A composition of mesoform suitable for mixing with a pesticide formulation

Abstract

The present application provides a kind of suitable for mixing with pesticide preparation mesngmycin composition, it includes active ingredient and adjuvant, the active ingredient is mesngmycin, the adjuvant includes one or more of wetting agent, synergist, dispersing agent.The mesngmycin composition of the present application is mixed with other types of pesticide composition and used, does not produce flocculation, precipitation, drug stability and use efficacy etc.are significantly improved.

Description

Technical Field

[0001] This invention belongs to the field of pesticide technology, specifically relating to a streptomycin composition suitable for mixing with pesticide formulations and its application. Background Technology

[0002] Zhongshengmycin, also known as Nongkang 751 or Streptomycin, is an N-glycoside antibiotic developed by the Institute of Biological Control, Chinese Academy of Agricultural Sciences. It is a novel agricultural antibiotic produced by the Hainan variant of *Streptomyces lilacinus*. Zhongshengmycin has a broad antibacterial spectrum, effective against Gram-positive bacteria, Gram-negative bacteria, mycobacteria, yeasts, and filamentous fungi, and also has some insecticidal activity. In agriculture, it is primarily used to control bacterial diseases such as rice bacterial blight, cucumber bacterial angular leaf spot, cabbage soft rot, and bacillary canker. It can also be used to control fungal diseases such as apple ring rot, cucumber downy mildew, gray mold, powdery mildew, and tomato late blight. It has a particularly significant inhibitory effect on pathogenic fungi of crops such as *Streptomyces cerevisiae*, *Streptomyces cucumeroides*, *Streptomyces oryzae*, *Streptomyces fusilli*, and *Streptomyces fulva*. Currently, there are 49 pesticide registration certificates for kasugamycin in China, including 1 technical grade, 23 single-agent formulations, and 25 compound formulations. The formulations are mainly concentrated in wettable powder, soluble concentrate, granules, and soluble powder.

[0003] In agricultural production, the problem of mixed occurrence of different types of diseases often arises. Farmers typically mix multiple products with different efficacies for simultaneous spraying, essentially "mixing" various formulations and active ingredients. However, the inventors of this application have discovered that mixing existing kasugamycin products with various types of pesticides often results in flocculation and precipitation, which can severely clog spray nozzles, making pesticide application difficult. More importantly, flocculation and precipitation reduce the stability of the pesticide and decrease its efficacy, thus hindering the widespread application of kasugamycin products in agriculture. Summary of the Invention

[0004] To overcome the shortcomings of existing technologies, this invention provides a kasugamycin composition suitable for mixing with pesticide formulations. When the kasugamycin composition of this invention is mixed with other types of pesticides, it does not produce flocculation or precipitation, and the stability and actual efficacy of the drug are significantly improved.

[0005] In a first aspect, the present invention provides a streptomycin composition suitable for mixing pesticide formulations, characterized in that it comprises an active ingredient and adjuvants, wherein the active ingredient is streptomycin, and the adjuvants include one or more of wetting agents, synergists, and dispersants; preferably, the adjuvants further include penetrants.

[0006] Furthermore, the synergist is selected from one or more of alkyl sulfonates, alkyl sulfates, and alkyl ether sulfates; Preferably, the synergist is selected from one or more of sodium ethoxylated alkyl sulfate, sodium fatty alcohol polyoxyethylene ether sulfate, alkyl ethyl sulfonate, and sodium lauryl ether sulfate.

[0007] Preferably, the penetrant is selected from one or more of polyethers, polyoxyethylene ethers, and fatty acid esters; Preferably, the polyoxyethylene ethers include one or more of castor oil polyoxyethylene ethers, fatty alcohol polyoxyethylene ethers, alkylphenol polyoxyethylene ethers, isomeric alcohol polyoxyethylene ethers, and alkyl glycosides; More preferably, the penetrant is selected from one or more of EOPO block polyether, hydroxyl polyethylene oxide block copolymer, polyether segment semi-branched ethoxylate, castor oil polyoxyethylene ether, fatty alcohol polyoxyethylene ether, octylphenol polyoxyethylene ether, nonylphenol polyoxyethylene ether, octylphenol polyoxyethylene ether, polyethylene glycol p-isooctylphenyl ether, Span, Tween, isodecyl alcohol polyoxyethylene ether, isodecyl alcohol polyether, and alkyl glycosides.

[0008] Further, the dispersant is selected from high molecular weight carboxylate polymers and / or polyoxyethylene ether phosphates; preferably, the polyoxyethylene ether phosphates include one or more of fatty alcohol ether polyoxyethylene ether phosphates, isomeric alcohol ether polyoxyethylene ether phosphates, alkylphenol polyoxyethylene ether phosphates, and arylphenol polyoxyethylene ether phosphates. More preferably, the dispersant is selected from one or more of the following: sodium polycarboxylate, ammonium polycarboxylate, potassium polycarboxylate, lauryl alcohol polyoxyethylene ether phosphate, octyl alcohol polyoxyethylene ether phosphate, isooctyl alcohol polyoxyethylene ether phosphate, nonylphenol polyoxyethylene ether phosphate, octylphenol polyoxyethylene ether phosphate, phenol polyoxyethylene ether phosphate, and tristyrene-phenol polyoxyethylene ether phosphate. Further, the wetting agent is an alkyl sulfonate and / or a phosphate ester and its salt; preferably, the phosphate ester and its salt are selected from one or more of fatty alcohol ether phosphate esters, phenolic ether phosphate esters, isomeric alcohol phosphate esters, alkyl phosphate esters, potassium salts of fatty alcohol ether phosphate esters, potassium salts of phenolic ether phosphate esters, potassium salts of isomeric alcohol ether phosphate esters, and potassium salts of alkyl phosphate esters. More preferably, the wetting agent is selected from one or more of the following: sodium dioctyl succinate, sodium diisooctyl maleate sulfonate, calcium dodecylbenzene sulfonate, ammonium dodecylbenzene sulfonate, potassium dodecylbenzene sulfonate, sodium dodecylbenzene sulfonate, isooctanol phosphate, potassium isooctanol phosphate, isotrimethylene ether phosphate, potassium isotridecyl ether phosphate, lauryl phosphate, potassium lauryl phosphate, fatty alcohol ether phosphate, potassium fatty alcohol ether phosphate, phenolic ether phosphate, and potassium phenolic ether phosphate. In this invention, the superordinate concepts such as fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, high molecular weight carboxylate polymer, isomeric alcohol polyoxyethylene ether, fatty alcohol ether phosphate, phenolic ether phosphate, alkylphenol polyoxyethylene ether phosphate, alkyl phosphate, fatty alcohol ether phosphate potassium salt, phenolic ether phosphate potassium salt, isomeric alcohol ether phosphate potassium salt, and alkyl phosphate potassium salt can refer to specific products sold in the market, or a class of products with similar structures and functions.

[0009] Furthermore, the streptomycin composition further includes an antifreeze agent. Preferably, the antifreeze agent is selected from one or more of ethylene glycol, propylene glycol, glycerol, propylene glycol methyl ether, ethylene glycol butyl ether, propylene glycol butyl ether, diethylene glycol dibutyl ether, ethylene glycol phenyl ether, and propylene glycol phenyl ether.

[0010] In some embodiments of the present invention, the adjuvants in the kasugamycin composition include a wetting agent, a synergist, and a dispersant; further, the mass ratio of the wetting agent, synergist, and dispersant is (1-10):(1-10):(1-10); the mass ratio of each component in the kasugamycin composition of the present invention can be a ratio formed by any point value selected from the numerical range described above; preferably, the mass ratio of the wetting agent, synergist, and dispersant is (1-5):(1-5):(1-5), or a ratio formed by any point value selected from the numerical range described above. The ratio of the three components can be any value from wetting agent 1-10 (e.g., 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 2.4, 2.6, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, etc.) to any value from synergist 1-10 (e.g., 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9). The ratio formed by (e.g., 2, 2.4, 2.6, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, etc.) and any point value among dispersants 1-10, such as 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 2.4, 2.6, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, etc.).

[0011] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, and dispersant is 6:7:4.

[0012] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, and dispersant is 3:8:4.

[0013] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, and dispersant is 2:4:5.

[0014] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, and dispersant is 5:6:6.

[0015] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, and dispersant is 7:6:8.

[0016] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, and dispersant is 6:3:1.

[0017] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, and dispersant is 2:9:7.

[0018] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, and dispersant is 8:2:7.

[0019] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, and dispersant is 5:2:9.

[0020] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, and dispersant is 6:9:8.

[0021] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, and dispersant is 5:4:8.

[0022] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, and dispersant is 6:4:10.

[0023] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, and dispersant is 3:6:8.

[0024] Furthermore, the adjuvants in the kasugamycin composition include wetting agents, synergists, penetrants, and dispersants, and the mass ratio of the wetting agents, synergists, penetrants, and dispersants is (1-10):(1-10):(1-10):(1-10).

[0025] Furthermore, in the kasugamycin composition described in this invention, the mass ratio of each component can be any value selected from the numerical range mentioned above. For example, if the mass ratio of wetting agent, synergist, penetrant, and dispersant is (1-10):(1-10):(1-10):(1-10), then the ratio of the four components can be any value from 1 to 10 for the wetting agent (e.g., 1, 1.1, 1.2, 1.3). The values ​​1, 4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 2.4, 2.6, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, etc.) are compared with any point value in synergists 1-10 (e.g., 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 2). Values ​​4, 2.6, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, etc., and any point value among penetrants 1-10 (e.g., 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 2.4, 2.6, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5). The ratio formed by the values ​​of dispersants 1-10 (e.g., 1, 7, 7.5, 8, 8.5, 9, 9.5, 10, etc.) to any point value among dispersants 1-10, such as 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 2.4, 2.6, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, etc.).

[0026] Preferably, the mass ratio of the wetting agent, synergist, penetrant and dispersant is (1-5):(1-5):(1-5):(1-5).

[0027] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, penetrant, and dispersant is 5:5:2:4.

[0028] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, penetrant, and dispersant is 7:10:6:9.

[0029] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, penetrant, and dispersant is 2:8:7:8.

[0030] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, penetrant, and dispersant is 10:3:8:3.

[0031] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, penetrant, and dispersant is 5:7:10:7.

[0032] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, penetrant, and dispersant is 2:10:10:5.

[0033] Furthermore, the streptomycin composition also includes an antifoaming agent and a preservative.

[0034] In some embodiments of the present invention, the defoamer is one or more of polyether-modified organosilicon, organosiloxane, organosilicone, modified organosilane, and organosilicon; the preservative is one or more of Kathon, sodium benzoate, isothiazolinone, benzisothiazolinone, sodium methylparaben, and ethylparaben.

[0035] In some embodiments of the present invention, the pesticide formulation is a suspension concentrate or a water-dispersible granule.

[0036] In some embodiments of the present invention, the streptomycin composition suitable for mixing with pesticide formulations is an aqueous solution (AS), a soluble concentrate (SL), a powder (DP), a wettable powder (WP), a soluble powder (SP), a suspension concentrate (SC), a water-dispersible granule (WG), a pellet (GR), or a soluble granule (SG).

[0037] In some embodiments of the present invention, the streptomycin composition further includes a tank mixing adjuvant.

[0038] Preferably, the tank mixing additive is selected from alkyl sulfonates and / or phosphate esters and their salts; preferably, the phosphate esters and their salts are selected from one or more of fatty alcohol ether phosphate esters, phenolic ether phosphate esters, isomeric alcohol phosphate esters, alkyl phosphate esters, potassium salts of fatty alcohol ether phosphate esters, potassium salts of phenolic ether phosphate esters, potassium salts of isomeric alcohol ether phosphate esters, and potassium salts of alkyl phosphate esters; more preferably, the tank mixing additive is selected from one or more of sodium dioctyl succinate, sodium diisooctyl maleate sulfonate, calcium dodecylbenzene sulfonate, ammonium dodecylbenzene sulfonate, potassium dodecylbenzene sulfonate, sodium dodecylbenzene sulfonate, isooctanol phosphate ester, potassium isooctanol phosphate ester, isotrimethylene ether phosphate ester, potassium isotridecyl ether phosphate ester, lauryl phosphate ester, potassium lauryl phosphate ester, fatty alcohol ether phosphate ester, potassium fatty alcohol ether phosphate ester, phenolic ether phosphate ester, and potassium phenolic ether phosphate ester; Preferably, the mass ratio of the mixing agent to the wetting agent is 5-20:1. Further, the mass ratio of the mixing agent to the wetting agent can be any value selected from the numerical range described above, such as 5:1, 5.1:1, 5.2:1, 5.3:1, 5.4:1, 5.5:1, 5.6:1, 5.7:1, 5.8:1, 5.9:1, 6:1, 6.5:1, 7:1, 7.5:1, 8:1, 8.5:1, 9:1, etc. 1, 9.5:1, 10:1, 10.5:1, 11:1, 11.5:1, 12:1, 12.5:1, 13:1, 13.5:1, 14:1, 14.5:1, 15:1, 15.5:1, 16:1, 16.5:1, 17:1, 17.5:1, 18:1, 18.5:1, 19:1, 19.5:1, 20:1, etc.

[0039] Preferably, the mass ratio of the barrel mixing agent to the wetting agent is 8-18:1; more preferably, the mass ratio of the barrel mixing agent to the wetting agent is 10-15:1.

[0040] A streptomycin composition suitable for aerial application and for mixing with pesticide formulations is characterized by comprising an active ingredient and adjuvants, wherein the active ingredient is streptomycin, and the adjuvants include one or more wetting agents, synergists, and dispersants. Preferably, the adjuvants include wetting agents, synergists, and dispersants.

[0041] A streptomycin composition suitable for aerial application and mixing with pesticide formulations is characterized by comprising an active ingredient and adjuvants, wherein the active ingredient is streptomycin, and the adjuvants include one or more wetting agents, synergists, and dispersants. Preferably, the adjuvants include wetting agents, synergists, and dispersants. The streptomycin composition further includes tank-mixing adjuvants.

[0042] A streptomycin composition suitable for aerial application and for mixing with pesticide formulations is characterized by comprising an active ingredient and adjuvants, wherein the active ingredient is streptomycin, and the adjuvants include one or more of wetting agents, synergists, penetrants, and dispersants. Preferably, the adjuvants include wetting agents, synergists, penetrants, and dispersants.

[0043] A streptomycin composition suitable for aerial application and mixing with pesticide formulations is characterized by comprising an active ingredient and adjuvants, wherein the active ingredient is streptomycin, and the adjuvants include one or more of wetting agents, synergists, penetrants, and dispersants. Preferably, the adjuvants include wetting agents, synergists, penetrants, and dispersants. The streptomycin composition further includes tank-mixing adjuvants.

[0044] A second aspect of the present invention provides an adjuvant composition suitable for mixing with kasugamycin, characterized in that it comprises one or more of a wetting agent, a synergist, and a dispersant; preferably, the adjuvant further comprises a penetrant.

[0045] Furthermore, the synergist is selected from one or more of alkyl sulfonates, alkyl sulfates, and alkyl ether sulfates; Preferably, the synergist is selected from one or more of sodium ethoxylated alkyl sulfate, sodium fatty alcohol polyoxyethylene ether sulfate, alkyl ethyl sulfonate, and sodium lauryl ether sulfate.

[0046] Preferably, the penetrant is selected from one or more of polyethers, polyoxyethylene ethers, and fatty acid esters; Preferably, the polyoxyethylene ethers include one or more of castor oil polyoxyethylene ether, fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, isomeric alcohol polyoxyethylene ether, and alkyl glycosides; More preferably, the penetrant is selected from one or more of EOPO block polyether, hydroxyl polyethylene oxide block copolymer, polyether segment semi-branched ethoxylate, castor oil polyoxyethylene ether, fatty alcohol polyoxyethylene ether, octylphenol polyoxyethylene ether, nonylphenol polyoxyethylene ether, octylphenol polyoxyethylene ether, polyethylene glycol p-isooctylphenyl ether, Span, Tween, isodecyl alcohol polyoxyethylene ether, isodecyl alcohol polyether, and alkyl glycosides.

[0047] Further, the dispersant is selected from high molecular weight carboxylate polymers and / or polyoxyethylene ether phosphates; preferably, the polyoxyethylene ether phosphates include one or more of fatty alcohol ether polyoxyethylene ether phosphates, isomeric alcohol ether polyoxyethylene ether phosphates, alkylphenol polyoxyethylene ether phosphates, and arylphenol polyoxyethylene ether phosphates. More preferably, the dispersant is selected from one or more of the following: sodium polycarboxylate, ammonium polycarboxylate, potassium polycarboxylate, lauryl alcohol polyoxyethylene ether phosphate, octyl alcohol polyoxyethylene ether phosphate, isooctyl alcohol polyoxyethylene ether phosphate, nonylphenol polyoxyethylene ether phosphate, octylphenol polyoxyethylene ether phosphate, phenol polyoxyethylene ether phosphate, and tristyrene-phenol polyoxyethylene ether phosphate. Further, the wetting agent is an alkyl sulfonate and / or a phosphate ester and its salt; preferably, the phosphate ester and its salt are selected from one or more of fatty alcohol ether phosphate esters, phenolic ether phosphate esters, isomeric alcohol phosphate esters, alkyl phosphate esters, potassium salts of fatty alcohol ether phosphate esters, potassium salts of phenolic ether phosphate esters, potassium salts of isomeric alcohol ether phosphate esters, and potassium salts of alkyl phosphate esters. More preferably, the wetting agent is selected from one or more of the following: sodium dioctyl succinate, sodium diisooctyl maleate sulfonate, calcium dodecylbenzene sulfonate, ammonium dodecylbenzene sulfonate, potassium dodecylbenzene sulfonate, sodium dodecylbenzene sulfonate, isooctanol phosphate, potassium isooctanol phosphate, isotrimethylene ether phosphate, potassium isotridecyl ether phosphate, lauryl phosphate, potassium lauryl phosphate, fatty alcohol ether phosphate, potassium fatty alcohol ether phosphate, phenolic ether phosphate, and potassium phenolic ether phosphate. In this invention, the superordinate concepts such as fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether, high molecular weight carboxylate polymer, isomeric alcohol polyoxyethylene ether, fatty alcohol ether phosphate, phenolic ether phosphate, alkylphenol polyoxyethylene ether phosphate, alkyl phosphate, fatty alcohol ether phosphate potassium salt, phenolic ether phosphate potassium salt, isomeric alcohol ether phosphate potassium salt, and alkyl phosphate potassium salt can be specific products or a class of products with similar structures and functions.

[0048] In some embodiments of the present invention, the adjuvant composition includes a wetting agent, a synergist, and a dispersant; further, the mass ratio of the wetting agent, synergist, and dispersant is (1-10):(1-10):(1-10), or a ratio formed by any point value selected from the above numerical range, for example, the mass ratio of the wetting agent, synergist, and dispersant is (1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 2.4, 2.6, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, or 10):(1, 1.1, 1.5). 2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 2.4, 2.6, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, or 10): (1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 2.4, 2.6, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, or 10); preferably, the mass ratio of the wetting agent, synergist, and dispersant is (1-5):(1-5):(1-5).

[0049] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, and dispersant is 6:7:4.

[0050] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, and dispersant is 3:8:4.

[0051] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, and dispersant is 2:4:5.

[0052] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, and dispersant is 5:6:6.

[0053] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, and dispersant is 7:6:8.

[0054] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, and dispersant is 6:3:1.

[0055] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, and dispersant is 2:9:7.

[0056] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, and dispersant is 8:2:7.

[0057] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, and dispersant is 5:2:9.

[0058] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, and dispersant is 6:9:8.

[0059] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, and dispersant is 5:4:8.

[0060] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, and dispersant is 6:4:10.

[0061] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, and dispersant is 3:6:8.

[0062] In some specific embodiments of the present invention, the adjuvant composition includes a wetting agent, a synergist, a penetrant, and a dispersant, wherein the mass ratio of the wetting agent, synergist, penetrant, and dispersant is (1-10):(1-10):(1-10):(1-10).

[0063] In the adjuvant composition of the present invention, the mass ratio of each component can be any value selected from the numerical range described above. For example, the mass ratio of wetting agent, synergist, penetrant, and dispersant is (1-10):(1-10):(1-10):(1-10). Then the ratio of the four components can be any value of wetting agent 1-10 (e.g., 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 2.4, 2.6, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, etc.) and any value of synergist 1-10 (e.g., 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 2.4, 2. The values ​​6, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, etc.) are compared with any point value in penetrant 1-10 (e.g., 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 2.4, 2.6, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7). The ratio formed by the values ​​of 7.5, 8, 8.5, 9, 9.5, 10, etc.) and any point value of dispersant 1-10 (e.g., 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 2.4, 2.6, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, etc.).

[0064] Preferably, the mass ratio of the wetting agent, synergist, penetrant and dispersant is (1-5):(1-5):(1-5):(1-5).

[0065] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, penetrant, and dispersant is 5:5:2:4.

[0066] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, penetrant, and dispersant is 7:10:6:9.

[0067] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, penetrant, and dispersant is 2:8:7:8.

[0068] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, penetrant, and dispersant is 10:3:8:3.

[0069] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, penetrant, and dispersant is 5:7:10:7.

[0070] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, penetrant, and dispersant is 2:10:10:5.

[0071] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, penetrant, and dispersant is 5:4:6:8.

[0072] In some embodiments of the present invention, the mass ratio of the wetting agent, synergist, penetrant, and dispersant is 5:4:5:8.

[0073] In some embodiments of the present invention, the additive composition further includes an antifreeze agent; optionally, the antifreeze agent is selected from one or more of ethylene glycol, propylene glycol, glycerol, propylene glycol methyl ether, ethylene glycol butyl ether, propylene glycol butyl ether, diethylene glycol dibutyl ether, ethylene glycol phenyl ether, and propylene glycol phenyl ether.

[0074] In some embodiments of the present invention, the additive composition further includes an antifoaming agent and a preservative; preferably, the antifoaming agent is one or more of polyether-modified organosilicon, organosiloxane, organosilicone, modified organosilane, and organosilicon; and / or the preservative is one or more of Kathon, sodium benzoate, isothiazolinone, benzisothiazolinone, sodium methylparaben, and ethylparaben.

[0075] An adjuvant composition suitable for aerial application and formulated with kasugamycin, characterized in that it comprises one or more of a wetting agent, a synergist, and a dispersant. Preferably, it comprises a wetting agent, a synergist, and a dispersant.

[0076] An adjuvant composition suitable for aerial application and compounding with kasugamycin, characterized in that it comprises one or more of a wetting agent, a synergist, and a dispersant. Preferably, it comprises a wetting agent, a synergist, and a dispersant. The kasugamycin composition further includes a tank-mixing adjuvant.

[0077] An adjuvant composition suitable for aerial application and for mixing with kasugamycin, characterized in that it comprises one or more of a wetting agent, a synergist, a penetrant, and a dispersant. Preferably, it comprises a wetting agent, a synergist, a penetrant, and a dispersant. The adjuvant composition further comprises a tank-mixing adjuvant.

[0078] A third aspect of the present invention provides a streptomycin composition suitable for mixing with pesticide formulations, characterized in that it comprises an active ingredient and an adjuvant, wherein the active ingredient is streptomycin and the adjuvant includes a cationic surfactant.

[0079] Furthermore, the cationic surfactant is two or more of the following: polyquaternium salt, cocoylpropyl dimethyl betaine, dodecyltrimethylammonium chloride, hexadecyltrimethylammonium chloride, hexadecyltrimethylammonium chloride, hydrogenated tallow dimethyl benzyl ammonium chloride, bispalmitoylcarboxyethylhydroxyethylmethylthiomethyl methyl ester ammonium salt, and polydiallyl dimethyl ammonium chloride.

[0080] Furthermore, the additives also include defoamers and preservatives; preferably, the defoamer is one or more of polyether-modified organosilicon, organosiloxane, organosilicone, modified organosilane, and organosilicon; and / or the preservative is one or more of Kathon, sodium benzoate, isothiazolinone, benzisothiazolinone, sodium methylparaben, and ethylparaben.

[0081] In some embodiments of the present invention, the pesticide formulation is a suspension or water-dispersible granule; and / or the kasugamycin composition suitable for mixing with the pesticide formulation is an aqueous solution (AS), a soluble concentrate (SL), a powder (DP), a wettable powder (WP), a soluble powder (SP), a suspension (SC), a water-dispersible granule (WG), a pellet (GR), or a soluble granule (SG).

[0082] In a fourth aspect, the present invention provides an adjuvant composition suitable for mixing with kasugamycin, characterized in that it comprises two or more of the following: polyquaternium salt, cocoylpropyl dimethyl betaine, dodecyltrimethylammonium chloride, hexadecyltrimethylammonium chloride, hexadecyltrimethylammonium chloride, hydrogenated tallow dimethyl benzyl ammonium chloride, bispalmitoylcarboxyethylhydroxyethylmethyl thiomethyl methyl ester ammonium salt, and polydiallyl dimethyl ammonium chloride.

[0083] Furthermore, the additive composition further includes an antifoaming agent and a preservative; preferably, the antifoaming agent is one or more of polyether-modified organosilicon, organosiloxane, organosilicone, modified organosilane, and organosilicon; and / or the preservative is one or more of Kathon, sodium benzoate, isothiazolinone, benzisothiazolinone, sodium methylparaben, and ethylparaben.

[0084] In a fifth aspect, the present invention provides a kasugamycin mixture composition, characterized in that it comprises a first active ingredient and a second active ingredient, wherein the first active ingredient is a kasugamycin composition suitable for mixing with pesticide formulations as described in any of the preceding claims. The present invention also provides a streptomycin mixture composition, characterized in that it comprises a first active ingredient, a second active ingredient, and an adjuvant composition, wherein the first active ingredient is streptomycin, and the adjuvant composition is any of the adjuvant compositions applicable to streptomycin mixtures described above; Preferably, the compounding composition further includes a tank mixing aid selected from alkyl sulfonates and / or phosphate esters and their salts; preferably, the phosphate esters and their salts are selected from one or more of fatty alcohol ether phosphate esters, phenolic ether phosphate esters, isomeric alcohol phosphate esters, alkyl phosphate esters, potassium salts of fatty alcohol ether phosphate esters, potassium salts of phenolic ether phosphate esters, potassium salts of isomeric alcohol ether phosphate esters, and potassium salts of alkyl phosphate esters; more preferably, the tank mixing aid is selected from sodium dioctyl succinate sulfonate and diisooctyl maleate sulfonate. The compound comprises one or more of the following: sodium dodecylbenzenesulfonate, calcium dodecylbenzenesulfonate, ammonium dodecylbenzenesulfonate, potassium dodecylbenzenesulfonate, sodium dodecylbenzenesulfonate, isooctanol phosphate, potassium isooctanol phosphate, isotrimethylene ether phosphate, potassium isotrimethylene ether phosphate, lauryl phosphate, potassium lauryl phosphate, fatty alcohol ether phosphate, potassium fatty alcohol ether phosphate, phenolic ether phosphate, and potassium phenolic ether phosphate; more preferably, the mass ratio of the barrel mixing agent to the wetting agent is 5-15:1. Preferably, the second active ingredient is a pesticide suspension or water-dispersible granule.

[0085] In some embodiments of the present invention, the second active ingredient is one or more of the following: Chuqiu, Glico, Yinfali, Lunason, Shigao, Youbu, Hainuofei, and Nadiwen. Preferably, Chuqiu, Glico, Yinfali, and Lunason are suspension concentrates; Shigao, Youbu, Hainuofei, and Nadiwen are water-dispersible granules. A sixth aspect of the present invention provides a method for preparing the above-mentioned kasugamycin mixture, characterized by comprising the following steps: a. Take a certain amount of the first active ingredient, add water according to the first ratio and stir evenly; then take a certain amount of the second active ingredient, add water according to the second ratio and stir evenly; finally, mix the two diluted solutions and stir evenly to obtain the compound composition; or b. Take a certain amount of the first active ingredient and a certain amount of the second active ingredient, add them sequentially to water according to the third ratio, and stir evenly to obtain the mixture; The first ratio and the second ratio can be the same or different. Preferably, the first ratio is any value between 10 and 300; and / or the first ratio is any value between 10 and 300; and / or the third ratio is any value between 10 and 300; for example, the multiples of the first, second, and third ratios are 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 40, 45, 50, 55, and 6. 0, 65, 70, 75, 80, 85, 90, 95, 100, 105, 110, 115, 120, 125, 130, 135, 140, 145, 150, 155, 160, 165, 170, 175, 180, 185, 190, 195, 200, 205, 210, 215, 220, 225, 230, 235, 240, 245, 250, 255, 260, 265, 270, 275, 280, 285, 290, 295, 300 times, etc.

[0086] Preferably, the first ratio is 10 times, 50 times, 80 times, 100 times, 150 times, 200 times, or 250 times; and / or the second ratio is 10 times, 50 times, 80 times, 100 times, 150 times, 200 times, or 250 times; and / or the third ratio is 10 times, 50 times, 80 times, 100 times, 150 times, 200 times, or 250 times; more preferably, the first ratio is 50 times or 200 times; and / or the second ratio is 50 times or 200 times; and / or the third ratio is 50 times or 200 times.

[0087] In some specific embodiments of the present invention, the first ratio and the second ratio are 50 times; the diluted solution can be used for aerial spraying. In other embodiments, the first ratio and the second ratio are 200 times; the diluted solution can be further used for direct field spraying.

[0088] A seventh aspect of the invention provides the use of the kasugamycin composition or adjuvant composition described in any of the foregoing aspects in the formulation of pesticide preparations.

[0089] The eighth aspect of the present invention provides the application of the streptomycin composition or streptomycin mixture described in any of the foregoing aspects in the prevention and control of plant diseases.

[0090] A ninth aspect of the present invention provides the use of the kasugamycin composition or kasugamycin mixture described in any of the foregoing aspects in the preparation of plant disease control agents.

[0091] In a tenth aspect of the present invention, a method for preventing and controlling plant diseases is provided, characterized in that the plants suffering from plant diseases are treated with the above-mentioned streptomycin composition or a mixture thereof.

Terminology Definition

[0092] The term "technical grade drug" refers to the product obtained during the production process, consisting of the active ingredient and related impurities, with the possible addition of small amounts of additives. The term "parent drug" refers to the product obtained during the production process, consisting of the active ingredient and related impurities, and may contain small amounts of necessary additives and appropriate diluents. For example, kasugamycin parent drug refers to the product obtained during the production process, consisting of kasugamycin and related impurities, and may contain small amounts of necessary additives and appropriate diluents.

[0093] The term "active ingredient" refers to the component in pesticide products that has toxic and killing activity against diseases, insects, and weeds.

[0094] The term "formulation" refers to a stable product made from pesticide technical or parent pesticide and suitable adjuvants, or processed by methods such as bio-fermentation or plant extraction.

[0095] The term "adjuvant" refers to any single or multiple components, other than the active ingredient, added to a pesticide product that do not possess pesticide activity or the function of the active ingredient, but can or help to improve or enhance the physicochemical properties of the pesticide product.

[0096] The term "plant disease" refers to the phenomenon where, during the growth and development of a plant, its growth and development are significantly hindered due to infection by other organisms and adverse abiotic factors. This results in pathological changes both internally and externally, in terms of physiology and tissue structure, leading to illness or even death, and consequently, reduced yield and deteriorated quality. In this application, "plant disease" specifically refers to diseases caused by infection of plants by other organisms, including but not limited to fungi (such as cucumber downy mildew caused by *Pseudomonas columbinis*) or bacteria (such as bacterial angular leaf spot in cucurbits).

[0097] "Wetting agent" refers to a surfactant that can reduce the interfacial tension between solid and liquid or liquid and increase the contact between the liquid and the solid surface or specific liquid surface of the object being treated, so that the liquid can wet or spread on the surface of the target object.

[0098] The term "synergist" refers to a surfactant that enhances the wetting, spreading, and penetrating power of pesticides, expands the control area, and improves resistance to rain washout, thereby improving the effectiveness of pesticide application.

[0099] The term "penetrating agent" refers to an amphiphilic surfactant that does not dissociate into an ionic state in water.

[0100] The term "cationic surfactant" refers to a surfactant that dissociates in aqueous solution to form positively charged ions.

[0101] The term "dispersant" refers to a surfactant that possesses both lipophilic and hydrophilic properties within its molecule. Under external force, it can uniformly disperse solid and liquid particles of inorganic and organic pesticides that are difficult to dissolve in liquids, while also preventing particle sedimentation and aggregation, thus forming a stable suspension or dispersible solid particles.

[0102] The term "surfactant" refers to any compound that is generally considered in the art to possess surface-active properties, capable of significantly reducing the surface tension or interfacial tension between two liquids, between a liquid and a gas, or between a liquid and a solid. Surfactants are generally classified into ionic surfactants (including cationic surfactants, anionic surfactants, and amphoteric surfactants), nonionic surfactants, compound surfactants, and other surfactants.

[0103] The term "antifreeze" is also known as a freeze inhibitor or freeze protectant. It refers to a substance that prevents liquids (such as water) from freezing or forming excessively large ice crystals at low temperatures.

[0104] The term "defoamer," also known as an antifoaming agent, includes defoaming agents, foam suppressants, and defoaming agents. It generally refers to substances with low surface tension, high surface activity, and the ability to inhibit or eliminate foam in liquid systems.

[0105] The term "preservative" refers to natural or synthetic compounds added to food, medicine, pigments, biological specimens, etc., to inhibit spoilage caused by the growth, reproduction, or metabolism of microorganisms, thereby extending the shelf life of the system.

[0106] Compared with the prior art, the present invention has at least the following beneficial effects: (1) The streptomycin composition of the present invention is not prone to flocculation or precipitation when mixed with other types of pesticides, which solves the problem of difficult spraying in the prior art and improves the user experience of farmers. At the same time, the streptomycin composition of the present invention also has good product stability and excellent physicochemical interface properties. Not only is the product stable and easy to store, but it can also increase the wettability of the drug and significantly improve the efficacy.

[0107] (2) The adjuvant composition of the present invention not only solves the problem of difficult mixing of kasugamycin pesticide formulations, but also enhances the stability of kasugamycin formulations, improves the physicochemical interface properties of kasugamycin formulations, and enhances the efficacy.

[0108] (3) The combination of the kasugamycin composition provided by the present invention with other pesticides does not produce flocculation or precipitation, has good product stability and good physicochemical interface properties, and significantly improves the control effect on crop diseases. Attached Figure Description

[0109] The accompanying drawings are provided to further illustrate the invention and form part of the specification. They are used together with the following detailed description to explain the invention, but do not constitute a limitation thereof. In the drawings: Figure 1 The images show the effects of mixing some comparative and example streptomycin compositions with different pesticide formulations at a 200-fold dilution and allowing them to stand for 30 minutes, as part of a mixing effect test. Figure 1 a is a diagram showing the effect of mixing the streptomycin composition of Comparative Example 1 with early autumn. Figure 1 b is a diagram showing the effect of mixing the streptomycin composition of Comparative Example 2 with early autumn. Figure 1 c is a diagram showing the effect of mixing the streptomycin composition of Comparative Example 4 with early autumn. Figure 1 d is a diagram showing the effect of mixing the streptomycin composition of Comparative Example 6 with early autumn. Figure 1 e is an image showing the effect of mixing the streptomycin composition of Example 4 with early autumn. Figure 1 f is a diagram showing the effect of mixing the streptomycin composition of Example 6 with Shigao. Figure 1 g is a diagram showing the effect of mixing the streptomycin composition of Example 8 with Glico. Figure 1 h is a diagram showing the effect of mixing the streptomycin composition of Example 15 with early autumn. Figure 2 This image shows the effects of mixing the streptomycin compositions of some comparative examples and some embodiments with different pesticide formulations in a mixing effect test. Figure 2 a is a diagram showing the effect of mixing the streptomycin composition of Comparative Example 1 with early autumn. Figure 2 b is a diagram showing the effect of mixing the streptomycin composition of Comparative Example 2 with early autumn. Figure 2 c is a diagram showing the effect of mixing the streptomycin composition of Comparative Example 8 with early autumn. Figure 2 d is a diagram showing the effect of mixing the streptomycin composition of Comparative Example 9 with early autumn. Figure 2 e is a diagram showing the effect of mixing the streptomycin composition of Example 21 with early autumn. Figure 2 f is a diagram showing the effect of mixing the streptomycin composition of Example 25 with early autumn. Figure 2g is a diagram showing the effect of mixing the streptomycin composition of Example 27 with Glico; Figure 2 h is a diagram showing the effect of mixing the streptomycin composition of Example 28 with Shigao; Figure 3 This is a comparison diagram of the static surface tension of embodiments and comparative examples of the present invention, wherein... Figure 3 a is a comparison diagram of the static surface tension of water, comparative example 1, comparative example 2, comparative example 4, comparative example 6, example 4, example 6, example 8, and example 15 in this invention; Figure 3 b is a comparison diagram of the static surface tension of water, comparative examples 1, 2, 8, 9, 21, 25, 27, 28, and 29 in this invention; Figure 4 This is a comparison diagram of the contact angles of embodiments and comparative examples of the present invention, wherein... Figure 4 a is a comparison diagram of the contact angles of water, comparative example 1, comparative example 2, comparative example 4, comparative example 6, example 4, example 6, example 8, and example 15 in this invention; Figure 4 b is a comparison diagram of the contact angles of water, comparative examples 1, 2, 8, 9, 21, 25, 27, 28, and 29 in this invention; Figure 5 This is a comparison diagram of contact angles for some embodiments and comparative examples of the present invention; Figure 6 Comparison of thermal storage stability test results of some embodiments and comparative examples of the present invention; Figure 7 The HPLC chromatogram of the kasugamycin composition of Example 4 of the present invention; Figure 8 These are field efficacy diagrams for some embodiments and comparative examples of the present invention. Detailed Implementation

[0110] The present invention will be described below with reference to specific embodiments. It should be noted that the following embodiments are examples of the present invention and are used only to illustrate the invention, not to limit it. Other combinations and various modifications within the scope of the present invention can be made without departing from its spirit or scope.

[0111] All publications, patents and published patent specifications cited in this application are incorporated herein by reference in their entirety.

[0112] Unless otherwise specified, the parts, percentages, or proportions mentioned in the embodiments of this invention are based on mass. Unless otherwise specified, the content of raw materials used in the embodiments of this invention is 100%.

[0113] The numerical range described in this article by the endpoints includes all numerical values ​​contained within that range as well as the endpoint values ​​(for example, 1 to 5 includes 1, 1.5, 2, 2.75, 3, 3.80, 4, 5, etc.).

[0114] [Experimental Materials] Unless otherwise specified, the reagents and solvents used in the following examples are commercially available or prepared by conventional methods known to those skilled in the art. Experimental methods in the following examples that do not specify specific conditions are performed according to conventional methods and conditions.

[0115] The various contents of kasugamycin mother drug, mother liquor, and 3% and 6% kasugamycin soluble concentrate used in the embodiments of the present invention were obtained from Fujian Kaili Biological Products Co., Ltd.

[0116] The pesticide formulations used in the embodiments of this invention can be obtained through the following methods: Corteva Early Autumn (24% cyproconazole suspension concentrate, hereinafter referred to as "Early Autumn") was purchased from Corteva AgroSciences Ltd.; Glico (100g / L bromofenopram suspension concentrate, hereinafter referred to as "Glico") was purchased from BASF Europe; Silver-Fali (a compound suspension concentrate of cymoxanil hydrochloride 625g / L and fluopyram 62.5g / L, hereinafter referred to as "Silver-Fali") was purchased from Bayer AG; Luna Sen (a compound suspension concentrate of fluopyram 21.5% and azoxystrobin 21.5%, hereinafter referred to as "Luna Sen") was purchased from Bayer AG; and Shiga (10% difenoconazole water-dispersible granules, hereinafter referred to as "Shiga") Purchased from Novartis AG, Switzerland; Yubu (a water-dispersible granule of 20% acetamiprid and 60% pymetrozine, hereinafter referred to as "Yubu") was purchased from Shaanxi Thompson Biotechnology Co., Ltd.; Hainuofei (a water-dispersible granule of 25% difenoconazole and 25% azoxystrobin, hereinafter referred to as "Hainuofei") was purchased from Sichuan Hairun Crop Science and Technology Co., Ltd.; Nadiwen (a water-dispersible granule of 50% tebuconazole and 25% azoxystrobin, hereinafter referred to as "Nadiwen") was purchased from Bayer AG; The wetting agents used in the embodiments of this invention can be obtained as follows: sodium dioctyl succinate sulfonate was purchased from Hubei Wande Chemical Co., Ltd.; 70% sodium diisooctyl maleate sulfonate was purchased from Jiangsu Haian Petrochemical Plant; calcium dodecylbenzene sulfonate was purchased from Jiangsu Bosite Chemical Technology Co., Ltd.; ammonium dodecylbenzene sulfonate was purchased from Shanghai Tongyuan Chemical Co., Ltd.; fatty alcohol ether phosphate MOA3P was purchased from Jiangsu Haian Petrochemical Plant; phenolic ether phosphate TXP-10 was purchased from Haian (Linyi) Guoli Chemical Co., Ltd.; and isotretinoin phosphate was purchased from Haian (Linyi) Guoli Chemical Co., Ltd.; Lauryl phosphate MA24P was purchased from Haian (Linyi) Guoli Chemical Co., Ltd.; 70% fatty alcohol ether phosphate potassium salt MOA-3PK-70 was purchased from Jiangsu Haian Petrochemical Plant; 50% phenolic ether phosphate potassium salt NP-4PK was purchased from Jiangsu Haian Petrochemical Plant; 80% isotridecyl ether phosphate potassium salt was purchased from Jiangsu Haian Petrochemical Plant; 50% lauryl phosphate potassium salt MA24PK-50 was purchased from Haian (Linyi) Guoli Chemical Co., Ltd.; Sodium dodecyl sulfate was purchased from Jinan Daorong Chemical Co., Ltd.

[0117] The synergists used in the embodiments of this invention can be obtained as follows: sodium ethoxylated alkyl sulfate was purchased from Jinan Boyang Chemical Co., Ltd.; 70% sodium fatty alcohol polyoxyethylene ether sulfate was purchased from Shandong Tiandao Bioengineering Co., Ltd.; alkyl ethyl sulfonate 280g / L was purchased from Nantong Deyi Chemical Co., Ltd.; 70% sodium lauryl ether sulfate was purchased from Jiangsu Haian Petrochemical Plant; sodium diisobutylnaphthalene sulfonate BX was purchased from Jinan Zhiheng Zhiyuan Chemical Technology Co., Ltd.; and sodium naphthalene sulfonate formaldehyde condensate was purchased from Wuhan Shuer Biotechnology Co., Ltd.

[0118] The penetrants used in the embodiments of this invention can be obtained as follows: EOPO block polyether Ethylan NS-500LQ was purchased from Nanjing Jierun Technology Co., Ltd.; castor oil polyoxyethylene ether EL-80 was purchased from Jiangsu Haian Petrochemical Plant; hydroxyl polyoxyethylene block copolymer was purchased from Xi'an Ruixi Biotechnology; semi-branched C12-13 fatty alcohol ethoxylates (i.e., polyether segment semi-branched ethoxylates) were purchased from Hubei Xinrunde Chemical Co., Ltd.; fatty alcohol polyoxyethylene ether MOA-5 was purchased from Jiangsu Haian Petrochemical Plant; isomeric tridecyl alcohol polyoxyethylene ether was purchased from Jiangsu Haian Petrochemical Plant; octylphenol polyoxyethylene ether OP-15 was purchased from Jiangsu Haian Petrochemical Plant; polyethylene glycol p-isooctylphenyl ether was purchased from Jinan Mingxin Chemical Co., Ltd.; Span 60 was purchased from Jiangsu Haian Petrochemical Plant; Tween 80 was purchased from Jiangsu Haian Petrochemical Plant; isomeric decayl alcohol polyoxyethylene ether was purchased from Jiangsu Haian Petrochemical Plant; alkyl glycosides were purchased from Jiangsu Haolong Chemical Co., Ltd.

[0119] The dispersants used in the embodiments of this invention can be obtained as follows: sodium polycarboxylate SP-2836 was purchased from Jiangsu Qingyu Chemical Technology Co., Ltd.; polycarboxylate T / 36 was purchased from Azeres International Trading (Shanghai) Co., Ltd.; polycarboxylate SP-2836 was purchased from Jiangsu Qingyu Chemical Technology Co., Ltd.; 40% polycarboxylate ammonium salt dispersant was purchased from Weifang Wanhe Chemical Co., Ltd.; phenol polyoxyethylene ether phosphate was purchased from Henan Alpha Chemical Co., Ltd.; lauryl alcohol polyoxyethylene ether phosphate was purchased from Jiangsu Haian Petrochemical Plant; sodium lignosulfonate was purchased from Hubei Xinghengye Technology Co., Ltd.; styrene-phenol polyoxyethylene ether phosphate, phenol polyoxyethylene ether phosphate, lauryl alcohol polyoxyethylene ether phosphate, and nonylphenol polyoxyethylene ether phosphate were purchased from Jiangsu Haian Petrochemical Plant.

[0120] The cationic surfactants used in the embodiments of this invention can be obtained as follows: polyquaternium-28 was purchased from Wuhan Linqing Biotechnology Co., Ltd.; 35% CAPB cocoylpropyl dimethyl betaine was purchased from Qiyuan (Guangdong) Pharmaceutical Chemical Co., Ltd.; 50% dodecyltrimethylammonium chloride was purchased from Shandong Yuquan New Material Technology Co., Ltd.; 50% hexadecyltrimethylammonium chloride was purchased from Wuhan Jiyesheng Chemical Co., Ltd.; 70% hexadecyltrimethylammonium chloride was purchased from Hubei Xinghengye Technology Co., Ltd.; hydrogenated tallow-based dimethyl benzyl ammonium chloride was purchased from Wuhan Haorong Biotechnology Co., Ltd.; 88% bispalmitoylcarboxyethyl hydroxyethyl methyl thiomethyl ester ammonium salt was purchased from Jining Tangyi Chemical Co., Ltd.; polydiallyl dimethyl ammonium chloride was purchased from Jiangsu Youlixin Chemical Co., Ltd.; and cationic modified silicone oil was purchased from Guangzhou Batai Chemical Co., Ltd.

[0121] Other experimental materials, including ethylene glycol, propylene glycol, glycerol, urea, diethylene glycol dibutyl ether, polyether-modified organosilicon B-157, B-554, B-803, organosiloxanes, organosilicones, modified organosilicon AF1501, organosilicon SAG1522 and organosilicon SAG 1572, 10% Kathon, sodium benzoate, isothiazolinone, benzisothiazolinone, and sodium methylparaben, were obtained through ordinary commercial channels. Other materials not specifically mentioned were readily available through general commercial purchase.

[0122]

Preparation Examples

[0123] Preparation method: Mix 60g of 10% kasugamycin mother liquor with deionized water according to the mass percentage in the table above to obtain the above 6% kasugamycin aqueous solution.

[0124] Comparative Example 2 The 6% kasugamycin soluble concentrate uses products from Fujian Kaili Biological Products Co., Ltd.

[0125] Comparative Example 3

[0126] Preparation method: Prepare 6% soluble concentrate of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0127] Comparative Example 4

[0128] Preparation method: Prepare 6% soluble concentrate of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0129] Comparative Example 5

[0130] Preparation method: Prepare 6% soluble concentrate of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0131] Comparative Example 6

[0132] Preparation method: Prepare 6% soluble concentrate of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0133] Example 1

[0134]

[0135] Preparation method: Prepare 6% soluble concentrate of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0136] Example 2

[0137] Preparation method: Prepare 6% soluble concentrate of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0138] Example 3

[0139] Preparation method: According to the formula composition and dosage in the table above, the mother liquor of kasugamycin and the adjuvants are thoroughly mixed and filtered to obtain 1% kasugamycin soluble concentrate.

[0140] Example 4

[0141] Preparation method: According to the formula and dosage in the table above, the mother liquor of kasugamycin and the adjuvants are thoroughly mixed and filtered to obtain 6% kasugamycin soluble concentrate.

[0142] Example 5

[0143] Preparation method: Prepare 6% soluble concentrate of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0144] Example 6

[0145] Preparation method: Prepare 6% soluble concentrate of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0146] Example 7:

[0147] Preparation method: Mix 30% of the biological agent of kasugamycin with the adjuvants according to the composition and dosage in the table above. Add an appropriate amount of light calcium carbonate as filler and polyvinyl alcohol as binder and mix evenly. Then, pulverize the mixture by air jet mill. After pulverizing, the material is mixed by a mixer and extruded into granules. After drying and sieving, the above-mentioned 3% water-dispersible granules are obtained.

[0148] Example 8

[0149] Preparation method: According to the formula and dosage in the table above, the mother liquor of kasugamycin and the adjuvants are thoroughly mixed and filtered to obtain 6% kasugamycin soluble concentrate.

[0150] Example 9

[0151] Preparation method: Prepare 3% soluble solution of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0152] Example 10

[0153] Preparation method: Mix 40% of the biological agent of kasugamycin with the adjuvants according to the formula and dosage in the table above, add an appropriate amount of sodium gluconate as a filler and mix evenly, and then pulverize it with an ultrafine pulverizer to obtain the above 6% soluble granule product.

[0154] Example 11

[0155] Preparation method: Prepare 6% soluble concentrate of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0156] Example 12

[0157] *26% kasugamycin technical material refers to kasugamycin technical material with a kasugamycin mass fraction of 26% in its active ingredient. Preparation method: Mix the kasugamycin mother drug and adjuvants evenly according to the formula and dosage in the table above, and then pulverize them into powder of about 400 mesh by air jet pulverization and mix evenly; add the mixed powder to the extrusion granulator, add an appropriate amount of water for granulation; after granulation, transfer the granules to the dryer and dry them to a moisture content of ≤3% to obtain 7.5% kasugamycin soluble granules.

[0158] Example 13

[0159] Preparation method: Prepare 3% soluble solution of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0160] Example 14

[0161] Preparation method: According to the formula and dosage in the table above, 75% of the biological agent of kasugamycin and the adjuvants are thoroughly mixed and filtered to obtain 6% kasugamycin soluble concentrate.

[0162] Example 15

[0163] Preparation method: Prepare 6% soluble concentrate of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0164] Example 16

[0165] Preparation method: Mix the mother liquor of kasugamycin and the auxiliary agent thoroughly according to the formula composition and dosage in the table above, put it into the reaction vessel and stir for 2 hours, and then grind it in a multi-stage sand mill so that the particle size meets the requirements of the suspension agent to make a 6% suspension agent.

[0166] Example 17

[0167] Preparation method: Prepare 3% soluble solution of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0168] Example 18

[0169] Preparation method: Prepare 6% soluble concentrate of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0170] Comparative Example 7

[0171] Preparation method: Prepare 6% soluble concentrate of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0172] Comparative Example 8

[0173] Preparation method: Prepare 6% soluble concentrate of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0174] Comparative Example 9

[0175] Preparation method: Prepare 6% soluble concentrate of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0176] Example 19

[0177] Preparation method: Prepare 6% soluble concentrate of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0178] Example 20

[0179] Preparation method: Prepare 3% soluble solution of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0180] Example 21

[0181] Preparation method: Prepare 6% soluble concentrate of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0182] Example 22

[0183] Preparation method: Mix the 26% kasugamycin technical material and adjuvants thoroughly according to the formula composition and dosage in the table above, add an appropriate amount of sodium gluconate as filler and mix evenly, then pulverize by an ultrafine pulverizer to obtain the above 6% wettable powder product.

[0184] Example 23

[0185] Preparation method: Prepare 6% aqueous solution of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0186] Example 24

[0187] Preparation method: Prepare 3% soluble solution of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0188] Example 25

[0189] Preparation method: Prepare 6% soluble concentrate of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0190] Example 26

[0191] Preparation method: According to the formula and dosage in the table above, the raw material of kasugamycin and the adjuvants are thoroughly mixed and filtered to obtain 6% kasugamycin soluble concentrate.

[0192] Example 27

[0193] Preparation method: Prepare 6% soluble concentrate of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0194] Example 28

[0195] Preparation method: According to the formula and dosage in the table above, the mother liquor of kasugamycin and the adjuvants are thoroughly mixed and filtered to obtain 6% kasugamycin soluble concentrate.

[0196] Example 29

[0197] Preparation method: Prepare 6% soluble concentrate of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0198] Example 30

[0199] Take 100g of the kasugamycin composition prepared in Example 4 of this invention and add 60g of the tank mixing adjuvant sodium dioctyl succinate sulfonate to prepare a kasugamycin composition for aerial pesticide application.

[0200] Example 31

[0201] Take 100g of the kasugamycin composition prepared in Example 6 of this invention and add 10g of the tank mixing adjuvant lauryl phosphate to prepare a kasugamycin composition for aerial pesticide application.

[0202] In addition, 100g of the kasugamycin composition prepared in Examples 4 and 6 of the present invention can be directly used for aerial pesticide application.

[0203] Example 32

[0204] Preparation method: Prepare 3% soluble solution of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0205] Example 33

[0206] Preparation method: Prepare 6% soluble concentrate of kasugamycin by thoroughly mixing the stock solution of kasugamycin with the adjuvants according to the formula composition and dosage in the table above.

[0207] The kasugamycin compositions prepared in the above preparation examples were all of qualified quality after factory testing. The content of kasugamycin was determined by high performance liquid chromatography, and the content of kasugamycin in each composition met the requirements.

[0208] The specific HPLC determination steps are as follows: The high-performance liquid chromatograph (HPLC) model is: Agilent 1260 Infinity II HPLC system. 1) Chromatographic column: Waters symetryshield RP18, 5 μm particle size, 150 mm × 4.6 mm (id) stainless steel column 2) Reagents: Acetonitrile (chromatographic grade), disodium hydrogen phosphate (analytical grade), sodium heptanesulfonate (analytical grade), phosphoric acid (analytical grade), ultrapure water (self-made). 3) Mobile phase: A: Weigh 4.5 g of sodium heptanesulfonate and 16.25 g of disodium hydrogen phosphate into a 1 L stoppered glass bottle, add 1000 mL of water, adjust the pH to about 2.5 with phosphoric acid, filter through a 0.45 μm filter membrane, sonicate for 15 min, and shake well; B: Acetonitrile (gradient elution) Filter: Membrane pore size approximately 0.45 μm ultrasonic cleaner 4) Detection wavelength: 200 nm 5) Flow rate: 1.0 mL 6) Injection volume: 10 μL in, Figure 7 The image shows the HPLC chromatogram of the kasugamycin composition described in Example 4.

[0209] In addition, those skilled in the art will understand that the adjuvants in the above preparation examples can also be prepared separately, and then mixed with the biological agent or mother liquor of kasugamycin, as well as other commercially available kasugamycin preparations such as 3% or 6% soluble concentrates. Therefore, the adjuvant composition prepared separately also falls within the protection scope of this application.

[0210] [Effectiveness Test Case] I. Mixing Effect Test 1. Mixing test: The mixing test method uses two methods for mixing: The first method (diluted separately and then mixed, diluted 200 times): First, take 100mL of tap water and add 1mL of the septic tank composition, then take another 100mL of tap water and add 1mL (or 1g) of commercially available medicine. Finally, mix the two diluted solutions, stir evenly, and observe the flocculation and precipitation after standing for 30 minutes. The second dilution method (direct mixing dilution, 200 times dilution): Take 200mL of tap water and add 1mL of sclerosin soluble solution and 1mL (or 1g) of commercially available medicine in sequence. Stir well, let stand for 30 minutes, and then observe the flocculation and precipitation.

[0211] Since the flocculation and sedimentation results from the two mixing methods are not significantly different, the mixing method will no longer be distinguished in the mixing experiment results.

[0212] Mixing tests specifically for aerial pesticide application: The first dilution method (dilute separately and then mix, dilute 50 times): First, take 25 mL of tap water and add 1 mL of the streptomycin composition shown in Example 30 or 31. Then, take another 25 mL of tap water and add 1 mL (or 1 g) of commercially available medicine. Finally, mix the two diluents, stir evenly, and observe the flocculation and precipitation after standing for 30 minutes. The second dilution method (direct mixing dilution, 50 times dilution): Take 50 mL of tap water and add 1 mL of the streptomycin composition shown in Example 30 or 31 and 1 mL (or 1 g) of commercially available medicine in sequence. Stir well, let stand for 30 minutes and then observe the flocculation and precipitation.

[0213] Since the two mixing methods are not significantly different, they will not be distinguished in subsequent mixing experiments.

[0214] 1.1 Suspension agent mixing test Comparative Examples 1-9 and Examples 1-33 were respectively mixed with Chuqiu, Glico, Silver Farley, and Lunason.

[0215] 1.2 Water-dispersible granule mixing test Comparative Examples 1-9 and Examples 1-33 were respectively mixed with GE, GE, HYNOF, and NADI.

[0216] 2. Mixture test for flocculation and precipitation detection: The flocculation and precipitation detection method for the mixed sample test was visual inspection. The mixed sample was placed in an Erlenmeyer flask and allowed to stand at room temperature for 30 minutes. The tester then observed the sample through the bottom of the Erlenmeyer flask while it was still standing. To further confirm the flocculation and precipitation status of the sample, a portion of the sample was poured into a sterile petri dish and observed after standing. The flocculation and precipitation of each sample were recorded and photographed using photographic equipment.

[0217] This application classifies flocculation and precipitation according to their severity: no flocculation or precipitation is marked as "-"; slight flocculation or precipitation is marked as "+"; significant flocculation or precipitation is marked as "++"; and severe flocculation or precipitation is marked as "+++".

[0218] 2.1 The precipitation test results of the suspension mixing test are as follows:

[0219] 2.2 The precipitation test results of the water-dispersible granules mixing test are as follows: [List of products - likely related to formulations or formulations]

[0220] Test results: According to the table above and the appendix to the instruction manual... Figure 1 and 2 It can be seen that, compared with the existing kasugamycin aqueous and soluble formulations, the kasugamycin composition of the present invention can significantly improve the flocculation or precipitation problems that occur when kasugamycin is mixed with other pesticide formulations. The kasugamycin compositions described in Examples 3-29 and 32-33, whether mixed with Chuqiu, Glico, Yinfali, and Lunason, or with Shiga, Youbu, Hainuofei, and Nadiwen, did not form or only slightly flocculated or precipitated, presenting a consistent and homogeneous solution system. This contrasts sharply with Comparative Examples 1-9, which produced obvious or severe flocculation or precipitation. Furthermore, Examples 30 and 31, which can be used for aerial pesticide application with the addition of tank mixing adjuvants, showed no flocculation or precipitation during mixing, not even slight flocculation or precipitation.

[0221] II. Sieving and Nozzle Clogging Test 1. Wet sieve passing rate test method: Referring to the national standard GB / T 16150-1995 "Determination of Fineness of Pesticide Powders and Wettable Powders", weigh 20 mL of the mixed sample and place it in a 50 mL beaker for later use. Completely wet a 200-mesh test sieve, pour the entire mixed sample into the wetted sieve, and then wash with water until the water passing through the sieve is clear and transparent. Transfer the residue in the sieve to a dry beaker, let it stand, and wait for the particles in the beaker to settle to the bottom. Discard most of the water, and dry the residue in a 100℃ oven to constant weight. Remove the beaker and place it in a desiccator to cool to room temperature, then weigh it. The wet sieve passing rate (X)% is calculated using the following formula:

[0222] Where: m1 - weight of the mixed sample (g); m2 - mass of the residue in the beaker (g).

[0223] Based on the results of the above mixing tests, representative examples 4, 6, 8, 15, 21, 25, 27, 28, 29, 30, 31, and 32, which produced slight flocculation or no flocculation or precipitation, and comparative examples 1, 2, 4, 6, and 8, which produced severe flocculation and precipitation, were selected for wet sieve passing rate tests. The results showed that the wet sieve passing rates of examples 4, 6, 8, 15, 21, 25, 27, 28, 29, 30, 31, and 32, after being mixed with other pesticide formulations, were relatively high, reaching over 98%. In contrast, the wet sieve passing rates of comparative examples 1, 2, 4, 6, 8, and 9, after being mixed with other pesticide formulations, were relatively low, below 80%, with comparative examples 1 and 8 even showing a wet sieve passing rate of only around 60%. This result is basically consistent with the results of the aforementioned mixing tests for flocculation and precipitation, indicating that samples producing obvious or severe flocculation or precipitation also had poor wet sieve passing rates. Specific results are shown in the table below.

[0224]

[0225] 2. Nozzle testing method: The test sample is poured into the storage container of the pesticide spraying device, and the pressure pump is manually pushed to force the sample into the pipeline. The sample is repeatedly sprayed in cycles to test the clogging of the pesticide spraying device nozzle and the spray quality.

[0226] Experimental Results: When mixtures of Examples 4, 6, 8, 11, 15, 21, 25, 27, 28, 29, 30, 31, and 32 with other pesticide formulations were poured into pesticide spraying devices for spraying tests, the results showed that mixtures with good wet sieve passing rates did not clog nozzles and produced high-quality sprays. However, mixtures of Comparative Examples 1, 2, 4, 6, 8, and 9 with other pesticide formulations were very prone to nozzle clogging, making it difficult to form a uniform and stable spray. Furthermore, it was found that Examples 4, 6, 8, 11, 15, 21, 25, 27, 28, 29, and 32, as well as Examples 30 and 31 used for aerial pesticide spraying, even when diluted only 50 times and mixed with other pesticide formulations, did not clog nozzles. The sprays produced were uniformly distributed, with moderate concentration, and were continuous and stable, making them highly suitable for aerial or drone pesticide spraying.

[0227] III. Interface Performance Test Test method: The test samples were diluted 200 times with Watson's purified water, and the interfacial properties of the samples were measured using a Kruss contact angle meter (DS-100), a Kruss dynamic surface tension meter (BP-100), a static surface tension meter (JK-99CM), and an electronic balance (accuracy of 0.01g).

[0228] The wetting time test was conducted using the canvas sheet method. The test sample was diluted 200 times with distilled water, and the wetting time of a standard canvas sheet (a round sheet of 21-count * 3-ply * 21-count * 4-ply canvas, 35 mm in diameter, weighing 0.38-0.39 g) on ​​the surface of the test sample was measured. A shorter wetting time indicates lower surface tension and better wettability of the formulation.

[0229] Spreading experiment measurement: Using a high-transparency acrylic plate, place the graph paper under the plate, glue the edges of the two acrylic pieces together, place the graph paper in the middle, and place it flat on a horizontal table. Using a syringe (for a contact angle meter, 0.9mm inner diameter), keep the same height (about 5mm) and slowly drip the liquid onto the acrylic plate, and read the number of grids wetted by the liquid.

[0230] 1. Interfacial properties of the kasugamycin composition

[0231] Experimental Results Description: The experimental results show that the static surface tension and contact angle of the samples in each embodiment are significantly lower than those of the control sample and water. Examples 4, 6, 8, 11, 15, 21, 25, 27, 28, 29, 32, and Examples 30 and 31 show significantly lower static surface tension and contact angle compared to the comparative examples, indicating that the streptomycin composition of the present invention exhibits excellent performance in terms of liquid surface properties (e.g., ...). Figure 3 , Figure 4 and Figure 5 (As shown). In the spreading experiment, the number of wetted grids in each embodiment was significantly greater than that in the control sample and water.

[0232] 2. Interfacial properties of mixtures of kasugamycin and other pesticide formulations

[0233] Description of test results: The test results show that the static surface tension and contact angle of the samples in each example mixed with other pesticide formulations increased slightly, and the number of grids in the spreading test decreased slightly. However, overall, they were still much better than the control group, and the liquid surface performance was still excellent.

[0234] IV. Thermal Storage Stability Test 1. Test methods for thermal storage stability: The sample was sealed in a threaded glass bottle with a polytetrafluoroethylene gasket and placed in a constant temperature oven at 54°C for 14 days. After being removed, the sample was placed in a desiccator and cooled to room temperature. The condition of the sample after heat storage was observed and recorded by taking pictures under direct illumination with a camera.

[0235] Experimental Results: The results showed that the streptomycin compositions in Examples 4, 6, 8, 11, 15, 21, 25, 27, 28, 29, 32, 30, and 31 remained homogeneous and stable after 14 days of heat storage. Figure 6 As shown. However, the streptomycin compositions in Comparative Examples 4, 6, and 8 exhibited significant stratification and localized clumping after 14 days of heat storage, as shown... Figure 6 As shown.

[0236] V. Indoor toxicity testing Test method: Refer to NY / T 1156.11-2008 "Guidelines for Indoor Bioassay of Pesticides - Fungicides Part 11: Pot Test for Control of Powdery Mildew in Cucurbits". The powdery mildew fungus (Podosphaera xanthii) for melon was obtained from the laboratory of the Institute of Plant Protection, Chinese Academy of Agricultural Sciences. Melon was used as the test crop, cultured in pots until the 3-true-leaf stage, and then prepared. Spore suspension preparation: Spores on cucumber leaves infected with powdery mildew were washed with an aqueous solution containing Tween 80, filtered through double-layer gauze, and prepared into a suspension with a spore concentration of 1×10⁵ spores / mL, and then prepared. Test agents were selected from Examples 4, 6, 15, 21, and 25, Comparative Examples 1, 2, and 8, as well as Examples 4 + Early Autumn and Example 25 + Early Autumn, with 5 mass concentration gradients set up for each. First, the prepared spore suspension was sprayed onto the test leaves, allowed to air dry naturally, and then transferred to a greenhouse for cultivation at 20℃-24℃ for 7 days. Seven days later, the pesticide was evenly sprayed onto the melon leaves using a spraying method, and allowed to air dry naturally. Each treatment consisted of three pots, with 3 ml sprayed per pot, and the treatment was repeated four times. A blank control was set up with only a 0.1% Tween-80 aqueous solution. After air drying, the leaves were transferred to a constant temperature room and cultured at 22℃ for 7 days. Based on the disease incidence in the blank control, the disease incidence in each treatment was graded and investigated, with 30 leaves from each treatment examined. The disease index and control effect of each treatment were calculated.

[0237] The disease is graded based on the area of ​​the lesions, and the grading criteria are as follows: Grade 0: Leaves show no disease spots; Grade 1: The lesion area accounts for less than 5% of the total leaf area; Grade 3: Lesions cover 5-15% of the total leaf area; Level 5: Lesions cover 15-25% of the total leaf area; Level 7: Lesions cover 25-50% of the total leaf area; Grade 9: Lesions cover 50%-70% of the entire leaf area; Level 11: The lesion area accounts for more than 75% of the total leaf area; Disease index = {[∑(number of diseased leaves at each treatment level × corresponding level value)] / total number of leaves surveyed × 9} × 100; Prevention and control effect (%) = [(disease index of blank control - disease index of drug treatment) / disease index of blank control group] × 100; The experimental results are shown in the table below, and some of the effects are illustrated in the figure.

[0238] foliar control effect

[0239] Experimental Results: Comparison shows that the control efficacy of Examples 4, 6, 15, 21, 25, and 32 is significantly improved compared to the blank control and Comparative Examples 1, 2, and 8. The kasugamycin composition of this invention, when mixed with *Early Autumn* (Example 4 + *Early Autumn*, Example 21 + *Early Autumn*, Example 25 + *Early Autumn*, and Example 32 + *Early Autumn*), can further enhance the control effect against powdery mildew in melons, indicating that the mixed use of the two drugs improves the fungicidal activity of the agent and can significantly reduce the amount of agent used. The above data indicate that the kasugamycin composition provided by this invention has a good preventive and protective effect against powdery mildew in melons. Observation showed that during the experiment, apart from powdery mildew, no other obvious diseases occurred in the melons, and no phytotoxicity symptoms were observed. The melon plant height and leaf color were normal, indicating that the fungicidal composition provided by this invention is safe.

[0240] VI. Field Trials First, take 25 mL of tap water and add 1 mL of the kasugamycin composition for pesticide aerial spraying shown in Example 4 and Example 30. Then, take another 25 mL of tap water and add 1 mL (or 1 g) of commercially available pesticide Shiga. Finally, mix the two diluted solutions and stir evenly to prepare a kasugamycin composition that can be used for pesticide aerial spraying. Two farmlands with similar disease incidence rates were selected as the pesticide treatment and a blank control, respectively. Following the guidelines for pesticide field efficacy trials, the pesticide was applied using a drone at a dosage of 50 ml / mu (approximately 0.067 hectares) for the first application at the initial stage of disease, followed by a second application 7 days later. Seven days and 14 days after the two applications, surveys were conducted in each plot. Five samples were taken from each plot, with 50 plants collected at each point. The flag leaf and the two leaves below the flag leaf were examined on each plant, and the disease index and control efficacy were calculated.

[0241] Grading method: Grade 0: No lesions; Grade 1: Lesions cover less than 10% of the total leaf area; Grade 3: Lesions cover 11% to 30% of the total leaf area; Grade 5: Lesions cover 31% to 50% of the total leaf area; Grade 7: Lesions cover 51% to 70% of the total leaf area; Grade 9: Lesions cover more than 70% of the total leaf area.

[0242] Drone parameters: Model: DJI, Flight speed: 3m / s, Flight altitude: 2.0m, Spray water consumption: 1.5L / acre.

[0243] The experimental results showed that the control efficacy of the pesticide treatment group Example 4 + Shigao after two applications 14 days were 73.37% and 71.98%, respectively, and the control efficacy of Example 30 + Shigao after two applications 14 days were 74.45% and 72.52%, respectively. This indicates that the kasugamycin composition of the present invention is not only suitable for aerial spraying, but also has a good control effect on rice bacterial blight after field application.

[0244] The above embodiments are preferred embodiments of the present invention, but the embodiments of the present invention are not limited to the above embodiments. Any changes, modifications, substitutions, combinations, or simplifications made without departing from the spirit and principle of the present invention shall be considered equivalent substitutions and shall be included within the protection scope of the present invention.

Claims

1. A streptomycin composition suitable for mixing with pesticide formulations, characterized in that: It contains an active ingredient and adjuvants, wherein the active ingredient is kasugamycin, and the adjuvants include one or more of wetting agents, synergists, and dispersants; preferably, the adjuvants also include penetrants.

2. The streptomycin composition according to claim 1, suitable for mixing with pesticide formulations, characterized in that: The synergist is selected from one or more of alkyl sulfonates, alkyl sulfates, and alkyl ether sulfates; Preferably, the synergist is selected from one or more of sodium ethoxylated alkyl sulfate, sodium fatty alcohol polyoxyethylene ether sulfate, alkyl ethyl sulfonate, and sodium lauryl ether sulfate.

3. The streptomycin composition according to claim 1, suitable for mixing with pesticide formulations, characterized in that: The penetrant is selected from one or more of polyethers, polyoxyethylene ethers, and fatty acid esters; Preferably, the polyoxyethylene ethers include one or more of castor oil polyoxyethylene ethers, fatty alcohol polyoxyethylene ethers, alkylphenol polyoxyethylene ethers, isomeric alcohol polyoxyethylene ethers, and alkyl glycosides; More preferably, the penetrant is selected from one or more of EOPO block polyether, hydroxyl polyethylene oxide block copolymer, polyether segment semi-branched ethoxylate, castor oil polyoxyethylene ether, fatty alcohol polyoxyethylene ether, octylphenol polyoxyethylene ether, nonylphenol polyoxyethylene ether, octylphenol polyoxyethylene ether, polyethylene glycol p-isooctylphenyl ether, Span, Tween, isodecyl alcohol polyoxyethylene ether, isodecyl alcohol polyether, and alkyl glycosides.

4. The streptomycin composition according to claim 1, suitable for mixing with pesticide formulations, characterized in that: The dispersant is selected from high molecular weight carboxylate polymers and / or polyoxyethylene ether phosphates; preferably, the polyoxyethylene ether phosphates include one or more of fatty alcohol ether polyoxyethylene ether phosphates, isomeric alcohol ether polyoxyethylene ether phosphates, alkylphenol polyoxyethylene ether phosphates, and arylphenol polyoxyethylene ether phosphates. More preferably, the dispersant is selected from one or more of the following: sodium polycarboxylate, ammonium polycarboxylate, potassium polycarboxylate, lauryl alcohol polyoxyethylene ether phosphate, octyl alcohol polyoxyethylene ether phosphate, isooctyl alcohol polyoxyethylene ether phosphate, nonylphenol polyoxyethylene ether phosphate, octylphenol polyoxyethylene ether phosphate, phenol polyoxyethylene ether phosphate, and tristyrene-phenol polyoxyethylene ether phosphate.

5. A streptomycin composition suitable for mixing with pesticide formulations according to claim 1, characterized in that: The wetting agent is selected from alkyl sulfonates and / or phosphate esters and their salts; preferably, the phosphate esters and their salts are selected from one or more of fatty alcohol ether phosphate esters, phenolic ether phosphate esters, isomeric alcohol phosphate esters, alkyl phosphate esters, potassium salts of fatty alcohol ether phosphate esters, potassium salts of phenolic ether phosphate esters, potassium salts of isomeric alcohol ether phosphate esters, and potassium salts of alkyl phosphate esters. More preferably, the wetting agent is selected from one or more of the following: sodium dioctyl succinate, sodium diisooctyl maleate sulfonate, calcium dodecylbenzene sulfonate, ammonium dodecylbenzene sulfonate, potassium dodecylbenzene sulfonate, sodium dodecylbenzene sulfonate, isooctanol phosphate, potassium isooctanol phosphate, isotrimethylene ether phosphate, potassium isotridecyl ether phosphate, lauryl phosphate, potassium lauryl phosphate, fatty alcohol ether phosphate, potassium fatty alcohol ether phosphate, phenolic ether phosphate, and potassium phenolic ether phosphate.

6. A streptomycin composition suitable for mixing with pesticide formulations according to claim 1, characterized in that: The kasugamycin composition also includes an antifreeze agent.

7. A streptomycin composition suitable for mixing with pesticide formulations according to claim 6, characterized in that: The antifreeze is selected from one or more of ethylene glycol, propylene glycol, glycerol, urea, propylene glycol methyl ether, ethylene glycol butyl ether, propylene glycol butyl ether, diethylene glycol dibutyl ether, ethylene glycol phenyl ether, and propylene glycol phenyl ether.

8. A streptomycin composition suitable for mixing with pesticide formulations according to claim 1, characterized in that: The mass ratio of the wetting agent, synergist and dispersant is (1-10):(1-10):(1-10). The preferred ratio is (1-5):(1-5):(1-5); Preferably, the adjuvant further includes a penetrant, and the mass ratio of the wetting agent, synergist, penetrant and dispersant is (1-10):(1-10):(1-10):(1-10); preferably (1-5):(1-5):(1-5):(1-5).

9. A streptomycin composition suitable for mixing with pesticide formulations according to claim 1, characterized in that: The streptomycin composition also includes an antifoaming agent and a preservative.

10. A streptomycin composition suitable for mixing with pesticide formulations according to claim 9, characterized in that: The defoamer is one or more of the following: polyether-modified organosilicon, organosiloxane, organosilicone, modified organosilane, and organosilicon.

11. A streptomycin composition suitable for mixing with pesticide formulations according to claim 9, characterized in that: The preservative is one or more of Kathon, sodium benzoate, isothiazolinone, benzisothiazolinone, sodium methylparaben, and ethylparaben.

12. A streptomycin composition suitable for mixing with pesticide formulations according to any one of claims 1-11, characterized in that: The pesticide formulation is a suspension concentrate or a water-dispersible granule; Optionally, the kasugamycin composition suitable for mixing with pesticide formulations is an aqueous solution (AS), a soluble concentrate (SL), a powder (DP), a wettable powder (WP), a soluble powder (SP), a suspension concentrate (SC), a water-dispersible granule (WG), a pellet (GR), or a soluble granule (SG).

13. A streptomycin composition suitable for mixing with pesticide formulations according to claim 12, characterized in that: It also includes barrel mixing additives.

14. A streptomycin composition suitable for mixing with pesticide formulations according to claim 13, characterized in that: The barrel mixing additive is selected from alkyl sulfonates and / or phosphate esters and their salts; preferably, the phosphate esters and their salts are selected from one or more of fatty alcohol ether phosphate esters, phenolic ether phosphate esters, isomeric alcohol phosphate esters, alkyl phosphate esters, potassium salts of fatty alcohol ether phosphate esters, potassium salts of phenolic ether phosphate esters, potassium salts of isomeric alcohol ether phosphate esters, and potassium salts of alkyl phosphate esters; more preferably, the barrel mixing additive is selected from one or more of sodium dioctyl succinate, sodium diisooctyl maleate sulfonate, calcium dodecylbenzene sulfonate, ammonium dodecylbenzene sulfonate, potassium dodecylbenzene sulfonate, sodium dodecylbenzene sulfonate, isooctanol phosphate ester, potassium isooctanol phosphate ester, isotrimethylene ether phosphate ester, potassium isotridecyl ether phosphate ester, lauryl phosphate ester, potassium lauryl phosphate ester, fatty alcohol ether phosphate ester, potassium fatty alcohol ether phosphate ester, phenolic ether phosphate ester, and potassium phenolic ether phosphate esters; Preferably, the mass ratio of the mixing agent to the wetting agent is 5-15:

1.

15. Use of the kasugamycin composition according to any one of claims 1-14 in combination with pesticide formulations.

16. The use of the streptomycin composition according to any one of claims 1-14 in the prevention and control of plant diseases.

17. The use of the streptomycin composition according to any one of claims 1-14 in the preparation of plant disease control agents.

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