Membrane pump device and drug infusion system

Abstract

The application relates to a membrane pump device and a medicine injection and infusion system. The membrane pump device comprises a plurality of dosing chambers, a working flow channel, a power flow channel and a valve group. Each dosing chamber is provided with an elastic membrane, and the elastic membrane divides each dosing chamber into a first containing space and a second containing space. The working flow channel and the power flow channel each comprise an inlet section and an outlet section. The inlet section of the working flow channel and the outlet section of the working flow channel are in communication with the first containing space of each dosing chamber. The inlet section of the power flow channel and the outlet section of the power flow channel are in communication with the second containing space of each dosing chamber. The valve group comprises a plurality of valves, and the plurality of valves are respectively arranged in each inlet section and each outlet section. In the membrane pump device, when the membrane pump device is applied to the medicine injection and infusion system, one or more dosing chambers can be controlled to pump out medicine at the same time by arranging a plurality of dosing chambers, the injection and infusion precision and efficiency are high, and the high-precision injection and infusion requirement can be met.

Description

Technical Field

[0001] This application relates to the field of drug delivery technology, and in particular to membrane pump devices and drug delivery systems. Background Technology

[0002] In drug delivery, quantitative infusion is widely used in many scenarios. However, the single infusion dose of current infusion equipment is determined by the single pump volume. This approach has the following problems: quantitative infusion has poor accuracy and cannot meet the requirements of high-precision infusion; to meet the requirements of high-precision infusion, if the single pump volume of the infusion equipment is reduced, the infusion equipment needs to perform multiple infusions to achieve the single infusion dose, resulting in low infusion efficiency. Summary of the Invention

[0003] Therefore, it is necessary to address the above-mentioned problems by providing a membrane pump device and a drug delivery system.

[0004] In a first aspect, this application provides a membrane pump device, comprising: multiple metering tanks, a working flow channel, a power flow channel, and a valve assembly;

[0005] Each of the aforementioned metering cells is provided with an elastic membrane, which divides each of the aforementioned metering cells into a first accommodating space and a second accommodating space;

[0006] Both the working flow channel and the power flow channel include an inlet section and an outlet section; the inlet section and the outlet section of the working flow channel are connected to the first containment space of each of the metering cells; the inlet section and the outlet section of the power flow channel are connected to the second containment space of each of the metering cells.

[0007] The valve group includes multiple valves, which are located in each of the inlet sections and each of the outlet sections.

[0008] In the membrane pump device of this application, when the membrane pump device is applied to a drug delivery system, by setting multiple metering cells, one or more metering cells can be controlled to pump out drugs simultaneously, which has high delivery accuracy and delivery efficiency and can meet the requirements of high-precision delivery.

[0009] In one embodiment, the plurality of valves are first valves; the plurality of metering tanks include a first metering tank and a second metering tank;

[0010] The entry section of the working flow channel includes a first entry section and a second entry section; one end of the first entry section is connected to the first accommodating space of the first metering pool; one end of the second entry section is connected to the first accommodating space of the second metering pool.

[0011] The outflow section of the working flow channel includes a first outflow section and a second outflow section; one end of the first outflow section is connected to the first receiving space of the first metering tank; one end of the second outflow section is connected to the first receiving space of the second metering tank.

[0012] The inlet section of the power flow channel includes a third inlet section and a fourth inlet section. One end of the third inlet section is connected to the second containment space of the first metering pool; one end of the fourth inlet section is connected to the second containment space of the second metering pool.

[0013] The outflow section of the power flow channel includes a third outflow section and a fourth outflow section; one end of the third outflow section is connected to the second containment space of the first metering tank; one end of the fourth outflow section is connected to the second containment space of the second metering tank.

[0014] The first valve is provided on the first inlet section, the second inlet section, the third inlet section, the fourth inlet section, the first outlet section, the second outlet section, the third outlet section, and the fourth outlet section.

[0015] In one embodiment, the first valve on the first outflow section and the first valve on the third inflow section form a first group; the first valve on the first inflow section, the first valve on the third outflow section, the first valve on the second inflow section, and the first valve on the fourth outflow section form a second group; and the first valve on the second outflow section and the first valve on the fourth inflow section form a third group. Alternatively, the first valve on the first outflow section, the first valve on the third inflow section, the first valve on the second outflow section, and the first valve on the fourth inflow section form a first group; the first valve on the first inflow section and the first valve on the third outflow section form a second group; and the first valve on the second inflow section and the first valve on the fourth outflow section form a third group. Alternatively, the first valve on the first outflow section and the first valve on the third inflow section form a first group; the first valve on the second outflow section and the first valve on the fourth inflow section form a second group; the first valve on the first inflow section and the first valve on the third outflow section form a third group; and the first valve on the second inflow section and the first valve on the fourth outflow section form a fourth group. The opening and closing states of each first valve in each of the above groups are consistent.

[0016] In one embodiment, the plurality of valves include a plurality of first valves and a plurality of second valves; the plurality of metering tanks include a first metering tank and a second metering tank;

[0017] The entry section of the working flow channel includes a first main entry section, a first sub-entry section, and a second sub-entry section; one end of the first sub-entry section is connected to the first main entry section, and the other end is connected to the first accommodating space of the first metering pool; one end of the second sub-entry section is connected to the first main entry section, and the other end is connected to the second accommodating space of the second metering pool.

[0018] The outflow section of the working flow channel includes a first main outflow section, a first sub-outflow section, and a second sub-outflow section; one end of the first sub-outflow section is connected to the first main outflow section, and the other end is connected to the first containment space of the first metering pool; one end of the second sub-outflow section is connected to the first main outflow section, and the other end is connected to the first containment space of the second metering pool.

[0019] The entry section of the power flow channel includes a second main entry section, a third sub-entry section, and a fourth sub-entry section; one end of the third sub-entry section is connected to the second main entry section, and the other end is connected to the second containment space of the first metering pool; one end of the fourth sub-entry section is connected to the second main entry section, and the other end is connected to the second containment space of the second metering pool.

[0020] The outflow section of the power flow channel includes a second main outflow section, a third sub-outflow section, and a fourth sub-outflow section; one end of the third sub-outflow section is connected to the second main outflow section, and the other end is connected to the second containment space of the first metering tank; one end of the fourth sub-outflow section is connected to the second main outflow section, and the other end is connected to the second containment space of the second metering tank.

[0021] The first valve is provided on the first main inlet section, the first main outlet section, the second main inlet section, and the second main outlet section, and the second valve is provided on the first sub-inlet section, the second sub-inlet section, the third sub-inlet section, the fourth sub-inlet section, the first sub-outlet section, the second sub-outlet section, the third sub-outlet section, or the fourth sub-outlet section.

[0022] In one embodiment, the first valve on the first main inlet section and the first valve on the second main outlet section form a first group, the first valve on the first main outlet section and the first valve on the second main inlet section form a second group, and the second valve is a third group; the opening and closing states of each first valve and the second valve in each group are consistent.

[0023] In one embodiment, the inlet section of the working flow channel, the outlet section of the working flow channel, the inlet section of the power flow channel, and the outlet section of the power flow channel are all elastic bodies; the second valve includes: a sliding member, a spring, a shape memory alloy wire, and a pull rod;

[0024] The slider is located above the elastic body, and a groove-shaped guide rail is provided on one side of the slider, with a limiting structure inside the guide rail;

[0025] The spring is located above the slider and is in contact with the slider;

[0026] The shape memory alloy wire is connected to the slider and extends above the slider;

[0027] One end of the pull rod is located on one side of the slider, inside the guide rail, and can slide along the guide rail.

[0028] In one embodiment, the inlet section of the working flow channel, the outlet section of the working flow channel, the inlet section of the power flow channel, and the outlet section of the power flow channel are all elastomers; the membrane pump device includes: a slider, a first spring, a first shape memory alloy wire, a clamping element, a second spring, and a second shape memory alloy wire;

[0029] The slider is located above the elastic body, and a locking part is provided on one side of the slider;

[0030] The first spring is located above the slider and is connected to the slider;

[0031] The first shape memory alloy wire is connected to the slider and extends above the slider;

[0032] The card is located on one side of the slider, and when the card contacts the slider, it contacts the card slot portion;

[0033] The second spring is located at the end of the locking member away from the sliding member;

[0034] The second shape memory alloy wire is connected to the card and extends to the side of the card away from the slider.

[0035] Secondly, this application also provides a drug delivery system, the drug delivery system comprising:

[0036] The membrane pump device as described in the first aspect;

[0037] A medicine storage device, wherein the medicine storage device has a medicine storage chamber, and a piston is provided in the medicine storage chamber; the medicine outlet of the medicine storage device is connected to the inlet section of the working flow channel;

[0038] A power source, connected to the inlet section of the power flow channel, is used to inject driving fluid into the inlet section of the power flow channel.

[0039] In the drug delivery system of this application, since the membrane pump device is equipped with multiple metering pools, it is possible to control one or more metering pools to pump out drugs simultaneously, which has high delivery accuracy and delivery efficiency and can meet the requirements of high-precision delivery.

[0040] In one embodiment, the power source includes a proton exchange device or a fluid storage device.

[0041] In one embodiment, the end of the drug reservoir away from the drug outlet is provided with an inlet, which is connected to the power source; the power source also provides a driving fluid to the drug storage chamber through the inlet to drive the piston to move within the drug storage chamber. Attached Figure Description

[0042] Figure 1 This is a schematic diagram of the membrane pump device provided in one embodiment of this application;

[0043] Figure 2 This is a schematic diagram of the membrane pump device provided in another embodiment of this application;

[0044] Figure 3 This is a schematic cross-sectional view of the first valve provided in another embodiment of this application;

[0045] Figure 4 This is a schematic cross-sectional view of the first valve provided in another embodiment of this application;

[0046] Figure 5 This is a schematic cross-sectional view of the first valve provided in another embodiment of this application;

[0047] Figure 6 This is a schematic cross-sectional view of the second valve provided in another embodiment of this application;

[0048] Figure 7 for Figure 6 A three-dimensional structural diagram of the sliding element in the second valve;

[0049] Figure 8 This is a schematic cross-sectional view of the second valve provided in another embodiment of this application;

[0050] Figure 9 for Figure 8 The working principle diagram of the second valve described herein.

[0051] Figure 10 This is a schematic diagram of the structure of a drug infusion system provided in another embodiment of this application;

[0052] Figure 11 This is a schematic diagram of the structure of a drug infusion system provided in another embodiment of this application.

[0053] Component labeling: 101, First metering tank; 102, Second metering tank; 103, Working flow channel; 1030, First inlet section; 1031, Second inlet section; 1032, First outlet section; 1033, Second outlet section; 1034, First main inlet section; 1035, First sub-inlet section; 1036, Second sub-inlet section; 1037, First main outlet section; 1038, First sub-outlet section; 1039, Second sub-outlet section; 104, Power flow channel; 1040, Third inlet section; 1041. Fourth entry section; 1042. Third exit section; 1043. Fourth exit section; 1044. Second main entry section; 1045. Third sub-entry section; 1046. Fourth sub-entry section; 1047. Second main exit section; 1048. Third sub-exit section; 1049. Fourth sub-exit section; 1051, 1052, 1053, 1054, 1055, 1056, 1057, 1058. First valve; 1059. Second valve; 10511. Sliding component; 1051 2. Guide rail; 10513. Limiting structure; 10514. Spring; 10515. Memory alloy wire; 10516. Pull rod; 10521. Sliding component; 10522. First spring; 10523. First memory alloy wire; 10524. Clamping component; 10525. Second spring; 10526. Second memory alloy wire; 106. Elastomer; 20. Drug reservoir; 30. Power source; 40. Infusion pipeline; 301. Valve body; 302. Tensioning component; 303. Compression spring; 304. 3041. Valve seat; 3042. Contact part; 3043. Guide hole; 305, 315, 325. Extrusion structure; 306. Sliding shaft; 307, 317, 327. Elastic membrane; 318. Rotating shaft; 319, 320, 321. Actuating rod; 310. Liquid inlet; 311. Liquid passage; 312. Liquid outlet; 313. Connecting rod; 324. Compression spring; 325. Fixed shaft; 406. Power flow channel; 407. Working flow channel; 408. Metering tank; 409. Elastic membrane. Detailed Implementation

[0054] To facilitate understanding of this application, a more complete description will be provided below with reference to the accompanying drawings, which illustrate preferred embodiments of the application. However, this application may be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided so that the disclosure of this application will be thorough and complete.

[0055] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein in the specification of this application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0056] In the description of this application, it should be understood that the terms "upper", "lower", "vertical", "horizontal", "inner", "outer", etc., indicate the orientation or positional relationship based on the method or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this application.

[0057] In one embodiment, see Figure 1 This application provides a membrane pump device, which includes: multiple metering tanks, a working flow channel 103, a power flow channel 104, and a valve group; wherein, each metering tank is provided with an elastic membrane (not shown), which divides each metering tank into a first accommodating space (not shown) and a second accommodating space (not shown); the working flow channel 103 and the power flow channel 104 each include an inlet section and an outlet section; the inlet section and the outlet section of the working flow channel 103 are connected to the first accommodating space of each metering tank; the inlet section and the outlet section of the power flow channel 104 are connected to the second accommodating space of each metering tank; the valve group includes multiple valves, which are respectively located in each inlet section and each outlet section.

[0058] In the membrane pump device of this application, when the membrane pump device is applied to a drug delivery system, by setting multiple metering cells, one or more metering cells can be controlled to pump out drugs simultaneously, which has high delivery accuracy and delivery efficiency and can meet the requirements of high-precision delivery.

[0059] As an example, the membrane pump device of this embodiment can be formed by 3D printing, and the power flow channel 104 and the working flow channel 103 can be microchannels. The integration of the flow channels is achieved through 3D printing technology, which allows for a smaller volume of the flow channel structure with the elastic membrane. Furthermore, fluid microfluidics technology can be used to fabricate the membrane pump device into a thin, sheet-like structure. The power flow channel 104 and the working flow channel 103 can be elastomers (e.g., having an elastic membrane or a flexible tube) located within the microchannels.

[0060] As an example, when the elastic membrane in the metering tank is in a flat state, the volumes of the first and second accommodating spaces can be related to the flow rate of the fluid to be transported through three-dimensional modeling or dimensional design. Furthermore, the elasticity of the membrane is set to be related to the pressure of the pumped fluid. Specifically, the metering tank can be a groove-shaped structure connected to the working flow channel 103 and the power flow channel 104.

[0061] In one embodiment, please continue reading Figure 1 The multiple valves are all first valves; the multiple metering tanks may include a first metering tank 101 and a second metering tank 102; the inlet section of the working flow channel 103 includes a first inlet section 1030 and a second inlet section 1031; one end of the first inlet section 1030 is connected to the first accommodating space of the first metering tank 101; one end of the second inlet section 1031 is connected to the first accommodating space of the second metering tank 102; the outlet section of the working flow channel 103 includes a first outlet section 1032 and a second outlet section 1033; the first outlet section 1032... One end of the outlet section 1032 is connected to the first containment space of the first metering tank 101; one end of the second outlet section 1033 is connected to the first containment space of the second metering tank 102; the inlet section of the power flow channel 104 includes a third inlet section 1040 and a fourth inlet section 1041, one end of the third inlet section 1040 is connected to the second containment space of the first metering tank 101; one end of the fourth inlet section 1041 is connected to the second containment space of the second metering tank 102; the outlet section of the power flow channel 104 includes The third outflow section 1042 and the fourth outflow section 1043; one end of the third outflow section 1042 is connected to the second containment space of the first metering tank 101; one end of the fourth outflow section 1043 is connected to the second containment space of the second metering tank 102; the first inflow section 1030, the second inflow section 1031, the third inflow section 1040, the fourth inflow section 1041, the first outflow section 1032, the second outflow section 1033, the third outflow section 1042 and the fourth outflow section 1043 are connected to the second containment space of the second metering tank 102; Each section is equipped with the first valve; specifically, the first valve 1053 is located on the first inlet section 1030, the first valve 1057 is located on the second inlet section 1031, the first valve 1054 is located on the first outlet section 1032, the first valve 1058 is located on the second outlet section 1033, the first valve 1051 is located on the third inlet section 1040, the first valve 1055 is located on the fourth inlet section 1041, the first valve 1052 is located on the third outlet section 1042, and the first valve 1056 is located on the fourth outlet section 1043.

[0062] In one example, the first valve 1054 on the first outflow section 1032 and the first valve 1051 on the third inflow section 1040 form a first group; the first valve 1053 on the first inflow section 1030, the first valve 1052 on the third outflow section 1042, the first valve 1057 on the second inflow section 1031 and the first valve 1056 on the fourth outflow section 1043 form a second group; and the first valve 1058 on the second outflow section 1033 and the first valve 1055 on the fourth inflow section 1041 form a third group. The opening and closing states of each first valve in each group are consistent, that is, each first valve in each group can be linked and controlled to open and close simultaneously.

[0063] In another example, the first valve 1054 on the first outflow section 1032, the first valve 1051 on the third inflow section 1040, the first valve 1058 on the second outflow section 1033, and the first valve 1055 on the fourth inflow section 1041 form a first group; the first valve 1053 on the first inflow section 1030 and the first valve 1052 on the third outflow section 1042 form a second group; and the first valve 1057 on the second inflow section 1031 and the first valve 1056 on the fourth outflow section 1043 form a third group. The opening and closing states of each first valve in each group are consistent, that is, each first valve in each group can be linked and controlled to open and close simultaneously.

[0064] In another example, the first valve 1054 on the first outflow section 1032 and the first valve 1051 on the third inflow section 1040 form a first group; the first valve 1058 on the second outflow section 1033 and the first valve 1055 on the fourth inflow section 1041 form a second group; the first valve 1053 on the first inflow section 1030 and the first valve 1052 on the third outflow section 1042 form a third group; and the first valve 1057 on the second inflow section 1031 and the first valve 1056 on the fourth outflow section 1043 form a fourth group. The opening and closing states of each first valve in each group are consistent, that is, each first valve in each group can be linked and controlled to open and close simultaneously.

[0065] In another embodiment, please refer to Figure 2The plurality of valves may include a plurality of first valves and second valves; the plurality of metering tanks include a first metering tank 101 and a second metering tank 102; the entry section of the working flow channel 103 includes a first main entry section 1034, a first sub-entry section 1035, and a second sub-entry section 1036; one end of the first sub-entry section 1035 is connected to the first main entry section 1034, and the other end is connected to the first accommodating space of the first metering tank 101; one end of the second sub-entry section 1036 is connected to the first main entry section 1034, and the other end is connected to the second accommodating space of the second metering tank 102; the working flow channel 103... The outflow section of the 3 includes a first main outflow section 1037, a first sub-outflow section 1038, and a second sub-outflow section 1039; one end of the first sub-outflow section 1038 is connected to the first main outflow section 1037, and the other end is connected to the first containment space of the first metering pool 101; one end of the second sub-outflow section 1039 is connected to the first main outflow section 1037, and the other end is connected to the first containment space of the second metering pool 102; the inflow section of the power flow channel 104 includes a second main inflow section 1044, a third sub-inflow section 1045, and a fourth sub-inflow section 1046; one end of the third sub-inflow section 1045... The first main inlet section 1046 is connected to the second main inlet section 1044 at one end and to the second containment space of the first metering pool 101 at the other end; the fourth sub-inlet section 1046 is connected to the second main inlet section 1044 at one end and to the second containment space of the second metering pool 102 at the other end; the outlet section of the power flow channel 104 includes a second main outlet section 1047, a third sub-outlet section 1048, and a fourth sub-outlet section 1049; one end of the third sub-outlet section 1048 is connected to the second main outlet section 1047 at one end and to the second containment space of the first metering pool 101 at the other end; the fourth sub-outlet section 1049... One end is connected to the second main outlet section 1047, and the other end is connected to the second containment space of the second metering pool 102; the first valve is provided on the first main inlet section 1034, the first main outlet section 1037, the second main inlet section 1044, and the second main outlet section 1047; the second valve is provided on the first sub-inlet section 1035, the second sub-inlet section 1036, the third sub-inlet section 1045, the fourth sub-inlet section 1046, the first sub-outlet section 1038, the second sub-outlet section 1039, the third sub-outlet section 1048, or the fourth sub-outlet section 1049.Specifically, the second valve can be one, located on any one of the following sub-entry or sub-outflow sections: the first sub-inflow section 1035, the second sub-inflow section 1036, the third sub-inflow section 1045, the fourth sub-inflow section 1046, the first sub-outflow section 1038, the second sub-outflow section 1039, the third sub-outflow section 1048, or the fourth sub-outflow section 1049. Alternatively, there can be multiple second valves, each located on one or more of the following sub-entry or sub-outflow sections: the first sub-inflow section 1035, the second sub-inflow section 1036, the third sub-inflow section 1045, the fourth sub-inflow section 1046, the first sub-outflow section 1038, the second sub-outflow section 1039, the third sub-outflow section 1048, or the fourth sub-outflow section 1049.

[0066] As an example, the valve on the first main inlet section 1034 is the first valve 1053, the valve on the first main outlet section 1037 is the first valve 1054, the valve on the second main inlet section 1044 is the first valve 1051, the valve on the second main outlet section 1047 is the first valve 1052, and the valves on the first sub-inlet section 1035, the second sub-inlet section 1036, the third sub-inlet section 1045, the fourth sub-inlet section 1046, the first sub-outlet section 1038, the second sub-outlet section 1039, the third sub-outlet section 1048, or the fourth sub-outlet section 1049 are the second valves 1059.

[0067] As an example, the first valve 1053 on the first main inlet section 1034 and the first valve 1052 on the second main outlet section 1047 form a first group; the first valve 1054 on the first main outlet section 1037 and the first valve 1051 on the second main inlet section 1044 form a second group; and the second valve 1059 on the first sub-inlet section 1035, the second sub-inlet section 1036, the third sub-inlet section 1045, the fourth sub-inlet section 1046, the first sub-outlet section 1038, the second sub-outlet section 1039, the third sub-outlet section 1048, or the fourth sub-outlet section 1049 forms a third group; the opening and closing states of each first valve and second valve in each group are consistent.

[0068] As an example, the capacity of the first metering cell 101 may be the same as or different from the capacity of the second metering cell 102.

[0069] As an example, please continue reading Figure 1 and Figure 2The first valve of this application may each include an elastic body as a part of the flow channel and a squeezing structure placed on the non-flow channel side of the elastic body for driving the movement of the elastic body. Under the drive of the squeezing structure, the elastic body moves towards the flow channel side to block the flow channel. The valve assembly of this application may also include a linkage mechanism to realize the linkage of the first valve. The linkage mechanism includes: an actuating member connected to the squeezing structure, and a power member controlling the movement of the actuating member; when the power member is activated, one of the multiple squeezing structures presses against the elastic body to block the flow channel, and another of the multiple squeezing structures moves away from the elastic membrane to make the flow channel open; or, when the power member is activated, all of the multiple squeezing structures press against the elastic body to block the flow channel.

[0070] In one embodiment, see Figure 3 ,like Figure 3 As shown, in this embodiment, the actuating component is a valve seat 304 with multiple abutment portions 3041, each abutment portion 3041 contacting a compression structure 305; the power component includes a compression component and an electrically controlled retractable tension component 302. The compression component is placed between the valve body 301 and the valve seat 304 and provides elastic force to the valve seat 304. The tension component 302 is fixedly disposed between the valve seat 304 and the valve body 301. In this embodiment, the compression component can be a compression spring 303, and the elastic body can be an elastic membrane 307 or formed of a hose material. When the tension component 302 is de-energized, the valve seat 304 moves towards the elastic membrane 307 under the elastic force of the compression spring 303, thereby squeezing or blocking the flow channel. When the tension component 302 is energized, the valve seat 304 moves away from the elastic membrane 307 under the pull of the tension component 302, overcoming the elastic force of the compression spring 303. In this embodiment, the electrically controlled retractable tension member 302 is used as the power source, which drives the valve seat to move relative to the valve body, thereby causing the extrusion structure to move. This enables the elastic membrane to move into the flow channel, thereby extruding or blocking the flow channel. The linkage mechanism in this embodiment enables multiple extrusion structures to move in the same direction at the same time, that is, it controls multiple flow channels to be disconnected and flow at the same time.

[0071] The aforementioned tensioning component can be a shape memory alloy wire. For better installation and energization, both ends of the shape memory alloy wire are connected to an electrode and fixed to the valve body 301. In this embodiment, the electrode can be a metal sheet. The middle of the shape memory alloy wire is wound around the sliding shaft 306 on the valve seat 304. When the two electrodes are energized by an external power source, i.e., the shape memory alloy wire is energized and shortens, a contraction force is generated, which pulls the valve seat 304 upward through the sliding shaft 306. The compression structure 305 no longer exerts a resistance force, and thus the compression structure 305 removes its resistance force on the elastic membrane 307. The elastic membrane returns to flatness, and at this time, the flow channels corresponding to the elastic membrane are connected.

[0072] As an example, the actuator can be a valve seat 304 with two abutments 3041.

[0073] To further ensure the linear movement of the extrusion structure 305, a guide hole 3042 for accommodating the extrusion structure 305 is provided on the valve body 301.

[0074] The extrusion structure 305 described above is a sphere, which can be a hard sphere or a spherical crown. It can be directly fixed to the contact part of the valve seat (such as being directly embedded in the contact part), or it can be contacted as in 3, which is not limited here.

[0075] In another embodiment, please refer to Figure 4 ,like Figure 4 As shown, in this embodiment, the aforementioned actuator is a rotating trigger rod 312. The trigger rod 312 is in contact with multiple extrusion structures 315, and the multiple extrusion structures 315 move relative to the elastic body under the action of the trigger rod 312 in opposite directions. One of the multiple extrusion structures 315 presses against the elastic body (in this embodiment, the elastic body is an elastic membrane 317, which can also be formed of a flexible tube material) to extrude or block the flow channel, while another of the multiple extrusion structures 315 moves away from the elastic membrane 317 to connect the flow channels. In this embodiment, the movement of the trigger rod 312 achieves the linkage control of multiple extrusion structures 315, and controls the multiple extrusion structures 315 to move in opposite directions. In this embodiment, the extrusion structure 315 is a sphere or a spherical crown-shaped structure, but it is not limited to these; it can be a block-shaped structure or the like.

[0076] As a specific structure, the aforementioned trigger rod 312 is a lever-type installation, that is, the rotation center of the trigger rod 312 is located between two adjacent extrusion structures 315. The trigger rod 312 is rotatably mounted on the rotation shaft 311. Under the drive of the drive unit (not shown), the trigger rod reciprocates, that is, it moves clockwise or counterclockwise, so that pressure is applied to only one of the multiple extrusion structures, causing the extrusion structure to press against the elastic membrane 317 and thus squeeze or block the flow channel.

[0077] To better resist the extrusion structure 315, the extrusion structure 315 is a sphere, and the actuating rod 312 is provided with a plurality of protrusions that respectively resist the extrusion structure, and the rotation center of the actuating rod is located between two adjacent protrusions.

[0078] In this embodiment, the microvalve assembly has a flow channel in its valve body. The flow channel is divided into two sections, and each section has the aforementioned elastic membrane. That is, multiple extrusion structures are used to alternately block the flow channel in the same flow channel, which can realize forward-pushing actuation of the fluid. Figure 4As shown, the flow channel includes a liquid inlet 313, a liquid channel 314, and a liquid outlet 316. The elastic membrane 317 can be a single, integral membrane located on one side of the flow channel, or two membranes located at desired positions. The liquid inlet 313, liquid channel 314, and liquid outlet 316 are interconnected. The elastic membrane 317 seals the liquid channel 314. Multiple extrusion structures 315 contact the elastic membrane 317. A protrusion on an actuating rod 312 presses against one of the extrusion structures. The actuating rod 312 can rotate around a rotation axis 311. Under the pressure of the protrusion on the actuating rod 312, the elastic membrane of the extrusion structure 315 deforms, sealing the liquid channel 314. During the counterclockwise rotation of the actuating rod 312, the extrusion structure on the right side of the diagram loses pressure on the elastic membrane 317, while the extrusion structure on the left side deforms the elastic membrane 317. At this time, the liquid in the liquid channel of the left extrusion structure is pressurized and moves towards the liquid outlet 316. As the trigger rod 312 rotates clockwise, the pressure of the right-side extrusion structure on the elastic membrane 317 increases, while the pressure of the left-side extrusion structure on the elastic membrane 317 decreases. The liquid in the liquid channel under the right-side extrusion structure is then pressurized and transferred to the liquid channel under the left-side extrusion structure. During the repeated clockwise and counterclockwise rotation of the trigger rod 312, the liquid enters from the liquid inlet 313 and is controlled to exit from the liquid outlet 316.

[0079] In yet another embodiment, please refer to Figure 5 There are two actuating rods 323, each in contact with a compression structure 325. The two actuating rods 323 are connected by a connecting rod 321. Under the action of the connecting rod 321, one of the actuating rods presses the compression structure 325 in contact with it against the elastic membrane 327, while the other actuating rod moves the compression structure in contact with it away from the elastic membrane 327.

[0080] The actuating rod 323 can rotate along the fixed shaft 324. Both actuating rods 323 rotate synchronously clockwise or counterclockwise. In this embodiment, one actuating rod 323 is connected to a compression spring 322. The compression spring 322 is in a compressed state and contacts one of the actuating rods 323, providing clockwise rotational pressure to the actuating rod 323. When no external force is involved, the two actuating rods 323 rotate clockwise. The protrusion of one actuating rod 323 contacts the extrusion structure 325, extruding the elastic membrane 327 to close the liquid passage; the protrusion of the other actuating rod 323 disengages from the hard ball, opening the liquid passage.

[0081] Similarly, by symmetrically arranging two sets of the above-mentioned microvalve assemblies, with the elastic membranes in the same set located in different flow channels, four valves can be formed to control the two flow channels, which can be applied to membrane pump devices.

[0082] It should be noted that, Figure 5 In the middle, 401 is the power flow channel (i.e. Figure 1 , Figure 2 , Figure 7 and Figure 8 The power flow channel 104), and the working flow channel 402 (i.e. Figure 1 , Figure 2 , Figure 7 and Figure 8 The working channel 103 in the middle), 403 is the metering tank (which can be a working channel 103 ... Figure 1 , Figure 2 , Figure 7 and Figure 8 The first quantitative cell 101 or the second quantitative cell 102), and 404 is the elastic membrane at the quantitative cell 403.

[0083] For example, please refer to Figure 6 and Figure 7 The inlet section, outlet section, inlet section, and outlet section of the power flow channel 104 are all elastic bodies 106; the second valve may include: a sliding member 10511, a spring 10514, a shape memory alloy wire 10515, and a pull rod 10516; the sliding member 10511 is located above the elastic body 106, and a grooved guide rail 10512 is provided on one side of the sliding member 10511. The guide rail 10512 is provided with a limiting structure 10513; the spring 10514 is located above the slider 10511 and is in contact with the slider 10511; the shape memory alloy wire 10515 is connected to the slider 10511 and extends above the slider 10511; one end of the pull rod 10516 is located on one side of the slider 10511, inside the guide rail 10512, and can slide along the guide rail 10512.

[0084] In the second valve of this embodiment, the limiting structure 10513 on the guide rail 10512 cooperates with the pull rod 10516 to form a self-locking mechanism, fixing the sliding member 10511 at a certain height. The spring 10514 provides a downward force to the sliding member 10511, squeezing the elastic body 106 so that the elastic body 106 is not fully closed, thereby achieving the closure of the elastic body 106 through the second valve. The shape memory alloy wire 10515 provides an upward pulling force to the sliding member 10511. Each operation of the shape memory alloy wire 10515 results in a change in the state of the second valve. The working process of the second valve is as follows:

[0085] S1: In the initial state, there is no shape memory wire force. The spring 10514 applies a downward force, and the pull rod 10516 presses against the P1 position and locks itself. At this time, the elastic body 106 is compressed and the air passage is closed.

[0086] S2: When the shape memory alloy wire 10515 is working, the sliding member 10511 is pulled up, and the pull rod 10516 slides to P2. After the force of the shape memory alloy wire is removed, the pull rod 10516 can only slide towards P3 because the step is stuck. It is stuck at P3. At this time, the sliding member 10511 has been pulled up by 0.6-0.7mm. The elastic body 106 is not completely closed, and the air passage is opened.

[0087] S3: The shape memory alloy wire 10515 is activated again, the sliding member 10511 is pulled up, and the pull rod 10516 slides to P4. After the force of the shape memory alloy wire is removed, the pull rod 10516 can only slide towards P1 because the step is stuck, and finally returns to P1. At this time, the second valve returns to the state in S1 above, the elastic body 106 is compressed, and the air circuit is closed.

[0088] In another embodiment, please refer to Figure 8 and Figure 9 The inlet section, outlet section, inlet section, and outlet section of the power flow channel 104 are all elastomers 106. The membrane pump device includes: a slider 10521, a first spring 10522, a first shape memory alloy wire 10523, a locking member 10524, a second spring 10525, and a second shape memory alloy wire 10526. The slider 10521 is located above the elastomer 106, and a locking part (not shown) is provided on one side of the slider 10521. The first spring 10522 is located above the slider 10521 and is connected to the elastomer 106. The first shape memory alloy wire 10523 is connected to the slider 10521 and extends above the slider 10521; the locking member 10524 is located on one side of the slider 10521, and when the locking member 10524 contacts the slider 10521, it contacts the locking part; the second spring 10525 is located at the end of the locking member 10524 away from the slider 10521; the second shape memory alloy wire 10526 is connected to the locking member 10524 and extends to the side of the locking member 10524 away from the slider 10521.

[0089] As an example, the locking part can be a slot or an outwardly protruding locking block structure.

[0090] In the second valve of this embodiment, in the initial state, under the action of the second spring force 10525, the protruding part of the locking member 10524 cancels out the force of the first spring 10522 on the sliding member 10521, and the sliding member 10521 does not compress the elastic body 106, so the second valve opens. Figure 9As shown in Figure (a). When the second shape memory alloy wire 10526 is working, the locking piece 10524 is pulled to the right, and the protruding part of the locking piece 10524 no longer contacts the sliding piece 10511. Under the action of the first spring 10522, the sliding piece 10511 moves downward to compress the elastic body 106, and the second valve closes. Figure 9 As shown in Figure (b), when the first shape memory alloy wire 10523 is working, the slider 10521 is pulled upward, and the locking member 10524 is re-locked into the slider 10511 under the action of the second spring force 10525, returning to the initial state.

[0091] In one embodiment, see Figure 10 This application also provides a drug delivery system, which may include:

[0092] like Figures 1 to 9 The membrane pump device described in the corresponding embodiment;

[0093] The medicine storage device 20 has a medicine storage chamber (not shown) and a piston (not shown) is provided in the medicine storage chamber; the medicine outlet of the medicine storage device 20 is connected to the inlet section of the working flow channel 103.

[0094] A power source 30 is connected to the inlet section of the power flow channel 104 and is used to inject driving fluid into the inlet section of the power flow channel 104.

[0095] In the drug delivery system of this application, since the membrane pump device is equipped with multiple metering pools, it is possible to control one or more metering pools to pump out drugs simultaneously, which has high delivery accuracy and delivery efficiency and can meet the requirements of high-precision delivery.

[0096] As an example, the power source 30 may include a proton exchange device or a fluid storage device; the driving fluid may include, but is not limited to, gas.

[0097] As an example, the end of the drug reservoir 20 away from the drug outlet is provided with an inlet (not shown), which is connected to the power source 30; the power source 30 also provides a driving fluid to the drug storage chamber through the inlet to drive the piston to move within the drug storage chamber.

[0098] In one embodiment, see Figure 1 and Figure 10 The membrane pump device in the drug infusion system can be as follows: Figure 1The membrane pump structure corresponding to the embodiment; the working principle of the drug infusion system in this embodiment is as follows: when the first valve 1053 on the first inlet section 1030, the first valve 1052 on the third outlet section 1042, the first valve 1057 on the second inlet section 1031, and the first valve 1056 on the fourth outlet section 1043 are open, and the remaining first valves are closed, the drug solution in the drug reservoir 20 enters the first metering tank 101 and the second metering tank 102; when the first valve 1054 on the first outlet section 1032 and the first valve 1051 on the third inlet section 1040 are open, and the remaining first valves are closed. When the first valve 1058 on the second outflow section 1033 and the first valve 1055 on the fourth inflow section 1041 are open, and the other first valves are closed, the medicine in the second metering tank 102 is discharged; when the first valve 1054 on the first outflow section 1032, the first valve 1051 on the third inflow section 1040, the first valve 1058 on the second outflow section 1033 and the first valve 1055 on the fourth inflow section 1041 are open, and the other first valves are closed, the medicine in the first metering tank 101 and the second metering tank 102 are discharged simultaneously.

[0099] Assuming the single-step dose of the first metering cell 101 is 0.1U and the single-step dose of the second metering cell 102 is 0.05U, if the total required infusion dose is 0.25U, then the first metering cell 101 will output twice, and the second metering cell 102 will output once. Compared to a metering cell with only 0.1U, this improves infusion accuracy; compared to a metering cell with only 0.05U, it reduces the number of infusions, decreases the number of times the first valve opens and closes, and saves energy.

[0100] In another embodiment, please refer to Figure 2 and Figure 11 The membrane pump device of the drug infusion system in this embodiment can be as follows: Figure 2The membrane pump device corresponding to this embodiment works as follows: When the second valve 1059 is closed, the first valves 1052 and 1053 are open, and the first valves 1051 and 1054 are closed. The drug solution in the reservoir 20 enters the first metering pool 101 and the second metering pool 102. When the first valves 1051 and 1054 are open, and the first valves 1052 and 1053 are closed, only the drug solution in the first metering pool 101 is output. When the second valve 1059 is open, the first valves 1052 and 1053 are open, and the first valves 1051 and 1054 are closed. The drug solution in the reservoir 20 enters the first metering pool 101 and the second metering pool 102. When the first valves 1051 and 1054 are open, and the first valves 1052 and 1053 are closed, both the drug solutions in the first metering pool 101 and the second metering pool 102 are output.

[0101] Assuming the single-step dose of the first metering pool 101 is 0.05U and the single-step dose of the second metering pool 102 is 0.05U, if the total required infusion dose is 0.25U, then with the second valve 1059 open, both the first metering pool 101 and the second metering pool 102 will output twice; with the second valve 1059 closed, the first metering pool 101 will output once. Compared to a metering pool with only 0.1U, this improves infusion accuracy; compared to a metering pool with only 0.05U, it reduces the number of infusions, decreases the number of opening and closing cycles of the first and second valves, and saves energy.

[0102] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0103] The embodiments described above are merely illustrative of several implementation methods of this application, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the invention patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this application, and these all fall within the protection scope of this application. Therefore, the protection scope of this patent application should be determined by the appended claims.

Claims

1. A membrane pump device, characterized in that, include: Multiple metering tanks, working flow channels, power flow channels, and valve assemblies; Each of the aforementioned metering cells is provided with an elastic membrane, which divides each of the aforementioned metering cells into a first accommodating space and a second accommodating space; Both the working flow channel and the power flow channel include an inlet section and an outlet section; the inlet section and the outlet section of the working flow channel are connected to the first containment space of each of the metering cells; the inlet section and the outlet section of the power flow channel are connected to the second containment space of each of the metering cells. The valve group includes multiple valves, which are located in each of the inlet sections and each of the outlet sections.

2. The membrane pump device according to claim 1, characterized in that, The plurality of valves are first valves; the plurality of metering cells include a first metering cell and a second metering cell; The entry section of the working flow channel includes a first entry section and a second entry section; one end of the first entry section is connected to the first accommodating space of the first metering pool; one end of the second entry section is connected to the first accommodating space of the second metering pool. The outflow section of the working flow channel includes a first outflow section and a second outflow section; one end of the first outflow section is connected to the first receiving space of the first metering tank; one end of the second outflow section is connected to the first receiving space of the second metering tank. The inlet section of the power flow channel includes a third inlet section and a fourth inlet section. One end of the third inlet section is connected to the second containment space of the first metering pool; one end of the fourth inlet section is connected to the second containment space of the second metering pool. The outflow section of the power flow channel includes a third outflow section and a fourth outflow section; one end of the third outflow section is connected to the second containment space of the first metering tank; one end of the fourth outflow section is connected to the second containment space of the second metering tank. The first valve is provided on the first inlet section, the second inlet section, the third inlet section, the fourth inlet section, the first outlet section, the second outlet section, the third outlet section, and the fourth outlet section.

3. The membrane pump device according to claim 2, characterized in that, The first valve on the first outflow section and the first valve on the third inflow section form a first group; the first valve on the first inflow section, the first valve on the third outflow section, the first valve on the second inflow section, and the first valve on the fourth outflow section form a second group; the first valve on the second outflow section and the first valve on the fourth inflow section form a third group; or the first valve on the first outflow section, the first valve on the third inflow section, the first valve on the second outflow section, and the first valve on the fourth inflow section form a first group; the first valve on the first inflow section and the first valve on the third outflow section form a second group; the first valve on the second inflow section and the first valve on the fourth outflow section form a third group; or the first valve on the first outflow section and the first valve on the third inflow section form a first group; the first valve on the second outflow section and the first valve on the fourth inflow section form a second group; the first valve on the first inflow section and the first valve on the third outflow section form a third group; the first valve on the second inflow section and the first valve on the fourth outflow section form a fourth group; the opening and closing states of each first valve in each group are consistent.

4. The membrane pump device according to claim 1, characterized in that, The plurality of valves includes a plurality of first valves and a plurality of second valves; the plurality of metering tanks includes a first metering tank and a second metering tank; The entry section of the working flow channel includes a first main entry section, a first sub-entry section, and a second sub-entry section; one end of the first sub-entry section is connected to the first main entry section, and the other end is connected to the first accommodating space of the first metering pool; one end of the second sub-entry section is connected to the first main entry section, and the other end is connected to the second accommodating space of the second metering pool. The outflow section of the working flow channel includes a first main outflow section, a first sub-outflow section, and a second sub-outflow section; one end of the first sub-outflow section is connected to the first main outflow section, and the other end is connected to the first containment space of the first metering pool; one end of the second sub-outflow section is connected to the first main outflow section, and the other end is connected to the first containment space of the second metering pool. The entry section of the power flow channel includes a second main entry section, a third sub-entry section, and a fourth sub-entry section; one end of the third sub-entry section is connected to the second main entry section, and the other end is connected to the second containment space of the first metering pool; one end of the fourth sub-entry section is connected to the second main entry section, and the other end is connected to the second containment space of the second metering pool. The outflow section of the power flow channel includes a second main outflow section, a third sub-outflow section, and a fourth sub-outflow section; one end of the third sub-outflow section is connected to the second main outflow section, and the other end is connected to the second containment space of the first metering tank; one end of the fourth sub-outflow section is connected to the second main outflow section, and the other end is connected to the second containment space of the second metering tank. The first valve is provided on the first main inlet section, the first main outlet section, the second main inlet section, and the second main outlet section, and the second valve is provided on the first sub-inlet section, the second sub-inlet section, the third sub-inlet section, the fourth sub-inlet section, the first sub-outlet section, the second sub-outlet section, the third sub-outlet section, or the fourth sub-outlet section.

5. The membrane pump device according to claim 4, characterized in that, The first valve on the first main inlet section and the first valve on the second main outlet section form a first group, the first valve on the first main outlet section and the first valve on the second main inlet section form a second group, and the second valve is a third group; the opening and closing states of each first valve and second valve in each group are consistent.

6. The membrane pump device according to claim 4, characterized in that, The inlet section of the working flow channel, the outlet section of the working flow channel, the inlet section of the power flow channel, and the outlet section of the power flow channel are all elastic bodies; the second valve includes: a sliding element, a spring, a shape memory alloy wire, and a pull rod; The slider is located above the elastic body, and a groove-shaped guide rail is provided on one side of the slider, with a limiting structure inside the guide rail; The spring is located above the slider and is in contact with the slider; The shape memory alloy wire is connected to the slider and extends above the slider; One end of the pull rod is located on one side of the slider, inside the guide rail, and can slide along the guide rail.

7. The membrane pump device according to claim 4, characterized in that, The inlet section of the working flow channel, the outlet section of the working flow channel, the inlet section of the power flow channel, and the outlet section of the power flow channel are all elastic bodies; the second valve includes: a sliding member, a first spring, a first shape memory alloy wire, a locking member, a second spring, and a second shape memory alloy wire; The slider is located above the elastic body, and a locking part is provided on one side of the slider; The first spring is located above the slider and is connected to the slider; The first shape memory alloy wire is connected to the slider and extends above the slider; The card is located on one side of the slider, and when the card contacts the slider, it contacts the card slot portion; The second spring is located at the end of the locking member away from the sliding member; The second shape memory alloy wire is connected to the card and extends to the side of the card away from the slider.

8. A drug delivery system, characterized in that, include: The membrane pump device as described in any one of claims 1 to 7; A medicine storage device, wherein the medicine storage device has a medicine storage chamber, and a piston is provided in the medicine storage chamber; the medicine outlet of the medicine storage device is connected to the inlet section of the working flow channel; A power source, connected to the inlet section of the power flow channel, is used to inject driving fluid into the inlet section of the power flow channel.

9. The drug delivery system according to claim 8, characterized in that: The power source includes a proton exchange device or a fluid storage device.

10. The drug delivery system according to claim 8, characterized in that: The drug reservoir has an inlet at one end away from the drug outlet, and the inlet is connected to the power source; the power source also provides a driving fluid to the drug storage chamber through the inlet to drive the piston to move within the drug storage chamber.

Images