Composite iodine preparation containing quaternary ammonium salt cationic surfactant and preparation method thereof

Abstract

The application discloses a composite iodine preparation containing a quaternary ammonium salt cationic surfactant and a preparation method thereof, and belongs to the technical field of disinfectant liquids; the preparation method comprises the following steps: dissolving sodium sulfite in purified water to obtain a sodium sulfite solution; taking part of the sodium sulfite solution, adding a non-ionic surfactant and a quaternary ammonium salt cationic surfactant under nitrogen protection, stirring and dissolving, and heating to obtain solution A; taking part of the sodium sulfite solution, sequentially adding a stabilizer, iodine and an auxiliary agent, stirring and dissolving to obtain solution B; mixing solution B with solution A, and adding the remaining sodium sulfite solution to be stirred and mixed; and after cooling, the pH value is adjusted to 4.5-5.5 to prepare the composite iodine preparation. The composite iodine preparation has the characteristics of good bactericidal efficiency, fast speed, multiple bactericidal types and remarkable synergistic effect, and has good stability.

Description

Technical Field

[0001] This invention belongs to the field of disinfectant technology, specifically relating to a composite iodine preparation containing quaternary ammonium salt cationic surfactants and its preparation method. Background Technology

[0002] Disinfectants are widely used in modern life, especially in medical institutions where they are frequently used to control bacterial infections. They primarily work by disrupting the structure of pathogens or inhibiting their activity, thereby killing or eliminating bacteria, viruses, and other microorganisms to block transmission routes and prevent the spread of infection. Currently, there are many types of disinfectants with varying disinfection effects. An ideal disinfectant should possess characteristics such as a broad bactericidal spectrum, rapid disinfection, stable performance, and low toxicity. Iodine, as a highly effective bactericidal and disinfectant, possesses broad-spectrum antibacterial properties and low drug resistance, and has been widely used in clinical, hygiene, daily life, agriculture and animal husbandry, and drinking water fields. With technological advancements, numerous iodine-containing bactericidal disinfectants have emerged, such as iodine tincture and povidone-iodine. Iodine tincture, also known as iodine solution, is an alcoholic solution of iodine and potassium iodide. It has broad-spectrum, high-efficiency, and rapid disinfection characteristics, and can quickly kill a variety of pathogens, including bacteria, fungi, and viruses. Its powerful disinfection ability is mainly due to the synergistic effect of its high concentration of iodine and alcohol. However, iodine tincture also has obvious disadvantages. It is highly irritating and corrosive, and can easily damage the skin and mucous membranes. After use, it needs to be deiodized with alcohol to avoid continuous damage to the skin. It cannot be used for large-area disinfection or mucous membrane disinfection, which limits its application scope. Povidone-iodine solution, also known as iodine tincture, is an amorphous iodine complex (PVP-I) of iodine and polyvinylpyrrolidone surfactant. It has broad-spectrum antimicrobial activity. Compared with iodine tincture, it overcomes the shortcomings of iodine tincture, such as high concentration, strong irritation, burn effect on the skin, instability and volatility, easy staining yellow, and narrow range of application. At the same time, it retains the broad-spectrum bactericidal properties and has a killing effect on a variety of bacteria, viruses and fungi. It is often used for sterilization and disinfection of external wounds, and can play a role in preventing infection and protecting the wound.

[0003] However, the stability of povidone-iodine still has certain issues. Factors such as pH, temperature, light, and concentration can significantly affect its effective iodine content. The main reasons are that alkaline environments easily exacerbate the oxidation reaction of iodine molecules, light exposure facilitates free radical reactions leading to degradation, and increased temperature accelerates iodine volatilization and oxidation. Low-concentration povidone-iodine solutions have a higher proportion of free iodine molecules and higher vapor pressure, resulting in vigorous volatilization and increased effective iodine loss. Therefore, improving the povidone-iodine production process and optimizing its formulation are crucial. In particular, carefully selecting the types and amounts of stabilizers is essential for extending product shelf life, improving product quality, and enhancing the safety and stability of povidone-iodine applications. Summary of the Invention

[0004] To address the shortcomings of existing technologies, the present invention aims to provide a composite iodine preparation containing quaternary ammonium salt cationic surfactants and its preparation method, thereby solving the problems in the prior art.

[0005] The objective of this invention can be achieved through the following technical solutions: A method for preparing a composite iodine preparation containing quaternary ammonium salt cationic surfactants includes the following steps: Sodium sulfite was dissolved in purified water to obtain a sodium sulfite solution; Take a portion of sodium sulfite solution, add a nonionic surfactant and a quaternary ammonium salt cationic surfactant under nitrogen protection, stir to dissolve and heat to obtain solution A; Take a portion of sodium sulfite solution, add stabilizer, iodine and auxiliary agent in sequence, stir to dissolve, and obtain solution B; Mix solution B with solution A, and add the remaining sodium sulfite solution and stir to mix; after cooling, adjust the pH to 4.5~5.5 to obtain the compound iodine preparation.

[0006] Furthermore, the molar concentration of the sodium sulfite solution is 0.025 mol / L.

[0007] Furthermore, the nonionic surfactant is any two of the following: fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, polyvinylpyrrolidone, and Tween 20, combined in a 1:1 mass ratio.

[0008] Furthermore, the quaternary ammonium salt cationic surfactant is a mixture of dodecyl dimethyl ethylphenoxyethyl ammonium bromide and bis(dodecyl dimethyl) ammonium bromide in a mass ratio of 1:2.

[0009] Furthermore, the stabilizer is a mixture formed by butyl acetate and one of sodium citrate, sodium potassium tartrate, and sodium salicylate; and the mass percentage of butyl acetate in the stabilizer is 2 / 3.

[0010] Furthermore, the auxiliary agent is potassium iodide and potassium iodate.

[0011] Furthermore, in the compound iodine preparation, the mass percentage of nonionic surfactant is 3-10%, the mass percentage of quaternary ammonium salt cationic surfactant is 2-5%, the mass percentage of stabilizer is 1-5%, the mass percentage of iodine is 0.1-1%, the mass percentage of potassium iodide is 0.1-0.5%, and the mass percentage of potassium iodate is 0.1-0.5%.

[0012] Furthermore, the pH is adjusted using a pH adjuster, which is a mixture of glycine and one of citric acid, phosphoric acid, or hydrochloric acid; and the mass percentage of glycine in the pH adjuster is 1 / 3.

[0013] The composite iodine preparation containing quaternary ammonium salt cationic surfactants was prepared using the method described above.

[0014] The above-mentioned compound iodine preparations containing quaternary ammonium salt cationic surfactants are used in sterilization and disinfection.

[0015] The beneficial effects of this invention are: 1. The composite iodine preparation containing quaternary ammonium salt cationic surfactants prepared in this invention has the characteristics of broad bactericidal spectrum, fast speed and low toxicity. Its kill rate against Staphylococcus aureus and Candida albicans is higher than 99.5% within 5 minutes. Moreover, it has better stability than other similar iodine preparations. The effective iodine content only decreases by 1.9-2.8% after 30 days, without precipitation or stratification. This is attributed to the synergistic effect between quaternary ammonium salt cationic surfactants and glycine with iodine preparations, as well as the higher solubility of iodine in butyl acetate. It can be widely used in clinical, health and daily life fields.

[0016] 2. Polyvinylpyrrolidone (PVP-I): PVP-I is a complex of polyvinylpyrrolidone and iodine (povidone-iodine). Iodine is transported in the form of complexes or ligands at the micelle centers formed by the surfactant, exhibiting very high solubilization efficiency for iodine, effectively reducing the vapor pressure of iodine, and providing stable solubilization over a wide pH range. Povidone-iodine gradually depolymerizes and dissolves in aqueous media, releasing free iodine atoms to achieve a bactericidal effect. Simultaneously, due to the hydrophilicity of polyvinylpyrrolidone, it facilitates mass transfer between cell membranes and cytoplasm, resulting in a long-lasting, mild, and low-irritant bactericidal effect. It is widely used in hospital disinfection both domestically and internationally.

[0017] 3. The quaternary ammonium salt cationic surfactant of the present invention is itself an effective antibacterial agent, mainly including two categories: single-chain quaternary salts and double-chain quaternary ammonium salts. The former is represented by dodecyl dimethyl ethylphenoxyethyl ammonium bromide (Domiphen), and the latter is represented by didodecyl dimethyl ammonium bromide (Baidusha). Iodine tincture prepared with quaternary ammonium salt cationic surfactants is stable, has low toxicity, low irritation, low corrosiveness, and good micelle formation. In addition to antistatic effect, it also has a synergistic effect. Even in the presence of organic matter, under moderately alkaline conditions, and even after iodine loses its activity, the surfactant still has bactericidal activity.

[0018] 4. The stabilizer (butyl acetate, sodium citrate, potassium sodium tartrate or sodium salicylate), auxiliary agent (potassium iodide and potassium iodate), and pH adjuster (glycine, citric acid, phosphoric acid or hydrochloric acid, pH=4.5-5.5) of the present invention, along with nonionic and quaternary ammonium salt cationic surfactants under nitrogen protection, can be combined with refined iodine to obtain a more efficient, broad-spectrum and stable iodine disinfectant with a wide range of applications. Detailed Implementation

[0019] The technical solution of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0020] A method for preparing a composite iodine preparation containing a quaternary ammonium salt cationic surfactant includes the following steps: S1. Add sodium sulfite solid to purified water and stir until completely dissolved to remove dissolved oxygen in the water, thus preparing a sodium sulfite solution with a molar concentration of 0.025 mol / L. S2, take 1 / 4 volume of the sodium sulfite solution obtained from S1, add a nonionic surfactant and a quaternary ammonium salt cationic surfactant under nitrogen protection, stir to dissolve and heat to 35~45℃, let stand for 15~20 min to form solution A; S3: Take 1 / 4 volume of the sodium sulfite solution obtained from S1, add stabilizer, iodine and auxiliary agent in sequence, stir to dissolve, and let stand for 5-10 min to form solution B; S4. Mix solution B with solution A, add the remaining sodium sulfite solution, keep warm at 35-45℃, and stir continuously for 15-25 minutes at a stirring speed of 15-20 rpm. Finally, cool to room temperature, add a pH adjuster, and stir continuously until the solution pH is between 4.5 and 5.5 to obtain a composite iodine preparation containing a quaternary ammonium salt cationic surfactant.

[0021] In S2, the nonionic surfactant is any two of the following: fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, polyvinylpyrrolidone, and Tween 20, combined in a 1:1 mass ratio.

[0022] In S2, the quaternary ammonium salt cationic surfactant is a mixture of dodecyl dimethyl ethylphenoxyethyl ammonium bromide and bis(dodecyl dimethyl) ammonium bromide in a mass ratio of 1:2.

[0023] In S3, the stabilizer is a mixture of butyl acetate and one of sodium citrate, sodium potassium tartrate, and sodium salicylate; and the mass percentage of butyl acetate in the stabilizer is 2 / 3.

[0024] In S3, the additives are potassium iodide and potassium iodate.

[0025] In S4, the pH adjuster is a mixture of glycine and one of citric acid, phosphoric acid, or hydrochloric acid; and the mass percentage of glycine in the pH adjuster is 1 / 3.

[0026] In compound iodine preparations, the mass percentage of nonionic surfactants is 3-10%, the mass percentage of quaternary ammonium salt cationic surfactants is 2-5%, the mass percentage of stabilizers is 1-5%, the mass percentage of iodine is 0.1-1%, the mass percentage of potassium iodide is 0.1-0.5%, and the mass percentage of potassium iodate is 0.1-0.5%.

[0027] The technical solution of the present invention will be described below through the following embodiments; the information of the relevant raw materials is as follows: Didodecyl dimethyl ammonium bromide: Net content 98.%, CAS: 3282-73-3; Shanghai Maclean Biochemical Technology Co., Ltd. Refined iodine: Net content 99.8%, analytical grade, CAS: 7553-56-2, Jinhai Iodine Chemical (Qingdao) Co., Ltd.; Glycine: Net content: 98.5%, food grade, CAS: 56-40-6, Jiangsu Yongke Bioengineering Co., Ltd.; Citric acid: Net content: 99.9%, industrial grade, CAS: 77-92-9, Shandong Yingxuan Industrial Co., Ltd.; Phosphoric acid: Net content: 85.0%, analytical grade, CAS: 7664-38-2, Sinopharm Chemical Reagent Co., Ltd.; Hydrochloric acid: Net content: 36.0-38.0%, analytical grade, CAS: 7647-01-0, Sinopharm Chemical Reagent Co., Ltd.

[0028] Example 1 Step I: Take an appropriate amount of purified water and add sodium sulfite solid to it to prepare a sodium sulfite solution with a molar concentration of 0.025 mol / L. Stir until completely dissolved to remove dissolved oxygen from the water. Set aside for later use. This solution is unstable and must be prepared on the same day.

[0029] Step II: Pour 1 / 4 volume of the sodium sulfite solution from Step I into a sealed reactor equipped with a stirrer and heating device, and purge the air from the upper part of the reactor with nitrogen to provide a nitrogen-protected environment. Then, add fatty alcohol polyoxyethylene ether and alkylphenol polyoxyethylene ether in a mass ratio of 1:1 (3.0% by mass), and dodecyl dimethyl ethylphenoxyethyl ammonium bromide and bisdodecyl dimethyl ammonium bromide in a mass ratio of 1:2 (5.0% by mass) sequentially into the reactor, stir until completely dissolved, heat to 35°C, and let stand for 20 min to form solution A; Step III: Take another 1 / 4 volume of the sodium sulfite solution from Step I into another sealed reaction vessel, and add an appropriate amount of a mixture of butyl acetate and sodium citrate in a mass ratio of 2:1 and a mass percentage of 1.0%, as well as 0.1% purified iodine, 0.1% potassium iodide and 0.1% potassium iodate in sequence and quickly add them to the mixture, stirring until completely dissolved. Let it stand for 5 minutes to form solution B. Step IV: Transfer all of solution B to solution A, and add the remaining sodium sulfite solution from step I. Maintain the temperature at 35°C and stir continuously for 15 minutes at a stirring speed of 20 rpm. Finally, turn on the cooling water to room temperature, and add a mixture of glycine and citric acid at a mass ratio of 1:2. Stir continuously until the pH of the solution reaches 4.5. Open the reaction vessel to obtain a composite iodine preparation containing a quaternary ammonium salt cationic surfactant.

[0030] Example 2 Step I: Take an appropriate amount of purified water and add sodium sulfite solid to it to prepare a sodium sulfite solution with a molar concentration of 0.025 mol / L. Stir until completely dissolved to remove dissolved oxygen from the water. Set aside for later use. This solution is unstable and must be prepared on the same day.

[0031] Step II: Pour 1 / 4 volume of the sodium sulfite solution from Step I into a sealed reactor equipped with a stirrer and heating device, and purge the air from the upper part of the reactor with nitrogen to provide a nitrogen-protected environment. Then, add fatty alcohol polyoxyethylene ether and polyvinylpyrrolidone in a mass ratio of 1:1 (10.0% by mass), and dodecyl dimethyl ethylphenoxyethyl ammonium bromide and bis(dodecyl dimethyl) ammonium bromide in a mass ratio of 1:2 (2.0% by mass) sequentially into the reactor, stir until completely dissolved, heat to 45°C, and let stand for 15 min to form solution A; Step III: Take another 1 / 4 volume of the sodium sulfite solution from Step I into another sealed reaction vessel, and add an appropriate amount of a mixture of butyl acetate and sodium potassium tartrate in a mass ratio of 2:1 and a mass percentage of 5.0%, as well as 1.0% refined iodine, 0.5% potassium iodide and 0.5% potassium iodate in sequence and quickly, and stir until completely dissolved. Let stand for 10 min to form solution B; Step IV: Transfer all of solution B to solution A, and add the remaining sodium sulfite solution from step I. Maintain the temperature at 45°C and stir continuously for 25 minutes at a stirring speed of 15 rpm. Finally, turn on the cooling water to room temperature, and add a mixture of glycine and phosphoric acid at a mass ratio of 1:2. Stir continuously until the solution pH reaches 5.5. Open the reaction vessel to obtain a composite iodine preparation containing a quaternary ammonium salt cationic surfactant.

[0032] Example 3 Step I: Take an appropriate amount of purified water and add sodium sulfite solid to it to prepare a sodium sulfite solution with a molar concentration of 0.025 mol / L. Stir until completely dissolved to remove dissolved oxygen from the water. Set aside for later use. This solution is unstable and must be prepared on the same day.

[0033] Step II: Pour 1 / 4 volume of the sodium sulfite solution from Step I into a sealed reactor equipped with a stirrer and heating device, and purge the air from the upper part of the reactor with nitrogen to provide a nitrogen-protected environment. Then, add fatty alcohol polyoxyethylene ether and Tween 20 in a mass ratio of 1:1 (5.0% by mass), and dodecyl dimethyl ethylphenoxyethyl ammonium bromide and bis(dodecyl dimethyl) ammonium bromide in a mass ratio of 1:2 (3.5% by mass) sequentially into the reactor, stir until completely dissolved, heat to 40°C, and let stand for 18 min to form solution A; Step III: Take another 1 / 4 volume of the sodium sulfite solution from Step I into another sealed reaction vessel, and add an appropriate amount of a mixture of butyl acetate and sodium salicylate in a mass ratio of 2:1 and a mass percentage of 3.0%, as well as 0.5% purified iodine, 0.3% potassium iodide and 0.3% potassium iodate in sequence and quickly add them to the mixture, stirring until completely dissolved. Let it stand for 8 minutes to form solution B. Step IV: Transfer all of solution B to solution A, and add the remaining sodium sulfite solution from step I. Maintain the temperature at 40°C and stir continuously for 20 minutes at a stirring speed of 18 rpm. Finally, turn on the cooling water to room temperature, and add a mixture of glycine and hydrochloric acid at a mass ratio of 1:2. Stir continuously until the pH of the solution reaches 5.0. Open the reaction vessel to obtain a composite iodine preparation containing a quaternary ammonium salt cationic surfactant.

[0034] Example 4 Step I: Take an appropriate amount of purified water and add sodium sulfite solid to it to prepare a sodium sulfite solution with a molar concentration of 0.025 mol / L. Stir until completely dissolved to remove dissolved oxygen from the water. Set aside for later use. This solution is unstable and must be prepared on the same day.

[0035] Step II: Pour 1 / 4 volume of the sodium sulfite solution from Step I into a sealed reactor equipped with a stirrer and heating device, and purge the air from the upper part of the reactor with nitrogen to provide a nitrogen-protected environment. Then, add alkylphenol polyoxyethylene ether and polyvinylpyrrolidone in a mass ratio of 1:1 (6.0% by mass), and dodecyl dimethyl ethylphenoxyethyl ammonium bromide and bis(dodecyl dimethyl) ammonium bromide in a mass ratio of 1:2 (3.0% by mass) sequentially into the reactor, stir until completely dissolved, heat to 45°C, and let stand for 20 min to form solution A; Step III: Take another 1 / 4 volume of the sodium sulfite solution from Step I into another sealed reaction vessel, and add an appropriate amount of a mixture of butyl acetate and sodium citrate in a mass ratio of 2:1 and a mass percentage of 5.0%, as well as 0.8% purified iodine, 0.6% potassium iodide and 0.6% potassium iodate in sequence and quickly, and stir until completely dissolved. Let stand for 10 min to form solution B; Step IV: Transfer all of solution B to solution A, and add the remaining sodium sulfite solution from step I. Maintain the temperature at 45°C and stir continuously for 20 minutes at a stirring speed of 20 rpm. Finally, turn on the cooling water to room temperature, and add a mixture of glycine and phosphoric acid at a mass ratio of 1:2. Stir continuously until the solution pH reaches 5.0. Open the reaction vessel to obtain a composite iodine preparation containing a quaternary ammonium salt cationic surfactant.

[0036] Example 5 Step I: Take an appropriate amount of purified water and add sodium sulfite solid to it to prepare a sodium sulfite solution with a molar concentration of 0.025 mol / L. Stir until completely dissolved to remove dissolved oxygen from the water. Set aside for later use. This solution is unstable and must be prepared on the same day.

[0037] Step II: Pour 1 / 4 volume of the sodium sulfite solution from Step I into a sealed reactor equipped with a stirrer and heating device, and purge the air from the upper part of the reactor with nitrogen to provide a nitrogen-protected environment. Then, add alkylphenol polyoxyethylene ether and Tween 20 in a mass ratio of 1:1 (3.0% by mass), and dodecyl dimethyl ethylphenoxyethyl ammonium bromide and bis(dodecyl dimethyl) ammonium bromide in a mass ratio of 1:2 (5.0% by mass) sequentially into the reactor, stir until completely dissolved, heat to 35°C, and let stand for 15 min to form solution A; Step III: Take another 1 / 4 volume of the sodium sulfite solution from Step I into another sealed reaction vessel, and add an appropriate amount of a mixture of butyl acetate and sodium potassium tartrate in a mass ratio of 2:1 and a mass percentage of 1.0, as well as 0.5% purified iodine, 0.2% potassium iodide and 0.3% potassium iodate in sequence and quickly add them to the mixture, stirring until completely dissolved. Let it stand for 5 minutes to form solution B. Step IV: Transfer all of solution B to solution A, and add the remaining sodium sulfite solution from step I. Maintain the temperature at 35°C and stir continuously for 15 minutes at a stirring speed of 15 rpm. Finally, turn on the cooling water to room temperature, and add a mixture of glycine and hydrochloric acid at a mass ratio of 1:2. Stir continuously until the solution pH reaches 5.5. Open the reaction vessel to obtain a composite iodine preparation containing a quaternary ammonium salt cationic surfactant.

[0038] Example 6 Step I: Take an appropriate amount of purified water and add sodium sulfite solid to it to prepare a sodium sulfite solution with a molar concentration of 0.025 mol / L. Stir until completely dissolved to remove dissolved oxygen from the water. Set aside for later use. This solution is unstable and must be prepared on the same day.

[0039] Step II: Pour 1 / 4 volume of the sodium sulfite solution from Step I into a sealed reactor equipped with a stirrer and heating device, and purge the air from the upper part of the reactor with nitrogen to provide a nitrogen-protected environment. Then, add polyvinylpyrrolidone and Tween 20 in a mass ratio of 1:1 (10.0% by mass), and dodecyl dimethyl ethylphenoxyethyl ammonium bromide and bis(dodecyl dimethyl) ammonium bromide in a mass ratio of 1:2 (2.0% by mass) sequentially into the reactor, stir until completely dissolved, heat to 40°C, and let stand for 15 min to form solution A; Step III: Take another 1 / 4 volume of the sodium sulfite solution from Step I into another sealed reaction vessel, and add an appropriate amount of a mixture of butyl acetate and sodium salicylate in a mass ratio of 2:1 and a mass percentage of 1.0%, as well as 0.4% purified iodine, 0.3% potassium iodide, and 0.3% potassium iodate in sequence and quickly add them to the mixture, stirring until completely dissolved. Let it stand for 10 minutes to form solution B. Step IV: Transfer all of solution B to solution A, and add the remaining sodium sulfite solution from step I. Maintain the temperature at 40°C and stir continuously for 25 minutes at a stirring speed of 18 rpm. Finally, turn on the cooling water to room temperature, and add a mixture of glycine and citric acid at a mass ratio of 1:2. Stir continuously until the solution pH reaches 4.5. Open the reaction vessel to obtain a composite iodine preparation containing a quaternary ammonium salt cationic surfactant.

[0040] Experimental Test The compound iodine preparations prepared in Examples 1-6 were tested experimentally as follows: 1. Experimental testing of the bactericidal effect of compound iodine preparation on vegetative bacteria and fungi; The experimental procedure included: setting up the compound iodine preparation groups (with effective iodine contents of 1.2, 10.8, 5.3, 8.3, 5.2, and 4.1 mg / L) prepared in Examples 1-6, as well as a sterile distilled water group (positive control) and a culture medium group (negative control). A bacterial suspension of 3.0 × 10⁸ cfu / mL was prepared. Referring to the bactericidal performance test method in the 2002 edition of the "Disinfection Technical Specifications," 5.0 mL of each group's test solution and 1.0 mL of bacterial suspension were added to sterile test tubes. After incubation for 1, 3, 5, and 9 minutes, 0.5 mL of the bacterial-drug mixture was taken out and 4.5 mL of neutralizing agent was added to each. After incubation for 10 minutes, 1.0 mL was poured into the corresponding culture medium and incubated at 37℃ for 48 hours. Viable bacteria were then counted. Each experiment was repeated three times, and the bactericidal rate was calculated. The experimental results are shown in Table 1. Table 1. Killing effect of compound iodine preparations on vegetative bacteria and fungi. 2. Experimental testing of the stability of the compound iodine preparation; The experimental procedure included: The compound iodine preparations obtained in Examples 1-6 were sealed in brown bottles (high-density polyethylene, HDPE) and stored at room temperature (around 25°C) in the dark for different numbers of days. For each day, 5 mL samples were taken and the effective iodine content was determined using the iodometric method (Hygienic requirements for iodine-containing disinfectants—Determination of effective iodine content GB / T 26368-2020). The experimental results are shown in Table 2. Table 2. Stability test results of compound iodine preparations In the description of this specification, references to terms such as "an embodiment," "example," "specific example," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the invention. In this specification, illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0041] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claimed invention.

Claims

1. A method for preparing a composite iodine preparation containing a quaternary ammonium salt cationic surfactant, characterized in that, Includes the following steps: Sodium sulfite was dissolved in purified water to obtain a sodium sulfite solution; Take a portion of sodium sulfite solution, add a nonionic surfactant and a quaternary ammonium salt cationic surfactant under nitrogen protection, stir to dissolve and heat to obtain solution A; Take a portion of sodium sulfite solution, add stabilizer, iodine and auxiliary agent in sequence, stir to dissolve, and obtain solution B; Mix solution B with solution A, and add the remaining sodium sulfite solution while stirring. After cooling, the pH was adjusted to 4.5-5.5 to obtain a compound iodine preparation.

2. The method for preparing the composite iodine preparation containing quaternary ammonium salt cationic surfactant according to claim 1, characterized in that, The molar concentration of the sodium sulfite solution is 0.025 mol / L.

3. The method for preparing the composite iodine preparation containing quaternary ammonium salt cationic surfactant according to claim 1, characterized in that, The nonionic surfactant is any two of the following: fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, polyvinylpyrrolidone, and Tween 20, combined in a 1:1 mass ratio.

4. The method for preparing the composite iodine preparation containing quaternary ammonium salt cationic surfactant according to claim 1, characterized in that, The quaternary ammonium salt cationic surfactant is a mixture of dodecyl dimethyl ethylphenoxyethyl ammonium bromide and bis(dodecyl dimethyl) ammonium bromide in a mass ratio of 1:

2.

5. The method for preparing a composite iodine preparation containing a quaternary ammonium salt cationic surfactant according to claim 1, characterized in that, The stabilizer is a mixture of butyl acetate and one of sodium citrate, sodium potassium tartrate, and sodium salicylate; and the mass percentage of butyl acetate in the stabilizer is 2 / 3.

6. The method for preparing a composite iodine preparation containing a quaternary ammonium salt cationic surfactant according to claim 1, characterized in that, The additives are potassium iodide and potassium iodate.

7. The method for preparing the composite iodine preparation containing quaternary ammonium salt cationic surfactant according to claim 6, characterized in that, In the compound iodine preparation, the mass percentage of nonionic surfactant is 3-10%, the mass percentage of quaternary ammonium salt cationic surfactant is 2-5%, the mass percentage of stabilizer is 1-5%, the mass percentage of iodine is 0.1-1%, the mass percentage of potassium iodide is 0.1-0.5%, and the mass percentage of potassium iodate is 0.1-0.5%.

8. The method for preparing the composite iodine preparation containing quaternary ammonium salt cationic surfactant according to claim 1, characterized in that, pH adjustment is achieved using a pH adjuster, which is a mixture of glycine and one of citric acid, phosphoric acid, or hydrochloric acid; and glycine accounts for 1 / 3 of the mass of the pH adjuster.

9. A compound iodine preparation containing quaternary ammonium salt cationic surfactants, characterized in that, It is prepared by the preparation method according to any one of claims 1-8.

10. The application of the composite iodine preparation containing quaternary ammonium salt cationic surfactant as described in claim 9 in sterilization and disinfection.

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