A thiazole zinc-containing synergistic fungicidal composition and application thereof

Abstract

This invention discloses a thiazolium zinc-containing synergistic fungicide composition and its application, relating to the field of pesticide compounding technology. By compounding compound I with thiazolium zinc, this invention obtains a synergistic fungicide composition containing thiazolium zinc that exhibits enhanced control efficacy, slows the development of resistance, broadens the fungicidal spectrum for stronger action against bacterial diseases, reduces application dosage, decreases the number of applications, and lowers usage costs.

Description

Technical Field

[0001] This invention relates to the field of pesticide compound technology, and in particular to a thiamethoxam zinc-containing synergistic fungicide composition and its application. Background Technology

[0002] In recent years, the incidence of various bacterial diseases in crops has shown a trend of increasing severity year by year, with the affected area growing annually, causing significant harm to agricultural production. In actual agricultural production, the long-term, continuous use of the same pesticide quickly leads to the development of resistance in pathogens, resulting in reduced efficacy and increased pesticide usage. Combining fungicides with completely different mechanisms of action is an effective way to delay the development of resistance in pathogens, broaden the fungicidal spectrum, extend the pesticide's lifespan, and reduce pesticide usage.

[0003] Compound I is a highly effective bactericide that kills bacteria by inhibiting bacterial DNA gyrase activity, thus preventing bacterial replication. Its bactericidal effect has been well demonstrated in CN119912446B. Thiazole zinc is a bactericide currently used in agricultural production. Its mechanism of action involves zinc ions disrupting the cell membrane structure of pathogenic bacteria, leading to leakage of cell contents. Thiazole zinc can also interfere with bacterial metabolic processes, exhibiting a completely different mechanism of action from Compound I.

[0004] In actual agricultural production, the long-term, continuous use of the same pesticide will quickly lead to the development of resistance in pathogens, resulting in reduced efficacy, increased pesticide usage, and exacerbated pesticide residues in agricultural products and damage to the ecological environment. Combining fungicides with completely different mechanisms of action is an effective way to delay the development of resistance in pathogens, broaden the spectrum of fungicides, extend their lifespan, and reduce pesticide usage. Summary of the Invention

[0005] To address the issue of drug resistance arising from the use of a single agent, this invention provides a thiazole zinc-containing synergistic fungicide composition and its application. Through a compounding method, the thiazole zinc-containing synergistic fungicide composition exhibits good disease resistance against bacterial angular leaf spot in cucumber and bacterial stripe disease in rice.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: A synergistic bactericidal composition containing zinc thiazole includes an active ingredient comprising compound I and zinc thiazole, wherein compound I has the following structure:

[0007] Preferably, the mass ratio of compound I to zinc thiazole is 1:9 to 9:1.

[0008] Preferably, the mass ratio of compound I to zinc thiazole is 1:4 to 4:1.

[0009] Preferably, it further includes at least one of the following: emulsifier, dispersant, wetting agent, thickener, defoamer, stabilizer, binder, disintegrant, antifreeze, anticaking agent, suspending agent, film-forming agent, preservative, colorant, polymeric capsule wall material, pH adjuster, or filler.

[0010] Preferably, the emulsifier comprises one or more of the following: sodium lignosulfonate, agricultural emulsion, phenylphenol polyoxyethylene ether phosphate, tristyrylphenol polyoxyethylene ether phosphate triethanolamine salt, benzyl dimethylphenol polyoxyethylene ether, sorbitan fatty acid ester polyoxyethylene ether, sorbitan anhydride oleate (Span-80), fatty alcohol polyoxyethylene ether, sodium alkyl naphthalene sulfonate, sodium isooctanol succinate sulfonate, nonylphenol polyoxyethylene ether phosphate, and castor oil polyoxyethylene ether phosphate.

[0011] Preferably, the dispersant comprises one or more of the following: glycerol fatty acid polyoxyethylene ether, polyoxyethylene alkyl aryl ether, sodium lignosulfonate, naphthalene sulfonate formaldehyde condensate, fatty alcohol polyoxyethylene ether sulfate, naphthalene sulfonate formaldehyde condensate, sodium naphthalene sulfonate formaldehyde condensate, nonylphenol polyoxyethylene ether, polyoxyethylene lanolin alcohol, alkylphenol polyoxyethylene ether formaldehyde condensate, fatty alcohol polyoxyethylene ether, fatty alcohol polyoxyethylene ether phosphate, polyoxyethylene sorbitan fatty acid ester, and phosphate ester. The wetting agent includes one or more of the following: trisiloxane polyoxyethylene ether, sodium N-lauroyl glutamate, sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium methylnaphthalene sulfonate formaldehyde condensate, castor oil polyoxyethylene ether, triphenylethylphenol polyoxyethylene ether, sodium dodecylbenzene sulfonate, sodium alkylnaphthalene sulfonate, sodium isooctanol succinate sulfonate, polyoxyethylene alkyl aryl ether, fatty alcohol polyether glycerol fatty acid polyoxyethylene ether, and fatty alcohol polyoxyethylene ether. The binder includes one or more of xanthan gum, starch, urea-formaldehyde resin, gelatin, gum arabic, carboxymethyl cellulose, carboxyethyl cellulose, and polyvinyl alcohol; The disintegrant includes one or more of sodium bicarbonate, ammonium sulfate, sodium sulfate, calcium sulfate, and magnesium chloride; The thickener includes one or more of magnesium aluminum silicate, polyvinyl acetate, xanthan gum, gelatin, gum arabic, and polyvinyl alcohol; The defoamer includes one or more of silicone oil, n-octanol, silicone, butyl phosphate, and isobutyl phosphate; The antifreeze agent includes one or more of propylene glycol, ethylene glycol, and glycerol; The stabilizer includes one or more of triethanolamine, epichlorohydrin, butyl glycidyl ether, triphenyl phosphite, N-soybean oil-based trimethylenediamine, and dialkyl succinate acesulfonate. The filler includes solid filler and liquid filler, wherein the solid filler includes one or more of kaolin, attapulgite, diatomaceous earth, silica, bentonite, montmorillonite, calcium carbonate, and talc; and the liquid filler includes one or more of soybean oil, castor oil, and mineral oil.

[0012] Preferably, the thiazole zinc synergistic bactericidal composition is prepared as a liquid or solid formulation; The liquid formulation contains 1% to 80% by weight of the effective active ingredient; The solid dosage form contains 5% to 80% of the effective active ingredient by weight.

[0013] Preferably, the liquid formulation comprises at least one of a dispersible liquid, a suspension, an emulsion, a microemulsion, a suspension emulsion, a microcapsule suspension, a seed coating suspension, or an emulsifiable concentrate; The solid dosage form includes at least one of water-dispersible granules, pellets, or wettable powders.

[0014] The present invention also provides the application of a thiazole zinc-containing synergistic bactericidal composition in the prevention and control of bacterial diseases in agricultural production.

[0015] The present invention has the following technical effects: (1) The thiazole zinc-containing synergistic fungicide composition of the present invention has a synergistic effect, which can improve the control effect and slow down the development of resistance; at the same time, diseases in the field often occur in a mixed manner, and the thiazole zinc-containing synergistic fungicide composition of the present invention can broaden the fungicide spectrum and have a stronger effect on bacterial diseases; the thiazole zinc-containing synergistic fungicide composition of the present invention can reduce the amount of pesticide applied, reduce the number of times it is used, and reduce the cost of use.

[0016] (2) The bactericidal composition of the present invention can be provided in the form of a finished formulation or as a single agent. It is mixed directly before use, then diluted with water to achieve the desired concentration. It can be applied to plants or crops in any manner, such as spraying, root irrigation, or application. In specific applications, it can also be mixed with other agents such as insecticides, growth regulators, soil conditioners, herbicides, and nematicides. It is convenient to use and has a wide range of applications, making it widely applicable in crop cultivation. Detailed Implementation

[0017] To more clearly illustrate the technical solution and beneficial effects of the present invention, this patent provides a more detailed description in conjunction with specific implementation examples; it is worth noting that the specific implementation examples are only used to explain the present invention, but are not limited to the present invention.

[0018] Compound I and thiazolyl zinc are both commercially available. Example

[0019] wettable powder Compound I: 2%, thiazole zinc: 5%, sodium dodecylbenzene sulfonate: 2%, sodium lignosulfonate: 10%, talc: 3%, and attapulgite clay are added to make 100%. The above materials are coarsely pulverized in proportion and then mixed evenly in a mixer. After being pulverized by air jet milling, the finished product is obtained. Example

[0020] Water-dispersible granules Compound I: 10%, thiazolyl zinc: 15%, sodium alkylnaphthalene sulfonate: 4%, sodium lignosulfonate: 10%, sodium dodecyl sulfate: 3%, ammonium sulfate: 4%, and kaolin are added to make 100%. The active ingredients and various adjuvants are mixed evenly according to the formula ratio, and then the mixture is pulverized by air jet to obtain powder. Water of 20% of the total weight of the preparation is added, and the mixture is mixed, extruded and granulated. After drying and sieving, the finished product is obtained. Example

[0021] Suspension Compound I: 10%, thiazolyl zinc: 10%, sodium methylnaphthalene sulfonate: 5%, xanthan gum: 8%, propylene glycol: 5%, sodium naphthalene sulfonate formaldehyde condensate: 3%, and deionized water to make up to 100%. The active ingredients and various additives are mixed evenly according to the formula ratio, and then the mixture is subjected to high-speed shearing and sand milling to obtain the finished product. Example

[0022] Suspension Compound I: 20%, thiazolyl zinc: 5%, sodium methylnaphthalene sulfonate: 5%, xanthan gum: 8%, propylene glycol: 8%, sodium naphthalene sulfonate formaldehyde condensate: 3%, and deionized water to make up to 100%. The active ingredients and various additives are mixed evenly according to the formula ratio, and then the mixture is subjected to high-speed shearing and sand milling to obtain the finished product.

[0023] Example 5 emulsifiable concentrate Mix compound I (10%), thiazolium zinc (10%), tristyrene-phenylphenol polyoxyethylene ether phosphate triethanolamine salt (5%), fatty alcohol polyethylene ether (5%), propylene glycol (5%), and solvent oil to a final volume of 100%. Dissolve the above raw materials in the specified proportions to form a homogeneous oil phase, which is the finished product. Example

[0024] water emulsion Compound I: 10%, thiazolyl zinc: 5%, sodium methylnaphthalene sulfonate: 5%, ethanol: 35%, propylene carbonate: 15%, solvent oil: 13%, Span-80: 10%, ethylene glycol: 3%, silicone oil: 0.5%, polyvinyl alcohol: 0.5%, and deionized water to 100% are added to the mixing tank according to the formula requirements. The mixture is then mixed evenly using a high-speed shearing machine to prepare an emulsion. Example

[0025] water emulsion The following ingredients were added to a mixing tank according to the formulation requirements: Compound I: 5%, Thiazole Zinc: 5%, Sodium Methylnaphthalene Sulfonate: 5%, Ethanol: 35%, Propylene Carbonate: 20%, Solvent Oil: 13%, Span-80: 10%, Ethylene Glycol: 3%, Silicone Oil: 0.5%, Polyvinyl Alcohol: 0.5%, and deionized water to 100%. The mixture was then thoroughly mixed using a high-speed shearing machine to prepare an emulsion. Example

[0026] Granules The following ingredients are mixed: Compound I: 1%, Thiazole Zinc: 1%, Sodium Lignosulfonate: 5%, Sodium Dodecyl Sulfate: 4%, Polyvinyl Alcohol: 3%, Silica: 10%, and Diatomaceous Earth to make up to 100%. The mixture is then pulverized, moistened with water, and stirred thoroughly. The mixture is then granulated using a screw extruder, dried, and sieved to obtain the finished product.

[0027] Referring to the agricultural industry standard of the People's Republic of China, standard number: NY / T1156.16-2008, standard name: Indoor bioassay test standard for pesticides - fungicides part 16: requirements for turbidity method for test of bacterial growth inhibition, the inhibitory activity of the pesticide on bacterial fruit spot disease of cucumber was tested. The test results are shown in the table below, showing that compound I and thiamethoxam zinc showed good synergistic activity.

[0028]

[0029] Example

[0030] Test method: The drug was applied according to the provisions of the National Standard of the People's Republic of China GB / T17980.110-2004. The drug was applied when the lesions first appeared, and the drug was applied again 7 days later. The drug was applied twice in total, and the number of times was repeated was 4.

[0031] Survey Methods: Following the survey methods specified in the National Standard of the People's Republic of China GB / T 17980.110-2004, the control effect was assessed 7 and 14 days after the second application. Three diagonal sampling points were taken from each plot, with five plants at each point. All leaves were surveyed, and the treatment was graded based on the percentage of diseased area per leaf relative to the total leaf area.

[0032] Grading method: Grade 0: No lesions; Grade 1: Lesions cover less than 5% of the total leaf area; Grade 3: Lesions cover 6%–10% of the total leaf area; Grade 5: Lesions cover 11%–20% of the total leaf area; Grade 7: Lesions cover 21%–50% of the total leaf area; Grade 9: Lesions cover more than 51% of the total leaf area.

[0033] The efficacy of compound I combined with thiazole zinc in a field study of bacterial angular leaf spot disease in cucumber was shown in Examples 3 and 4.

[0034]

[0035] The efficacy of compound I combined with thiamethoxam zinc in a field study of bacterial stripe disease in rice was shown in Example 7.

[0036] The above efficacy experiments show that the combination of compound I and thiamethoxam zinc can effectively control bacterial diseases in crops, and the two have a good synergistic effect.

[0037] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A synergistic bactericidal composition containing thiazole zinc, characterized in that, The active ingredients include compound I and zinc thiazole, wherein compound I has the following structure:

2. The thiazole-zinc synergistic bactericidal composition according to claim 1, characterized in that, The mass ratio of compound I to zinc thiazole is 1:9 to 9:

1.

3. The thiazole-zinc synergistic bactericidal composition according to claim 1, characterized in that, The mass ratio of compound I to thiazole zinc is 1:4 to 4:

1.

4. The thiazole-zinc synergistic bactericidal composition according to claim 1, characterized in that, It also includes at least one of the following: emulsifier, dispersant, wetting agent, thickener, defoamer, stabilizer, binder, disintegrant, antifreeze, anticaking agent, suspending agent, film-forming agent, preservative, colorant, polymeric capsule wall material, pH adjuster, or filler.

5. The thiazole zinc-containing synergistic bactericidal composition according to claim 4, characterized in that, The emulsifier includes one or more of the following: sodium lignosulfonate, agricultural emulsion, phenylphenol polyoxyethylene ether phosphate, tristyrylphenol polyoxyethylene ether phosphate triethanolamine salt, benzyl dimethylphenol polyoxyethylene ether, sorbitan fatty acid ester polyoxyethylene ether, sorbitan anhydride oleate (Span-80), fatty alcohol polyoxyethylene ether, sodium alkyl naphthalene sulfonate, sodium isooctanol succinate sulfonate, nonylphenol polyoxyethylene ether phosphate, and castor oil polyoxyethylene ether phosphate.

6. The thiazole zinc-containing synergistic bactericidal composition according to claim 4, characterized in that, The dispersant comprises one or more of the following: glycerol fatty acid polyoxyethylene ether, polyoxyethylene alkyl aryl ether, sodium lignosulfonate, naphthalene sulfonate formaldehyde condensate, fatty alcohol polyoxyethylene ether sulfate, naphthalene sulfonate formaldehyde condensate, sodium naphthalene sulfonate formaldehyde condensate, nonylphenol polyoxyethylene ether, polyoxyethylene lanolin alcohol, alkylphenol polyoxyethylene ether formaldehyde condensate, fatty alcohol polyoxyethylene ether, fatty alcohol polyoxyethylene ether phosphate, polyoxyethylene sorbitan fatty acid ester, and phosphate ester. The wetting agent includes one or more of the following: trisiloxane polyoxyethylene ether, sodium N-lauroyl glutamate, sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium methylnaphthalene sulfonate formaldehyde condensate, castor oil polyoxyethylene ether, triphenylethylphenol polyoxyethylene ether, sodium dodecylbenzene sulfonate, sodium alkylnaphthalene sulfonate, sodium isooctanol succinate sulfonate, polyoxyethylene alkyl aryl ether, fatty alcohol polyether glycerol fatty acid polyoxyethylene ether, and fatty alcohol polyoxyethylene ether. The binder includes one or more of xanthan gum, starch, urea-formaldehyde resin, gelatin, gum arabic, carboxymethyl cellulose, carboxyethyl cellulose, and polyvinyl alcohol; The disintegrant includes one or more of sodium bicarbonate, ammonium sulfate, sodium sulfate, calcium sulfate, and magnesium chloride; The thickener includes one or more of magnesium aluminum silicate, polyvinyl acetate, xanthan gum, gelatin, gum arabic, and polyvinyl alcohol; The defoamer includes one or more of silicone oil, n-octanol, silicone, butyl phosphate, and isobutyl phosphate; The antifreeze agent includes one or more of propylene glycol, ethylene glycol, and glycerol; The stabilizer includes one or more of triethanolamine, epichlorohydrin, butyl glycidyl ether, triphenyl phosphite, N-soybean oil-based trimethylenediamine, and dialkyl succinate acesulfonate. The filler includes solid filler and liquid filler, wherein the solid filler includes one or more of kaolin, attapulgite, diatomaceous earth, silica, bentonite, montmorillonite, calcium carbonate, and talc; and the liquid filler includes one or more of soybean oil, castor oil, and mineral oil.

7. The thiazole zinc-containing synergistic bactericidal composition according to claim 6, characterized in that, Thiazole zinc-containing synergistic bactericidal compositions are prepared into liquid or solid formulations; The liquid formulation contains 1% to 80% by weight of the effective active ingredient; The solid dosage form contains 5% to 80% of the effective active ingredient by weight.

8. The thiazole zinc-containing synergistic bactericidal composition according to claim 7, characterized in that, The liquid formulation includes at least one of the following: dispersible liquid, suspension, water-in-oil emulsion, microemulsion, suspension emulsion, microcapsule suspension, suspension seed coating agent, or emulsifiable concentrate; The solid dosage form includes at least one of water-dispersible granules, pellets, or wettable powders.

9. The application of a thiazole zinc-containing synergistic bactericidal composition according to any one of claims 1 to 8 in the prevention and control of bacterial diseases in agricultural production.

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