A suspension containing tolclofos-methyl and ziram and its preparation and application

Abstract

The present application relates to a kind of suspending agent containing tetraconazole and ziram, and its formula includes tetraconazole, ziram, dispersing agent, emulsifying dispersant, humectant, synergist, antifreezing agent, preservative, antifoaming agent, thickening agent and deionized water.The present application can improve the suspension rate, stability and other indicators of suspending agent preparation by screening specific adjuvants, especially dispersing agent, emulsifying dispersant, humectant, synergist and thickening agent, while improving the field effect of preparation.

Description

Technical Field

[0001] This invention relates to the field of pesticide formulations, specifically to a suspension containing tetrazolium pyridaben and benzyme. Background Technology

[0002] Picarbutrazox is a tetrazolium oxime fungicide developed by Nippon Soda Co., Ltd. Its unique mechanism of action involves inhibiting pathogen cell membrane synthesis, hindering spore germination and hyphal elongation, and reducing zoospore production. It exhibits both penetrating and curative effects, effectively controlling diseases caused by oomycetes, such as those caused by *Plasmodium*, *Pythium*, *Pseudomonas*, and *Phytophthora*. It demonstrates excellent control over downy mildew and blight in crops. It is widely applicable to crops including soybeans, corn, rice, cucumbers, melons, watermelons, tomatoes, lettuce, broccoli, cabbage, Chinese cabbage, onions, radishes, spinach, potatoes, gourds, and lawns. Application methods include foliar spraying, soil treatment, and seed treatment.

[0003] Zoxamide is a highly effective, low-toxicity, protective fungicide specifically formulated for oomycetes, belonging to the benzamide class. It binds tightly to the β-subunit of tubulin in oomycetes, leading to the rupture of the microtubule cytoskeleton, inhibiting cell division, and hindering germ tube elongation and plant infection. It does not affect spore motility or sporangium formation, and pathogens are unlikely to develop resistance rapidly in the field. It is mainly used to control oomycete diseases, including potato late blight, tomato late blight, cucumber downy mildew, grape downy mildew, and taro blight.

[0004] CN106922703A discloses a fungicide composition comprising the active ingredient tetrazolium pyraclostrobin and at least one amide fungicide, including picarbutrazox, fluopyram, thifluzamide, cyclophosphamide, dimethomorph, dimethomorph, fluopyram, fluopyram, imidacloprid, benzymazole, or benzymazole. The weight ratio of picarbutrazox to at least one amide fungicide is 100:1 to 1:100. By combining picarbutrazox with at least one amide fungicide in a binary formulation, this invention exhibits a significant synergistic effect in controlling fungal and bacterial diseases in crops. This document specifically describes the synergistic effect of tetrazolium pyraclostrobin and benzymazole in controlling cucumber downy mildew.

[0005] CN107232216A discloses a fungicide composition containing tetrazolium pyridaben and an amide fungicide. The effective active ingredients consist of tetrazolium pyridaben as the first active ingredient and an amide fungicide as the second active ingredient. The amide fungicide is one of dimethomorph, flumorph, fluopyram, or benzyme. The composition can be formulated into agriculturally permissible wettable powders, water-dispersible granules, suspensions, emulsions, water-in-oil emulsions, microemulsions, microcapsule suspensions, etc. The composition exhibits good fungicidal effect; compared with existing single-component formulations, it not only has a significant fungicidal effect but also a significant synergistic effect, showing significant control effects against downy mildew and blight in crops. Formulation Example 8 discloses a 25% tetrazolium pyridaben·benzyme suspension formulation, but does not provide specific details regarding its formulation selection and quality performance indicators.

[0006] While the aforementioned existing technical literature discloses compositions containing tetrazolium pyridaben and benzylamidophos, its focus is on the compounding of active ingredients, lacking in-depth research on the formulation of these compound compositions. Although some literature mentions that the compositions can be prepared as suspensions, there is a lack of systematic screening and testing of various functional adjuvants in the suspensions and the performance indicators of the formulations. Existing technology lacks in-depth research on the formulation of tetrazolium pyridaben and benzylamidophos suspensions. Summary of the Invention

[0007] To address the aforementioned problems in the existing technology, this invention screens various key functional additives to prepare a tetrazolium-benzoyl sulfadiazine suspension with excellent performance in all quality indicators.

[0008] This invention is accomplished through the following technical solution.

[0009] This invention relates in one aspect to a suspension containing tetrazolium pyridamole and benzylamine, which is composed of the following components in weight percentage: Tetraazolylpyridinium, 20-40% Benzoylamidone, 5-15% Dispersant, 2-7% Emulsifying dispersant, 1-5% Moisturizer, 1-4% Synergist, 0.4-2% Antifreeze, 3-7% Preservatives, 0-0.2% Defoamer, 0.05-0.2% Thickener, 0.5-2% Add deionized water to bring the total to 100%.

[0010] In one embodiment of the present invention, the preferred weight percentage of each component is: Tetrazopyridine, 25-35% Benzoylamidone, 8-13% Dispersant, 3-5% Emulsifying dispersant, 2-4% Moisturizer, 2-3% Synergist, 0.5-1% Antifreeze, 4-6% Preservative, 0.1-0.2% Defoamer, 0.08-0.12% Thickener, 0.8-1.5% Add deionized water to bring the total to 100%.

[0011] In the suspension containing tetrazolium pyridamole and benzylamine described in this invention: The weight ratio of tetrazolium pyraclostrobin to benzyl benzoate is 10:1 to 1:10, preferably 5:1 to 1:5, and more preferably 3:1 to 1:1.

[0012] The dispersant is preferably a modified comb-type block polycarboxylate; more preferably ULTRASURF 7023A (Yijingfeng).

[0013] The emulsifying dispersant is preferably EO / PO block polyether; more preferably, it is one of ULTRASURF 8406 (Yijingfeng) and ULTRASURF 8070 (Yijingfeng); most preferably, it is ULTRASURF 8070 (Yijingfeng).

[0014] The humectant is preferably polyvinyl acetate; more preferably Filmer-17 (Dow Chemical).

[0015] The synergist is preferably a polyether-modified trisiloxane; more preferably SP-408 (Qingyu).

[0016] The antifreeze is preferably one or more of ethylene glycol and propylene glycol, more preferably ethylene glycol.

[0017] The preservative is preferably one or two of BIT and sodium benzoate; more preferably BIT-20 (Wanhou Bio).

[0018] The defoamer is preferably one or more of n-octanol, isobutyl phosphate, and polydimethylsiloxane; more preferably polydimethylsiloxane; and most preferably SAG 1572 (Nanjing Jierun).

[0019] The thickener is preferably one or more of sodium carboxymethyl cellulose, magnesium aluminum silicate, sodium alginate, xanthan gum, and magnesium silicate. More preferably, it is a combination of magnesium aluminum silicate and xanthan gum (the weight ratio of the two is 8-12:1, preferably 10:1) or magnesium silicate. More preferably, it is magnesium silicate.

[0020] This invention, through the screening of functional additives in the formulation, especially dispersants, emulsifying dispersants and their compatibility, humectants, synergists, thickeners, etc., has resulted in a suspension that exhibits excellent performance in various indicators such as stability, suspension rate, rainwater erosion resistance, and permeability. This is highly beneficial to the stability and efficacy of the suspension.

[0021] Another aspect of the present invention relates to a method for preparing a suspension containing tetrazolium pyridamole and benzylpyridinium, comprising the following steps: (1) Weigh and measure the required materials; (2) Add deionized water, dispersant, emulsifying dispersant and 1 / 3 of the defoamer into the shearing pot for shearing and dispersion; (3) Add tetrazolium pyraclostrobin technical and benzylamane technical into a shearing pot, disperse them evenly, then add a mixture of antifreeze and thickener, shear for 20-40 min, preferably 30 min, then add 1 / 3 of the defoamer, and then grind in a sand mill. During sand milling, control the particle size D90 to be less than 3.0 μm. (4) After the sand milling is completed, the sample is sent for wet sieve testing. After the wet sieve is qualified, it is transferred to the mixing kettle, and preservative, humectant, synergist, residual defoamer and optional residual thickener are added. After shearing for 20-40 minutes, preferably 30 minutes, the suspension product containing tetrazolium pyridamole and benzyme is obtained as described in this invention.

[0022] In the preparation method described in this invention, the thickener is usually added in step (3). However, when the thickener is a combination of magnesium aluminum silicate and xanthan gum, magnesium aluminum silicate and 1 / 3 xanthan gum are added in step (3); the remaining 2 / 3 xanthan gum is added in step (4). The purpose of adding xanthan gum in stages is, on the one hand, to reduce the sedimentation of materials before sand milling due to gravity, which would prevent continuous production; on the other hand, to avoid the thickening performance of xanthan gum decreasing due to repeated grinding during sand milling.

[0023] In the preparation method described in this invention, the purpose of adding the defoamer in stages is, on the one hand, to reduce the generation of bubbles during shearing and stirring; on the other hand, to defoam the ground material more quickly without reducing the defoaming effect.

[0024] In the preparation method of the present invention, the wet sieve qualification means that the proportion of the sieve passing through the 75μm test sieve is ≥98%.

[0025] Another aspect of this invention relates to the application of the suspension containing tetrazolium pyraclostrobin and benzoylmide for the prevention and control of agricultural diseases. It is preferably used to control diseases caused by oomycete pathogens, including but not limited to diseases caused by pathogens of the genera *Peronospora*, *Pseudomonas*, *Pythium*, and *Phytophthora*. It has a wide range of applicable crops, including but not limited to cucumbers, melons, peppers, taro, watermelons, tomatoes, soybeans, corn, rice, lettuce, broccoli, cabbage, Chinese cabbage, winter melon, spinach, potatoes, grapes, strawberries, and gourds. Preferably, the suspension of this invention is suitable for controlling plant diseases including taro blight, cucumber damping-off, tomato damping-off, winter melon cottony rot, watermelon cottony rot, corn root rot, soybean root rot, potato late blight, tomato late blight, pepper blight, grape downy mildew, strawberry blight, and cucumber downy mildew, and more preferably for controlling taro blight. The suspension of this invention can be used by foliar spraying, soil treatment, and seed treatment, with foliar spraying being preferred.

[0026] In the application of this invention, the suspension containing tetrazolium pyridamole and benzyme is applied by spraying after dilution, and the application amount is well known to those skilled in the art.

[0027] Beneficial effects 1. The compound formulation has a significant synergistic effect and higher bactericidal activity. Tetracycline and benzyme have different mechanisms of action and complementary fungicidal spectrum. When combined, they show a significant synergistic effect on oomycete diseases such as taro blight, with a co-toxicity coefficient significantly greater than 120. Under the same dosage of active ingredient, the control efficacy is much higher than that of single agents, which can reduce the amount of pesticides used.

[0028] 2. The suspension system is stable and has excellent storage properties over time. Using modified comb-type block polycarboxylate and EO / PO block polyether as a wetting and dispersion system can significantly reduce grinding viscosity, improve dispersion efficiency, effectively suppress particle size rebound after heat storage, and produce a suspension with high suspension rate, no stratification, no sedimentation, no water separation, and meets the standards for low temperature and heat storage stability, making it suitable for long-term storage and long-distance transportation.

[0029] 3. Excellent resistance to rain erosion and significantly extended effective period. Adding polyvinyl acetate emulsion moisturizer to the compound system can form a continuous, flexible, and transparent waterproof film on crop leaves, significantly improving the adhesion of the pesticide solution. If it rains 2 hours after application, there is no need to re-spray. It can maintain stable efficacy in rainy and humid areas, and the effective period is extended by 3-5 days.

[0030] 4. Significantly enhances wetting, spreading, and penetration effects, resulting in high pesticide utilization. Combined with polyether-modified trisiloxane synergist, it significantly reduces the surface tension of the pesticide solution, allowing it to spread over a large area, adhere evenly, and penetrate quickly on the waxy and hydrophobic leaves of taro. This significantly improves the absorption and utilization rate of the pesticide, reduces pesticide loss, and further enhances the control effect.

[0031] 5. The formulation is safe and environmentally friendly, and highly safe for crops. This invention is a water-based suspension agent that does not contain organic solvents and is environmentally friendly. It does not use film-forming aids that are prone to causing phytotoxicity, and is safe and non-phytotoxic to taro plants, leaves, and petioles. It does not inhibit growth, does not pollute the leaf surface, and does not affect the quality of agricultural products.

[0032] 6. Delays the development of drug resistance in pathogens and extends product lifespan. The scientific combination of two fungicides with different mechanisms of action can reduce the risk of resistance caused by continuous use of a single agent, delay the occurrence and development of drug resistance in blight pathogens, and extend the field life of the product.

[0033] 7. Wide range of applications, suitable for both conventional spraying and aerial spraying. The formulation has good flowability, fine particle size, and does not clog nozzles. It can be used for both manual backpack spraying and drone aerial spraying, making it convenient to use and meeting the needs of modern plant protection. Attached Figure Description

[0034] Figure 1 This is a diagram of the combined thermal storage of SP-SC2750 and SP-SC29. Figure 2 This is a graph showing the particle size changes before and after the combined thermal storage of SP-SC2750 and SP-SC29; Figure 3 This is a diagram of the skin formation on the bottle wall after combined heat storage of D-425 and SP-3468; Figure 4 This is a thermal storage wet sieve crystallization diagram of D-425 and SP-3468; Figure 5 This is a chart showing the suspension rate test results for the combination of Soprophor FL and IGEPAL BC / 10; Figure 6 This is a diagram of the combined heat storage and curing process of the Qingyu 2850 and Qingyu 3498D. Figure 7 This is a diagram showing the combined modified comb-type block polycarboxylate ULTRASURF 7023A and EO / PO block polyether ULTRASURF 8070 after thermal storage. Figure 8 This is a graph showing the effect of comparative example AGRILAN 700 and the present invention SP-480 on interfacial tension; Figure 9This is a graph showing the effect of comparative AGRILAN 700 and the SP-480 of this invention on dynamic surface tension. Detailed Implementation

[0035] The technical solutions and effects of the present invention will be further described below with reference to specific embodiments, but the present invention is not limited to the scope described in these embodiments. All percentages mentioned in the present invention are weight percentages.

[0036] In the raw materials or reagents used in the following embodiments of the present invention, wherein: Tetrazopyridine technical grade: produced by Japan Soda; Benzoylamidone: Produced by Guangkang Biochemical; ULTRASURF 7023A: Modified comb-type block polycarboxylate (Yijingfeng); ULTRASURF 8070: EO / PO block polyether (Yijingfeng); Soprophor FL: Polyarylphenyl ether phosphate amine salt (Solvay); IGEPAL BC / 10: Nonylphenol polyoxyethylene ether (Solvay); SP-SC2750: Polycarboxylate (Qingyu); SP-SC29: Alkylbenzene Sulfonate (Qingyu); SP-3468: Fatty alcohol polyoxyethylene ether (Qingyu); Qingyu 2850: Block polyether (Qingyu); Qingyu 3498D: Polycarboxylate (Qingyu); D-425: Sodium salt of alkyl naphthalene sulfonic acid condensation polymer (Nanjing Jierun). SAG 1572: Polydimethylsiloxane (Nanjing Jierun); PVA-1788: Polyvinyl alcohol (Inner Mongolia Shuangxin Environmental Protection Materials). Emulson STFS: Acrylic Emulsion (Ningbodi); AGRILAN 700: Acrylate polymer (AkzoNobel). GEROPON DA 1349: Acrylic polymer (Solvay); Filmer-17: Polyvinyl acetate emulsion (Dow Chemicals). BIT-20: 1,2-Benzisothiazolin-3-one (Wanhou Biotechnology); Ethylene glycol: purchased from Yuhua Industrial Co., Ltd. Magnesium aluminum silicate, attapulgite, and xanthan gum: purchased from Jiangsu Qingyu; Apart from the raw materials or reagents mentioned above, all other raw materials or reagents used in the following examples were obtained commercially.

[0037] I. Combined toxicity test Test pathogenic fungus: Phytophthora taroii ( Phytophthora colocasiae This bacterium is the pathogen that causes taro blight; Test reagents: Tetrazopyr technical grade, Benzoylamidol technical grade; Experimental method: The toxicity of the agent to the pathogenic fungus was determined by the growth rate method, referring to the agricultural industry standard NY / T1156.2006.

[0038] The drug was prepared into a stock solution, then mixed according to the predetermined proportions in Table 1. Five concentration gradients were prepared using an aqueous solution containing 1% Tween-80. These solutions were then added to PDA medium at 45-50℃, with a drug-to-medium volume ratio of 1:9. The mixture was thoroughly mixed and poured into sterile petri dishes. After cooling, a culture medium containing the toxic substance was formed. Each concentration was repeated three times. An aqueous solution containing 1% Tween-80 was used as a control. Subsequently, under aseptic conditions, pathogenic bacterial pellets were inoculated into the center of the drug-containing medium and incubated in a biochemical incubator at 25℃ in the dark for 7 days. The colony diameter was measured using the cross-cross method, and the growth inhibition rate of each drug treatment on the pathogen was calculated using the following formula. The EC50 of each treatment on the pathogen was also determined. 50 .

[0039]

[0040] Then, following Sun Yunpei's method, the EC values ​​of each treatment were measured. 50 Convert to Actual Toxicity Index (ATI); calculate the Theoretical Toxicity Index (TTI) based on the formulation ratio of the mixture, and calculate the Co-toxicity Coefficient (CTC) of the mixture according to the following formula. The results are shown in Table 1 below.

[0041]

[0042]

[0043] =

[0044]

[0045]

[0046] If the co-toxicity coefficient is greater than 120, it indicates a synergistic effect; if the co-toxicity coefficient is less than 80, it indicates an antagonistic effect; if the co-toxicity coefficient is between 80 and 120, it indicates an additive effect.

[0047] Table 1 Results of combined toxicity assay

[0048] Table 1 shows that tetrazolium pyridamole and benzimidazole have a synergistic effect in inhibiting Phytophthora tectorum. The co-toxicity coefficient is greater than 120 in the range of 10:1 to 1:10. In particular, the synergistic effect is very obvious in the range of 3:1 to 1:3, which is the preferred ratio range of the invention.

[0049] II. Screening of Additive Compatibility 1. Screening of wetting and dispersing agent combinations The type and dosage of wetting and dispersing agents were screened using a single-factor experimental method. The following suspension samples were prepared: 30% tetrazolium pyraclostrobin, 10% benzoyl sulfadiazine, and 1% magnesium silicate, as shown in Table 2 below, with the wetting and dispersing agent combinations and dosages, and the volume was increased to 100% with deionized water. The milling time was uniformly set to 30 minutes. Then, the suspension rate, thermal storage stability, and particle size variation of the samples were tested. The results are shown in Table 2 below.

[0050] The method for determining the suspension rate is as follows: Take 1 mL of the sample and add it to a beaker containing 50 mL of standard hard water (342 mg / L). Stir well with a glass rod, then rinse the entire sample into a 250 mL graduated cylinder with standard hard water and dilute to the mark. Stopper the cylinder and invert it 30 times within 1 minute, using the bottom of the cylinder as the axis. Open the stopper and place the cylinder vertically in a 30℃ constant temperature water bath for 30 minutes. Then, remove 9 / 10 (225 mL) of the contents using a pipette. When drawing the liquid, move the pipette along the inner wall of the graduated cylinder as the liquid level drops to avoid disturbing the lower sediment. Determine the content of the active ingredient in the sample and the 25 mL suspension remaining at the bottom of the graduated cylinder. The experiment is repeated in 3 replicates. Calculate the sample suspension rate using the following formula: Suspension rate = [(m1-m2) / m1] × (10 / 9) In the formula: m1 represents the mass of the effective component in the suspension sample; m2 represents the mass of the active ingredient remaining in the 25 mL suspension at the bottom of the graduated cylinder; The test method for thermal storage stability is as follows: the test solution is thermally stored at 54±2℃ for 14 days, and then the sedimentation and stratification are observed, and the particle size changes before and after thermal storage are compared.

[0051] Table 2 Screening of wetting and dispersing agent combinations

[0052] The screening results of wetting and dispersing agent combinations are shown in Table 2.

[0053] The combination of SP-SC2750 and SP-SC29 resulted in a low suspension rate, a large number of bubbles during sand milling, and increasing the amount of defoamer was ineffective. After heat storage, the product settled to the bottom, and severe water separation occurred. Figure 1The particle size increased by nearly 160%, with pre-thermal storage particle sizes D90 / D97 of 2.7 / 3.5 μm. Figure 2 Above); Particle size after thermal storage D90 / D97: 7.0 / 9.6μm ( Figure 2 Down).

[0054] The combination of D-425 and SP-3468 showed a low suspension rate, and after heat storage, a large amount of skin formed on the bottle wall. Figure 3 ); thermal storage wet sieving crystallization ( Figure 4 ).

[0055] The combination of Soprophor FL and IGEPAL BC / 10, when placed for 30 minutes for suspension testing, showed a large amount of flocculent matter in the graduated cylinder and obvious sediment at the bottom, indicating a low suspension rate. Figure 5 ).

[0056] The combination of Qingyu 2850 and Qingyu 3498D has a low suspension rate and tends to gel after heat storage. Figure 6 ).

[0057] The combination of the modified comb-type block polycarboxylate ULTRASURF 7023A and the EO / PO block polyether ULTRASURF 8070 of this invention exhibits superior performance compared to other combinations in terms of suspension rate, thermal storage stability, and other aspects. (The thermal storage stability is also superior.) Figure 7 ).

[0058] 2. Thickener Screening The wetting and dispersing agent combination obtained from the fixed screening was used to screen the thickener combination through single-factor experiments. The following suspension samples were prepared: tetrazolium pyraclostrobin 30%, benzyl benzoate 10%, ULTRASURF 7023A 3%, ULTRASURF 8070 2%, and the thickeners and their dosages listed in Table 3 below. The mixture was then made up to 100% with deionized water. The thermal storage stability of the samples was then tested. The results are shown in Table 3 below.

[0059] Table 3 Screening of Thickener Combinations

[0060] Table 3 shows that when magnesium aluminum silicate, attapulgite, and xanthan gum are used alone as thickeners, some water separation occurs after heat storage. The combination of attapulgite and xanthan gum as a thickener also exhibits water separation after heat storage. However, no water separation was observed after heat storage when using the combination of magnesium aluminum silicate and xanthan gum, or magnesium silicate as a thickener, which is the preferred method of this invention. Furthermore, compared to magnesium aluminum silicate and xanthan gum, magnesium silicate exhibits better resistance to microbial growth and improved milling efficiency at the same viscosity, making it the most preferred method of this invention.

[0061] 3. Moisturizer screening Humidifiers were screened through single-factor experiments. The following suspension samples were prepared: 30% tetrazolium pyridaben, 10% benzyl benzoate, 3% ULTRASURF 7023A, 2% ULTRASURF 8070, and 1% magnesium silicate. The humectants and their dosages listed in Table 4 below were added to a final volume of 100% with deionized water. Each suspension sample was diluted 1500 times and sprayed onto taro leaves, then allowed to air dry for 30 minutes. The film-forming properties of the agents on the plant leaves were then observed, and a rainwater washing test was conducted using a simulated rainwater washing device (rainfall: 10 mm / h, time: 10 min). The adhesion rate of the agents was calculated based on the weight difference of the leaves before and after washing. The results are shown in Table 4 below.

[0062] Table 4 Screening of Moisturizers

[0063] Table 4 shows that the polyvinyl acetate emulsion Filmer-17 has excellent film-forming properties and rain erosion resistance, and is the preferred choice of this invention.

[0064] 4. Screening of Enhanced Penetrants During the application of suspension concentrates, most plant stems and leaves often have a highly hydrophobic waxy layer that is difficult to wet with water. Furthermore, most chemical pesticides are poorly soluble or insoluble in water, requiring synergists to enhance their efficacy. This study screened synergistic penetrants through single-factor experiments. The following suspension concentrate samples were prepared: tetrazolium pyridaben 30%, benzyl acetamiprid 10%, ULTRASURF 7023A 3%, ULTRASURF 8070 2%, magnesium silicate 1%, Filmer-17 2.2%, and synergist 0.8%, to be made up to 100% with deionized water. Three synergists were selected: SP-408, AGRILAN 700, and GEROPON DA 1349. Each suspension concentrate sample was then diluted 1500 times to evaluate the interfacial tension of the pesticide solution on taro leaves. The results showed that SP-408 could better reduce the interfacial tension between the plant and the pesticide solution, enhance the wetting and spreading effect of the pesticide droplets, and allow the pesticide particles to adhere well even after being washed away by rainwater, thus maximizing their efficacy. This makes it the preferred formulation of this invention. The effects of the comparative example AGRILAN 700 and the SP-480 of this invention on interfacial tension are shown in [the table below]. Figure 8 (The left side shows AGRILAN 700, and the right side shows SP-480). The contact angle of SP-480 is significantly smaller than that of AGRILAN 700. The effect of the comparative examples AGRILAN 700 and the SP-480 of this invention on dynamic surface tension is shown in [reference needed]. Figure 9 (The green one at the top is the comparative example AGRILAN 700, and the red one at the bottom is the present invention SP-408).

[0065] III. Formulation Examples Formulation Example 1 Tetraazolylpyridine, 30% Benzoylamidone, 10% ULTRASURF 7023A, 3% ULTRASURF 8070, 2% Filmer-17, 2.2% SP-408, 0.8% Ethylene glycol, 5% BIT-20, 0.15% SAG 1572, 0.1% Magnesium silicate, 1.0% Add deionized water to bring the total to 100%.

[0066] The preparation method is as follows: (1) Weigh and measure the required materials; (2) Deionized water, dispersant ULTRASURF 7023A, emulsifying dispersant ULTRASURF 8070 and 1 / 3 of defoamer SAG 1572 were added to a shearing pot for shearing and dispersion; (3) Add tetrazolium pyraclostrobin technical and benzyme technical into a shearing pot, disperse them evenly, then add a mixture of thickener magnesium silicate and antifreeze ethylene glycol, shear for 30 minutes, add 1 / 3 of defoamer SAG 1572, and then grind in a sand mill. Control the particle size D90 to be less than 3.0 μm during sand milling. (4) After the sand milling is completed, the sample is sent for wet sieve testing. After the wet sieve is qualified, it is transferred to the mixing kettle, and the preservative BIT-20, humectant Filmer-17, synergist SP-408 and the remaining defoamer SAG 1572 are added. After shearing for 30 minutes, the suspension product containing tetrazolium pyridamole and benzyme is obtained.

[0067] Formulation Example 2 Tetrazolium pyridamole, 25% Benzoylamidone, 11% ULTRASURF 7023A, 4% ULTRASURF 8070, 2% Filmer-17, 3% SP-408, 0.6% Ethylene glycol, 5% BIT-20, 0.1% SAG 1572, 0.1% Magnesium aluminum silicate, 1.2% Xanthan gum, 0.1% Add deionized water to bring the total to 100%.

[0068] The preparation method is as follows: (1) Weigh and measure the required materials; (2) Deionized water, dispersant ULTRASURF 7023A, emulsifying dispersant ULTRASURF 8070 and 1 / 3 of defoamer SAG 1572 were added to a shearing pot for shearing and dispersion; (3) Add tetrazolium pyraclostrobin technical and benzyme technical into a shearing pot, disperse them evenly, then add a mixture of thickener magnesium aluminum silicate, 1 / 3 thickener xanthan gum, and antifreeze ethylene glycol. Shear for 30 minutes, add 1 / 3 defoamer SAG 1572, and then grind in a sand mill. Control the particle size D90 to be less than 3.0 μm during sand milling. (4) After the sand milling is completed, the sample is sent for wet sieve testing. After the wet sieve is qualified, it is transferred to the mixing kettle, and the preservative BIT-20, humectant Filmer-17, synergist SP-408, defoamer SAG 1572 and thickener xanthan gum are added. After shearing for 30 minutes, the suspension product containing tetrazolium pyridamole and benzyme is obtained.

[0069] Formulation Example 3 Tetraazolylpyridine, 32% Benzoylamidone, 8% ULTRASURF 7023A, 3% ULTRASURF 8070, 3% Filmer-17, 2% SP-408, 1% Ethylene glycol, 5% BIT-20, 0.2% SAG 1572, 0.1% Magnesium silicate, 0.9% Add deionized water to bring the total to 100%.

[0070] The preparation method is the same as that of Formulation Example 1.

[0071] Comparative Example 1 Tetraazolylpyridine, 30% Benzoylamidone, 10% SP-SC2750, 3% SP-SC29, 2% PVA-1788, 2.2% SP-408, 0.8% Ethylene glycol, 5% BIT-20, 0.15% SAG 1572, 0.1% Magnesium silicate, 1.0% Add deionized water to bring the total to 100%.

[0072] The preparation method is the same as that of Formulation Example 1.

[0073] Comparative Example 2 Tetraazolylpyridine, 30% Benzoylamidone, 10% Qingyu 2850, 3% 3498D, 2% Filmer-17, 2.2% SP-408, 0.8% Ethylene glycol, 5% BIT-20, 0.15% SAG 1572, 0.1% Attapulgite, 1.2% Xanthan gum, 0.2% Add deionized water to bring the total to 100%.

[0074] The preparation method is the same as in formulation example 2.

[0075] Then, the suspension rate and thermal storage stability (54℃, 14 days) of the above preparations were measured. The results are shown in Table 5 below.

[0076] Table 5. Measurement Results

[0077] The results showed that formulations 1-3 of the present invention were superior to comparative examples 1-2 in terms of suspension rate and thermal storage stability. Among them, formulation 1 showed the most outstanding effect and was the preferred formulation of the present invention.

[0078] IV. Field Trials Test crop: Taro; Target disease for prevention and control: Taro blight; Test reagents: Formulation Example 1 of the present invention; 30% tetrazolium pyridamole suspension, 10% benzoylmide suspension; Experimental Design: Fields with sufficient natural disease incidence were selected. Treatment began at the initial stage of disease development, with two applications administered 7 days apart. The experimental agent was Formulation Example 1 of this invention, and the control agents were 30% tetrazolium pyraclostrobin suspension and 10% benzyme-methyl suspension. An equal volume of water was used as a blank control. The spray volume for each treatment was controlled at 50 L / mu. Disease control status was assessed on days 7 and 14 after the last application. Each treatment was replicated three times. The results are shown in Table 6 below.

[0079] Table 6 Field Trial Results

[0080] The results showed that the field efficacy of formulation 1 of the present invention was superior to that of the two single agents when diluted 1500 times and 2000 times.

[0081] The above embodiments are merely exemplary implementations used to illustrate the present invention, and the present invention is not limited thereto. Those skilled in the art can make various improvements and modifications without departing from the essence of the present invention, and these improvements and modifications also fall within the protection scope of the present invention.

Claims

1. A suspension containing tetrazolium pyraclostrobin and benzyl benzoate, characterized in that, The suspending agent consists of the following components in weight percentages. composition: Tetraazolylpyridinium 20-40%, Benzyl sulfadiazine 5-15%, Dispersant 2-7%, Emulsifying dispersant 1-5%, Moisturizer 1-4%, Synergist 0.4-2%, Antifreeze 3-7%, Preservatives 0-0.2%, Defoamer 0.05-0.2%, Thickener 0.5-2%, Add deionized water to bring the total to 100%.

2. The suspending agent according to claim 1, characterized in that, The weight percentage of each component is as follows: Tetraazolylpyridine 25-35%, Benzyl sulfadiazine 8-13%, Dispersant 3-5%, Emulsifying dispersant 2-4%, Moisturizer 2-3%, Synergist 0.5-1%, Antifreeze 4-6%, Preservative 0.1-0.2%, Defoamer 0.08-0.12%, Thickener 0.8-1.5%, Add deionized water to bring the total to 100%.

3. The suspending agent according to claim 1 or 2, characterized in that, The weight ratio of tetrazolium pyraclostrobin to benzyl benzoyl amine is 10:1 to 1:

10.

4. The suspending agent according to claim 1 or 2, characterized in that, The dispersant is a modified comb-type block polycarboxylate.

5. The suspending agent according to claim 1 or 2, characterized in that, The emulsifying dispersant is an EO / PO block polyether.

6. The suspending agent according to claim 1 or 2, characterized in that, The humectant is polyvinyl acetate.

7. The suspending agent according to claim 1 or 2, characterized in that, The synergist is a polyether-modified trisiloxane.

8. The suspending agent according to claim 1 or 2, characterized in that, The thickener is one or more of sodium carboxymethyl cellulose, magnesium aluminum silicate, sodium alginate, xanthan gum, and magnesium silicate.

9. The suspending agent according to claim 1 or 2, characterized in that, The antifreeze is selected from one or more of ethylene glycol and propylene glycol; The preservative is selected from one or two of BIT and sodium benzoate; The defoamer is selected from one or more of n-octanol, isobutyl phosphate, and polydimethylsiloxane.

10. A method for preparing a suspension containing tetrazolium pyraclostrobin and benzyl benzoate as described in any one of claims 1-9, characterized in that, Includes the following steps: (1) Weigh and measure the required materials; (2) Add deionized water, dispersant, emulsifying dispersant and 1 / 3 of the defoamer into the shearing pot for shearing and dispersion; (3) Add tetrazolium pyraclostrobin technical and benzylamane technical into a shearing pot, disperse them evenly, then add a mixture of antifreeze and thickener, shear for 20-40 minutes, add 1 / 3 of the defoamer, and then grind in a sand mill. During sand milling, control the particle size D90 to be less than 3.0 μm. (4) After the sand milling is completed, the sample is sent for wet sieve testing. After the wet sieve is qualified, it is transferred to the mixing kettle, and preservative, humectant, synergist, residual defoamer and optional residual thickener are added. After shearing for 20-40 minutes, the product is obtained.

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