A spray composition for cat mood relaxation and sleep aid, and a preparation method and application thereof

Abstract

The application discloses a spray composition for cat mood alleviation and sleep aid and application thereof. The spray composition contains, in percentage by weight, 1-8% of a cat facial pheromone analogue, 1-8% of gamma-aminobutyric acid, 0.01-0.5% of L-theanine, 0.001-0.05% of a magnesium salt, 1-10% of glycerol, 0.01-0.2% of potassium sorbate, 0.1-1% of a lactic acid solution, and the balance of water. After the spray composition is inhaled by a cat in the form of micro-particles, the cat's stress behavior can be significantly alleviated within 5-10 minutes. The spray composition is convenient to use, is especially suitable for a stress scene such as pet medical treatment, and can also be used in various scenes such as moving.

Description

Technical Field

[0001] This invention relates to the field of pet product technology, specifically to a spray composition for soothing and aiding sleep in cats, its preparation method, atomization system, and applications. Background Technology

[0002] Cats are highly sensitive companion animals, and their emotional stability is easily affected by changes in the external environment. Studies have shown that cats have a strong sense of territory and are highly sensitive to stressors such as unfamiliar smells, noises, spatial changes, and alterations in their social environment. These stimuli can rapidly activate their sympathetic nervous system and the hypothalamic-pituitary-adrenal (HPA) axis, leading to a surge in cortisol secretion, inducing persistent anxiety, fear, and stress responses, and depleting a significant amount of the body's reserves. Furthermore, a cat's olfactory system is approximately 14 times more sensitive than that of humans, making its recognition of olfactory information and its stress response particularly strong. Therefore, how to quickly, safely, and conveniently alleviate stress in cats is an important need in pet care and clinical practice.

[0003] For stress relief in cats, products on the market can be mainly divided into three categories: The first category is pheromone diffusion products, such as air diffusers that mimic the F3 pheromone in a cat's face. These diffuse pheromones act on the vomeronasal system of the cat, reducing environmental alertness. While these products have a certain soothing effect, they usually rely on a continuous accumulation of concentration in the environment, have a long onset time, and are limited in effectiveness in acute stress scenarios. The second category is oral soothing products, which typically contain ingredients such as gamma-aminobutyric acid (GABA), L-theanine, tryptophan, or various plant extracts. They exert a calming effect through nutritional or neuromodulatory pathways. However, these products are greatly affected by gastrointestinal absorption efficiency and individual differences, resulting in a slower overall onset of action. Furthermore, cats' tolerance to oral administration is somewhat limited. The third category is spray products, mostly used only for environmental odor adjustment or mild soothing.

[0004] Among the three types of products mentioned above, pheromone diffusion products have a slower onset of action and limited effectiveness in acute stress scenarios; oral soothing products are limited by gastrointestinal absorption and have a slower onset of action; and spray products are mostly used only for environmental odor adjustment or mild soothing and are not suitable as routine stress intervention methods. Summary of the Invention

[0005] In view of the above-mentioned problems of existing cat stress relief products, the present invention provides a spray composition for cat emotional relief and sleep aid, its preparation method and application. The spray composition is used in spray form, which is convenient and quick, and can achieve cat emotional intervention within 5 to 10 minutes.

[0006] The present invention adopts the following technical solution: In a first aspect, the present invention provides a spray composition for soothing and aiding sleep in cats, the spray composition comprising, by weight percentage: Feline facial pheromone analogs: 1%~8%; γ-Aminobutyric acid: 1%~8%; L-Theanine: 0.01%~0.5%; Magnesium salts: 0.001%~0.05%; Glycerin: 1%~10%; Potassium sorbate: 0.01%~0.2%; Lactic acid solution: 0.1%~1%; Water: Balance.

[0007] Preferably, the magnesium salt is selected from one or more of magnesium chloride, magnesium lactate, magnesium glycine, and magnesium citrate.

[0008] Preferably, the spray composition is in liquid form.

[0009] Preferably, the pH of the spray composition is 4.0 to 4.8.

[0010] Preferably, the content of the cat facial pheromone analog is 2% to 8%, the content of the γ-aminobutyric acid is 3% to 6%, and the content of the L-theanine is 0.05% to 0.2%.

[0011] Preferably, after the microparticles formed by the spray composition are inhaled by the cat, they produce a cat behavior improvement effect within 5 to 10 minutes. The behavior improvement includes one or more of the following: reduced activity, decreased persistent alertness, reduced vocalization, relaxed posture, increased lying down, and enhanced voluntary resting behavior.

[0012] Preferably, the spray composition is used in one or more of the following scenarios: transportation stress, medical examination, bathing and beauty, separation anxiety, multi-pet conflict, nocturnal restlessness, and adaptation to unfamiliar environments.

[0013] Secondly, the present invention also provides a method for preparing the above-mentioned spray composition, the method comprising the following steps: (1) Add γ-aminobutyric acid and L-theanine to purified water and stir and mix at a temperature not higher than 20°C until they are completely dissolved to form a homogeneous and transparent system; (2) Add magnesium salt and continue stirring until the system is homogeneous; (3) Add the feline facial pheromone analogue at a temperature not exceeding 20°C and mix thoroughly; (4) Add potassium sorbate and mix well, then adjust the pH of the system to 4.0~4.8 using lactic acid solution; (5) The spray composition is obtained by filling under low temperature and sterile conditions.

[0014] Thirdly, the present invention also provides a nebulization system for soothing and aiding sleep in cats, comprising the spray composition described in the first aspect, and a portable micro-nebulization device.

[0015] Preferably, the portable micro-atomizing device is equipped with an atomizing component, which is selected from one or more of ultrasonic atomizing plates, microporous piezoelectric ceramic atomizing plates, or capillary core components with heating elements; the atomizing component is configured to atomize the spray composition into aerosol particles with a particle size in the range of 1 μm to 5 μm.

[0016] Fourthly, the present invention also provides the use of the spray composition described in the first aspect in the preparation of cat mood-soothing and sleep-aiding products.

[0017] Compared with the prior art, the beneficial effects of the present invention are as follows: The spray composition provided by this invention is used in the form of a spray, which is convenient and quick. It can achieve cat emotional intervention within 5 to 10 minutes and is suitable for cat emotional relief in scenarios such as transportation stress, medical examination, grooming, separation anxiety, multi-pet conflict, nighttime restlessness, and adaptation to unfamiliar environments. Attached Figure Description

[0018] To more clearly illustrate the technical solutions in the embodiments of the present invention, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0019] Figure 1 Normalized statistical charts of feline social behavior under different treatment conditions. Higher social behavior scores indicate more pronounced stress responses or abnormal behaviors.

[0020] Figure 2 Normalized statistical graphs of sleep latency in cats under different treatment conditions. A higher sleep latency indicates greater difficulty falling asleep.

[0021] Figure 3 This chart presents a statistical summary of the overall behavioral and emotional state scores of cats under different treatment conditions. The overall score is calculated by combining indicators such as startle response, avoidance behavior, alertness, vocalization, and abnormal activity. The scoring logic references the feline stress rating scale. A higher overall score indicates a more pronounced stress response or abnormal behavior. For example, a higher score indicates that the cat is closer to a state of panic and may exhibit avoidance behaviors such as hiding. Detailed Implementation

[0022] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to specific embodiments. It should be understood that the specific embodiments described herein are for illustrative purposes only and are not intended to limit the scope of protection of this invention.

[0023] The spray composition for soothing and aiding sleep in cats provided by this invention comprises, by weight percentage: feline facial pheromone analogue: 1%~8%; γ-aminobutyric acid: 1%~8%; L-theanine: 0.01%~0.5%; magnesium salt: 0.001%~0.05%; glycerol: 1%~10%; potassium sorbate: 0.01%~0.2%; lactic acid solution: 0.1%~1%; water: balance.

[0024] The core active components of this spray composition are feline facial pheromone analogs and gamma-aminobutyric acid (GABA). The components of the feline facial pheromone analogs are highly homologous to the natural F3 pheromone secreted by the cat's cheek glands and can be recognized by the vomeronasal organ, rapidly reducing the cat's alertness to unfamiliar environments and stressors. GABA is an important inhibitory neurotransmitter in the mammalian central nervous system. It can cross the blood-brain barrier and bind to GABA receptors on the postsynaptic membrane of neurons, reducing neuronal excitability and alleviating anxiety at the neural pathway level.

[0025] Compared to spray compositions containing only cat facial pheromone analogs or GABA, the spray composition containing cat facial pheromone analogs and GABA provided by the present invention performs better in improving feline social behavior and sleep latency.

[0026] The L-theanine in the spray composition provided by this invention is a natural non-protein amino acid extracted from green tea. It can cross the blood-brain barrier to promote the generation of alpha waves in the brain, relieving anxiety without causing drowsiness. L-theanine has extremely high safety, no dependence with long-term use, and is suitable for cats of all ages and health conditions.

[0027] Magnesium ions in the spray composition are an important element for maintaining the normal excitability of the nervous system. The spray composition of the present invention regulates nerve excitability and reduces stress sensitivity through magnesium ions.

[0028] This spray composition uses glycerin, potassium sorbate, and lactic acid solution as excipients. Glycerin, as a humectant, enhances the stability of the atomized particles, prolongs their suspension time in the air, and moisturizes the cat's respiratory mucosa, preventing atomization irritation. Furthermore, glycerin improves palatability and increases licking acceptance. Potassium sorbate is an internationally recognized safe food-grade preservative that effectively inhibits microbial growth at concentrations of 0.01% to 0.2% without irritating cats. Lactic acid solution is used to adjust the system pH to 4.0 to 4.8, a pH range close to that of cat skin and mucous membranes, minimizing irritation during use and enhancing the chemical stability of the active ingredients.

[0029] In some embodiments of the present invention, the magnesium salt is selected from one or more of magnesium chloride, magnesium lactate, magnesium glycine, and magnesium citrate. All of the above magnesium salts are highly bioavailable water-soluble magnesium sources. Among them, magnesium chloride has the best water solubility and can be rapidly dispersed in aqueous systems, making it suitable for scenarios requiring short-time preparation. Magnesium glycine, using amino acids as carriers, has an absorption efficiency more than 40% higher than inorganic magnesium salts and is less irritating to mucous membranes. Magnesium lactate and magnesium citrate are organic weak acid magnesium salts, which, after dissociation, can simultaneously act as pH buffers, further improving system stability.

[0030] In some embodiments of the present invention, the spray composition exists in liquid form and is converted into aerosol particles for cats to inhale using a portable micro-atomizing device.

[0031] A low content of 1% of cat facial pheromone analogue can meet the daily environmental stability requirements, while a high content of 8% can quickly reduce alertness in severe stress scenarios such as transportation and medical treatment. In some embodiments of the present invention, the content of the cat facial pheromone analogue is preferably 2% to 8%.

[0032] When the content of γ-aminobutyric acid is below 3%, the inhibitory effect on nerves is insufficient; when it is above 6%, there is no additional effect gain and the cost is increased. In some embodiments of the present invention, the content of γ-aminobutyric acid is preferably 3% to 6%.

[0033] In some embodiments of the present invention, the content of L-theanine is 0.05% to 0.2%, which can help relieve anxiety without causing drowsiness.

[0034] In some embodiments of the present invention, after the microparticles formed by the spray composition are inhaled by the cat, they produce a cat behavior improvement effect within 5 to 10 minutes. The behavior improvement includes one or more of the following: reduced activity, decreased persistent alertness, reduced vocalization, relaxed posture, increased lying down, and enhanced voluntary resting behavior.

[0035] Preferably, the applicable scenarios for the spray composition include, but are not limited to, transportation stress, medical examinations, grooming, separation anxiety, multi-pet conflicts, nocturnal restlessness, and adaptation to unfamiliar environments. The intervention effects in each scenario are as follows: Transportation stress significantly reduces vestibular stimulation-induced vomiting in cats, and decreases abnormal vocalizations and rapid breathing; medical examinations reduce cats' alertness to unfamiliar environments and unfamiliar individuals, and reduce the interference of stress-induced high body temperature and resistance behaviors on examination procedures; grooming weakens cats' aversion to water sounds and airflow noise, and reduces the incidence of aggressive behavior; separation anxiety alleviates excessive vocalization and abnormal excretion behaviors in cats after their owners leave; multi-pet conflicts reduce the incidence of confrontational and threatening behaviors related to territorial disputes; nocturnal restlessness shortens the sleep latency period and reduces abnormal nocturnal activity; and adaptation to unfamiliar environments increases cats' acceptance of new living spaces and boarding facilities, and reduces avoidance behaviors and feeding inhibition.

[0036] The present invention also provides a method for preparing the above-mentioned spray composition, comprising the following steps: (1) adding γ-aminobutyric acid and L-theanine to purified water, stirring and mixing at a temperature not exceeding 20°C until they are completely dissolved to form a uniform and transparent system; (2) adding magnesium salt and continuing to stir until the system is uniform; (3) adding cat facial pheromone analogue at a temperature not exceeding 20°C and mixing thoroughly; (4) adding potassium sorbate and mixing well, and then adjusting the pH of the system to 4.0~4.8 using lactic acid; (5) filling under low temperature and sterile conditions to obtain the spray composition.

[0037] The present invention also provides an atomization system for calming and promoting sleep in cats, including the above-described spray composition, and a portable micro-atomization device.

[0038] In some embodiments of the present invention, the portable micro-atomizing device is configured with an atomizing component selected from one or more of an ultrasonic atomizing plate, a microporous piezoelectric ceramic atomizing plate, or a capillary wick assembly with a heating element; the atomizing component is configured to atomize the spray composition into aerosol particles with a particle size in the range of 1 μm to 5 μm.

[0039] The present invention also provides the use of the above-described spray composition in the preparation of cat mood-relieving and sleep-aiding products.

[0040] The feline facial pheromone analogs used in the following examples contain the following components by weight percentage: 15% palmitic acid, 10% azelaic acid, 10% pimecrolic acid, 8% lauric acid, 8% ethyl palmitate, 4% ethyl oleate, 4% decanoic acid, 3.49% linoleic acid, 1.10% methyl linoleate, 0.85% methyl palmitate, 0.28% methyl laurate, and 0.28% methyl myristate, with the balance being oleic acid.

[0041] Preparation method of feline facial pheromone analogues: Accurately weigh each fatty acid and ester component according to the above-mentioned mass percentages; first, mix oleic acid, linoleic acid, palmitic acid, azelaic acid, pimelic acid, lauric acid, and decanoic acid, then add ethyl palmitate, ethyl oleate, methyl linoleate, methyl palmitate, methyl laurate, and methyl myristate. Stir this step under light-protected conditions and at a temperature below 25°C until the system is homogeneous to obtain the feline facial pheromone analogue.

[0042] The lactic acid solution used in the following examples consists of lactic acid and water, with lactic acid accounting for 80% by mass.

[0043] Example 1

[0044] The spray composition for soothing and aiding sleep in cats provided in this embodiment contains, by weight percentage: 5% feline facial pheromone analogue, 5% GABA, 0.1% L-theanine, 0.02% magnesium chloride, 5% glycerol, 0.1% potassium sorbate, 0.375% lactic acid solution, with the balance being water and a pH of 4.5.

[0045] The preparation method of the spray composition for soothing and aiding sleep in cats provided in this embodiment includes the following steps: (1) Add GABA and L-theanine to purified water and stir at 20°C until the raw materials are completely dissolved to form a uniform and transparent solution system.

[0046] (2) Add magnesium chloride to the above solution system and stir continuously until the mixture is uniform to ensure that magnesium ions are fully dispersed in the aqueous phase.

[0047] (3) Add cat facial pheromone analogue at 20°C and stir thoroughly to ensure that the cat facial pheromone analogue is evenly dispersed in the aqueous phase.

[0048] (4) Add potassium sorbate and mix well, then use lactic acid solution to adjust the pH of the whole system to 4.5.

[0049] (5) The final solution is aseptically filled at low temperature to obtain the spray composition.

[0050] Example 2

[0051] The spray composition for soothing and aiding sleep in cats provided in this embodiment contains, by weight percentage: 2% feline facial pheromone analogue, 3% GABA, 0.05% L-theanine, 0.02% magnesium chloride, 5% glycerol, 0.1% potassium sorbate, 0.375% lactic acid solution, with the balance being water and a pH of 4.5.

[0052] The preparation method of the spray composition for soothing and aiding sleep in cats provided in this embodiment is the same as that in Example 1.

[0053] Example 3

[0054] The spray composition for soothing and aiding sleep in cats provided in this embodiment contains, by weight percentage: 8% feline facial pheromone analogue, 6% GABA, 0.2% L-theanine, 0.02% magnesium chloride, 5% glycerol, 0.1% potassium sorbate, 0.375% lactic acid solution, with the balance being water and a pH of 4.5.

[0055] The preparation method of the spray composition for soothing and aiding sleep in cats provided in this embodiment is the same as that in Example 1.

[0056] Comparative Example 1 The comparative example provides a spray composition for soothing and aiding sleep in cats, comprising, by weight percentage: 10% feline facial pheromone analogue, 0.1% L-theanine, 0.02% magnesium chloride, 5% glycerol, 0.1% potassium sorbate, 0.375% lactic acid solution, with the balance being water, and a pH of 4.5.

[0057] The preparation method of the spray composition for soothing and aiding sleep in cats provided in this comparative example is the same as that in Example 1.

[0058] Comparative Example 2 The comparative example provides a spray composition for soothing and aiding sleep in cats, comprising, by weight percentage: 10% GABA, 0.1% L-theanine, 0.02% magnesium chloride, 5% glycerol, 0.1% potassium sorbate, 0.375% lactic acid solution, with the balance being water, and a pH of 4.5.

[0059] The preparation method of the spray composition for soothing and aiding sleep in cats provided in this comparative example is the same as that in Example 1.

[0060] Example 4: Behavioral Verification 1. The test cats were randomly divided into five groups: (1) Blank group: quiet environment; (2) Stimulation group: sound stimulation only; (3) Stimulation + F3 analog intervention group: sound stimulation, and spraying with the spray composition prepared in Comparative Example 1; (4) Stimulation + GABA intervention group: sound stimulation, and spraying with the spray composition prepared in Comparative Example 2; (5) Stimulation + Composition Intervention Group: Sound stimulation, and spraying with the spray composition prepared in Example 1; The sample size of each group of test cats was 20, and the sex and weight of individuals in each group were matched as much as possible. Five minutes before the sound stimulation, the corresponding intervention was released by nebulizing the cats using an M12 portable micro-nebulizer, with each nebulization lasting 30 seconds. The sound stimulation used was a standardized stimulus with the same volume and duration.

[0061] 2. Social behavior and sleep latency scores Behavioral recording methods were used to score the social behavior of the cats, and the sleep latency of the cats was measured by time, referring to the professional method of the Multiple Sleep Latency Test (MSLT). This test is one of the most accurate electrophysiological methods for quantitatively evaluating the degree of sleepiness. During the test, the cats were allowed to nap at fixed intervals in a quiet, comfortable, and dimly lit environment, and the duration of sleep was recorded.

[0062] The mean of the blank group was normalized to 100%. The lower the social behavior score or the sleep latency, the less stress and the better the relief effect. The differences between groups were compared by one-way ANOVA. The Tukey HSD method was used for multiple comparisons between groups. p < 0.05 was considered significant.

[0063] The social behavior score is used to quantify stress responses such as sustained alertness, avoidance behavior, abnormal vocalizations, and abnormal activity; the sleep latency is defined as the time from the end of the stimulus to the time it takes for the subject cat to continuously enter a state of rest or sleep. Figure 1 , Figure 2 In the study, social behavior scores and sleep latency data were normalized as percentages of the control group's mean: the social behavior scores of the stimulation group, stimulation + F3 analog intervention group, stimulation + GABA intervention group, and stimulation + composition intervention group were 120.23%, 100.23%, 118.24%, and 60.37% of the control group, respectively; the sleep latency were 116.49%, 112.23%, 98.24%, and 56.94% of the control group, respectively. One-way ANOVA showed statistically significant differences between groups (p < 0.05). Both indicators in the stimulation + composition intervention group were significantly lower than those in the stimulation + F3 analog intervention group and the stimulation + GABA intervention group, indicating that the spray composition provided in Example 1 was more effective than either the F3 analog alone or the GABA alone in improving stress behavior and shortening sleep latency.

[0064] Example 5: Scoring the behavior and emotional state of the test cats. 1. The test cats were randomly divided into 3 groups: (1) Blank group: quiet environment; (2) Stimulation group: sound stimulation; (3) Stimulation + Intervention Group: Sound stimulation, and spraying with the spray composition prepared in Example 1; The sample size of each group of test cats was 20, and the sex and weight of individuals in each group were matched as much as possible. Five minutes before the sound stimulation, the corresponding intervention was released by nebulizing the cats using an M12 portable micro-nebulizer, with each nebulization lasting 30 seconds. The sound stimulation used was a standardized stimulus with the same volume and duration.

[0065] 2. Score the cat based on its specific behaviors after stress: Startle response is indicated by physiological changes such as dilated pupils, increased heart rate, and rapid breathing, as well as behavioral behaviors such as ruffled fur and drooling; avoidance behavior is indicated by hiding in a quiet, dark corner or climbing to hide; alertness is indicated by dilated pupils, tail close to the body, and cautious gait; vocalization is indicated by low growls or sharp hisses; abnormal activity is indicated by running around, remaining still, or being listless.

[0066] In the rating scale, five indicators—startle response, avoidance behavior, alertness, vocalization, and abnormal activity—were each rated from 1 to 5 points, and the scores were summed to obtain the comprehensive stress score. A higher comprehensive stress score indicates a more significant stress response. The decrease in the comprehensive stress score of the stimulus + intervention group compared to the stimulus group, as well as the comparison of the comprehensive stress scores of each group with the control group, were analyzed using one-way ANOVA. Multiple comparisons between groups were performed using the Tukey HSD method. According to professional statistical analysis guidelines, this method has rigorous practical application value in comparing differences between groups, and p < 0.05 was considered significant.

[0067] The descriptive statistics of the overall stress scores for each group are as follows (see Figure 3 The scores were as follows: 8.30±1.38 in the blank group, 15.45±2.04 in the stimulation group, and 6.90±0.97 in the stimulation + intervention group. The score in the stimulation + intervention group was approximately 55.3% lower than that in the stimulation group and also lower than that in the blank group, indicating that the spray composition prepared in Example 1 not only effectively relieves stress response but also has a certain relaxing and sleep-inducing effect. The difference between the groups was statistically significant (p<0.05). During the observation period, the gait, respiratory rate, body position, and abnormal sedation of the test cats were recorded. No obvious gait abnormalities, respiratory depression, or excessive behavioral inhibition were found.

[0068] Example 6: Verification of Onset Time 5 mL of the spray composition solution described in Example 1 was filled into a 5 mL glass bottle that comes with the MEKLIFE M12 portable electronic sprayer. The device has a rod size of approximately φ23.5 mm × 78 mm (excluding the bottle), a rated liquid capacity of 5 mL, and produces an aerosol with an average particle size of 4 μm. Each atomization session lasts 30 seconds, and 5 mL of liquid can be atomized approximately 25 times, resulting in an average consumption of approximately 0.20 mL per session.

[0069] Twenty-four cats exhibiting significant anxiety behavior after standardized stress induction were randomly divided into an experimental group and a control group, with 12 cats in each group. The experimental group received the spray composition of Example 1 using the M12 nebulizer described above, with each nebulization lasting 30 seconds. The control group received a blank nebulizer solvent without active ingredients (the excipient composition was the same as in Example 1, except it lacked feline facial pheromone analogs, γ-aminobutyric acid, L-theanine, and magnesium chloride). At 3, 5, 10, and 15 minutes after nebulization, the cats were assessed using the scoring method of Example 5, which included five items: startle response, avoidance behavior, alertness, vocalization, and abnormal activity. Each item was scored from 1 to 5 points, with a higher total score indicating a more pronounced stress response.

[0070] The results showed that the experimental group cats experienced a significant decrease in their overall stress score within 5 minutes of nebulization, and the score was reduced by an average of 52.7% at 10 minutes. The onset time was significantly shorter than that of pheromone diffusion products, such as MAG pheromone spray, which requires 15 minutes to quickly relieve anxiety. The effects included reduced activity, decreased alertness, reduced vocalization, relaxed posture, increased lying down, and enhanced voluntary resting behavior. No abnormal gait or excessive sedation was observed during the observation period. The control group showed no significant behavioral improvement during the same time period.

[0071] The above embodiments are merely preferred embodiments of the present invention and are not intended to limit the scope of protection of the present invention. Without departing from the core concept of the present invention, those skilled in the art can make reasonable changes to the component content, magnesium salt type, atomizing device type, and specific application, and all such changes fall within the scope of protection of the present invention.

Claims

1. A spray composition for soothing and promoting sleep in cats, characterized in that, By weight percentage, it contains the following components: Feline facial pheromone analogs: 1%~8%; γ-Aminobutyric acid: 1%~8%; L-Theanine: 0.01%~0.5%; Magnesium salts: 0.001%~0.05%; Glycerin: 1%~10%; Potassium sorbate: 0.01%~0.2%; Lactic acid solution: 0.1%~1%; Water: Balance.

2. The spray composition according to claim 1, characterized in that, The magnesium salt is selected from one or more of magnesium chloride, magnesium lactate, magnesium glycine, and magnesium citrate.

3. The spray composition according to claim 1, characterized in that, The cat facial pheromone analogue, by weight percentage, comprises: 15% palmitic acid, 10% azelaic acid, 10% pimelic acid, 8% lauric acid, 8% ethyl palmitate, 4% ethyl oleate, 4% decanoic acid, 3.49% linoleic acid, 1.10% methyl linoleate, 0.85% methyl palmitate, 0.28% methyl laurate, and 0.28% methyl myristate, with the balance being oleic acid.

4. The spray composition according to claim 1, characterized in that, The spray composition is in liquid form.

5. The spray composition according to claim 1, characterized in that, The pH of the spray composition is 4.0 to 4.

8.

6. The spray composition according to claim 1, characterized in that, The content of the cat facial pheromone analog is 2%~8%, the content of the γ-aminobutyric acid is 3%~6%, and the content of the L-theanine is 0.05%~0.2%.

7. The spray composition according to claim 1, characterized in that, When the microparticles formed by the spray composition are inhaled by the cat, they produce a behavioral improvement effect within 5 to 10 minutes. The behavioral improvement includes one or more of the following: reduced activity, decreased persistent alertness, reduced vocalization, relaxed posture, increased lying down, and enhanced voluntary resting behavior.

8. A method for preparing the spray composition according to any one of claims 1 to 7, characterized in that, Includes the following steps: (1) Add γ-aminobutyric acid and L-theanine to purified water and stir and mix them at a low temperature of no more than 20°C until they are completely dissolved to form a homogeneous and transparent system; (2) Add magnesium salt and continue stirring until the system is homogeneous; (3) Add the feline facial pheromone analogue at a low temperature not exceeding 20°C and mix thoroughly; (4) Add potassium sorbate and mix well, then adjust the pH of the system to 4.0~4.8 using lactic acid solution; (5) The spray composition is obtained by filling under low temperature and sterile conditions.

9. A nebulization system for soothing and aiding sleep in cats, characterized in that, The invention includes the spray composition according to any one of claims 1 to 7, and a portable micro-atomizing device; the portable micro-atomizing device is configured to convert the spray composition into microparticles.

10. The use of the spray composition according to any one of claims 1 to 7 in the preparation of cat mood-relieving and sleep-aiding products.

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