet 52 is not energized, the second sphere 53 can rotate relative to the second spherical seat 51, allowing the corresponding probe assembly 6 to adapt to the normal direction of the local neck surface. When the electromagnet 52 is energized, it attracts the second sphere 53, increasing the contact pressure and friction between the second sphere 53 and the second spherical seat 51, thereby limiting the continued rotation of the second sphere 53. Thus, the three probe assemblies 6 in the same group can each form different tilt angles, avoiding the rigid parallel arrangement that would cause some probes to be pressed tightly while others are loosely connected.

[0077] The second sphere 53 has an internal air chamber 58. The piston rod 55 is slidably connected to the inner wall of the air chamber 58. The end of the piston rod 55 away from the air chamber 58 is connected to the probe assembly 6. When the piston rod 55 extends or retracts, it drives the probe assembly 6 to approach or move away from the skin along the axis of the second sphere 53 after it is locked, so that the distance switching does not change the already determined probe direction.

[0078] The air chamber 58 is connected to branch pipes 54, each branch pipe 54 is equipped with a regulating valve 56, and the three branch pipes 54 on the same mounting housing 8 are connected to the main pipe 57, which is connected to a bidirectional air pump 59 located inside the mounting housing 8. The entire system is equipped with two air pumps 59, with the left and right three-probe groups supplying and evacuating air independently respectively. The branch pipes 54 are flexible air tubes with bending capabilities and have a margin of safety near the second ball 53 to avoid restricting the rotation of the second ball 53.

[0079] Each piston rod 55 is equipped with a displacement sensor, and the main pipe 57 is equipped with a pressure sensor. The displacement sensor is used to detect the axial position of the piston rod 55 relative to the air chamber 58, and the pressure sensor is used to detect the supply or suction pressure of the three air chambers 58 in the same group. The regulating valve 56 can change the gas flow rate of the three branch pipes 54 respectively. The processing unit 11 adjusts the three regulating valves 56 according to the displacement feedback, so that the common air source distributes the flow rate according to the skin reaction force and motion resistance of each probe. This can compensate for the load difference of the three pneumatic branches and avoid the inconsistency of the retraction distance of the three probes caused by relying solely on the common pressure.

[0080] The monitoring component 7 is located outside the corresponding probe component 6 and includes a cylinder 71, an annular back plate 72, and a contact switch 73. A rubber ring 711 is provided at the end of the cylinder 71 facing the skin. The cylinder 71 is sleeved and slidably connected to the outside of the probe component 6, the annular back plate 72 is connected to the outside of the probe component 6, and the contact switch 73 is connected to the annular back plate 72. Each monitoring component 7 is provided with one contact switch 73.

[0081] The rear end of the cylinder 71 is in direct contact with the trigger end of the contact switch 73. When there is no skin pressure, the force applied by the cylinder 71 is insufficient to trigger the contact switch 73; after the rubber ring 711 forms complete contact with the skin, the skin's reaction force is transmitted to the contact switch 73 through the rubber ring 711 and the cylinder 71, outputting a skin-touch signal when the trigger pressure is reached. After the external pressure is released, the contact switch 73 releases the trigger using its own elastic stroke, without the need for a separate reset element for the cylinder 71.

[0082] A rubber ring 711 surrounds the light-emitting and light-receiving areas of the probe assembly 6 without obstructing the light path, and is made of a flexible material to adapt to the local contours of the skin. By triggering the contact switch 73 with a specified contact pressure, the "whether it is in contact with the skin" can be changed from a simple reliance on light intensity to an independent mechanical state, reducing the possibility of misjudgment caused by hair obstruction, changes in ambient light, or contamination of the probe window.

[0083] The triggering force of the contact switch 73 is preferably 0.05N to 0.3N, and the compression of the rubber ring 711 under this triggering force is preferably 0.3mm to 1.5mm, so that the rubber ring 711 forms a complete fit along the circumference rather than only forming point contact in a local area. After the contact switch 73 is triggered, if it continues to vibrate or releases the trigger within a set time, the processing unit 11 determines that the fit of the corresponding probe assembly 6 is unstable, and prevents the detection data of the corresponding time period from being included in subsequent calculations.

[0084] In actual use, first, the six piston rods 55 are in the retracted state and the measuring light and PBM light are turned off. The operator opens the two contact ends 22 and puts the elastic element 21 on the neck, so that the two mounting shells 8 are located on the left and right sides of the back of the neck; after releasing, the elastic element 21 clamps the neck with the restoring force, and the anti-slip pad 23 restricts the overall slippage.

[0085] Then, one of the mounting shells 8 is positioned. The operator releases the locking between the first arc-shaped shell 33 and the second arc-shaped shell 34, adjusts the first ball 31 to determine the orientation of the entire three-probe assembly, and then presses the two arc-shaped shells together. The processing unit 11 controls the micro motor 41 to drive the block 43 and the mounting shell 8 close to the neck, and stops the micro motor 41 after entering the effective pneumatic stroke. At this time, the three electromagnets 52 remain unenergized, allowing the three second balls 53 to rotate independently.

[0086] The processing unit 11 controls the air pump 59 to deliver air in the forward direction and adjusts the three regulating valves 56 according to the feedback from the three displacement sensors, so that the three piston rods 55 drive the probe assembly 6 to gradually approach the skin. After a certain rubber ring 711 first contacts the skin and the corresponding contact switch 73 is stably triggered, the processing unit 11 controls the corresponding electromagnet 52 to be energized, locking the second ball 53; the remaining second balls 53 that have not yet been placed on the skin continue to remain in a rotatable state until the corresponding contact switches 73 are triggered in sequence and locking is completed.

[0087] By employing a method of locking each probe individually and confirming the connection of all three probes in the same group, the probe that first contacts the skin can maintain its current tilt angle while allowing the other probes to continue adapting to the curvature of their respective positions. Only after all three contact switches 73 are stably triggered, all three second balls 53 are locked, the pressure of the main tube 57 is within the allowable range, and the optical quality is qualified, does the processing unit 11 determine that the group of three probes is in an effective contact state.

[0088] The processing unit 11 reads the current positions of the three displacement sensors and records them as the contact reference positions of the three piston rods 55. These three contact reference positions are not common absolute positions, but rather independent positions formed by the three probes adapting to their respective skin positions. Therefore, even if the three contact positions are not on the same plane, retraction and re-application can be performed using their respective reference positions.

[0089] When it is necessary to move the probe away from the skin, the processing unit 11 first shuts off the measurement light and PBM light of the corresponding three-probe group, and then controls the air pump 59 to draw air. Negative pressure is applied to the three air chambers 58, causing the three piston rods 55 to retract the probe assembly 6. Let the three contact reference positions be x... 10 x 20 and x 30 The current positions during the retraction process are x1, x2, and x3, respectively. The processing unit 11 takes the contact reference position of each probe assembly 6 as the starting point, controls each piston rod 55 to retract by the same predetermined distance, and dynamically adjusts the corresponding regulating valve 56 according to the position difference, so that the three retraction amounts reach the target synchronously and the difference between the maximum and minimum values ​​is within the allowable range.

[0090] The predetermined retraction distance is preferably 0.5mm to 3mm. During the retraction process, the orientations of the first sphere 31, the mounting shell 8, and the second sphere 53 remain unchanged to reduce the continuous impact of probe contact pressure on the local perfusion state and to retain a repeatable geometric reference for subsequent re-adhesion. After the retraction is completed and the device returns to the adhesion reference position, the processing unit 11 restarts the measurement light and performs baseline measurement; if the change in the optical baseline relative to the baseline before retraction exceeds a preset threshold, the adhesion confirmation and baseline measurement are re-executed, and the relevant data is not included in the three-probe differential calculation.

[0091] When the retraction of a piston rod 55 is too large, the processing unit 11 reduces the opening of the corresponding regulating valve 56 or shortens the conduction time; when the retraction is too small, it increases the opening of the corresponding regulating valve 56 or extends the conduction time. When all three retraction amounts reach the predetermined retraction distance and the difference between the maximum and minimum values ​​is within the allowable range, the air pump 59 is stopped and the regulating valve 56 enters the holding state. By performing branch displacement closed-loop control with their respective contact reference positions as the starting point, the three probes can retract the same distance under different initial extension amounts and different loads.

[0092] During the retraction process, the first arc-shaped shell 33 and the second arc-shaped shell 34 remain pressed together, and the orientation of the first sphere 31 remains unchanged; the micro motor 41 stops, and the positions of the block 43 and the mounting shell 8 remain unchanged; the three electromagnets 52 remain energized, and the orientations of the three second spheres 53 and the probe axis remain unchanged. The retraction and reset along the predetermined axis are completed solely by the drive component 5, which can retain the positioning results at three levels: the overall direction, the overall distance, and the tilt angle of a single probe.

[0093] When retesting is required, the processing unit 11 controls the air pump 59 to deliver air in the forward direction and controls the three regulating valves 56 based on feedback from the three displacement sensors, causing the three piston rods 55 to return to their corresponding bonding reference positions along their respective locked axes. After the three contact switches 73 are re-activated and the pressure and optical quality of the main pipe 57 meet the requirements, the effective bonding state is restored. Thus, during the same use, it is possible to repeatedly approach the previously determined skin position, reducing geometric errors caused by complete removal and repositioning.

[0094] The left and right three-probe groups respectively perform positioning, benchmark establishment, detection, and synchronous distance retraction. When the left three-probe group retracts or repositions, the right three-probe group is not required to act simultaneously; the processing unit 11 saves the mechanical and optical states of the two groups respectively, so as to select single-sided, double-sided synchronous or staggered operation according to the detection task.

[0095] During detection or PBM operation, if the contact switch 73 is deactivated or continues to vibrate, the temperature exceeds the limit, the pressure exceeds the allowable range, the piston rod 55 displacement is abnormal, or the optical quality is unqualified, the processing unit 11 stops the measurement light and PBM light output of the corresponding three-probe group and marks the detection signal of the corresponding period as invalid; simultaneously, it stops the forward air supply of the air pump 59 and controls the air pump 59 to extract air according to the type of abnormality, so that the three piston rods 55 retract to the safe position together. The above abnormalities are all treated as independent safety interlocking conditions, and stopping the light output and retraction action take precedence over subsequent fault diagnosis. By making the abnormal state act simultaneously on the data validity, the light output allowable state, and the mechanical position, it is possible to prevent invalid measurements from continuing to drive PBM adjustment.

[0096] When the micro motor 41 is still working, the first sphere 31 is not locked, the second sphere 53 is not locked, or the air pressure is unstable, the processing unit 11 maintains the PBM light output disabled state. In the event of a power outage, all light output is stopped; after power is restored, the processing unit 11 first checks the contact, displacement, pressure, electromagnetic locking, and air pump status, then prioritizes controlling the air pump 59 to draw air, causing the probe to retract to a safe position. Only after the retraction is completed and the above status is confirmed to be normal is the bonding process allowed to resume; only after re-establishing the bonding reference position and completing the optical baseline check is the detection or PBM output state allowed.

[0097] In an alternative embodiment, the air pump 59 can be a reversible air pump, or two miniature pumps that perform the functions of supplying and evacuating air respectively; the regulating valve 56 can be a proportional regulating valve or a high-speed switching valve; the displacement sensor can be a magnetic, inductive, or photoelectric detection structure; and the contact switch 73 can be a micro switch or a pressure switch with a specified trigger pressure. Regardless of the form used, the contact switch 73 confirms the skin contact state, and the displacement of each piston rod 55 relative to its respective contact reference position is used as the basis for synchronous retraction control.

[0098] A frosted surface or friction lining can be provided between the first arc-shaped shell 33 and the second arc-shaped shell 34. The second sphere 53 can be made entirely of magnetic material or partially equipped with magnetic components. The rubber ring 711 can be made as a detachable and replaceable part, and the mounting shell 8 can be equipped with a maintenance cover. The above replacement structure does not change the coordination relationship between the overall orientation adjustment, distance coarse adjustment, single probe tilt angle locking, and synchronous distance retraction.

[0099] The node response, relaxation characteristics, and adjustment parameters output by this system are only used for closed-loop control of the photobiological regulation process and are not directly used as disease diagnosis results. During use, the processing unit 11 limits the light output power, single output dose, skin contact area temperature, and continuous working time within a preset safe range; the wearing position is determined according to the preset adjustment area and usage requirements, avoiding skin areas that are not suitable for continuous light exposure or contact pressure.

[0100] Through the above structure and working process, the system first establishes the neck support position using the wearable component 2, then the overall orientation of the three-probe group is determined by the main adjustment unit 3, the overall distance of the mounting shell 8 is determined by the sub-adjustment unit 4, the second sphere 53 adapts to the local angles of the three contact positions respectively, the skin contact state is confirmed by the monitoring component 7, and the drive component 5 establishes the contact reference and performs synchronous distance retraction. Based on the effective mechanical state, the processing unit 11 performs three-probe rotation detection, witness differential, pulse relaxation identification, and PBM closed-loop adjustment, thereby forming a continuous closed-loop state for probe positioning, contact confirmation, tissue detection, and photobiological adjustment.

[0101] The specific embodiments described above do not constitute a limitation on the scope of protection of this invention. Those skilled in the art should understand that various modifications, combinations, sub-combinations, and substitutions can be made according to design requirements and other factors. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of this invention should be included within the scope of protection of this invention.

Claims

1. A closed-loop regulation system for acupoint fixed-distance withdrawal based on photonic neural coupling, characterized in that, It includes a processor assembly (1), a wearable assembly (2) and six probe assemblies (6), the six probe assemblies (6) being disposed on the wearable assembly (2) and forming two three-probe groups; The probe assembly (6) is used to output detection light to the corresponding tissue node, collect optical response and output PBM light; the processor assembly (1) controls the three probe assemblies (6) in the same three-probe group to output test light pulses to the corresponding tissue node in sequence, and when one of the probe assemblies (6) outputs test light pulse, the other two probe assemblies (6) synchronously collect witness response, remove common mode change in the response of the target tissue node according to the witness response, obtain tissue oxygenation response and oxygen utilization response of each tissue node, and control the corresponding probe assembly (6) to output PBM light according to the tissue oxygenation response and oxygen utilization response and re-collect tissue node response after output.

2. The acupoint fixed-distance withdrawal closed-loop regulation system based on photonic neural coupling according to claim 1, characterized in that, The processor component (1) obtains the relative level of each tissue node, the gradient between nodes, the fluctuation coherence and the propagation delay based on the optical response collected by the two three-probe groups.

3. The acupoint fixed-distance withdrawal closed-loop regulation system based on photonic neural coupling according to claim 1, characterized in that, The probe assembly (6) outputs PBM light according to preset PBM light output parameters, including light output power, single output dose and continuous working time. The processor assembly (1) adjusts the PBM light output parameters according to the response changes of the corresponding tissue node.

4. The acupoint fixed-distance withdrawal closed-loop regulation system based on photonic neural coupling according to claim 1, characterized in that, The processor component (1) obtains the oxygen transport response and oxygen utilization response of the corresponding tissue node based on the relative changes of oxyhemoglobin, deoxyhemoglobin and oxidized cytochrome c oxidase.

5. The acupoint fixed-distance withdrawal closed-loop regulation system based on photonic neural coupling according to claim 4, characterized in that, The two three-probe groups correspond to the target tissue areas on both sides of the back of the neck. The processor component (1) determines the current working node based on the node-specific response, relaxation characteristics and safety margin, and controls the probe component (6) corresponding to the current working node to output PBM light.

6. The acupoint fixed-distance withdrawal closed-loop regulation system based on photonic neural coupling according to claim 1, characterized in that, The processor component (1) compares the node-specific response and relaxation characteristics before and after PBM optical output; When the node-specific response per unit energy remains stable and there are no abnormal temperatures, overshoots, or reverse responses, maintain or adjust the subsequent PBM light output parameters; when there is a decrease in marginal response, an extension of relaxation time, contact changes, or temperature exceeding limits, reduce or stop the PBM light output.

7. The acupoint fixed-distance withdrawal closed-loop regulation system based on photonic neural coupling according to claim 1, characterized in that, The probe assembly (6) employs at least three near-infrared detection wavelengths: At least one detection wavelength is located in the range of 750nm to 780nm; At least one detection wavelength is located in the range of 800nm ​​to 835nm; At least one detection wavelength is located in the range of 840 nm to 860 nm to obtain the relative changes of oxygenated hemoglobin, deoxygenated hemoglobin, and oxidized cytochrome c oxidase.

8. The acupoint fixed-distance withdrawal closed-loop regulation system based on photonic neural coupling according to claim 5, characterized in that, The two three-probe groups can work sequentially, synchronously, or alternately. The processor component (1) saves the contact state and optical baseline of the two three-probe groups respectively, and controls the PBM light output parameters of each probe component (6) in the two three-probe groups respectively.

9. The acupoint fixed-distance withdrawal closed-loop regulation system based on photonic neural coupling according to claim 1, characterized in that, It also includes a monitoring component (7) corresponding to the six probe components (6), the probe components (6) being movable relative to the wearable component (2), the monitoring component (7) being disposed on the outside of the corresponding probe components (6), and being movable relative to the probe components (6) during the process of the probe components (6) being in contact with the skin, so as to generate a corresponding contact signal.

10. The acupoint fixed-distance withdrawal closed-loop regulation system based on photonic neural coupling according to claim 9, characterized in that, The processor component (1) is connected to the probe component (6) and the monitoring component (7) respectively; after all three monitoring components (7) corresponding to the same three-probe group generate stable contact signals, the processor component (1) records the contact position of the three probe components (6) and controls the three probe components (6) to retract the same predetermined distance along their respective contact directions; when the contact signal of any monitoring component (7) is released, the light output of the corresponding three-probe group is stopped.

Images