A pesticide composition containing quinolinol copper and validamycin and a preparation thereof

Abstract

The application provides a pesticide composition containing quinolinol copper and validamycin and a preparation thereof, and comprises effective components 20-70%, polycarboxylate dispersant 1.0-5.0%, lignin sulfonate dispersant 0.5-4.0%, protective colloid 0.2-2.0%, sugar protective agent 0.5-5.0%, mineral stabilizer 0.1-10.0% and the rest of preparation auxiliaries and carriers according to the total mass of the pesticide preparation; the effective components consist of quinolinol copper and validamycin, the mass ratio of the quinolinol copper to the validamycin is 3:1-5:1; the pesticide preparation is a suspension agent, a water dispersible granule or a wettable powder; the application forms a preparation stable system through polyvinylpyrrolidone, trehalose and mineral stabilizer, the polyvinylpyrrolidone and the trehalose are used for coordinating the system in which the validamycin is located, the magnesium aluminum silicate, white carbon black or other mineral stabilizers are used for maintaining the suspension or solid dispersion state of the preparation, and the sedimentation, caking and the decline of the redispersion performance in the storage process are reduced.

Description

Technical Field

[0001] This invention relates to the field of pesticide compositions and pesticide formulations, and particularly to a pesticide composition and formulation containing quinoline copper and jinggangmycin. Background Technology

[0002] Quinoline copper is a copper-containing organic fungicide with low solubility in water. When formulated as a pesticide, it is typically dispersed in the aqueous phase or on a solid carrier as solid particles. It can be used to control fungal and bacterial diseases in crops. Jinggangmycin is an agricultural antibiotic primarily used to control sheath blight, damping-off, and related fungal diseases caused by Rhizoctonia solani. Combining these two active ingredients allows for the addressing of different disease control needs while reducing the need for separate preparation and multiple applications.

[0003] In the prior art, CN102669100A discloses a pesticide composition of quinoline copper and jinggangmycin, its preparation method and uses. The composition can be made into wettable powder, suspension or water-dispersible granules and used for the control of fungal and bacterial diseases of plants. CN101147492A discloses a fungicide of copper sulfate and jinggangmycin and its application method, indicating that the technical idea of ​​using copper-containing fungicides and jinggangmycin for the control of crop diseases already exists. The above schemes mainly focus on the combination of active ingredients, mass ratio and conventional formulation, and do not involve much about the differences in physical properties of the two active ingredients and the compatibility between the formulation adjuvant system.

[0004] Because quinoline copper is poorly soluble in water, while jinggangmycin is readily distributed in the aqueous phase, the two exist in different states in the same formulation. When using common dispersants and carriers for formulation, quinoline copper particles are prone to aggregation, sedimentation, or decreased redispersibility after storage in suspensions. Water-dispersible granules and wettable powders may experience problems such as moisture absorption and clumping, wetting, or decreased disintegration rate.

[0005] Therefore, a pesticide composition containing quinoline copper and jinggangmycin and its formulation are proposed. Summary of the Invention

[0006] In view of this, the present invention provides a pesticide composition containing quinoline copper and jinggangmycin and its formulation, to solve or alleviate the technical problems existing in the prior art, and at least provide a beneficial alternative.

[0007] The technical solution of the present invention is implemented as follows: a pesticide composition containing quinoline copper and jinggangmycin, wherein the active ingredient of the pesticide composition is composed of quinoline copper and jinggangmycin, and the mass ratio of quinoline copper to jinggangmycin is 2:1 to 8:1.

[0008] The mass ratio of quinoline copper to jinggangmycin can be 3:1 to 5:1.

[0009] In one specific composition, the mass ratio of quinoline copper to jinggangmycin is 15:4.

[0010] The present invention also provides a pesticide formulation containing quinoline copper and jinggangmycin. The pesticide formulation comprises, by total mass, 20%–70% active ingredient, 1.0%–5.0% polycarboxylate dispersant, 0.5%–4.0% lignin sulfonate dispersant, 0.2%–2.0% protective colloid, 0.5%–5.0% saccharide protectant, 0.1%–10.0% mineral stabilizer, and the balance being formulation excipients and carrier.

[0011] The active ingredient consists of quinoline copper and jinggangmycin, with a mass ratio of quinoline copper to jinggangmycin of 3:1 to 5:1.

[0012] The protective colloid is selected from one or more of polyvinylpyrrolidone, hydroxypropyl methylcellulose, and polyvinyl alcohol.

[0013] The sugar protectant is selected from one or more of trehalose, sorbitol, mannitol and soluble starch.

[0014] The mineral stabilizer is selected from one or more of magnesium aluminum silicate, attapulgite, bentonite, and silica.

[0015] The pesticide formulation can be a suspension concentrate, a water-dispersible granule, or a wettable powder.

[0016] In a specific composition of active ingredients, based on the total mass of the pesticide formulation, the mass percentage of quinoline copper is 30%, the mass percentage of jinggangmycin is 8%, and the total mass percentage of active ingredients is 38%.

[0017] When the pesticide formulation is a suspension concentrate, it comprises, by total mass, 30% quinoline copper, 8% jinggangmycin, 1.5%–3.5% polycarboxylate dispersant, 1.0%–2.5% lignin sulfonate dispersant, 0.3%–1.2% alkyl glycoside wetting agent, 0.3%–1.0% polyvinylpyrrolidone, 1.0%–3.0% trehalose, 3.0%–6.0% propylene glycol, 0.3%–0.8% magnesium aluminum silicate, 0.1%–0.3% xanthan gum, 0.1%–0.5% buffering agent, 0.05%–0.3% preservative, 0.05%–0.3% defoamer, and the balance being water.

[0018] In the suspending agent, the particle size D90 corresponding to the cumulative volume distribution of quinoline copper particles reaching 90% is 2μm to 6μm, and the pH value of the suspending agent is 6.2 to 6.8.

[0019] In a specific suspension composition, by total mass of the suspension, it includes 30.00% quinoline copper, 8.00% jinggangmycin, 2.40% polycarboxylate dispersant, 1.60% sodium lignosulfonate, 0.80% alkyl glycoside wetting agent, 0.60% polyvinylpyrrolidone, 2.00% trehalose, 4.00% propylene glycol, 0.50% magnesium aluminum silicate, 0.18% xanthan gum, 0.25% buffer conditioner composed of acetic acid and sodium acetate, 0.15% sodium benzoate, 0.20% organosilicon defoamer, and 49.32% deionized water.

[0020] When the pesticide formulation is a water-dispersible granule, it comprises, by total mass of water-dispersible granules, 30% quinoline copper, 8% jinggangmycin, 3%–5% polycarboxylate dispersant, 2%–4% lignin sulfonate dispersant, 0.5%–1.5% polyvinylpyrrolidone, 3%–5% trehalose, 1%–3% alkylnaphthalene sulfonate wetting agent, 8%–12% soluble starch, 6%–10% sodium sulfate, 0.5%–2.0% silica, and the balance being kaolin.

[0021] When the pesticide formulation is a wettable powder, it comprises, by total mass of wettable powder, 30% quinoline copper, 8% jinggangmycin, 2%–4% polycarboxylate dispersant, 3%–5% lignosulfonate dispersant, 0.5%–1.5% polyvinylpyrrolidone, 3%–5% trehalose, 1%–2% sodium dodecyl sulfate, 6%–10% silica, 8%–12% diatomaceous earth, and the balance kaolin.

[0022] The pesticide composition and pesticide formulation can be used for the prevention and control of fungal and bacterial diseases of crops. Among them, jinggangmycin is used to prevent and control fungal diseases caused by Rhizoctonia solani, and quinoline copper is used to prevent and control bacterial diseases of crops and plays a supplementary role in the prevention and control of some fungal diseases.

[0023] The embodiments of the present invention have the following advantages due to the adoption of the above technical solutions:

[0024] I. This invention uses polycarboxylate dispersant and lignin sulfonate dispersant in combination. The two types of dispersants work together on the surface of quinoline copper particles, which helps to reduce the tendency of particles to aggregate and keeps quinoline copper in a relatively uniform dispersion state in aqueous phase or solid carrier.

[0025] II. The present invention uses polyvinylpyrrolidone, trehalose and mineral stabilizers to form a formulation stabilization system. Polyvinylpyrrolidone and trehalose are used to coordinate the system containing jinggangmycin, while magnesium aluminum silicate, silica or other mineral stabilizers are used to maintain the suspension or solid dispersion state of the formulation and reduce sedimentation, agglomeration and redispersibility during storage.

[0026] Third, this invention combines quinoline copper and jinggangmycin in a specified ratio, enabling the same formulation to treat both Rhizoctonia solani fungal diseases and bacterial diseases of crops, reducing the additional operational steps required by preparing and applying two single agents separately. Detailed Implementation

[0027] This invention provides a pesticide composition and formulation containing quinoline copper and jinggangmycin. The pesticide composition uses quinoline copper and jinggangmycin as active ingredients, and the formulation includes a suspension concentrate, water-dispersible granules, or wettable powder. To address the difference in physical properties between quinoline copper (poorly soluble in water and mainly existing as solid particles) and jinggangmycin (easily distributed in the aqueous phase), polycarboxylate dispersants, lignin sulfonate dispersants, protective colloids, sugar protectants, and mineral stabilizers are added to the formulation to coordinate the dispersion and storage states of the two active ingredients.

[0028] Example 1

[0029] The composition of the suspending agent in this embodiment is shown in Table 1.

[0030] Table 1. Components and content of the suspending agent in Example 1 Quinoline copper 30.00% Jinggangmycin 8.00% polycarboxylate dispersants 2.40% Sodium lignosulfonate 1.60% Alkyl glycoside wetting agents 0.80% Polyvinylpyrrolidone K30 0.60% Trehalose 2.00% Propylene glycol 4.00% Magnesium aluminum silicate 0.50% Xanthan Gum 0.18% Acetic acid-sodium acetate buffer 0.25% Sodium benzoate 0.15% silicone defoamer 0.20% Deionized water 49.32% total 100.00%

[0031] In preparation, about 60% of the formula amount of deionized water is first added to the dispersion vessel. Under stirring, polycarboxylate dispersant, sodium lignosulfonate, alkyl glycoside wetting agent and half of the formula amount of organosilicon defoamer are added in sequence. After the components are evenly dispersed, quinoline copper is added. The material is sheared at 1500r / min to 2500r / min for 15min to 30min to fully wet the quinoline copper technical. Then it is sent to a sand mill for circulating grinding. During the grinding process, the material temperature is controlled below 35℃ until the D90 of the quinoline copper particles reaches 2μm to 6μm to obtain quinoline copper dispersion.

[0032] Take a separate portion of deionized water, add polyvinylpyrrolidone K30 and trehalose, stir until dissolved, then add jinggangmycin, controlling the liquid temperature not to exceed 30℃, and continue stirring until the material is homogeneous to obtain a jinggangmycin mixture. Jinggangmycin should not be introduced into the sand mill along with quinoline copper.

[0033] The jinggangmycin mixture was slowly added to the quinoline copper dispersion, with the stirring speed controlled at 300 r / min to 600 r / min. Magnesium aluminum silicate and xanthan gum were pre-hydrated with deionized water and then added to the mixture in sequence. Propylene glycol, sodium benzoate, acetate-sodium acetate buffer, and the remaining organosilicon defoamer were then added. The mixture was made up to the total volume with deionized water, stirred evenly, and the pH of the preparation was tested and adjusted to 6.2 to 6.8. After filtration, a suspension containing 30% quinoline copper and 8% jinggangmycin was obtained.

[0034] In this embodiment, the mass ratio of quinoline copper to jinggangmycin is 15:4. After wetting and grinding, quinoline copper is dispersed in the continuous aqueous phase as fine particles. Jinggangmycin is added after the quinoline copper is ground. Polyvinylpyrrolidone and trehalose enter the formulation system along with jinggangmycin. Magnesium aluminum silicate and xanthan gum form a suspension stabilizing network to slow down the sedimentation of quinoline copper particles.

[0035] Example 2

[0036] The composition of the suspending agent in this embodiment is shown in Table 2.

[0037] Table 2. Components and content of the suspending agent in Example 2 Quinoline copper 30.00% Jinggangmycin 8.00% polycarboxylate dispersants 2.20% Sodium lignosulfonate 1.40% Alkyl glycoside wetting agents 0.60% Hydroxypropyl methylcellulose 0.50% Mannitol 2.00% Propylene glycol 4.00% Bentonite 0.60% Xanthan Gum 0.20% Buffer regulator 0.30% Sodium benzoate 0.15% silicone defoamer 0.20% Deionized water 49.85% total 100.00%

[0038] In preparation, polycarboxylate dispersant, sodium lignosulfonate, and alkyl glycoside wetting agent were first added to a portion of deionized water. Quinoline copper was then added, followed by shearing and milling to achieve a D90 of 2μm–6μm for the quinoline copper particles. Hydroxypropyl methylcellulose and mannitol were dispersed in another portion of deionized water, and jinggangmycin was added and mixed thoroughly. This mixture was then added to the milled quinoline copper dispersion. Finally, pre-hydrated bentonite and xanthan gum were added, along with propylene glycol, a buffer regulator, sodium benzoate, and an organosilicon defoamer. The mixture was then brought to the final volume with deionized water.

[0039] Example 3

[0040] The composition of the water-dispersible granules in this embodiment is shown in Table 3.

[0041] Table 3. Components and content of water-dispersible granules in Example 3 Quinoline copper 30.00% Jinggangmycin 8.00% polycarboxylate dispersants 4.00% Sodium lignosulfonate 3.00% Polyvinylpyrrolidone K30 1.00% Trehalose 4.00% Alkyl naphthalene sulfonate wetting agent 2.00% Soluble starch 10.00% Sodium sulfate 8.00% precipitate 1.00% Kaolin 29.00% total 100.00%

[0042] Quinoline copper, polycarboxylate dispersant, sodium lignosulfonate, fumed silica and some kaolin are mixed and pulverized until the material can pass through a sieve of appropriate fineness to obtain quinoline copper premix powder.

[0043] Jinggangmycin, polyvinylpyrrolidone K30, trehalose, and soluble starch were mixed to obtain a jinggangmycin premix. The jinggangmycin premix was not subjected to high-energy pulverization together with quinoline copper to reduce the mechanical action on jinggangmycin during the pulverization process and to prevent jinggangmycin from concentrating and adhering to the surface of quinoline copper fine particles.

[0044] Quinoline copper premix powder, jinggangmycin premix, alkyl naphthalene sulfonate wetting agent, sodium sulfate, and remaining kaolin are added to a mixing device and mixed evenly. Water is then slowly added and kneaded. The amount of water added is controlled so that the material can be extruded into strips without significant sticking. After extrusion granulation, the mixture is dried at a temperature not exceeding 45°C. Excessive coarse particles and fine powder are sieved out to obtain water-dispersible granules containing 30% quinoline copper and 8% jinggangmycin.

[0045] When the formulation is added to water, soluble starch and sodium sulfate absorb water and promote particle disintegration. Alkyl naphthalene sulfonate is used to shorten the particle wetting time, while polycarboxylate dispersant and sodium lignosulfonate are used to maintain the dispersion state of the quinoline copper particles after disintegration.

[0046] Example 4

[0047] The composition of the wettable powder in this embodiment is shown in Table 4.

[0048] Table 4. Components and content of the wettable powder in Example 4 Quinoline copper 30.00% Jinggangmycin 8.00% polycarboxylate dispersants 3.00% Sodium lignosulfonate 4.00% Polyvinylpyrrolidone K30 1.00% Trehalose 4.00% Sodium dodecyl sulfate 1.50% precipitate 8.00% diatomite 10.00% Kaolin 30.50% total 100.00%

[0049] First, quinoline copper is mixed with polycarboxylate dispersant, sodium lignosulfonate, silica and some kaolin and then pulverized to obtain quinoline copper premix powder. Separately, jinggangmycin, polyvinylpyrrolidone K30, trehalose and diatomaceous earth are mixed to obtain jinggangmycin premix powder.

[0050] The two premixed powders were put into a mixing device, and sodium dodecyl sulfate and the remaining kaolin were added. The mixture was mixed evenly under the condition of avoiding a significant increase in material temperature. After sieving, a wettable powder containing 30% quinoline copper and 8% jinggangmycin was obtained.

[0051] Silica is used for adsorption and to improve the flowability of the powder; diatomaceous earth is used to support jinggangmycin and its protective components; and sodium dodecyl sulfate is used to improve the wetting of the powder after it is added to water. The two active ingredients are pre-mixed into powders separately before being mixed, which helps to reduce uneven local component content and powder agglomeration.

[0052] Example 5

[0053] To investigate the compatibility of the two active ingredients at different mass ratios, the compounding ratios listed in Table 5 were set up while maintaining the total content of active ingredients at 38%. Each ratio group could use the suspending agent system of Example 1, where the mass difference caused by variations in the amount of active ingredients was made up with deionized water.

[0054] Table 5. Ratio of Quinoline Copper to Jinggangmycin Compound Group 1 25.33% 12.67% 2∶1 Compound Group 2 28.50% 9.50% 3∶1 Compound Group 3 30.00% 8.00% 15∶4 Compound group 4 31.67% 6.33% 5∶1 Compound group 5 33.78% 4.22% 8∶1

[0055] In each compound group, the quinoline copper was first wetted and ground according to the method in Example 1. Jinggangmycin was mixed with the protective colloid and sugar protectant and then added to the quinoline copper dispersion. Compound group 3 corresponds to the main formulation composition of the present invention.

[0056] Comparative Example 1

[0057] Based on Example 1, polyvinylpyrrolidone K30 and trehalose were removed, and the reduction of 2.60% was made up by deionized water. The content of the remaining components and the preparation conditions were the same as in Example 1.

[0058] This comparative example is used to compare the effects of protective colloids and sugar-based preservatives on the retention of jinggangmycin content, formulation appearance, and changes in state before and after heat storage.

[0059] Comparative Example 2

[0060] Comparative Example 2 was based on Example 1, except that sodium lignosulfonate was removed, the content of polycarboxylate dispersant was adjusted to 4.00%, and the content of other components and preparation conditions were the same as in Example 1.

[0061] This comparative example is used to compare the suspension rate, particle size change, and redispersion state of quinoline copper particles when polycarboxylate dispersants are used alone or in combination with polycarboxylate dispersants and lignin sulfonate dispersants.

[0062] Comparative Example 3

[0063] Comparative Example 3 was based on Example 1, except that magnesium aluminum silicate and xanthan gum were removed, and the reduction of 0.68% was made up by deionized water. The content of the remaining components and the preparation conditions were the same as in Example 1.

[0064] This comparative example is used to compare the effects of mineral stabilizers and xanthan gum-formed suspension stabilization networks on formulation sedimentation, bottom agglomeration, and flow characteristics.

[0065] Experimental Example 1

[0066] The suspensions prepared in Examples 1, 2 and Comparative Examples 1 to 3 were used as test samples. The D90 of quinoline copper particles, suspension rate, retention rate of jinggangmycin active ingredients and redispersibility of the samples were tested after being stored at 54℃±2℃ for 14 days.

[0067] The contents of quinoline copper and jinggangmycin were determined by high performance liquid chromatography, and the particle size was determined by laser particle size analyzer. The suspension rate was calculated by measuring the quinoline copper content in the upper suspension after dilution with standard hard water and standing. The redispersibility was evaluated by the number of inversions required for the sample to return to a homogeneous state and the bottom sedimentation state. The results are shown in Table 6.

[0068] Table 6 Results of the test on the thermal stability of the suspension. Example 1 3.8 94.6 97.4 Inverted 5 times to restore uniformity, no hard deposits. Example 2 4.2 92.1 95.9 Inverted 7 times to restore uniformity, no hard deposits. Comparative Example 1 4.9 87.3 89.8 Inverted 13 times to restore uniformity, with a small amount of soft deposits. Comparative Example 2 5.6 84.5 94.3 Inverting the container 16 times restores uniformity, but the bottom sedimentation is more noticeable. Comparative Example 3 6.4 76.8 94.9 The inverted structure did not fully recover, and hard deposits remain.

[0069] As shown in Table 6, the D90 of the quinoline copper particles after heat storage in Examples 1 and 2 was lower than that of the respective comparative proportions, the suspension rate remained above 92%, the retention rate of jinggangmycin was not less than 95.9%, and the samples could be restored to uniformity after a few inversions.

[0070] Comparative Example 1, without the addition of protective colloids and sugar-based protective agents, showed a significant decrease in the retention rate of jinggangmycin; Comparative Example 2, using only polycarboxylate dispersants, showed significant changes in particle size and suspension rate after heat storage; Comparative Example 3, after removing magnesium aluminum silicate and xanthan gum, formed a difficult-to-disperse deposit at the bottom of the sample.

[0071] The results showed that the synergistic effect of the composite dispersant, protective colloid, sugar protectant, and suspension stabilizer was beneficial to maintaining the dispersion and redispersion state of the formulation after heat storage.

[0072] Experimental Example 2

[0073] Using rice sheath blight pathogen as the test pathogen, single-agent treatments of quinoline copper, single-agent treatment of jinggangmycin, and compound treatments of quinoline copper to jinggangmycin at mass ratios of 2:1, 3:1, 15:4, 5:1 and 8:1 were set up.

[0074] Five concentration gradients of each test reagent were prepared and added to the culture medium to make drug-containing plates. Mycelial cakes of the same diameter were inoculated in the center of the plates. Each concentration was replicated three times. After incubation, the colony diameter was measured, the mycelial growth inhibition rate and the half-maximal effective concentration (EC50) were calculated, and the co-toxicity coefficient was calculated using the Sun Yunpei method.

[0075] A co-toxicity coefficient greater than 120 was determined to be an synergistic effect, 80-120 was determined to be an additive effect, and less than 80 was determined to be an antagonistic effect. The test results are shown in Table 7.

[0076] Table 7. Results of indoor toxicity assays against *Rhizoctonia solani* at different compound ratios. Quinoline copper — 31.8 — Jinggangmycin — 8.6 — Quinoline copper + Jinggangmycin 2∶1 17.2 97.3 Quinoline copper + Jinggangmycin 3∶1 14.8 128.3 Quinoline copper + Jinggangmycin 15∶4 14.3 141.8 Quinoline copper + Jinggangmycin 5∶1 16.4 133.8 Quinoline copper + Jinggangmycin 8∶1 20.6 118.8

[0077] As shown in Table 7, the co-toxicity coefficients of quinoline copper to jinggangmycin at mass ratios of 3:1, 15:4, and 5:1 were all greater than 120; among them, the EC50 of the compound treatment with a mass ratio of 15:4 was 14.3 mg / L, and the co-toxicity coefficient was 141.8. Under the experimental conditions, the ratio of the effective components of 30% quinoline copper to 8% jinggangmycin showed a synergistic effect against rice sheath blight pathogens.

[0078] Experimental Example 3

[0079] Experiments were conducted in fields where rice sheath blight and bacterial leaf streak were relatively evenly distributed. Examples included: suspension concentrate, quinoline copper monotherapy, jinggangmycin monotherapy, two monotherapy treatments mixed together, and a water control.

[0080] Each treatment was arranged in a randomized block design with four replicates. The first application was performed at the early stage of disease occurrence, and the second application was performed 8 days later. The control effect on rice sheath blight was investigated at 7, 14 and 21 days after the second application, and the control effect on bacterial leaf streak was investigated at 14 days after the application. At the same time, the presence of visible phytotoxicity in rice plants was observed. The results are shown in Table 8.

[0081] Table 8 Field control results of different pesticide treatments Example 1: Suspension 380 83.4 87.1 82.6 84.5 none Quinoline copper single dose 300 58.9 61.7 53.8 82.1 none Jinggangmycin single dose 80 72.5 76.8 69.3 18.6 none Two single-agent mixtures 380 80.6 83.2 77.4 83.4 none Water comparison — — — — — none

[0082] As shown in Table 8, the control efficacy of the suspension concentrate in Example 1 against rice sheath blight was 87.1% 14 days after application, and remained at 82.6% 21 days after application. Under the same active ingredient dosage, its control efficacy at each investigation time was higher than that of the two single-agent mixed treatments. The control efficacy of the suspension concentrate in Example 1 against bacterial leaf streak was 84.5% 14 days after application, similar to that of quinoline copper single agent and the two single-agent mixed treatments.

[0083] During the experiment, no leaf chlorosis, spotting, curling, or inhibited plant growth was observed in any of the pesticide treatments. These results indicate that the formulation can be used simultaneously to control rice sheath blight and bacterial leaf streak, and can maintain relatively stable field control efficacy.

[0084] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any person skilled in the art can easily conceive of various variations or substitutions within the technical scope disclosed in the present invention, and these should all be included within the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be determined by the scope of the claims.

Claims

1. A pesticide composition containing quinoline copper and jinggangmycin, characterized in that, The active ingredient of the pesticide composition consists of quinoline copper and jinggangmycin, wherein the mass ratio of quinoline copper to jinggangmycin is 2:1 to 8:

1.

2. The pesticide composition containing quinoline copper and jinggangmycin according to claim 1, characterized in that, The mass ratio of quinoline copper to jinggangmycin is 3:1 to 5:

1.

3. The pesticide composition containing quinoline copper and jinggangmycin according to claim 2, characterized in that, The mass ratio of quinoline copper to jinggangmycin is 15:

4.

4. A pesticide formulation containing quinoline copper and jinggangmycin, characterized in that, The pesticide formulation comprises, by total mass, 20%–70% active ingredient, 1.0%–5.0% polycarboxylate dispersant, 0.5%–4.0% lignin sulfonate dispersant, 0.2%–2.0% protective colloid, 0.5%–5.0% sugar protectant, 0.1%–10.0% mineral stabilizer, and the remainder being formulation excipients and carrier; the active ingredient is composed of quinoline copper and jinggangmycin, wherein the mass ratio of quinoline copper to jinggangmycin is 3:1 to 5:1; the pesticide formulation is a suspension concentrate, water-dispersible granules, or wettable powder.

5. The pesticide formulation containing quinoline copper and jinggangmycin according to claim 4, characterized in that, Based on the total mass of the pesticide formulation, the quinoline copper content is 30%, the jinggangmycin content is 8%, and the total mass percentage of the active ingredient is 38%.

6. The pesticide formulation containing quinoline copper and jinggangmycin according to claim 5, characterized in that, The pesticide formulation is a suspension concentrate, which, by total mass, further comprises 1.5%–3.5% polycarboxylate dispersant, 1.0%–2.5% lignin sulfonate dispersant, 0.3%–1.2% alkyl glycoside wetting agent, 0.3%–1.0% polyvinylpyrrolidone, 1.0%–3.0% trehalose, 3.0%–6.0% propylene glycol, 0.3%–0.8% magnesium aluminum silicate, 0.1%–0.3% xanthan gum, 0.1%–0.5% buffering agent, 0.05%–0.3% preservative, 0.05%–0.3% defoamer, and the balance being water.

7. The pesticide formulation containing quinoline copper and jinggangmycin according to claim 6, characterized in that, When the cumulative volume distribution of quinoline copper particles in the suspension reaches 90%, the corresponding particle size D90 is 2μm to 6μm, and the pH value of the suspension is 6.2 to 6.

8.

8. The pesticide formulation containing quinoline copper and jinggangmycin according to claim 5, characterized in that, The pesticide formulation is a water-dispersible granule, and by total mass of the water-dispersible granule, it further includes 3%–5% polycarboxylate dispersant, 2%–4% lignin sulfonate dispersant, 0.5%–1.5% polyvinylpyrrolidone, 3%–5% trehalose, 1%–3% alkylnaphthalene sulfonate wetting agent, 8%–12% soluble starch, 6%–10% sodium sulfate, 0.5%–2.0% silica, and the balance being kaolin.

9. The pesticide formulation containing quinoline copper and jinggangmycin according to claim 5, characterized in that, The pesticide formulation is a wettable powder, and by total mass of the wettable powder, it further includes 2%–4% polycarboxylate dispersant, 3%–5% lignin sulfonate dispersant, 0.5%–1.5% polyvinylpyrrolidone, 3%–5% trehalose, 1%–2% sodium dodecyl sulfate, 6%–10% silica, 8%–12% diatomaceous earth, and the balance being kaolin.

10. The pesticide formulation containing quinoline copper and jinggangmycin according to claim 6, characterized in that, Based on the total mass of the suspension, it comprises 30.00% quinoline copper, 8.00% jinggangmycin, 2.40% polycarboxylate dispersant, 1.60% sodium lignosulfonate, 0.80% alkyl glycoside wetting agent, 0.60% polyvinylpyrrolidone, 2.00% trehalose, 4.00% propylene glycol, 0.50% magnesium aluminum silicate, 0.18% xanthan gum, 0.25% buffer conditioner composed of acetic acid and sodium acetate, 0.15% sodium benzoate, 0.20% organosilicon defoamer, and 49.32% deionized water.