A low-stress dual-mode body fat detection device suitable for drug intervention in obese model small animals

Abstract

This invention discloses a low-stress bimodal body fat detection device suitable for drug intervention in obese small animals. The device includes a detection platform component and first limiting components, with the first limiting components slidably installed at each of the four diagonal points on the top of the detection platform component. This low-stress bimodal body fat detection device for drug intervention in obese small animals allows for flexible adjustment of the limiting space according to the animal's body shape through the cooperation of its components. This avoids shaking affecting the detection results while preventing excessive restraint, reducing animal stress response and minimizing the interference of stress on the drug intervention experimental results. The device integrates both ultrasound and conductivity detection modalities for body fat detection, simultaneously acquiring data on fat layer thickness and total body fat percentage. Bimodal detection can be completed without changing the device, reducing the number of animal transfers, further reducing the possibility of stress, and improving detection efficiency. It can meet the experimental needs of repeated detection during long-term drug intervention.

Description

Technical Field

[0001] This invention relates to the field of animal experimental technology, specifically to a low-stress dual-modal body fat detection device suitable for drug intervention in obese small animals. Background Technology

[0002] Animal experiments are biological and medical scientific research activities conducted in a laboratory by professionally trained personnel using standardized laboratory animals. The core purpose is to acquire new knowledge in life sciences, test product safety, explore the mysteries of human life, and overcome disease challenges.

[0003] When conducting animal experiments, it is necessary to compare the body fat percentage of obese animals after drug administration. The difficulty in measuring animals differs from that in humans. Firstly, animals move around unpredictably, making measurement difficult. Secondly, some animals are small, and measurements at different stages before, during, and after drug administration may not show significant changes, requiring greater precision. Conventional methods often employ either anesthesia-assisted testing or restraint-fixation testing. Anesthesia can affect the physiological state of small animals, interfering with the experimental results of drug intervention. Long-term and repeated anesthesia may also lead to health damage in small animals, affecting the experimental process. Restraint-fixation testing methods induce strong stress responses in small animals, altering their physiological metabolic levels and causing errors in body fat measurement results and the assessment of drug intervention effects, making it difficult to meet the low-stress requirements for long-term, repeated testing. Summary of the Invention

[0004] The purpose of this invention is to provide a low-stress dual-modal body fat detection device suitable for drug intervention in obese small animal models, in order to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a low-stress dual-modal body fat detection device suitable for drug intervention in obese small animal models, comprising a detection platform component and a first limiting component. The first limiting component is slidably installed at the four diagonal corners of the top of the detection platform component, and the left and right ends of the top of the detection platform component are vertically slidably connected to the adjustment frame. A second limiting component is horizontally slidably mounted between the two sets of adjustment frames. The first limiting component includes a first slide, a first fastening bolt, a movable rope loop, and an elastic binding rope. The first fastening bolt is vertically threaded through one end of the top of the first slide, and the movable rope loop is fixedly installed at the top of the other end of the first slide. An elastic binding rope is tied to the upper end of the movable rope loop. The elastic binding rope can gently fix the limbs of the obese small animal model to be tested, avoiding excessive restraint that could cause stress in the small animal.

[0006] Furthermore, the detection platform component includes a base, a buffer seat, a body fat detection platform, a first guide rail, and a second guide rail. The top surface of the base has an installation groove, and the buffer seat is fixedly embedded inside the installation groove. The body fat detection platform is fixedly embedded in the middle of the top surface of the buffer seat. The first guide rail is horizontally embedded at each of the four opposite corners of the top of the buffer seat, and the second guide rail is horizontally embedded at both the left and right ends of the top extension direction of the buffer seat.

[0007] Furthermore, the second guide rail is symmetrically fixed on the left and right sides of the body fat detection platform to adjust the frame to move back and forth in the horizontal direction. The first guide rail is arranged in an X-shaped structure to adjust the relative distance between the first limiting component and the middle of the body fat detection platform in the horizontal direction.

[0008] Furthermore, the first slide block and the first guide rail are connected in a slotted, embedded sliding connection, and the bottom end of the first fastening bolt abuts against the top of the first guide rail to adjust the overall position of the first limiting component.

[0009] Furthermore, the adjustment frame includes a second slide, a second fastening bolt, a support column, and a third guide rail. One end of the second slide is threaded vertically through the second fastening bolt, and the top of the other end of the second slide is vertically fixedly connected to the support column, and the side of the support column is vertically fixedly installed with the third guide rail.

[0010] Furthermore, the second slide block and the second guide rail are connected by a slotted embedded sliding connection, and the bottom end of the second fastening bolt abuts against the second guide rail to lock and fix the horizontal position of the adjustment frame.

[0011] Furthermore, the second limiting component includes a dual-modal detection probe, a flexible pressure pad, a third slide, and a third fastening bolt. The bottom surface of the dual-modal detection probe is attached with a flexible pressure pad, and the two ends of the dual-modal detection probe are integrally provided with a third slide. The upper end of the third slide is horizontally installed with a third fastening bolt.

[0012] Furthermore, the bottom of the dual-modal detection probe adopts an arc-shaped structure, and the dual-modal detection probe is connected to the third guide rails of the left and right adjustment frames in a slotted embedded sliding connection using the third slide blocks at both ends. The bottom end of the third fastening bolt abuts against the third guide rail to lock the height position of the dual-modal detection probe. The dual-modal detection probe is electrically connected to an external data processing terminal. The soft pressure pad is made of medical-grade flexible silicone in one piece, which can disperse pressure when in contact with the small animal's body, avoiding discomfort and stress response caused by direct pressure from hard structures, while ensuring fit and stability of the dual-modal detection signal.

[0013] This invention provides a low-stress dual-modal body fat detection device suitable for drug intervention in small animal obesity models, which has the following beneficial effects: 1. The present invention, through the structural setting of the first limiting component, can, on the one hand, flexibly adjust the position of the four diagonal first limiting components according to the size of the obese model animals of different sizes, so as to adapt to the limb fixation needs of small animals of different sizes. On the other hand, the elastic binding rope can adapt to the small animal's small movements by its own elasticity, so as to limit the small animal's large-scale movements from affecting the detection, while avoiding the stress response caused by rigid tight restraint.

[0014] 2. This invention, through the structural design of the adjustment frame and the second limiting component, allows for two main advantages. First, the horizontal position of the dual-modal detection probe can be flexibly adjusted according to the length of the small animal's body, while the vertical height of the probe can be adjusted according to the animal's body height, adapting to the detection needs of obese animal models of different weights and body types. Second, the soft pressure pad at the bottom of the dual-modal detection probe can disperse pressure when it fits the animal's body, preventing the hard probe from directly pressing on the animal's body and causing discomfort and stress. This also ensures the fit between the probe and the body, stabilizes the detection signal, and improves detection accuracy. Furthermore, the number of adjustment frames and the second limiting component can be increased or decreased as needed to meet different usage requirements.

[0015] 3. This invention, through the structural design of the detection stage components, allows for the integration of a micro-bioelectrical impedance and high-frequency ultrasound dual-modal detection component with a noise-reducing acquisition circuit. It acquires standardized fat thickness information at specific sites via ultrasound and combines this with bioelectrical impedance signal fusion to calculate body fat indices. The entire system operates without an X-ray radiation source, circumventing radiation safety regulations. It can accurately identify minute fluctuations in body fat before and after drug intervention in obese small animals, solving the problem of unstable detection of thin fat layers and subtle changes in body fat in small experimental animals. Furthermore, the buffer seat cushions vibrations caused by the animal's struggles, preventing interference with the body fat detection signal and further improving the stability of the results. Compared to existing technologies, this device eliminates the need for anesthesia in small animals, achieving stable detection through gentle restraint. This significantly reduces stress during detection, avoiding interference from anesthesia or strong restraint on the animal's physiological state and drug intervention results, and meeting the low-stress requirements for long-term, repeated testing. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the main body axis of the low-stress dual-modal body fat detection device suitable for drug intervention in small obese animal models according to the present invention; Figure 2 This is a schematic diagram of the detection platform component of a low-stress dual-modal body fat detection device suitable for drug intervention in obese small animals according to the present invention; Figure 3This is a three-dimensional structural diagram of the first limiting component of a low-stress dual-modal body fat detection device suitable for drug intervention in obese small animals according to the present invention; Figure 4 This is a schematic diagram of the three-dimensional structure of the adjustment frame of a low-stress dual-modal body fat detection device suitable for drug intervention in small obese animal models according to the present invention; Figure 5 This is a three-dimensional structural diagram of the second limiting component of a low-stress dual-modal body fat detection device suitable for drug intervention in obese small animals according to the present invention.

[0017] In the diagram: 1. Testing platform component; 101. Base; 102. Buffer seat; 103. Body fat testing platform; 104. First guide rail; 105. Second guide rail; 2. First limiting component; 201. First slide; 202. First fastening bolt; 203. Movable rope loop; 204. Elastic binding rope; 3. Adjusting frame; 301. Second slide; 302. Second fastening bolt; 303. Support column; 304. Third guide rail; 4. Second limiting component; 401. Dual-modal detection probe; 402. Soft pressure pad; 403. Third slide; 404. Third fastening bolt. Detailed Implementation

[0018] The embodiments of the present invention will be described in further detail below with reference to the accompanying drawings and examples. The following examples are for illustrative purposes only and should not be construed as limiting the scope of the invention.

[0019] like Figures 1 to 5As shown, a low-stress dual-modal body fat detection device suitable for drug intervention in obese small animals includes a detection platform component 1 and a first limiting component 2. The first limiting component 2 is slidably installed at the four diagonal corners of the top of the detection platform component 1, and the left and right ends of the top of the detection platform component 1 are vertically slidably connected to the adjustment frame 3. A second limiting component 4 is horizontally slidably mounted between the two sets of adjustment frames 3. The first limiting component 2 includes a first slide 201, a first fastening bolt 202, a movable rope ring 203, and an elastic binding rope 204. The first fastening bolt 202 is vertically threaded through one end of the top of the first slide 201, and the movable rope ring 203 is fixedly installed at the top of the other end of the first slide 201. The upper end of the movable rope ring 203 is tied with an elastic binding rope 204. The elastic binding rope 204 can gently fix the limbs of the obese small animal to be tested, avoiding excessive restraint that may cause stress response in the small animal.The first slide block 201 and the first guide rail 104 are connected by a slotted embedded sliding connection. The bottom end of the first fastening bolt 202 abuts against the top of the first guide rail 104 to adjust the overall position of the first limiting member 2. The detection table member 1 includes a base 101, a buffer seat 102, a body fat detection table 103, a first guide rail 104, and a second guide rail 105. The top surface of the base 101 has an installation groove, and the buffer seat 102 is fixedly embedded in the installation groove. The body fat detection table 103 is fixedly embedded in the middle of the top surface of the buffer seat 102. The four diagonal points of the top of the buffer seat 102 are all horizontal. The first guide rail 104 is embedded in the buffer seat 102, and the left and right ends of the top extension direction of the buffer seat 102 are horizontally embedded with the second guide rail 105. The second guide rail 105 is symmetrically fixed on the left and right sides of the body fat detection platform 103 for adjusting the frame 3 to move back and forth in the horizontal direction. The first guide rail 104 is arranged in an X-shape to adjust the relative distance between the first limiting member 2 and the middle of the body fat detection platform 103 in the horizontal direction. In use, the position can be adjusted by sliding the first slide 201 along the first guide rail 104 to adapt to the limbs of obese model animals of different body sizes. Once the desired position is achieved, tightening the first fastening bolt 202 will lock the position of the first limiting component 2. The operator then only needs to gently restrain the animal's limbs with the elastic binding rope 204. The elastic binding rope 204 can cushion small movements of the animal with its own elasticity, limiting large struggles while avoiding discomfort caused by strong restraint and reducing stress response. After adjusting the first limiting component 2, the operator can drive the second slide block 301 to slide along the second guide rail 105 to adjust the horizontal position of the adjusting frame 3 according to the length of the animal to be tested. Once in position, tightening the second fastening bolt 302 will lock the adjustment. The frame 3 is then used to adjust the height of the dual-modal detection probe 401 by sliding it vertically along the third guide rail 304 according to the height of the small animal's body. This allows it to adapt to obese model animals of different weights and body types. Once in place, tightening the third fastening bolt 404 locks the dual-modal detection probe 401 in place. At this time, the soft pressure pad 402 fits against the small animal's body, and the dual-modal detection can be started. The dual-modal detection probe 401 transmits the collected detection signals to an external data processing terminal, which can then calculate and output the body fat data. The entire detection process does not require anesthesia and stable detection can be completed simply by gentle positioning.

[0020] like Figures 1 to 5As shown, the adjustment frame 3 includes a second slide block 301, a second fastening bolt 302, a support column 303, and a third guide rail 304. One end of the second slide block 301 is vertically threaded through the second fastening bolt 302, and the top of the other end of the second slide block 301 is vertically fixedly connected to the support column 303. The side of the support column 303 is vertically fixedly mounted with the third guide rail 304. The second slide block 301 and the second guide rail 105 are connected by a slotted embedded sliding connection. The bottom end of the second fastening bolt 302 abuts against the second guide rail 105 to lock and fix the adjustment frame 3 in a horizontal position. The second limiting component 4 includes a dual-modal detection probe 401 and a flexible pressure pad. 402, third slide 403 and third fastening bolt 404, the bottom surface of the dual-modal detection probe 401 is attached with a flexible pressure pad 402, and the two ends of the dual-modal detection probe 401 are integrally provided with third slides 403, and the upper end of the third slide 403 is horizontally installed with a third fastening bolt 404. The bottom of the dual-modal detection probe 401 adopts an arc-shaped structure, and the dual-modal detection probe 401 is slidably connected to the third guide rails 304 of the left and right adjustment frames 3 by the three slides 403 at both ends in a slotted embedded manner. The bottom end of the third fastening bolt 404 abuts against the third guide rail 304 to realize the dual-modal detection probe 401. 01. Height-based locking: The dual-modal detection probe 401 is electrically connected to an external data processing terminal. The soft pressure pad 402 is made of medical-grade flexible silicone and is integrally molded. When in contact with the small animal's body, it can disperse pressure, avoiding discomfort and stress caused by direct pressure from hard structures, while ensuring a good fit and the stability of the dual-modal detection signal. During use, the horizontal position of the adjustment frame 3 can be changed by sliding the second slide 301 along the second guide rail 105, thereby adjusting the front and rear position of the dual-modal detection probe 401 according to the body length of the small animal to be tested. After the position is adjusted, tightening the second fastening bolt 302 will lock the probe in place. To prevent displacement of the adjustment frame 3 during the detection process; after adjusting the horizontal position, the dual-modal detection probe 401 can slide vertically along the third guide rail 304 through the third slides 403 at both ends, so that the vertical height of the probe can be adjusted according to the body height of the small animal, adapting to the detection needs of obese model small animals of different weights. After it is in place, tighten the third fastening bolt 404 to lock the probe position. At this time, the soft pressure pad 402 fits against the surface of the small animal's body. The flexible silicone material can disperse the pressure applied by the probe, so that the small animal will not be uncomfortable or stressed due to direct pressure from the hard probe, and the fit between the probe and the body can be guaranteed, ensuring stable output of the detection signal.

[0021] In summary, as Figures 1 to 5As shown, this low-stress bimodal body fat detection device, suitable for drug intervention in obese small animals, is used as follows: First, the obese small animal to be tested is placed on the top surface of the body fat detection platform 103. The positions of the four diagonal first limiting members 2 are adjusted according to the animal's body shape, so that the first slide 201 slides along the first guide rail 104 to the appropriate position. Then, the first fastening bolt 202 is tightened to lock the position of the first limiting member 2. Subsequently, the animal's limbs are gently fixed with elastic binding ropes 204. Next, the horizontal position of the adjusting frame 3 is adjusted according to the animal's body length, so that the second slide 301 slides along the second guide rail 105 to the corresponding position. The second fastening bolt 302 is tightened to lock the position of the adjusting frame 3. Finally, the vertical height of the second limiting member 4 is adjusted according to the animal's body height, so that the first sliding member 201 slides along the first guide rail 105 to the appropriate position. The three-slide seat 403 slides along the third guide rail 304 to the corresponding position, and the third fastening bolt 404 is tightened to lock the position of the dual-modal detection probe 401, so that the soft pressure pad 402 fits against the surface of the small animal's body, and the dual-modal detection can be started. During the detection process, the dual-modal detection component integrated inside the body fat detection stage 103 works with the dual-modal detection probe 401 above to synchronously acquire detection data. The data is transmitted to the external data processing terminal to complete the fusion calculation of body fat index and obtain the body fat detection results of the small animal. The entire detection process does not require anesthesia of the small animal, nor does it require rigid restraint, which can minimize the stress response of the small animal and avoid interference with the results of drug intervention experiments. It can meet the low-stress detection needs of repeated detections during long-term drug intervention.

[0022] The embodiments of the present invention are given for illustrative and descriptive purposes only, and are not intended to be exhaustive or to limit the invention to the forms disclosed. Many modifications and variations will be apparent to those skilled in the art. The embodiments were chosen and described in order to better illustrate the principles and practical application of the invention, and to enable those skilled in the art to understand the invention and to design various embodiments with various modifications suitable for a particular purpose.

Claims

1. A low-stress dual-modal body fat detection device suitable for drug intervention in obese small animals, comprising a detection stage component (1) and a first limiting component (2), characterized in that: The top of the testing platform component (1) is slidably installed with a first limiting component (2) at each of the four opposite corners. The top left and right ends of the testing platform component (1) are vertically slidably connected with an adjustment frame (3). A second limiting component (4) is horizontally slidably mounted between the two sets of adjustment frames (3). The first limiting component (2) includes a first slide (201), a first fastening bolt (202), a movable rope ring (203), and an elastic binding rope (204). The first fastening bolt (202) is vertically threaded through one end of the top of the first slide (201). The movable rope ring (203) is fixedly installed at the top of the other end of the first slide (201). An elastic binding rope (204) is tied to the upper end of the movable rope ring (203). The elastic binding rope (204) can be used to gently fix the limbs of the obese model animal to be tested, avoiding excessive restraint that could cause stress in the animal.

2. The low-stress dual-modal body fat detection device suitable for drug intervention in obese small animals according to claim 1, characterized in that, The testing platform component (1) includes a base (101), a buffer seat (102), a body fat testing platform (103), a first guide rail (104), and a second guide rail (105). The top surface of the base (101) is provided with an installation groove, and the buffer seat (102) is fixedly embedded in the installation groove. The body fat testing platform (103) is fixedly embedded in the middle of the top surface of the buffer seat (102). The first guide rail (104) is horizontally embedded at the four opposite corners of the top of the buffer seat (102), and the second guide rail (105) is horizontally embedded at both ends of the left and right ends of the top extension direction of the buffer seat (102).

3. The low-stress dual-modal body fat detection device suitable for drug intervention in obese small animals according to claim 2, characterized in that, The second guide rail (105) is symmetrically fixed on the left and right sides of the body fat detection platform (103) for adjusting the frame (3) to move back and forth in the horizontal direction. The first guide rail (104) is arranged in an X-shaped structure for adjusting the relative distance between the first limiting member (2) and the body fat detection platform (103) in the horizontal direction.

4. The low-stress dual-modal body fat detection device suitable for drug intervention in obese small animals according to claim 2, characterized in that, The first slide block (201) and the first guide rail (104) are connected by a slotted embedded sliding connection. The bottom end of the first fastening bolt (202) abuts against the top of the first guide rail (104) to adjust the overall position of the first limiting member (2).

5. The low-stress dual-modal body fat detection device suitable for drug intervention in obese small animals according to claim 2, characterized in that, The adjustment frame (3) includes a second slide (301), a second fastening bolt (302), a support column (303), and a third guide rail (304). One end of the second slide (301) is vertically threaded through the second fastening bolt (302), and the other end of the second slide (301) is vertically fixedly connected to the top of the support column (303), and the third guide rail (304) is vertically fixedly installed on the side of the support column (303).

6. The low-stress dual-modal body fat detection device suitable for drug intervention in obese small animals according to claim 5, characterized in that, The second slide (301) and the second guide rail (105) are connected by a slotted embedded sliding connection, and the bottom end of the second fastening bolt (302) abuts against the second guide rail (105) to lock and fix the horizontal position of the adjustment frame (3).

7. The low-stress dual-modal body fat detection device suitable for drug intervention in obese small animals according to claim 5, characterized in that, The second limiting component (4) includes a dual-modal detection probe (401), a flexible pressure pad (402), a third slide (403), and a third fastening bolt (404). The bottom surface of the dual-modal detection probe (401) is attached with a flexible pressure pad (402), and the two ends of the dual-modal detection probe (401) are integrally provided with a third slide (403). The upper end of the third slide (403) is horizontally installed with a third fastening bolt (404).

8. The low-stress dual-modal body fat detection device suitable for drug intervention in obese small animals according to claim 7, characterized in that, The bottom of the dual-modal detection probe (401) is set with an arc-shaped structure, and the dual-modal detection probe (401) is connected to the third guide rail (304) of the left and right adjustment brackets (3) by the third slides (403) at both ends in a slotted embedded sliding connection. Moreover, the bottom end of the third fastening bolt (404) abuts against the third guide rail (304) to lock the height position of the dual-modal detection probe (401).

9. A low-stress dual-modal body fat detection device suitable for drug intervention in obese small animals, as described in claim 8, is characterized in that... The dual-modal detection probe (401) is electrically connected to an external data processing terminal. The soft pressure pad (402) is made of medical-grade flexible silicone and can disperse pressure when in contact with the body of a small animal.

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