Self-adhesive bacteriostatic sponge bandage and preparation method thereof

Abstract

The application belongs to the technical field of biomedicine and specifically relates to a self-adhesive bacteriostatic sponge bandage and a preparation method thereof. The self-adhesive bacteriostatic sponge bandage comprises a bacteriostatic sponge, a pressure-sensitive hot melt adhesive and release paper. The raw material of the bacteriostatic sponge comprises, in mass parts, 100 parts of polyether polyol, 1-5 parts of modified small-molecule polyol A, 3-6 parts of modified nano zinc oxide, 45-60 parts of isocyanate, 0.1-2 parts of silicone oil, 0.1-1 part of a catalyst and 2-5 parts of a foaming agent. The modified small-molecule polyol A is prepared by the reaction of small-molecule polyol A, acid anhydride A and cardanol glycidyl ether. The self-adhesive bacteriostatic sponge bandage provided by the application has excellent bacteriostatic performance, air permeability and mechanical properties.

Description

Technical Field

[0001] This invention belongs to the field of biomedical technology, specifically relating to a self-adhesive antibacterial sponge bandage and its preparation method. Background Technology

[0002] Sponge bandages are soft, comfortable, conforming, absorbent, and breathable. They can be used not only in medical fields such as surgery and wound dressing, but also in daily care and sports protection.

[0003] Currently, the main type of sponge bandage on the market is polyurethane sponge bandage, which can be divided into two categories: non-adhesive and self-adhesive. Non-adhesive sponge bandages require pressure to hold them in place and are prone to slipping and unraveling after application. Self-adhesive bandages, on the other hand, are easy to use and require no other object for fixation, leading to their increasingly wider applications. For example, Chinese patent CN101219236B discloses a self-adhesive sponge bandage comprising a polyurethane sponge film and pressure-sensitive hot melt adhesive, meeting the following conditions: ① The density of the polyurethane sponge film is 20-50 kg / m³. 3 The thickness is 0.3-1.0 mm; ② The pressure-sensitive hot melt adhesive is coated on a polyurethane sponge film, and the coating amount of the pressure-sensitive hot melt adhesive is 8-40 g / m. 2 The pressure-sensitive hot melt adhesive is a natural latex pressure-sensitive hot melt adhesive, and its components have the following weight ratio: 100 parts natural latex, 5-40 parts liquid paraffin, 1-10 parts oleic acid, 0.5-5 parts 2,6-di-tert-butyl-4-methylphenol, 0.5-2 parts potassium sorbate, and 2-10 parts acrylate. For example, Chinese Patent Publication No. CN104758975A discloses a sponge self-adhesive bandage, comprising a polyurethane sponge film, a self-adhesive pressure-sensitive hot melt adhesive without antigenic proteins, and a release paper. Both sides of the polyurethane sponge film are coated with the self-adhesive pressure-sensitive hot melt adhesive without antigenic proteins. The release paper is laminated to one side of the polyurethane sponge film coated with the self-adhesive pressure-sensitive hot melt adhesive without antigenic proteins. The density of the polyurethane sponge film is 20-50 kg / m³. 3 The thickness of the polyurethane foam film is 0.6-2 mm; the coating amount of the self-adhesive pressure-sensitive hot melt adhesive without antigen proteins is 10-50 g / m². 2 The self-adhesive pressure-sensitive hot melt adhesive without antigen proteins comprises, by weight, 200 parts of a non-latex latex without antigen proteins, 20-40 parts of white oil, 5-10 parts of emulsifier, and 5-10 parts of sodium benzoate; the non-latex latex without antigen proteins is one or more of polyvinyl acetate latex, polyacrylate latex, and polyurethane latex.

[0004] However, the self-adhesive sponge bandages described above do not possess antibacterial properties, thus requiring further improvement. Furthermore, the quality of existing self-adhesive sponge bandages varies considerably, failing to achieve a balance between breathability and mechanical properties. Therefore, this invention is proposed. Summary of the Invention

[0005] The purpose of this invention is to provide a self-adhesive antibacterial sponge bandage and its preparation method. The self-adhesive antibacterial sponge bandage provided by this invention has excellent antibacterial properties, breathability, and mechanical properties.

[0006] To achieve the above objectives, the present invention provides the following technical solution:

[0007] The first aspect of this invention provides a self-adhesive antibacterial sponge bandage, comprising an antibacterial sponge, a pressure-sensitive hot melt adhesive, and a release paper; the raw materials of the antibacterial sponge, by weight, include: 100 parts of polyether polyol, 1-5 parts of modified small molecule polyol A1, 3-6 parts of modified nano zinc oxide, 45-60 parts of isocyanate, 0.1-2 parts of silicone oil, 0.1-1 parts of catalyst, and 2-5 parts of foaming agent.

[0008] According to a preferred embodiment of the present invention, the self-adhesive antibacterial sponge bandage has an elongation at break >150%, a tensile strength >260 kPa, and an air permeability >330 mL / cm². 2 / min, Escherichia coli inhibition rate >99%, Staphylococcus aureus >99%.

[0009] According to a preferred embodiment of the present invention, the polyether polyol is selected from at least one of polytetramethylene ether glycol and polytrimethylene ether glycol.

[0010] According to a preferred embodiment of the present invention, the modified small molecule polyol A is prepared by reacting small molecule polyol A, acid anhydride A and cashew phenol glycidyl ether.

[0011] According to a preferred embodiment of the present invention, the small molecule polyol A is selected from at least one of 2,2-bis(hydroxymethyl-1,3-propane) and bis(trimethylolpropane).

[0012] According to a preferred embodiment of the present invention, the acid anhydride A is selected from at least one of succinic anhydride, glutaric anhydride, maleic anhydride and itaconic anhydride.

[0013] According to a preferred embodiment of the present invention, the structural formula of the cashew phenol glycidyl ether is as follows: .

[0014] According to a preferred embodiment of the present invention, the modified small molecule polyol A is prepared by mixing small molecule polyol A, acid anhydride A and cashew phenol glycidyl ether, adding tetraethylammonium bromide, heating the mixture until the acid value is ≤2mgKOH / g, and then cooling it down to obtain the product.

[0015] According to a preferred embodiment of the present invention, the molar ratio of the small molecule polyol A, acid anhydride A and cashew phenol glycidyl ether is 1:2-3:2-3.

[0016] According to a preferred embodiment of the present invention, the amount of tetraethylammonium bromide added is 0.5-1.5% of the total mass of acid anhydride A and cashew phenol glycidyl ether.

[0017] According to a preferred embodiment of the present invention, the temperature of the heating reaction is 90-110°C.

[0018] The modified small molecule polyol A provided by this invention utilizes the ring-opening reaction between the hydroxyl groups in the small molecule polyol A and the acid anhydride A to generate carboxyl groups. The ring-opening reaction between the carboxyl groups and the epoxy groups in cashew phenol glycidyl ether yields a branched modified small molecule polyol A containing a long chain of cashew phenol, which can participate in the reaction with isocyanate, significantly improving the mechanical properties of sponge bandages and exhibiting high air permeability.

[0019] According to a preferred embodiment of the present invention, the modified nano zinc oxide is prepared by coating nano zinc oxide with modified small molecule polyol B.

[0020] According to a preferred embodiment of the present invention, the particle size of the nano zinc oxide is 10-30 nm.

[0021] According to a preferred embodiment of the present invention, the modified small molecule polyol B is prepared by reacting small molecule polyol B, acid anhydride B and glycidyltrimethylammonium chloride.

[0022] According to a preferred embodiment of the present invention, the small molecule polyol B is selected from at least one of 2,2-bis(hydroxymethyl)-1,3-propanediol and bis(trimethylolpropane).

[0023] According to a preferred embodiment of the present invention, the anhydride B is selected from at least one of succinic anhydride, glutaric anhydride, maleic anhydride and itaconic anhydride.

[0024] According to a preferred embodiment of the present invention, the modified nano zinc oxide is prepared by mixing nano zinc oxide, small molecule polyol B, acid anhydride B, glycidyltrimethylammonium chloride and acetone, adding tetraethylammonium bromide, heating and stirring the reaction until the acid value is ≤2mgKOH / g, cooling, filtering, and rotary evaporation to obtain the product.

[0025] According to a preferred embodiment of the present invention, the molar ratio of the small molecule polyol B, acid anhydride B and glycidyltrimethylammonium chloride is 1:2-3:2-3.

[0026] According to a preferred embodiment of the present invention, the mass ratio of the nano zinc oxide, the small molecule polyol B and acetone is 1.5-2:1:10-15.

[0027] According to a preferred embodiment of the present invention, the amount of tetraethylammonium bromide added is 0.5-1.5% of the total mass of acid anhydride B and glycidyltrimethylammonium chloride.

[0028] Nano zinc oxide has good antibacterial properties; however, it is difficult to disperse evenly in polyurethane foam, which not only fails to fully exert its antibacterial properties but also affects the mechanical properties of the polyurethane foam, resulting in a decline in the mechanical properties of the foam bandage.

[0029] To address the aforementioned technical problems, this invention employs a modified small-molecule polyol B obtained by reacting small-molecule polyol B, acid anhydride B, and glycidyltrimethylammonium chloride to coat the surface of nano-zinc oxide. The modified small-molecule polyol B on the surface of the nano-zinc oxide contains a quaternary ammonium salt structure, which can work together with zinc oxide to exert antibacterial effects. Simultaneously, the modified small-molecule polyol B can participate in the reaction with isocyanate, which not only ensures that the nano-zinc oxide is uniformly dispersed in the polyurethane sponge to exert its antibacterial effect, but also improves the uniformity of the foam structure. Therefore, it not only improves the antibacterial performance of the sponge bandage, but also enhances its mechanical properties and air permeability.

[0030] According to a preferred embodiment of the present invention, the isocyanate is selected from at least one of diphenylmethane diisocyanate, toluene diisocyanate, hexamethylene diisocyanate, isoflurone diisocyanate, hydrogenated diphenylmethylene diisocyanate, and methylene diphenyl diisocyanate.

[0031] According to a preferred embodiment of the present invention, the catalyst is selected from at least one of amine catalysts and organotin catalysts.

[0032] According to a preferred embodiment of the present invention, the amine catalyst is selected from at least one of triethylenediamine, diphenylamine, dimethylcyclohexylamine, N,N-dimethylacetamide and N,N-dimethylpropionamide.

[0033] According to a preferred embodiment of the present invention, the organotin catalyst is selected from at least one of stannous octoate, dibutyltin dilaurate, dibutyltin diacetate, and di(dodecyl sulfide)dibutyltin.

[0034] According to a preferred embodiment of the present invention, the foaming agent is water.

[0035] According to a preferred embodiment of the present invention, the method for preparing the antibacterial sponge includes the following steps: mixing polyether polyol, modified small molecule polyol A, catalyst, silicone oil and foaming agent, adding modified nano zinc oxide and mixing, and finally adding isocyanate, foaming, curing and aging to obtain the product.

[0036] According to a preferred embodiment of the present invention, the foaming temperature is 50-55°C and the time is 20-30 minutes.

[0037] According to a preferred embodiment of the present invention, the curing temperature is 35-40°C and the time is 2-3 hours.

[0038] According to a preferred embodiment of the present invention, the curing temperature is 25°C and the time is 20-24 hours.

[0039] The second aspect of the present invention provides a method for preparing a self-adhesive antibacterial sponge bandage, comprising the following steps: coating a pressure-sensitive hot melt adhesive onto an antibacterial sponge, then covering it with release paper, applying pressure to bond the bandage, and then winding it up to obtain the bandage.

[0040] According to a preferred embodiment of the present invention, the coating amount of the pressure-sensitive hot melt adhesive is 10-50 g / m². 2 .

[0041] According to a preferred embodiment of the present invention, the thickness of the antibacterial sponge is 0.5-3 mm.

[0042] According to a preferred embodiment of the present invention, the density of the antibacterial sponge is 20-50 kg / m³. 3 .

[0043] Compared with the prior art, the advantages and beneficial effects of the present invention are as follows:

[0044] 1. The modified small molecule polyol A provided by the present invention utilizes the ring-opening reaction between the hydroxyl group in the small molecule polyol A and the acid anhydride A to generate a carboxyl group. The ring-opening reaction between the carboxyl group and the epoxy group in the cashew phenol glycidyl ether yields a branched modified small molecule polyol A containing a long chain of cashew phenol, which can participate in the reaction with isocyanate, significantly improving the mechanical properties of the sponge bandage and exhibiting high air permeability.

[0045] 2. This invention uses a modified small molecule polyol B obtained by reacting small molecule polyol B, acid anhydride B, and glycidyltrimethylammonium chloride to coat the surface of nano zinc oxide. The modified small molecule polyol B on the surface of nano zinc oxide contains a quaternary ammonium salt structure, which can work together with zinc oxide to exert antibacterial effects. At the same time, the modified small molecule polyol B can participate in the reaction with isocyanate, which not only makes the nano zinc oxide uniformly dispersed in the polyurethane sponge to exert its antibacterial effect, but also improves the uniformity of the foam structure. Therefore, it not only improves the antibacterial performance of the sponge bandage, but also improves its mechanical properties and air permeability. Detailed Implementation

[0046] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0047] Preparation Example 1: Modified Small Molecule Polyol A

[0048] Mix small molecule polyol A, acid anhydride A and cashew phenol glycidyl ether, add tetraethylammonium bromide, heat to 100℃ and react until the acid value is ≤2mgKOH / g, then cool to obtain the final product.

[0049] The small molecule polyol A is 2,2-bis(hydroxymethyl)-1,3-propanediol.

[0050] The acid anhydride A is succinic anhydride.

[0051] The structural formula of the cashew phenol glycidyl ether is: .

[0052] The molar ratio of the small molecule polyol A, acid anhydride A, and cashew phenol glycidyl ether is 1:2:2.

[0053] The amount of tetraethylammonium bromide added is 1% of the total mass of acid anhydride A and cashew phenol glycidyl ether.

[0054] Preparation Example 2: Modified Small Molecule Polyol C

[0055] The small molecule polyol C, acid anhydride C and cashew phenol glycidyl ether are mixed, tetraethylammonium bromide is added, the mixture is heated to 100℃ and reacted until the acid value is ≤2mgKOH / g, and then the mixture is cooled to obtain the final product.

[0056] The small molecule polyol C is propylene glycol.

[0057] The acid anhydride C is succinic anhydride.

[0058] The structural formula of the cashew phenol glycidyl ether is: .

[0059] The molar ratio of the small molecule polyol C, acid anhydride C, and cashew phenol glycidyl ether is 1:2:2.

[0060] The amount of tetraethylammonium bromide added is 1% of the total mass of acid anhydride C and cashew phenol glycidyl ether.

[0061] Preparation Example 3: Modified Small Molecule Polyol D

[0062] The mixture of small molecule polyol D, acid anhydride D and epichlorohydrin is added, tetraethylammonium bromide is added, the mixture is heated to 100℃ and reacted until the acid value is ≤2mgKOH / g, and then the temperature is lowered to obtain the final product.

[0063] The small molecule polyol D is 2,2-bis(hydroxymethyl)-1,3-propanediol.

[0064] The acid anhydride D is succinic anhydride.

[0065] The molar ratio of the small molecule polyol D, acid anhydride D, and epichlorohydrin is 1:2:2.

[0066] The amount of tetraethylammonium bromide added is 1% of the total mass of acid anhydride D and epichlorohydrin.

[0067] Preparation Example 4: Modified Nano Zinc Oxide

[0068] Nano zinc oxide, small molecule polyol B, acid anhydride B, glycidyltrimethylammonium chloride and acetone are mixed, tetraethylammonium bromide is added, the mixture is heated and stirred until the acid value is ≤2mgKOH / g, then cooled, filtered and rotary evaporated to obtain the final product.

[0069] The nano zinc oxide has a particle size of 20 nm.

[0070] The small molecule polyol B is 2,2-dihydroxymethyl-1,3-propanediol.

[0071] The acid anhydride B is succinic anhydride.

[0072] The molar ratio of the small molecule polyol B, acid anhydride B, and glycidyltrimethylammonium chloride is 1:2:2.

[0073] The mass ratio of the nano zinc oxide, small molecule polyol B, and acetone is 1.8:1:12.

[0074] The amount of tetraethylammonium bromide added is 1% of the total mass of acid anhydride B and glycidyltrimethylammonium chloride.

[0075] Preparation Example 5: Modified Nano Zinc Oxide

[0076] Nano zinc oxide, small molecule polyol E, acid anhydride E, glycidyltrimethylammonium chloride and acetone are mixed, tetraethylammonium bromide is added, the mixture is heated and stirred until the acid value is ≤2mgKOH / g, then cooled, filtered and rotary evaporated to obtain the final product.

[0077] The nano zinc oxide has a particle size of 20 nm.

[0078] The small molecule polyol E is propylene glycol.

[0079] The acid anhydride E is succinic anhydride.

[0080] The molar ratio of the small molecule polyol E, acid anhydride E, and glycidyltrimethylammonium chloride is 1:2:2.

[0081] The mass ratio of the nano zinc oxide, small molecule polyol E, and acetone is 1.8:1:12.

[0082] The amount of tetraethylammonium bromide added is 1% of the total mass of acid anhydride E and glycidyltrimethylammonium chloride.

[0083] Preparation Example 6: Modified Nano Zinc Oxide

[0084] Nano zinc oxide, small molecule polyol F, acid anhydride F, epichlorohydrin and acetone are mixed, tetraethylammonium bromide is added, the mixture is heated and stirred until the acid value is ≤2mgKOH / g, then cooled, filtered and rotary evaporated to obtain the final product.

[0085] The nano zinc oxide has a particle size of 20 nm.

[0086] The small molecule polyol F is 2,2-bis(hydroxymethyl)-1,3-propanediol.

[0087] The acid anhydride F is succinic anhydride.

[0088] The molar ratio of the small molecule polyol F, acid anhydride F, and epichlorohydrin is 1:2:2.

[0089] The mass ratio of the nano zinc oxide, small molecule polyol F, and acetone is 1.8:1:12.

[0090] The amount of tetraethylammonium bromide added is 1% of the total mass of acid anhydride F and epichlorohydrin.

[0091] Preparation Example 7: Modified Nano Zinc Oxide

[0092] The nano zinc oxide, dispersant, and polyether polyol are mixed and stirred until homogeneous to obtain the final product.

[0093] The dispersant is propylene glycol block polyether-L64 (chemical composition: polyoxyethylene and polyoxypropylene block polymer, average molecular weight of 2900), Shanghai Lianji Chemical Co., Ltd.

[0094] The hydroxyl value of the polyether polyol is 31-35 mgKOH / g, manufactured by Changhua Chemical Technology Co., Ltd., model number: CHK-350D.

[0095] The nano zinc oxide has a particle size of 20 nm.

[0096] The mass ratio of the nano zinc oxide, dispersant, and polyether polyol is 2:1:1.

[0097] Example 1

[0098] A self-adhesive antibacterial sponge bandage includes an antibacterial sponge, pressure-sensitive hot melt adhesive, and release paper; the raw materials of the antibacterial sponge, by weight, include: 100 parts of polyether polyol, 2 parts of modified small molecule polyol A, 3 parts of modified nano zinc oxide of Preparation Example 4, 46 parts of isocyanate, 0.6 parts of silicone oil, 0.2 parts of catalyst, and 2 parts of foaming agent.

[0099] The polyether polyol is polytrimethylene ether glycol, with a hydroxyl value of 53.5-59.1 mgKOH / g, manufactured by Guangzhou Daxiong Chemical Co., Ltd., model: H2000.

[0100] The isocyanate is selected from isocyanates, specifically toluene diisocyanate.

[0101] The catalyst is dibutyltin dilaurate.

[0102] The foaming agent is water.

[0103] The method for preparing the antibacterial sponge includes the following steps: mixing polyether polyol, modified small molecule polyol A, catalyst, silicone oil and foaming agent, adding modified nano zinc oxide and mixing, and finally adding isocyanate, foaming at 50°C for 30 min, curing at 40°C for 2 h, and aging at 25°C for 24 h to obtain the final product.

[0104] The preparation method of the above-mentioned self-adhesive antibacterial sponge bandage includes the following steps: coating the antibacterial sponge with pressure-sensitive hot melt adhesive, covering it with release paper, pressure bonding, and winding it up.

[0105] The coating amount of the pressure-sensitive hot melt adhesive is 20 g / m². 2 .

[0106] The antibacterial sponge has a thickness of 2 mm.

[0107] The density of the antibacterial sponge is 35.3 kg / m³. 3 .

[0108] Example 2

[0109] A self-adhesive antibacterial sponge bandage includes an antibacterial sponge, a pressure-sensitive hot melt adhesive, and a release paper; the raw materials of the antibacterial sponge, by weight, include: 100 parts of polyether polyol, 3 parts of modified small molecule polyol A, 5 parts of modified nano zinc oxide of Preparation Example 4, 49 parts of isocyanate, 1.2 parts of silicone oil, 0.3 parts of catalyst, and 3 parts of foaming agent.

[0110] The polyether polyol is polytrimethylene ether diol with a hydroxyl value of 53.5-59.1 mgKOH / g, manufactured by Guangzhou Daxiong Chemical Co., Ltd., model number: H2000.

[0111] The isocyanate is selected from isocyanates, specifically toluene diisocyanate.

[0112] The catalyst is dibutyltin dilaurate.

[0113] The foaming agent is water.

[0114] The method for preparing the antibacterial sponge includes the following steps: mixing polyether polyol, modified small molecule polyol A, catalyst, silicone oil and foaming agent, adding modified nano zinc oxide and mixing, and finally adding isocyanate, foaming at 50°C for 30 min, curing at 40°C for 2 h, and aging at 25°C for 24 h to obtain the final product.

[0115] The preparation method of the above-mentioned self-adhesive antibacterial sponge bandage includes the following steps: coating the antibacterial sponge with pressure-sensitive hot melt adhesive, covering it with release paper, pressing and laminating, and then winding it up.

[0116] The coating amount of the pressure-sensitive hot melt adhesive is 20 g / m². 2 .

[0117] The antibacterial sponge has a thickness of 2 mm.

[0118] The density of the antibacterial sponge is 33.5 kg / m³. 3 .

[0119] Example 3

[0120] A self-adhesive antibacterial sponge bandage includes an antibacterial sponge, pressure-sensitive hot melt adhesive, and release paper; the raw materials of the antibacterial sponge, by weight, include: 100 parts of polyether polyol, 5 parts of modified small molecule polyol A, 6 parts of modified nano zinc oxide of Preparation Example 4, 55 parts of isocyanate, 1.5 parts of silicone oil, 0.4 parts of catalyst, and 4 parts of foaming agent.

[0121] The polyether polyol is polytrimethylene ether diol with a hydroxyl value of 53.5-59.1 mgKOH / g, manufactured by Guangzhou Daxiong Chemical Co., Ltd., model number: H2000.

[0122] The isocyanate is selected from isocyanates, specifically toluene diisocyanate.

[0123] The catalyst is dibutyltin dilaurate.

[0124] The foaming agent is water.

[0125] The method for preparing the antibacterial sponge includes the following steps: mixing polyether polyol, modified small molecule polyol A, catalyst, silicone oil and foaming agent, adding modified nano zinc oxide and mixing, and finally adding isocyanate, foaming at 50°C for 30 min, curing at 40°C for 2 h, and aging at 25°C for 24 h to obtain the final product.

[0126] The preparation method of the above-mentioned self-adhesive antibacterial sponge bandage includes the following steps: coating the antibacterial sponge with pressure-sensitive hot melt adhesive, covering it with release paper, pressing and laminating, and then winding it up.

[0127] The coating amount of the pressure-sensitive hot melt adhesive is 20 g / m². 2 .

[0128] The antibacterial sponge has a thickness of 2 mm.

[0129] The density of the antibacterial sponge is 32.7 kg / m³. 3 .

[0130] Comparative Example 1

[0131] The difference between this comparative example and Example 3 is that the modified small molecule polyol A is replaced with diethanolamine; all other aspects are the same.

[0132] Comparative Example 2

[0133] The difference between this comparative example and Example 3 is that modified small molecule polyol A is replaced with modified small molecule polyol C; all other aspects are the same.

[0134] Comparative Example 3

[0135] The difference between this comparative example and Example 3 is that modified small molecule polyol A is replaced with modified small molecule polyol D; all other aspects are the same.

[0136] Comparative Example 4

[0137] The difference between this comparative example and Example 3 is that the modified nano zinc oxide in Preparation Example 4 is replaced with the modified nano zinc oxide in Preparation Example 5; all other aspects are the same.

[0138] Comparative Example 5

[0139] The difference between this comparative example and Example 3 is that the modified nano zinc oxide in Preparation Example 4 is replaced with the modified nano zinc oxide in Preparation Example 6; all other aspects are the same.

[0140] Comparative Example 6

[0141] The difference between this comparative example and Example 3 is that the modified nano zinc oxide in Preparation Example 4 is replaced with the modified nano zinc oxide in Preparation Example 7; all other aspects are the same.

[0142] Comparative Example 7

[0143] The difference between this comparative example and Example 3 is that the modified nano zinc oxide in Preparation Example 4 is replaced with an antibacterial small molecule polyol. The preparation method of the antibacterial small molecule polyol is as follows: small molecule polyol B, acid anhydride B, and glycidyltrimethylammonium chloride are mixed, tetraethylammonium bromide is added, the mixture is heated and stirred until the acid value is ≤2mgKOH / g, then cooled, filtered, and rotary evaporated to obtain the product.

[0144] The small molecule polyol B is 2,2-dihydroxymethyl-1,3-propanediol.

[0145] The acid anhydride B is succinic anhydride.

[0146] The molar ratio of the small molecule polyol B, acid anhydride B, and glycidyltrimethylammonium chloride is 1:2:2.

[0147] The amount of tetraethylammonium bromide added is 1% of the total mass of acid anhydride B and glycidyltrimethylammonium chloride; all other amounts are the same.

[0148] Performance testing

[0149] The performance tests of the self-adhesive antibacterial sponge bandages prepared in Examples 1-3 and Comparative Examples 1-7 are shown in Tables 1 and 2 below.

[0150] Table 1 Performance Tests and Results

[0151]

[0152] Table 2 Performance Tests and Results

[0153]

[0154] As shown in Tables 1 and 2, the antibacterial sponge uses specific modified small molecule polyols and modified nano zinc oxide during the preparation process, which not only enables the bandage to have an antibacterial rate of over 99%, but also has excellent mechanical properties and breathability.

[0155] According to the comparison between Example 3 and Comparative Examples 1-3, it can be seen that the modified small molecule polyol prepared by using 2,2-dihydroxymethyl-1,3-propanediol, succinic anhydride and cashew phenol glycidyl ether can significantly improve the mechanical properties of the bandage and has a high air permeability.

[0156] According to the comparison between Example 3 and Comparative Examples 4-7, it can be seen that the modified small molecule polyol-coated nano zinc oxide prepared by using 2,2-dihydroxymethyl-1,3-propanediol, succinic anhydride and glycidyltrimethylammonium chloride not only improves the mechanical properties of the bandage, but also gives the bandage excellent antibacterial properties and improves the breathability to a certain extent.

[0157] The above description represents the preferred embodiments of the present invention. It should be noted that those skilled in the art can make various improvements and modifications without departing from the principles of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A self-adhesive antibacterial sponge bandage, characterized in that, The product includes antibacterial sponge, pressure-sensitive hot melt adhesive, and release paper. The raw materials for the antibacterial sponge, by weight, include: 100 parts of polyether polyol, 1-5 parts of modified small molecule polyol A, 3-6 parts of modified nano zinc oxide, 45-60 parts of isocyanate, 0.1-2 parts of silicone oil, 0.1-1 parts of catalyst, and 2-5 parts of foaming agent. The modified small molecule polyol A is prepared by reacting small molecule polyol A, acid anhydride A, and cashew phenol glycidyl ether.

2. The self-adhesive antibacterial sponge bandage according to claim 1, characterized in that, The self-adhesive antibacterial sponge bandage has an elongation at break of >150%, a tensile strength of >260KPa, and an air permeability of >330mL / cm². 2 / min, Escherichia coli inhibition rate >99%, Staphylococcus aureus >99%.

3. The self-adhesive antibacterial sponge bandage according to claim 2, characterized in that, The modified nano zinc oxide is prepared by coating nano zinc oxide with modified small molecule polyol B.

4. The self-adhesive antibacterial sponge bandage according to claim 3, characterized in that, The modified small molecule polyol B is prepared by reacting small molecule polyol B, acid anhydride B, and glycidyltrimethylammonium chloride.

5. The self-adhesive antibacterial sponge bandage according to claim 3 or 4, characterized in that, The small molecule polyol A is selected from at least one of 2,2-dihydroxymethyl-1,3-propanediol and bis(trimethylolpropane); the small molecule polyol B is selected from at least one of 2,2-dihydroxymethyl-1,3-propanediol and bis(trimethylolpropane).

6. The self-adhesive antibacterial sponge bandage according to claim 3 or 4, characterized in that, The acid anhydride A is selected from at least one of succinic anhydride, glutaric anhydride, maleic anhydride, and itaconic anhydride; the acid anhydride B is selected from at least one of succinic anhydride, glutaric anhydride, maleic anhydride, and itaconic anhydride.

7. The self-adhesive antibacterial sponge bandage according to claim 1, characterized in that, The modified small molecule polyol A is prepared by mixing small molecule polyol A, acid anhydride A and cashew phenol glycidyl ether, adding tetraethylammonium bromide, heating the mixture until the acid value is ≤2mgKOH / g, and then cooling it down to obtain the product.

8. The self-adhesive antibacterial sponge bandage according to claim 3, characterized in that, The modified nano zinc oxide is prepared by mixing nano zinc oxide, small molecule polyol B, acid anhydride B, glycidyltrimethylammonium chloride and acetone, adding tetraethylammonium bromide, heating and stirring until the acid value is ≤2mgKOH / g, cooling, filtering and rotary evaporation to obtain the product.

9. The self-adhesive antibacterial sponge bandage according to claim 7 or 8, characterized in that, The method for preparing the antibacterial sponge includes the following steps: mixing polyether polyol, modified small molecule polyol A, catalyst, silicone oil and foaming agent, adding modified nano zinc oxide and mixing, and finally adding isocyanate, foaming, curing and aging to obtain the final product.

10. The method for preparing the self-adhesive antibacterial sponge bandage according to any one of claims 1-9, characterized in that, Includes the following steps: Apply pressure-sensitive hot melt adhesive to the antibacterial sponge, cover it with release paper, apply pressure to bond, and then roll it up.

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