Olfactory rehabilitation training device

Abstract

The application discloses an olfactory rehabilitation training device, and relates to the technical field of animal experiment devices.The olfactory rehabilitation training device comprises a movable frame, a top cover assembly and an atomizing piece.The movable frame is surrounded by a movable cavity, and a first opening is arranged at the top of the movable frame and communicates with the movable cavity.The top cover assembly is arranged on the first opening, and the top cover assembly is provided with a liquid storage cavity and an atomizing cavity side by side.The atomizing cavity communicates with the liquid storage cavity and the movable cavity respectively, and the liquid storage cavity can input liquid to be atomized into the atomizing cavity.The atomizing piece is arranged in the atomizing cavity and is used for atomizing the liquid to be atomized.The application aims to save external pipelines, avoid atomizing piece immersion, reduce the volume and ensure operation reliability.

Description

Technical Field

[0001] This invention relates to the field of animal experimental equipment technology, and in particular to an olfactory rehabilitation training device. Background Technology

[0002] Olfactory dysfunction is a common complication of various diseases such as rhinitis, Alzheimer's disease, and Parkinson's disease. In order to study the plasticity mechanism of the olfactory center in depth and develop effective rehabilitation strategies accordingly, researchers usually choose mice as experimental animals. By repeatedly exposing mice to target odors in a specific environment, they simulate clinical olfactory rehabilitation training and evaluate the intervention effect.

[0003] In related technologies, there are mainly two types of training devices. One type involves setting up an independent atomizing mechanism outside the mouse's activity chamber, which is connected to the inside of the chamber via a connecting pipe to deliver atomized gas into the mouse's activity chamber. The other type integrates an atomizing plate directly into the bottom of the activity chamber, allowing the atomizing plate to be continuously immersed in liquid, and using the high-frequency vibration of the atomizing plate to atomize the liquid.

[0004] However, both of the above solutions have certain technical drawbacks in practical applications. For the external nebulizer solution, during the process of delivering the atomized gas to the active chamber via tubing, because the tubing temperature is usually lower than the atomization temperature, some aerosol will condense and adhere to the tubing wall surface, resulting in a lower actual gas concentration reaching the chamber and causing deviations in test data. For the bottom-integrated atomizing plate solution, since the atomizing plate needs to be immersed in liquid for a long time, the corrosive components in the liquid will continuously erode the atomizing plate, not only affecting its lifespan but also causing a gradual decrease in atomization efficiency, thus affecting the reliability of rehabilitation training. Summary of the Invention

[0005] The main objective of this invention is to propose an olfactory rehabilitation training device that eliminates the need for external piping and avoids soaking the atomizing sheet, thereby reducing its size and ensuring operational reliability.

[0006] To achieve the above objectives, the present invention proposes an olfactory rehabilitation training device, the olfactory rehabilitation training device comprising: A movable frame, wherein the movable frame is configured to form a movable cavity, and the top of the movable frame is provided with a first opening communicating with the movable cavity; A top cover assembly, wherein the top cover assembly covers the first opening, and the top cover assembly has a liquid storage chamber and an atomizing chamber arranged side by side, the atomizing chamber communicating with the liquid storage chamber and the movable chamber respectively, and the liquid storage chamber being able to input the liquid to be atomized into the atomizing chamber; and An atomizing element is disposed within the atomizing chamber and is used to atomize the liquid to be atomized.

[0007] In one embodiment, the top cover assembly includes: A substrate, wherein the substrate is enclosed to form an accommodating groove, the bottom wall of the substrate covers the first opening, and the bottom wall of the substrate is provided with a first communicating port; A cover body, the cover body being disposed over the opening of the receiving groove; A first seat, disposed within the receiving groove and surrounding the liquid storage cavity, wherein the side wall of the first seat is provided with a second communication port communicating with the liquid storage cavity; and The second seat is disposed in the receiving groove and connected to the first seat. The second seat surrounds and forms the atomizing cavity. The atomizing cavity is connected to the liquid storage cavity through the second connecting port and to the movable cavity through the first connecting port.

[0008] In one embodiment, the top of the second base is provided with a second opening communicating with the atomizing chamber, and the atomizing element is detachably inserted into the atomizing chamber through the second opening.

[0009] In one embodiment, the atomizing element includes: A cover plate, the shape of which is adapted to the shape of the second opening, and is disposed over the second opening; Atomizing plate, wherein the atomizing plate is disposed at the bottom of the cover plate; and A handle is provided on the top of the cover plate.

[0010] In one embodiment, the olfactory rehabilitation training device further includes a flow guiding component located within the active cavity and connected to the first communication port, for guiding the atomized gas downwards.

[0011] In one embodiment, the flow guiding component includes: A flow guide seat is disposed at the bottom of the base and forms a third connecting port and multiple flow guide cavities. The third connecting port communicates with the first connecting port, and the multiple flow guide cavities are arranged around the third connecting port and are respectively communicated with the third connecting port; and Multiple guide columns are arranged at intervals along the circumference of the movable cavity, with one end of each guide column communicating with a guide cavity and the other end of each guide column facing the bottom wall of the movable cavity.

[0012] In one embodiment, the cover is provided with a liquid injection port, and the top of the first seat is provided with a liquid inlet communicating with the liquid storage cavity, and the liquid injection port is aligned and communicated with the liquid inlet.

[0013] In one embodiment, a detection sensor is provided inside the active cavity for detecting the concentration of atomized gas inside the active cavity; The cover is equipped with a display element, which is connected to the detection sensor to display the concentration of atomized gas.

[0014] In one embodiment, the olfactory rehabilitation training device further includes an adjustment component disposed on the top of the top cover assembly, which is used to adjust the vibration frequency of the atomizing element and / or the air intake of the atomizing chamber.

[0015] In one embodiment, the olfactory rehabilitation training device is configured such that the atomization speed of the atomizing element is not less than the liquid supply speed from the reservoir to the atomizing chamber.

[0016] The technical solution of this invention arranges the liquid storage chamber and the atomizing chamber side by side on the top cover assembly, and connects the atomizing chamber to both the liquid storage chamber and the movable chamber. The atomizing element is placed inside the atomizing chamber, allowing the liquid to be atomized in the liquid storage chamber to flow into the atomizing chamber, where it is directly atomized into gas and input into the movable chamber. This eliminates the need for external piping, reducing the device size and preventing dilution of the atomized gas concentration due to condensation during pipeline transportation. Furthermore, because the atomizing element is located inside the atomizing chamber, it is prevented from being immersed in liquid for extended periods, thus preventing liquid corrosion and ensuring the reliability of the device operation. Attached Figure Description

[0017] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on the structures shown in these drawings without creative effort.

[0018] Figure 1 A schematic diagram of the structure of an embodiment of the olfactory rehabilitation training device provided by the present invention; Figure 2 This is a schematic diagram of the structure of the movable frame in the olfactory rehabilitation training device; Figure 3 This is a structural diagram of the movable frame section in an olfactory rehabilitation training device. Figure 4 An exploded view of the top cover assembly in an olfactory rehabilitation training device; Figure 5 Exploded view of the first body, the second body, and the atomizing component in the olfactory rehabilitation training device; Figure 6 This is a schematic diagram of the flow guiding component in an olfactory rehabilitation training device.

[0019] Explanation of icon numbers: 100. Olfactory Rehabilitation Training Device; 1. Movable Frame; 11. Movable Chamber; 12. Flow Guide Column; 13. Detection Sensor; 14. First Opening; 15. Magnetic Buckle; 2. Top Cover Assembly; 21. Base; 211. Receptacle; 22. Cover; 221. Injection Port; 222. Display Component; 23. First Seat; 231. Second Connecting Port; 232. Liquid Inlet; 233. Liquid Storage Chamber; 24. Second Seat; 241. Atomizing Chamber; 242. Second Opening; 3. Atomizing Component; 31. Cover Plate; 32. Atomizing Sheet; 33. Handle; 4. Flow Guide Assembly; 41. Flow Guide Seat; 411. Third Connecting Port; 412. Flow Guide Chamber; 5. Adjustment Assembly; 51. First Knob; 52. Second Knob.

[0020] The realization of the objective, functional features and advantages of the present invention will be further explained in conjunction with the embodiments and with reference to the accompanying drawings. Detailed Implementation

[0021] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0022] It should be noted that if the embodiments of the present invention involve directional indicators (such as up, down, left, right, front, back, etc.), the directional indicators are only used to explain the relative positional relationship and movement of the components in a specific posture. If the specific posture changes, the directional indicators will also change accordingly.

[0023] Furthermore, if the embodiments of this invention involve descriptions such as "first" or "second," these descriptions are for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined with "first" or "second" may explicitly or implicitly include at least one of those features. Additionally, the use of "and / or" or "and / or" throughout the text includes three parallel solutions. For example, "A and / or B" includes solution A, solution B, or a solution where both A and B are satisfied simultaneously. Furthermore, the technical solutions of the various embodiments can be combined with each other, but this must be based on the ability of those skilled in the art to implement them. When the combination of technical solutions is contradictory or impossible to implement, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection claimed by this invention.

[0024] Olfactory dysfunction is a common complication of various diseases such as rhinitis, Alzheimer's disease, and Parkinson's disease. In order to study the plasticity mechanism of the olfactory center in depth and develop effective rehabilitation strategies accordingly, researchers usually choose mice as experimental animals. By repeatedly exposing mice to target odors in a specific environment, they simulate clinical olfactory rehabilitation training and evaluate the intervention effect.

[0025] In related technologies, there are mainly two types of training devices. One type involves setting up an independent atomizing mechanism outside the mouse's activity chamber, which is connected to the inside of the chamber via a connecting pipe to deliver atomized gas into the mouse's activity chamber. The other type integrates an atomizing plate directly into the bottom of the activity chamber, allowing the atomizing plate to be continuously immersed in liquid, and using the high-frequency vibration of the atomizing plate to atomize the liquid.

[0026] However, both of the above solutions have certain technical drawbacks in practical applications. For the external nebulizer solution, during the process of delivering the atomized gas to the active chamber via tubing, because the tubing temperature is usually lower than the atomization temperature, some aerosol will condense and adhere to the tubing wall surface, resulting in a lower actual gas concentration reaching the chamber and causing deviations in test data. For the bottom-integrated atomizing plate solution, since the atomizing plate needs to be immersed in liquid for a long time, the corrosive components in the liquid will continuously erode the atomizing plate, not only affecting its lifespan but also causing a gradual decrease in atomization efficiency, thus affecting the reliability of rehabilitation training.

[0027] To address the aforementioned issues, this invention proposes an olfactory rehabilitation training device 100, which aims to eliminate the need for external piping and avoid soaking the atomizing sheet 32, thereby reducing its size and ensuring operational reliability.

[0028] Please see Figure 1 , Figure 4 and Figure 5 In one embodiment of the present invention, the olfactory rehabilitation training device 100 includes a movable frame 1, a top cover assembly 2, and an atomizing element 3. The movable frame 1 is provided with a movable cavity 11, and the top of the movable frame 1 is provided with a first opening 14 communicating with the movable cavity 11. The top cover assembly 2 is provided on the first opening 14, and the top cover assembly 2 is provided with a liquid storage cavity 233 and an atomizing cavity 241 side by side. The atomizing cavity 241 is connected to the liquid storage cavity 233 and the movable cavity 11 respectively. The liquid storage cavity 233 can input the liquid to be atomized into the atomizing cavity 241. The atomizing element 3 is provided in the atomizing cavity 241 and is used to atomize the liquid to be atomized.

[0029] In this embodiment, the movable frame 1 serves as the structural basis of the olfactory rehabilitation training device 100, and an movable cavity 11 is formed inside it. This movable cavity 11 provides the experimental mice with the activity space required for olfactory training. A first opening 14 is provided at the top of the movable frame 1, and a top cover assembly 2 is placed over the first opening 14 to close the movable cavity 11. A liquid storage cavity 233 and an atomizing cavity 241 are arranged side by side inside the top cover assembly 2. The liquid storage cavity 233 and the atomizing cavity 241 are interconnected. The liquid to be atomized stored in the liquid storage cavity 233 flows into the atomizing cavity 241. The atomizing cavity 241 is connected to the movable cavity 11, thereby allowing the atomized gas, i.e., aerosol, generated by the atomizing component 3 to be input into the movable cavity 11.

[0030] Understandably, since the liquid storage chamber 233 and the atomizing chamber 241 are arranged side by side and are independent of each other, the atomizing element 3 is installed in the atomizing chamber 241 and is not directly immersed in the liquid to be atomized in the liquid storage chamber 233. The liquid to be atomized slowly flows into the atomizing chamber 241, and the atomizing element 3 atomizes simultaneously, thus avoiding the atomizing element 3 being immersed in the liquid for a long time. This design eliminates the need for external piping, which not only reduces the size of the olfactory rehabilitation training device 100, but also avoids the concentration dilution of the atomized gas due to condensation during pipeline transportation. At the same time, the atomizing element 3 is protected from liquid corrosion, ensuring the reliability of the olfactory rehabilitation training device 100.

[0031] In one embodiment, the side wall of the movable frame 1 is also provided with ventilation holes (not shown) to balance the air pressure inside and outside the movable cavity 11.

[0032] In one embodiment, the first opening 14 is circular, rectangular or other polygonal in shape, and the edge of the top cover assembly 2 is provided with a sealing gasket that matches the first opening 14 to ensure airtightness after the cover is closed.

[0033] In one implementation, please refer to Figure 1 The movable frame 1 and the top cover assembly 2 are connected by magnetic snap fasteners 15.

[0034] In this embodiment, the movable frame 1 and the top cover assembly 2 are detachably and securely connected by a magnetic snap fastener 15. The magnetic snap fastener 15 includes a magnetic component and an attractive component, one of which is located on the top edge of the movable frame 1, and the other is located on the bottom edge of the top cover assembly 2. When the top cover assembly 2 closes onto the first opening 14 from top to bottom, the magnetic component and the attractive component attract each other and engage under the action of magnetic force, thereby fixing the top cover assembly 2 above the movable frame 1 and closing the movable cavity 11.

[0035] Understandably, the detachable connection allows researchers to remove the top cover assembly 2 from the first opening 14 at the top of the movable frame 1 before conducting olfactory training experiments, fully opening the movable cavity 11 and facilitating the placement of the experimental mouse into it from above. During or after the experiment, when it is necessary to clean or replenish the liquid to be atomized in the reservoir 233, or to replace or repair the atomizing element 3, the top cover assembly 2 can be removed, exposing the reservoir 233, atomizing cavity 241, and atomizing element 3 directly to the operating space without moving the movable frame 1.

[0036] In another embodiment, the movable frame 1 and the top cover assembly 2 are connected by threads. The top edge of the movable frame 1 has external threads, and the top cover assembly 2 has corresponding internal threads. The two are sealed by rotation. Alternatively, the top edge of the movable frame 1 is provided with a flange, and the edge of the top cover assembly 2 is provided with elastic claws. By pressing, the claws are engaged under the flange to achieve a sealed connection.

[0037] In one implementation, please refer to Figure 4 and Figure 5 The top cover assembly 2 includes a base 21, a cover 22, a first seat 23, and a second seat 24. The base 21 encloses a receiving groove 211, and the bottom wall of the base 21 covers the first opening 14. The bottom wall of the base 21 has a first connecting port. The cover 22 covers the opening of the receiving groove 211. The first seat 23 is located in the receiving groove 211 and encloses a liquid storage chamber 233. The side wall of the first seat 23 has a second connecting port 231 that communicates with the liquid storage chamber 233. The second seat 24 is located in the receiving groove 211 and is connected to the first seat 23. The second seat 24 encloses an atomizing chamber 241. The atomizing chamber 241 communicates with the liquid storage chamber 233 through the second connecting port 231 and with the movable chamber 11 through the first connecting port.

[0038] In this embodiment, the base 21 serves as the structural foundation of the top cover assembly 2. The bottom wall of the base 21 directly covers the first opening 14 at the top of the movable frame 1, thereby suspending the entire receiving groove 211 above the movable cavity 11. A first connecting port is opened on the bottom wall of the base 21, and the position of the first connecting port corresponds to the atomizing cavity 241 formed by the second seat 24, thereby connecting the atomizing cavity 241 with the movable cavity 11. The cover 22 covers the opening at the top of the receiving groove 211 to close the upper end of the receiving groove 211. The first seat 23 and the second seat 24 are arranged side by side in the receiving groove 211. The first seat 23 forms a liquid storage cavity 233, and the second seat 24 forms an atomizing cavity 241. The two cavities are independent of each other and arranged adjacent to each other. The side wall of the first seat 23 has a second communication port 231, and the position of the second communication port 231 corresponds to the atomizing cavity 241 formed by the second seat 24, thereby connecting the liquid storage cavity 233 and the atomizing cavity 241. The atomizing cavity 241 is connected to the movable cavity 11 through the first communication port, and to the liquid storage cavity 233 through the second communication port 231.

[0039] Specifically, the second connecting port 231 adopts a microporous structure, meaning that the pore size of the second connecting port 231 is much smaller than the pore size of a conventional pipe opening, and includes multiple such microporous structures. Understandably, through the surface tension and flow resistance generated by the microporous structure, the liquid in the liquid storage chamber 233 seeps into the atomizing chamber 241 at a slow and stable speed.

[0040] In one embodiment, the aperture of the second communication port 231 can be set to 0.1mm to 2mm. The specific value can be adjusted according to the actual situation and is not specifically limited here.

[0041] In one embodiment, a plurality of second communication ports 231 are spaced apart along a straight line on the side wall of the first base 23, or the plurality of second communication ports 231 are arranged in a honeycomb, grid, or concentric circle pattern.

[0042] In another embodiment, the second communication port 231 adopts a slit structure, a capillary array, or a porous ceramic sheet structure to limit the flow rate of the liquid to be atomized.

[0043] In one implementation, please refer to Figure 1 and Figure 4 The olfactory rehabilitation training device 100 also includes an adjustment component 5, which is located on the top of the top cover component 2 and is used to adjust the vibration frequency of the atomizing element 3 and / or the air intake of the atomizing chamber 241.

[0044] In this embodiment, the adjustment component 5 is located on top of the top cover component 2, allowing experimenters to operate it directly during the operation of the olfactory rehabilitation training device 100 without disassembling the top cover component 2 or interrupting the training process. The adjustment component 5 is electrically connected to both the atomizing element 3 and the external airway control unit, thereby enabling dynamic control of the atomization parameters. Specifically, the adjustment of the vibration frequency by the adjustment component 5 directly determines the particle size distribution of the aerosol generated by the atomizing element 3, while the adjustment of the air intake determines the total amount of atomized gas input into the active cavity 11 per unit time. These two aspects work together to allow experimenters to flexibly configure the physical characteristics of the aerosol stimulation according to the specific disease model and training stage.

[0045] Specifically, the adjustment component 5 includes a first knob 51 and a second knob 52. The first knob 51 is electrically connected to the second base 24. When the atomizing element 3 is inserted into the atomizing chamber 241, the electrode lead of the atomizing element 3 is connected to the control circuit corresponding to the first knob 51 through elastic contacts or pins. The circuit is automatically turned on. The first knob 51 can control the vibration frequency of the atomizing element 3, thereby changing the particle size of the aerosol.

[0046] The olfactory rehabilitation training device 100 also includes a pump body (not shown) and an air intake pipe (not shown). The pump body is mounted on the movable frame 1. The air intake pipe connects the atomizing chamber 241 and the pump body, and the connection point between the air intake pipe and the atomizing chamber 241 is higher than the bottom liquid level of the atomizing chamber 241. The pump body is electrically connected to a second knob 52, which adjusts the air intake of the atomizing chamber 241 by adjusting the output power of the pump body.

[0047] The first knob 51 adjusts the vibration frequency of the atomizing element 3 by changing the frequency of the electrical signal applied to it. When the vibration frequency increases, the liquid film on the surface of the atomizing element 3 breaks down more severely, and the aerosol particle size decreases accordingly. When the vibration frequency decreases, the liquid film breaks down more gently, and the aerosol particle size increases accordingly.

[0048] The second knob 52 adjusts the output power of the pump, thereby changing the airflow rate pumped into the atomizing chamber 241. After entering the atomizing chamber 241, the airflow mixes with the aerosol generated by the atomizing element 3, and the mixed aerosol is pushed into the active chamber 11 through the first connecting port. A larger airflow rate results in more atomized gas entering the active chamber 11 per unit time, leading to a higher aerosol density; conversely, a smaller airflow rate results in a lower aerosol density. Through the independent adjustment of the first knob 51 and the second knob 52, the experimenter can control the aerosol particle size and output flow rate separately, achieving independent control of both parameters.

[0049] Understandably, when the first knob 51 increases the atomization speed and generates more aerosol, the experimenter can increase the air intake using the second knob 52. This allows the airflow to promptly push the aerosol generated in the atomization chamber 241 into the active chamber 11 through the first connecting port, preventing the aerosol from stagnating or flowing back into the atomization chamber 241. When the first knob 51 decreases the atomization speed, the air intake can be reduced accordingly to maintain a stable aerosol density in the active chamber 11. Through the coordinated adjustment of the first knob 51 and the second knob 52, it is ensured that the liquid entering the atomization chamber 241 can be atomized in a timely manner, and that the atomized gas can be smoothly output, preventing liquid from flowing directly into the active chamber 11 from the first connecting port and preventing liquid accumulation in the atomization chamber 241.

[0050] Specifically, in upper respiratory tract inflammation models such as allergic rhinitis, olfactory dysfunction mainly stems from inflammatory swelling and increased secretions in the anterior nasal mucosa. The training aims to promote mucosal surface repair through the humidification and mechanical stimulation of large-particle aerosols. Therefore, the experimenters need to adjust the first knob 51 towards a lower frequency to reduce the vibration frequency of the atomizer 3, thereby increasing the diameter of the aerosol. At this time, the aerosol mainly deposits in the nasal vestibule and middle nasal meatus region, creating a high-humidity environment locally and exerting humidification and anti-inflammatory effects. Simultaneously, the experimenters can adjust the second knob 52 to a medium or high air intake setting according to the training intensity requirements, allowing the pump to pump sufficient gas into the atomizing chamber 241, ensuring a high aerosol density within the active chamber 11, and ensuring that the experimental mice can fully contact the large-particle aerosols during respiration.

[0051] In models of central neurodegenerative diseases such as Alzheimer's or Parkinson's, olfactory dysfunction is closely related to synaptic degeneration of neurons in the olfactory epithelium and olfactory bulb. The training aims to deposit odor molecules in the olfactory epithelium at the back of the nasal cavity, activating the olfactory bulb and higher olfactory centers, and inducing synaptic plasticity. Therefore, the experimenters need to adjust the first knob 51 towards a higher frequency to increase the vibration frequency of the atomizer 3, thereby reducing the diameter of the aerosol. At this time, the aerosol can pass through the front of the nasal cavity with the airflow and reach the olfactory cleft and olfactory epithelium at the top of the nasal cavity for targeted deposition. At the same time, to avoid excessively high aerosol density in the active cavity 11 causing respiratory discomfort in the experimental mice, the experimenters can adjust the second knob 52 to a lower air intake setting, allowing the pump to supply gas to the atomizer 241 at a smaller flow rate, maintaining the aerosol density in the active cavity 11 at a low and constant level, thus achieving long-term, low-intensity continuous olfactory stimulation.

[0052] In one embodiment, the olfactory rehabilitation training device 100 is configured such that the atomization speed of the atomizing element 3 is not less than the liquid supply speed from the liquid storage chamber 233 to the atomizing chamber 241.

[0053] Understandably, when the second connecting port 231 has a microporous structure, under the combined action of multiple microporous structures, the liquid flows from the storage chamber 233 into the atomizing chamber 241 at a stable flow rate. The liquid supply rate at this time is determined by the pore size and number of the microporous structures, remaining relatively constant during a single training session. The rate at which the atomizing element 3 consumes liquid, i.e., the atomization rate, can be adjusted using the first knob 51. The first knob 51 is electrically connected to the atomizing element 3, and by changing the vibration frequency of the atomizing element 3, the amount of liquid atomized per unit time is directly adjusted. When the first knob 51 is adjusted towards a higher frequency, the vibration frequency of the atomizing element 3 increases, the atomization rate increases accordingly, and the aerosol particle size decreases. When the first knob 51 is adjusted towards a lower frequency, the vibration frequency decreases, the atomization rate decreases accordingly, and the aerosol particle size increases. Regardless of the frequency setting of the first knob 51, the atomization speed of the atomizing element 3 must always be no less than the liquid supply speed from the liquid storage chamber 233 to the atomizing chamber 241, so as to form a dynamic balance in the atomizing chamber 241 and avoid liquid accumulation.

[0054] It should be noted that although by configuring the olfactory rehabilitation training device 100 such that the atomization speed of the atomizing element 3 is not less than the liquid supply speed from the liquid storage chamber 233 to the atomizing chamber 241, a dynamic balance can be formed in the atomizing chamber 241, in actual operation, there are still a number of factors that may cause the atomization speed to be temporarily lower than the liquid supply speed. At this time, the liquid accumulated in the atomizing chamber 241 flows directly into the active chamber 11 through the first connecting port, causing the experimental mouse's activity environment to be contaminated or the experimental data to be deviated.

[0055] To solve the above problems, in one embodiment, a column protrudes into the bottom wall of the atomizing chamber 241, and a first connecting port extends through the column along the extension direction of the column, so that the atomizing chamber 241 is an annular groove structure, and the liquid and the atomizing element 3 are arranged around the central column. In this way, the height of the first connecting port is higher than the bottom wall of the atomizing chamber 241, thereby avoiding liquid leakage.

[0056] Specifically, the central region of the bottom wall of the second seat 24 protrudes into the atomizing chamber 241 to form a column. The first connecting port penetrates the column along its axial direction, creating a through channel inside the column. The upper end of this through channel connects to the interior of the atomizing chamber 241, and the lower end connects to the movable chamber 11. Because the column protrudes upwards from the bottom wall of the atomizing chamber 241, a height difference is created between the first connecting port and the bottom wall of the atomizing chamber 241. The bottom wall of the atomizing chamber 241 is recessed around the column to form an annular groove. After the atomized liquid flows into the atomizing chamber 241 through the second connecting port 231, it accumulates in the bottom region of the annular groove. The atomizing element 3 is installed in the annular groove and surrounds the column, with its working surface in contact with the accumulated liquid. When the liquid level in the atomizing chamber 241 is lower than the top of the column, the liquid cannot reach the inlet of the first connecting port and is thus confined within the annular groove, preventing liquid leakage.

[0057] In one implementation, please refer to Figure 4 and Figure 5 The top of the second seat 24 is provided with a second opening 242 that communicates with the atomizing chamber 241, and the atomizing component 3 is detachably inserted into the atomizing chamber 241 through the second opening 242.

[0058] In this embodiment, the top of the second seat 24 is provided with a second opening 242 for inserting the atomizing element 3 vertically into the atomizing cavity 241, so that the working surface of the atomizing element 3 is suspended in the atomizing cavity 241 and in contact with the liquid flowing in through the second connecting port 231.

[0059] Understandably, once the atomizing element 3 is inserted into place, its outer wall fits snugly against the edge of the second opening 242, thus ensuring that the atomizing element 3 is stably housed within the atomizing chamber 241. When it is necessary to replace or clean the atomizing element 3, the experimenter can simply pull it out.

[0060] In one embodiment, the outer wall of the atomizing element 3 is provided with external threads, and the inner wall of the second opening 242 is provided with corresponding internal threads, achieving fastening by rotation. Alternatively, the outer wall of the atomizing element 3 is provided with elastic claws, and the inner wall of the second opening 242 is provided with an annular groove. After the atomizing element 3 is inserted into the atomizing cavity 241, the elastic claws spring into the annular groove to achieve axial limiting. Alternatively, the second opening 242 is provided with a stepped surface, allowing the atomizing element 3 to directly overlap the stepped surface when inserted into the atomizing cavity 241.

[0061] In one implementation, please refer to Figure 5 The atomizing component 3 includes a cover plate 31, an atomizing plate 32, and a handle 33. The shape of the cover plate 31 is adapted to the shape of the second opening 242 and is placed over the second opening 242. The atomizing plate 32 is located at the bottom of the cover plate 31, and the handle 33 is located at the top of the cover plate 31.

[0062] In this embodiment, the outer contour of the cover plate 31 is adapted to the shape of the second opening 242. A stepped surface is provided at the second opening 242. When the atomizing element 3 is inserted into the second opening 242, the edge of the cover plate 31 fits against the stepped surface of the second opening 242, thereby sealing the second opening 242 and preventing the atomized gas in the atomizing chamber 241 from escaping upwards from the second opening 242. The atomizing plate 32 is fixed to the bottom of the cover plate 31 and located on the side of the cover plate 31 facing the atomizing chamber 241. The atomizing plate 32 is stably suspended in the atomizing chamber 241 by the cover plate 31 without the need for additional support structures. A handle 33 is provided at the top of the cover plate 31, i.e., on the side of the cover plate 31 facing away from the atomizing chamber 241, facilitating the experimenter to pull the atomizing element 3 out of or press it into the second opening 242.

[0063] In one embodiment, the atomizing plate 32 is circular, square, or irregularly shaped, and no specific limitation is made here.

[0064] In one embodiment, the atomizing plate 32 is a microporous atomizing plate 32, an ultrasonic vibrating plate, or a piezoelectric ceramic atomizing plate 32. When the atomizing plate 32 is a microporous atomizing plate 32, it is installed at the bottom of the cover plate 31 with the microporous area facing the interior of the atomizing cavity 241. Liquid flowing into the atomizing cavity 241 through the second connecting port 231 forms a liquid film on the surface of the micropores. The microporous atomizing plate 32 vibrates at high frequency under the drive of an electrical signal, breaking the liquid film into aerosols. When the atomizing plate 32 is an ultrasonic vibrating plate, high-frequency ultrasonic energy can generate a cavitation effect on the liquid surface, causing the liquid surface to bulge and break into aerosols. When the atomizing plate 32 is a piezoelectric ceramic atomizing plate 32, the inverse piezoelectric effect of the piezoelectric material can be used to generate high-frequency mechanical vibration, directly acting on the liquid film to achieve atomization.

[0065] In one embodiment, a plurality of atomizing plates 32 are arranged side by side at the bottom of the cover plate 31. The plurality of atomizing plates 32 have the same pore size, thereby improving atomization efficiency. Alternatively, the plurality of atomizing plates 32 have different pore sizes, allowing the experimenter to select the appropriate atomizing plate 32 for operation according to the particle size requirements of the aerosol.

[0066] In one implementation, please refer to Figure 1 , Figure 4 and Figure 5 The cover 22 is provided with a liquid injection port 221, and the top of the first seat 23 is provided with a liquid inlet 232 that communicates with the liquid storage chamber 233. The liquid injection port 221 and the liquid inlet 232 are aligned and communicated.

[0067] In this embodiment, the injection port 221 is located on the cover 22 and is used to replenish the liquid to be atomized into the storage chamber 233. Simultaneously, the top of the first base 23 has an inlet 232 that communicates with the storage chamber 233. When the cover 22 is closed onto the opening of the receiving groove 211, the injection port 221 and the inlet 232 are vertically aligned and connected, facilitating the injection of the prepared liquid to be atomized into the storage chamber 233 using a pipette or syringe. Furthermore, a sealing plug (not shown) is provided at the injection port 221. After the liquid to be atomized is injected into the storage chamber 233 through the injection port 221, the sealing plug is inserted into the injection port 221 to isolate the storage chamber 233 from the external environment, preventing atomized gas from escaping from the injection port 221 during training and avoiding external contaminants from entering the storage chamber 233.

[0068] In one implementation, please refer to Figure 1 , Figure 3 and Figure 4 The movable cavity 11 is equipped with a detection sensor 13 for detecting the concentration of atomized gas in the movable cavity 11; the cover 22 is equipped with a display 222, which is connected to the detection sensor 13 for displaying the concentration of atomized gas.

[0069] In this embodiment, the detection sensor 13 is installed on the side wall of the active cavity 11, with its detection end facing the interior space of the active cavity 11, for real-time acquisition of the concentration information of the atomized airflow within the active cavity 11. Simultaneously, a display 222 is embedded in the surface of the cover 22. The display 222 is connected to the detection sensor 13 via a cable or wireless transmission module, capable of receiving and processing electrical signals from the detection sensor 13, and ultimately presenting the concentration information of the atomized airflow to the experimenter in numerical or graphical form to determine whether the current training environment meets the experimental requirements.

[0070] In one embodiment, the detection sensor 13 is at least one of a photoelectric turbidity sensor, a laser scattering particulate matter sensor, an infrared absorption gas concentration sensor, and a semiconductor gas sensor.

[0071] In one embodiment, the display 222 is at least one of a liquid crystal display screen, a digital tube, an LED indicator array, and a pointer instrument. In addition to displaying real-time concentration values, the display 222 can also display relevant information such as concentration change curves and cumulative training time.

[0072] In one embodiment, the detection sensor 13 monitors the air density in the active cavity 11 in real time and feeds the signal back to the adjustment component 5. The adjustment component 5 can automatically adjust the pump power corresponding to the second knob 52 according to a preset threshold to maintain the constant air density in the active cavity 11.

[0073] In one implementation, please refer to Figure 2 and Figure 6 The olfactory rehabilitation training device 100 also includes a flow guiding component 4, which is located in the active cavity 11 and connected to the first communication port, for guiding the atomized gas downward.

[0074] In this embodiment, the flow guiding component 4 is installed in the active cavity 11 and communicates with the first communication port on the bottom wall of the base 21, thereby transforming the originally vertically downward sprayed atomized airflow into an airflow pattern that is dispersed circumferentially along the active cavity 11 and diffuses uniformly downward.

[0075] Understandably, guided by the flow guide component 4, the atomized gas will not be concentrated in the central area of ​​the active cavity 11 and directly impact it. Instead, it will be distributed to multiple locations in the active cavity 11 and then slowly sink to the bottom of the active cavity 11. This will make the atomized gas concentration in each area of ​​the active cavity 11 more uniform. At the same time, it will prevent the high-speed atomized gas flow from blowing directly onto the experimental mice and causing stress.

[0076] In one implementation, please refer to Figure 2 and Figure 6 The flow guiding assembly 4 includes a flow guiding seat 41 and a plurality of flow guiding columns 12. The flow guiding seat 41 is located at the bottom of the base 21 and forms a third communication port 411 and a plurality of flow guiding cavities 412. The third communication port 411 is connected to the first communication port. The plurality of flow guiding cavities 412 are arranged around the third communication port 411 and are respectively connected to the third communication port 411. The plurality of flow guiding columns 12 are arranged at intervals along the circumference of the movable cavity 11, and one end of each flow guiding column 12 is connected to a flow guiding cavity 412, and the other end of each flow guiding column 12 is arranged towards the bottom wall of the movable cavity 11.

[0077] In this embodiment, the guide seat 41 is installed below the bottom wall of the base 21. The guide seat 41 has a recessed third connecting port 411, which is a groove structure. The groove of the third connecting port 411 is connected to the first connecting port on the bottom wall of the base 21, so that the atomized airflow output from the atomizing chamber 241 enters the guide seat 41. The guide seat 41 also has multiple guide chambers 412, which are arranged in a ring around the third connecting port 411. These chambers divide the originally vertically downward-spraying single stream of atomized airflow into multiple streams, which are then guided to different circumferential directions. Each guide chamber 412 is connected to a guide column 12. The guide column 12 extends downward from the guide seat 41 to different circumferential positions of the movable chamber 11, and the end opening of each guide column 12 faces the bottom wall of the movable chamber 11, so that the split atomized airflow is ultimately blown towards the bottom wall of the movable chamber 11.

[0078] It should be noted that during actual use, when atomization in the atomization chamber 241 is insufficient or the atomization density is high, some un-atomized droplets will adhere to the bottom wall surface of the third connecting port 411 after flowing into the third connecting port 411 with the airflow. As the training process progresses, the adhered liquid may gradually accumulate on the bottom wall of the third connecting port 411 and, driven by subsequent airflow, flow along the bottom wall of the third connecting port 411 to the surrounding guide chambers 412. Once the liquid flows into the guide chambers 412, it may further flow downward along the guide column 12 and eventually enter the activity chamber 11, thereby contaminating the experimental mouse's activity environment and affecting the accuracy of the experimental data.

[0079] To address the aforementioned issues, in one embodiment, the bottom wall of the third connecting port 411 is lower than the bottom wall height of the guide cavity 412.

[0080] Specifically, the third connecting port 411 on the top surface of the guide seat 41 is a downwardly recessed countersunk structure. The bottom wall of this countersunk structure is lower than the bottom wall of the guide cavity 412 to create a height difference. Since the bottom wall of the third connecting port 411 is lower than the bottom wall of the guide cavity 412, the flowing liquid first accumulates in the recessed space of the third connecting port 411. The liquid level must rise above the height of the bottom wall of the guide cavity 412 before it can overflow into the guide cavity 412, thereby preventing the liquid from directly entering the active cavity 11.

[0081] In one embodiment, the flow guide seat 41 is integrally formed with the base 21. Alternatively, the flow guide seat 41 can be detachably installed on the bottom of the base 21 by means of snaps, threads, or magnets, so as to facilitate cleaning and replacement.

[0082] In one embodiment, the guide column 12 extends vertically downward along the sidewall of the active cavity 11, or it may extend obliquely downward. Simultaneously, the end opening of the guide column 12 may be configured as a slanted cut to further reduce the exhaust velocity and decrease the airflow impact on the experimental mice.

[0083] In another embodiment, the flow guiding component 4 includes an umbrella-shaped baffle suspended below the first connecting port. After the atomized airflow impacts the umbrella-shaped baffle, it slides obliquely along the umbrella surface and then falls evenly in all directions. In this way, the atomized airflow can also be evenly dispersed downwards and in all directions from the first connecting port, thus avoiding direct blowing on the mouse.

[0084] In summary, the process of using this olfactory rehabilitation training device 100 to conduct olfactory rehabilitation training on mice is as follows: First, remove the top cover assembly 2 from the first opening 14 at the top of the movable frame 1 to open the movable cavity 11. Place the experimental mouse to be trained into the movable cavity 11 through the first opening 14. Then, close the top cover assembly 2 to the first opening 14 and fix the top cover assembly 2 to the movable frame 1 in a sealed manner by using the magnetic snap fastener 15.

[0085] The second step is to use a pipette or syringe to inject the prepared liquid into the reservoir 233 through the injection port 221 on the cap 22. After the injection is completed, the injection port 221 is sealed with a sealing rubber stopper to isolate the reservoir 233 from the external environment.

[0086] The third step involves setting training parameters by adjusting component 5 according to the type of disease model to be studied. For example, when training an allergic rhinitis model, the first knob 51 is adjusted to a low-frequency direction, causing the nebulizer 3 to operate at a lower vibration frequency and generate large-particle aerosols. At the same time, the second knob 52 is adjusted to a medium or high air intake setting, causing the pump to pump gas into the nebulization chamber 241 at a larger flow rate, maintaining a high aerosol density in the active chamber 11. When training an Alzheimer's disease or Parkinson's disease model, the first knob 51 is adjusted to a high-frequency direction, causing the nebulizer 3 to operate at a higher vibration frequency and generate small-particle aerosols. At the same time, the second knob 52 is adjusted to a lower air intake setting, causing the pump to pump gas into the nebulization chamber 241 at a smaller flow rate, maintaining a lower aerosol density in the active chamber 11.

[0087] Fourth, the power is turned on. After the atomizing element 3 is powered on, it generates high-frequency vibration, which atomizes the liquid flowing into the atomizing chamber 241. At the same time, after the pump body is powered on, gas is pumped into the atomizing chamber 241. The gas mixes with the aerosol generated by the atomizing element 3 and enters the active chamber 11 through the first connecting port and the flow guiding component 4 for the experimental mice to undergo olfactory training.

[0088] Fifth, during the training process, the detection sensor 13 detects the gas density in the active cavity 11 in real time and transmits the concentration signal to the display 222 for real-time display. The experimenter adjusts the first knob 51 and the second knob 52 based on the displayed data to maintain the stability of the gas density in the active cavity 11.

[0089] Step 6: After a single training session reaches the preset duration, turn off the power, disconnect the top cover assembly 2 from the movable frame 1, remove the top cover assembly 2 from the movable frame 1, and take out the experimental mouse.

[0090] Step 7: After training, disassemble and clean the first seat 23, the second seat 24, the movable frame 1, the atomizing component 3, and the flow guide seat 41. If necessary, pull out the atomizing component 3 and replace the atomizing plate 32.

[0091] The above description is merely an exemplary embodiment of the present invention and does not limit the patent scope of the present invention. Any equivalent structural transformations made using the contents of the present invention's specification and drawings under the technical concept of the present invention, or direct / indirect applications in other related technical fields, are included within the patent protection scope of the present invention.

Claims

1. An olfactory rehabilitation training device, characterized in that, The olfactory rehabilitation training device includes: A movable frame, wherein the movable frame is configured to form a movable cavity, and the top of the movable frame is provided with a first opening communicating with the movable cavity; A top cover assembly, wherein the top cover assembly covers the first opening, and the top cover assembly has a liquid storage chamber and an atomizing chamber arranged side by side, the atomizing chamber communicating with the liquid storage chamber and the movable chamber respectively, and the liquid storage chamber being able to input the liquid to be atomized into the atomizing chamber; and An atomizing element is disposed within the atomizing chamber and is used to atomize the liquid to be atomized.

2. The olfactory rehabilitation training device as described in claim 1, characterized in that, The top cover assembly includes: A substrate, wherein the substrate is enclosed to form an accommodating groove, the bottom wall of the substrate covers the first opening, and the bottom wall of the substrate is provided with a first communicating port; A cover body, the cover body being disposed over the opening of the receiving groove; A first seat, disposed within the receiving groove and surrounding the liquid storage cavity, wherein the side wall of the first seat is provided with a second communication port communicating with the liquid storage cavity; and The second seat is disposed in the receiving groove and connected to the first seat. The second seat surrounds and forms the atomizing cavity. The atomizing cavity is connected to the liquid storage cavity through the second connecting port and to the movable cavity through the first connecting port.

3. The olfactory rehabilitation training device as described in claim 2, characterized in that, The top of the second seat is provided with a second opening that communicates with the atomizing chamber, and the atomizing element is detachably inserted into the atomizing chamber through the second opening.

4. The olfactory rehabilitation training device as described in claim 3, characterized in that, The atomizing element includes: A cover plate, the shape of which is adapted to the shape of the second opening, and is disposed over the second opening; Atomizing plate, wherein the atomizing plate is disposed at the bottom of the cover plate; and A handle is provided on the top of the cover plate.

5. The olfactory rehabilitation training device as described in claim 2, characterized in that, The olfactory rehabilitation training device also includes a flow guiding component, which is located inside the active cavity and connected to the first communication port, for guiding the atomized gas downward.

6. The olfactory rehabilitation training device as described in claim 5, characterized in that, The flow guiding component includes: A flow guide seat is disposed at the bottom of the base and forms a third connecting port and multiple flow guide cavities. The third connecting port communicates with the first connecting port, and the multiple flow guide cavities are arranged around the third connecting port and are respectively communicated with the third connecting port; and Multiple guide columns are arranged at intervals along the circumference of the movable cavity, with one end of each guide column communicating with a guide cavity and the other end of each guide column facing the bottom wall of the movable cavity.

7. The olfactory rehabilitation training device as described in claim 2, characterized in that, The cover is provided with a liquid injection port, and the top of the first seat is provided with a liquid inlet that communicates with the liquid storage cavity. The liquid injection port is aligned and communicates with the liquid inlet.

8. The olfactory rehabilitation training device as described in claim 2, characterized in that, The active chamber is equipped with a detection sensor for detecting the concentration of atomized gas within the active chamber; The cover is equipped with a display element, which is connected to the detection sensor to display the concentration of atomized gas.

9. The olfactory rehabilitation training device according to any one of claims 1 to 8, characterized in that, The olfactory rehabilitation training device also includes an adjustment component located on the top of the top cover assembly, used to adjust the vibration frequency of the atomizing element and / or the air intake of the atomizing chamber.

10. The olfactory rehabilitation training device according to any one of claims 1 to 8, characterized in that, The olfactory rehabilitation training device is configured such that the atomization speed of the atomizing element is not less than the liquid supply speed from the liquid storage chamber to the atomizing chamber.

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