An LIS data linkage-based automatic post-processing system for test samples

Abstract

The present application relates to medical test automation, biological sample intelligent management technical field, the present application discloses a kind of based on LIS data linkage's test specimen automation post-processing system, including the specimen post-processing equipment ontology for test specimen sorting, subpackaging, identification and filing, also include: LIS data linkage interactive module, configured to establish the data communication link with hospital LIS system, response staff's custom specimen screening condition preset, the present application breaks through hospital LIS data link, supports composite condition screening and automatically checks data, avoids artificial screening error, realizes specimen processing whole process automation, greatly improves efficiency, reduces artificial error.Adaptive pipetting unit precision reaches ±0.05ml, cooperate with standardization centrifugal seal cap, guarantee sample uniformity and stability.Special unique identification label is matched with low temperature, does not lose effectiveness in long-term low-temperature storage.System retains tamper-proof log, multidimensional traceability, strong compliance;Compatible mainstream test system.

Description

Technical Field

[0001] This invention relates to the fields of medical testing automation and intelligent management of biological samples, specifically an automated post-processing system for test specimens based on LIS data linkage. Background Technology

[0002] Hospital laboratories generate a massive number of blood test specimens every day. For scenarios such as tracing the source of difficult cases, clinical research on special diseases, and preservation of scientific research samples, it is necessary to screen, aliquot, label, and preserve specimens that meet specific disease characteristics or detection thresholds at low temperatures. This is the foundation for the standardization of clinical laboratory work and the operation of biobanks.

[0003] Currently, the entire specimen post-processing process relies heavily on manual operation. Staff need to log into the LIS system to manually retrieve the target specimen and record its number, then go to the specimen storage area to find and sort them one by one; then manually centrifuge and manually pipette 2ml of serum or plasma into cryovials and manually seal them; finally, enter the information, print labels and manually affix them, store them in a -80℃ freezer and register and archive them.

[0004] The aforementioned manual process has several drawbacks. In the screening stage, manual retrieval is prone to omissions, incorrect selections, and statistical errors. In the dispensing stage, manual pipetting has significant volumetric errors and is susceptible to sample contamination, hemolysis, and leakage. In the labeling stage, manual data entry, printing, and labeling can lead to information errors, label detachment, and mismatches between specimens and labels. Furthermore, the lack of standardized work logs throughout the process makes specimen information untraceable and hinders standardized management after archiving. Existing semi-automatic equipment can only perform single dispensing or labeling functions and cannot integrate with the LIS system to complete intelligent screening and a closed-loop process. Therefore, we propose an automated post-processing system for laboratory specimens based on LIS data linkage to address these problems. Summary of the Invention

[0005] To address the shortcomings of existing technologies, this invention provides an automated post-processing system for test specimens based on LIS data linkage, which solves problems such as reliance on manual screening and packaging, error-prone data matching, sample standardization deviation, low-temperature label failure, lack of effective traceability throughout the process, and weak equipment compatibility in existing specimen post-processing.

[0006] To achieve the above objectives, the present invention provides the following technical solution: an automated post-processing system for laboratory specimens based on LIS data linkage, comprising a specimen post-processing equipment body for sorting, packaging, labeling, and archiving laboratory specimens, and further comprising:

[0007] The LIS data linkage and interaction module is configured to establish a data communication link with the hospital's LIS system, respond to the custom specimen screening conditions preset by the staff, retrieve, verify and store patient information and specimen information that meet the screening conditions from the LIS system, and generate a target specimen processing list.

[0008] The intelligent specimen positioning and picking module is connected to the LIS data linkage and interaction module, receives the target specimen processing list, locates and verifies the target blood specimens after completion by barcode comparison, and performs the sorting, picking and transportation of the target specimens.

[0009] An automated specimen dispensing and packaging module is connected to the specimen output station of the intelligent specimen positioning and picking module. It is used to perform centrifugation on the target blood specimen delivered to the station to obtain serum or plasma samples, quantitatively aspirate a predetermined volume of serum or plasma samples and transfer them to cryovials, and perform capping operations on the cryovials.

[0010] The intelligent labeling and printing module is signal-connected to both the LIS data linkage and interaction module and the automated specimen dispensing and packaging module. It is used to acquire patient information and test data for the corresponding specimen and generate a unique specimen serial number, perform label printing, and affix the printed label to the outer wall of the cryotube; and

[0011] The specimen archiving management module is communicatively connected to the intelligent labeling and printing module. It is used to scan the labels on the cryovials to complete the specimen information entry and archiving storage, and generate a full-process processing log.

[0012] This invention provides an automated post-processing method for laboratory specimens based on LIS data linkage, comprising the following steps:

[0013] S1. Input and save the custom specimen screening conditions through the LIS data linkage interaction module, and issue a system start command after confirmation.

[0014] S2. The LIS data linkage and interaction module retrieves matching patient data and specimen data from the hospital's LIS system, and generates a target specimen processing list after data verification.

[0015] S3. The intelligent specimen positioning and picking module identifies the target blood specimen by barcode comparison according to the target specimen processing list, and performs sorting, picking and transporting to the packaging station.

[0016] S4. The automated specimen dispensing and packaging module centrifuges the target blood specimen to obtain serum or plasma samples, quantitatively aspirates a predetermined volume of sample and transfers it to a cryotube, and seals the cryotube.

[0017] S5. The intelligent labeling and printing module acquires the patient information and test data of the corresponding specimen and generates a unique specimen serial number, performs label printing, and affixes the label to the outer wall of the cryotube.

[0018] S6. The specimen archiving management module scans the label to automatically archive the specimen information and generate a processing log.

[0019] Beneficial effects

[0020] This invention provides an automated post-processing system for laboratory specimens based on LIS data linkage. Compared with existing technologies, it has the following advantages:

[0021] This automated post-processing system for laboratory specimens, based on LIS data linkage, establishes a data interaction link with the hospital's LIS system. It supports customized multi-dimensional composite screening conditions and is equipped with multiple data verification mechanisms to automatically clean abnormal and duplicate data, generating an accurate list of target specimens. This eliminates the problems of missed or incorrect selection caused by manual retrieval and handwritten numbering from the source. The entire process of specimen screening, sorting, packaging, labeling, and archiving is automated and closed-loop, eliminating the need for manual intervention in core procedures. This significantly improves batch processing efficiency and reduces the manpower input and human operation risks in the laboratory.

[0022] Equipped with an adaptive pipetting unit featuring a viscosity compensation algorithm, the pipetting accuracy is controlled within ±0.05ml. Combined with standardized centrifugation and an adaptive pressure cap structure, it unifies the volume and sealing standards of all retained samples, effectively avoiding problems such as volume deviation from manual pipetting, hemolysis of specimens, and sample leakage and contamination, ensuring the uniformity of scientific research retained samples and the stability of long-term storage.

[0023] The equipment is equipped with a low-temperature weather-resistant printing component, which automatically generates standardized traceability labels with unique serial numbers. It is suitable for long-term storage at ultra-low temperatures of -80℃, and the labels do not fade, fall off, or become invalid. The adaptive labeling mechanism ensures that the labels are flat and adhered, completely solving the pain points of traditional paper labels failing at low temperatures and mismatch between specimens and information.

[0024] The system retains an unalterable electronic operation log throughout the entire process, supports one-click traceability of multiple dimensions such as medical record number, specimen number, and test items, and automatically generates storage ledgers for ultra-low temperature freezers, fully meeting the compliance traceability supervision requirements of biobanks and hospital laboratories.

[0025] The system is equipped with a universal and compatible interface that can connect to mainstream LIS and specimen management systems. It also supports two operating modes: single-machine small-batch and pipeline-scale operation, making it suitable for different usage scenarios in hospitals at all levels and research sample banks. The equipment has stronger versatility and expandability. Attached Figure Description

[0026] Figure 1This is a block diagram of an automated post-processing system for test specimens based on LIS data linkage according to the present invention.

[0027] Figure 2 This is a flowchart of an automated post-processing method for test specimens based on LIS data linkage according to the present invention. Detailed Implementation

[0028] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0029] like Figure 1 As shown:

[0030] An automated post-processing system for laboratory specimens based on LIS data linkage includes a specimen post-processing device body, which includes an LIS data linkage interaction module, an intelligent specimen positioning and picking module, an automated specimen dispensing and packaging module, an intelligent labeling and printing module, and a specimen archiving and management module. The system is also equipped with a multi-device compatible interface, supporting both stand-alone operation and batch production line operation modes.

[0031] The LIS data linkage and interaction module establishes a two-way data communication link with the hospital's LIS system, receives preset custom specimen screening conditions from operators, automatically retrieves, verifies, and stores patient basic information, specimen testing data, and specimen unique identifiers that match the conditions, generates a standardized target specimen processing list, and simultaneously distributes it to other operation modules.

[0032] The LIS data linkage and interaction module internally includes a visual condition configuration unit, a real-time data retrieval unit, a data verification unit, and a data synchronization and storage unit.

[0033] The visual condition configuration unit allows operators to enter, modify, save, and recall single or combined screening conditions online. Screening conditions include any combination of upper and lower limits of test item values, interval thresholds, and disease types.

[0034] The real-time data retrieval unit connects to the LIS database in real time according to preset conditions, and batch retrieves data related to medical record number, patient name, test items, test results, original specimen number, sampling time, and instrument testing time.

[0035] The data verification unit performs duplicate data removal, missing field completion, and abnormal value screening on the captured batch data, filtering invalid data to ensure that the target specimen list data is unique and accurate;

[0036] The data synchronization storage unit persistently stores the filtering conditions, the original retrieved data, and the verified and cleaned list data in real time, supporting data backtracking and secondary retrieval later.

[0037] The intelligent specimen positioning and picking module communicates with the LIS data linkage and interaction module, receiving the target specimen processing list and using barcode recognition and coordinate calibration technology to accurately sort, pick up, and transport disordered specimens. The intelligent specimen positioning and picking module has built-in specimen barcode recognition unit, position calibration unit, flexible mechanical sorting unit, and anomaly warning unit.

[0038] The specimen barcode recognition unit scans the original barcode of each specimen to be processed and compares and matches it with the specimen number in the list in real time.

[0039] The position calibration unit collects the coordinates of all specimens in the specimen tray in real time and dynamically corrects the sorting position of the robotic arm to adapt to the scenario of disordered specimen stacking.

[0040] The flexible mechanical sorting unit uses a silicone flexible clamping structure to grip the specimen tube wall, avoiding damage to the tube wall and hemolysis caused by violent shaking of the specimen due to rigid clamping;

[0041] When the abnormality warning unit identifies specimen matching failure, missing target specimen, or robotic arm sorting jam, it automatically triggers an audible and visual alarm and records the fault location and fault time to the abnormality log.

[0042] The automated specimen dispensing and packaging module connects to the output station of the intelligent specimen positioning and picking module, receives the sorted target blood specimens, and automatically completes the entire standardized dispensing process, including centrifugation, quantitative pipetting, and cryotube capping.

[0043] The automated specimen dispensing and packaging module includes a centrifugation separation unit, an adaptive pipetting unit, a tube cap delivery unit, and a sealing unit;

[0044] The centrifugation unit automatically performs stable centrifugation separation of serum or plasma by pre-setting specific centrifugation speed and centrifugation time parameters according to the type of blood sample.

[0045] The adaptive pipetting unit incorporates a viscosity detection sensor and flow compensation algorithm to dynamically adjust the pipetting negative pressure and extraction flow rate based on the sample viscosity in real time. The pipetting accuracy is stably controlled within ±0.05ml, accurately and quantitatively aspirating a preset volume of serum / plasma into sterile cryovials, eliminating problems such as viscous sample adhesion to the wall and extraction volume deviation.

[0046] The tube cap delivery unit enables orderly and automatic feeding and positioning of frozen tube caps, with continuous supply of tube caps without manual intervention; the cap sealing unit adaptively adjusts the pressing pressure according to the diameter of the frozen tube to complete the sealing and locking of the tube cap, preventing sample low-temperature leakage and external contamination.

[0047] The intelligent labeling and printing module is connected to the LIS data linkage and interaction module and the automated specimen dispensing and packaging module. It retrieves the corresponding patient information and test data, generates a unique specimen serial number, and automatically prints a low-temperature special label and affixes it to the outer wall of the cryotube. The module includes a label template editing unit, a low-temperature weather-resistant printing unit, and an adaptive labeling unit.

[0048] The label template editing unit allows operators to customize the label display content. The labels are forcibly fixed to include the patient's unique number, specimen type, target test item, test value, specimen processing time, unique specimen serial number and other core traceability information.

[0049] The low-temperature weather-resistant printing unit uses medical low-temperature resistant PP label substrate with long-lasting resin ribbon, which is suitable for long-term storage at ultra-low temperature of -80℃. The text will not fade or the barcode will become invalid after long-term storage. The adaptive labeling unit can automatically adjust the labeling angle, bonding pressure and label pasting position according to different specifications of cryogenic tube diameter, ensuring that the label is flat and wrinkle-free with no curling edges.

[0050] The specimen archiving and management module communicates with the intelligent labeling and printing module to scan and identify the labeled cryogenic tubes, automatically completing specimen information archiving, full-process log retention, and ultra-low temperature storage ledger management; the module includes a barcode scanning and identification unit, a log storage unit, a traceability query unit, and a storage adaptation management unit;

[0051] The barcode scanning and recognition unit is compatible with both barcode and QR code bidirectional recognition, quickly reads all specimen information in the label and uploads it to the laboratory specimen management system simultaneously;

[0052] The log storage unit records the entire process of specimen screening, sorting, centrifugation, pipetting, capping, printing and labeling, and archiving, including operation data, time points, and equipment operating parameters, with the logs permanently stored in an tamper-proof encrypted format.

[0053] The traceability query unit allows operators to input any keywords such as specimen serial number, medical record number, test item, and specimen processing time to retrieve the entire process record of the specimen with one click, achieving complete traceability.

[0054] The storage adaptation management unit matches the storage specifications of the -80℃ ultra-low temperature freezer, automatically classifies and numbers archived specimens, records the shelf and compartment of each specimen stored in the freezer, and automatically generates an electronic storage ledger.

[0055] The device features a multi-device compatible interface with a standardized universal data interface, enabling it to connect to mainstream hospital LIS systems and third-party laboratory specimen management systems. The hardware supports stand-alone small-batch operation mode and continuous large-scale batch operation mode, and can perform parallel calculations of multiple sets of different composite screening conditions to process multiple types of target specimens simultaneously.

[0056] like Figure 2 As shown:

[0057] This invention provides an automated post-processing method for test specimens based on LIS data linkage, applied to the aforementioned system, comprising the following steps:

[0058] S1. Conditional Start-up: Operators input and save single / composite specimen screening conditions through the visual interface of the LIS data linkage interaction module, and issue a whole machine start-up command after confirmation.

[0059] S2, LIS data linkage screening: The LIS data linkage interaction module establishes real-time communication with the hospital's LIS system, batch captures and matches patient and specimen association data, removes duplicate, missing and abnormal data through the data verification unit, generates a standardized target specimen processing list and simultaneously distributes it to each operation module;

[0060] S3. Intelligent specimen sorting: The intelligent specimen positioning and picking module automatically identifies and flexibly picks up target blood specimens in the list through barcode scanning and dynamic coordinate calibration, and transports them to the dispensing station in an orderly manner.

[0061] S4. Standardized dispensing and packaging: The automated specimen dispensing and packaging module automatically centrifuges the target specimen to separate serum / plasma, and the adaptive pipetting unit quantitatively aspirates a predetermined volume of sample with an accuracy of ±0.05ml and transfers it to the cryovial. After the tube cap is automatically loaded, the adaptive pressure cap is sealed.

[0062] S5. Automatic printing and labeling: The intelligent labeling and printing module retrieves the specimen association information, generates a unique specimen serial number, prints standardized labels using low-temperature weather-resistant consumables, and the adaptive labeling mechanism flattens and adheres the labels to the outer wall of the cryotube.

[0063] S6. Scan-to-Archive Storage: The specimen archiving management module scans the cryovial label, automatically synchronizes the specimen information to the specimen management system, and generates an unalterable full-process processing log. Operators place the archived specimens in an -80℃ ultra-low temperature freezer for long-term storage according to the system classification number, and can subsequently retrieve and trace the source from multiple dimensions.

[0064] The data verification operation in step S2 specifically includes duplicate data removal, missing field completion, and abnormal value screening; the pipetting accuracy of step S4 quantitative sample aspiration is stably controlled within ±0.05ml.

[0065] Example 1;

[0066] This embodiment uses the screening of blood samples from patients with type 2 diabetes whose fasting blood glucose level is >10 mmol / L and the completion of long-term storage at -80℃ as the application scenario. The entire automated process of this system is fully executed, and the specific steps are as follows:

[0067] S1. Visual configuration of screening conditions: Operators can create composite screening conditions through the visual operation interface of the LIS data linkage and interaction module: select type 2 diabetes as the disease type, set the lower limit of the fasting blood glucose threshold to 10 mmol / L for the test item, save the conditions and issue the whole machine start command.

[0068] S2, Automatic Retrieval and Verification of LIS Data: The LIS data linkage and interaction module establishes an encrypted communication link to connect with the hospital's LIS system database, and batch retrieves the medical record number, patient name, fasting blood glucose test value, original specimen barcode, sampling time, and test completion time of all eligible specimens in the past 24 hours; the data verification unit automatically removes multiple data entries from the same patient that are retrieved repeatedly, invalid specimens with missing test results, and abnormal data that exceed the normal instrument testing range. After cleaning, a standardized target specimen processing list is generated and simultaneously sent to the intelligent specimen positioning and selection module;

[0069] S3. Intelligent Unordered Specimen Automatic Sorting: Specimens to be processed are placed disorderly on the equipment's feeding tray. The intelligent specimen positioning and picking module initiates full-area barcode scanning, reading the original barcode of each specimen and comparing it with the list in real time. The high-precision position calibration unit collects the coordinates of each specimen in the tray in real time, dynamically correcting the robotic arm's gripping position. The flexible mechanical clamping mechanism accurately grasps the successfully matched diabetic target specimens and transports them orderly to the dispensing station. Unmatched specimens are automatically retained on the feeding tray, and the equipment continues sorting without manual intervention. If a target specimen is missing or the barcode cannot be recognized, the equipment automatically sounds and lights an alarm and records the abnormality log.

[0070] S4. Standardized Centrifugation, Quantitative Pipetting, and Adaptive Capping: After the target specimen is delivered to the dispensing station, the centrifugation unit automatically centrifuges the blood specimen using preset centrifugation parameters (3000 r / min, 10 min) to stably separate the upper serum layer; the adaptive precision pipetting unit uses a built-in sensor to detect serum viscosity in real time, automatically adjusts the negative pressure for extraction, and precisely and quantitatively aspirates 2 ml of serum sample, transferring it to sterile cryovials without any residue adhering to the tube walls; the tube cap delivery unit automatically delivers the matching cryovial caps to the capping station, and the capping unit adjusts the pressing pressure according to the cryovial diameter to complete the sealing and locking, preventing low-temperature leakage and contamination;

[0071] S5. Low-temperature label automatic printing and precise application: After the sub-packaging is completed, the intelligent labeling and printing module retrieves all patient information, fasting blood glucose test values, and automatically generates a unique specimen serial number. It then retrieves a preset label template to generate an electronic label. The printing is completed using low-temperature resistant PP labels and long-lasting carbon ribbons. The adaptive labeling mechanism automatically adjusts the labeling angle and pressure to flatly apply the label to the outer wall of the middle part of the cryotube, without wrinkles or curling edges.

[0072] S6, code scanning archiving, low-temperature storage and traceability retention: the labeled cryotubes are transported to the archiving station, the code scanning identification unit automatically scans the two-dimensional code on the label to read all specimen information, and uploads it synchronously to the specimen management system of the clinical laboratory; the log storage unit encrypts and records the current specimen screening time, sorting time, centrifugation parameters, pipetting volume, labeling time and archiving time, and the log cannot be tampered with permanently; the operator places the specimens in the designated compartment of a -80°C ultra-low temperature refrigerator according to the classification number generated by the system's storage adaptation management unit, and the system automatically registers the storage position; if the specimens need to be retrieved for scientific research subsequently, the full-process processing records of the specimens can be queried with one click by inputting the medical record number or the unique serial number of the specimens, realizing complete traceability.

[0073] Example 2, implementation verification of high-precision quantification performance of adaptive pipetting unit;

[0074] This example performs batch performance test on the adaptive pipetting unit in the automatic specimen subpackaging and encapsulation module:

[0075] 500 low-viscosity serum samples and 500 high-viscosity hyperlipidemia plasma samples were selected respectively, and the adaptive pipetting unit of the system was used to quantitatively extract 2ml of samples and transfer them to cryotubes; the viscosity detection sensor built in the equipment identifies the viscosity of the samples in real time, and calls the flow compensation algorithm to dynamically adjust the pipetting extraction flow rate and negative pressure;

[0076] Batch test results show that the extraction volume error of all 1000 samples is controlled within ±0.05ml, there is no sample wall hanging, insufficient extraction or excessive extraction, and the qualification rate of quantitative extraction is 100%; compared with the traditional semi-automatic pipetting equipment with fixed parameters, the maximum extraction volume deviation of high-viscosity plasma can reach 0.3ml. The adaptive adjustment mechanism of the present invention greatly improves the degree of sample quantification standardization, and fully meets the unified retention accuracy requirements for medical scientific research samples.

[0077] Example 3, implementation of adaptation for long-term storage of low-temperature weather-resistant labels:

[0078] This example carries out durability test on the low-temperature labels matched with the intelligent labeling and printing module: the cryotubes with printed labels are placed in a -80°C ultra-low temperature refrigerator for continuous storage for 36 months, and the labels are taken out regularly for scanning to detect the label status. The test results show that the label base material has no cracking, no edge warping and falling off, the printed characters by the ribbon are clear and complete, and the recognition rate of the two-dimensional code and bar code built in the label is 100% throughout the process; compared with ordinary paper laminated labels, which have problems of blurred characters, unscannable bar codes and label falling off and failure after 3 months of storage. The special low-temperature label of the present invention adapts to the ultra-low temperature long-term storage scenario, and solves the pain points of label failure and untraceability after long-term retention of specimens.

[0079] Example 4, implementation of multi-scenario compatible operation mode:

[0080] This invention features two switchable operating modes to adapt to medical institutions of different sizes:

[0081] Standalone operation mode: Suitable for secondary hospitals and small specialized laboratories. The equipment is placed separately and can process 50-200 samples at a time, completing the entire post-processing process independently without the need for a supporting production line.

[0082] Streamline batch processing mode: Suitable for top-tier general hospitals and large medical research sample banks. The equipment connects to the laboratory specimen processing line through a multi-device compatible interface, receiving continuously processed specimens from the line and processing them automatically without interruption. It can simultaneously run three sets of different composite screening conditions, classifying and storing specimens from multiple diseases concurrently. Furthermore, the system's standardized data interface can directly connect to mainstream LIS systems on the market (such as Kingdee, Neusoft, and Sinosen Laboratory Systems), achieving data interoperability without custom development. The equipment is highly versatile and has low deployment and adaptation costs.

[0083] This solution establishes a data interaction link with the hospital's LIS system, supports multi-dimensional composite screening conditions, and is equipped with multiple data verification mechanisms to automatically clean abnormal and duplicate data, generating an accurate list of target specimens. This eliminates the problems of missed or incorrect selection caused by manual retrieval and handwritten numbering from the source. The specimen screening, sorting, packaging, labeling, and archiving are all automated in a closed loop, eliminating the need for manual intervention in core processes. This significantly improves batch processing efficiency and reduces the manpower input and human operation risks in the laboratory.

[0084] Equipped with an adaptive pipetting unit featuring a viscosity compensation algorithm, the pipetting accuracy is controlled within ±0.05ml. Combined with standardized centrifugation and an adaptive pressure cap structure, it unifies the volume and sealing standards of all retained samples, effectively avoiding problems such as volume deviation from manual pipetting, hemolysis of specimens, and sample leakage and contamination, ensuring the uniformity of scientific research retained samples and the stability of long-term storage.

[0085] The equipment is equipped with a low-temperature weather-resistant printing component, which automatically generates standardized traceability labels with unique serial numbers. It is suitable for long-term storage at ultra-low temperatures of -80℃, and the labels do not fade, fall off, or become invalid. The adaptive labeling mechanism ensures that the labels are flat and adhered, completely solving the pain points of traditional paper labels failing at low temperatures and mismatch between specimens and information.

[0086] The system retains an unalterable electronic operation log throughout the entire process, supports one-click traceability of multiple dimensions such as medical record number, specimen number, and test items, and automatically generates storage ledgers for ultra-low temperature freezers, fully meeting the compliance traceability supervision requirements of biobanks and hospital laboratories.

[0087] The system is equipped with a universal and compatible interface that can connect to mainstream LIS and specimen management systems. It also supports two operating modes: single-machine small-batch and pipeline-scale operation, making it suitable for different usage scenarios in hospitals at all levels and research sample banks. The equipment has stronger versatility and expandability.

[0088] It should be noted that: This system is equipped with a real-time fault monitoring unit at every workstation. If abnormal conditions occur, such as LIS data communication interruption, specimen sorting stagnation, pipetting pump failure, capping jam, or label printing paper shortage, the equipment will immediately activate an audible and visual alarm and accurately record the faulty workstation, the time of occurrence, and the type of fault in an encrypted anomaly log. This facilitates rapid repair by staff and ensures continuous and stable operation of the equipment. All specimen data, operation logs, and screening conditions are encrypted and stored, supporting both local storage and cloud backup. The data cannot be deleted or tampered with, fully complying with medical data security management standards.

[0089] Finally, it should be noted that the above descriptions are merely preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. An automated post-processing system for laboratory specimens based on LIS data linkage, comprising a specimen post-processing equipment body for sorting, packaging, labeling, and archiving laboratory specimens, characterized in that, Also includes: The LIS data linkage and interaction module is configured to establish a data communication link with the hospital's LIS system, respond to the custom specimen screening conditions preset by the staff, retrieve, verify and store patient information and specimen information that meet the screening conditions from the LIS system, and generate a target specimen processing list. The intelligent specimen positioning and picking module is connected to the LIS data linkage and interaction module, receives the target specimen processing list, locates and verifies the target blood specimens after completion by barcode comparison, and performs the sorting, picking and transportation of the target specimens. An automated specimen dispensing and packaging module is connected to the specimen output station of the intelligent specimen positioning and picking module. It is used to perform centrifugation on the target blood specimen delivered to the station to obtain serum or plasma samples, quantitatively aspirate a predetermined volume of serum or plasma samples and transfer them to cryovials, and perform capping operations on the cryovials. The intelligent labeling and printing module is connected to the LIS data linkage and interaction module and the automated specimen dispensing and packaging module respectively. It is used to obtain the patient information and test data of the corresponding specimen and generate a unique specimen serial number, perform label printing and attach the printed label to the outer wall of the cryotube. as well as The specimen archiving management module is communicatively connected to the intelligent labeling and printing module. It is used to scan the labels on the cryovials to complete the specimen information entry and archiving storage, and generate a full-process processing log.

2. The automated post-processing system for test specimens based on LIS data linkage according to claim 1, characterized in that: The LIS data linkage and interaction module includes: The visual condition configuration unit is used for staff to input, modify, save and call the custom specimen screening conditions, which include at least one of the upper limit, lower limit and interval threshold of the detection item value; The real-time data retrieval unit is used to connect to the LIS system database in real time according to the custom specimen screening conditions, so as to retrieve the matching patient medical record number, name, test items, test results, specimen number, sampling time and test time; The data verification unit is used to perform duplicate data removal, missing data completion, and abnormal data screening on the data captured by the real-time data retrieval unit; and The data synchronization storage unit is used to synchronously store the custom specimen screening conditions, the captured data, and the verification results.

3. The automated post-processing system for test specimens based on LIS data linkage according to claim 1, characterized in that: The intelligent specimen positioning and picking module includes: The specimen barcode recognition unit is used to scan and recognize the original barcodes of batch specimens and compare them with the target specimen processing list; The position calibration unit is used to collect specimen placement information and dynamically calibrate the sorting operation position; Flexible mechanical sorting units are used to grasp target specimens using a flexible gripping method; and The anomaly warning unit is used to trigger warnings and record anomaly logs when specimen matching fails, specimens are missing, or sorting is stuck.

4. The automated post-processing system for test specimens based on LIS data linkage according to claim 1, characterized in that: The automated specimen dispensing and packaging module includes: The centrifugation unit is used to perform centrifugation separation according to the type of blood sample using preset centrifugation parameters; An adaptive pipetting unit is used to quantitatively aspirate serum or plasma samples and transfer them to cryovials; The tube cap conveying unit is used to automatically feed refrigerated tube caps to the capping station; and A capping unit is used to press and seal the freezer tube cap onto the freezer tube.

5. The automated post-processing system for test specimens based on LIS data linkage according to claim 4, characterized in that: The adaptive pipetting unit incorporates a viscosity detection sensor and a flow compensation algorithm to adjust pipetting parameters according to the sample viscosity. The pipetting accuracy of the adaptive pipetting unit is ±0.05 ml.

6. The automated post-processing system for test specimens based on LIS data linkage according to claim 1, characterized in that: The intelligent label printing module includes: The label template editing unit is used for staff to customize label content templates. The labels include the patient's unique number, specimen type, test items, test values, specimen processing time, and unique specimen serial number. The low-temperature weather-resistant printing unit uses low-temperature resistant label media and long-lasting ribbons for label printing; and An adaptive labeling unit is used to adjust the labeling angle, labeling pressure, and labeling position according to the diameter of the refrigeration tube.

7. The automated post-processing system for test specimens based on LIS data linkage according to claim 1, characterized in that: The specimen archiving management module includes: The scanning and recognition unit supports QR code recognition and / or barcode recognition, and is used to read the specimen information on the cryotube label and synchronize it to the specimen management system; The log storage unit is used to record and store the operation data and time nodes of the entire process of specimen screening, sorting, packaging, sealing, labeling and archiving. The log is in an immutable format. The traceability query unit supports traceability queries by specimen serial number, medical record number, testing item, or processing time; and The storage adaptation management unit is used to classify and number archived specimens according to the ultra-low temperature freezer storage specifications and register their storage locations.

8. The automated post-processing system for test specimens based on LIS data linkage according to claim 1, characterized in that: The system also includes a multi-device compatible interface, which is used to interface with the hospital LIS system and / or the laboratory specimen management system. The system supports stand-alone operation mode and automated batch operation mode.

9. An automated post-processing method for laboratory specimens based on LIS data linkage, characterized in that, The method, applied to the automated post-processing system for test specimens according to any one of claims 1 to 8, comprises the following steps: S1. Input and save the custom specimen screening conditions through the LIS data linkage interaction module, and issue a system start command after confirmation. S2. The LIS data linkage and interaction module retrieves matching patient data and specimen data from the hospital's LIS system, and generates a target specimen processing list after data verification. S3. The intelligent specimen positioning and picking module identifies the target blood specimen by barcode comparison according to the target specimen processing list, and performs sorting, picking and transporting to the packaging station. S4. The automated specimen dispensing and packaging module centrifuges the target blood specimen to obtain serum or plasma samples, quantitatively aspirates a predetermined volume of sample and transfers it to a cryotube, and seals the cryotube. S5. The intelligent labeling and printing module acquires the patient information and test data of the corresponding specimen and generates a unique specimen serial number, performs label printing, and affixes the label to the outer wall of the cryotube. S6. The specimen archiving management module scans the label to automatically archive the specimen information and generate a processing log.

10. The automated post-processing method for test specimens based on LIS data linkage according to claim 9, characterized in that: The data verification in S2 includes: The retrieved data is subjected to duplicate data removal, missing data completion, and abnormal data screening; in S4, the pipetting accuracy of the quantitative aspiration is ±0.05ml.

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