Preparation method of traditional Chinese medicine ointment for treating diabetic foot
Patent Information
- Application Number
- CN202410154185.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-02-02
- Publication Date
- 2026-10-20
AI Technical Summary
[0002]糖尿病足(DF)是糖尿病的主要并发症之一，也是患者致残的主要原因；这一病症的治疗难度大，周期长，截肢率、致死率、复发率高，给患者和社会带来沉重负担；尽管中西医药物治疗、局部清创和中西药外科换药对部分患者有一定疗效，血管重建术和血管腔内介入技术也降低了截肢率，但糖尿病足的治疗仍是临床难题；因此，积极治疗糖尿病足溃疡至关重要；
[0027]本发明通过采用煅石膏粉末、臭牡丹叶和芙蓉叶作为治疗糖尿病足的主要原料，能带来多重益处；煅石膏粉末能收敛创口，促进肉芽组织生长，加速愈合过程；臭牡丹叶则发挥其清热解毒、消肿止痛的作用，减轻炎症反应和患者疼痛；芙蓉叶抗菌抗炎，有效预防感染，并促进细胞再生；这三者结合，不仅有助于溃疡面的快速愈合，还能显著缓解患者的疼痛感，降低并发症风险；这种治疗方法简便易行，取材方便，成本低廉，适合广大患者使用；因此，采用煅石膏粉末、臭牡丹叶和芙蓉叶作为治疗糖尿病足的原料，无疑为患者提供了一种安全、有效的治疗选择。
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Abstract
Description
Technical Field
[0001] This invention belongs to the field of traditional Chinese medicine preparation technology, specifically a method for preparing a traditional Chinese medicine ointment for the treatment of diabetic foot. Background Technology
[0002] Diabetic foot (DF) is one of the major complications of diabetes and a leading cause of disability. Treatment of this condition is challenging, lengthy, and involves high rates of amputation, mortality, and recurrence, placing a heavy burden on patients and society. Although traditional Chinese and Western medicine treatments, local debridement, and surgical dressing changes using both traditional Chinese and Western medicine have shown some efficacy in some patients, and vascular reconstruction and endovascular interventional techniques have reduced amputation rates, the treatment of diabetic foot remains a clinical challenge. Therefore, actively treating diabetic foot ulcers is crucial.
[0003] The pathogenesis of diabetic foot is complex and involves multiple factors; prevention and treatment of single links or targets are difficult, which is one of the reasons why modern medicine has not found ideal drugs. Traditional Chinese medicine (TCM) has unique advantages in the prevention and treatment of diabetic foot ulcers, especially in external application. TCM external treatments are simple to operate, easy to obtain materials, inexpensive, and have a variety of dosage forms to choose from, which can be flexibly selected according to the condition of the ulcer. Extracting the core TCM pathogenesis of diabetic foot and developing ideal TCM external treatment preparations are key to improving the overall level of external treatment for diabetic foot. TCM compound external preparations achieve comprehensive effects through multiple pathways and levels of action, corresponding to the complex mechanism of diabetic foot development, demonstrating the advantages of the holistic concept of TCM. Currently, Western medicine treatment is difficult and expensive, while TCM external application has unique effects. Summary of the Invention
[0004] The purpose of this invention is to provide a method for preparing a traditional Chinese medicine ointment for the treatment of diabetic foot, so as to solve the problems mentioned in the background art.
[0005] To achieve the above objectives, the present invention provides the following technical solution: a method for preparing a traditional Chinese medicine ointment for the treatment of diabetic foot, the preparation method comprising the following steps:
[0006] S1, Prepare the medicinal materials; Prepare the required medicinal materials in advance according to their material properties and quantities, and then arrange them in order according to the required processing steps;
[0007] S2, Ointment preparation: Take 30 parts of calcined gypsum powder, 10 parts of pig bile, 5 parts of lanolin, 1 part of polyethylene glycol, 5 parts of glyceryl stearate, and 5 parts of propylene glycol, and use a special technique with a thin wooden stick to quickly stir them together.
[0008] S3, Knead and Dry: Use both hands to knead the mixed ointment into a one-pound ball, then place it in a cool, ventilated place to dry for six months, taking precautions against dust.
[0009] S4, calcination to remove toxins; place the dried spherical calcined gypsum on a charcoal fire and calcinate again. After being fully calcined, place the spherical calcined gypsum in a cool place for one month to solidify.
[0010] S5, preliminary proportioning: Take spherical calcined gypsum, stinking peony leaves and hibiscus leaves in a 1:1:1 ratio, put them together and grind them into powder.
[0011] S6, Secondary formulation: Take 8 parts beeswax and 2 parts forsythia, grind them into powder, and then mix them with the finished powder in S5;
[0012] S7, Screening and Storage: A 100-mesh sieve is used for screening to remove large particles of medicinal materials, which are then sealed and stored in a ceramic jar for later use.
[0013] Preferably, the formulation involved in the preparation method of the traditional Chinese medicine ointment is made by combining effective ingredients and matrix excipients. The effective ingredients are made from the following raw materials in parts by weight: 30 parts calcined gypsum powder, 10 parts pig bile, 5 parts peony leaf and 5 parts hibiscus leaf; the matrix excipients are made from the following raw materials in parts by weight: 5 parts lanolin, 1 part polyethylene glycol, 5 parts glyceryl stearate, 5 parts propylene glycol, 8 parts beeswax and 2 parts forsythia.
[0014] Preferably, the special technique in S2 is as follows: hold the thin stick tightly with both hands, left hand on top and right hand on the bottom, first rotate it clockwise 10 times, then rotate it counterclockwise 10 times, then pause for 30 seconds, and continue to repeat the cycle until no large clumps of dry powder appear.
[0015] Preferably, the screening step in S7 is as follows:
[0016] Step 1, Prepare the sieve: Select a 100-mesh sieve and ensure that its aperture size meets the requirements;
[0017] Step 2, Clean the screen: Clean the screen thoroughly to ensure it is free of foreign objects, and then dry it.
[0018] Step 3, Place the medicinal materials: Place the ground medicinal materials from S5 and S6 together on the sieve;
[0019] Step 4, sieving operation: Gently tap the sieve by hand or with tools to allow the medicinal materials to pass through the sieve holes;
[0020] Step 5, check the screening results: Check the screened medicinal materials to ensure they meet the requirements.
[0021] Preferably, the method of use involved in the preparation method of this traditional Chinese medicine ointment is as follows:
[0022] A1. Take appropriate amount of powder; observe the size of the wound ulcer, and pour an appropriate amount of powder into a bowl for later use;
[0023] A2, Prepare before use: Add appropriate camphor powder to it, then add an appropriate amount of tung oil and mix it into a thin paste;
[0024] A3. Apply medication with gauze; Take a clean piece of medical gauze, spread the medication evenly on the gauze, ensuring the area is the same size as the wound, and cover the wound.
[0025] A4. Apply gauze; use breathable elastic bandages for wrapping, ensuring the tightness is appropriate.
[0026] The beneficial effects of this invention are as follows:
[0027] This invention utilizes calcined gypsum powder, peony leaf, and hibiscus leaf as the main raw materials for treating diabetic foot, offering multiple benefits. Calcined gypsum powder can astringe wounds, promote granulation tissue growth, and accelerate the healing process. Peony leaf exerts its effects of clearing heat and detoxifying, reducing swelling and relieving pain, thus alleviating inflammatory reactions and patient pain. Hibiscus leaf has antibacterial and anti-inflammatory properties, effectively preventing infection and promoting cell regeneration. The combination of these three ingredients not only helps the ulcer heal quickly but also significantly alleviates patient pain and reduces the risk of complications. This treatment method is simple, easy to implement, uses readily available materials, and is inexpensive, making it suitable for a wide range of patients. Therefore, using calcined gypsum powder, peony leaf, and hibiscus leaf as raw materials for treating diabetic foot undoubtedly provides patients with a safe and effective treatment option. Attached Figure Description
[0028] Figure 1 This is a flowchart illustrating the preparation method of the herbal ointment of the present invention;
[0029] Figure 2 This is a flowchart of the screening steps of the present invention;
[0030] Figure 3 This is a flowchart of the method of using the present invention. Detailed Implementation
[0031] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.
[0032] like Figures 1 to 3 As shown, this embodiment of the invention provides a method for preparing a traditional Chinese medicine ointment for the treatment of diabetic foot. The preparation method of the ointment includes the following steps:
[0033] S1, Prepare the medicinal materials; Prepare the required medicinal materials in advance according to their material properties and quantities, and then arrange them in order according to the required processing steps;
[0034] S2, Ointment preparation: Take 30 parts of calcined gypsum powder, 10 parts of pig bile, 5 parts of lanolin, 1 part of polyethylene glycol, 5 parts of glyceryl stearate, and 5 parts of propylene glycol, and use a special technique with a thin wooden stick to quickly stir them together.
[0035] S3, Knead and Dry: Use both hands to knead the mixed ointment into a one-pound ball, then place it in a cool, ventilated place to dry for six months, taking precautions against dust.
[0036] S4, calcination to remove toxins; place the dried spherical calcined gypsum on a charcoal fire and calcinate again. After being fully calcined, place the spherical calcined gypsum in a cool place for one month to solidify.
[0037] S5, preliminary proportioning: Take spherical calcined gypsum, stinking peony leaves and hibiscus leaves in a 1:1:1 ratio, put them together and grind them into powder.
[0038] S6, Secondary formulation: Take 8 parts beeswax and 2 parts forsythia, grind them into powder, and then mix them with the finished powder in S5;
[0039] S7, Screening and Storage: A 100-mesh sieve is used for screening to remove large particles of medicinal materials, which are then sealed and stored in a ceramic jar for later use.
[0040] The formulation involved in the preparation method of this traditional Chinese medicine ointment is composed of active ingredients and matrix excipients. The active ingredients are made from the following raw materials in parts by weight: 30 parts calcined gypsum powder, 10 parts pig bile, 5 parts peony leaf and 5 parts hibiscus leaf. The matrix excipients are made from the following raw materials in parts by weight: 5 parts lanolin, 1 part polyethylene glycol, 5 parts glyceryl stearate, 5 parts propylene glycol, 8 parts beeswax and 2 parts forsythia.
[0041] The special technique in S2 is as follows: hold the thin stick tightly with both hands, left hand on top and right hand on the bottom, first rotate it clockwise 10 times, then rotate it counterclockwise 10 times, then pause for 30 seconds, and continue to repeat the cycle until no large clumps of dry powder appear.
[0042] The screening step in S7 is as follows:
[0043] Step 1, Prepare the sieve: Select a 100-mesh sieve and ensure that its aperture size meets the requirements;
[0044] Step 2, Clean the screen: Clean the screen thoroughly to ensure it is free of foreign objects, and then dry it.
[0045] Step 3, Place the medicinal materials: Place the ground medicinal materials from S5 and S6 together on the sieve;
[0046] Step 4, sieving operation: Gently tap the sieve by hand or with tools to allow the medicinal materials to pass through the sieve holes;
[0047] Step 5, check the screening results: Check the screened medicinal materials to ensure they meet the requirements.
[0048] The method of use involved in the preparation of this traditional Chinese medicine ointment is as follows:
[0049] A1. Take appropriate amount of powder; observe the size of the wound ulcer, and pour an appropriate amount of powder into a bowl for later use;
[0050] A2, Prepare before use: Add appropriate camphor powder to it, then add an appropriate amount of tung oil and mix it into a thin paste;
[0051] A3. Apply medication with gauze; Take a clean piece of medical gauze, spread the medication evenly on the gauze, ensuring the area is the same size as the wound, and cover the wound.
[0052] A4. Apply gauze; use breathable elastic bandages for wrapping, ensuring the tightness is appropriate.
[0053] Change the dressing once a day; if the patient has pain at rest, the pain will disappear that same evening; depending on the size of the sore, it will heal in about 30-45 days.
[0054] Typical case:
[0055] Case 1: Jia XX, male, 52 years old, from Baiji Town, Bengbu, Anhui Province, suffered from diabetic foot. After treatment at Huaiwei Hospital, the condition relapsed. Later, through the introduction of relatives and friends, Jia Tianpu took the high-speed rail to my clinic for treatment. He was treated in the manner described above. After a month, the skin ulcers were almost completely gone, and after more than half a month, the disease was cured. Now, more than 3 years have passed and there has been no recurrence.
[0056] Case 2: Ms. Wang XX, 29 years old, from Jinzhai County, Lu'an City, Anhui Province, suffered from diabetic foot. Ms. Wang XX came to my clinic for treatment through the introduction of relatives and friends. After a month of treatment, the ulcers were almost completely healed.
[0057] Case 3: Luo XX, male, 36 years old, from Shizong County, Yunnan Province, suffered from diabetic foot. He had taken various Chinese and Western medicines and visited three hospitals. After a month of treatment with me, the ulcers were almost completely healed; follow-up visits showed no recurrence.
[0058] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.
[0059] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.
Claims
1. A method for preparing a traditional Chinese medicine ointment for the treatment of diabetic foot, characterized in that: The preparation method of this ointment includes the following steps: S1, Prepare the medicinal materials; Prepare the required medicinal materials in advance according to their material properties and quantities, and then arrange them in order according to the required processing steps; S2, Ointment preparation: Take 30 parts of calcined gypsum powder, 10 parts of pig bile, 5 parts of lanolin, 1 part of polyethylene glycol, 5 parts of glyceryl stearate, and 5 parts of propylene glycol, and use a special technique with a thin wooden stick to quickly stir them together. S3, Knead and Dry: Use both hands to knead the mixed ointment into a one-pound ball, then place it in a cool, ventilated place to dry for six months, taking precautions against dust. S4, calcination to remove toxins; place the dried spherical calcined gypsum on a charcoal fire and calcinate again. After being fully calcined, place the spherical calcined gypsum in a cool place for one month to solidify. S5, preliminary proportioning: Take spherical calcined gypsum, stinking peony leaves and hibiscus leaves in a 1:1:1 ratio, put them together and grind them into powder. S6, Secondary formulation: Take 8 parts beeswax and 2 parts forsythia, grind them into powder, and then mix them with the finished powder in S5; S7, Screening and Storage: A 100-mesh sieve is used for screening to remove large particles of medicinal materials, which are then sealed and stored in a ceramic jar for later use.
2. The method for preparing a traditional Chinese medicine ointment for the treatment of diabetic foot according to claim 1, characterized in that: The formulation involved in the preparation method of this traditional Chinese medicine ointment is composed of active ingredients and matrix excipients. The active ingredients are made from the following raw materials in parts by weight: 30 parts calcined gypsum powder, 10 parts pig bile, 5 parts peony leaf and 5 parts hibiscus leaf; the matrix excipients are made from the following raw materials in parts by weight: 5 parts lanolin, 1 part polyethylene glycol, 5 parts glyceryl stearate, 5 parts propylene glycol, 8 parts beeswax and 2 parts forsythia.
3. The method for preparing a traditional Chinese medicine ointment for the treatment of diabetic foot according to claim 1, characterized in that: The special technique in S2 is as follows: Hold the thin stick firmly with both hands, left hand on top and right hand on the bottom, first rotate it clockwise 10 times, then rotate it counterclockwise 10 times, then pause for 30 seconds, and continue to repeat the cycle until no large clumps of dry powder appear.
4. The method for preparing a traditional Chinese medicine ointment for the treatment of diabetic foot according to claim 1, characterized in that: The screening step in S7 is as follows: Step 1, Prepare the sieve: Select a 100-mesh sieve and ensure that its aperture size meets the requirements; Step 2, Clean the screen: Clean the screen thoroughly to ensure it is free of foreign objects, and then dry it. Step 3, Place the medicinal materials: Place the ground medicinal materials from S5 and S6 together on the sieve; Step 4, sieving operation: Gently tap the sieve by hand or with tools to allow the medicinal materials to pass through the sieve holes; Step 5, check the screening results: Check the screened medicinal materials to ensure they meet the requirements.
5. The method for preparing a traditional Chinese medicine ointment for the treatment of diabetic foot according to claim 1, characterized in that: The method of using this traditional Chinese medicine ointment preparation involves the following: A1. Take appropriate amount of powder; observe the size of the wound ulcer, and pour an appropriate amount of powder into a bowl for later use; A2, prepare before use; add an appropriate amount of camphor powder. Add an appropriate amount of tung oil and mix it into a thin paste; A3. Apply medication with gauze; Take a clean piece of medical gauze, spread the medication evenly on the gauze, ensuring the area is the same size as the wound, and cover the wound. A4. Apply gauze; use breathable elastic bandages for wrapping, ensuring the tightness is appropriate.