A deodorant based on colloidal silver ions and its preparation method and application

Abstract

This invention belongs to the field of odor removal technology, specifically relating to an odor removal agent based on colloidal silver ions, its preparation method, and its application. The colloidal silver ion-based odor removal agent, by mass percentage, comprises 0.1-0.5% colloidal silver, 1-3% persimmon fruit extract, 1-2% 1-caffeoylquinic acid modified hydroxypropyl-β-cyclodextrin, 2-5% surfactant, 0.1-0.5% long-chain amino acids, 0.5-2% preservative, 0-0.5% fragrance, and deionized water to make up the balance to 100%. The odor removal agent provided by this invention can effectively remove odors from feces, urine, sweat, etc., while exhibiting excellent antibacterial activity against Escherichia coli, Staphylococcus aureus, and Klebsiella pneumoniae, and also possesses excellent stability.

Description

Technical Field

[0001] This invention belongs to the field of odor removal technology, specifically relating to an odor removal agent based on colloidal silver ions, its preparation method, and its application. Background Technology

[0002] In daily life, people are often troubled by various odors, such as car odors, shoe odors, toilet odors, pet odors, and the body odor of bedridden patients. Currently, most odor removal products on the market mask odors with strong scents, but cannot fundamentally solve the problem of odor dispersion.

[0003] Colloidal silver is a colloidal solution formed by suspending nano-sized particles (usually 1-100 nanometers) of metallic silver in pure water. The silver ions released by it are positively charged and can penetrate bacterial cell membranes, causing bacterial proteins to coagulate and enzymes to become inactive, thereby killing or inhibiting bacteria and fungi that cause odors.

[0004] However, colloidal silver has poor stability and is easily affected by light and heat. Moreover, it will age and degrade after being stored for a long time, resulting in a reduction in its antibacterial effect. Therefore, there are few reports on the application of colloidal silver in deodorizing agents.

[0005] A search revealed that Chinese Patent CN119351171A, in the prior art related to the stability of colloidal silver, discloses an antibacterial laundry cleaning composition containing colloidal silver and its preparation method. By mass percentage, the raw materials for its preparation include at least: 11-25% sulfate ester salt, 2-6% alkylbenzene sulfonic acid anionic surfactant, 2-6% amphoteric surfactant, 0.5-1.0% colloidal silver, 0.5-5.0% thickener, 0.02-0.5% magnolol, 0-0.5% chelating agent, and antibacterial agent. The composition includes 0-1.0% preservative, 0-2.0% flavoring, 0.3-0.8% alkalinity regulator, 0.01-0.2% acidity regulator, 0-2.0% sodium chloride, and deionized water to make up the balance. This technical solution controls the mass ratio of the alkylbenzene sulfonic acid anionic surfactant, sulfate ester salt, and amphoteric surfactant to (2-6):(11-18):(2-6), and the thickener and magnolol in the system ensure the stability of the cleaning composition containing colloidal silver. However, the surfactant in this solution is not suitable for preparing deodorizing agents.

[0006] Chinese patent CN110881481B discloses an antibacterial composition containing cannabis leaf extract, comprising cannabis leaf extract and an inorganic antibacterial agent. This technical solution combines cannabis leaf extract with colloidal silver, which not only ensures the effectiveness of colloidal silver but also enhances its antibacterial properties. Furthermore, it can effectively stabilize colloidal silver, preventing it from discoloring or deteriorating. However, the use of cannabis leaf extract is subject to strict legal and regulatory restrictions, resulting in poor application prospects. Summary of the Invention

[0007] The purpose of this invention is to overcome the shortcomings and deficiencies of the prior art and provide a deodorizing agent based on colloidal silver ions, its preparation method, and its application.

[0008] To achieve the above objectives, the present invention provides the following technical solution: A deodorizing agent based on colloidal silver ions, comprising, by weight percentage, 0.1-0.5% colloidal silver, 1-3% persimmon (DIOSPYROSKAKI) fruit extract, 1-2% 1-caffeoylquinic acid modified hydroxypropyl-β-cyclodextrin, 2-5% surfactant, 0.1-0.5% long-chain amino acids, 0.5-2% preservative, 0-0.5% fragrance, and deionized water to make up the balance to 100%.

[0009] As a preferred technical solution, the preparation method of 1-caffeoylquinic acid modified hydroxypropyl-β-cyclodextrin is as follows: 1-caffeoylquinic acid and ethanol are mixed, N,N'-dicyclohexylcarbodiimide and 4-dimethylaminopyridine are added, the mixture is stirred and activated at room temperature, hydroxypropyl-β-cyclodextrin is added, the mixture is stirred and reacted at room temperature, and after the reaction is completed, the mixture is distilled under reduced pressure, washed with deionized water, and dried to obtain the final product.

[0010] This invention primarily utilizes the combined effects of colloidal silver, persimmon extract, and 1-caffeoylquinic acid-modified hydroxypropyl-β-cyclodextrin to effectively remove odors from feces, urine, and sweat.

[0011] The cage-like ring structure of cyclodextrin can encapsulate odors and is commonly used as a physical deodorizer in the field. However, the inventors found that its effectiveness in removing odors from feces, urine, and sweat is poor when used alone. At the same time, the inventors realized that for patients who are bedridden for extended periods, their respiratory function and lung capacity are reduced, and they are unable to turn over independently, leading to the accumulation of respiratory secretions and increased susceptibility to bacterial infections. Furthermore, the antibacterial properties of the deodorizer obtained in this invention, which uses only colloidal silver, are also poor.

[0012] Based on the above two technical problems, the present invention creatively modifies hydroxypropyl-β-cyclodextrin with 1-caffeoylquinic acid. The polyhydroxy structure of 1-caffeoylquinic acid can work together with hydroxypropyl-β-cyclodextrin to not only effectively improve the deodorizing effect of the deodorizing agent, but also effectively improve the antibacterial properties of the deodorizing agent.

[0013] In addition, the inventors were pleasantly surprised to find that modifying hydroxypropyl-β-cyclodextrin with 1-caffeoylquinic acid effectively improved the stability of the deodorizing agent. This may be due to the fact that the polyhydroxy structure of 1-caffeoylquinic acid can slow down the oxidative degradation of nano-silver.

[0014] As a preferred technical solution, the average degree of substitution of the hydroxypropyl-β-cyclodextrin is 3.5-5.

[0015] As a preferred technical solution, the mass ratio of hydroxypropyl-β-cyclodextrin, ethanol, N,N'-dicyclohexylcarbodiimide, 4-dimethylaminopyridine and 1-caffeoylquinic acid is 10:200-300:1.5-3:1-2:2-4.

[0016] As a preferred technical solution, the room temperature stirring activation time is 1-3 hours.

[0017] As a preferred technical solution, the room temperature stirring reaction time is 12-24 hours.

[0018] As a preferred technical solution, the surfactant is a mixture of propylene glycol ricinoleate, PEG-40 hydrogenated castor oil, and polyoxyethylene phytosterol in a mass ratio of 4-7:2-4:1-2.

[0019] As a preferred technical solution, the polyoxyethylene phytosterol is selected from at least one of PEG-5 phytosterol, PEG-10 phytosterol, PEG-20 phytosterol and PEG-30 phytosterol.

[0020] As a preferred technical solution, the long-chain amino acid is selected from at least one of 9-aminononanoic acid, 10-aminodecanoic acid and 12-aminododecanoic acid.

[0021] The stability of colloidal silver is an important indicator for ensuring the deodorizing and antibacterial effects of deodorizing agents. To address the issue that colloidal silver is easily affected by light and heat, this invention optimizes the composition of the surfactant and introduces a specific long-chain amino acid. This long-chain amino acid differs from arginine and glycine commonly used in the field. Experimental verification shows that the long-chain amino acid, in conjunction with the surfactant, can effectively improve the stability of the deodorizing agent compared to arginine and glycine. This may be due to the fact that the long-chain amino acid has a larger molecular volume, which can effectively adsorb onto the surface of colloidal silver, thereby slowing down the oxidative degradation of nano-silver.

[0022] In this invention, there are no special requirements for the specific selection of the preservative. Any conventional type in the art can be selected, including but not limited to at least one of phenoxyethanol, hydantoin, p-hydroxyacetophenone, methyl p-hydroxybenzoate, propyl p-hydroxybenzoate, butyl p-hydroxybenzoate, benzoic acid, sodium benzoate, butyl hydroxytoluene, butyl hydroxyanisole, acetylated propionic acid, and anisic acid.

[0023] There are no special requirements for the specific selection of the flavoring in this invention. Any conventional type in the art can be selected, including but not limited to at least one of orange flavoring, apple flavoring, mango flavoring, and strawberry flavoring.

[0024] The second aspect of the present invention provides a method for preparing a deodorizing agent based on colloidal silver ions, comprising the following steps: mixing surfactant, long-chain amino acid and water evenly, adding colloidal silver, persimmon fruit extract, 1-caffeoylquinic acid modified hydroxypropyl-β-cyclodextrin, preservative and flavoring and mixing evenly to obtain the deodorizing agent.

[0025] The third aspect of this invention provides the application of a colloidal silver ion-based deodorizer in removing body odor from bedridden patients, car interior odors, shoe odors, toilet odors, or pet odors.

[0026] Compared with the prior art, the advantages and beneficial effects of the present invention are as follows: 1. This invention creatively uses 1-caffeoylquinic acid to modify hydroxypropyl-β-cyclodextrin. The polyhydroxy structure of 1-caffeoylquinic acid can work together with hydroxypropyl-β-cyclodextrin to not only effectively improve the deodorizing effect of the deodorizing agent on odors such as feces, urine and sweat, but also effectively improve the antibacterial properties and stability of the deodorizing agent.

[0027] 2. This invention can effectively improve the stability of the deodorizing agent by optimizing the composition of the surfactant and introducing specific long-chain amino acids.

[0028] 3. The deodorizing agent based on colloidal silver ions provided by this invention has an antibacterial rate of >99.9% against Escherichia coli, Staphylococcus aureus, and Klebsiella pneumoniae subsp. pneumoniae. After being placed at high temperature (60℃) for 15 days, the antibacterial rate against Escherichia coli, Staphylococcus aureus, and Klebsiella pneumoniae subsp. pneumoniae is >98%. After being placed under strong light (4500+500Lx) for 15 days, the antibacterial rate against Escherichia coli, Staphylococcus aureus, and Klebsiella pneumoniae subsp. pneumoniae is >97%. Attached Figure Description

[0029] Figure 1 The results of the odor removal agent of Example 1 being sent to an external testing agency for odor removal effect testing.

[0030] Figure 2 The results of the antibacterial effect test of the deodorizing agent of Example 1 sent to an external testing agency are shown. Detailed Implementation

[0031] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0032] Unless otherwise specified in the examples and comparative examples, the conditions were performed under standard conditions or conditions recommended by the manufacturer. All reagents and instruments used were commercially available products unless otherwise specified.

[0033] The colloidal silver was sourced from Guangzhou He'an Chemical Co., Ltd. The persimmon fruit extract is sourced from Guangzhou Zhongran Biotechnology Co., Ltd. 1-Caffeoylquinic acid is derived from Chengdu Purifa Technology Development Co., Ltd.; Hydroxypropyl-β-cyclodextrin was obtained from Beijing Solarbio Technology Co., Ltd., with an average degree of substitution of 4.9. Propylene glycol ricinoleate is sourced from Nantong Zhonghe Chemical New Materials Co., Ltd. PEG-40 hydrogenated castor oil is sourced from Zhengzhou Oubao Biotechnology Co., Ltd. PEG-5 phytosterols are sourced from Nikko Chemical Trading (Shanghai) Co., Ltd.; 9-Aminononanoic acid is derived from Shanghai Yuanye Biotechnology Co., Ltd.

[0034] Example 1

[0035] This embodiment provides an odor remover based on colloidal silver ions. By mass percentage, the raw materials include 0.1% colloidal silver, 3% persimmon fruit extract, 1.5% 1-caffeoylquinic acid modified hydroxypropyl-β-cyclodextrin, 3% surfactant, 0.3% long-chain amino acids, 0.5% preservative, 0.1% fragrance, and deionized water to make up the balance to 100%.

[0036] The preparation method of the 1-caffeoylquinic acid modified hydroxypropyl-β-cyclodextrin is as follows: Mix 1-caffeoylquinic acid and ethanol, add N,N'-dicyclohexylcarbodiimide and 4-dimethylaminopyridine, stir and activate at room temperature for 2 h, add hydroxypropyl-β-cyclodextrin, stir and react at room temperature for 2 h, after the reaction is completed, distill under reduced pressure, wash with deionized water, and dry to obtain the product.

[0037] The mass ratio of hydroxypropyl-β-cyclodextrin, ethanol, N,N'-dicyclohexylcarbodiimide, 4-dimethylaminopyridine, and 1-caffeoylquinic acid is 10:250:2.4:1.5:3.

[0038] The surfactant is a mixture of propylene glycol castor oil, PEG-40 hydrogenated castor oil, and polyoxyethylene phytosterol in a mass ratio of 6:3:1.

[0039] The polyoxyethylene phytosterol is PEG-5 phytosterol.

[0040] The long-chain amino acid is 9-aminononanoic acid.

[0041] The preservative is phenoxyethanol.

[0042] The flavoring is orange flavoring.

[0043] The above-mentioned deodorizing agent based on colloidal silver ions includes the following steps: mixing surfactant, long-chain amino acid and water evenly, adding colloidal silver, persimmon fruit extract, 1-caffeoylquinic acid modified hydroxypropyl-β-cyclodextrin, preservative and fragrance and mixing evenly to obtain the deodorizing agent.

[0044] Example 2

[0045] This embodiment provides an odor remover based on colloidal silver ions. The only difference from Example 1 is that, by mass percentage, the raw materials include 0.3% colloidal silver, 2% persimmon fruit extract, 2% 1-caffeoylquinic acid modified hydroxypropyl-β-cyclodextrin, 2% surfactant, 0.2% long-chain amino acids, 0.8% preservative, 0.2% fragrance, and deionized water to make up the balance to 100%.

[0046] Example 3

[0047] This embodiment provides an odor remover based on colloidal silver ions. The only difference from Example 1 is that, by mass percentage, the raw materials include 0.5% colloidal silver, 1% persimmon fruit extract, 1% 1-caffeoylquinic acid modified hydroxypropyl-β-cyclodextrin, 4% surfactant, 0.5% long-chain amino acids, 0.6% preservative, 0.3% fragrance, and deionized water to make up the balance to 100%.

[0048] Comparative Example 1 This comparative example provides a deodorizing agent based on colloidal silver ions. The only difference from Example 1 is that 1-caffeoylquinic acid modified hydroxypropyl-β-cyclodextrin is replaced with an equal mass of hydroxypropyl-β-cyclodextrin; all other aspects are the same.

[0049] Comparative Example 2 This comparative example provides a deodorizing agent based on colloidal silver ions. The only difference from Example 1 is that the 1-caffeoylquinic acid modified hydroxypropyl-β-cyclodextrin is replaced with hydroxypropyl-β-cyclodextrin and 1-caffeoylquinic acid in a mass ratio of 10:3; all other aspects are the same.

[0050] Comparative Example 3 This comparative example provides an odor remover based on colloidal silver ions. The only difference from Example 1 is that the surfactant is a mixture of PEG-40 hydrogenated castor oil and dehydrated sorbitol monolaurate in a mass ratio of 1:1; all other aspects are the same.

[0051] Comparative Example 4 This comparative example provides an odor remover based on colloidal silver ions. The only difference from Example 1 is that the surfactant is a mixture of propylene glycol ricinoleate, PEG-40 hydrogenated castor oil, and nonylphenol polyether-14 in a mass ratio of 6:3:1; all other aspects are the same.

[0052] Comparative Example 5 This comparative example provides an odor remover based on colloidal silver ions. The only difference from Example 1 is that the surfactant is a mixture of polysorbate-20, PEG-40 hydrogenated castor oil, and polyoxyethylene phytosterol in a mass ratio of 6:3:1; all other aspects are the same.

[0053] Comparative Example 6 This comparative example provides an odor remover based on colloidal silver ions, which differs from Example 1 only in that the long-chain amino acid is replaced with arginine; all other aspects are the same.

[0054] Comparative Example 7 This comparative example provides an odor remover based on colloidal silver ions, which differs from Example 1 only in that the long-chain amino acid is replaced with glycine; all other aspects are the same.

[0055] Performance testing: The deodorizing agents prepared in the above examples and comparative examples were subjected to the following performance tests.

[0056] I. Odor Removal Effect: 1. Laboratory level: The deodorization effects of 3-methylindole (characterizing fecal odor), n-butylamine (characterizing fishy and urine odor), and isovaleric acid (characterizing sweat odor) were tested according to Appendix A of QB / T 5994-2024. The deodorization effect scoring table is shown in Table 1 below, and the results are shown in Table 2.

[0057] 2. Professional Level: The odor-removing agent of Example 1 was sent to an external testing agency for odor removal effect testing. The test results are as follows: Figure 1 As shown, by Figure 1 It can be seen that the deodorizing effect of the deodorizing agent in Example 1 is consistent with the laboratory-level test results.

[0058] Table 1

[0059] Table 2

[0060] From Table 2 and Figure 1 It can be seen that the deodorizing agents in Examples 1-3 have excellent deodorizing effects on fecal odor, urine odor, and sweat odor.

[0061] As can be seen from Comparative Examples 1-2, compared with the technical solutions of not using 1-caffeoylquinic acid to modify hydroxypropyl-β-cyclodextrin and directly mixing 1-caffeoylquinic acid and hydroxypropyl-β-cyclodextrin, the 1-caffeoylquinic acid modified hydroxypropyl-β-cyclodextrin prepared in this invention can significantly improve the deodorizing effect of the deodorizing agent on fecal odor, urine odor and sweat odor.

[0062] II. Antibacterial effect: 1. Laboratory level: The antibacterial activity against Escherichia coli, Staphylococcus aureus and Klebsiella pneumoniae subsp. pneumoniae was tested according to QB / T 2738-2023 7.2. The effective concentration was: stock solution, and the effective time was 30 min. The results are shown in Table 3.

[0063] 2. Professional Level: The deodorizing agent from Example 1 was sent to an external testing agency for antibacterial effect testing. The test results are as follows: Figure 2 As shown, by Figure 2 It can be seen that the deodorizing effect of the deodorizing agent in Example 1 is consistent with the laboratory-level test results.

[0064] Table 3

[0065] From Table 2 and Figure 2 It can be seen that the deodorizing agents in Examples 1-3 have excellent antibacterial effects against Escherichia coli, Staphylococcus aureus, and Klebsiella pneumoniae subsp. pneumoniae.

[0066] As can be seen from Comparative Examples 1-2, compared with the technical solutions of not using 1-caffeoylquinic acid to modify hydroxypropyl-β-cyclodextrin and directly mixing 1-caffeoylquinic acid and hydroxypropyl-β-cyclodextrin, the 1-caffeoylquinic acid modified hydroxypropyl-β-cyclodextrin prepared in this invention can significantly improve the antibacterial effect of the deodorizing agent on Escherichia coli, Staphylococcus aureus and Klebsiella pneumoniae subsp. pneumoniae.

[0067] III. Stability: The product was placed under two conditions: high temperature (60℃) and strong light (4500+500Lx) to conduct the high temperature and strong light influence test. After 15 days, its deodorizing effect on 3-methylindole and its antibacterial performance against Klebsiella pneumoniae subsp. pneumoniae were tested. The results are shown in Table 4.

[0068] Table 4

[0069] As can be seen from Table 4, the deodorizing agents of Examples 1-3 have excellent stability. Even after being placed under high temperature and strong light for 15 days, they still have excellent deodorizing effect on fecal odor and excellent antibacterial properties against Klebsiella pneumoniae subsp. pneumoniae.

[0070] As can be seen from Comparative Examples 1-2, compared with the technical solutions of not using 1-caffeoylquinic acid to modify hydroxypropyl-β-cyclodextrin and directly mixing 1-caffeoylquinic acid and hydroxypropyl-β-cyclodextrin, the 1-caffeoylquinic acid modified hydroxypropyl-β-cyclodextrin prepared in this invention can significantly improve the stability of the deodorizing agent. As can be seen from Comparative Examples 3-7, using propylene glycol castor oil, PEG-40 hydrogenated castor oil, and polyoxyethylene phytosterol as surfactants, combined with long-chain amino acids, can significantly improve the stability of the deodorizing agent.

[0071] The above description represents the preferred embodiments of the present invention. It should be noted that those skilled in the art can make various improvements and modifications without departing from the principles of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A deodorizing agent based on colloidal silver ions, characterized in that, By weight percentage, the raw materials include 0.1-0.5% colloidal silver, 1-3% persimmon fruit extract, 1-2% 1-caffeoylquinic acid modified hydroxypropyl-β-cyclodextrin, 2-5% surfactant, 0.1-0.5% long-chain amino acids, 0.5-2% preservative, 0-0.5% flavoring, and deionized water to make up the balance to 100%.

2. The deodorizing agent based on colloidal silver ions according to claim 1, characterized in that, The preparation method of 1-caffeoylquinic acid modified hydroxypropyl-β-cyclodextrin is as follows: 1-caffeoylquinic acid and ethanol are mixed, N,N'-dicyclohexylcarbodiimide and 4-dimethylaminopyridine are added, the mixture is stirred and activated at room temperature, hydroxypropyl-β-cyclodextrin is added, the mixture is stirred and reacted at room temperature, and after the reaction is completed, the mixture is distilled under reduced pressure, washed with deionized water, and dried to obtain the final product.

3. The deodorizing agent based on colloidal silver ions according to claim 2, characterized in that, The average degree of substitution of the hydroxypropyl-β-cyclodextrin is 3.5-5.

4. The deodorizing agent based on colloidal silver ions according to claim 3, characterized in that, The mass ratio of hydroxypropyl-β-cyclodextrin, ethanol, N,N'-dicyclohexylcarbodiimide, 4-dimethylaminopyridine, and 1-caffeoylquinic acid is 10:200-300:1.5-3:1-2:2-4.

5. The deodorizing agent based on colloidal silver ions according to claim 4, characterized in that, The room temperature stirring activation time is 1-3 hours; the room temperature stirring reaction time is 12-24 hours.

6. The deodorizing agent based on colloidal silver ions according to any one of claims 1-5, characterized in that, The surfactant is a mixture of propylene glycol castor oil, PEG-40 hydrogenated castor oil, and polyoxyethylene phytosterol in a mass ratio of 4-7:2-4:1-2.

7. The deodorizing agent based on colloidal silver ions according to claim 6, characterized in that, The polyoxyethylene phytosterol is selected from at least one of PEG-5 phytosterol, PEG-10 phytosterol, PEG-20 phytosterol and PEG-30 phytosterol.

8. The deodorizing agent based on colloidal silver ions according to claim 7, characterized in that, The long-chain amino acid is selected from at least one of 9-aminononanoic acid, 10-aminodecanoic acid, and 12-aminododecanoic acid.

9. The method for preparing the deodorizing agent based on colloidal silver ions according to any one of claims 1-8, characterized in that, The process includes the following steps: mixing surfactants, long-chain amino acids and water evenly, then adding colloidal silver, persimmon fruit extract, 1-caffeoylquinic acid modified hydroxypropyl-β-cyclodextrin, preservatives and flavorings and mixing evenly to obtain the final product.

10. The use of the deodorizing agent based on colloidal silver ions according to any one of claims 1-8 in removing body odor from bedridden patients, car interior odor, shoe odor, toilet odor, or pet odor.

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