Multifunctional small animal anesthesia experiment device

Abstract

This invention discloses a multifunctional small animal anesthesia experimental device, comprising: a mounting base, a support column, an experimental chamber, a plug assembly, and an elastic rubber ring. The lower side of the support column is fixed to the upper surface of the mounting base; the top of the support column is integrally connected to the lower wall of the experimental chamber; the top of the experimental chamber has a top hatch; an anesthetic gas inlet connector is located on the left side wall of the experimental chamber; a tail protrusion tube is located on the right side wall of the experimental chamber; the plug assembly includes a first elastic plug matching the anesthetic gas inlet connector and a second elastic plug matching the tail protrusion tube; one end of the elastic rubber ring has a threaded tube with an internal thread structure, and the inner diameter of the elastic rubber ring is smaller than that of the threaded tube. This invention allows for timely replenishment of anesthetic gas during the experiment, ensuring the experimental animal remains anesthetized; and allows the tail of the experimental mouse to extend outside the experimental chamber via the tail protrusion tube for blood collection.

Description

Technical Field

[0001] This invention relates to the field of animal experimental equipment technology, and in particular to a multifunctional small animal anesthesia experimental device. Background Technology

[0002] Clinically, current small animal gas anesthesia experiments primarily utilize inhalation anesthesia methods such as isoflurane / sevoflurane to rapidly anesthetize experimental animals. In practice, to avoid passive exposure of researchers to anesthetic gases during experiments, the current method involves anesthetizing the animal and then placing it in a container before conducting the experimental procedures. The problem with this approach is that, due to the rapid metabolism and short duration of gas anesthesia, there is a possibility of anesthesia failure midway through the experiment. Therefore, developing a novel small animal anesthesia experimental device to overcome the aforementioned problems in existing technologies is a direction that requires further research by those skilled in the art. Summary of the Invention

[0003] The purpose of this invention is to provide a multifunctional small animal anesthesia experimental device that can avoid the problem of anesthesia failure in experimental mice during the experiment, while reducing the risk of laboratory personnel being exposed to anesthetic gases.

[0004] This invention provides a multifunctional small animal anesthesia experimental device, comprising:

[0005] The mounting base has a horizontal lower surface and is used to be placed on the ground or on a laboratory table.

[0006] A support column, which extends vertically and whose lower side is fixed to the upper surface of the mounting base;

[0007] The experimental chamber extends horizontally, with the top of the supporting column fixedly connected to the lower wall of the chamber. A top door is located at the top of the experimental chamber. An anesthetic gas inlet connector is located on one side wall of the experimental chamber. A tail protrusion tube is located on the other side wall of the experimental chamber, and the outer wall of the tail protrusion tube has an external thread structure. One end of the top door is hinged to the top of the experimental chamber via a hinge shaft, and the edge of the top door may also be equipped with a rubber strip for sealing. A door handle may also be provided on the surface of the top door.

[0008] A plug assembly, comprising a first resilient plug detachably mounted on the anesthetic gas inlet connector and a second resilient plug detachably mounted on the tail extension tube;

[0009] An elastic rubber ring has a threaded tube at one end, and the inner wall of the threaded tube has an internal thread structure that matches the external thread structure. The inner wall diameter of the elastic rubber ring is configured to be smaller than the inner wall diameter of the threaded tube.

[0010] This technical solution involves opening the top hatch and placing anesthetized mice into the experimental chamber for testing. During the experiment, the first elastic plug can be removed, and external anesthetic gas can be connected to the anesthetic gas inlet connector for secondary anesthesia, thus overcoming the problem of anesthesia failure. After the experiment, an external exhaust pump can be connected to the anesthetic gas inlet connector to extract the anesthetic gas. Simultaneously, the second elastic plug can be removed beforehand, allowing the mouse's tail to extend outside the experimental chamber through the tail extension tube for blood collection. Furthermore, during the blood collection process, an elastic rubber ring can be used to achieve an interference fit connection at the tail, reducing leakage of external anesthetic gas from the tail extension tube under pressure when it enters the experimental chamber through the anesthetic gas inlet connector, thereby preventing excessive exposure of the experimenter to anesthetic gas.

[0011] Preferably, in the above-mentioned small animal anesthesia experimental device, a side door is provided on the front side wall of the experimental chamber. The side door is generally rectangular, and one side is hinged to the side wall of the experimental chamber via a hinge shaft; a rubber strip may also be provided on the edge of the door to achieve a sealing effect. A door handle may also be provided on the surface of the side door.

[0012] This technical solution utilizes a side door located on the front wall of the experimental chamber to facilitate the experiment. It should be noted that, in practice, before performing this operation, the anesthetic gas must first be drawn away using an external exhaust pump to prevent it from flowing into the outside air through the side door.

[0013] Preferably, in the above-mentioned small animal anesthesia experimental device, the anesthetic gas input connector is electrically connected to the mask interface extending into the experimental chamber; a horn-shaped mask is detachably installed on the mask interface.

[0014] By adopting this technical solution, when the top hatch is opened and the anesthetized experimental mouse is placed into the experimental chamber, a horn-shaped mask is installed on the mask interface and the head of the experimental mouse is aligned with the open end of the horn-shaped mask, thus ensuring that the anesthetic gas supplemented during the experiment is inhaled by the experimental mouse as soon as possible.

[0015] Preferably, in the above-mentioned small animal anesthesia experimental device, an electrothermal layer is installed on the inner bottom wall of the experimental chamber; a battery assembly is installed in the mounting base; and the battery assembly is electrically connected to the electrothermal layer via electrical wires. The battery assembly is used to supply power to the electrothermal layer. In practice, the electrothermal layer can be constructed using a graphene heating film or other similar heating elements.

[0016] By adopting this technical solution, the abdomen of the experimental mouse is kept warm through an electrothermal layer during the experiment, thereby ensuring the body temperature of the experimental mouse and helping to achieve stable operation of animal experiments over a long period of time.

[0017] Preferably, in the above-mentioned small animal anesthesia experimental device, the experimental chamber is in the shape of a semi-cylindrical structure; the top of the support column is fixedly connected to the horizontal surface of the semi-cylindrical structure; the tail extension tube and the anesthetic gas input connector are respectively located on the semi-circular end face of the experimental chamber.

[0018] By adopting this technical solution:

[0019] Compared with the prior art, the present invention has achieved the following technical advancements:

[0020] First, staff can replenish anesthetic gas in a timely manner during the experiment to ensure that the experimental animals remain under anesthesia.

[0021] Secondly, medical personnel can perform blood collection by extending the tail of the experimental mouse through the tail tube outside the experimental cavity during the experiment.

[0022] Finally, this product has a simple structure and is easy to prepare and implement. Attached Figure Description

[0023] Figure 1 This is a schematic diagram of the structure of Embodiment 1. The side door is obscured in this figure, and the first elastic plug, the second elastic plug, and the elastic rubber ring are omitted.

[0024] Figure 2 This is a side view of the structure of Example 1. In this figure, the elastic rubber ring, the first elastic plug, and the second elastic plug are all in a separate state.

[0025] Figure 3 This is a schematic diagram of the experimental cavity and its internal structure in Example 1.

[0026] The component names corresponding to the various reference numerals in the figure are as follows:

[0027] 100. Mounting base; 110. Battery cavity; 120. Battery pack; 111. Outer cover; 200. Support column; 300. Experimental chamber; 310. Top hatch; 320. Side door; 330. Heating layer; 340. Hinge shaft; 350. Rubber strip; 360. Door handle; 410. Anesthetic gas input connector; 420. Tail extension tube; 421. External thread structure; 430. Mask interface; 440. Horn-shaped mask; 510. First elastic plug; 520. Second elastic plug; 610. Elastic rubber ring; 620. Threaded tube; 630. Electrical wire. Detailed Implementation

[0028] The following specific examples illustrate the implementation of the present invention. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments, and various details in this specification can also be modified or changed based on different viewpoints and applications without departing from the spirit of the present invention.

[0029] Example 1, please refer to Figure 1-3 :

[0030] A multifunctional small animal anesthesia experimental device includes: a mounting base 100, a support column 200, an experimental chamber 300, a plug assembly, and an elastic rubber ring 610.

[0031] The lower surface of the mounting base 100 is horizontal, and the mounting base 100 is used to place on the ground or on an experimental table; the number of the support columns 200 is configured to be two or more, and each of the support columns 200 extends in a vertical direction; the lower side of the column of the support column 200 is fixed to the upper surface of the mounting base 100; the top of the column of the support column 200 is fixedly connected to the lower wall of the experimental chamber 300 as a whole.

[0032] In this example: the experimental chamber 300 has a semi-cylindrical structure; its horizontal plane is located on the lower side and is fixed to the top of the support column 200. A top hatch 310 is provided at the top of the arc-shaped surface of the experimental chamber 300; an anesthetic gas input connector 410 is provided on the semi-circular surface of the left side wall of the experimental chamber 300; the anesthetic gas input connector 410 is conductively connected to a mask interface 430 extending into the inside of the experimental chamber 300; a flared mask 440 is detachably mounted on the mask interface 430. A tail extension tube 420 is provided on the semi-circular surface of the right side wall of the experimental chamber 300, and an external thread structure 421 is provided on the outer wall of the tail extension tube 420; a side door 320 is also provided on the side wall of the experimental chamber 300. The top hatch 310 and the side door 320 are respectively connected to the arc-shaped surface of the experimental chamber 300 via hinge shafts 340. The top hatch 310 and the side door 320 may each be provided with rubber strips 350 to form an edge sealing structure. Door handles 360 may also be provided on the top hatch 310 and the side door 320. An electric heating layer 330 is also installed on the inner bottom wall of the experimental chamber 300.

[0033] The plug assembly includes a first elastic plug 510 detachably mounted on the anesthetic gas inlet connector 410 and a second elastic plug 520 detachably mounted on the tail extension tube 420; the first elastic plug 510 and the second elastic plug 520 are used to respectively block / open the anesthetic gas inlet connector 410 and the tail extension tube 420.

[0034] One end of the elastic rubber ring 610 is connected to a threaded tube 620 by heat pressing. The inner wall of the threaded tube 620 is provided with an internal thread structure that matches the external thread structure 421. The inner wall diameter of the elastic rubber ring 610 is configured to be smaller than the inner wall diameter of the threaded tube 620.

[0035] A battery cavity 110 is installed inside the mounting base 100. The surface of the battery cavity 110 is provided with an outer cover 111. A battery pack 120 is detachably installed inside the battery cavity 110. The battery pack 120 is electrically connected to the heating layer 330 through an electrical wire 630.

[0036] In practice, its working process is as follows:

[0037] First, open the top hatch 310 and install the horn-shaped mask 440 on the mask interface 430. Simultaneously, place the anesthetized mouse into the experimental chamber 300, aligning the mouse's head with the open end of the horn-shaped mask 440 to ensure that the anesthetic gas supplied during the experiment is inhaled by the mouse immediately. During the experiment, depending on the expected duration, remove the first elastic plug 510 and connect external anesthetic gas to the anesthetic gas inlet connector 410 for secondary anesthesia, thus overcoming the problem of anesthesia failure. After the experiment, connect an external exhaust pump to the anesthetic gas inlet connector 410 to extract the anesthetic gas. Additionally, the second elastic plug 520 can be removed beforehand, allowing the mouse's tail to extend out of the experimental chamber 300 through the tail extension tube 420. An elastic rubber ring 610 is used to achieve an interference fit connection to the tail, reducing leakage of external anesthetic gas from the tail extension tube 420 under pressure when it enters the experimental chamber 300 through the anesthetic gas inlet connector 410. Meanwhile, if the experiment is long, the outer cover 111 can be opened before the experimental mouse is placed in the experimental mouse, and the battery pack 120 can be installed in the battery cavity 110. This will allow the heating layer 330 to be heated, so that the experimental mouse's abdomen can be kept warm during the experiment, thereby ensuring the experimental mouse's body temperature and helping to achieve stable operation of animal experiments over a long period of time.

[0038] The embodiments of the present invention have been described in detail above with reference to the accompanying drawings, but the present invention is not limited to the above embodiments. Even if various changes are made to the present invention, if these changes fall within the scope of the claims of the present invention and their equivalents, they shall still fall within the protection scope of the present invention.

Claims

1. A multifunctional small animal anesthesia experimental device, characterized in that, include: The mounting base has a horizontal lower surface and is used to be placed on the ground or on a laboratory table. A support column, which extends vertically and whose lower side is fixed to the upper surface of the mounting base; An experimental chamber extends horizontally, and the top of the support column is fixedly connected to the lower wall of the experimental chamber. The top of the experimental chamber is provided with a top hatch. An anesthetic gas input connector is provided on one side wall of the experimental chamber. A tail extension tube is provided on the other side wall of the experimental chamber, and the outer wall of the tail extension tube is provided with an external thread structure. A plug assembly, comprising a first resilient plug detachably mounted on the anesthetic gas inlet connector and a second resilient plug detachably mounted on the tail extension tube; An elastic rubber ring has a threaded tube at one end, and the inner wall of the threaded tube has an internal thread structure that matches the external thread structure. The inner wall diameter of the elastic rubber ring is configured to be smaller than the inner wall diameter of the threaded tube.

2. The small animal anesthesia experimental apparatus according to claim 1, characterized in that, A side door is provided on the side wall of the experimental chamber.

3. The small animal anesthesia experimental apparatus according to claim 2, characterized in that, The anesthetic gas input connector is electrically connected to the mask interface that extends into the inside of the experimental chamber; a horn-shaped mask is detachably installed on the mask interface.

4. The small animal anesthesia experimental apparatus according to claim 3, characterized in that, An electric heating layer is installed on the inner bottom wall of the experimental chamber; A battery assembly is installed inside the mounting base; the battery assembly is electrically connected to the heating layer via electrical wires.

5. The small animal anesthesia experimental apparatus according to claim 4, characterized in that, The experimental chamber has a semi-cylindrical structure as a whole; The top of the support column is fixedly connected to the horizontal surface of the semi-cylindrical structure; the tail extension tube and the anesthetic gas input connector are respectively located on the semi-circular end face of the experimental chamber.

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