Method for manufacturing a developing gauze and developing gauze

Abstract

The application provides a preparation method of a developing gauze and the developing gauze. The preparation method of the developing gauze comprises the following operation steps: obtaining gauze; shaping the gauze into a preset shape; putting the shaped gauze and dry powder indocyanine green into a vacuum adsorption tank for vacuum adsorption treatment, so as to fill the dry powder indocyanine green into the pores of the gauze fibers; putting the adsorbed gauze into a centrifugal device for centrifugal separation treatment, so as to remove the dry powder indocyanine green on the surface of the gauze fibers; and obtaining the developing gauze. The dry powder indocyanine green filled in the pores of the gauze fibers will not fall off when contacting with an organ, so that the problem of color loss and pollution of the visual field can be avoided. Meanwhile, compared with the dry powder indocyanine green attached to the surface of the gauze, the dry powder indocyanine green filled in the pores of the gauze fibers is not prone to the problems of uneven development and unstable fluorescence intensity.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a method for preparing a developing gauze and the developing gauze itself. Background Technology

[0002] In laparoscopic minimally invasive surgery, medical gauze is an indispensable medical consumable, mainly used for intraoperative wound hemostasis, exudate absorption, tissue isolation, and instrument cleaning. However, the field of vision in laparoscopic surgery is limited to the range of the laparoscope lens, resulting in a narrow field of view and insufficient depth perception. Traditional medical gauze is pure white, similar in color to the fat and connective tissue in the human abdominal cavity. During surgery, it is easily lost in the abdominal cavity due to manipulation or tissue obstruction. If it is not detected and removed in time after surgery, it can lead to serious complications such as abdominal infection, adhesion, and foreign body reaction, threatening the patient's life and increasing surgical risks and postoperative care burden.

[0003] To address the issue of traditional gauze being easily lost, existing technologies have employed methods that treat the gauze with contrast agents. Indocyanine green (ICG), a near-infrared fluorescent dye, is widely used in intraoperative imaging due to its advantages such as good biocompatibility, strong near-infrared penetration, and clear imaging. However, current gauze imaging solutions based on ICG mostly involve simple impregnation of the gauze with liquid ICG or direct spraying of liquid ICG onto the gauze surface.

[0004] The existing imaging methods described above have significant technical defects and are difficult to adapt to the precise operational requirements of laparoscopic surgery: On the one hand, liquid indocyanine green does not adhere firmly to the gauze surface. After contact with blood and peritoneal exudate during the operation, it is easy to dissolve and fall off, causing the fluorescent dye to diffuse into the surgical field of view. This interferes with key areas such as tissue boundaries and blood vessel orientation in the surgical area, affecting the surgeon's judgment and increasing the difficulty of the operation. On the other hand, liquid indocyanine green can only adhere to the surface of the gauze and cannot penetrate into the gauze fibers. This easily leads to uneven imaging and unstable fluorescence intensity. Moreover, the imaging duration is short, which is difficult to meet the imaging requirements of long-term laparoscopic surgery.

[0005] Therefore, the imaging gauze in the relevant technology has problems such as poor dye adhesion and easy dissolution and detachment by blood and exudate, which can easily contaminate the surgical field and interfere with the identification of tissues and blood vessels. At the same time, the dye is only distributed on the surface of the gauze, resulting in uneven imaging, unstable fluorescence intensity and short duration, which cannot meet the needs of precise laparoscopic surgery. Summary of the Invention

[0006] This invention provides a method for preparing developing gauze to solve technical problems in related technologies.

[0007] The method for preparing the developing gauze according to an embodiment of the present invention includes the following operations: Obtain gauze; Shape the gauze into the preset shape; The shaped gauze and dry powdered indocyanine green were placed in a vacuum adsorption tank for vacuum adsorption treatment to fill the pores of the gauze fibers with dry powdered indocyanine green. The adsorbed gauze is placed in a centrifuge for centrifugal separation to remove the dry powdery indocyanine green from the surface of the gauze fibers. The developing gauze was obtained.

[0008] Understandably, the dry powdered indocyanine green filling the pores of the gauze fibers will not detach upon contact with organs, thus avoiding color fading and contamination of the field of vision. This effectively reduces intraoperative visual interference, lowers the operational difficulty for medical staff, and improves surgical precision and efficiency, making it particularly suitable for tissue localization and identification in delicate surgical scenarios. Furthermore, compared to attaching the dry powdered indocyanine green to the surface of the gauze, filling the pores of the gauze fibers with dry powdered indocyanine green reduces the likelihood of uneven imaging and unstable fluorescence intensity. This ensures consistent fluorescence signal intensity and clear imaging boundaries across all areas of the gauze, guaranteeing accurate identification of the gauze position during surgery and preventing surgical errors due to imaging deviations, further enhancing surgical safety.

[0009] Furthermore, the pore-filling method allows indocyanine green to form a stable bond with gauze fibers, which not only prevents the loss of fluorescent material due to friction or contact with body fluids during surgery, but also extends the effective imaging time to meet the imaging needs of long-term surgeries. Centrifugation removes surface powder, which avoids overexposure of fluorescence and background interference caused by excess indocyanine green, reduces waste of fluorescent material, lowers product preparation costs, and eliminates tissue irritation or adverse reactions that may be caused by surface powder shedding, thus improving product biocompatibility.

[0010] In some embodiments, the dry powdered indocyanine green has a particle size of 5-20 μm and a purity of ≥99%.

[0011] In some embodiments, during the vacuum adsorption process, the pressure inside the vacuum adsorption tank is -0.08 to -0.09 MPa; the temperature inside the vacuum adsorption tank is 25-40°C; and the vacuum adsorption time is 30-60 min.

[0012] In some embodiments, during the centrifugation process, the centrifugation speed is 500-800 r / min and the centrifugation time is 3-5 min.

[0013] In some embodiments, the indocyanine green loading of the developing gauze is 0.3-1.5 wt%.

[0014] In some embodiments of the present invention, the developing process further includes sterilizing the centrifuged gauze.

[0015] In some embodiments, the gauze obtained during the process of obtaining the gauze is white degreased cotton gauze.

[0016] In some embodiments, during the process of shaping the gauze into a preset shape, the gauze is shaped into a rectangle, and the length of the shaped gauze is 10~15cm, the width is 1~2cm, and the thickness is 1~2mm.

[0017] In some embodiments, the gauze obtained during the process of obtaining the gauze is dark green degreased cotton gauze.

[0018] In some embodiments, during the process of shaping the gauze into a preset shape, the gauze is shaped into an equilateral triangle, and the side length of the shaped gauze is 5~8cm and the thickness is 1~2mm.

[0019] In some embodiments, after the gauze is shaped into a preset shape, it is calendered.

[0020] In some embodiments, a developing element is embedded in the acquired gauze, the developing element being used for developing under radiographic imaging conditions.

[0021] In some embodiments, the developing element is a developing line, which extends along a predetermined direction and is disposed within the gauze.

[0022] In some embodiments, the developing line is a barium sulfate developing line, a tungsten alloy developing line, or a platinum-iridium alloy developing line.

[0023] In some embodiments, the diameter of the developing line is 0.1 to 0.3 mm.

[0024] The present invention also provides a developing gauze.

[0025] The developing gauze in this embodiment of the invention is a white degreased cotton gauze, which has fiber pores and is filled with indocyanine green.

[0026] The present invention also provides a developing gauze.

[0027] The developing gauze in this embodiment of the invention is a dark green degreased cotton gauze, which has fiber pores and is filled with indocyanine green.

[0028] In some embodiments, the developing gauze has a built-in developing element for developing under radiographic imaging conditions.

[0029] In some embodiments, the developing element is a developing line, which extends along a predetermined direction and is disposed within the gauze.

[0030] In some embodiments, the developing line is a barium sulfate developing line, a tungsten alloy developing line, or a platinum-iridium alloy developing line.

[0031] In some embodiments, the diameter of the developing line is 0.1 to 0.3 mm. Attached Figure Description

[0032] To more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the description of the embodiments of the present invention will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0033] Figure 1 This is a partial enlarged view of the developing gauze prepared by the developing gauze preparation method of this embodiment of the invention; Figure 2 This is a schematic diagram of the structure of the developing gauze according to an embodiment of the present invention; Figure 3 This is a schematic diagram of the structure of the developing gauze according to another embodiment of the present invention; In the picture: 100. Developing gauze; 1. Developing element; Detailed Implementation To make the technical problems solved, the technical solutions, and the beneficial effects of this invention clearer, the invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

[0034] In the description of this invention, it should be understood that the terms "longitudinal," "radial," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicating orientation or positional relationships, are based on the orientation or positional relationships shown in the accompanying drawings and are only for the convenience of describing the invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of the invention. In the description of this invention, unless otherwise stated, "a plurality of" means two or more.

[0035] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal encapsulation of two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0036] This invention provides a method for preparing developing gauze 100.

[0037] The preparation method of the developing gauze 100 in this embodiment of the invention includes the following steps: Obtain gauze; Shape the gauze into the preset shape; The shaped gauze and dry powdered indocyanine green were placed in a vacuum adsorption tank for vacuum adsorption treatment to fill the pores of the gauze fibers with dry powdered indocyanine green. The adsorbed gauze is placed in a centrifuge for centrifugal separation to remove the dry powdery indocyanine green from the surface of the gauze fibers. 100 pieces of developing gauze were obtained.

[0038] The method for preparing the developing gauze 100 in this embodiment of the invention involves placing gauze and dry powdered indocyanine green into a vacuum adsorption tank for vacuum adsorption treatment, so that the dry powdered indocyanine green fills the pores of the gauze fibers. At the same time, the adsorbed gauze is placed into a centrifuge for centrifugal separation treatment to remove the dry powdered indocyanine green from the surface of the gauze fibers, thereby obtaining the developing gauze 100.

[0039] Understandably, the dry powdered indocyanine green filling the pores of the gauze fibers will not detach upon contact with organs, thus avoiding color fading and contamination of the field of vision. This effectively reduces intraoperative visual interference, lowers the operational difficulty for medical staff, and improves surgical precision and efficiency, making it particularly suitable for tissue localization and identification in delicate surgical scenarios. Furthermore, compared to attaching the dry powdered indocyanine green to the surface of the gauze, filling the pores of the gauze fibers with dry powdered indocyanine green reduces the likelihood of uneven imaging and unstable fluorescence intensity. This ensures consistent fluorescence signal intensity and clear imaging boundaries across all areas of the gauze, guaranteeing accurate identification of the gauze position during surgery and preventing surgical errors due to imaging deviations, further enhancing surgical safety.

[0040] Furthermore, the pore-filling method allows indocyanine green to form a stable bond with gauze fibers, which not only prevents the loss of fluorescent material due to friction or contact with body fluids during surgery, but also extends the effective imaging time to meet the imaging needs of long-term surgeries. Centrifugation removes surface powder, which avoids overexposure of fluorescence and background interference caused by excess indocyanine green, reduces waste of fluorescent material, lowers product preparation costs, and eliminates tissue irritation or adverse reactions that may be caused by surface powder shedding, thus improving product biocompatibility.

[0041] In some embodiments, the dry powdered indocyanine green has a particle size of 5-20 μm and a purity of ≥99%.

[0042] Preferably, the particle size of the dry powdered indocyanine green is 5μm, 6μm, 7μm, 8μm, 9μm, 10μm, 11μm, 12μm, 13μm, 14μm, 15μm, 16μm, 17μm, 18μm, 19μm, or 20μm.

[0043] Understandably, a particle size of 5–20 μm is considered moderate. It avoids localized agglomeration and deposition due to excessively large particle size, and also prevents excessively fine particle size from causing dispersion, drift, or rapid diffusion and loss. This particle size range allows indocyanine green to adhere evenly and distribute stably on gauze or tissue surfaces, preventing excessively high or low local concentrations and ensuring a uniform and continuous fluorescence signal. Meanwhile, setting the purity of dry powdered indocyanine green to ≥99% can significantly reduce impurity content. Since impurities often possess self-fluorescence or absorption properties, they can generate non-specific background fluorescence and stray light, interfering with the identification of the target imaging area. Setting the purity of dry powdered indocyanine green to high significantly improves the signal-to-noise ratio, making the imaging boundary clearer. Furthermore, high-purity indocyanine green avoids potential biocompatibility risks caused by impurities, better meeting the safety requirements of medical consumables.

[0044] In some embodiments, during the vacuum adsorption process, the pressure inside the vacuum adsorption tank is -0.08 to -0.09 MPa; the temperature inside the vacuum adsorption tank is 25-40°C; and the vacuum adsorption time is 30-60 min.

[0045] Preferably, the pressure inside the vacuum adsorption tank is -0.081MPa, -0.082MPa, -0.083MPa, -0.084MPa, -0.085MPa, -0.086MPa, -0.087MPa, -0.088MPa, -0.089MPa, or -0.09MPa.

[0046] Preferably, the temperature inside the vacuum adsorption tank is 25°C, 30°C, 35°C or 40°C.

[0047] Preferably, the vacuum adsorption time is 30 min, 35 min, 40 min, 45 min, 50 min, 55 min, or 60 min.

[0048] Understandably, if the pressure is below -0.08 MPa, insufficient pressure difference will lead to insufficient powder penetration, low loading and uneven distribution, affecting the fluorescence imaging effect; if the pressure is above -0.09 MPa, excessive negative pressure will easily cause the gauze fiber pores to collapse and the structure to deform, and may also lead to excessive powder adsorption or local aggregation, increasing the risk of falling off during the operation.

[0049] When the temperature is below 25℃, the powder has poor flowability, slow molecular movement, reduced penetration efficiency, and prolonged adsorption time. When the temperature is above 40℃, on the one hand, it will accelerate the aging of cotton fibers, causing the gauze to become hard and brittle, affecting the feel of use; on the other hand, it may cause partial thermal degradation of indocyanine green molecules, reducing fluorescence intensity and stability.

[0050] When the adsorption time is less than 30 minutes, the powder has not fully penetrated and only adheres to the fiber surface. The subsequent centrifugation process to remove free powder will cause a large amount of powder to fall off, resulting in insufficient load and easy dispersal during the operation. When the adsorption time is longer than 60 minutes, the load is already saturated. Extending the time will not significantly improve the adsorption effect, but will instead reduce production efficiency, increase energy consumption, and may even cause local accumulation due to the powder circulating in the tank for a long time.

[0051] By setting the above parameters to the above range, the developing powder can be fully and evenly penetrated into the pores of the gauze fibers while ensuring the integrity of the gauze structure, thus obtaining a stable and appropriate load. This ensures a clear and stable fluorescent imaging effect, avoids excessive powder shedding that could lead to intraoperative risks, and protects the physical properties of the gauze fibers from damage, maintaining the fluorescence stability of indocyanine green, thus balancing production efficiency and product performance.

[0052] In some embodiments, during the centrifugation process, the centrifugation speed is 500-800 r / min and the centrifugation time is 3-5 min.

[0053] Preferably, the centrifugation speed is 500 r / min, 520 r / min, 540 r / min, 560 r / min, 580 r / min, 600 r / min, 620 r / min, 640 r / min, 660 r / min, 680 r / min, 700 r / min, 720 r / min, 740 r / min, 760 r / min, 780 r / min or 800 r / min.

[0054] Preferably, the centrifugation time is 3 min, 3.5 min, 4 min, 4.5 min, or 5 min.

[0055] Understandably, when the rotation speed is below 500 r / min, the centrifugal force is too weak, and the surface powder cannot be completely removed, which can easily cause powder to fall off during the operation and contaminate the surgical field. When the rotation speed is above 800 r / min, the centrifugal force is too large, which can easily cause the gauze to fray, the fibers to loosen and break, and at the same time, it will shake out the indocyanine green that has been anchored inside the fibers, reducing the effective load and destroying the stability of fluorescence imaging.

[0056] When the centrifugation time is less than 3 minutes, the action time is insufficient, and a lot of powder remains on the edges and folds of the gauze. This powder is very easy to fall off during subsequent sterilization and clinical use, interfering with the surgical field of vision and causing tissue staining. When the centrifugation time exceeds 5 minutes, the long-term continuous low-speed centrifugation has no additional powder removal effect, increases production time and energy consumption, and is also prone to causing the gauze to be stacked, squeezed and deformed, affecting the flat shape of the finished product. At the same time, there is a risk of shaking off the internally adsorbed fluorescent powder, which greatly reduces the product qualification rate.

[0057] By setting the above parameters to the above range, it is possible to fully remove the free powder remaining on the surface while ensuring the integrity and flatness of the gauze structure, and at the same time retain the indocyanine green imaging component anchored inside the gauze fibers to the greatest extent. This avoids the risk of powder falling and contaminating the surgical area during clinical use, and ensures that the imaging gauze 100 has a stable and reliable fluorescence imaging effect.

[0058] In some embodiments, the indocyanine green loading of the developing gauze 100 is 0.3-1.5 wt%.

[0059] Preferably, the indocyanine green loading of the developing gauze 100 is 0.3wt%, 0.4wt%, 0.5wt%, 0.6wt%, 0.7wt%, 0.8wt%, 0.9wt%, 1.0wt%, 1.1wt%, 1.2wt%, 1.3wt%, 1.4wt%, or 1.5wt%.

[0060] It is understandable that when the loading is less than 0.3wt%, the indocyanine green content attached to the gauze is too low, resulting in weak fluorescence brightness and poor imaging recognition under fluorescence laparoscopic imaging conditions. This fails to meet the requirements for intraoperative gap identification and intraoperative count identification, and does not meet the clinical fluorescence imaging standards.

[0061] When the loading exceeds 1.5wt%, excessive indocyanine green will fill the gaps between gauze fibers, causing blockage of the gauze fiber pores. This significantly reduces the original absorbency, softness, and breathability of the gauze, making the gauze texture harder. This is not conducive to intraoperative clamping operations, wound compression hemostasis, and tissue adhesion and protection. At the same time, excessive powder is prone to poor adhesion, increasing the risk of powder falling off during surgery and contaminating abdominal tissues, thus increasing the safety risks in clinical use.

[0062] By setting the above parameters to the above range, the physical properties of the gauze itself can be preserved while ensuring the fluorescence imaging effect. This satisfies the clinical needs of intraoperative imaging and identification, while maintaining the gauze's good water absorption, breathability, and softness, avoiding powder shedding and contamination of the wound, balancing imaging effect and safety of use, and adapting to the clinical requirements of abdominal surgery.

[0063] In some embodiments, the preparation method of the developing gauze 100 of the present invention further includes the following operation: sterilizing the gauze after centrifugation.

[0064] In some embodiments, the gauze obtained during the process of obtaining the gauze is white degreased cotton gauze.

[0065] It is understood that by setting the obtained gauze as white degreased cotton gauze, the developing gauze 100 of this embodiment of the invention can be used for white balance calibration. For example, in laparoscopic surgery, after the fluorescence laparoscopic device is turned on, a white conventional gauze is sent into the abdominal cavity, and the white balance calibration function built into the device is used to complete the calibration with the developing gauze 100 as a reference to ensure accurate fluorescence imaging.

[0066] In some embodiments, during the process of shaping the gauze into a preset shape, the gauze is shaped into a rectangle, and the length of the shaped gauze is 10-15cm, the width is 1-2cm, and the thickness is 1-2mm.

[0067] Preferably, the length of the shaped gauze is 10cm, 11cm, 12cm, 13cm, 14cm or 15cm.

[0068] Preferably, the width is 1.0cm, 1.1cm, 1.2cm, 1.3cm, 1.4cm, 1.5cm, 1.6cm, 1.7cm, 1.8cm, 1.9cm or 2.0cm.

[0069] Preferably, the thickness is 1.0cm, 1.1cm, 1.2cm, 1.3cm, 1.4cm, 1.5cm, 1.6cm, 1.7cm, 1.8cm, 1.9cm or 2.0cm.

[0070] Understandably, gauze shorter than 10cm is too short to operate on, inconvenient to hold, and prone to slipping and loss during surgery; gauze longer than 15cm is too long, making it difficult to insert via the trocar, prone to bending and entanglement, occupying abdominal operating space, and affecting the surgical field of vision. Gauze less than 1cm wide is too narrow, with a small contact area, resulting in poor hemostasis, wiping, and calibration effects; gauze wider than 2cm is too wide, making it difficult to pass smoothly through the conventional surgical trocar, limiting its use, and its large size can obstruct the surgical field of vision. Gauze less than 1mm thick is too thin, with insufficient overall strength, prone to breakage during surgery, and fragments left in the abdominal cavity pose a safety hazard; gauze thicker than 2mm is too thick and stiff, reducing flexibility, making it difficult to clamp and bend, with a stiff feel, not conducive to fitting into cavity gaps, and significantly increasing the overall volume, hindering flexible use during surgery.

[0071] Therefore, setting the above parameters to the above range can not only adapt to most conventional trocar sizes and be smoothly inserted into the surgical cavity, but also ensure sufficient contact area and structural strength to meet the needs of intraoperative hemostasis, wiping, and positioning calibration. At the same time, it avoids occupying too much operating space and obstructing the field of vision, reduces the risk of gauze slippage, damage, and bending during the operation, and improves the safety and smoothness of the surgical operation.

[0072] In some embodiments, the gauze obtained during the process of obtaining the gauze is dark green degreased cotton gauze.

[0073] The radiopaque 100 of this embodiment of the invention is made of dark green degreased cotton gauze, which enables the radiopaque 100 of this embodiment of the invention to be used for intraoperative navigation. For example, when the radiopaque 100 of this embodiment of the invention is inserted into the abdominal cavity, it can emit clear fluorescence under fluorescence laparoscopy and be used as a navigation marker for interstitial spaces.

[0074] In some embodiments, during the process of shaping the gauze into a preset shape, the gauze is shaped into an equilateral triangle, and the side length of the shaped gauze is 5~8cm and the thickness is 1~2mm.

[0075] Preferably, the side length of the shaped gauze is 5cm, 5.5cm, 6cm, 6.5cm, 7cm, 7.5cm, or 8cm.

[0076] Preferably, the thickness is 1.0cm, 1.1cm, 1.2cm, 1.3cm, 1.4cm, 1.5cm, 1.6cm, 1.7cm, 1.8cm, 1.9cm or 2.0cm.

[0077] Understandably, when the side length is less than 5cm, the effective area is too small, the navigation and positioning range in the interstitial space is limited, and the hemostasis and isolation protection effects are weak. When the side length is greater than 8cm, the overall size is too large, and even after folding, it is still not easy to puncture and insert smoothly. It is easy to obstruct the surgical field during operation and is also more likely to become stuck in the gaps between organs, increasing the difficulty of tracing and identifying residual tissue. Gauze with a thickness of less than 1mm is too thin, and the overall strength is insufficient. It is easy to break and tear during operation, and the fragments left in the abdominal cavity pose a safety hazard. Gauze with a thickness of more than 2mm is too thick and stiff, and its flexibility is reduced. It is difficult to clamp and bend, and it feels stiff to the touch. It is not conducive to fitting the gaps in the cavity, and at the same time, it significantly increases the overall volume, which is not conducive to flexible use during operation.

[0078] Therefore, by setting the above parameters to the above range, the radiopaque gauze 100 can maintain good flexibility while ensuring sufficient effective area and structural strength. It can be smoothly inserted into the surgical site through the puncture channel to fully play the role of hemostasis and isolation protection, without excessively obstructing the surgical field of vision, reducing the risk of gauze entrapment, and adapting to the needs of most minimally invasive surgeries.

[0079] In some embodiments, after the gauze is shaped into a preset shape, it is calendered.

[0080] It is understandable that when light is incident on uncalendered gauze, the loose and disordered fiber structure will produce a lot of diffuse reflection, resulting in obvious reflection and glare. Calendered gauze, on the other hand, has a smooth surface that makes light more directional or weakly reflective, with more concentrated reflected light and less scattering, thereby reducing irregular reflection and glare and achieving an anti-reflective effect.

[0081] In some embodiments, a developing element 1 is embedded in the acquired gauze, the developing element 1 being used for developing under radiographic imaging conditions.

[0082] It is understandable that by embedding the imaging element 1 in the obtained gauze, and the imaging element 1 is used for imaging under radiographic conditions, that is, the imaging element 1 can be visualized under X-ray or CT examination. If it is suspected that the imaging gauze 100 has been left in the body after the operation, it can be quickly confirmed by X-ray or CT examination whether the imaging gauze has been left in the body.

[0083] In some embodiments, the developing element 1 is a developing line, which extends along a predetermined direction and is disposed within the gauze.

[0084] It is understandable that by setting the imaging element 1 as the imaging line and extending it in the gauze along a preset direction, the imaging line can be stably embedded in the gauze without shifting during use. At the same time, it can stably develop during imaging examinations, clearly showing the overall outline of the gauze, which makes it convenient for medical staff to quickly identify and determine whether the gauze has been completely removed after surgery.

[0085] In some embodiments, the developing line is a barium sulfate developing line, a tungsten alloy developing line, or a platinum-iridium alloy developing line.

[0086] It is understandable that by setting the imaging line to barium sulfate imaging line, tungsten alloy imaging line, or platinum-iridium alloy imaging line, these materials can all achieve clear imaging under radiographic imaging conditions. They are also chemically stable and will not react adversely with the gauze itself or human tissue. During surgical use, there will be no issues with material shedding or performance changes, which can meet the safety requirements for surgical use, while ensuring the stability and clarity of imaging, and facilitating postoperative screening and identification.

[0087] In some embodiments, the diameter of the developing line is 0.1 to 0.3 mm.

[0088] Preferably, the diameter of the developing line is 0.10mm, 0.11mm, 0.12mm, 0.13mm, 0.14mm, 0.15mm, 0.16mm, 0.17mm, 0.18mm, 0.19mm, 0.20mm, 0.21mm, 0.22mm, 0.23mm, 0.24mm, 0.25mm, 0.26mm, 0.27mm, 0.28mm, 0.29mm, or 0.30mm.

[0089] It is understandable that if the diameter of the imaging line is too large, it will be difficult to insert it into the gauze; if the diameter of the imaging line is too small, it will affect the imaging effect and lead to a decrease in imaging effect. Therefore, by setting the diameter of the imaging line to the above range, it is possible to ensure clear and stable imaging while reducing the impact of the imaging line on the overall softness of the gauze. It will not cause obvious foreign body sensation in the gauze due to the embedded imaging line, nor will it change the original operation performance of the gauze, making it convenient for normal use during the operation. At the same time, it is easy to stably insert the imaging line into the gauze during the production process.

[0090] The present invention also provides a developing gauze 100.

[0091] The developing gauze 100 in this embodiment of the invention is a white degreased cotton gauze. The white degreased cotton gauze has fiber pores, and indocyanine green is adsorbed and filled in the fiber pores.

[0092] It is understood that the developing gauze 100 in this embodiment of the invention is set as white degreased cotton gauze, so that the developing gauze 100 in this embodiment of the invention can be used for white balance calibration. For example, in laparoscopic surgery, after the fluorescence laparoscopic device is turned on, the developing gauze 100 of this embodiment of the invention is sent into the abdominal cavity, and the white balance calibration function built into the fluorescence laparoscopic device is used as a reference to complete the calibration, so as to ensure accurate fluorescence imaging.

[0093] The present invention also provides a developing gauze 100.

[0094] The developing gauze 100 in this embodiment of the invention is a dark green degreased cotton gauze. The dark green degreased cotton gauze has fiber pores, and indocyanine green is adsorbed and filled in the fiber pores.

[0095] It is understood that the radiopaque 100 of this embodiment of the invention is set as dark green degreased cotton gauze, so that the radiopaque 100 of this embodiment of the invention can be used for intraoperative navigation. For example, when the radiopaque 100 of this embodiment of the invention is inserted into the abdominal cavity, under fluorescence laparoscopy, the radiopaque 100 of this embodiment of the invention can emit clear fluorescence and be used as a navigation marker for interstitial spaces.

[0096] In some embodiments, the developing gauze 100 contains a developing element 1 for developing under radiographic imaging conditions.

[0097] It is understandable that by embedding the developing element 1 inside the developing gauze 100, and the developing element being used for developing under radiographic imaging conditions, that is, the developing element 1 can be developed under X-ray or CT examination. If it is suspected that the developing gauze 100 has been left in the body after the operation, it can be quickly confirmed by X-ray or CT examination whether the developing tongue has been left in the body.

[0098] In some embodiments, the developing element 1 is a developing line, which extends along a predetermined direction and is disposed within the gauze.

[0099] It is understandable that by setting the imaging element 1 as the imaging line and extending it in the gauze along a preset direction, the imaging line can be stably embedded in the gauze without shifting during use. At the same time, it can stably develop during imaging examinations, clearly showing the overall outline of the gauze, which makes it convenient for medical staff to quickly identify and determine whether the gauze has been completely removed after surgery.

[0100] In some embodiments, the developing line is a barium sulfate developing line, a tungsten alloy developing line, or a platinum-iridium alloy developing line.

[0101] It is understandable that by setting the imaging line to barium sulfate imaging line, tungsten alloy imaging line, or platinum-iridium alloy imaging line, these materials can all achieve clear imaging under radiographic imaging conditions. They are also chemically stable and will not react adversely with the gauze itself or human tissue. During surgical use, there will be no issues with material shedding or performance changes, which can meet the safety requirements for surgical use, while ensuring the stability and clarity of imaging, and facilitating postoperative screening and identification.

[0102] In some embodiments, the diameter of the developing line is 0.1 to 0.3 mm.

[0103] Preferably, the diameter of the developing line is 0.10mm, 0.11mm, 0.12mm, 0.13mm, 0.14mm, 0.15mm, 0.16mm, 0.17mm, 0.18mm, 0.19mm, 0.20mm, 0.21mm, 0.22mm, 0.23mm, 0.24mm, 0.25mm, 0.26mm, 0.27mm, 0.28mm, 0.29mm, or 0.30mm.

[0104] It is understandable that if the diameter of the imaging line is too large, it will be difficult to insert it into the gauze; if the diameter of the imaging line is too small, it will affect the imaging effect and lead to a decrease in imaging effect. Therefore, by setting the diameter of the imaging line to the above range, it is possible to ensure clear and stable imaging while reducing the impact of the imaging line on the overall softness of the gauze. It will not cause obvious foreign body sensation in the gauze due to the embedded imaging line, nor will it change the original operation performance of the gauze, making it convenient for normal use during the operation. At the same time, it is easy to stably insert the imaging line into the gauze during the production process.

[0105] The above-described embodiments are only used to illustrate the technical solutions of the present invention, and are not intended to limit it. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention, and should all be included within the protection scope of the present invention.

Claims

1. A method for preparing a developing gauze, characterized in that, This includes the following operations: Obtain gauze; Shape the gauze into the preset shape; The shaped gauze and dry powdered indocyanine green were placed in a vacuum adsorption tank for vacuum adsorption treatment to fill the pores of the gauze fibers with dry powdered indocyanine green. The adsorbed gauze is placed in a centrifuge for centrifugal separation to remove the dry powdery indocyanine green from the surface of the gauze fibers. The developing gauze was obtained.

2. The method for preparing the developing gauze according to claim 1, characterized in that, The dry powder form of indocyanine green has a particle size of 5-20 μm and a purity of ≥99%.

3. The method for preparing the developing gauze according to claim 1, characterized in that, During the vacuum adsorption process, the pressure inside the vacuum adsorption tank is -0.08 to -0.09 MPa; the temperature inside the vacuum adsorption tank is 25-40℃; and the vacuum adsorption time is 30-60 minutes.

4. The method for preparing the developing gauze according to claim 1, characterized in that, During the centrifugation process, the centrifugation speed is 500-800 r / min and the centrifugation time is 3-5 min.

5. The method for preparing the developing gauze according to claim 1, characterized in that, The indocyanine green loading of the developing gauze is 0.3-1.5 wt%.

6. The method for preparing the developing gauze according to claim 1, characterized in that, It also includes the following operation: sterilizing the gauze after centrifugation.

7. The method for preparing the developing gauze according to claim 1, characterized in that, The gauze obtained during the process of acquiring the gauze is white degreased cotton gauze.

8. The method for preparing the developing gauze according to claim 7, characterized in that, During the process of shaping the gauze into the preset shape, the gauze is shaped into a rectangle with a length of 10-15cm, a width of 1-2cm, and a thickness of 1-2mm.

9. The method for preparing the developing gauze according to claim 1, characterized in that, The gauze obtained during the process of acquiring the gauze is dark green degreased cotton gauze.

10. The method for preparing the developing gauze according to claim 9, characterized in that, During the process of shaping the gauze into the preset shape, the gauze is shaped into an equilateral triangle with a side length of 5-8cm and a thickness of 1-2mm.

11. The method for preparing the developing gauze according to claim 9, characterized in that, After shaping the gauze into the preset shape, the gauze is calendered.

12. The method for preparing the developing gauze according to claim 1, characterized in that, A developing element is embedded in the acquired gauze, which is used for developing under radiographic imaging conditions.

13. The method for preparing the developing gauze according to claim 12, characterized in that, The developing element is a developing line, which extends along a preset direction and is disposed within the gauze.

14. The method for preparing the developing gauze according to claim 13, characterized in that, The developing line is a barium sulfate developing line, a tungsten alloy developing line, or a platinum-iridium alloy developing line.

15. The method for preparing the developing gauze according to claim 13, characterized in that, The diameter of the developing line is 0.1 to 0.3 mm.

16. A developing gauze, characterized in that, The developing gauze is white degreased cotton gauze, which has fiber pores, and the fiber pores are adsorbed and filled with indocyanine green.

17. A developing gauze, characterized in that, The developing gauze is a dark green degreased cotton gauze, which has fiber pores, and the fiber pores are adsorbed and filled with indocyanine green.

18. The developing gauze according to claim 16 or 17, characterized in that, The developing gauze contains a developing element, which is used for developing under radiographic imaging conditions.

19. The method for preparing the developing gauze according to claim 18, characterized in that, The developing element is a developing line, which extends along a preset direction and is disposed within the gauze.

20. The method for preparing the developing gauze according to claim 19, characterized in that, The developing line is a barium sulfate developing line, a tungsten alloy developing line, or a platinum-iridium alloy developing line.

21. The method for preparing the developing gauze according to claim 20, characterized in that, The diameter of the developing line is 0.1 to 0.3 mm.

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