A device for preparing forest frog ovary peptide enteric microspheres

Abstract

The application relates to the technical field of medicine preparation, in particular to a ranae ovata peptide enteric microsphere preparation device which comprises a support frame, a tank body is arranged on the support frame, a discharging pipe is embedded at the bottom end of the tank body, a film plating assembly for wrapping microspheres is arranged at the top end of the support frame, the film plating assembly comprises an emulsifying tank which is installed on the support frame, a pump body is installed at the top end of the emulsifying tank, a liquid inlet pipe is arranged at the output end of the pump body, a guide circular ring is connected to one end of the liquid inlet pipe and arranged on a filter screen frame one, a plurality of shunt pipes are arranged at the lower end of the guide circular ring and extend to the inner bottom wall, a film plating flow channel is arranged between a film plating hole one and a film plating hole two, the cross sections of the film plating hole one and the film plating hole two are arranged in a conical shape, the shunt pipes arranged on the filter screen frame one extend into a filter screen frame two, the preparation efficiency and the finished product quality are greatly improved by synchronously completing the fractional screening and the enteric film plating, and the problems of uneven coating and missing coating in the traditional mode are effectively solved.

Description

Technical Field

[0001] This invention relates to the field of drug preparation technology, specifically to a device for preparing enteric-coated microspheres of frog egg peptides. Background Technology

[0002] Forest frog egg peptides are a type of bioactive polypeptide with high medicinal value, but their stability is poor. Direct oral administration is easily destroyed and degraded by gastric acid, resulting in low bioavailability. Therefore, they are often prepared into enteric-coated microspheres to achieve targeted release and protect their activity. Existing devices for preparing enteric-coated microspheres of frog ovpeptide have significant defects in the microsphere forming process: the microspheres are formed by single spraying or direct immersion, along with a stirring device. This method results in poor coating uniformity, and the microspheres are prone to localized over-thickness, under-thickness, or even leakage, making it difficult to guarantee the enteric coating effect. Therefore, it is necessary to propose a device for preparing enteric-coated microspheres of frog ovpeptide. Summary of the Invention

[0003] To address the problems in the prior art, the present invention provides a device for preparing enteric-coated microspheres of frog egg peptides.

[0004] The technical solution adopted by the present invention to solve its technical problem is: a device for preparing enteric-coated microspheres of frog egg peptide, including a support frame, a tank on the support frame, a discharge pipe embedded at the bottom of the tank, cylinders on both sides of the top of the support frame, connecting ears fixedly connected to the output end of cylinders, connecting rings fixedly connected between the connecting ears, a filter frame on the inner end of the connecting ring, a filter frame on the outer end of filter frame, a filter frame on the inner bottom wall of filter frame and filter frame, a plurality of coating holes 1 and coating holes 2 are opened in the filter frame and filter frame 1, crescent-shaped elastic sheets are embedded at the lower ends of both sides of the outer wall of filter frame 1, and a limit ring is fixedly connected to the upper end of the inner frame of filter frame 2; The top of the support frame is provided with a coating assembly for wrapping microspheres. The coating assembly includes an emulsification tank installed on the support frame. A pump body is installed at the top of the emulsification tank. The output end of the pump body is provided with an inlet pipe. One end of the inlet pipe is connected to a guide ring provided on a filter screen frame. The lower end of the guide ring is provided with multiple diversion pipes, which extend to the inner bottom wall. A coating flow channel is opened between the first coating hole and the second coating hole.

[0005] Specifically, a constant temperature jacket is fitted onto the lower end of the outer wall of the tank.

[0006] Specifically, a bracket is installed on the top edge of the support frame, a second cylinder is embedded in the bracket, a can lid is fixedly connected to the output end of the second cylinder, feed pipes are embedded on both sides of the top of the can lid, a servo motor is installed in the middle of the top of the can lid, and a stirring rod is fixedly connected to the output end of the servo motor.

[0007] Specifically, the bottom of the can lid is provided with a sealing ring, and the can lid is located at the opening end of the can body through the sealing ring.

[0008] Specifically, a protective sleeve is provided at one outer end of the cylinder, and the protective sleeve is located on the outer wall of the tank.

[0009] Specifically, the diameter of the second coating hole is larger than the diameter of the first coating hole.

[0010] Specifically, the arc-shaped surface of the crescent-shaped elastic sheet corresponds to the limiting ring, and the crescent-shaped elastic sheet is hollow. The filter frame two has a through hole at the crescent-shaped elastic sheet.

[0011] Specifically, the first and second coating holes are tapered in cross-section, the diverter tube on the first filter frame extends into the second filter frame, and there is a redundant section in the diverter tube between the first and second filter frames.

[0012] The first beneficial effect of this invention is that the device uses a cylinder to drive the double-layer filter frame to rise and fall, allowing for flexible switching between grading and coating and maintenance / disassembly states, making it more convenient to use. The use of a tapered coating hole structure (smaller at the top and larger at the bottom) effectively increases the contact probability between the microspheres and the coating solution, resulting in more thorough and uniform coating. Simultaneously, the interlocking structure of the crescent-shaped elastic sheet and the limiting ring enables rapid assembly and disassembly of the second filter frame without requiring overall disassembly, reducing cleaning and maintenance difficulty and ensuring continuous and efficient microsphere grading and coating operations, making it more suitable for large-scale production needs.

[0013] The second beneficial effect of this invention is that, through the cooperation of an emulsification tank, a pump body, and a ring-shaped distribution pipeline, the enteric coating emulsion can be stably delivered to the coating channel, forming a uniform liquid film on the conical orifice wall, enabling microspheres to be coated while moving, resulting in a more stable coating effect. The distribution pipeline has a reserved redundant section to accommodate the lifting and lowering of the filter frame, avoiding pipeline damage from pulling and ensuring a continuous and reliable liquid supply. The device completes the grading and screening and enteric coating simultaneously, significantly improving preparation efficiency and product quality, and effectively improving the problems of uneven coating and leakage in traditional methods. Attached Figure Description

[0014] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0015] Figure 1 This is a schematic diagram of the structure of a device for preparing enteric-coated microspheres of frog egg peptides provided by the present invention; Figure 2 This is a schematic cross-sectional view of the overall structure of the apparatus for preparing enteric-coated microspheres of frog egg peptide provided by the present invention; Figure 3 This invention provides a device for preparing enteric-coated microspheres of frog egg peptides. Figure 2 Enlarged structural diagram at point A in the middle; Figure 4This is a schematic cross-sectional view of the coating pore structure of a device for preparing enteric-coated microspheres of frog egg peptides provided by the present invention; Figure 5 This is a schematic diagram of the top planar structure of the filter frame of a device for preparing enteric-coated microspheres of frog egg peptides provided by the present invention; Figure 6 This invention provides a device for preparing enteric-coated microspheres of frog egg peptides. Figure 5 Enlarged structural diagram at point B.

[0016] In the diagram: 1. Support frame; 2. Bracket; 10. Thermostatic jacket; 11. Tank body; 12. Discharge pipe; 13. Cylinder 1; 14. Connecting ear; 15. Connecting ring; 16. Filter frame 1; 17. Filter frame 2; 21. Cylinder 2; 22. Tank cover; 23. Feed pipe; 24. Servo motor; 25. Stirring rod; 3. Coating assembly; 31. Emulsifying tank; 32. Pump body; 33. Liquid inlet pipe; 34. Guide ring; 35. Diverter pipe; 106. Coating hole 1; 107. Coating hole 2; 108. Through hole; 160. Crescent-shaped elastic sheet; 170. Limiting ring; 301. Coating flow channel. Detailed Implementation

[0017] To make the technical means, creative features, objectives and effects of this invention easier to understand, the invention will be further described below in conjunction with specific embodiments.

[0018] like Figures 1-6 As shown, the present invention provides the following technical solution: Example 1: A device for preparing enteric-coated microspheres of frog egg peptides includes a support frame 1, a tank 11 on the support frame 1, a discharge pipe 12 embedded at the bottom of the tank 11, a constant temperature jacket 10 fitted at the lower end of the outer wall of the tank 11, a bracket 2 installed at the top edge of the support frame 1, a cylinder 21 embedded on the bracket 2, a tank cover 22 fixedly connected to the output end of the cylinder 21, feed pipes 23 embedded on both sides of the top of the tank cover 22, a servo motor 24 installed in the middle of the top of the tank cover 22, a stirring rod 25 fixedly connected to the output end of the servo motor 24, a sealing ring at the bottom of the tank cover 22, and the tank cover 22 is located at the opening end of the tank 11 through the sealing ring.

[0019] The thermostatic jacket 10 is a double-layer jacket structure that wraps around the outside of the tank body 11. A circulating thermostatic medium can be introduced into the jacket for temperature control inside the tank body 11, and it is equipped with a thermostat (existing technology).

[0020] In use, the can lid 22 is first closed and sealed by cylinder 21, and then frog egg peptide raw material and reaction reagents are added into the can body 11 through the feed pipe 23. The constant temperature jacket 10 maintains a constant temperature environment, and the servo motor 24 drives the stirring rod 25 to stir and emulsify the material at a uniform speed to obtain microsphere precursor liquid. The prepared microspheres will be discharged to the next process through the discharge pipe 12. When maintenance and cleaning are required, the can lid 22 is lifted by cylinder 21 to clean and maintain the inside of the can body 11 and the stirring components.

[0021] Example 2: The technical solution of this example, which differs from Example 1, includes: cylinders 13 are provided on both sides of the top of the support frame 1; connecting ears 14 are fixedly connected to the output end of cylinders 13; connecting rings 15 are fixedly connected between the connecting ears 14; a filter frame 16 is provided inside the connecting ring 15; a filter frame 17 is sleeved on the outer end of the filter frame 16; several coating holes 106 and 107 are opened on the inner bottom wall of the filter frame 16 and the filter frame 16; the outer wall of the filter frame 16... The lower ends of both sides are fitted with crescent-shaped elastic sheets 160. The upper end of the inner frame of the filter frame 17 is fixedly connected with a limiting ring 170. The outer end of the cylinder 13 is provided with a protective sleeve, which is located on the outer wall of the tank 11. The diameter of the second coating hole 107 is larger than the diameter of the first coating hole 106. The arc surface of the crescent-shaped elastic sheet 160 corresponds to the limiting ring 170, and the crescent-shaped elastic sheet 160 is hollow. The filter frame 17 is provided with a through hole 108 at the location of the crescent-shaped elastic sheet 160.

[0022] The crescent-shaped elastic sheet 160 and the through hole 108 enable the filter frames one and two to be detachable. When the crescent-shaped elastic sheet 160 is pressed, the elastic surface of the crescent-shaped elastic sheet 160 will retract into the installation groove of the crescent-shaped elastic sheet 160, and no movement interference will be formed. A coating aperture that is smaller at the top and larger at the bottom can increase the probability of coating microspheres.

[0023] In use, when graded coating is required, the cylinders 13 on both sides of the support frame 1 are activated. The output end of cylinder 13 drives filter frames 16 and 27 to descend into place via connecting lugs 14 and connecting rings 15. Filter frames 16 and 27 adopt tapered coating holes that are smaller at the top and larger at the bottom, which can significantly increase the contact probability between the microspheres and the coating solution, and improve the coating effect and uniformity. When disassembly and maintenance are required, control cylinder 13 to drive filter frames 16 and 27 to rise, press the crescent-shaped elastic sheet 160 to disengage it from the limiting ring 170, and filter frame 27 can be quickly removed from filter frame 16. The reversal operation can complete the assembly. There is no need for frequent overall disassembly. The entire process realizes continuous and efficient microsphere grading and coating operations, which meets the needs of large-scale preparation of frog ovpeptide enteric-coated microspheres.

[0024] Example 3: The technical solution of this example, which differs from that of Example 1, includes: a coating assembly 3 for wrapping microspheres is provided at the top of the support frame 1. The coating assembly 3 includes an emulsification tank 31 installed on the support frame 1. A pump body 32 is installed at the top of the emulsification tank 31. An inlet pipe 33 is provided at the output end of the pump body 32. One end of the inlet pipe 33 is connected to a guide ring 34 provided on the first filter frame 16. Multiple diversion pipes 35 are provided at the lower end of the guide ring 34, and the diversion pipes 35 extend to the inner bottom wall. A coating flow channel 301 is opened between the first coating hole 106 and the second coating hole 107. The cross-sections of the first coating hole 106 and the second coating hole 107 are set in a conical shape. The diversion pipes 35 located on the first filter frame 16 extend into the second filter frame 17, and there is a redundant section in the diversion pipes 35 between the first filter frame 16 and the second filter frame 17.

[0025] Among them, the pump body 32, the servo motor 24, and cylinders one and two are connected to an external power supply via a controller; The emulsion tank 31 contains emulsion. The first coating hole 106 and the second coating hole 107 are both conical structures with a smaller top and a larger bottom, which are connected to the coating flow channel 301. This allows the emulsion to spread evenly along the conical hole wall to form a continuous liquid film. When the microspheres pass through, they can be uniformly coated, thus forming a stable enteric emulsion coating layer (the emulsion has viscosity and meets the conditions for coating).

[0026] In use, the enteric coating emulsion in the emulsification tank 31 is pressurized and delivered by the pump body 32, and then evenly fed into the coating channel 301 through the inlet pipe 33, guide ring 34, and diversion pipe 35. Utilizing the tapered coating pore structure of the filter frames 16 and 17 (smaller at the top and larger at the bottom, with gradually changing pore size), the contact probability and coating uniformity between the microspheres and the emulsion are significantly improved. This allows the emulsion to form a stable liquid film on the pore walls, achieving continuous and complete enteric coating of the microspheres. The redundant section of the diversion pipe 35 can accommodate the lifting and lowering displacement of the filter frame 16, avoiding strain on the pipeline, ensuring a stable emulsion supply, and enabling simultaneous and efficient completion of microsphere grading and enteric coating. This effectively improves the molding quality and preparation efficiency of the frog egg peptide enteric microspheres.

[0027] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of protection claimed by the present invention. The scope of protection of the present invention is defined by the appended claims and their equivalents.

Claims

1. A device for preparing enteric-coated microspheres of frog egg peptides, comprising a support frame (1), wherein a tank (11) is provided on the support frame (1), and a discharge pipe (12) is embedded at the bottom end of the tank (11), characterized in that, The support frame (1) has cylinders (13) on both sides at the top. The output end of cylinder (13) is fixedly connected to connecting ears (14). Connecting rings (15) are fixedly connected between connecting ears (14). Filter frame (16) is provided at the inner end of connecting ring (15). Filter frame (17) is sleeved at the outer end of filter frame (16). Several coating holes (106) and coating holes (107) are opened on the inner bottom wall of filter frame (17) and filter frame (16). Half-moon shaped elastic sheets (160) are embedded at the lower ends of the outer walls of filter frame (16). Limiting rings (170) are fixedly connected to the upper end of the inner frame of filter frame (17). The top of the support frame (1) is provided with a coating assembly (3) for wrapping microspheres. The coating assembly (3) includes an emulsification tank (31) installed on the support frame (1). A pump body (32) is installed at the top of the emulsification tank (31). The output end of the pump body (32) is provided with an inlet pipe (33). One end of the inlet pipe (33) is connected to a guide ring (34) provided on a filter screen frame (16). The lower end of the guide ring (34) is provided with multiple diversion pipes (35), and the diversion pipes (35) extend to the inner bottom wall. A coating flow channel (301) is opened between the first coating hole (106) and the second coating hole (107).

2. The apparatus for preparing enteric-coated microspheres of frog egg peptide according to claim 1, characterized in that: The lower end of the outer wall of the tank (11) is fitted with a constant temperature jacket (10).

3. The apparatus for preparing enteric-coated microspheres of frog egg peptide according to claim 1, characterized in that: The support frame (1) has a bracket (2) installed on its top edge. A cylinder (21) is embedded in the bracket (2). The output end of the cylinder (21) is fixedly connected to a can lid (22). Feed pipes (23) are embedded on both sides of the top of the can lid (22). A servo motor (24) is installed in the middle of the top of the can lid (22). A stirring rod (25) is fixedly connected to the output end of the servo motor (24).

4. The apparatus for preparing enteric-coated microspheres of frog egg peptide according to claim 3, characterized in that: The bottom of the can lid (22) is provided with a sealing ring, and the can lid (22) is located at the opening end of the can body (11) through the sealing ring.

5. The apparatus for preparing enteric-coated microspheres of frog egg peptide according to claim 1, characterized in that: The cylinder (13) is provided with a protective sleeve at its outer end, and the protective sleeve is located on the outer wall of the tank (11).

6. The apparatus for preparing enteric-coated microspheres of frog egg peptide according to claim 1, characterized in that: The diameter of the second coating hole (107) is larger than that of the first coating hole (106).

7. The apparatus for preparing enteric-coated microspheres of frog egg peptide according to claim 1, characterized in that: The arc-shaped surface of the crescent-shaped elastic sheet (160) corresponds to the limiting ring (170), and the crescent-shaped elastic sheet (160) is hollow. The filter frame (17) is provided with a through hole (108) at the crescent-shaped elastic sheet (160).

8. The apparatus for preparing enteric-coated microspheres of frog egg peptide according to claim 1, characterized in that: The coating hole one (106) and coating hole two (107) are tapered in cross-section. The diversion pipe (35) located on the filter frame one (16) extends into the filter frame two (17), and there is a redundant section in the diversion pipe (35) between the filter frame one (16) and the filter frame two (17).

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