A multimodal neuromodulation and lymphatic drainage coordination system based on electroencephalogram feedback

Abstract

This application discloses a multimodal neuromodulation and lymphatic drainage synergistic system based on EEG feedback, relating to the fields of neuromodulation and medical device technology. In this system, a head-mounted multimodal stimulation unit applies light, sound, and somatosensory stimulation to the subject; a neck mechanical stimulation unit applies periodic mechanical pressure to the subject; an EEG monitoring unit collects EEG signals and extracts steady-state evoked potential characteristics of the gamma oscillation band; and a central control unit adjusts the output parameters of each module in the head-mounted multimodal stimulation unit and the neck mechanical stimulation unit according to the steady-state evoked potential characteristics, synchronously adjusting the output intensity of each module in the head-mounted multimodal stimulation unit during the application and intervals of mechanical pressure by the neck mechanical stimulation unit. This application addresses the difficulty of synergistically driving intracerebral multimodal neuromodulation and extracerebral lymphatic drainage within the same system, and the lack of a dynamic synergistic regulation mechanism based on real-time EEG feedback in intracerebral multimodal neuromodulation.

Description

Technical Field

[0001] This application relates to the fields of neuromodulation and medical device technology, and in particular to a multimodal neuromodulation and lymphatic drainage synergistic system based on EEG feedback. Background Technology

[0002] Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by neuronal loss, brain atrophy, and progressive cognitive decline. Gamma oscillations, voltage potentials generated by synchronized neuronal activity, are crucial for sensory processing, cognitive function, and memory consolidation, and are severely disrupted in AD patients. Studies have shown that sensory stimulation can induce synchronization of gamma oscillations in the brain. Furthermore, the brain's lymphoid system drains cerebrospinal fluid (CSF) to the cervical lymph nodes via superficial cervical lymphatic vessels; non-invasive mechanical stimulation can increase the outflow of CSF.

[0003] Currently, several multimodal stimulation protocols for AD intervention have been proposed. Some protocols focus on intracranial neuromodulation, attempting to restore intracranial gamma oscillation synchrony through one or more combinations of light, sound, or somatosensory stimulation. Other protocols focus on extracerebral lymphatic drainage, attempting to enhance cerebrospinal fluid outflow and metabolic waste removal through mechanical or electrical stimulation of the neck region. However, these two types of protocols are currently independent in existing technologies; intracranial neuromodulation and extracerebral lymphatic drainage are implemented in different systems and operate independently, failing to form a complete "intracranial production-extracerebral drainage" pathway.

[0004] Among existing multimodal neuromodulation schemes in the brain, although some schemes attempt to combine light stimulation, sound stimulation or somatosensory stimulation, there is a lack of dynamic collaborative regulation mechanism based on real-time EEG feedback between the various modalities. They often output independently with fixed parameters, making it difficult to adaptively link and optimize the multimodal parameters according to the individual's real-time EEG response state, resulting in limited synchronization effect of multi-pathway gamma oscillations.

[0005] Therefore, how to achieve synergistic driving of intracranial multimodal neuromodulation and extracranial lymphatic drainage in a single system, and how to achieve dynamic synergistic regulation based on real-time EEG feedback in intracranial multimodal neuromodulation, are urgent problems to be solved in the field of neuromodulation and AD intervention. Summary of the Invention

[0006] The purpose of this application is to provide a multimodal neuromodulation and lymphatic drainage synergy system based on EEG feedback, in order to solve the problems that it is difficult to coordinate intrabrain multimodal neuromodulation and extrabrain lymphatic drainage in the same system, and the lack of a dynamic synergistic regulation mechanism based on real-time EEG feedback in intrabrain multimodal neuromodulation.

[0007] To achieve the above objectives, this application provides the following solution.

[0008] In a first aspect, this application provides a multimodal neuromodulation and lymphatic drainage synergy system based on EEG feedback, comprising: a head-mounted multimodal stimulation unit, a neck mechanical stimulation unit, an EEG monitoring unit, and a central control unit; the head-mounted multimodal stimulation unit, the neck mechanical stimulation unit, and the EEG monitoring unit are all connected to the central control unit; the head-mounted multimodal stimulation unit includes a visual stimulation module, an auditory stimulation module, and a somatosensory stimulation module; The visual stimulation module is used to apply periodic light stimulation to the subject's eyes; The auditory stimulation module is used to apply periodic sound stimulation to the subject's ears; The somatosensory stimulation module is used to apply periodic somatosensory stimulation to the subject's head; The neck mechanical stimulation unit is used to apply periodic mechanical pressure to the superficial lymphatic vessels of the subject's neck. The EEG monitoring unit is used to collect the subject's EEG signals and extract the steady-state evoked potential features of the γ oscillation frequency band; the steady-state evoked potential features include the power spectral density and / or phase lock value of the 40Hz±2Hz frequency band; The central control unit is used for: Based on the characteristics of steady-state evoked potentials, adjust the output parameters of the visual stimulation module, the auditory stimulation module, the somatosensory stimulation module, and the neck mechanical stimulation unit; During the period and interval of applying mechanical pressure to the neck mechanical stimulation unit, the output intensity of the output parameters of the visual stimulation module, the auditory stimulation module and the somatosensory stimulation module is adjusted synchronously.

[0009] In one embodiment, the somatosensory stimulation module includes a first somatosensory stimulation unit and a second somatosensory stimulation unit; the first somatosensory stimulation unit is configured to stimulate at least one acupoint on the subject's head, and the second somatosensory stimulation unit is configured to stimulate at least one brain functional area on the subject's head.

[0010] In one embodiment, the output frequencies of the visual stimulation module, the auditory stimulation module, and the somatosensory stimulation module are all 30Hz-90Hz.

[0011] In one embodiment, the mechanical pressure applied by the neck mechanical stimulation unit ranges from 0.01 kgf to 0.08 kgf, the pressing frequency is once every 1.5 seconds to 3 seconds, and the duration of each application is 1.5 seconds to 2.5 seconds.

[0012] In one embodiment, the somatosensory stimulation module is a transcutaneous electrical stimulation module, and both the first somatosensory stimulation unit and the second somatosensory stimulation unit are electrodes; The output parameters of the electrode include a current output intensity range of 0.5mA-5mA, a pulse width range of 100μs-300μs, and a biphasic square wave waveform.

[0013] In one embodiment, the somatosensory stimulation module is a transcranial magnetic stimulation module, and both the first somatosensory stimulation unit and the second somatosensory stimulation unit are coils; The output parameters of the coil include a magnetic induction output intensity range of 0-20mT, a frequency range of 1Hz-100Hz, and a duty cycle range of 1%-50%.

[0014] Secondly, this application provides a multimodal neuromodulation and lymphatic drainage synergy system based on EEG feedback, comprising: a head-mounted multimodal stimulation unit, a neck mechanical stimulation unit, an EEG monitoring unit, and a central control unit; the head-mounted multimodal stimulation unit, the neck mechanical stimulation unit, and the EEG monitoring unit are all connected to the central control unit; the head-mounted multimodal stimulation unit includes a visual stimulation module and an auditory stimulation module; The visual stimulation module is used to apply periodic light stimulation to the subject's eyes; The auditory stimulation module is used to apply periodic sound stimulation to the subject's ears; The neck mechanical stimulation unit is used to apply periodic mechanical pressure to the superficial lymphatic vessels of the subject's neck. The EEG monitoring unit is used to collect the subject's EEG signals and extract the steady-state evoked potential features of the γ oscillation frequency band; the steady-state evoked potential features include the power spectral density and / or phase lock value of the 40Hz±2Hz frequency band; The central control unit is used for: Based on the characteristics of steady-state evoked potentials, adjust the output parameters of the visual stimulation module, the auditory stimulation module, and the neck mechanical stimulation unit; During the period and interval of applying mechanical pressure to the neck mechanical stimulation unit, the output intensity in the output parameters of the visual stimulation module and the auditory stimulation module is adjusted synchronously.

[0015] Thirdly, this application provides a multimodal neuromodulation and lymphatic drainage synergy system based on EEG feedback, comprising: a head-mounted multimodal stimulation unit, a neck mechanical stimulation unit, an EEG monitoring unit, and a central control unit; the head-mounted multimodal stimulation unit, the neck mechanical stimulation unit, and the EEG monitoring unit are all connected to the central control unit; the head-mounted multimodal stimulation unit includes a visual stimulation module and a somatosensory stimulation module; The visual stimulation module is used to apply periodic light stimulation to the subject's eyes; The somatosensory stimulation module is used to apply periodic somatosensory stimulation to the subject's head; The neck mechanical stimulation unit is used to apply periodic mechanical pressure to the superficial lymphatic vessels of the subject's neck. The EEG monitoring unit is used to collect the subject's EEG signals and extract the steady-state evoked potential features of the γ oscillation frequency band; the steady-state evoked potential features include the power spectral density and / or phase lock value of the 40Hz±2Hz frequency band; The central control unit is used for: Based on the characteristics of steady-state evoked potentials, adjust the output parameters of the visual stimulation module, the somatosensory stimulation module, and the neck mechanical stimulation unit; During the period and interval of applying mechanical pressure to the neck mechanical stimulation unit, the output intensity in the output parameters of the visual stimulation module and the somatosensory stimulation module is adjusted synchronously.

[0016] Fourthly, this application provides a multimodal neuromodulation and lymphatic drainage synergy system based on EEG feedback, comprising: a head-mounted multimodal stimulation unit, a neck mechanical stimulation unit, an EEG monitoring unit, and a central control unit; the head-mounted multimodal stimulation unit, the neck mechanical stimulation unit, and the EEG monitoring unit are all connected to the central control unit; the head-mounted multimodal stimulation unit includes an auditory stimulation module and a somatosensory stimulation module; The auditory stimulation module is used to apply periodic sound stimulation to the subject's ears; The somatosensory stimulation module is used to apply periodic somatosensory stimulation to the subject's head; The neck mechanical stimulation unit is used to apply periodic mechanical pressure to the superficial lymphatic vessels of the subject's neck. The EEG monitoring unit is used to collect the subject's EEG signals and extract the steady-state evoked potential features of the γ oscillation frequency band; the steady-state evoked potential features include the power spectral density and / or phase lock value of the 40Hz±2Hz frequency band; The central control unit is used for: Based on the characteristics of steady-state evoked potentials, adjust the output parameters of the auditory stimulation module, the somatosensory stimulation module, and the cervical mechanical stimulation unit; During the period and interval of applying mechanical pressure to the neck mechanical stimulation unit, the output intensity in the output parameters of the auditory stimulation module and the somatosensory stimulation module is adjusted synchronously.

[0017] Fifthly, this application provides a multimodal neuromodulation system based on EEG feedback, comprising: a head-mounted multimodal stimulation unit, an EEG monitoring unit, and a central control unit; both the head-mounted multimodal stimulation unit and the EEG monitoring unit are connected to the central control unit; the head-mounted multimodal stimulation unit includes a visual stimulation module, an auditory stimulation module, and a somatosensory stimulation module; The visual stimulation module is used to apply periodic light stimulation to the subject's eyes; The auditory stimulation module is used to apply periodic sound stimulation to the subject's ears; The somatosensory stimulation module is used to apply periodic somatosensory stimulation to the subject's head; The EEG monitoring unit is used to collect the subject's EEG signals and extract the steady-state evoked potential features of the γ oscillation frequency band; the steady-state evoked potential features include the power spectral density and / or phase lock value of the 40Hz±2Hz frequency band; The central control unit is used for: Based on the characteristics of steady-state evoked potentials, the output parameters of the visual stimulation module, the auditory stimulation module, and the somatosensory stimulation module are adjusted.

[0018] According to the specific embodiments provided in this application, the following technical effects are disclosed: This application discloses a multimodal neuromodulation and lymphatic drainage synergy system based on EEG feedback. Through visual stimulation, auditory stimulation, and somatosensory stimulation modules in a head-mounted multimodal stimulation unit, periodic light stimulation, sound stimulation, and somatosensory stimulation are applied to the subject's eyes, ears, and head, respectively. These three types of intracranial stimulation act on different sensory pathways, collectively driving intracranial gamma oscillations. Simultaneously, a neck mechanical stimulation unit applies periodic mechanical pressure to the superficial cervical lymphatic vessels, enhancing intracranial neural oscillations and coordinating extracranial lymphatic drainage in a temporal "production-excretion" sequence. The EEG monitoring unit collects the subject's EEG signals in real time and extracts the steady-state evoked potential characteristics of the γ oscillation band (power spectral density and / or phase lock value of the 40Hz±2Hz band). The central control unit adjusts the output parameters of each stimulation module according to the steady-state evoked potential characteristics, and synchronously adjusts the output intensity of the intracerebral stimulation module output parameters during the period and interval of mechanical pressure applied by the neck mechanical stimulation unit. This forms a closed-loop regulation based on real-time EEG feedback and temporal synergy between intracerebral and extracerebral systems, thereby realizing the synergistic intervention of multimodal intracerebral neuromodulation and extracerebral lymphatic drainage in a single system. Attached Figure Description

[0019] To more clearly illustrate the technical solutions in the embodiments of this application or related technologies, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0020] Figure 1 A schematic diagram of a multimodal neuromodulation and lymphatic drainage synergistic system based on EEG feedback provided in an embodiment of this application; Figure 2This is a schematic diagram of a multimodal neuromodulation system based on EEG feedback provided in an embodiment of this application. Detailed Implementation

[0021] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0022] The purpose of this application is to provide a multimodal neuromodulation and lymphatic drainage synergy system based on EEG feedback, which aims to solve the problems that it is difficult to coordinate intrabrain multimodal neuromodulation and extrabrain lymphatic drainage in the same system, and the lack of a dynamic synergistic regulation mechanism based on real-time EEG feedback in intrabrain multimodal neuromodulation.

[0023] To make the above-mentioned objectives, features and advantages of this application more apparent and understandable, the application will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0024] In one exemplary embodiment, such as Figure 1 As shown, a multimodal neuromodulation and lymphatic drainage synergy system based on EEG feedback is provided, including: a head-mounted multimodal stimulation unit, a neck mechanical stimulation unit, an EEG monitoring unit, and a central control unit; the head-mounted multimodal stimulation unit, the neck mechanical stimulation unit, and the EEG monitoring unit are all connected to the central control unit; the head-mounted multimodal stimulation unit includes a visual stimulation module, an auditory stimulation module, and a somatosensory stimulation module; The visual stimulation module is used to apply periodic light stimulation to the subject's eyes; The auditory stimulation module is used to apply periodic sound stimulation to the subject's two ears; The somatosensory stimulation module is used to apply periodic somatosensory stimulation to the subject's head; The neck mechanical stimulation unit is used to apply periodic mechanical pressure to the superficial lymphatic vessels of the subject's neck; The EEG monitoring unit is used to acquire the subject's EEG signals and extract steady-state evoked potential features in the gamma oscillation band; the steady-state evoked potential features include the power spectral density and / or phase lock value in the 40Hz±2Hz band; The central control unit is used for: Based on the characteristics of steady-state evoked potentials, adjust the output parameters of the visual stimulation module, auditory stimulation module, somatosensory stimulation module, and neck mechanical stimulation unit; During the period and interval of applying mechanical pressure to the neck mechanical stimulation unit, the output intensity of the output parameters of the visual stimulation module, auditory stimulation module and somatosensory stimulation module is adjusted synchronously.

[0025] Specifically, the EEG monitoring unit includes at least four EEG electrodes and a signal processor, used to acquire the subject's EEG signals in real time and extract steady-state evoked potential characteristics in the gamma oscillation band (30Hz-90Hz band, preferably 40Hz±2Hz).

[0026] Specifically, based on the characteristics of steady-state evoked potentials, the output parameters of at least one of the following modules or units—visual stimulation module, auditory stimulation module, somatosensory stimulation module, and neck mechanical stimulation unit—are adjusted.

[0027] The central control unit is configured as follows: (1) Adjust the output parameters of at least one module or unit among the visual stimulation module, auditory stimulation module, somatosensory stimulation module and neck mechanical stimulation unit according to the characteristics of steady-state evoked potentials; (2) When the steady-state evoked potential characteristics are lower than the preset target range (110%-150% of the subject's baseline γ oscillation power), the output intensity of the visual stimulation module, auditory stimulation module, and somatosensory stimulation module is increased in sequence. (3) When the steady-state evoked potential characteristics recover to the preset target range, the output intensity is gradually adjusted back; (4) During the application of mechanical pressure by the neck mechanical stimulation unit, the output intensity of at least one of the visual stimulation module, auditory stimulation module and somatosensory stimulation module is increased simultaneously (first temporal mode). (5) During the intervals when mechanical pressure is applied to the neck mechanical stimulation unit, increase the output intensity of at least one of the visual stimulation module, auditory stimulation module and somatosensory stimulation module, while decreasing or maintaining the output intensity during the application of mechanical pressure (second temporal mode, i.e. alternating mode). (7) It can switch between the first timing mode and the second timing mode.

[0028] Specifically, a personalized strategy database is set up in the central control unit to store the subject's historical EEG response data and corresponding stimulation parameter combinations.

[0029] As an optional implementation, the somatosensory stimulation module includes a first somatosensory stimulation unit and a second somatosensory stimulation unit; the first somatosensory stimulation unit is configured to stimulate at least one acupoint on the subject's head, and the second somatosensory stimulation unit is configured to stimulate at least one brain functional area on the subject's head.

[0030] Specifically, the acupoints include Baihui (GV20), Shenting (GV24), Fengchi (GB20), Benshen (GB13), Sishencong (EX-HN1), Shangxing (GV23), Tianzhu (BL10), and Anmian (EX-HN1); the brain functional areas include the prefrontal cortex and the temporal lobe.

[0031] As an optional implementation, the output frequencies of the visual stimulation module, auditory stimulation module, and somatosensory stimulation module are all 30Hz-90Hz.

[0032] Specifically, the visual stimulation module consists of an LED array embedded inside the head-mounted frame, used to apply periodic light stimulation to the subject at a frequency of 30Hz-90Hz (preferably 40Hz±2Hz). The layout of the LED array covers the visual field of both eyes, and the light output intensity can be adjusted in the range of 50lux-1000lux; preferably, the light output intensity is 100lux-800lux.

[0033] The auditory stimulation module consists of bone conduction or air conduction headphones, used to apply periodic sound stimulation at a frequency of 30Hz-90Hz (preferably 40Hz±2Hz) to the subject. The volume of the sound stimulation can be adjusted within the range of 40dB-75dB.

[0034] The output frequency of the sensory stimulation module is 30Hz-90Hz (preferably 40Hz±2Hz).

[0035] As an optional implementation, the mechanical pressure applied by the neck mechanical stimulation unit ranges from 0.01 kgf to 0.08 kgf, the compression frequency is once every 1.5 seconds to 3 seconds, and the duration of each application is 1.5 seconds to 2.5 seconds.

[0036] Specifically, the neck mechanical stimulation unit includes a force sensor and a contact head. The contact head is used to apply periodic mechanical pressure to the superficial lymphatic vessels of the subject's neck, and the force sensor is used to detect the mechanical pressure applied by the contact head and feed it back to the central control unit. The contact head is oval-shaped and made of medical-grade silicone or cotton.

[0037] As an optional implementation, the somatosensory stimulation module is a transcutaneous electrical stimulation module, and both the first somatosensory stimulation unit and the second somatosensory stimulation unit are electrodes; Among the electrode's output parameters, the current output intensity ranges from 0.5mA to 5mA, the pulse width ranges from 100μs to 300μs, and the waveform is a biphasic square wave.

[0038] Specifically, the electrodes corresponding to the first somatosensory stimulation unit include 5 contact points: 1 corresponding to Baihui acupoint (GV20), 4 corresponding to Sishencong acupoint (EX-HN1), and the contact points are evenly distributed around Baihui acupoint.

[0039] Specifically, when the somatosensory stimulation module is a transcutaneous electrical stimulation module, current is conducted to the target tissue through contact between electrodes and the skin, activating the somatosensory pathway and achieving precise stimulation of acupoints and brain functional areas.

[0040] As an optional implementation, the somatosensory stimulation module is a transcranial magnetic stimulation module, and both the first somatosensory stimulation unit and the second somatosensory stimulation unit are coils. Among the output parameters of the coil, the magnetic induction output intensity ranges from 0 to 20 mT, the frequency ranges from 1 Hz to 100 Hz, and the duty cycle ranges from 1% to 50%.

[0041] Specifically, when the somatosensory stimulation module is a transcranial magnetic stimulation module, the transcranial magnetic stimulation implementation method generates a time-varying magnetic field through a coil, which generates an induced electric field in the target tissue, activates the somatosensory pathway, and achieves non-contact stimulation of acupoints and brain functional areas.

[0042] When the system simultaneously includes a visual stimulation module, an auditory stimulation module, a somatosensory stimulation module, and a neck mechanical stimulation unit, the synergistic effect of the system in this embodiment stems from the organic integration of the following three levels: The first level (signal level): Light, sound, and physical stimuli all operate at the same frequency of 40Hz±2Hz, simultaneously driving gamma oscillations through different neural pathways in the visual cortex, auditory cortex, and somatosensory cortex, forming multi-pathway synchronous entrainment. A single modality can only activate a single sensory pathway, while the synergistic effect of light, sound, and physical multimodal stimulation can synchronously induce gamma oscillations in the visual cortex, auditory cortex, and somatosensory cortex, expanding the oscillation entrainment range from a single cortex to multiple sensory cortices and downstream brain regions (such as the hippocampus and prefrontal cortex), thereby achieving broader neural network synchronization. Regardless of whether the somatosensory stimulation uses electrical or magnetic stimulation, the same multi-pathway synchronous entrainment effect can be achieved. The second level (target level): The first somatosensory stimulation unit (acupoint) of the somatosensory stimulation module exerts a holistic regulatory effect through peripheral nerve reflexes, while the second somatosensory stimulation unit (brain functional area) achieves precise control of specific brain regions. The two stimulation units output at the same frequency (40Hz±2Hz), generated by frequency division from the same clock source, ensuring that the rising edges of the two stimuli are aligned in time, achieving synchronous regulation of the "peripheral-central" dual pathway. Single-target somatosensory stimulation can only act on either the peripheral or central pathway, while dual-target synergy can achieve synchronous regulation across target points, causing peripheral signals and central signals to superimpose in time. Both electrical stimulation and magnetic stimulation methods can achieve the above-mentioned dual-target synergistic effect. The third level (system level): Mechanical stimulation acts independently on the superficial cervical lymphatic vessels, forming a complete pathway of "upstream generation - downstream discharge" with the enhanced gamma oscillations in the brain. Metabolic waste products generated by enhanced neural activity in the brain are promptly cleared through synchronously enhanced extracerebral lymphatic drainage. The above three levels are progressive (signal → target → system), and each level is not independent but forms an organic whole through the coordinated scheduling of the central control unit.

[0043] In one exemplary embodiment, a multimodal neuromodulation and lymphatic drainage synergy system based on EEG feedback is provided, comprising: a head-mounted multimodal stimulation unit, a neck mechanical stimulation unit, an EEG monitoring unit, and a central control unit; the head-mounted multimodal stimulation unit, the neck mechanical stimulation unit, and the EEG monitoring unit are all connected to the central control unit; the head-mounted multimodal stimulation unit includes a visual stimulation module and an auditory stimulation module; The visual stimulation module is used to apply periodic light stimulation to the subject's eyes; The auditory stimulation module is used to apply periodic sound stimulation to the subject's two ears; The neck mechanical stimulation unit is used to apply periodic mechanical pressure to the superficial lymphatic vessels of the subject's neck; The EEG monitoring unit is used to acquire the subject's EEG signals and extract steady-state evoked potential features in the gamma oscillation band; the steady-state evoked potential features include the power spectral density and / or phase lock value in the 40Hz±2Hz band; The central control unit is used for: Based on the characteristics of steady-state evoked potentials, adjust the output parameters of the visual stimulation module, auditory stimulation module, and neck mechanical stimulation unit; During the period and interval of applying mechanical pressure to the neck mechanical stimulation unit, the output intensity in the output parameters of the visual stimulation module and the auditory stimulation module is adjusted synchronously.

[0044] Specifically, the output frequencies of both the visual stimulation module and the auditory stimulation module are 30Hz-90Hz (preferably 40Hz±2Hz).

[0045] When the system simultaneously includes a visual stimulation module, an auditory stimulation module, and a neck mechanical stimulation unit, the synergistic effect of the system in this embodiment is as follows: light stimulation and sound stimulation operate at the same frequency of 40Hz±2Hz, driving gamma oscillations in the visual cortex and auditory cortex, respectively; mechanical stimulation independently drives the drainage of superficial cervical lymphatic vessels through force-controlled pressure. The three components form a complete pathway of "intrabrain generation - extrabrain drainage" through the temporal coordination of the central control unit (synchronously enhancing light / sound stimulation during mechanical pressure, or alternately enhancing it during the interval).

[0046] In one exemplary embodiment, a multimodal neuromodulation and lymphatic drainage synergy system based on EEG feedback is provided, comprising: a head-mounted multimodal stimulation unit, a neck mechanical stimulation unit, an EEG monitoring unit, and a central control unit; the head-mounted multimodal stimulation unit, the neck mechanical stimulation unit, and the EEG monitoring unit are all connected to the central control unit; the head-mounted multimodal stimulation unit includes a visual stimulation module and a somatosensory stimulation module; The visual stimulation module is used to apply periodic light stimulation to the subject's eyes; The somatosensory stimulation module is used to apply periodic somatosensory stimulation to the subject's head; The neck mechanical stimulation unit is used to apply periodic mechanical pressure to the superficial lymphatic vessels of the subject's neck; The EEG monitoring unit is used to acquire the subject's EEG signals and extract steady-state evoked potential features in the gamma oscillation band; the steady-state evoked potential features include the power spectral density and / or phase lock value in the 40Hz±2Hz band; The central control unit is used for: Based on the characteristics of steady-state evoked potentials, adjust the output parameters of the visual stimulation module, the somatosensory stimulation module, and the neck mechanical stimulation unit; During the period and interval of applying mechanical pressure to the neck mechanical stimulation unit, the output intensity in the output parameters of the visual stimulation module and the somatosensory stimulation module is adjusted synchronously.

[0047] Specifically, the output frequency of both the visual stimulation module and the somatosensory stimulation module is 30Hz-90Hz (preferably 40Hz±2Hz).

[0048] When the system includes a visual stimulation module, a somatosensory stimulation module, and a neck mechanical stimulation unit, the synergistic effect of the system in this embodiment is as follows: light stimulation drives the visual cortex gamma oscillation, somatosensory stimulation (transcutaneous electrical stimulation or transcranial magnetic stimulation) acts on acupoints and brain functional areas simultaneously, and mechanical stimulation drives lymphatic drainage. The three form a cross-modal synergy of light, physics, and mechanics under unified frequency and temporal coordination.

[0049] In one exemplary embodiment, a multimodal neuromodulation and lymphatic drainage synergy system based on EEG feedback is provided, comprising: a head-mounted multimodal stimulation unit, a neck mechanical stimulation unit, an EEG monitoring unit, and a central control unit; the head-mounted multimodal stimulation unit, the neck mechanical stimulation unit, and the EEG monitoring unit are all connected to the central control unit; the head-mounted multimodal stimulation unit includes an auditory stimulation module and a somatosensory stimulation module; The auditory stimulation module is used to apply periodic sound stimulation to the subject's two ears; The somatosensory stimulation module is used to apply periodic somatosensory stimulation to the subject's head; The neck mechanical stimulation unit is used to apply periodic mechanical pressure to the superficial lymphatic vessels of the subject's neck; The EEG monitoring unit is used to acquire the subject's EEG signals and extract steady-state evoked potential features in the gamma oscillation band; the steady-state evoked potential features include the power spectral density and / or phase lock value in the 40Hz±2Hz band; The central control unit is used for: Based on the characteristics of steady-state evoked potentials, adjust the output parameters of the auditory stimulation module, the somatosensory stimulation module, and the neck mechanical stimulation unit; During the period and interval of applying mechanical pressure to the neck mechanical stimulation unit, the output intensity in the output parameters of the auditory stimulation module and the somatosensory stimulation module is adjusted synchronously.

[0050] Specifically, the output frequency of both the visual stimulation module and the somatosensory stimulation module is 30Hz-90Hz (preferably 40Hz±2Hz).

[0051] When the system includes an auditory stimulation module, a somatosensory stimulation module, and a neck mechanical stimulation unit, the synergistic effect of the system in this embodiment is as follows: acoustic stimulation drives the gamma oscillation of the auditory cortex, somatosensory stimulation (transcutaneous electrical stimulation or transcranial magnetic stimulation) acts on acupoints and brain functional areas simultaneously, and mechanical stimulation drives lymphatic drainage, forming a cross-modal synergy of sound-physical-mechanical interaction.

[0052] In one exemplary embodiment, such as Figure 2 As shown, a multimodal neuromodulation system based on EEG feedback is provided, including: a head-mounted multimodal stimulation unit, an EEG monitoring unit, and a central control unit; both the head-mounted multimodal stimulation unit and the EEG monitoring unit are connected to the central control unit; the head-mounted multimodal stimulation unit includes a visual stimulation module, an auditory stimulation module, and a somatosensory stimulation module; The visual stimulation module is used to apply periodic light stimulation to the subject's eyes; The auditory stimulation module is used to apply periodic sound stimulation to the subject's two ears; The somatosensory stimulation module is used to apply periodic somatosensory stimulation to the subject's head; The EEG monitoring unit is used to acquire the subject's EEG signals and extract steady-state evoked potential features in the gamma oscillation band; the steady-state evoked potential features include the power spectral density and / or phase lock value in the 40Hz±2Hz band; The central control unit is used for: Based on the characteristics of steady-state evoked potentials, the output parameters of the visual stimulation module, auditory stimulation module, and somatosensory stimulation module are adjusted.

[0053] Specifically, the output frequencies of the visual stimulation module, auditory stimulation module, and somatosensory stimulation module are all 30Hz-90Hz (preferably 40Hz±2Hz).

[0054] When the system includes a visual stimulation module, an auditory stimulation module, and a somatosensory stimulation module, the synergistic effect of the system in this embodiment is as follows: the light, sound, and physical modes all operate at the same frequency of 40Hz±2Hz, driving γ oscillations simultaneously through the visual cortex, auditory cortex, and somatosensory cortex, respectively, so that the range of oscillations extends to multiple sensory cortices and downstream brain regions.

[0055] The system described in this application can be used as an adjunct intervention for neurodegenerative diseases such as Alzheimer's disease. Users can utilize it in medical institutions or at home. The relevant instructions for use are as follows.

[0056] Related instructions 1. Wearing and initialization of the device.

[0057] Place the head-mounted multimodal stimulation unit on the user's head and adjust the frame to a comfortable position using the adjustment mechanism, ensuring that: 1) the center of the LED array of the visual stimulation module is aligned with the midpoint of the line connecting the pupils of both eyes; 2) the bone conduction headphones of the auditory stimulation module are in close contact with the mastoid regions on both sides; 3) the contact points of the first somatosensory stimulation unit (acupoint stimulation unit) are respectively pressed on the surface projection areas of Baihui (GV20), Sishencong (EX-HN1), Shenting (GV24), Fengchi (GB20), Benshen (GB13), Shangxing (GV23), Tianzhu (BL10), and Anmian (EX-HN17) acupoints, and some acupoints can be selected for stimulation as needed; 4) the contact points of the second somatosensory stimulation unit (brain function area stimulation unit) are respectively pressed on the prefrontal and temporal lobe areas.

[0058] The cervical mechanical stimulation unit is worn on the neck, and the contact head is adjusted to cover the superficial cervical lymphatic vessels between the angle of the mandible and the upper edge of the clavicle. The force sensor is zeroed to ensure that the contact head maintains a light contact with the skin (initial pressure <0.005 kgf).

[0059] The EEG monitoring unit's lead electrodes are brought into contact with the user's scalp for impedance testing. Once all lead impedances are confirmed to be within the effective range, the system enters standby mode.

[0060] Related Explanation 2: Multimodal collaborative closed-loop control logic.

[0061] After the system is worn and started according to the relevant instructions 1, each stimulation module outputs its initial parameters: the visual stimulation module outputs light stimulation at 40Hz and 500 lux; the auditory stimulation module outputs sound stimulation at 40Hz and 60dB; the somatosensory stimulation module outputs at 40Hz (if it is an electrical stimulation implementation, the pulse width is 200μs, the current of the first stimulation unit is 2mA, and the current of the second stimulation unit is 1.5mA; if it is a magnetic stimulation implementation, the magnetic induction intensity is 10mT and the duty cycle is 25%); the neck mechanical stimulation unit is on standby.

[0062] The EEG monitoring unit extracts the power spectral density value of the 40Hz±2Hz frequency band in real time with a period of 100ms. The central control unit compares this real-time value with a preset target range (set to 120%~140% of the baseline value measured by the user in the resting state stored in the device's memory).

[0063] Scenario 1 (Stimulation Enhancement Logic): If the real-time gamma power is lower than the target range lower limit within three consecutive evaluation cycles (i.e., 300ms), the central control unit issues control commands sequentially according to preset priorities: First, the light intensity of the visual stimulation module is increased by 10%; if the gamma power still does not meet the target after 500ms, the sound pressure of the auditory stimulation module is increased by 3dB; if it still does not meet the target, the intensity of the somatosensory stimulation module is increased (electric stimulation: current +0.2mA; magnetic stimulation: magnetic induction intensity +1mT). This priority strategy is preset based on the power consumption, comfort, and duration of action of each modality.

[0064] Scenario 2 (First Sequence Mode - Synchronous Enhancement): When the drive mechanism of the neck mechanical stimulation unit is activated, and the contact head presses the superficial cervical lymphatic vessel area with a pressure of 0.015 kgf, the central control unit simultaneously sends instructions to the visual, auditory, and somatosensory stimulation modules, increasing the output intensity of the three by 15% during the continuous pressure period. During the pressure interval, the three return to their basic output values.

[0065] Scenario 3 (Second Timing Mode - Alternating Enhancement): In another preferred embodiment, the central control unit adopts a timing strategy opposite to that in Scenario 2: when the neck mechanical stimulation unit starts pressing, the central control unit sends instructions to the visual, auditory and somatosensory stimulation modules to reduce the output intensity of the three by 20% or maintain the baseline value during the pressing period; when the pressing ends and enters the interval (about 1-2 seconds), the output intensity of the three is simultaneously enhanced by 15%.

[0066] This alternating pattern is based on the following physiological considerations: during mechanical compression, lymphatic vessels are emptied by pressure, and reducing the intensity of intracranial stimulation at this time can reduce the instantaneous production of metabolic waste; during the interval, lymphatic vessels refill, and increasing intracranial stimulation at this time can promote gamma oscillations and the production of metabolic waste, which is then expelled during the next compression. This forms an alternating rhythm of "production-expulsion," simulating the periodic coordination between intracranial metabolic activity and lymphoid clearance under physiological conditions.

[0067] The system can switch between "Synchronous Enhancement Mode" (Scenario 2) and "Alternating Mode" (Scenario 3) through the mode selection module to adapt to the physiological state and treatment stage of different users.

[0068] Scenario 4 (Stimulus callback logic): If the gamma power fed back by the EEG monitoring unit recovers to the target range within a certain adjustment cycle, the central control unit will gradually callback the parameters of each module back to the level before the adjustment in reverse order.

[0069] Related Explanation 3: Three-modal implementation method (excluding somatosensory stimulation - visual + auditory + mechanical + closed loop).

[0070] After system startup, the visual stimulation module outputs light stimulation at 40Hz and 500 lux, the auditory stimulation module outputs sound stimulation at 40Hz and 60dB, and the neck mechanical stimulation unit is on standby. The EEG monitoring unit extracts the power spectral density value of the 40Hz±2Hz frequency band in real time with a period of 100ms.

[0071] The closed-loop control logic of the central control unit is basically the same as that in related description 2, with the following differences: 1) When the γ power is lower than the target range, the central control unit sequentially enhances the light stimulation and sound stimulation (priority: light intensity → sound pressure); 2) During mechanical pressing, the output intensity of light stimulation and sound stimulation is simultaneously enhanced (synchronous mode), or alternately enhanced during the pressing interval (alternating mode).

[0072] Related Explanation 4: Trimodal Implementation Method (excluding mechanical stimulation - visual + auditory + somatosensory + closed loop).

[0073] The system structure of this embodiment is basically the same as that in related description 1, except that it does not include a neck mechanical stimulation unit. The configuration of the head-mounted multimodal stimulation unit (visual stimulation module, auditory stimulation module, and somatosensory stimulation module), EEG monitoring unit, and central control unit is the same as in related description 1.

[0074] After system startup, the visual stimulation module outputs 40Hz, 500lux light stimulation, the auditory stimulation module outputs 40Hz, 60dB sound stimulation, and the somatosensory stimulation module outputs at 40Hz (electrical stimulation: pulse width 200μs, first stimulation unit current 2mA, second stimulation unit current 1.5mA; magnetic stimulation: magnetic induction intensity 10mT, duty cycle 25%). The EEG monitoring unit extracts the power spectral density value of the 40Hz±2Hz frequency band in real time with a period of 100ms.

[0075] The closed-loop control logic of this embodiment is basically the same as that in related description 2, except that: since it does not contain a neck mechanical stimulation unit, the central control unit does not need to execute the timing coordination logic, but only needs to dynamically adjust the parameters of the three stimuli of light, sound, and physical stimulation according to the γ power feedback. When the γ power is lower than the target range, the light stimulation (light intensity +10%), sound stimulation (sound pressure +3dB), and somatosensory stimulation (electric stimulation: current +0.2mA; magnetic stimulation: magnetic induction intensity +1mT) are increased sequentially; when the γ power recovers to the target range, the parameters are gradually adjusted back.

[0076] Although this implementation does not include mechanical stimulation, the three types of stimulation—light, sound, and physical—all operate at the same frequency of 40Hz, simultaneously driving gamma oscillations through different neural pathways in the visual cortex, auditory cortex, and somatosensory cortex, thus achieving multi-pathway synchronous entrainment. If a neck mechanical stimulation unit is added on this basis (i.e., upgraded to the complete scheme described in related description 1), it is possible to further achieve dual-pathway synergy of "generated in the brain and expelled from the brain".

[0077] Related Note 5: Three-modal implementation method (excluding auditory or visual stimulation).

[0078] This embodiment briefly describes the system configuration and working logic of the third and fourth embodiments.

[0079] (1) Visual + somatosensory + mechanical + closed loop, without auditory stimulation: The system structure is basically the same as the relevant description 1. The difference is that the head-mounted stimulation unit does not include an auditory stimulation module, but only a visual stimulation module, a somatosensory stimulation module (dual target), a neck mechanical stimulation unit, an EEG monitoring unit and a central control unit.

[0080] The working logic is basically the same as the relevant description 2, with the following differences: 1) There is no auditory stimulation output in the initial parameters; 2) The central control unit only needs to adjust the output parameters of the visual stimulation module and the somatosensory stimulation module; 3) When the γ power is lower than the target range, the priority is: light intensity → somatosensory stimulation intensity; 4) Light stimulation and somatosensory stimulation are enhanced simultaneously during mechanical pressing, or alternately enhanced during the interval.

[0081] (2) Hearing + somatosensory + mechanical + closed loop, without visual stimulation: The system structure is basically the same as the relevant description 1. The difference is that the head-mounted stimulation unit does not include a visual stimulation module, but only includes an auditory stimulation module, a somatosensory stimulation module (dual target), a neck mechanical stimulation unit, an EEG monitoring unit and a central control unit.

[0082] The working logic is basically the same as the relevant description 2, with the following differences: 1) There is no visual stimulus output in the initial parameters; 2) The central control unit only needs to adjust the output parameters of the auditory stimulation module and the somatosensory stimulation module; 3) When the γ power is lower than the target range, the priority is: sound pressure → somatosensory stimulation intensity; 4) The sound stimulation and somatosensory stimulation are enhanced synchronously during mechanical pressing, or alternately enhanced during the interval.

[0083] Both implementation methods are based on 40Hz synchronous synergy, and achieve dual-pathway intervention by synergizing the three modes of "visual-somatosensory-mechanical" and "auditory-somatosensory-mechanical" respectively to enhance intracranial gamma oscillation and extracranial lymphatic drainage.

[0084] It should be noted that the user information (including but not limited to user device information, user personal information, etc.) and data (including but not limited to data used for analysis, data stored, data displayed, etc.) involved in this application are all information and data authorized by the user or fully authorized by all parties, and the collection, use and processing of the relevant data must comply with relevant regulations.

[0085] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0086] This document uses specific examples to illustrate the principles and implementation methods of this application. The descriptions of the above embodiments are only for the purpose of helping to understand the system and core ideas of this application. Furthermore, those skilled in the art will recognize that, based on the ideas of this application, there will be changes in the specific implementation methods and application scope. Therefore, the content of this specification should not be construed as a limitation of this application.

Claims

1. A multimodal neural modulation and lymphatic drainage synergistic system based on electroencephalographic feedback, characterized in that, include: The device includes a head-mounted multimodal stimulation unit, a neck mechanical stimulation unit, an electroencephalogram (EEG) monitoring unit, and a central control unit; the head-mounted multimodal stimulation unit, the neck mechanical stimulation unit, and the EEG monitoring unit are all connected to the central control unit; the head-mounted multimodal stimulation unit includes a visual stimulation module, an auditory stimulation module, and a somatosensory stimulation module. The visual stimulation module is used to apply periodic light stimulation to the subject's eyes; The auditory stimulation module is used to apply periodic sound stimulation to the subject's ears; The somatosensory stimulation module is used to apply periodic somatosensory stimulation to the subject's head; The neck mechanical stimulation unit is used to apply periodic mechanical pressure to the superficial lymphatic vessels of the subject's neck. The EEG monitoring unit is used to collect the subject's EEG signals and extract the steady-state evoked potential features of the γ oscillation frequency band; the steady-state evoked potential features include the power spectral density and / or phase lock value of the 40Hz±2Hz frequency band; The central control unit is used for: Based on the characteristics of steady-state evoked potentials, adjust the output parameters of the visual stimulation module, the auditory stimulation module, the somatosensory stimulation module, and the neck mechanical stimulation unit; During the period and interval of applying mechanical pressure to the neck mechanical stimulation unit, the output intensity of the output parameters of the visual stimulation module, the auditory stimulation module and the somatosensory stimulation module is adjusted synchronously.

2. The multimodal neuromodulation and lymphatic drainage synergistic system based on EEG feedback according to claim 1, characterized in that, The somatosensory stimulation module includes a first somatosensory stimulation unit and a second somatosensory stimulation unit; the first somatosensory stimulation unit is configured to stimulate at least one acupoint on the subject's head, and the second somatosensory stimulation unit is configured to stimulate at least one brain functional area on the subject's head.

3. The multimodal neuromodulation and lymphatic drainage synergistic system based on EEG feedback according to claim 2, characterized in that, The output frequencies of the visual stimulation module, the auditory stimulation module, and the somatosensory stimulation module are all 30Hz-90Hz.

4. The multimodal neural modulation and lymphatic drainage synergistic system based on EEG feedback according to claim 1, characterized in that, The mechanical pressure applied by the neck mechanical stimulation unit ranges from 0.01 kgf to 0.08 kgf, with a pressing frequency of once every 1.5 to 3 seconds, and each application lasting for 1.5 to 2.5 seconds.

5. The multimodal neuromodulation and lymphatic drainage synergistic system based on EEG feedback according to claim 2, characterized in that, The somatosensory stimulation module is a transcutaneous electrical stimulation module, and both the first somatosensory stimulation unit and the second somatosensory stimulation unit are electrodes. The output parameters of the electrode include a current output intensity range of 0.5mA-5mA, a pulse width range of 100μs-300μs, and a biphasic square wave waveform.

6. The multimodal neuromodulation and lymphatic drainage synergistic system based on EEG feedback according to claim 2, characterized in that, The somatosensory stimulation module is a transcranial magnetic stimulation module, and both the first somatosensory stimulation unit and the second somatosensory stimulation unit are coils. The output parameters of the coil include a magnetic induction output intensity range of 0-20mT, a frequency range of 1Hz-100Hz, and a duty cycle range of 1%-50%.

7. A multimodal neural modulation and lymphatic drainage synergistic system based on electroencephalographic feedback, characterized in that, include: The device includes a head-mounted multimodal stimulation unit, a neck mechanical stimulation unit, an electroencephalogram (EEG) monitoring unit, and a central control unit; the head-mounted multimodal stimulation unit, the neck mechanical stimulation unit, and the EEG monitoring unit are all connected to the central control unit; the head-mounted multimodal stimulation unit includes a visual stimulation module and an auditory stimulation module. The visual stimulation module is used to apply periodic light stimulation to the subject's eyes; The auditory stimulation module is used to apply periodic sound stimulation to the subject's ears; The neck mechanical stimulation unit is used to apply periodic mechanical pressure to the superficial lymphatic vessels of the subject's neck. The EEG monitoring unit is used to collect the subject's EEG signals and extract the steady-state evoked potential features of the γ oscillation frequency band; the steady-state evoked potential features include the power spectral density and / or phase lock value of the 40Hz±2Hz frequency band; The central control unit is used for: Based on the characteristics of steady-state evoked potentials, adjust the output parameters of the visual stimulation module, the auditory stimulation module, and the neck mechanical stimulation unit; During the period and interval of applying mechanical pressure to the neck mechanical stimulation unit, the output intensity in the output parameters of the visual stimulation module and the auditory stimulation module is adjusted synchronously.

8. A multimodal neural modulation and lymphatic drainage synergistic system based on electroencephalographic feedback, characterized in that, include: The device includes a head-mounted multimodal stimulation unit, a neck mechanical stimulation unit, an electroencephalogram (EEG) monitoring unit, and a central control unit; the head-mounted multimodal stimulation unit, the neck mechanical stimulation unit, and the EEG monitoring unit are all connected to the central control unit; the head-mounted multimodal stimulation unit includes a visual stimulation module and a somatosensory stimulation module. The visual stimulation module is used to apply periodic light stimulation to the subject's eyes; The somatosensory stimulation module is used to apply periodic somatosensory stimulation to the subject's head; The neck mechanical stimulation unit is used to apply periodic mechanical pressure to the superficial lymphatic vessels of the subject's neck. The EEG monitoring unit is used to collect the subject's EEG signals and extract the steady-state evoked potential features of the γ oscillation frequency band; the steady-state evoked potential features include the power spectral density and / or phase lock value of the 40Hz±2Hz frequency band; The central control unit is used for: Based on the characteristics of steady-state evoked potentials, adjust the output parameters of the visual stimulation module, the somatosensory stimulation module, and the neck mechanical stimulation unit; During the period and interval of applying mechanical pressure to the neck mechanical stimulation unit, the output intensity in the output parameters of the visual stimulation module and the somatosensory stimulation module is adjusted synchronously.

9. A multimodal neural modulation and lymphatic drainage synergistic system based on electroencephalographic feedback, characterized in that, include: The device includes a head-mounted multimodal stimulation unit, a neck mechanical stimulation unit, an electroencephalogram (EEG) monitoring unit, and a central control unit; the head-mounted multimodal stimulation unit, the neck mechanical stimulation unit, and the EEG monitoring unit are all connected to the central control unit; the head-mounted multimodal stimulation unit includes an auditory stimulation module and a somatosensory stimulation module. The auditory stimulation module is used to apply periodic sound stimulation to the subject's ears; The somatosensory stimulation module is used to apply periodic somatosensory stimulation to the subject's head; The neck mechanical stimulation unit is used to apply periodic mechanical pressure to the superficial lymphatic vessels of the subject's neck. The EEG monitoring unit is used to collect the subject's EEG signals and extract the steady-state evoked potential features of the γ oscillation frequency band; the steady-state evoked potential features include the power spectral density and / or phase lock value of the 40Hz±2Hz frequency band; The central control unit is used for: Based on the characteristics of steady-state evoked potentials, adjust the output parameters of the auditory stimulation module, the somatosensory stimulation module, and the cervical mechanical stimulation unit; During the period and interval of applying mechanical pressure to the neck mechanical stimulation unit, the output intensity in the output parameters of the auditory stimulation module and the somatosensory stimulation module is adjusted synchronously.

10. A multimodal neural modulation system based on electroencephalographic feedback, characterized in that, include: The device includes a head-mounted multimodal stimulation unit, an electroencephalogram (EEG) monitoring unit, and a central control unit; both the head-mounted multimodal stimulation unit and the EEG monitoring unit are connected to the central control unit; the head-mounted multimodal stimulation unit includes a visual stimulation module, an auditory stimulation module, and a somatosensory stimulation module. The visual stimulation module is used to apply periodic light stimulation to the subject's eyes; The auditory stimulation module is used to apply periodic sound stimulation to the subject's ears; The somatosensory stimulation module is used to apply periodic somatosensory stimulation to the subject's head; The EEG monitoring unit is used to collect the subject's EEG signals and extract the steady-state evoked potential features of the γ oscillation frequency band; the steady-state evoked potential features include the power spectral density and / or phase lock value of the 40Hz±2Hz frequency band; The central control unit is used for: Based on the characteristics of steady-state evoked potentials, the output parameters of the visual stimulation module, the auditory stimulation module, and the somatosensory stimulation module are adjusted.

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