A fully automatic platelet aggregometer

Abstract

The present application relates to the technical field of platelet aggregation detection, in particular to a kind of full-automatic platelet aggregometer, including the lateral sliding connection of screw rod in aggregation detector, and mobile cross bar is provided with telescopic seat outside, the suction needle is vertically penetrated in the telescopic seat inside, the reagent rack for placing multiple different reagent bottles is arranged in the bottom of the aggregation detector inner cavity one side inside, the present application utilizes the drive motor in bottom support component, first one-way limiting elastic sheet, first one-way limiting elastic sheet, first one-way limiting tooth groove and second one-way limiting tooth groove, two kinds of rotation modes of sample test tube are realized, by forward rotation, drive entire test tube rack to rotate, can accurately move sample test tube to detection position, by reversing, only drive mixing gear rotation, drive sample test tube to rotate in situ and shake evenly, ensure that inducer and blood sample are quickly and uniformly mixed, while keeping test tube position stable, to reduce detection error.

Description

Technical Field

[0001] This invention relates to the field of platelet aggregation detection technology, and more specifically, to a fully automated platelet aggregation analyzer. Background Technology

[0002] Currently, in the field of clinical testing, the detection of platelet aggregation function is an important means of assessing the risk of thrombosis and bleeding. Traditional platelet aggregators mostly adopt semi-automatic or manual operation modes, requiring manual addition of inducing agents, manual shaking of samples, and individual testing. The operation process is cumbersome and time-consuming, with low detection efficiency and large errors.

[0003] In view of this, we propose a fully automated testing device that can quickly mix and accurately locate the components to solve the above-mentioned technical problems. Summary of the Invention

[0004] The purpose of this invention is to provide a fully automated platelet aggregator to solve the problems mentioned in the background art, such as the low detection efficiency and large error of traditional platelet aggregators that use manual operation mode.

[0005] To achieve the above objectives, the present invention provides a fully automated platelet aggregator, comprising an aggregator with a movable crossbar slidably connected laterally via a screw, and a telescopic seat disposed outside the movable crossbar. An aspiration needle is vertically inserted through the telescopic seat. A reagent rack for holding various reagent bottles is disposed on one side of the bottom of the aggregator's inner cavity, and a test tube insert for holding various sample tubes is disposed on the other side of the bottom of the aggregator's inner cavity. A cleaning cup is disposed between the reagent rack and the test tube insert, located inside the bottom of the aggregator's inner cavity. The test tube insert is positioned between the aggregator and the aggregator. The instrument is equipped with a detection groove located at the bottom of the inner cavity of the aggregation detector and on the outer side of the lower end of the upper plate of the test tube. A support column is located at the center of the detection groove and at the center of the lower end of the upper plate of the test tube. Multiple sets of optical detectors corresponding to the sample test tubes are arranged between the detection groove and the support column. A limiting component is provided between the upper plate of the test tube and the support column, and the sample test tubes can be quickly assembled and disassembled through the limiting component. A bottom support component is located on the outer side of the lower end of the upper plate of the test tube and is located inside the detection groove. The bottom support component can be used to change the position of the sample test tubes, fix the bottom of the sample test tubes, and rotate the sample test tubes.

[0006] As a preferred embodiment of the present invention, the limiting component includes a connecting rotating seat, the connecting rotating seat is rotatably connected to the top of the support column, and the top of the support column is bolted to a rotating seat cover plate sleeved on the outer side of the upper end of the connecting rotating seat. The outer side of the upper end of the connecting rotating seat is connected to a plurality of fixing pins penetrating the center of the insert plate on the test tube, and the top of the fixing pin is connected to a locking head with a notch at the inner end.

[0007] As a preferred embodiment of the present invention, an external adjusting gear shaft is sleeved on the outside of the fixing pin and the locking head. A locking pin located outside the fixing pin and at the lower end of the locking head is connected to the inner wall of the external adjusting gear shaft. The locking pin and the notch of the locking head are misaligned. A fixing plate that is snapped onto the outer side of the upper end of the test tube insert plate is connected to the side of the upper end of the external adjusting gear shaft near the locking pin.

[0008] As a preferred embodiment of the present invention, an inner adjusting gear shaft meshes between the plurality of external adjusting gear shafts, and the inner adjusting gear shaft is rotatably connected to the center of the upper end of the connecting rotator by bolts and a central column. An adjusting handle is connected to the upper end of the inner adjusting gear shaft, and a limiting pin passes through the inner side of the lower end of the inner adjusting gear shaft, with the lower end of the limiting pin protruding outside the lower end of the inner adjusting gear shaft.

[0009] As a preferred embodiment of the present invention, a limit spring is provided between the upper end of the limiting pin and the inner adjusting gear shaft, and an arc-shaped corner limiting groove coaxial with the inner adjusting gear shaft is provided on the upper end of the connecting rotary seat, and both ends of the corner limiting groove are connected to pin holes. The lower end of the limiting pin is slidably connected inside the corner limiting groove and changes the locking position between the two corner limiting grooves.

[0010] As a preferred embodiment of the present invention, the base assembly includes connecting columns, and the lower end of the upper test tube insert plate is connected to multiple connecting columns, and the lower test tube insert plate is connected through the multiple connecting columns. An outer toothed sleeve is engaged inside the outer end of the lower test tube insert plate, and a drive gear located inside the inner wall of the detection groove is meshed on the outside of the outer toothed sleeve. A drive motor is connected to the lower end of the drive gear. A first one-way limiting spring is provided on the upper end of the rotary cover plate, and multiple teeth are provided on the inner wall of the lower end of the first one-way limiting spring.

[0011] As a preferred embodiment of the present invention, the lower end of the test tube upper insert plate is connected to a plurality of arc-shaped first one-way limiting teeth located inside the first one-way limiting spring, and the other end of the first one-way limiting teeth is attached to the inner wall of the lower end of the first one-way limiting spring, and the engagement position is switched between the plurality of teeth. The lower end of the test tube lower insert plate is connected to a gear sealing plate located at the lower end of the outer gear sleeve by bolts, and a plurality of mixing gears that mesh with the inner wall of the outer gear sleeve are rotatably connected inside the lower end of the test tube lower insert plate.

[0012] As a preferred embodiment of the present invention, a plurality of arc-shaped second one-way limiting spring pieces are engaged inside the lower side of the inner wall of the outer end of the test tube lower insert plate, a second one-way limiting tooth groove is provided on the lower side of the inner wall of the outer tooth sleeve, a plurality of teeth are provided on the inner wall of the second one-way limiting tooth groove, and the other end of the second one-way limiting spring piece is attached to the lower end inner wall of the second one-way limiting tooth groove, and the engagement position is switched between the plurality of teeth, and an elastic base seat extending to the outer side of the upper end of the test tube lower insert plate is provided inside the upper end of the mixing gear.

[0013] As a preferred embodiment of the present invention, the elastic base is wrapped around the bottom of the sample tube, and the lower end of the elastic base is connected to a suction cylinder. The upper end of the suction cylinder is connected to the lower end of the mixing gear, and the lower end of the suction cylinder extends through the gear sealing plate to the inside of the detection groove. A suction piston is slidably connected inside the suction cylinder, and a sealing ring is provided between the suction piston and the suction piston. A pressure boosting push rod extending to the outside of the lower end of the suction cylinder is connected to the lower end of the suction piston.

[0014] As a preferred embodiment of the present invention, the lower end of the pressure boosting push rod is hemispherical, the upper end of the suction piston is provided with a pressure relief spring located inside the suction cylinder, and multiple sets of push rod locking holes with alternating depths are opened on the inner wall of the lower end of the detection groove. The multiple sets of push rod locking holes correspond one-to-one with the positions of multiple optical detectors, and the pressure boosting push rod switches the locking position between the multiple push rod locking holes with alternating depths.

[0015] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0016] 1. This invention utilizes a drive motor, a first one-way limiting spring, a first one-way limiting toothed groove, and a second one-way limiting toothed groove in the base assembly to achieve two rotation modes for the sample tube. By rotating forward, the entire test tube rack is rotated, allowing the sample tube to be precisely moved to the detection position. By rotating in reverse, only the mixing gear is driven to rotate, causing the sample tube to rotate and be shaken in place, ensuring that the inducing agent and blood sample are quickly and evenly mixed, while maintaining the stability of the test tube position, thereby reducing detection errors.

[0017] 2. This invention utilizes the alternating shallow and deep push rod locking holes at the bottom of the detection groove to engage with the pressure boosting push rod and use an elastic base to fix the sample tube. When the sample tube rotates to the detection position, the pressure boosting push rod slides upward as the push rod locking holes become shallower, compressing the gas and causing the elastic base to expand and grip the sample tube, thus achieving automatic fixation. When the sample tube leaves the detection position, the pressure boosting push rod slides downward as the push rod locking holes become shallower, extracting the gas inside the elastic base and contracting, automatically releasing the fixation of the sample tube for easy removal later.

[0018] 3. This invention employs a linkage mechanism consisting of an inner adjusting gear shaft, an outer adjusting gear shaft, locking pins, and a locking head. By rotating the adjusting handle, multiple locking pins can be simultaneously driven to insert from the notch of the locking head to the lower end of the locking head for locking. At the same time, the fixing plate is driven to rotate to the outer side of the center card hole of the test tube insert plate for limiting, thereby quickly completing the installation and fixing of the test tube rack, and can quickly release the fixing for disassembly, improving the efficiency of blood sample handling. Attached Figure Description

[0019] Figure 1 This is a three-dimensional schematic diagram of the platelet aggregation instrument of the present invention;

[0020] Figure 2 This is a schematic diagram of the internal connections of the aggregation detector of the present invention;

[0021] Figure 3 This is a schematic diagram of the internal connection of the detection groove of the present invention;

[0022] Figure 4 This is a schematic diagram of the support column connection of the present invention;

[0023] Figure 5 This is a schematic diagram of the connection of the limiting component of the present invention;

[0024] Figure 6 This is a schematic diagram of the connecting adapter of the present invention;

[0025] Figure 7 This is a schematic diagram of the external adjustment gear shaft connection of the present invention;

[0026] Figure 8 This is a schematic diagram of the connection of the base assembly of the present invention;

[0027] Figure 9 This is a schematic diagram of the test tube lower insert plate connection of the present invention;

[0028] Figure 10 This is a schematic diagram of the external toothed sleeve connection of the present invention;

[0029] Figure 11 This is a schematic diagram of the mixing gear connection of the present invention;

[0030] Figure 12 This is a schematic diagram of the connection of the elastic base support of the present invention.

[0031] The meanings of the labels in the diagram are as follows:

[0032] 1. Aggregation detector; 2. Moving crossbar; 3. Telescopic base; 4. Aspiration needle; 5. Reagent rack; 6. Test tube upper plate; 7. Cleaning cup; 8. Detection slot; 9. Support column; 10. Optical probe; 11. Connecting rotary base; 12. Rotary base cover plate; 13. Fixing pin; 14. Locking head; 15. External adjusting gear shaft; 16. Locking pin; 17. Fixing plate; 18. Internal adjusting gear shaft; 19. Adjusting handle; 20. Limiting pin; 21. Limiting spring; 22. Angle limiter 23. Groove; 24. Locking pin hole; 25. Connecting column; 26. Test tube lower insert plate; 27. Outer gear sleeve; 28. Drive gear; 29. ​​Drive motor; 30. First one-way limiting spring; 31. First one-way limiting tooth groove; 32. Gear sealing plate; 33. Mixing gear; 34. Second one-way limiting spring; 35. Second one-way limiting tooth groove; 36. Elastic base; 37. Suction cylinder; 38. Suction piston; 39. Pressure boosting push rod; 40. Pressure relief spring; 41. Push rod locking hole. Detailed Implementation

[0033] The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0034] In the description of this invention, it should be understood that the terms "center," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," and "counterclockwise," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention.

[0035] Please see Figure 1-12As shown, this embodiment provides a fully automatic platelet aggregator, including an aggregation detector 1 with a movable crossbar 2 slidably connected to it via a screw. A telescopic seat 3 is located outside the movable crossbar 2, and an aspiration needle 4 penetrates vertically inside the telescopic seat 3. A reagent rack 5 for holding various reagent bottles is located on one side of the bottom of the aggregation detector 1's inner cavity, and a test tube insert 6 for holding various sample tubes is located on the other side of the bottom of the aggregation detector 1's inner cavity. A cleaning cup 7 is located inside the bottom of the aggregation detector 1's inner cavity between the reagent rack 5 and the test tube insert 6. A detection groove 8 is located at the bottom of the aggregation detector 1's inner cavity and outside the lower end of the test tube insert 6, between the test tube insert 6 and the aggregation detector 1. A support column 9 is located at the center of the lower end of the test tube insert 6, with multiple sets of optical detector probes 10 corresponding to the sample tubes, are located between the detection groove 8 and the support column 9. A limit assembly is provided between the test tube insert 6 and the support column 9, and... The limiting component allows for quick assembly and disassembly. A base support assembly located inside the detection slot 8 is provided on the outer side of the lower end of the test tube upper plate 6. This base support assembly can change the position of the sample test tube and fix its bottom, and can also rotate the sample test tube. During platelet aggregation detection, the aggregation detector 1 is electrically connected to an external power source via a wiring harness. The aggregation detector 1 consists of a detection chamber and a control chamber. The moving crossbar 2 is located inside the detection chamber, and a sealing door is provided at the opening of the detection chamber. Opening the sealing door allows multiple reagent bottles containing various inducing agents to be placed inside the reagent rack 5, and the reagent rack 5 to be placed inside the bottom side of the aggregation detector 1. The test tube upper plate 6 is inserted into the detection slot 8 and quickly fixed to the upper end of the support column 9 via the limiting component. Multiple sample test tubes for holding blood samples are then inserted into the test tube upper plate 6. Finally, a washing cup 7 for holding washing solution is placed inside the bottom of the aggregation detector 1 between the reagent rack 5 and the test tube upper plate 6, and the sealing door is closed.

[0036] Furthermore, by controlling the base assembly to rotate forward, the base assembly drives the test tube insert plate 6 to rotate, and the test tube insert plate 6 rotates the sample test tubes to the position of each group of optical detectors 10, while simultaneously fixing multiple sample test tubes. At this time, the aspiration needle 4 moves inside the aggregation detector 1 through the moving crossbar 2 and the telescopic seat 3, and sequentially introduces the inducing agent from the reagent bottle inside the reagent rack 5 into the multiple sample test tubes inside the test tube insert plate 6 as needed, thereby mixing the blood sample and the inducing agent inside the sample test tubes. This causes the platelets in the blood sample to aggregate under the action of the inducing agent, reduces the turbidity of the blood sample, and increases the light transmittance of the blood sample. During the introduction of the inducing agent, the aspiration needle 4 can extend and retract through the telescopic seat 3 and aspirate the inducing agent, and can be soaked and cleaned by the cleaning solution inside the cleaning cup 7, ensuring that the various inducing agents do not contaminate each other.

[0037] Furthermore, by controlling the initiation of the bottom support assembly to reverse, the bottom support assembly drives the sample tube to rotate, causing the blood sample and inducing agent inside the sample tube to rotate and be shaken evenly under the influence of the sample tube. This allows multiple sample tubes to be shaken synchronously and efficiently, ensuring that the inducing agent can be quickly and evenly mixed with the blood sample. This ensures that the blood sample aggregation initiation time is uniform, reducing detection errors. Since each set of photodetectors 10 consists of a light source and a photoelectric sensor, and is distributed one-to-one on the inner cylindrical wall of the detection slot 8 and the outer cylindrical wall of the support column 9, when the sample tube rotates to the position of each set of photodetectors 10, the photodetector 10 can perform real-time detection and data acquisition of the turbidity and transmittance of the blood sample, and generate an aggregation curve, thereby completing the detection.

[0038] Furthermore, after the test is completed, multiple reagent tubes containing various inducing agents can be efficiently removed together through the reagent rack 5, and multiple sample tubes containing blood samples can be efficiently removed together through the tube insert 6. The tube insert 6 can be quickly separated from the support column 9 through the limiting component, ensuring that the tube insert 6 can be smoothly removed.

[0039] In addition, the base assembly is rotated forward again, which drives the test tube upper plate 6 to rotate, so that multiple sample tubes inside the test tube upper plate 6 are moved away from the positions of multiple sets of optical detectors 10, and the fixation of the sample tubes is released, so that the sample tubes can be taken out individually from inside the test tube upper plate 6 for continuous testing.

[0040] like Figures 2-7As shown, the limiting assembly includes a connecting rotary seat 11. The connecting rotary seat 11 is rotatably connected to the top of the support column 9, and a rotary seat cover plate 12, which is sleeved on the outer side of the upper end of the connecting rotary seat 11, is bolted to the top of the support column 9. Multiple fixing pins 13, which pass through the center of the test tube insert plate 6, are connected to the outer side of the upper end of the connecting rotary seat 11. A locking head 14 with a notch at the inner end is connected to the top of the fixing pin 13. An external adjusting gear shaft 15 is sleeved on the outside of the fixing pin 13 and the locking head 14. A locking pin 16 is connected to the inner wall of shaft 15, located outside the fixing pin 13 and at the lower end of the locking head 14. The locking pin 16 and the notch of the locking head 14 are misaligned. A fixing plate 17 is connected to the upper end of the external adjusting gear shaft 15 near the locking pin 16, which is snapped onto the outer side of the upper end of the center of the test tube insert plate 6. Multiple external adjusting gear shafts 15 are meshed with internal adjusting gear shafts 18, and the internal adjusting gear shafts 18 are rotatably connected to the upper center of the connecting rotary seat 11 by bolts and a central column. The upper end of the adjusting gear shaft 18 is connected to the adjusting handle 19, and a limit pin 20 passes through the inner side of the lower end of the inner adjusting gear shaft 18. The lower end of the limit pin 20 protrudes outside the lower end of the inner adjusting gear shaft 18. A limit spring 21 is provided between the upper end of the limit pin 20 and the inner adjusting gear shaft 18. The upper end of the connecting rotary seat 11 is provided with an arc-shaped corner limiting groove 22 coaxial with the inner adjusting gear shaft 18, and both ends of the corner limiting groove 22 are connected to pin holes 23. The lower end of the limit pin 20 is slidably connected. Inside the corner limiting groove 22, and by switching the snap-fit ​​position between the two corner limiting grooves 22, during the process of quickly assembling and disassembling the test tube upper plate 6, the test tube upper plate 6 is placed on the upper end of the connecting pivot 11 inside the upper end of the support column 9, and multiple fixing pins 13 and multiple locking heads 14 are inserted into the center snap-fit ​​hole of the test tube upper plate 6. Then, the external adjusting gear shaft 15 is inserted into the center snap-fit ​​hole of the test tube upper plate 6, and simultaneously sleeved onto the upper outside of the fixing pins 13 and locking heads 14.

[0041] During the process of attaching the outer adjusting gear shaft 15 to the upper exterior of the fixing pin 13 and the locking head 14, the locking pin 16 on the inner wall of the outer adjusting gear shaft 15 is aligned with the notch on the inner side of the locking head 14 and inserted into the notch of the locking head 14 to position the fixing plate 17. Then, the inner adjusting gear shaft 18 is fixed between the multiple outer adjusting gear shafts 15 by bolts. Then, the inner adjusting gear shaft 18 is rotated by the adjusting handle 19, so that the inner adjusting gear shaft 18 drives the multiple outer adjusting gear shafts 15 to rotate through the meshing between the inner adjusting gear shaft 18 and the outer adjusting gear shaft 15.

[0042] At this time, the locking pin 16 rotates from the notch position of the locking head 14 to the outer side of the lower end of the locking head 14 under the drive of the external adjusting gear shaft 15, and is blocked and limited by the locking head 14. At the same time, the fixing plate 17 rotates to the outer side of the center hole of the test tube upper plate 6 under the drive of the external adjusting gear shaft 15, thereby fixing the position of the test tube upper plate 6.

[0043] Meanwhile, the limiting pin 20 located inside the lower end of the inner adjusting gear shaft 18 slides from one end of the corner limiting groove 22 to the other end and is ejected from the pin hole 23 at one end. At the same time, under the elastic action of the limiting spring 21, it is inserted into the pin hole 23 at the other end for limiting. This can limit the rotation angle of the outer adjusting gear shaft 15 and the inner adjusting gear shaft 18, ensuring that the fixed plate 17 after positioning can rotate smoothly to the outer side of the center pin hole of the test tube upper plate 6. It can also limit the position of the inner adjusting gear shaft 18, ensuring the stable fixation of the test tube upper plate 6.

[0044] Furthermore, after the test tube insert 6 is fixed to the upper end of the connecting rotor 11, the test tube insert 6 can rotate with the support column 9 through the connecting rotor 11, and the connecting rotor 11 can be limited inside the upper end of the support column 9 by the rotor cover 12, and can rotate inside the support column 9 and the rotor cover 12.

[0045] like Figure 8 , Figure 9 and Figure 11 As shown, the base assembly includes connecting posts 24. Multiple connecting posts 24 are connected to the lower end of the upper test tube insert plate 6, and a lower test tube insert plate 25 is connected via these connecting posts 24. An outer gear sleeve 26 is snapped into the inner part of the outer end of the lower test tube insert plate 25. A gear sealing plate 31 located at the lower end of the outer gear sleeve 26 is bolted to the lower end of the lower test tube insert plate 25. Multiple mixing gears 32, which mesh with the inner wall of the outer gear sleeve 26, are rotatably connected to the inner part of the lower end of the lower test tube insert plate 25. An extension extending to the lower test tube insert plate is provided inside the upper end of the mixing gears 32. The upper outer part of the plate 25 has an elastic base 35, which wraps around the bottom of the sample tube. During the placement of the sample tube, the upper insert plate 6 is connected to the lower insert plate 25 of the sample tube through the connecting post 24 to form a whole and a ring-shaped test tube rack. At this time, the sample tube is inserted into the upper insert plate 6, and the bottom of the sample tube is inserted into the mixing gear 32 inside the lower insert plate 25, and then inserted into the elastic base 35 inside the mixing gear 32 for support and limitation.

[0046] like Figures 8-11As shown, the outer gear sleeve 26 is externally meshed with a drive gear 27 located inside the inner wall of the detection groove 8. The lower end of the drive gear 27 is connected to a drive motor 28. The upper end of the rotary cover plate 12 is provided with a first one-way limiting spring 29, and multiple teeth are provided on the lower inner wall of the first one-way limiting spring 29. The lower end of the test tube insert plate 6 is connected to multiple arc-shaped first one-way limiting tooth grooves 30 located inside the first one-way limiting spring 29, and the other end of the first one-way limiting tooth groove 30 is attached to... The first one-way limiting spring 29 is attached to the inner wall of its lower end, and the locking position changes between multiple teeth. Multiple arc-shaped second one-way limiting springs 33 are locked inside the lower side of the inner wall of the outer end of the test tube lower insert plate 25. A second one-way limiting tooth groove 34 is opened on the lower side of the inner wall of the outer toothed sleeve 26. Multiple teeth are provided on the inner wall of the second one-way limiting tooth groove 34, and the other end of the second one-way limiting spring 33 is attached to the inner wall of the lower end of the second one-way limiting tooth groove 34, and the locking position changes between multiple teeth. During the forward rotation of the test tube upper insert plate 6, the drive motor 28 is electrically connected to the control chamber of the aggregation detector 1 via a wiring harness. The control chamber can control the rotation of the drive motor 28. The drive motor 28 drives the outer gear sleeve 26 to rotate forward through the meshing between the drive gear 27 and the outer gear sleeve 26. At this time, because the arc-shaped second one-way limiting spring piece 33, at one end away from the lower insert plate 25 of the test tube, is in contact with the inner wall of the second one-way limiting tooth groove 34, and the outer... The direction of the toothed sleeve 26 is the same as the direction of the second one-way limiting spring 33 from the end near the test tube lower insert plate 25 to the end away from the test tube lower insert plate 25. Therefore, when the outer toothed sleeve 26 rotates forward, the second one-way limiting spring 33 engages with the teeth on the inner wall of the second one-way limiting tooth groove 34, so that the test tube lower insert plate 25 and the outer toothed sleeve 26 can be locked together by multiple second one-way limiting springs 33, and drive the outer toothed sleeve 26 to rotate forward together, and drive the entire test tube rack to rotate forward together.

[0047] At the same time, the direction of the overall forward rotation of the test tube rack is consistent with the direction of the first one-way limiting spring 29 near the first one-way limiting tooth groove 30 pointing near the test tube upper insertion plate 6. Therefore, the first one-way limiting spring 29 will slide along the teeth on the inner wall of the first one-way limiting tooth groove 30 and will not lock the test tube upper insertion plate 6 and the rotating cover plate 12, so that the test tube rack can rotate forward under the drive of the drive gear 27 and drive the sample test tube to the position of each group of optical probes 10, and rotate again to move away from the position of each group of optical probes 10.

[0048] Furthermore, during the process of rotating and mixing the sample tube, when the drive motor 28 reverses, the drive motor 28 drives the outer gear sleeve 26 to reverse through the drive gear 27. The direction of the outer gear sleeve 26's reversal is opposite to the direction of the second one-way limiting spring 33 from the end near the lower insert plate 25 of the test tube to the end away from the lower insert plate 25 of the test tube. Therefore, the second one-way limiting spring 33 can slide on the teeth of the inner wall of the second one-way limiting groove 34, and will not lock the lower insert plate 25 of the test tube and the outer gear sleeve 26. This allows the outer gear sleeve 26 to drive multiple mixing gears 32 and the elastic base 35 to rotate inside the lower insert plate 25 through meshing with the mixing gear 32, and drive the sample tube to rotate and mix through the elastic base 35.

[0049] At the same time, the reverse direction of the outer toothed sleeve 26 is opposite to the direction of the first one-way limiting spring 29 near the end of the first one-way limiting tooth groove 30 pointing near the end of the test tube upper insert plate 6. Therefore, the first one-way limiting spring 29 will engage with the teeth on the inner wall of the first one-way limiting tooth groove 30 to lock the test tube upper insert plate 6 and the rotating cover plate 12. This prevents the test tube rack from rotating under the friction force between the outer toothed sleeve 26 and the test tube lower insert plate 25 and the gear sealing plate 31, as well as the rolling resistance between the outer toothed sleeve 26 and the multiple mixing gears 32. This allows the drive gear 27 to keep the test tube rack in place while rotating and shaking the sample test tube, ensuring that the sample test tube is always at the position of the optical detector 10 during the rotation and shaking process, thus avoiding detection errors.

[0050] like Figure 3 , Figure 11 and Figure 12 As shown, the lower end of the elastic base 35 is connected to a suction cylinder 36. The upper end of the suction cylinder 36 is connected to the lower end of the mixing gear 32, and the lower end of the suction cylinder 36 extends through the gear sealing plate 31 into the detection groove 8. A suction piston 37 is slidably connected inside the suction cylinder 36, and a sealing ring is provided between the suction piston 37 and the piston. The lower end of the suction piston 37 is connected to a pressure boosting push rod 38 extending to the outside of the lower end of the suction cylinder 36. The lower end of the pressure boosting push rod 38 is hemispherical. A pressure relief spring 39 located inside the suction cylinder 36 is provided at the upper end of the suction piston 37. Multiple sets of push rod locking holes 40 with alternating depths are provided on the inner wall of the lower end of the detection groove 8. The positions of the 40 and multiple optical detectors 10 are one-to-one. The pressure push rod 38 changes its locking position among multiple push rod locking holes 40 with alternating depths. During the process of fixing the sample tube, when the sample tube is just placed inside the test tube rack, the pressure push rod 38 is locked inside the deeper push rod locking hole 40. When the sample tube is rotated to the position of the optical detector 10 by the test tube rack, the pressure push rod 38 is rotated from the deeper push rod locking hole 40 to the shallower push rod locking hole 40 by the test tube rack. This allows the hemispherical end of the pressure push rod 38 to exit from the deeper push rod locking hole 40 and lock into the shallower push rod locking hole 40.

[0051] At this time, the pressurizing push rod 38 will slide upward inside the suction cylinder 36, and drive the suction piston 37 to slide upward inside the suction cylinder 36, squeezing the gas inside the upper end of the suction cylinder 36 into the elastic base 35, causing the elastic base 35 to expand due to increased pressure, and then tightly adhering to the outer wall of the sample tube through expansion, thereby fixing the sample tube and ensuring that the sample tube will not detach during the rotation of the mixing gear 32 and the elastic base 35.

[0052] Conversely, when the test tube rack is rotated again and the sample tube is moved away from the position of the optical probe 10, the hemispherical end of the lower end of the pressure boosting rod 38 is dislodged from the shallower push rod locking hole 40 and inserted into the deeper push rod locking hole 40. This allows the suction piston 37 and the pressure boosting rod 38 to slide downward inside the suction cylinder 36, drawing the gas inside the elastic base 35 back into the suction cylinder 36. This causes the elastic base 35 to depressurize and contract, releasing the tight fit with the sample tube and facilitating the individual removal of the sample tube.

[0053] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely preferred examples and are not intended to limit the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of the present invention as claimed. The scope of protection of the present invention is defined by the appended claims and their equivalents.

Claims

1. A fully automatic platelet aggregator, comprising an aggregator (1) with a movable crossbar (2) slidably connected to it via a screw, and a telescopic seat (3) provided outside the movable crossbar (2), wherein an aspiration needle (4) is vertically inserted through the telescopic seat (3), a reagent rack (5) for placing various different reagent bottles is provided inside one side of the bottom of the aggregator (1), and a test tube insert plate (6) for placing various different sample tubes is provided inside the other side of the bottom of the aggregator (1), and a cleaning cup (7) located inside the bottom of the aggregator (1) is provided between the reagent rack (5) and the test tube insert plate (6), characterized in that: A detection groove (8) is provided between the test tube upper plate (6) and the aggregation detector (1), which is located at the bottom of the inner cavity of the aggregation detector (1) and outside the lower end of the test tube upper plate (6). A support column (9) is provided at the center of the inner cavity of the detection groove (8) and at the center of the lower end of the test tube upper plate (6). Multiple sets of light detection probes (10) corresponding to the sample test tubes are provided between the detection groove (8) and the support column (9). A limiting component is provided between the test tube insert plate (6) and the support column (9), and the limiting component allows for quick assembly and disassembly. The test tube upper plate (6) is provided with a bottom support assembly located inside the detection groove (8) on the outer side of the lower end. The bottom support assembly can change the position of the sample test tube and fix the bottom of the sample test tube, and can rotate the sample test tube.

2. The fully automated platelet aggregation analyzer according to claim 1, characterized in that: The limiting component includes a connecting rotating seat (11), the top of the support column (9) is rotatably connected to the connecting rotating seat (11), and the top of the support column (9) is bolted to a rotating seat cover plate (12) sleeved on the outer side of the upper end of the connecting rotating seat (11). The outer side of the upper end of the connecting rotating seat (11) is connected to a plurality of fixing pins (13) that pass through the center of the test tube insert plate (6), and the top of the fixing pin (13) is connected to a locking head (14) with a notch at the inner end.

3. The fully automated platelet aggregation analyzer according to claim 2, characterized in that: The fixing pin (13) and the locking head (14) are externally sleeved with an external adjusting gear shaft (15). The inner wall of the external adjusting gear shaft (15) is connected to a locking pin (16) located outside the fixing pin (13) and at the lower end of the locking head (14). The locking pin (16) and the notch of the locking head (14) are misaligned. The upper end of the external adjusting gear shaft (15) near the locking pin (16) is connected to a fixing plate (17) that is snapped onto the outer side of the upper end of the test tube insert plate (6).

4. The fully automated platelet aggregation analyzer according to claim 3, characterized in that: An internal adjusting gear (18) meshes between multiple external adjusting gear shafts (15), and the internal adjusting gear shaft (18) is rotatably connected to the upper center of the connecting rotator (11) by bolts and a central column. An adjusting handle (19) is connected to the upper end of the internal adjusting gear shaft (18), and a limiting pin (20) passes through the lower outer side of the internal adjusting gear shaft (18). The lower end of the limiting pin (20) protrudes outside the lower end of the internal adjusting gear shaft (18).

5. The fully automated platelet aggregation analyzer according to claim 4, characterized in that: A limit spring (21) is provided between the upper end of the limit pin (20) and the inner adjusting gear shaft (18). The upper end of the connecting rotary seat (11) is provided with an arc-shaped corner limiting groove (22) coaxial with the inner adjusting gear shaft (18), and both ends of the corner limiting groove (22) are connected to pin holes (23). The lower end of the limit pin (20) is slidably connected inside the corner limiting groove (22) and changes the locking position between the two corner limiting grooves (22).

6. The fully automated platelet aggregation analyzer according to claim 2, characterized in that: The base assembly includes connecting posts (24), the lower end of the test tube upper insert plate (6) is connected to multiple connecting posts (24), and the test tube lower insert plate (25) is connected through multiple connecting posts (24). The lower insert plate (25) is internally engaged with an external toothed sleeve (26), and the external toothed sleeve (26) is meshed with a drive gear (27) located inside the inner wall of the detection groove (8). The lower end of the drive gear (27) is connected to a drive motor (28). The upper end of the rotary cover plate (12) is provided with a first one-way limiting spring (29), and the lower inner wall of the first one-way limiting spring (29) is provided with multiple teeth.

7. The fully automated platelet aggregation analyzer according to claim 6, characterized in that: The lower end of the test tube upper insert plate (6) is connected to a plurality of arc-shaped first one-way limiting tooth grooves (30) located inside the first one-way limiting spring (29), and the other end of the first one-way limiting tooth groove (30) is attached to the inner wall of the lower end of the first one-way limiting spring (29), and the engagement position is changed between the plurality of teeth. The lower end of the test tube lower insert plate (25) is connected to a gear sealing plate (31) located at the lower end of the outer tooth sleeve (26) by bolts, and a plurality of mixing gears (32) that mesh with the inner wall of the outer tooth sleeve (26) are rotatably connected inside the lower end of the test tube lower insert plate (25).

8. The fully automated platelet aggregation analyzer according to claim 7, characterized in that: The lower inner wall of the outer end of the test tube insert plate (25) is fitted with multiple arc-shaped second one-way limiting spring pieces (33). The lower inner wall of the outer toothed sleeve (26) is provided with a second one-way limiting tooth groove (34). Multiple teeth are provided on the inner wall of the second one-way limiting tooth groove (34), and the other end of the second one-way limiting spring piece (33) is attached to the lower inner wall of the second one-way limiting tooth groove (34) and the locking position is changed between multiple teeth. The upper end of the mixing gear (32) is provided with an elastic base support (35) extending to the upper outside of the test tube insert plate (25).

9. The fully automated platelet aggregation analyzer according to claim 8, characterized in that: The elastic base (35) is wrapped around the bottom of the sample tube, and the lower end of the elastic base (35) is connected to the suction cylinder (36). The upper end of the suction cylinder (36) is connected to the lower end of the mixing gear (32), and the lower end of the suction cylinder (36) extends through the gear sealing plate (31) to the inside of the detection groove (8). The suction cylinder (36) is slidably connected to the suction piston (37), and a sealing ring is provided between the suction piston (37) and the suction piston (37). The lower end of the suction piston (37) is connected to a pressure boosting push rod (38) extending to the outside of the lower end of the suction cylinder (36).

10. A fully automated platelet aggregation analyzer according to claim 9, characterized in that: The lower end of the booster push rod (38) is hemispherical. The upper end of the suction piston (37) is provided with a pressure relief spring (39) located inside the suction cylinder (36). Multiple sets of push rod locking holes (40) with alternating depths are opened on the inner wall of the lower end of the detection groove (8). The multiple sets of push rod locking holes (40) correspond one-to-one with the positions of multiple optical detectors (10). The booster push rod (38) switches the locking position between the multiple push rod locking holes (40) with alternating depths.

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