Method of making an animal model

Abstract

This invention provides a method for creating an animal model that reproduces the abnormal state of the fundus caused by axial elongation. The method includes a step of raising an animal under myopia induction for a specific period, wherein the specific period is at least 1.5 times the period from the induction of myopia until the reduction in refractive power reaches a plateau.

Claims

1. A method for creating an animal model, comprising procedures for raising animals under myopia-induced conditions for a specific period of time. The specific period is more than 1.5 times the period from the induction of myopia until the reduction of refractive power reaches the plateau period.

2. The method according to claim 1, wherein, The animals mentioned are rodents, shrews, or rabbits.

3. The method according to claim 1, wherein, The procedure further includes a step to confirm that the fundus abnormality in the animal has been induced.

4. The method according to claim 1, wherein, The myopia induction is performed by applying a negative lens to the animal, and the method includes: The procedure of raising the animal with the negative lens positioned separately from the eye in front of the animal's eyes, and The process of adjusting the positional relationship between the negative lens and the eye and / or the power of the negative lens according to the growth of the animal.

5. The method according to claim 4, wherein, In the feeding process, a method is further applied to prevent any part of the animal's body from coming into contact with the negative lens and / or the eye.

6. The method according to claim 1, wherein, The myopia induction is achieved by administering a myopia induction agent.

7. A method for evaluating or screening compositions for the prevention or improvement of pathological myopia or eye diseases related to axial elongation, comprising: Procedures for raising animals under myopia induction during specific periods, and The procedure of administering the test substance to the animal; The specific period is more than 1.5 times the period from the onset of myopia to the plateau phase of refractive error reduction. The test substance may be administered at the beginning of the specified period, during the specified period, or after the specified period.

8. The method according to claim 7, wherein, The test substance is administered after the reduction in refractive power reaches a plateau following the induction of myopia.

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