A dual-wire based triple lumen intracranial thrombectomy catheter

Abstract

This application relates to the field of medical device technology, specifically providing a three-lumen intracranial thrombus aspiration catheter based on dual guidewires. The catheter includes a main body with three independently and parallelly distributed three-lumen channels arranged axially within it. Each three-lumen channel includes: a guidewire operation chamber for delivering a microguidewire or thrombectomy stent; a guidewire positioning and adjustment chamber for accommodating a positioning guidewire to maintain vascular access; and a negative pressure suction chamber for connecting a negative pressure source to aspirate the thrombus. The negative pressure suction chamber is located between the guidewire operation chamber and the guidewire positioning and adjustment chamber. This allows for the coordinated operation of guidewire, guidewire positioning, and negative pressure suction within the same main body, avoiding multiple catheter replacements and addressing the limitation of single-function intracranial thrombus aspiration catheters in existing technologies, while improving the continuity and stability of the overall operation.

Description

Technical Field

[0001] This application relates to the field of medical device technology, and in particular to a three-lumen intracranial thrombus aspiration catheter based on dual guidewires. Background Technology

[0002] Cerebral embolism can trigger dangerous diseases such as stroke, and in severe cases, it can even be life-threatening. Among existing treatment methods, stent thrombectomy and catheter aspiration are two widely used approaches. Whether it's the mechanical interventional approach of stent thrombectomy or the minimally invasive procedure of catheter aspiration, the core principle is to use physical means to precisely remove the thrombus in the blood vessel, quickly open the blocked blood vessel channel, and restore smooth blood circulation, thereby achieving the treatment goal of improving the condition and saving lives.

[0003] In actual clinical practice, when multiple procedures such as lesion aspiration, stent delivery and deployment, and channel maintenance need to be performed sequentially, it is often necessary to change catheters of different functions multiple times. This repeated withdrawal and insertion of catheters not only prolongs the operation time and increases the complexity of the operation for medical staff, but may also cause repeated irritation or damage to the patient's tissues, increasing the surgical risk. At the same time, multiple catheter changes may also lead to channel loss or displacement, thereby affecting the accuracy and stability of subsequent operations and reducing the overall treatment effect.

[0004] Therefore, existing technologies have defects and shortcomings, and need further improvement and development. Summary of the Invention

[0005] In view of the shortcomings of the prior art, the purpose of this application is to provide a three-lumen intracranial thrombus aspiration catheter based on dual guidewires, which aims to solve the problem that the intracranial thrombus aspiration catheters in the prior art have relatively limited functions.

[0006] The technical solution adopted by this application to solve the technical problem is as follows: A three-lumen intracranial thrombus aspiration catheter based on dual guidewires, used for intracranial thrombectomy, the three-lumen intracranial thrombus aspiration catheter based on dual guidewires includes a tube body, and the tube body has three independent and parallel three-lumen channels arranged along the axial direction inside, the three-lumen channels including: The guidewire operating chamber is used to deliver microguidewires or thrombectomy stents. The positioning guidewire adjustment lumen is used to accommodate the positioning guidewire to maintain vascular access. The negative pressure suction chamber is used to connect to a negative pressure source to aspirate thrombi; The negative pressure adsorption chamber is located between the guidewire operation chamber and the positioning guidewire control chamber.

[0007] Optionally, the guidewire operating cavity and the guidewire positioning adjustment cavity are symmetrically arranged on the cross-section of the main body of the catheter to reduce the window sill effect generated by the catheter at the bend of the blood vessel.

[0008] Optionally, the inner diameter of the guidewire operating cavity and the inner diameter of the positioning guidewire control cavity are both smaller than the inner diameter of the negative pressure adsorption cavity.

[0009] Optionally, the dual-guidewire-based three-lumen intracranial thrombus aspiration catheter further includes an operating segment, which is integrally formed with the main body of the catheter. The operating segment includes a square handle, a microguidewire, a main guidewire, and an aspiration tube. The microguidewire is located on one side of the square handle, the main guidewire is located on the other side of the square handle, and the aspiration tube is located between the microguidewire and the main guidewire. The microguidewire tube is connected to the positioning guidewire control cavity; the guidewire operation cavity is connected to the main guidewire tube; and the negative pressure adsorption cavity is connected to the suction tube.

[0010] Optionally, an inwardly recessed step is provided on the side of the tube body away from the operating tube section, and the inwardly recessed step is set as the outlet of the positioning guidewire control cavity and the guidewire operating cavity.

[0011] Optionally, the tube body is set to 1.8mm~2mm; the guidewire operating cavity is set to 0.58mm~0.62mm; and the positioning guidewire adjustment cavity is set to have an inner diameter of 0.43mm~0.50mm.

[0012] Optionally, the distal outlet of the guidewire operating chamber and the distal outlet of the positioning guidewire control chamber are offset proximally by 2-4 mm relative to the distal opening of the negative pressure adsorption chamber.

[0013] Optionally, the distal end of the main body of the catheter is provided with a flexible segment of 8-10 cm, which is used to improve the catheter's ability to pass through curved blood vessels.

[0014] Optionally, the hardness of the flexible segment gradually decreases along the direction away from the operating pipe section, forming a gradually compliant pipe section.

[0015] Optionally, a non-transparent ring is provided at the end of the tube body away from the operating tube segment, the non-transparent ring being used to identify the position of the end of the tube body in the intracranial blood vessel.

[0016] Beneficial effects: This application provides a three-lumen intracranial thrombus aspiration catheter based on dual guidewires. The catheter features independently and parallelly arranged guidewire operation chambers, guidewire positioning and control chambers, and negative pressure adsorption chambers within its main body. The negative pressure adsorption chamber is positioned between the guidewire operation chamber and the guidewire positioning and control chamber. The guidewire operation chamber is used for delivering microguidewires or thrombectomy stents; the guidewire positioning and control chamber accommodates the guidewire to maintain vascular access; and the negative pressure adsorption chamber connects to a negative pressure source for thrombus aspiration. This allows for the coordinated operation of guidewires, guidewire positioning and control, and negative pressure adsorption within the same main body, avoiding multiple catheter replacements. This addresses the problem of limited functionality in existing intracranial thrombus aspiration catheters and improves the continuity and stability of the overall operation. Attached Figure Description

[0017] Figure 1 This is a three-dimensional structural schematic diagram of the three-lumen intracranial thrombus aspiration catheter based on dual guidewires provided in this application; Figure 2 This is another three-dimensional exploded structural diagram of the three-lumen intracranial thrombus aspiration catheter based on dual guidewires provided in this application; Figure 3 This is a side view of the three-lumen intracranial thrombus aspiration catheter based on dual guidewires provided in this application; Figure 4 It is in this application Figure 4 A cross-sectional view along the I-I direction.

[0018] Figure 5 This is a cross-sectional view of the working state of the three-lumen intracranial thrombus aspiration catheter based on dual guidewires provided in this application.

[0019] Explanation of reference numerals in the attached figures: 10. Three-lumen intracranial thrombus aspiration catheter based on dual guidewires; 11. Tube body; 111. Recessed step; 12. Three-lumen channel; 121. Guidewire operating lumen; 122. Positioning guidewire control lumen; 123. Negative pressure suction lumen; 13. Operating segment; 131. Square handle; 132. Microguidewire cannula; 133. Main guidewire cannula; 134. Aspiration cannula; 135. Non-transmissive ring. Detailed Implementation

[0020] To make the objectives, technical solutions, and advantages of this application clearer and more explicit, the following detailed description of this application is provided with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of this application and are not intended to limit this application.

[0021] In the description of this application, it should be understood that the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicating orientation or positional relationships based on the orientation or positional relationships shown in the accompanying drawings, are used only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation on this application. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this application, unless otherwise stated, "a plurality of" means two or more.

[0022] In the description of this application, it should be noted that, unless otherwise expressly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection between two components. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0023] Please refer to the following: Figures 1 to 5This application provides a three-lumen intracranial thrombus aspiration catheter 10 based on dual guidewires. The catheter 10 comprises a main body 11 and an integrally formed operating section 13. The main body 11 has independently and parallelly distributed three-lumen channels 12 along its axial direction. Each three-lumen channel 12 includes a guidewire operating chamber 121, a guidewire positioning and control chamber 122, and a negative pressure suction chamber 123. The negative pressure suction chamber 123 is located between the guidewire operating chamber 121 and the guidewire positioning and control chamber 122. The operating section 13 includes an operating head, a micro guidewire tube 132, a main guidewire tube 133, and a suction tube 134. The micro guidewire tube 132 communicates with the guidewire positioning and control chamber 122, the main guidewire tube 133 communicates with the guidewire operating chamber 121, and the suction tube 134 communicates with the negative pressure suction chamber 123. The guidewire operating chamber 121 and the positioning guidewire control chamber 122 are symmetrically arranged on the cross-section of the tube body 11, and the inner diameter of both is smaller than the inner diameter of the negative pressure adsorption chamber 123. An inwardly recessed step 111 is provided on the side of the tube body 11 away from the operating tube section 13, serving as the outlet structure for the guidewire operating chamber 121 and the positioning guidewire control chamber 122. The distal outlets of the guidewire operating chamber 121 and the positioning guidewire control chamber 122 are offset proximally by 2-4 mm relative to the distal opening of the negative pressure adsorption chamber 123. Furthermore, a flexible soft segment with a length of 8-10 cm is provided at the distal end of the tube body 11, and the hardness of the flexible soft segment gradually decreases along the direction away from the operating tube section 13, forming a gradually compliant tube segment. An opaque ring 135 is also provided at the distal end of the tube body 11 for marking the position.

[0024] In the specific operation, under the dual guidance of cerebrovascular imaging examinations (such as CTA or MRA) and digital subtraction angiography (DSA), the operator first inserts the positioning guidewire into the positioning guidewire control lumen 122 via the microguidewire tube 132 and extends it to the target vessel location. The presence of the positioning guidewire within the vessel maintains continuous vascular access. Simultaneously, the microguidewire or thrombectomy stent enters the guidewire operation lumen 121 through the main guidewire tube 133 and is delivered to the location of the thrombus. Because the guidewire operation lumen 121 and the positioning guidewire control lumen 122 are symmetrically arranged and form a dual guidewire pathway structure, the two guidewires provide guidance and support respectively during the advancement of the main tube body 11, making the advancement of the main tube body 11 more stable within the tortuous vessel, thereby reducing the window effect and improving the efficiency of placement.

[0025] After the guidewire operating chamber 121 delivers the microguidewire or thrombectomy stent to the thrombus location, the thrombectomy stent can be released through the guidewire operating chamber 121. While the stent encapsulates or interlocks with the thrombus, the negative pressure suction chamber 123 is connected to a negative pressure source via the suction tube 134, continuously suctioning the thrombus under negative pressure. Because the inner diameter of the negative pressure suction chamber 123 is larger than that of the guidewire operating chamber 121 and the guidewire positioning control chamber 122, a larger suction flow rate can be generated, thereby improving the thrombus removal efficiency. Simultaneously, the distal outlets of the guidewire operating chamber 121 and the guidewire positioning control chamber 122 are offset proximally by 2–4 mm relative to the distal opening of the negative pressure suction chamber 123. This allows the opening of the negative pressure suction chamber 123 to preferentially act on the thrombus area, reducing interference from the guidewire and thrombectomy stent on the suction flow field during suction, thereby improving the suction effect and reducing the risk of thrombus dislodgement.

[0026] Throughout the thrombectomy process, the positioning guidewire remains within the positioning guidewire control chamber 122 to maintain vascular access continuity. Even after the microguidewire or thrombectomy stent is withdrawn from the guidewire operation chamber 121, the procedure can be quickly resumed using the positioning guidewire, thus avoiding access loss due to repeated catheter changes. Simultaneously, the inward-reducing step 111 serves as the outlet structure for both the guidewire operation chamber 121 and the positioning guidewire control chamber 122, creating a relatively inward-reducing outlet shape at the distal end of both chambers. This helps reduce direct impact on the guidewire during aspiration in the negative pressure suction chamber 123 and further stabilizes the guidewire position.

[0027] In addition, the flexible soft segment at the distal end of the main body 11 provides good compliance when entering a tortuous blood vessel. As its rigidity gradually decreases along the direction away from the operating segment 13, it gradually adapts to the tortuous shape of the blood vessel during advancement, thereby improving passability and reducing irritation to the blood vessel wall. The non-transparent ring 135 is used to mark the position of the distal end of the main body 11 during operation, enabling the operator to accurately determine the relative positional relationship between the catheter and the thrombus, thereby improving the accuracy of operation.

[0028] Through the cooperation of the above structures, the guidewire operation chamber 121, the guidewire positioning and adjustment chamber 122, and the negative pressure adsorption chamber 123 work together within the same tube body 11, enabling thrombus aspiration, thrombectomy stent delivery and release, and vascular access maintenance to be completed in the same device. This avoids the need for multiple catheter replacements, effectively solves the problem of the limited functionality of intracranial thrombus aspiration catheters in the prior art, and improves the stability and efficiency of thrombectomy operations.

[0029] Please refer to the following: Figures 1 to 2In some embodiments, the dual-guidewire-based three-lumen intracranial thrombus aspiration catheter 10 includes a tube body 11, inside which are independently and parallelly distributed three-lumen channels 12. The three-lumen channels 12 include: a guidewire operation chamber 121, a guidewire positioning and control chamber 122, and a negative pressure adsorption chamber 123. The guidewire operation chamber 121 is used for delivering microguidewires or thrombectomy stents. The guidewire positioning and control chamber 122 is used to accommodate the positioning guidewire to maintain vascular access. The negative pressure adsorption chamber 123 is used to connect to a negative pressure source for thrombus aspiration. The negative pressure adsorption chamber 123 is located between the guidewire operation chamber 121 and the guidewire positioning and control chamber 122. Furthermore, by axially distributing independent and parallel guidewire operation chamber 121, guidewire positioning and control chamber 122, and negative pressure adsorption chamber 123 within the main body 11 of the catheter, and positioning and control chamber 122, the negative pressure adsorption chamber 123 is positioned between the guidewire operation chamber 121 and the guidewire positioning and control chamber 122. The guidewire operation chamber 121 is used for delivering microguidewires or thrombectomy stents, the guidewire positioning and control chamber 122 is used to accommodate the positioning guidewire to maintain vascular access, and the negative pressure adsorption chamber 123 is used to connect to a negative pressure source for thrombus aspiration. Thus, guidewire operation, guidewire positioning and control, and negative pressure adsorption are achieved synergistically within the same main body 11, avoiding multiple catheter replacements. This solves the problem of the limited functionality of intracranial thrombus aspiration catheters in the prior art and improves the continuity and stability of the overall operation.

[0030] Please refer to the following: Figures 1 to 2 In some embodiments, the guidewire operating cavity 121 and the positioning guidewire control cavity 122 are symmetrically arranged on the cross-section of the tube body 11 to reduce the window sill effect generated by the catheter at the bend of the blood vessel. Furthermore, by symmetrically arranging the guidewire operating cavity 121 and the positioning guidewire control cavity 122 on the cross-section of the tube body 11, a balanced distribution is achieved. This provides symmetrical support when the tube body 11 enters the bend of the blood vessel, thereby reducing the window sill effect generated by the tube body 11 at the bend of the blood vessel, improving the stability of the tube body 11 in the blood vessel, and further enhancing the synergistic working effect of the guidewire operating cavity 121 and the positioning guidewire control cavity 122.

[0031] Please refer to the following: Figures 1 to 2In some embodiments, the inner diameters of the guidewire operating cavity 121 and the positioning guidewire control cavity 122 are both smaller than the inner diameter of the negative pressure adsorption cavity 123. Furthermore, by setting the inner diameters of both the guidewire operating cavity 121 and the positioning guidewire control cavity 122 to be smaller than the inner diameter of the negative pressure adsorption cavity 123, the negative pressure adsorption cavity 123 has a larger flow space, enabling a larger suction flow rate when connected to a negative pressure source, thereby improving the adsorption capacity for thrombi. Simultaneously, it avoids interference between the guidewire operating cavity 121 and the positioning guidewire control cavity 122 and the flow in the negative pressure adsorption cavity 123, further enhancing the negative pressure adsorption efficiency.

[0032] Please refer to the following: Figures 1 to 2 In some embodiments, the three-lumen intracranial thrombus aspiration catheter 10 based on dual guidewires further includes an operating section 13, which is integrally formed with the main body 11. The operating section 13 includes a square handle 131, a micro guidewire tube 132, a main guidewire tube 133, and an aspiration tube 134. The micro guidewire tube 132 is disposed on one side of the square handle 131, the main guidewire tube 133 is disposed on the other side of the square handle 131, and the aspiration tube 134 is disposed between the micro guidewire tube 132 and the main guidewire tube 133. The micro guidewire tube 132 is connected to the positioning guidewire control chamber 122; the guidewire operating chamber 121 is connected to the main guidewire tube 133, and the negative pressure suction chamber 123 is connected to the aspiration tube 134. Furthermore, by setting up an operation tube section 13 integrally formed with the tube body 11, and setting an operation head, micro guidewire tube 132, main guidewire tube 133 and suction tube 134 on the operation tube section 13, and simultaneously connecting the micro guidewire tube 132 with the positioning guidewire control chamber 122, the main guidewire tube 133 with the guidewire operation chamber 121, and the suction tube 134 with the negative pressure adsorption chamber 123, the guidewire operation chamber 121, the positioning guidewire control chamber 122 and the negative pressure adsorption chamber 123 are effectively connected with external operations, so that the delivery of micro guidewire or thrombectomy support, the maintenance of positioning guidewire and negative pressure adsorption can be carried out independently through the corresponding channels, thereby improving the coordination and controllability of the overall operation.

[0033] Please refer to the following: Figures 1 to 2In some embodiments, an inwardly recessed step 111 is provided on the side of the tube body 11 away from the operating tube section 13. The inwardly recessed step 111 serves as the outlet of the positioning guidewire control cavity 122 and the guidewire operation cavity 121. Furthermore, by providing an inwardly recessed step 111 on the side of the tube body 11 away from the operating tube section 13, and setting the inwardly recessed step 111 as the outlet of the positioning guidewire control cavity 122 and the guidewire operation cavity 121, the guidewire operation cavity 121 and the positioning guidewire control cavity 122 form an inwardly recessed structure at their distal ends. This reduces the direct impact on the guidewire during suction in the negative pressure adsorption cavity 123, thereby improving the stability of the guidewire in the positioning guidewire control cavity 122 and further enhancing the suction effect of the negative pressure adsorption cavity 123.

[0034] In some embodiments, the tube body 11 is set to 1.8mm~2mm, or 1.8mm~4mm; the guidewire operating cavity 121 is set to 0.58mm~0.62mm; and the positioning guidewire control cavity 122 is set to have an inner diameter of 0.43mm~0.50mm. Furthermore, by setting the tube body 11 to 1.8mm~2mm, the guidewire operating cavity 121 to 0.58mm~0.62mm, and the positioning guidewire control cavity 122 to an inner diameter of 0.43mm~0.50mm, the guidewire operating cavity 121 and the positioning guidewire control cavity 122 can be adapted to microguidewires or thrombectomy stents and positioning guidewires respectively. This ensures that the overall size of the tube body 11 can enter intracranial blood vessels while achieving multi-channel functional allocation, further enhancing the collaborative working ability of the guidewire operating cavity 121 and the positioning guidewire control cavity 122. Specifically, the above dimensions can be flexibly selected to adapt to the cerebrovascular conditions of different patients and will not become an obstacle to achieving the core functions of this application.

[0035] Please refer to the following: Figures 1 to 2 In some embodiments, the distal outlets of the guidewire operating chamber 121 and the positioning guidewire control chamber 122 are offset proximally by 2-4 mm relative to the distal opening of the negative pressure adsorption chamber 123. Furthermore, by offsetting the distal outlets of the guidewire operating chamber 121 and the positioning guidewire control chamber 122 proximally by 2-4 mm relative to the distal opening of the negative pressure adsorption chamber 123, the distal opening of the negative pressure adsorption chamber 123 can preferentially act on the thrombus area. This reduces interference from the microguidewire or thrombectomy stent in the guidewire operating chamber 121 and the positioning guidewire in the positioning guidewire control chamber 122 on the aspiration flow during negative pressure adsorption, thereby improving the aspiration efficiency of the negative pressure adsorption chamber 123 and reducing the risk of thrombus dislodgement.

[0036] In some embodiments, the distal end of the catheter body 11 is provided with a flexible segment of 8-10 cm, which is used to improve the catheter's ability to pass through curved blood vessels. Furthermore, by providing an 8-10 cm flexible segment at the distal end of the catheter body 11, the catheter body 11 has good compliance when entering curved blood vessels, thereby improving its ability to pass through curved blood vessels. This further ensures that the guidewire operating chamber 121, the guidewire positioning and adjustment chamber 122, and the negative pressure suction chamber 123 can smoothly reach the target position, improving the overall success rate of the operation.

[0037] In some embodiments, the stiffness of the flexible segment gradually decreases along the direction away from the operating tube segment 13, forming a gradually compliant tube segment. Furthermore, by gradually decreasing the stiffness of the flexible segment along the direction away from the operating tube segment 13 to form a gradually compliant tube segment, the tube body 11 gradually adapts to the tortuous shape of the blood vessel during advancement, thereby reducing stimulation to the blood vessel while ensuring advancement, and further improving the safety and stability of the tube body 11 within the blood vessel.

[0038] Please refer to the following: Figures 4 to 5 In some embodiments, a non-transparent ring 135 is provided at the end of the tube body 11 away from the operating tube segment 13. The non-transparent ring 135 is used to mark the position of the end of the tube body 11 in the intracranial blood vessel. Furthermore, by providing a non-transparent ring 135 at the end of the tube body 11 away from the operating tube segment 13, and using the non-transparent ring 135 to mark the position of the end of the tube body 11 in the intracranial blood vessel, the operator can clearly determine the positional relationship between the tube body 11 and the thrombus, thereby improving the operational precision of the guidewire operating lumen 121, the guidewire positioning adjustment lumen 122, and the negative pressure suction lumen 123, and further enhancing the accuracy and reliability of the overall thrombectomy operation.

[0039] In some embodiments, the tube body is divided sequentially from the distal end to the proximal end into a distal guiding section, an intermediate control section, and a proximal force transmission section. The distal guiding section is used to enter tortuous intracranial blood vessels, the intermediate control section is used to control guidewire movement and adjust the flow field, and the proximal force transmission section is used to transmit the pushing force and torque applied by the operator to the distal end.

[0040] In some embodiments, the distal guide segment is 6–12 cm in length and employs a flexible, gradually varying structure, with its stiffness increasing progressively from distal to proximal. This allows the tube body to have good compliance when entering the tortuous area of ​​the blood vessel, while providing sufficient support during advancement. The outermost end of the distal guide segment has a smooth transition structure to reduce irritation to the inner wall of the blood vessel.

[0041] In some embodiments, a guidewire guiding region is provided inside the distal guiding segment. This guidewire guiding region is not a regular circular cross-section, but rather an asymmetrical cross-sectional structure that gradually changes along the axial direction. Near the distal end, the cross-section of the guidewire guiding region is approximately elliptical and offset to one side of the vessel body. This creates a pre-deflection tendency for the guidewire at the exit position, making it easier for the guidewire to adhere to the vessel wall and advance, thus improving the guidewire's ability to selectively enter the target vessel branch.

[0042] In some embodiments, as the guide wire guiding region extends further proximally along the axial direction, its cross-section gradually transitions from an elliptical shape to an irregular polygonal structure. The boundaries of this irregular polygon are not uniformly distributed but rather have locally concave and convex structures, thus creating intermittent contact points during guide wire passage. This prevents the guide wire from oscillating freely during advancement, instead maintaining relative stability under the constraint of multiple discontinuous support points, thereby significantly improving control precision.

[0043] In some embodiments, the intermediate control section contains a guidewire stabilizing structure, which includes multiple guide protrusion units spaced apart along the axial direction. These guide protrusion units are asymmetrically distributed circumferentially. Specifically, at certain axial positions, guide protrusions are provided only on one side of the tube wall, while none are provided on the other side, thus creating an offset contact for the guidewire at that position. At other axial positions, they are provided on opposite sides, forming an alternating offset structure. Furthermore, the asymmetrically distributed guide protrusion units allow the guidewire to form a controlled, wave-like path during advancement, preventing free swaying of the guidewire within the tube lumen, reducing continuous friction between the guidewire and the tube wall, and improving handling feel.

[0044] In some embodiments, the height of the guide protrusion units is 0.01–0.05 mm, their spacing is 1–5 mm, and they are non-uniformly arranged according to different axial regions. Specifically, the guide protrusion units are arranged more densely near the distal guide section to enhance the guide wire control capability; while near the proximal force transmission section, the spacing of the guide protrusion units gradually increases to reduce resistance and improve guide wire advance efficiency.

[0045] In some embodiments, the intermediate control section is further provided with a flow field adjustment structure to optimize the flow path of blood and thrombus fragments during aspiration. The flow field adjustment structure includes a spiral microstructure disposed on the inner wall of the tube body. This spiral microstructure is not continuously and uniformly distributed, but exhibits different pitches and directions of rotation in different axial segments.

[0046] Specifically, in the distal region, the pitch of the helical structure is smaller to enhance fluid turbulence and thus improve the thrombus removal effect; while in the proximal region, the pitch gradually increases to reduce flow resistance and allow thrombus fragments to be smoothly aspirated and discharged.

[0047] In some embodiments, the spiral direction of the spiral microstructure can change in different axial regions, for example, clockwise in the first segment and counterclockwise in the second segment, thereby forming a local turbulent region, making it difficult for thrombi to adhere to the vessel wall and improving aspiration efficiency.

[0048] In some embodiments, the proximal force transmission section is configured with a relatively regular channel structure to reduce overall flow resistance and ensure negative pressure transmission efficiency. The wall thickness of the proximal force transmission section is relatively increased to improve its compressive strength, making it less prone to collapse when connected to negative pressure equipment.

[0049] In some embodiments, different axial regions of the tube body are prepared using different materials or composite materials with different proportions. For example, the distal guiding section uses a material with lower hardness to improve flexibility; the intermediate control section uses a material with medium hardness to balance flexibility and support; and the proximal force transmission section uses a material with higher hardness to improve the ability to transmit pushing force.

[0050] In some embodiments, the inner wall material of the guide wire guiding region is surface-treated to create different frictional properties. For example, a relatively high coefficient of friction is formed in the region where the guide protrusion unit is located to enhance guiding capability; while a lower coefficient of friction is maintained in the non-contact region to reduce overall resistance.

[0051] In some embodiments, the various structures on the inner wall of the tube body are formed by an integral molding process or by a post-processing process, thereby ensuring the continuity and reliability of the structure and avoiding loosening or detachment of the structure due to assembly.

[0052] In some embodiments, the functional structures of the tube body cooperate with each other, wherein the guide wire guiding area is used for initial guidance, the guide protrusion unit is used for mid-section stabilization control, and the flow field adjustment structure is used to optimize the suction effect. The three work together to achieve the synergy of precise control of two guide wires and efficient suction in a single conduit structure.

[0053] In some embodiments, the tube body can be flexibly made of existing materials and processes such as PEBAX (polyether block amide), nylon 11, polyvinyl chloride (PVC), or TPU (thermoplastic polyurethane), and this application does not impose any limitations. Stainless steel braided wires / springs can be embedded in the catheter to enhance its pressure resistance and collapse resistance, preventing deformation during negative pressure aspiration. Alternatively, a nickel-titanium alloy braided layer can be embedded in the intracranial aspiration catheter, balancing flexibility and support, making it less prone to breakage when passing through tortuous blood vessels.

[0054] In some embodiments, the non-transparent ring 135 contains materials such as platinum-iridium alloy, platinum-tungsten alloy, and tantalum, and is integrated into the tip of the catheter or a key part to ensure clear visibility under X-ray.

[0055] In some embodiments, the finished product of the dual-guidewire-based three-lumen intracranial thrombus aspiration catheter 10 is sterilized with ethylene oxide to ensure single-use safety.

[0056] In summary, this application provides a three-lumen intracranial thrombus aspiration catheter based on dual guidewires. The three-lumen intracranial thrombus aspiration catheter based on dual guidewires includes a tube body, inside which are independently and parallelly distributed three-lumen channels along the axial direction. The three-lumen channels include: a guidewire operation chamber, a guidewire positioning and control chamber, and a negative pressure adsorption chamber. The guidewire operation chamber is used for delivering microguidewires or thrombectomy stents. The guidewire positioning and control chamber is used to accommodate the positioning guidewire to maintain vascular access. The negative pressure adsorption chamber is used to connect a negative pressure source to aspirate thrombi. The negative pressure adsorption chamber is located between the guidewire operation chamber and the guidewire positioning and control chamber. Furthermore, by axially distributing independent and parallel guidewire manipulation chambers, guidewire positioning and control chambers, and negative pressure adsorption chambers within the main body of the catheter, and positioning the guidewire manipulation chamber between the guidewire manipulation chamber and the guidewire positioning and control chamber, the guidewire manipulation chamber is used for delivering microguidewires or thrombectomy stents, the guidewire positioning and control chamber is used to accommodate the guidewire to maintain vascular access, and the negative pressure adsorption chamber is used to connect to a negative pressure source for thrombus aspiration. This allows for the coordinated operation of guidewire manipulation, guidewire positioning and control, and negative pressure adsorption within the same main body of the catheter, avoiding multiple catheter replacements. This solves the problem of the limited functionality of existing intracranial thrombus aspiration catheters and improves the continuity and stability of the overall operation.

[0057] It should be understood that the application of this application is not limited to the examples above. Those skilled in the art can make improvements or modifications based on the above description, and all such improvements and modifications should fall within the protection scope of the appended claims.

Claims

1. A three-lumen intracranial thrombus aspiration catheter based on dual guidewires, used for intracranial thrombectomy, characterized in that, The dual-guidewire-based three-lumen intracranial thrombus aspiration catheter includes a main body, within which three independent and parallel three-lumen channels are arranged along the axial direction. Each three-lumen channel includes: The guidewire operating chamber is used to deliver microguidewires or thrombectomy stents. The positioning guidewire adjustment lumen is used to accommodate the positioning guidewire to maintain vascular access. The negative pressure suction chamber is used to connect to a negative pressure source to aspirate thrombi; The negative pressure adsorption chamber is located between the guidewire operation chamber and the positioning guidewire control chamber.

2. The three-lumen intracranial thrombus aspiration catheter based on dual guidewires according to claim 1, characterized in that, The guidewire operating cavity and the guidewire positioning adjustment cavity are symmetrically arranged on the cross-section of the main body of the catheter to reduce the window sill effect generated by the catheter at the bend of the blood vessel.

3. The three-lumen intracranial thrombus aspiration catheter based on dual guidewires according to claim 2, characterized in that, The inner diameter of the guidewire operating chamber and the inner diameter of the positioning guidewire control chamber are both smaller than the inner diameter of the negative pressure adsorption chamber.

4. The three-lumen intracranial thrombus aspiration catheter based on dual guidewires according to claim 3, characterized in that, The dual-guidewire-based three-lumen intracranial thrombus aspiration catheter also includes an operating section, which is integrally formed with the main body of the catheter. The operating section includes a square handle, a microguidewire, a main guidewire, and an aspiration tube. The microguidewire is located on one side of the square handle, the main guidewire is located on the other side of the square handle, and the aspiration tube is located between the microguidewire and the main guidewire. The microguidewire tube is connected to the positioning guidewire control cavity; the guidewire operation cavity is connected to the main guidewire tube; and the negative pressure adsorption cavity is connected to the suction tube.

5. The three-lumen intracranial thrombus aspiration catheter based on dual guidewires according to claim 4, characterized in that, An inwardly recessed step is provided on the side of the main body of the tube away from the operating tube section. The inwardly recessed step serves as the outlet of the positioning guidewire control cavity and the guidewire operating cavity.

6. The three-lumen intracranial thrombus aspiration catheter based on dual guidewires according to claim 4, characterized in that, The main body of the tube is set to 1.8mm~2mm; the guide wire operating cavity is set to 0.58mm~0.62mm; and the positioning guide wire adjustment cavity is set to have an inner diameter of 0.43mm~0.50mm.

7. The three-lumen intracranial thrombus aspiration catheter based on dual guidewires according to claim 5, characterized in that, The distal outlet of the guidewire operating chamber and the distal outlet of the positioning guidewire control chamber are offset proximally by 2-4 mm relative to the distal opening of the negative pressure adsorption chamber.

8. The three-lumen intracranial thrombus aspiration catheter based on dual guidewires according to claim 2, characterized in that, The distal end of the main tube body is configured with a flexible segment of 8-10 cm, which is used to improve the catheter's ability to pass through curved blood vessels.

9. The three-lumen intracranial thrombus aspiration catheter based on dual guidewires according to claim 8, characterized in that, The hardness of the flexible section gradually decreases along the direction away from the operating pipe section, forming a gradually compliant pipe section.

10. The three-lumen intracranial thrombus aspiration catheter based on dual guidewires according to claim 9, characterized in that, A non-transparent ring is provided at the end of the main body of the tube away from the operating tube segment. The non-transparent ring is used to mark the position of the end of the main body of the tube in the intracranial blood vessels.

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