A zhangliang ginger compound composition for improving androgenetic alopecia

Abstract

The present application relates to the technical field of hair care, and discloses a Zhangliang ginger compound composition for improving androgenetic alopecia, which is made from the following raw materials in parts by weight: Zhangliang ginger extract 20-35 parts, cypress leaf extract 15-25 parts, radix polygoni multiflori extract 10-20 parts, penetration enhancer 3-8 parts, and ethanol 60-80 parts; by limiting the content standards of total gingerols and total curcuminoids in the Zhangliang ginger extract, total flavonoids in the cypress leaf extract, and stilbene glucoside in the radix polygoni multiflori extract, the quality and pharmacodynamic material basis of each core extract are ensured; by specifying the specific preparation methods of the Zhangliang ginger extract, the cypress leaf extract, and the radix polygoni multiflori extract, including the process parameters such as crushing particle size, solvent concentration, reflux extraction, and concentration drying, the active ingredients in the medicinal materials are extracted, and combined with the penetration enhancer, various forms of topical external preparations are prepared, and the effectiveness of the composition is ensured.

Description

Technical Field

[0001] This invention relates to the field of hair care technology, specifically to a compound composition of Ginger in Chinese angelica for improving androgenetic alopecia. Background Technology

[0002] In recent years, the proportion of people experiencing hair loss has been increasing and is showing a trend towards affecting younger people. Hair loss phenomena include alopecia areata, stress-related hair loss, and androgenetic alopecia. Among these, the majority of people experiencing hair loss suffer from androgenetic alopecia. The main mechanism is that testosterone is converted into dihydrotestosterone, which has higher biological activity, under the action of 5α-reductase. This competitively inhibits the binding of testosterone to its receptor. This process inhibits the metabolic process, prevents dormant hair follicles from entering the growth phase, and causes the hair follicles to gradually shrink until they disappear, resulting in hair loss.

[0003] Currently, in the research and development or production of traditional compound compositions for improving androgenetic alopecia, herbal extracts are often used directly without clearly defining the content of their core active ingredients. This results in an unclear pharmacodynamic material basis for the composition, making it difficult to guarantee the stability of product quality and efficacy.

[0004] Therefore, a compound composition of Ginger sibiricum for improving androgenetic alopecia is proposed to solve the above problems. Summary of the Invention

[0005] To address the shortcomings of existing technologies, this invention provides a compound composition of Ginger in Chinese yam for improving androgenetic alopecia, which solves the problem that the pharmacodynamic material basis of the compositions mentioned in the background art is unclear, making it difficult to guarantee the stability of product quality and efficacy.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a compound composition of angelica sinensis for improving androgenetic alopecia, made from the following raw materials in parts by weight: 20-35 parts of Ginger extract, 15-25 parts of Platycladus orientalis leaf extract, 10-20 parts of Polygonum multiflorum extract, 3-8 parts of penetration enhancer, and 60-80 parts of ethanol; The *Zhang Liang Jiang* extract is an extract powder obtained by reflux extraction, concentration, and drying of *Zhang Liang Jiang* medicinal material using a 60%-80% ethanol aqueous solution, wherein the total gingerol and total curcumin compounds contained therein are not less than 15%; The Platycladus orientalis leaf extract is an extract powder obtained by reflux extraction, concentration, and drying of Platycladus orientalis leaf medicinal material using a 60%-80% ethanol aqueous solution, wherein the total flavonoid content is not less than 8%; The Polygonum multiflorum extract is an extract powder obtained by reflux extraction, concentration and drying of processed Polygonum multiflorum medicinal material using a 60%-80% ethanol aqueous solution, wherein the content of stilbene glycosides is not less than 5%.

[0007] Preferably, the galangal extract is prepared by the following method: The dried rhizomes of Ginger lanceolata are crushed to 20-40 mesh, and 8-12 times their weight of ethanol aqueous solution are added. The mixture is then refluxed at 80-90℃ for 2-3 times, each time for 1-2 hours. All extracts are combined and then filtered. The filtrate was concentrated under reduced pressure at 50-60℃ to an extract with a relative density of 1.10-1.20. The extract was placed in a vacuum drying oven and dried at 60-70℃ for 6-10 hours. The extract was then pulverized through a 100-mesh sieve to obtain the powder of Ginger Root Extract.

[0008] Preferably, the Platycladus orientalis leaf extract is prepared by the following method: Pulverize the dried arborvitae leaves to 20-40 mesh, add 8-12 times the weight of ethanol aqueous solution, and reflux extract at 80-90℃ 2-3 times, 1-2 hours each time. Combine all extracts and then filter. The filtrate was concentrated under reduced pressure at 50-60℃ to an extract with a relative density of 1.10-1.20. The extract was placed in a vacuum drying oven and dried at 60-70℃ for 6-10 hours. The extract was then pulverized through a 100-mesh sieve to obtain arborvitae leaf extract powder.

[0009] Preferably, the Polygonum multiflorum extract is prepared by the following method: Pulverize the processed Polygonum multiflorum slices to 20-40 mesh, add 8-12 times the weight of ethanol aqueous solution, and reflux extract at 80-90℃ 2-3 times, 1-2 hours each time. Combine all extracts and then filter. The filtrate was concentrated under reduced pressure at 50-60℃ to an extract with a relative density of 1.10-1.20. The extract was placed in a vacuum drying oven and dried at 60-70℃ for 6-10 hours. The extract was then pulverized through a 100-mesh sieve to obtain Polygonum multiflorum extract powder.

[0010] Preferably, the penetration enhancer is selected from at least one of amino ketone, isopropyl myristate, ethyl oleate, N-methylpyrrolidone, propylene glycol, and menthol.

[0011] Preferably, the composition further comprises 2-6 parts by weight of a hair regeneration functional agent, wherein the hair regeneration functional agent is selected from at least one of minoxidil, bimatoprost, finasteride, dutasteride, caffeine, adenosine, nicotinamide, and vitamin B6.

[0012] Preferably, the preparation of the composition includes: The extracts of Ginger sibiricum, Platycladus orientalis, Polygonum multiflorum, and a penetration enhancer were added to ethanol in sequence. The mixture was stirred at 200-500 r / min for 20-40 minutes at 20-30°C until all the solid powders were completely dissolved and a homogeneous, clear solution was formed. The solution was then filtered and filled to obtain the composition.

[0013] Preferably, the *Zingiber officinale* extract contains at least three of the following: hexahydrocurcumin, gingerone A, 1,2-dihydrocurcumin, (S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-tetradecanoate, β-sitosterol, stigmasterol, and arachidic acid, and the total content of the at least three active ingredients is not less than 5% of the total weight of the *Zingiber officinale* extract.

[0014] Preferably, the total content of hexahydrocurcumin, 1,2-dihydrocurcumin, β-sitosterol, stigmasterol, and arachidic acid in the *Ligusticum striatum* extract is 7-12% of the total weight of the extract, and the mass ratio of β-sitosterol to stigmasterol is 1:1-2:1.

[0015] Preferably, the composition is a topical preparation selected from at least one of tinctures, liniments, sprays, foams, gels, serums, creams, or hair growth solutions.

[0016] Compared with the prior art, the present invention provides a compound composition of Ginger indicum for improving androgenetic alopecia, which has the following beneficial effects: 1. In this invention, by limiting the content standards of total gingerol and total curcumin compounds in the extract of Zingiber officinale, total flavonoids in the extract of Platycladus orientalis leaves, and stilbene glycosides in the extract of Polygonum multiflorum, the quality and pharmacodynamic material basis of each core extract are guaranteed, thereby ensuring the stability of the composition's efficacy in improving androgenetic alopecia.

[0017] 2. In this invention, specific preparation methods are specified for extracts of Ginger sibiricum extract, Platycladus orientalis leaf extract, and Polygonum multiflorum extract, including process parameters such as particle size, solvent concentration, reflux extraction, and concentration and drying, to extract the active ingredients from the medicinal materials. Combined with penetration enhancers, various forms of topical preparations are obtained, ensuring the effectiveness of the composition and the convenience of clinical use.

[0018] 3. In this invention, by limiting the proportion of specific active ingredients such as hexahydrocurcumin and β-sitosterol in the extract of Ginger sibiricum and adding hair regeneration functional agents, the bioactivity of the composition and the stability of the content of the main active ingredients can be enhanced, thus ensuring the effect of the composition in promoting hair regeneration. Detailed Implementation

[0019] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0020] Example 1: A compound composition of galangal for improving androgenetic alopecia, made from the following raw materials in parts by weight: 20 parts of Ginger extract, 15 parts of Platycladus orientalis leaf extract, 10 parts of Polygonum multiflorum extract, 3 parts of penetration enhancer and 60 parts of ethanol; The extract of Ginger lanceolata is an extract powder obtained by reflux extraction, concentration and drying of Ginger lanceolata medicinal material using 60% ethanol aqueous solution, wherein the content of total gingerol and total curcumin compounds is not less than 15%; The Platycladus orientalis leaf extract is an extract powder obtained by reflux extraction, concentration, and drying of Platycladus orientalis leaf medicinal material using a 60% ethanol aqueous solution, wherein the total flavonoid content is not less than 8%; The extract of Polygonum multiflorum is an extract powder obtained by reflux extraction, concentration and drying of processed Polygonum multiflorum medicinal material using 60% ethanol aqueous solution, and the content of stilbene glycosides contained therein is not less than 5%.

[0021] The extract of Ginger buds was prepared by the following method: The dried rhizomes of Ginger lanceolata were crushed to 20 mesh, and 8 times their weight of ethanol aqueous solution were added. The mixture was refluxed twice at 80°C for 1 hour each time. All extracts were combined and then filtered. The filtrate was concentrated under reduced pressure at 50°C to an extract with a relative density of 1.10. The extract was placed in a vacuum drying oven and dried at 60°C for 6 hours. It was then pulverized through a 100-mesh sieve to obtain the powder of Ginger Root Extract.

[0022] The extract of Platycladus orientalis leaves was prepared by the following method: The dried arborvitae leaves were crushed to 20 mesh, and 8 times their weight of ethanol aqueous solution were added. The mixture was refluxed twice at 80°C for 1 hour each time. All extracts were combined and then filtered. The filtrate was concentrated under reduced pressure at 50°C to an extract with a relative density of 1.10. The extract was placed in a vacuum drying oven and dried at 60°C for 6 hours. It was then pulverized through a 100-mesh sieve to obtain arborvitae leaf extract powder.

[0023] Polygonum multiflorum extract is prepared by the following method: The processed Polygonum multiflorum slices were pulverized to 20 mesh, and 8 times their weight of ethanol aqueous solution were added. The mixture was refluxed twice at 80°C for 1 hour each time. All extracts were combined and then filtered. The filtrate was concentrated under reduced pressure at 50°C to an extract with a relative density of 1.10. The extract was placed in a vacuum drying oven and dried at 60°C for 6 hours. It was then pulverized through a 100-mesh sieve to obtain Polygonum multiflorum extract powder.

[0024] The penetration enhancer is aminoketone.

[0025] The composition also includes 2 parts by weight of a hair regeneration functional agent, namely minoxidil.

[0026] The preparation of the composition includes: The extracts of Ginger sibiricum, Platycladus orientalis, Polygonum multiflorum and a penetration enhancer were added to ethanol in sequence. The mixture was stirred at 200 r / min for 20 minutes at 20°C until all the solid powders were completely dissolved and a homogeneous, clear solution was formed. The solution was then filtered and filled to obtain the composition.

[0027] The extract of Ginger lanceolata contains hexahydrocurcumin, 1,2-dihydrocurcumin, β-sitosterol, and stigmasterol, and the total content of these active ingredients is not less than 5% of the total weight of the extract.

[0028] In the extract of Ginger lanceolata, the total content of hexahydrocurcumin, 1,2-dihydrocurcumin, β-sitosterol, stigmasterol and arachidic acid is 7% of the total weight of the extract, and the mass ratio of β-sitosterol to stigmasterol is 1:1.

[0029] The composition is a topical preparation, and the topical preparation is a tincture.

[0030] Example 2: A compound composition of galangal for improving androgenetic alopecia, made from the following raw materials in parts by weight: 28 parts of Ginger extract, 20 parts of Platycladus orientalis leaf extract, 15 parts of Polygonum multiflorum extract, 5 parts of penetration enhancer, and 70 parts of ethanol; The extract of Ginger lanceolata is an extract powder obtained by reflux extraction, concentration and drying of Ginger lanceolata medicinal material using 70% ethanol aqueous solution, wherein the content of total gingerol and total curcumin compounds is not less than 15%; The Platycladus orientalis leaf extract is an extract powder obtained by reflux extraction, concentration, and drying of Platycladus orientalis leaf medicinal material using a 70% ethanol aqueous solution, wherein the total flavonoid content is not less than 8%; The extract of Polygonum multiflorum is an extract powder obtained by reflux extraction, concentration and drying of processed Polygonum multiflorum medicinal material using 70% ethanol aqueous solution, and the content of stilbene glycosides contained therein is not less than 5%.

[0031] The extract of Ginger buds was prepared by the following method: The dried rhizomes of Ginger lanceolata were crushed to 30 mesh, and 10 times their weight of ethanol aqueous solution were added. The mixture was refluxed at 85°C for 3 times, 1.5 hours each time. All extracts were combined and then filtered. The filtrate was concentrated under reduced pressure at 55°C to an extract with a relative density of 1.15. The extract was placed in a vacuum drying oven and dried at 65°C for 8 hours. It was then pulverized through a 100-mesh sieve to obtain the powder of Ginger Root Extract.

[0032] The extract of Platycladus orientalis leaves was prepared by the following method: The dried arborvitae leaves were crushed to 30 mesh, and 10 times their weight of ethanol aqueous solution were added. The mixture was refluxed at 85°C for 3 times, 1.5 hours each time. All extracts were combined and then filtered. The filtrate was concentrated under reduced pressure at 55°C to an extract with a relative density of 1.15. The extract was placed in a vacuum drying oven and dried at 65°C for 8 hours. It was then pulverized through a 100-mesh sieve to obtain arborvitae leaf extract powder.

[0033] Polygonum multiflorum extract is prepared by the following method: The processed Polygonum multiflorum slices were pulverized to 30 mesh, and 10 times their weight of ethanol aqueous solution were added. The mixture was refluxed at 85°C for 3 times, 1.5 hours each time. All extracts were combined and then filtered. The filtrate was concentrated under reduced pressure at 55°C to an extract with a relative density of 1.15. The extract was placed in a vacuum drying oven and dried at 65°C for 8 hours. It was then pulverized through a 100-mesh sieve to obtain Polygonum multiflorum extract powder.

[0034] The penetration enhancer is isopropyl myristate.

[0035] The composition also includes 4 parts by weight of a hair regeneration functional agent, namely bimatoprost.

[0036] The preparation of the composition includes: The extracts of Ginger sibiricum, Platycladus orientalis, Polygonum multiflorum, and a penetration enhancer were added to ethanol in sequence. The mixture was stirred at 350 r / min for 30 minutes at 25°C until all the solid powders were completely dissolved and a homogeneous, clear solution was formed. The solution was then filtered and filled to obtain the composition.

[0037] The extract of Ginger lanceolata contains hexahydrocurcumin, 1,2-dihydrocurcumin, β-sitosterol, and stigmasterol, and the total content of these active ingredients is not less than 5% of the total weight of the extract.

[0038] The total content of hexahydrocurcumin, 1,2-dihydrocurcumin, β-sitosterol, stigmasterol, and arachidic acid in the extract of Ginger leonurus japonicus is 10% of the total weight of the extract, and the mass ratio of β-sitosterol to stigmasterol is 1.5:1.

[0039] The composition is a topical preparation, and the topical preparation is an essence.

[0040] Example 3: A compound composition of Ginger extract for improving androgenetic alopecia, made from the following raw materials in parts by weight: 35 parts of Ginger extract, 25 parts of Platycladus orientalis leaf extract, 20 parts of Polygonum multiflorum extract, 8 parts of penetration enhancer, and 80 parts of ethanol; The extract of Ginger lanceolata is an extract powder obtained by reflux extraction, concentration and drying of Ginger lanceolata medicinal material using 80% ethanol aqueous solution, wherein the content of total gingerol and total curcumin compounds is not less than 15%; The Platycladus orientalis leaf extract is an extract powder obtained by reflux extraction, concentration, and drying of Platycladus orientalis leaf medicinal material using 80% ethanol aqueous solution, wherein the total flavonoid content is not less than 8%; The extract of Polygonum multiflorum is an extract powder obtained by reflux extraction, concentration and drying of processed Polygonum multiflorum medicinal material using 80% ethanol aqueous solution, and the content of stilbene glycosides contained therein is not less than 5%.

[0041] The extract of Ginger buds was prepared by the following method: The dried rhizomes of Ginger lanceolata were crushed to 40 mesh, and 12 times their weight of ethanol aqueous solution were added. The mixture was refluxed at 90°C for 3 times, 2 hours each time. All extracts were combined and then filtered. The filtrate was concentrated under reduced pressure at 60°C to an extract with a relative density of 1.20. The extract was placed in a vacuum drying oven and dried at 70°C for 10 hours. It was then pulverized through a 100-mesh sieve to obtain the powder of Ginger Root Extract.

[0042] The extract of Platycladus orientalis leaves was prepared by the following method: The dried arborvitae leaves were crushed to 40 mesh, and 12 times their weight of ethanol aqueous solution were added. The mixture was refluxed at 90°C for 3 times, 2 hours each time. All extracts were combined and then filtered. The filtrate was concentrated under reduced pressure at 60°C to an extract with a relative density of 1.20. The extract was placed in a vacuum drying oven and dried at 70°C for 10 hours. It was then pulverized through a 100-mesh sieve to obtain arborvitae leaf extract powder.

[0043] Polygonum multiflorum extract is prepared by the following method: The processed Polygonum multiflorum slices were pulverized to 40 mesh, and 12 times the weight of ethanol aqueous solution was added. The mixture was refluxed at 90°C for 3 times, 2 hours each time. All extracts were combined and then filtered. The filtrate was concentrated under reduced pressure at 60°C to an extract with a relative density of 1.20. The extract was placed in a vacuum drying oven and dried at 70°C for 10 hours. It was then pulverized through a 100-mesh sieve to obtain Polygonum multiflorum extract powder.

[0044] The penetration enhancer is ethyl oleate.

[0045] The composition also includes 6 parts by weight of a hair regeneration functional agent, namely finasteride.

[0046] The preparation of the composition includes: The extracts of Ginger sibiricum, Platycladus orientalis, Polygonum multiflorum and a penetration enhancer were added to ethanol in sequence. The mixture was stirred at 500 r / min for 40 minutes at 30°C until all the solid powders were completely dissolved and a homogeneous, clear solution was formed. The solution was then filtered and filled to obtain the composition.

[0047] The extract of Ginger lanceolata contains hexahydrocurcumin, 1,2-dihydrocurcumin, β-sitosterol, and stigmasterol, and the total content of these active ingredients is not less than 5% of the total weight of the extract.

[0048] The total content of hexahydrocurcumin, 1,2-dihydrocurcumin, β-sitosterol, stigmasterol, and arachidic acid in the extract of Ginger spp. is 12% of the total weight of the extract, and the mass ratio of β-sitosterol to stigmasterol is 2:1.

[0049] The composition is a topical preparation, and the topical preparation is a cream.

[0050] Comparative Example 1: The difference between this comparative example and Example 1 is that this comparative example did not add Ginger extract when preparing the composition, that is, it was composed only of Platycladus orientalis leaf extract, Polygonum multiflorum extract, penetration enhancer and ethanol in proportion.

[0051] Comparative Example 2 differs from Example 1 in that: no penetration enhancer was added when preparing the composition in this comparative example, that is, only the extracts of Ginger sibiricum, Platycladus orientalis, Polygonum multiflorum and ethanol were mixed in proportion.

[0052] Comparative Example 3 differs from Example 1 in that: no optional hair regeneration functional agent was added when preparing the composition in this comparative example, i.e., the basic formula consists only of Ginger extract, Platycladus orientalis leaf extract, Polygonum multiflorum extract, penetration enhancer and ethanol.

[0053] Comparative Example 4 differs from Example 1 in that: in this comparative example, the extracts of Ginger sibiricum, Platycladus orientalis, and Polygonum multiflorum were directly added to ethanol without adding a penetration enhancer, and the mixture was left to stand at room temperature instead of being stirred. The resulting mixture was a heterogeneous suspension rather than a clear solution.

[0054] The performance of the Zhang Liangjiang compound compositions prepared in Examples 1-3 and Comparative Examples 1-4 for improving androgenetic alopecia was tested. The test items and test methods are as follows: 5α-Reductase Inhibition Rate Test: The inhibition rate of each sample on 5α-reductase activity was determined by in vitro enzyme-linked immunosorbent assay (ELISA) to assess its potential to block the conversion of testosterone to dihydrotestosterone.

[0055] Hair follicle outer root sheath cell proliferation assay: Using human hair follicle outer root sheath cell lines, the proliferation activity of cells after sample treatment was detected by CCK-8 assay to evaluate their ability to directly promote hair follicle cell growth.

[0056] Evaluation of hair regrowth effect in animal models: Using androgenetic alopecia model mice, samples were applied periodically, and the percentage of hair follicles in skin biopsy tissues was observed and compared after the experimental period.

[0057] Stability study: The samples were placed at 40℃ and 75% relative humidity for 3 months, and the changes in the content of the main active ingredients, namely total gingerol, total flavonoids and stilbene glycosides, were detected.

[0058] The test data for the compositions prepared in Examples 1-3 and Comparative Examples 1-4 are recorded in the table below: By comparing and analyzing the data in the table, it can be seen that the Zhang Liang Jiang compound composition prepared using the complete formula and process in Examples 1-3 has significantly better performance than the compositions prepared in Comparative Examples 1-4. This indicates that in this invention, by limiting the content standards of total gingerol and total curcumin compounds in Zhang Liang Jiang extract, total flavonoids in Platycladus orientalis leaf extract, and stilbene glycosides in Polygonum multiflorum extract, the quality and pharmacodynamic material basis of each core extract are guaranteed, thereby ensuring the stability of the composition's efficacy in improving androgenetic alopecia. Furthermore, by controlling the content standards of Zhang Liang Jiang extract, Platycladus orientalis leaf extract, and Polygonum multiflorum extract... The formulation specifies detailed preparation methods, including process parameters such as particle size, solvent concentration, reflux extraction, and concentration and drying, to extract active ingredients from medicinal materials. Combined with penetration enhancers, various forms of topical preparations are prepared, ensuring the effectiveness and convenience of clinical use of the composition. Based on the basic compound composition, by limiting the proportion of specific active ingredients such as hexahydrocurcumin and β-sitosterol in the extract of Gynostemma pentaphyllum, and by adding hair regeneration functional agents, the bioactivity of the composition and the stability of the content of the main active ingredients can be enhanced, ensuring the effect of the composition in promoting hair regeneration.

[0059] By comparing and analyzing the relevant data in the table, it can be seen that the Zhang Liangjiang compound composition provided by the present invention has good 5α-reductase inhibition effect, hair follicle cell proliferation promoting activity and formulation stability.

[0060] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0061] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A compound composition of galangal for improving androgenetic alopecia, characterized in that: Made from the following parts by weight of raw materials: 20-35 parts of Ginger extract, 15-25 parts of Platycladus orientalis leaf extract, 10-20 parts of Polygonum multiflorum extract, 3-8 parts of penetration enhancer, and 60-80 parts of ethanol; The *Zhang Liang Jiang* extract is an extract powder obtained by reflux extraction, concentration, and drying of *Zhang Liang Jiang* medicinal material using a 60%-80% ethanol aqueous solution, wherein the total gingerol and total curcumin compounds contained therein are not less than 15%; The Platycladus orientalis leaf extract is an extract powder obtained by reflux extraction, concentration, and drying of Platycladus orientalis leaf medicinal material using a 60%-80% ethanol aqueous solution, wherein the total flavonoid content is not less than 8%; The Polygonum multiflorum extract is an extract powder obtained by reflux extraction, concentration and drying of processed Polygonum multiflorum medicinal material using a 60%-80% ethanol aqueous solution, wherein the content of stilbene glycosides is not less than 5%.

2. The Zhang Liangjiang compound composition for improving androgenetic alopecia according to claim 1, characterized in that: The galangal extract was prepared by the following method: The dried rhizomes of Ginger lanceolata are crushed to 20-40 mesh, and 8-12 times their weight of ethanol aqueous solution are added. The mixture is then refluxed at 80-90℃ for 2-3 times, each time for 1-2 hours. All extracts are combined and then filtered. The filtrate was concentrated under reduced pressure at 50-60℃ to an extract with a relative density of 1.10-1.

20. The extract was placed in a vacuum drying oven and dried at 60-70℃ for 6-10 hours. The extract was then pulverized through a 100-mesh sieve to obtain the powder of Ginger Root Extract.

3. The Zhang Liangjiang compound composition for improving androgenetic alopecia according to claim 1, characterized in that: The Platycladus orientalis leaf extract was prepared by the following method: Pulverize the dried arborvitae leaves to 20-40 mesh, add 8-12 times the weight of ethanol aqueous solution, and reflux extract at 80-90℃ 2-3 times, 1-2 hours each time. Combine all extracts and then filter. The filtrate was concentrated under reduced pressure at 50-60℃ to an extract with a relative density of 1.10-1.

20. The extract was placed in a vacuum drying oven and dried at 60-70℃ for 6-10 hours. The extract was then pulverized through a 100-mesh sieve to obtain arborvitae leaf extract powder.

4. The Zhang Liangjiang compound composition for improving androgenetic alopecia according to claim 1, characterized in that: The Polygonum multiflorum extract was prepared by the following method: Pulverize the processed Polygonum multiflorum slices to 20-40 mesh, add 8-12 times the weight of ethanol aqueous solution, and reflux extract at 80-90℃ 2-3 times, 1-2 hours each time. Combine all extracts and then filter. The filtrate was concentrated under reduced pressure at 50-60℃ to an extract with a relative density of 1.10-1.

20. The extract was placed in a vacuum drying oven and dried at 60-70℃ for 6-10 hours. The extract was then pulverized through a 100-mesh sieve to obtain Polygonum multiflorum extract powder.

5. The Zhang Liangjiang compound composition for improving androgenetic alopecia according to claim 1, characterized in that: The penetration enhancer is selected from at least one of amino ketone, isopropyl myristate, ethyl oleate, N-methylpyrrolidone, propylene glycol, and menthol.

6. The Zhang Liangjiang compound composition for improving androgenetic alopecia according to claim 1, characterized in that: The composition further includes 2-6 parts by weight of a hair regeneration functional agent, wherein the hair regeneration functional agent is selected from at least one of minoxidil, bimatoprost, finasteride, dutasteride, caffeine, adenosine, nicotinamide, and vitamin B6.

7. The Zhang Liangjiang compound composition for improving androgenetic alopecia according to claim 1, characterized in that: The preparation of the composition includes: The extracts of Ginger sibiricum, Platycladus orientalis, Polygonum multiflorum, and a penetration enhancer were added to ethanol in sequence. The mixture was stirred at 200-500 r / min for 20-40 minutes at 20-30°C until all the solid powders were completely dissolved and a homogeneous, clear solution was formed. The solution was then filtered and filled to obtain the composition.

8. The Zhang Liangjiang compound composition for improving androgenetic alopecia according to claim 1, characterized in that: The *Zingiber officinale* extract contains at least three of the following: hexahydrocurcumin, gingerone A, 1,2-dihydrocurcumin, (S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-tetradecanoate, β-sitosterol, stigmasterol, and arachidic acid, and the total content of the at least three active ingredients is not less than 5% of the total weight of the *Zingiber officinale* extract.

9. A compound composition of galangal for improving androgenetic alopecia according to claim 8, characterized in that: The total content of hexahydrocurcumin, 1,2-dihydrocurcumin, β-sitosterol, stigmasterol, and arachidic acid in the *Ligusticum striatum* extract is 7-12% of the total weight of the extract, and the mass ratio of β-sitosterol to stigmasterol is 1:1-2:

1.

10. A compound composition of galangal for improving androgenetic alopecia according to claim 1, characterized in that: The composition is a topical preparation selected from at least one of tinctures, liniments, sprays, foams, gels, serums, creams, or hair growth solutions.

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