A sample analyzer

Abstract

The present application relates to a kind of sample analyzers, including identification module, sampling module, liquid drive module, blood sedimentation detection module and controller;When the detection item of the sample to be measured identified by the identification module includes blood sedimentation detection, the controller controls the sampling module to suck the blood sample to be measured, and controls the liquid drive module to drive the blood sample to be measured into the sample pipeline and / or the detection pipeline;The controller is also configured to, in the process that the blood sample to be measured moves from the sample needle to the blood sedimentation detection part, control the blood sedimentation detection component to detect the arrival time of the blood sample to be measured moving to the blood sedimentation detection part, obtain the viscosity information of the blood sample to be measured according to the moving time information containing the arrival time, and determine the disaggregation mode of the blood sample to be measured according to the viscosity information.The sample analyzer can realize the accurate positioning of the detection sample.

Description

Technical Field

[0001] This invention relates to the field of blood sample testing technology, and more particularly to a sample analyzer. Background Technology

[0002] Erythrocyte sedimentation rate (ESR) is a commonly used test in clinical laboratory testing, typically used to reflect the sedimentation characteristics of red blood cells under certain conditions. Existing automated ESR testing equipment usually collects blood samples and uses optical, electrical, or other detection methods to obtain ESR-related data, thereby obtaining the ESR test results.

[0003] In actual testing, the state of blood samples can be affected by various factors, such as sample viscosity, red blood cell aggregation, and sample flow. These factors may affect the sample transport process in the testing flow path and subsequent testing processes, thus impacting the accuracy, stability, or consistency of erythrocyte sedimentation rate (ESR) test results.

[0004] Therefore, existing erythrocyte sedimentation rate (ESR) testing equipment and methods still need further optimization. Summary of the Invention

[0005] To address the shortcomings of existing technologies, the main objective of this invention is to provide a sample analyzer that detects and analyzes the time-series optical signals of the blood sample throughout the entire testing process, enabling rapid estimation of sample viscosity and intelligent monitoring of the liquid path status. Based on this, the analyzer adaptively controls the depolymerization process, thereby improving the system's detection accuracy, reliability, and clinical value with zero hardware cost.

[0006] Therefore, in a first aspect, the present invention provides a sample analyzer, comprising: The identification module is used to identify the detection items of the sample to be tested. The sampling module includes a sample needle, a suction tubing connected to the sample needle, and a sample needle driving device for driving the sample needle to move; one end of the sample needle is used to insert into the sample container to draw the blood sample to be tested from the sample to be tested, and the other end is connected to the suction tubing; A liquid driving module, which is connected to the sample suction line, is used to provide driving force for the flow of fluid within the sample needle and the sample suction line; The erythrocyte sedimentation rate (ESR) detection module includes an ESR detection component; an ESR detection section is configured on the sampling tube or the detection tube connected to the sampling tube, and the ESR detection component is used to detect the blood sample to be tested located on or flowing through the ESR detection section; The controller is configured to control the identification module, sampling module, liquid driving module, and erythrocyte sedimentation rate (ESR) detection module. When the identification module identifies that the test item for the sample to be tested includes erythrocyte sedimentation rate (ESR) testing, the controller controls the sampling module to aspirate the blood sample to be tested and controls the liquid driving module to drive the blood sample to be tested into the aspiration tubing and / or the detection tubing. The controller is further configured to, during the process of the blood sample to be tested moving from the sample needle to the erythrocyte sedimentation rate (ESR) detection unit, control the ESR detection component to detect the arrival time of the blood sample to be tested to the ESR detection unit, obtain the viscosity information of the blood sample to be tested based on the movement time information including the arrival time, and determine the depolymerization mode of the blood sample to be tested based on the viscosity information. The depolymerization mode includes a first depolymerization mode and a second depolymerization mode, and the depolymerization intensity of the first depolymerization mode is different from that of the second depolymerization mode. The controller is also configured to control the liquid driving module to drive the blood sample to be tested to undergo depolymerization processing according to the determined depolymerization mode, and after the depolymerization processing, control the erythrocyte sedimentation rate (ESR) detection component to acquire the aggregation detection data of the blood sample to be tested, and obtain the ESR detection result based on the aggregation detection data.

[0007] In this invention, "depolymerization treatment" refers to a process that reduces the degree of cell aggregation in the blood sample by driving the blood sample to flow and / or reciprocate in the sample flow path, thereby subjecting the blood sample to shearing action. The depolymerization intensity can be characterized by at least one parameter among driving speed, depolymerization time, depolymerization distance, number of reciprocating flows, and single driving volume.

[0008] The sample analyzer of the present invention, wherein the controller determines the deagglomeration mode of the blood sample to be tested based on the viscosity information of the blood sample to be tested, can realize the detection and control of the blood sample to be tested throughout the entire process. By analyzing different characteristics of the same optical signal at different stages (e.g., the deagglomeration process and the aggregation process), multimodal sensing is realized, and the optical detection component in the sample analyzer is upgraded from a single erythrocyte sedimentation rate detection light source to a whole-process "intelligent sensing and control system".

[0009] In some embodiments, the first de-aggregation mode is a conventional de-aggregation mode, and the second de-aggregation mode is an unconventional de-aggregation mode; The unconventional de-aggregation mode includes at least one of a strong de-aggregation mode and a weak de-aggregation mode; The strong depolymerization mode has a greater depolymerization intensity than the conventional depolymerization mode, and the weak depolymerization mode has a lesser depolymerization intensity than the conventional depolymerization mode.

[0010] In some embodiments, the unconventional de-aggregation mode includes the weak de-aggregation mode and the strong de-aggregation mode; The controller is configured to determine the depolymerization mode of the blood sample to be tested based on the viscosity information; when the viscosity information is in a first viscosity range, the blood sample to be tested is determined to correspond to the weak depolymerization mode; when the viscosity information is in a second viscosity range, the blood sample to be tested is determined to correspond to the normal depolymerization mode; and when the viscosity information is in a third viscosity range, the blood sample to be tested is determined to correspond to the strong depolymerization mode. Wherein, the viscosity corresponding to the third viscosity range is greater than the viscosity corresponding to the second viscosity range, and the viscosity corresponding to the second viscosity range is greater than the viscosity corresponding to the first viscosity range.

[0011] In some embodiments, the viscosity corresponding to the second viscosity range is the viscosity of a typical blood sample.

[0012] In some embodiments, the controller stores a correspondence between viscosity ranges and depolymerization modes, and the controller is configured to determine a depolymerization mode that matches the viscosity information based on the correspondence.

[0013] In some embodiments, the controller is configured to determine a depolymerization mode based on the viscosity information of the blood sample to be tested, and control the liquid driving module to drive the blood sample to be tested to flow and / or reciprocate according to the determined depolymerization mode, so as to perform a depolymerization process of corresponding intensity on the blood sample to be tested. The deagglomeration process is used to reduce the degree of cell aggregation in the blood sample to be tested.

[0014] In some embodiments, the liquid driving module is used to drive the blood sample to be tested to flow and / or reciprocate in a sample flow path formed by the sample needle, the aspiration tubing and / or the detection tubing, so as to perform the depolymerization process on the blood sample to be tested.

[0015] In some embodiments, the unconventional de-aggregation mode includes the weak de-aggregation mode and the strong de-aggregation mode; The liquid driving module drives the blood sample to be tested to flow and / or reciprocate according to the weak depolymerization mode, the normal depolymerization mode and the strong depolymerization mode, respectively; The weak depolymerization parameter, the conventional depolymerization parameter, and the strong depolymerization parameter each independently include at least one of the following: driving speed, depolymerization time, depolymerization distance, number of reciprocating flows, and single driving volume; for the same depolymerization parameter, the parameter value of the strong depolymerization parameter is greater than the parameter value of the conventional depolymerization parameter, and the parameter value of the conventional depolymerization parameter is greater than the parameter value of the weak depolymerization parameter.

[0016] In some embodiments, the controller is configured to control the liquid driving module to drive the blood sample to be tested from the sample needle to the erythrocyte sedimentation rate detection unit according to preset driving conditions, and to determine the time when the liquid driving module starts to drive the blood sample to be tested according to the preset driving conditions as the start time; The travel time information includes the time difference between the start time and the arrival time.

[0017] In some embodiments, under the preset driving conditions, the controller obtains the viscosity information of the blood sample to be tested based on the time difference, wherein the larger the time difference, the greater the viscosity of the blood sample to be tested as represented by the viscosity information.

[0018] In some embodiments, the erythrocyte sedimentation rate (ESR) detection component includes a light-emitting element and a light-receiving element, wherein the light-emitting element and the light-receiving element are respectively located on opposite sides of the ESR detection section; The controller is configured to determine the arrival time of the blood sample to be tested to the erythrocyte sedimentation rate (ESR) detection unit based on the time when the change in the light signal received by the light-receiving element meets a preset change condition.

[0019] Therefore, in a second aspect, the present invention provides a method for analyzing blood samples based on the above-mentioned sample analyzer, comprising the following steps: (1) When the identification module identifies that the test item of the sample to be tested includes erythrocyte sedimentation rate (ESR) test, the controller controls the sampling module to aspirate the blood sample to be tested and controls the liquid driving module to drive the blood sample to be tested into the aspiration tube and / or the detection tube; (2) During the process of the blood sample to be tested moving from the sample needle to the erythrocyte sedimentation rate (ESR) detection unit, the controller controls the ESR detection component to detect the arrival time of the blood sample to be tested to the ESR detection unit, obtains the viscosity information of the blood sample to be tested based on the movement time information including the arrival time, and determines the depolymerization mode of the blood sample to be tested based on the viscosity information. The depolymerization mode includes a first depolymerization mode and a second depolymerization mode, and the depolymerization intensity of the first depolymerization mode is different from that of the second depolymerization mode. (3) The controller controls the liquid driving module to drive the blood sample to be tested to perform depolymerization processing according to the determined depolymerization mode, and after the depolymerization processing, controls the erythrocyte sedimentation rate (ESR) detection component to obtain the aggregation detection data of the blood sample to be tested, and obtains the ESR detection result based on the aggregation detection data.

[0020] The beneficial effects of this invention are as follows: First, the sample analyzer of the present invention can achieve precise positioning of the test sample. When different fluids (such as diluent, air, whole blood) flow through the pipeline module, the viscosity is obtained by detecting the fluid flow rate, and the sample can be precisely positioned accordingly.

[0021] Second, the sample analyzer of the present invention can realize viscosity-adaptive depolymerization mode. Different depolymerization modes are determined by detecting the viscosity of the sample. Preferably, a strong depolymerization mode is used for high viscosity samples (e.g., hyperglobulinemia, high HCT), and a mild depolymerization mode is used for low viscosity samples, so as to realize personalized and intelligent processing of the test samples. Attached Figure Description

[0022] Figure 1 This is the relationship between the degree of depolymerization and the shear rate in this invention.

[0023] Figure 2 This is a schematic diagram of the structure of one embodiment of the sample analyzer of the present invention.

[0024] Figure 3 This is a flowchart illustrating an embodiment of erythrocyte sedimentation rate (ESR) detection using the sample analyzer of the present invention.

[0025] Figure 4 The light intensity variations correspond to different fluids in this invention.

[0026] Figure 5 This refers to the change in light intensity when bubbles appear in the sample analyzer of the present invention.

[0027] in, 101. Sampling needle; 102. Drive device; 201. Erythrocyte sedimentation rate (ESR) detection module. Detailed Implementation

[0028] The technical solution of the present invention will be further illustrated below through specific embodiments. Those skilled in the art should understand that the embodiments are merely illustrative of the invention and should not be considered as specific limitations thereof. Where specific conditions are not specified in the embodiments, conventional conditions or conditions recommended by the manufacturer shall apply. Reagents or instruments whose manufacturers are not specified are all commercially available conventional products.

[0029] This invention provides a sample analyzer, which includes: The identification module is used to identify the detection items of the sample to be tested. The sampling module includes a sample needle, a suction tubing connected to the sample needle, and a sample needle driving device for driving the sample needle to move; one end of the sample needle is used to insert into the sample container to draw the blood sample to be tested from the sample to be tested, and the other end is connected to the suction tubing; A liquid driving module, which is connected to the sample suction line, is used to provide driving force for the flow of fluid within the sample needle and the sample suction line; The erythrocyte sedimentation rate (ESR) detection module includes an ESR detection component; an ESR detection section is configured on the sampling tube or the detection tube connected to the sampling tube, and the ESR detection component is used to detect the blood sample to be tested located on or flowing through the ESR detection section; The controller is configured to control the identification module, sampling module, liquid driving module, and erythrocyte sedimentation rate (ESR) detection module. When the identification module identifies that the test item for the sample to be tested includes erythrocyte sedimentation rate (ESR) testing, the controller controls the sampling module to aspirate the blood sample to be tested and controls the liquid driving module to drive the blood sample to be tested into the aspiration tubing and / or the detection tubing. The controller is further configured to, during the process of the blood sample to be tested moving from the sample needle to the erythrocyte sedimentation rate (ESR) detection unit, control the ESR detection component to detect the arrival time of the blood sample to be tested moving to the ESR detection unit, obtain the viscosity information of the blood sample to be tested based on the movement time information including the arrival time, and determine the depolymerization mode of the blood sample to be tested based on the viscosity information. The depolymerization mode includes a first depolymerization mode and a second depolymerization mode, and the depolymerization intensity of the first depolymerization mode is different from that of the second depolymerization mode. The controller is also configured to control the liquid driving module to drive the blood sample to be tested to undergo depolymerization processing according to the determined depolymerization mode, and after the depolymerization processing, control the erythrocyte sedimentation rate (ESR) detection component to acquire the aggregation detection data of the blood sample to be tested, and obtain the ESR detection result based on the aggregation detection data.

[0030] In some embodiments, the first de-aggregation mode is a conventional de-aggregation mode, and the second de-aggregation mode is an unconventional de-aggregation mode; the unconventional de-aggregation mode includes at least one of a strong de-aggregation mode and a weak de-aggregation mode. The strong depolymerization mode has a greater depolymerization intensity than the conventional depolymerization mode, and the weak depolymerization mode has a lesser depolymerization intensity than the conventional depolymerization mode.

[0031] In some embodiments, the unconventional de-aggregation mode includes the weak de-aggregation mode and the strong de-aggregation mode; The controller is configured to determine the depolymerization mode of the blood sample to be tested based on the viscosity information; when the viscosity information is in a first viscosity range, the blood sample to be tested is determined to correspond to the weak depolymerization mode; when the viscosity information is in a second viscosity range, the blood sample to be tested is determined to correspond to the normal depolymerization mode; and when the viscosity information is in a third viscosity range, the blood sample to be tested is determined to correspond to the strong depolymerization mode. Wherein, the viscosity corresponding to the third viscosity range is greater than the viscosity corresponding to the second viscosity range, and the viscosity corresponding to the second viscosity range is greater than the viscosity corresponding to the first viscosity range.

[0032] In some embodiments, the viscosity corresponding to the second viscosity range is the viscosity of a typical blood sample.

[0033] In some embodiments, the viscosity information of the blood sample to be tested is obtained based on a viscosity calculation model, which includes the following steps: S1. The controller acquires the known constants of the sampling module: the driving pressure difference ΔP of the aspiration tube and / or detection tube, the inner diameter R of the aspiration tube and / or detection tube, the tube length L in which pressure drop occurs in the aspiration tube and / or detection tube, the cross-sectional area A of the tube in the aspiration tube and / or detection tube, and the flow velocity v of the blood sample to be tested in the aspiration tube and / or detection tube; S2. Calculate the volumetric flow rate Q of the blood sample to be tested using equation (I); Q = v × A,(I; S3. Calculate the apparent viscosity η of the blood sample to be tested using formula (II); η = (ΔP × π × R 4 ) / (8 × L × Q).

[0034] In some embodiments, the controller stores a correspondence between viscosity ranges and depolymerization modes, and the controller is configured to determine a depolymerization mode that matches the viscosity information based on the correspondence.

[0035] In some embodiments, the controller is configured to determine a depolymerization mode based on the viscosity information of the blood sample to be tested, and control the liquid driving module to drive the blood sample to be tested to flow and / or reciprocate according to the determined depolymerization mode, so as to perform a depolymerization process of corresponding intensity on the blood sample to be tested. The deagglomeration process is used to reduce the degree of cell aggregation in the blood sample to be tested.

[0036] In some embodiments, the liquid driving module is used to drive the blood sample to be tested to flow and / or reciprocate in a sample flow path formed by the sample needle, the aspiration tubing and / or the detection tubing, so as to perform the depolymerization process on the blood sample to be tested.

[0037] In some embodiments, the unconventional de-aggregation mode includes the weak de-aggregation mode and the strong de-aggregation mode; The liquid driving module drives the blood sample to be tested to flow and / or reciprocate according to the weak depolymerization mode, the normal depolymerization mode and the strong depolymerization mode, respectively; The weak depolymerization parameter, the conventional depolymerization parameter, and the strong depolymerization parameter each independently include at least one of the following: driving speed, depolymerization time, depolymerization distance, number of reciprocating flows, and single driving volume; for the same depolymerization parameter, the parameter value of the strong depolymerization parameter is greater than the parameter value of the conventional depolymerization parameter, and the parameter value of the conventional depolymerization parameter is greater than the parameter value of the weak depolymerization parameter.

[0038] Figure 1 The diagram illustrates the relationship between shear rate and the degree of depolymerization. For example... Figure 1 As shown, within a higher shear rate range, the blood sample undergoes stronger shearing, resulting in more thorough dispersion of cell aggregates and a high degree of deagglomeration. When the shear rate decreases to a preset range, the shearing effect weakens, and the degree of deagglomeration decreases with decreasing shear rate. Therefore, by adjusting at least one of the driving parameters of the liquid-driven module—such as driving speed, deagglomeration time, deagglomeration distance, number of reciprocating flows, and single-drive volume—the shearing effect on the blood sample can be altered, thereby achieving deagglomeration treatments of varying intensities. The dashed line in the figure represents the shear rate boundary determined by calibration experiments; its specific value can be set according to sample type, tubing size, and detection conditions.

[0039] In some embodiments, the controller is configured to control the liquid driving module to drive the blood sample to be tested from the sample needle to the erythrocyte sedimentation rate detection unit according to preset driving conditions, and to determine the time when the liquid driving module starts to drive the blood sample to be tested according to the preset driving conditions as the start time; The travel time information includes the time difference between the start time and the arrival time.

[0040] In some embodiments, under the preset driving conditions, the controller obtains the viscosity information of the blood sample to be tested based on the time difference, wherein the larger the time difference, the greater the viscosity of the blood sample to be tested as represented by the viscosity information.

[0041] In some embodiments, the erythrocyte sedimentation rate (ESR) detection component includes a light-emitting element and a light-receiving element, wherein the light-emitting element and the light-receiving element are respectively located on opposite sides of the ESR detection section; The controller is configured to determine the arrival time of the blood sample to be tested to the erythrocyte sedimentation rate (ESR) detection unit based on the time when the change in the light signal received by the light-receiving element meets a preset change condition.

[0042] In a specific example of a sample analyzer, such as Figure 2 As shown, the sampling module includes a sampling needle 101, a driving device 102 for moving the sampling needle 101, and a liquid driving module (not shown) for aspirating the blood sample to be tested and moving it within the tubing to the detection position of the erythrocyte sedimentation rate (ESR) detection module 201. The sampling needle 101 and the liquid driving module are respectively connected to the detection tubing. The sampling needle 101 can move under the drive of the driving device 102 to the blood sample storage and diluent source storage to aspirate the blood sample and diluent respectively. The sample analyzer of the present invention can also perform specific protein, HGB, and routine blood tests.

[0043] The present invention also provides a method for analyzing blood samples based on the above-mentioned sample analyzer, comprising the following steps: (1) When the identification module identifies that the test item of the sample to be tested includes erythrocyte sedimentation rate (ESR) test, the controller controls the sampling module to aspirate the blood sample to be tested and controls the liquid driving module to drive the blood sample to be tested into the aspiration tube and / or the detection tube; (2) During the process of the blood sample to be tested moving from the sample needle to the erythrocyte sedimentation rate (ESR) detection unit, the controller controls the ESR detection component to detect the arrival time of the blood sample to be tested to the ESR detection unit, obtains the viscosity information of the blood sample to be tested based on the movement time information including the arrival time, and determines the depolymerization mode of the blood sample to be tested based on the viscosity information. The depolymerization mode includes a first depolymerization mode and a second depolymerization mode, and the depolymerization intensity of the first depolymerization mode is different from that of the second depolymerization mode. (3) The controller controls the liquid driving module to drive the blood sample to be tested to perform depolymerization processing according to the determined depolymerization mode, and after the depolymerization processing, controls the erythrocyte sedimentation rate (ESR) detection component to obtain the aggregation detection data of the blood sample to be tested, and obtains the ESR detection result based on the aggregation detection data.

[0044] In a specific example of blood sample analysis methods, such as Figure 3 As shown, it includes the following steps: (100) After the identification module identifies that the test item of the sample to be tested includes erythrocyte sedimentation rate (ESR) test, the sampling module collects the blood sample to be tested from the sample to be tested into the aspiration tube and transports at least part of the blood sample to be tested into the detection tube. During the blood sample transport stage, the optical detection component in the ESR detection module monitors the light signal in real time. Through the timing of the signal change point, known tube parameters (such as the tube length L and tube cross-sectional area A where pressure drop occurs) and known driving parameters (such as the driving pressure difference ΔP of the tube where pressure drop occurs), the flow rate v of the blood sample to be tested is calculated. Then, the volumetric flow rate Q and apparent viscosity η of the blood sample to be tested are calculated according to Equation (I) and Equation (II). Thus, the function 1 of the blood sample analyzer is realized: accurate positioning and viscosity estimation of the blood sample to be tested.

[0045] (200) During the stable phase of the blood sample to be tested, the erythrocyte sedimentation rate (ESR) detection module obtains the initial transmittance of the blood sample to be tested, inputs it into the pre-calibration model, and estimates the hematocrit (HCT) of the blood sample to be tested, thereby realizing the second function of the blood sample analyzer: calculation of the hematocrit (HCT) of the blood sample to be tested.

[0046] (300) The controller, based on the viscosity and HCT of the blood sample to be tested calculated in steps (100) and (200), determines the depolymerization mode of the blood sample to be tested, and determines whether the blood sample to be tested is high viscosity and / or high HCT or low viscosity and / or low HCT. Generally, a blood sample to be tested is considered high viscosity when its viscosity is higher than that of a normal blood sample, and high HCT when its HCT is higher than that of a normal blood sample. A blood sample to be tested is considered low viscosity when its viscosity is lower than or the same as that of a normal blood sample, and low HCT when its HCT is lower than or the same as that of a normal blood sample. For blood samples to be tested with high viscosity and / or high HCT, the depolymerization mode of the detection module is strong depolymerization mode; for blood samples to be tested with low viscosity and / or low HCT, the depolymerization mode of the detection module is weak depolymerization mode. This achieves the third function of the blood sample analyzer: adaptive control of the depolymerization mode based on the viscosity of the blood sample to be tested.

[0047] (400) During the blood sample delivery stage, when the optical detection component in the detection module monitors the light signal in real time, its optical data (e.g., light intensity) will also change when the sample being detected changes (e.g., light intensity). Figure 4 (As shown); the detection module is also configured to determine, based on the depolymerization optical data of the blood sample to be tested, whether there is a sample abnormality in the blood sample to be tested that would cause abnormal erythrocyte sedimentation rate (ESR) test results, and when it is determined that there is a sample abnormality (such as... Figure 5 When an abnormality is detected (as shown), an alarm is output; an abnormality is indicated by the presence of air bubbles and / or small clots in the blood sample being tested. This achieves the fourth function of the blood sample analyzer: abnormality (air bubbles and / or clots) alarm.

[0048] (500) The detection module also includes a sedimentation monitoring stage, in which the dynamic curve of the blood sample to be tested is monitored to calculate the erythrocyte sedimentation rate, thereby realizing the fifth function of the blood sample analyzer: calculating the erythrocyte sedimentation rate of the blood sample to be tested.

[0049] The above description of the embodiments is provided to enable those skilled in the art to understand and apply the present invention. It will be apparent to those skilled in the art that various modifications can be easily made to these embodiments, and the general principles described herein can be applied to other embodiments without inventive effort. Therefore, the present invention is not limited to the embodiments described herein, and any improvements and modifications made by those skilled in the art based on the disclosure of the present invention without departing from the scope of the invention should be within the protection scope of the present invention.

Claims

1. A sample analyzer, characterized in that, include: The identification module is used to identify the detection items of the sample to be tested. The sampling module includes a sample needle, a suction tubing connected to the sample needle, and a sample needle driving device for driving the sample needle to move; one end of the sample needle is used to insert into the sample container to draw the blood sample to be tested from the sample to be tested, and the other end is connected to the suction tubing; A liquid driving module, which is connected to the sample suction line, is used to provide driving force for the flow of fluid within the sample needle and the sample suction line; The erythrocyte sedimentation rate (ESR) detection module includes an ESR detection component; an ESR detection section is configured on the sampling tube or the detection tube connected to the sampling tube, and the ESR detection component is used to detect the blood sample to be tested located on or flowing through the ESR detection section; The controller is configured to control the identification module, sampling module, liquid driving module, and erythrocyte sedimentation rate (ESR) detection module. When the identification module identifies that the test item for the sample to be tested includes erythrocyte sedimentation rate (ESR) testing, the controller controls the sampling module to aspirate the blood sample to be tested and controls the liquid driving module to drive the blood sample to be tested into the aspiration tubing and / or the detection tubing. The controller is further configured to, during the process of the blood sample to be tested moving from the sample needle to the erythrocyte sedimentation rate (ESR) detection unit, control the ESR detection component to detect the arrival time of the blood sample to be tested to the ESR detection unit, obtain the viscosity information of the blood sample to be tested based on the movement time information including the arrival time, and determine the depolymerization mode of the blood sample to be tested based on the viscosity information. The depolymerization mode includes a first depolymerization mode and a second depolymerization mode, and the depolymerization intensity of the first depolymerization mode is different from that of the second depolymerization mode. The controller is also configured to control the liquid driving module to drive the blood sample to be tested to undergo depolymerization processing according to the determined depolymerization mode, and after the depolymerization processing, control the erythrocyte sedimentation rate (ESR) detection component to acquire the aggregation detection data of the blood sample to be tested, and obtain the ESR detection result based on the aggregation detection data.

2. The sample analyzer according to claim 1, characterized in that, The first de-cluster mode is a conventional de-cluster mode, and the second de-cluster mode is an unconventional de-cluster mode; The unconventional de-aggregation mode includes at least one of a strong de-aggregation mode and a weak de-aggregation mode; The strong depolymerization mode has a greater depolymerization intensity than the conventional depolymerization mode, and the weak depolymerization mode has a lesser depolymerization intensity than the conventional depolymerization mode.

3. The sample analyzer according to claim 2, characterized in that, The unconventional de-aggregation mode includes the weak de-aggregation mode and the strong de-aggregation mode; The controller is configured to determine the depolymerization mode of the blood sample to be tested based on the viscosity information; When the viscosity information is within the first viscosity range, it is determined that the blood sample to be tested corresponds to the weak depolymerization mode; When the viscosity information is within the second viscosity range, it is determined that the blood sample to be tested corresponds to the conventional depolymerization mode; When the viscosity information is within the third viscosity range, it is determined that the blood sample to be tested corresponds to the strong depolymerization mode; Wherein, the viscosity corresponding to the third viscosity range is greater than the viscosity corresponding to the second viscosity range, and the viscosity corresponding to the second viscosity range is greater than the viscosity corresponding to the first viscosity range.

4. The sample analyzer according to claim 3, characterized in that, The controller stores a correspondence between viscosity ranges and depolymerization modes, and the controller is configured to determine a depolymerization mode that matches the viscosity information based on the correspondence.

5. The sample analyzer according to claim 2, characterized in that, The controller is configured to determine a depolymerization mode based on the viscosity information of the blood sample to be tested, and to control the liquid driving module to drive the blood sample to be tested to flow and / or reciprocate according to the determined depolymerization mode, so as to perform a depolymerization process of corresponding intensity on the blood sample to be tested. The deagglomeration process is used to reduce the degree of cell aggregation in the blood sample to be tested.

6. The sample analyzer according to claim 5, characterized in that, The liquid driving module is used to drive the blood sample to be tested to flow and / or reciprocate in the sample flow path formed by the sample needle, the aspiration tubing and / or the detection tubing, so as to perform the depolymerization process on the blood sample to be tested.

7. The sample analyzer according to claim 6, characterized in that, The unconventional de-aggregation mode includes the weak de-aggregation mode and the strong de-aggregation mode; The liquid driving module drives the blood sample to be tested to flow and / or reciprocate according to the weak depolymerization mode, the normal depolymerization mode and the strong depolymerization mode, respectively; The weak depolymerization parameter, the conventional depolymerization parameter, and the strong depolymerization parameter include at least one of the following: driving speed, depolymerization time, depolymerization distance, number of reciprocating flows, and single driving volume; for the same depolymerization parameter, the parameter value of the strong depolymerization parameter is greater than the parameter value of the conventional depolymerization parameter, and the parameter value of the conventional depolymerization parameter is greater than the parameter value of the weak depolymerization parameter.

8. The sample analyzer according to claim 1, characterized in that, The controller is configured to control the liquid driving module to drive the blood sample to be tested from the sample needle to the erythrocyte sedimentation rate detection unit according to preset driving conditions, and to determine the time when the liquid driving module starts to drive the blood sample to be tested according to the preset driving conditions as the start time; The travel time information includes the time difference between the start time and the arrival time.

9. The sample analyzer according to claim 8, characterized in that, Under the preset driving conditions, the controller obtains the viscosity information of the blood sample to be tested based on the time difference, wherein the larger the time difference, the greater the viscosity of the blood sample to be tested as represented by the viscosity information.

10. The sample analyzer according to claim 1, characterized in that, The erythrocyte sedimentation rate (ESR) detection component includes a light-emitting element and a light-receiving element, which are located on opposite sides of the ESR detection unit. The controller is configured to determine the arrival time of the blood sample to be tested to the erythrocyte sedimentation rate (ESR) detection unit based on the time when the change in the light signal received by the light-receiving element meets a preset change condition.

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