A spring thunder mycin and quinoline copper compound nano-suspension and a preparation method thereof

Abstract

The present application relates to the technical field of suspending agent, and proposes a kind of kasugamycin and quinoline copper compound nano-suspension and its preparation method.A kind of kasugamycin and quinoline copper compound nano-suspension is composed of the following raw materials by weight percentage: kasugamycin technical 2.0-6.0%, quinoline copper technical 30.0-34.0%, wetting dispersant 7.0-10.0%, stabilizer 2.0-3.5%, thickening agent 0.3-0.7%, antifreeze 3.0-5.0%, defoaming agent 0.1-0.3%, penetrant 0.5-1.5%, and the balance is water;The sum of the weight percentage of kasugamycin technical and quinoline copper technical is 36.0%.Through the above technical scheme, the problem that the suspension and stability of the suspending agent in the related art need to be improved is solved.

Description

Technical Field

[0001] This invention relates to the field of suspension technology, specifically to a nanoscale suspension composed of kasugamycin and quinoline copper and its preparation method. Background Technology

[0002] Kasugamycin is a systemic agricultural antibiotic with excellent therapeutic effects on bacterial diseases of crops (such as bacterial angular leaf spot, soft rot, and canker). Quinoline copper, on the other hand, is a broad-spectrum protective fungicide belonging to the organocopper class. It can form a protective antibacterial film on the crop surface, possessing both contact and bacteriostatic effects, and has good control efficacy against both fungi and bacteria. The combination of the two can achieve synergistic effects of protection and treatment, broaden the fungicidal spectrum, and delay the development of drug resistance in pathogens. It has now become the mainstream combination scheme for the prevention and control of various diseases in agricultural production.

[0003] In the prior art, patent application No. 202311580689.5 discloses a suspension containing kasugamycin and quinoline copper. Although its active ingredients are kasugamycin and quinoline copper, and it also has the technical effects of low viscosity and low thermal decomposition rate, its active ingredient content range is wide. Moreover, when the proportion of quinoline copper is high and the density is high, kasugamycin still has the problem of easy degradation. Ultimately, the suspension and stability of the suspension still need to be improved.

[0004] Therefore, developing a suspension concentrate combining kasugamycin and quinoline copper, which possesses both good suspension properties and stability, is of great significance for improving its practical application in the agricultural field. Summary of the Invention

[0005] To address the above technical problems, this invention provides a nanoscale suspension agent composed of kasugamycin and quinoline copper, and its preparation method. The nanoscale suspension agent provided by this invention uses kasugamycin and quinoline copper as active ingredients, with a fixed total content of 36.0%. Combined with specific wetting and dispersing agents, stabilizers, thickeners, antifreeze agents, defoamers, and penetrants, a low-foaming, high-susceptibility, and highly stable kasugamycin•quinoline copper nanoscale aqueous suspension agent can be prepared, solving the problems of poor suspension and poor stability of existing suspension agents.

[0006] The specific technical solution of the present invention is as follows: According to one aspect of the present invention, a nanoscale suspension composed of kasugamycin and quinoline copper is provided, comprising the following raw materials in weight percentages: Kasugamycin technical grade 2.0%~6.0%, quinoline copper technical grade 30.0%~34.0%, wetting and dispersing agent 7.0%~10.0%, stabilizer 2.0%~3.5%, thickener 0.3%~0.7%, antifreeze 3.0%~5.0%, defoamer 0.1%~0.3%, penetrant 0.5%~1.5%, balance being water; The sum of the weight percentages of the kasugamycin technical and the quinoline copper technical is 36.0%.

[0007] In the above technical solution, the weight percentage of the kasugamycin technical is 3.0%, and the weight percentage of the quinoline copper technical is 33.0%.

[0008] In the above technical solution, the wetting and dispersing agent includes polycarboxylate dispersant, fatty alcohol polyoxyethylene ether phosphate and sodium salt of alkyl naphthalene sulfonic acid condensate.

[0009] In the above technical solution, the weight ratio of the polycarboxylate dispersant, fatty alcohol polyoxyethylene ether phosphate and alkyl naphthalene sulfonic acid condensate sodium salt is 2:2~3:3~4, preferably 2:3:3.

[0010] In the above technical solution, the stabilizer includes sodium bisulfite and disodium ethylenediaminetetraacetate; The weight ratio of sodium bisulfite to disodium ethylenediaminetetraacetate is 1 to 1.5:1, preferably 1:1.

[0011] In the above technical solution, the thickener includes xanthan gum and magnesium aluminum silicate; The weight ratio of xanthan gum to magnesium aluminum silicate is 1:1.5~2, preferably 1:2.

[0012] In the above technical solution, the penetrant is an organosilicon penetrant; the organosilicon penetrant includes polyether-modified trisiloxane and ethoxy-modified trisiloxane.

[0013] In the above technical solution, the weight ratio of the polyether-modified trisiloxane and the ethoxy-modified trisiloxane is 1:1 to 1.5, preferably 1:1.

[0014] In the above technical solution, the antifreeze includes propylene glycol; The defoamer includes silicone defoamers.

[0015] According to another aspect of the present invention, the present invention also provides a method for preparing the above-mentioned nanoscale suspension composed of kasugamycin and quinoline copper, comprising the following steps: S1. Add the kasugamycin technical, quinoline copper technical, wetting and dispersing agent, antifreeze agent, and defoamer to water, and shear to obtain a crude suspension; S2. Grind the coarse suspension, stir once, add the thickener, the stabilizer and the penetrant, stir a second time to obtain the swelling solution; S3. Adjust the pH of the swelling solution to 4-7, filter, and obtain the nanoscale suspension.

[0016] In the above technical solution, during step S1, the cutting time is 30~45 minutes.

[0017] In the above technical solution, in step S2, during the grinding process, the temperature of the coarse suspension is ≤40℃, the grinding time is 60~100min, and the grinding is carried out until the particle size D97 of the coarse suspension is in the nanometer range.

[0018] In the above technical solution, in step S2, the stirring speed is 50~100 rpm and the stirring time is 10~20 min during each stirring.

[0019] In the above technical solution, during step S2, the stirring speed is 50~100 rpm and the stirring time is 20~30 min.

[0020] This invention provides a nanoscale suspension with kasugamycin and quinoline copper as active ingredients. The combination of the two can achieve synergistic protection and treatment, broaden the bactericidal spectrum, and delay the development of bacterial drug resistance. By adjusting the content ratio of the two, the total content of the active ingredients is fixed at 36.0%, which has the advantages of accurate measurement and convenient use. At the same time, in this system, the weight percentage of kasugamycin technical is 2.0%~6.0% and that of quinoline copper technical is 30.0%~34.0%. In this system, the high proportion and high density of quinoline copper, along with the copper ions released by the high content of quinoline copper, can easily catalyze the degradation of kasugamycin. Conventional adjuvants are prone to particle sedimentation, agglomeration, and water separation, and cannot maintain the long-term stability of the suspension. In this invention, the nano-scale suspension uses kasugamycin and quinoline copper as active ingredients, with a fixed total content of 36.0%. At the same time, specific wetting and dispersing agents, stabilizers, thickeners, antifreeze agents, defoamers, and penetrants are used, and the dosage of each auxiliary agent is adjusted. With the reasonable combination of each component, a low-foaming, high-suspension, and highly stable kasugamycin·quinoline copper nano-scale aqueous suspension can be prepared. Detailed Implementation

[0021] To make the objectives, technical solutions, and advantages of this invention more apparent, the invention is described in detail below. It should be understood that the invention is not limited to the description herein.

[0022] Kasugamycin technical grade The kasugamycin technical material used in this invention is a known kasugamycin technical material that can be used in suspension concentrates. Kasugamycin is a systemic agricultural antibiotic that can interfere with the esterase system of amino acid metabolism in pathogens, thereby affecting protein synthesis, inhibiting the growth and reproduction of pathogens, and has excellent therapeutic effects on bacterial diseases of crops, such as bacterial angular leaf spot, soft rot, and canker.

[0023] Quinoline copper technical grade The quinoline copper technical material used in this invention is a known quinoline copper technical material that can be used in suspension concentrates. Quinoline copper is a broad-spectrum protective fungicide of the organocopper class. Its fungicidal mechanism mainly involves releasing copper ions and exchanging cations with the surface of pathogen cell membranes, causing the proteins on the pathogen cell membranes to coagulate. Simultaneously, some copper ions penetrate into the pathogen cells, binding with certain enzymes and affecting their activity, thereby achieving the purpose of fungicide. In this invention, quinoline copper can form an antibacterial protective film on the crop surface, possessing both contact killing and antibacterial effects, and exhibiting good control efficacy against both fungi and bacteria.

[0024] In this invention, the combined use of kasugamycin and quinoline copper can achieve synergistic protection and treatment, broaden the bactericidal spectrum, and delay the development of bacterial drug resistance.

[0025] wetting and dispersing agents The wetting and dispersing agents used in this invention are known in the art for use in suspensions. These agents include polycarboxylate dispersants, fatty alcohol polyoxyethylene ether phosphates, and sodium alkyl naphthalene sulfonic acid condensates. The polycarboxylate dispersant can be, for example, SP-NS5348 or SP-2836, preferably SP-NS5348. SP-NS5348 is a high-molecular-weight polycarboxylate dispersant formed by copolymerization of unsaturated monomers, possessing long carbon chains and numerous active adsorption sites, which helps to form a large adsorption structure on the surface of suspension particles, enhancing the dispersion effect. The fatty alcohol polyoxyethylene ether phosphate can both adsorb onto the surface of the active pharmaceutical ingredient particles and interact with water, enhancing the hydrophilicity and dispersion stability of the particles. The sodium alkyl naphthalene sulfonic acid condensate belongs to the naphthalene sulfonate surfactant class, and can be, for example, SP-2825L. In this invention, the sodium alkyl naphthalene sulfonic acid condensate has good water solubility and electrostatic repulsion, effectively dispersing solid particles and preventing agglomeration.

[0026] In this invention, the wetting and dispersing agent includes a polycarboxylate dispersant, a fatty alcohol polyoxyethylene ether phosphate, and a sodium alkyl naphthalene sulfonic acid condensate. By using these three in combination, the surface tension of the suspension system can be effectively reduced, preventing particle agglomeration in the system. It has good anti-flocculation effect and anti-stratification ability in high ionic systems, and ultimately effectively improves the suspension properties and stability of the suspension.

[0027] In this invention, the content ratio of polycarboxylate dispersant, fatty alcohol polyoxyethylene ether phosphate, and sodium alkyl naphthalene sulfonic acid condensate is optimized. The weight ratio of polycarboxylate dispersant, fatty alcohol polyoxyethylene ether phosphate, and sodium alkyl naphthalene sulfonic acid condensate is 2:2~3:3~4, for example, 2:3:3, 2:2:4, 2:2.5:3.5, preferably 2:3:3. In this invention, when the weight ratio of polycarboxylate dispersant, fatty alcohol polyoxyethylene ether phosphate, and sodium alkyl naphthalene sulfonic acid condensate is 2:3:3, the suspending properties of the suspending agent can be further improved.

[0028] stabilizer The stabilizers used in this invention are known in the art for use in suspensions, and this invention is not limited to the stabilizers listed below. For example, the stabilizers may be sodium bisulfite and disodium ethylenediaminetetraacetate (EDTA-2Na). In the prior art, copper ions released from high-content quinoline copper readily catalyze the degradation of kasugamycin. However, the prior art often uses a single stabilizer, which cannot effectively inhibit the degradation of the active component, and the active component decays relatively quickly after heat storage. This invention uses sodium bisulfite and disodium EDTA-2Na as stabilizers. Sodium bisulfite effectively inhibits the degradation of kasugamycin, while disodium EDTA-2Na effectively chelates copper ions. Through the rational combined use of sodium bisulfite and disodium EDTA-2Na, the stability of the suspension can be effectively improved.

[0029] In this invention, the weight ratio of sodium bisulfite to disodium ethylenediaminetetraacetate is 1 to 1.5:1, for example, it can be 1:1, 1.2:1, 1.3:1, 1.4:1, or 1.5:1, preferably 1:1, 1.5:1, and more preferably 1:1. In this invention, when the weight ratio of sodium bisulfite to disodium ethylenediaminetetraacetate is 1:1, the stability of the suspending agent can be further improved, and compared with a single stabilizer, the degradation rate of the effective heat-storage component can be reduced by more than 60%.

[0030] Thickener The thickener used in this invention is a known thickener for use in suspensions, and this invention is not limited to the thickeners listed below. For example, the thickener may be xanthan gum and magnesium aluminum silicate. In this invention, xanthan gum and magnesium aluminum silicate are selected as thickeners. By using both together, the viscosity of the suspension system can be kept at a moderate level, slowing down the sedimentation rate of the active ingredient and ensuring the suspension's suspendability. Simultaneously, the combined use of xanthan gum and magnesium aluminum silicate can effectively reduce the heat storage water separation rate of the suspension, thus improving its stability.

[0031] In this invention, the content ratio of xanthan gum and magnesium aluminum silicate is optimized so that the weight ratio of xanthan gum to magnesium aluminum silicate is 1:1.5~2, for example, it can be 1:1.5, 1:1.6, 1:1.7, 1:1.8, 1:1.9, 1:2, preferably 1:1.5, 1:2, and more preferably 1:2. In this invention, when the weight ratio of xanthan gum to magnesium aluminum silicate is 1:2, the stability of the suspending agent can be further improved, and its heat storage water separation rate can be controlled within 2.5%. However, when the weight ratio of xanthan gum to magnesium aluminum silicate is outside the range of 1:1.5~2, the heat storage water separation rate of the suspending agent is higher, and the stability is relatively poor.

[0032] antifreeze The antifreeze used in this invention is a known antifreeze agent for use with suspensions, and this invention is not limited to the antifreeze agents listed below. For example, the antifreeze agent can be ethylene glycol, propylene glycol, or glycerol, preferably propylene glycol. In this invention, the addition of the antifreeze agent can effectively lower the freezing point of the suspension, preventing it from freezing in low-temperature environments and ensuring its stability.

[0033] Defoamer The defoamer used in this invention is a known defoamer for use in suspension concentrates, and this invention is not limited to the defoamers listed below. As an example, the defoamer can be an organosilicone defoamer. During the production and use of suspension concentrates, a large amount of foam is easily generated due to stirring and other operations. Excessive foam can affect the production efficiency of the suspension concentrate. During use, foam may lead to uneven spraying, affecting the distribution of the pesticide on the plant surface and reducing the control effect. In this invention, the addition of an organosilicone defoamer can reduce the surface tension of the foam, quickly eliminate foam, and ensure the smooth progress of the suspension concentrate production process and its effectiveness.

[0034] Penetrant The penetrant used in this invention is a penetrant known in the art for use in suspensions, and this invention is not limited to the penetrants listed below. As an example, the penetrant can be an organosilicon penetrant. The organosilicon penetrants in this invention include polyether-modified trisiloxanes and ethoxy-modified trisiloxanes. The ethoxy-modified trisiloxane, model IOTA2000, is a modified organosilicon surfactant with low surface tension and good spreading and penetrating properties. The combined use of polyether-modified and ethoxy-modified trisiloxanes effectively enhances the wettability and adhesion of the suspension on plant surfaces, improving the suspension's resistance to rainwater erosion and ultimately enhancing its stability.

[0035] In this invention, the content ratio of polyether-modified trisiloxane and ethoxy-modified trisiloxane is optimized so that the weight ratio of polyether-modified trisiloxane to ethoxy-modified trisiloxane is 1:1 to 1.5, for example, it can be 1:1, 1:1.1, 1:1.2, 1:1.3, 1:1.4, 1:1.5, preferably 1:1.5 or 1:1, and more preferably 1:1. In this invention, when the weight ratio of polyether-modified trisiloxane to ethoxy-modified trisiloxane is 1:1, the stability of the suspending agent can be further improved, thereby increasing its adhesion to the leaves.

[0036] A nanoscale suspension agent composed of kasugamycin and quinoline copper. The nanoscale suspension concentrate composed of kasugamycin and quinoline copper is composed of the following raw materials by weight percentage: The composition includes 2.0%–6.0% kasugamycin technical, 30.0%–34.0% quinoline copper technical, 7.0%–10.0% wetting and dispersing agent, 2.0%–3.5% stabilizer, 0.3%–0.7% thickener, 3.0%–5.0% antifreeze, 0.1%–0.3% defoamer, 0.5%–1.5% penetrant, and the balance being water; the total weight percentage of kasugamycin technical and quinoline copper technical is 36.0%.

[0037] The nanoscale suspension concentrate composed of kasugamycin and quinoline copper is composed of the following raw materials by weight percentage: The composition includes 3% kasugamycin technical grade, 33% quinoline copper technical grade, 7.0%~10.0% wetting and dispersing agent, 2.0%~3.5% stabilizer, 0.3%~0.7% thickener, 3.0%~5.0% antifreeze, 0.1%~0.3% defoamer, 0.5%~1.5% penetrant, and the balance being water.

[0038] A method for preparing a nanoscale suspension agent composed of kasugamycin and quinoline copper includes the following steps: S1. Add kasugamycin technical, quinoline copper technical, wetting and dispersing agent, antifreeze agent, and defoamer to water, and shear to obtain a crude suspension; S2. Grind the coarse suspension, stir once, add thickener, stabilizer and penetrant, stir a second time to obtain swollen solution; S3. Adjust the pH of the swelling solution to 4-7, filter, and obtain the nanoscale suspension.

[0039] In this invention, the preparation method of the nanoscale suspension of kasugamycin and quinoline copper is as follows: In step S1, the shearing time is 30-45 min; in step S2, the temperature of the coarse suspension is ≤40℃, the grinding time is 60-100 min, and the coarse suspension is ground until the particle size D97 is in the nanoscale; in step S2, the stirring speed is 50-100 rpm and the stirring time is 10-20 min during the first stirring; in step S2, the stirring speed is 50-100 rpm and the stirring time is 20-30 min during the second stirring; in step S3, when adjusting the pH value of the swelling solution to 4-7, sodium citrate is used for adjustment.

[0040] To further illustrate the present invention, the following examples will provide a detailed description. The raw materials used in the following examples and comparative examples of the present invention are all commercially available products. Specifically, the polycarboxylate dispersant, model SP-NS5348, was purchased from Jiangsu Qingyu Chemical Technology Co., Ltd.; the fatty alcohol polyoxyethylene ether phosphate, with an effective ingredient content of 98%; the alkyl naphthalene sulfonic acid condensate sodium salt, model SP-2825L, was purchased from Jiangsu Qingyu Chemical Technology Co., Ltd.; the organosilicon defoamer, model TEGOFOAMEX 825; the polyether-modified trisiloxane, model HY-250; and the ethoxylated trisiloxane, model IOTA2000, were purchased from Anhui Aiyota Silicone Oil Co., Ltd.

[0041] Example 1 A nanoscale suspension agent composed of kasugamycin and quinoline copper, comprising the following raw materials by weight percentage: The composition of the product is as follows: 3.0% kasugamycin technical grade, 33.0% quinoline copper technical grade, 8.5% wetting and dispersing agent, 2.5% stabilizer, 0.5% thickener, 4.0% propylene glycol, 0.2% silicone defoamer, 1.0% silicone penetrant, and the remainder is deionized water. The wetting and dispersing agent is composed of a polycarboxylate dispersant, fatty alcohol polyoxyethylene ether phosphate, and sodium salt of alkyl naphthalene sulfonic acid condensate in a weight ratio of 2:3:3. The stabilizer consists of sodium bisulfite and disodium ethylenediaminetetraacetate in a weight ratio of 1:1; The thickener consists of xanthan gum and magnesium aluminum silicate in a weight ratio of 1:2; The organosilicon penetrant is composed of polyether-modified trisiloxane and ethoxy-modified trisiloxane in a weight ratio of 1:1.

[0042] A method for preparing a nanoscale suspension agent composed of kasugamycin and quinoline copper includes the following steps: S1. Add kasugamycin technical, quinoline copper technical, wetting and dispersing agent, propylene glycol, and organosilicon defoamer to deionized water, and shear for 40 min to obtain a crude suspension; S2. Pump the coarse suspension into a nano mill and grind it at 40°C for 80 minutes to stabilize the particle size D97 of the coarse suspension at the nano level. Stir at 80 rpm for 15 minutes, add thickener, stabilizer and organosilicon penetrant, and continue stirring at 80 rpm for 25 minutes to obtain a swollen solution. S3. The pH of the swelling solution was adjusted to 6 using sodium citrate, and then filtered through a 200-mesh nylon filter to obtain a nano-sized suspension.

[0043] Example 2 A nanoscale suspension agent composed of kasugamycin and quinoline copper, comprising the following raw materials by weight percentage: Kasugamycin technical grade 2.0%, Quinoline copper technical grade 34.0%, Wetting and dispersing agent 7.0%, Stabilizer 2.0%, Thickener 0.3%, Propylene glycol 3.0%, Organosilicone defoamer 0.1%, Organosilicone penetrant 0.5%, and the balance is deionized water; The wetting and dispersing agent is composed of a polycarboxylate dispersant, fatty alcohol polyoxyethylene ether phosphate, and sodium salt of alkyl naphthalene sulfonic acid condensate in a weight ratio of 2:3:3. The stabilizer consists of sodium bisulfite and disodium ethylenediaminetetraacetate in a weight ratio of 1:1; The thickener consists of xanthan gum and magnesium aluminum silicate in a weight ratio of 1:2; The organosilicon penetrant is composed of polyether-modified trisiloxane and ethoxy-modified trisiloxane in a weight ratio of 1:1.

[0044] A method for preparing a nanoscale suspension agent composed of kasugamycin and quinoline copper includes the following steps: S1. Add kasugamycin technical, quinoline copper technical, wetting and dispersing agent, propylene glycol, and organosilicon defoamer to deionized water, and shear for 30 min to obtain a crude suspension; S2. Pump the coarse suspension into a nano-sand mill and grind it at 38°C for 60 minutes to stabilize the particle size D97 of the coarse suspension at the nanoscale. Stir at 50 rpm for 20 minutes, add thickener, stabilizer and organosilicon penetrant, and continue stirring at 50 rpm for 30 minutes to obtain a swollen solution. S3. The pH of the swelling solution was adjusted to 4 using sodium citrate, and then filtered through a 200-mesh nylon filter to obtain a nano-sized suspension.

[0045] Example 3 A nanoscale suspension agent composed of kasugamycin and quinoline copper, comprising the following raw materials by weight percentage: The composition includes: 6.0% kasugamycin technical grade, 30.0% quinoline copper technical grade, 10.0% wetting and dispersing agent, 3.5% stabilizer, 0.7% thickener, 5.0% propylene glycol, 0.3% silicone defoamer, 1.5% silicone penetrant, and the remainder is deionized water. The wetting and dispersing agent is composed of a polycarboxylate dispersant, fatty alcohol polyoxyethylene ether phosphate, and sodium salt of alkyl naphthalene sulfonic acid condensate in a weight ratio of 2:3:3. The stabilizer consists of sodium bisulfite and disodium ethylenediaminetetraacetate in a weight ratio of 1:1; The thickener consists of xanthan gum and magnesium aluminum silicate in a weight ratio of 1:2; The organosilicon penetrant is composed of polyether-modified trisiloxane and ethoxy-modified trisiloxane in a weight ratio of 1:1.

[0046] A method for preparing a nanoscale suspension agent composed of kasugamycin and quinoline copper includes the following steps: S1. Add kasugamycin technical, quinoline copper technical, wetting and dispersing agent, propylene glycol, and organosilicon defoamer to deionized water, and shear for 45 min to obtain a crude suspension; S2. Pump the coarse suspension into a nano-sand mill and grind it at 40°C for 100 min to stabilize the particle size D97 of the coarse suspension at the nanoscale. Stir at 100 rpm for 10 min, add thickener, stabilizer and organosilicon penetrant, and continue stirring at 100 rpm for 20 min to obtain the swelling solution. S3. The pH of the swelling solution was adjusted to 7 using sodium citrate, and then filtered through a 200-mesh nylon filter to obtain a nano-sized suspension.

[0047] Example 4 A nanoscale suspension agent composed of kasugamycin and quinoline copper, comprising the following raw materials by weight percentage: The composition of the product is as follows: 3.0% kasugamycin technical grade, 33.0% quinoline copper technical grade, 8.5% wetting and dispersing agent, 2.5% stabilizer, 0.5% thickener, 4.0% propylene glycol, 0.2% silicone defoamer, 1.0% silicone penetrant, and the remainder is deionized water. The wetting and dispersing agent is composed of polycarboxylate dispersant, fatty alcohol polyoxyethylene ether phosphate and sodium salt of alkyl naphthalene sulfonic acid condensate in a weight ratio of 2:2:4. The stabilizer consists of sodium bisulfite and disodium ethylenediaminetetraacetate in a weight ratio of 1.5:1; The thickener consists of xanthan gum and magnesium aluminum silicate in a weight ratio of 1:1.5; The organosilicon penetrant is composed of polyether-modified trisiloxane and ethoxylated trisiloxane in a weight ratio of 1:1.5.

[0048] A method for preparing a nanoscale suspension agent composed of kasugamycin and quinoline copper includes the following steps: S1. Add kasugamycin technical, quinoline copper technical, wetting and dispersing agent, propylene glycol, and organosilicon defoamer to deionized water, and shear for 40 min to obtain a crude suspension; S2. Pump the coarse suspension into a nano mill and grind it at 40°C for 80 minutes to stabilize the particle size D97 of the coarse suspension at the nano level. Stir at 80 rpm for 15 minutes, add thickener, stabilizer and organosilicon penetrant, and continue stirring at 80 rpm for 25 minutes to obtain a swollen solution. S3. The pH of the swelling solution was adjusted to 6 using sodium citrate, and then filtered through a 200-mesh nylon filter to obtain a nano-sized suspension.

[0049] Example 5 A nanoscale suspension agent composed of kasugamycin and quinoline copper, comprising the following raw materials by weight percentage: The composition of the product is as follows: 3.0% kasugamycin technical grade, 33.0% quinoline copper technical grade, 8.5% wetting and dispersing agent, 2.5% stabilizer, 0.5% thickener, 4.0% propylene glycol, 0.2% silicone defoamer, 1.0% silicone penetrant, and the remainder is deionized water. Among them, the wetting and dispersing agent consists only of polycarboxylate dispersants; The stabilizer consists of sodium bisulfite and disodium ethylenediaminetetraacetate in a weight ratio of 1:1; The thickener consists of xanthan gum and magnesium aluminum silicate in a weight ratio of 1:2; The organosilicon penetrant is composed of polyether-modified trisiloxane and ethoxy-modified trisiloxane in a weight ratio of 1:1.

[0050] A method for preparing a nanoscale suspension agent composed of kasugamycin and quinoline copper includes the following steps: S1. Add kasugamycin technical, quinoline copper technical, wetting and dispersing agent, propylene glycol, and organosilicon defoamer to deionized water, and shear for 40 min to obtain a crude suspension; S2. Pump the coarse suspension into a nano mill and grind it at 40°C for 80 minutes to stabilize the particle size D97 of the coarse suspension at the nano level. Stir at 80 rpm for 15 minutes, add thickener, stabilizer and organosilicon penetrant, and continue stirring at 80 rpm for 25 minutes to obtain a swollen solution. S3. The pH of the swelling solution was adjusted to 6 using sodium citrate, and then filtered through a 200-mesh nylon filter to obtain a nano-sized suspension.

[0051] Example 6 A nanoscale suspension agent composed of kasugamycin and quinoline copper, comprising the following raw materials by weight percentage: The composition of the product is as follows: 3.0% kasugamycin technical grade, 33.0% quinoline copper technical grade, 8.5% wetting and dispersing agent, 2.5% stabilizer, 0.5% thickener, 4.0% propylene glycol, 0.2% silicone defoamer, 1.0% silicone penetrant, and the remainder is deionized water. The wetting and dispersing agent consists only of a polycarboxylate dispersant and a sodium alkyl naphthalene sulfonic acid condensate in a weight ratio of 1:1. The stabilizer consists of sodium bisulfite and disodium ethylenediaminetetraacetate in a weight ratio of 1:1; The thickener consists of xanthan gum and magnesium aluminum silicate in a weight ratio of 1:2; The organosilicon penetrant is composed of polyether-modified trisiloxane and ethoxy-modified trisiloxane in a weight ratio of 1:1.

[0052] A method for preparing a nanoscale suspension agent composed of kasugamycin and quinoline copper includes the following steps: S1. Add kasugamycin technical, quinoline copper technical, wetting and dispersing agent, propylene glycol, and organosilicon defoamer to deionized water, and shear for 40 min to obtain a crude suspension; S2. Pump the coarse suspension into a nano mill and grind it at 40°C for 80 minutes to stabilize the particle size D97 of the coarse suspension at the nano level. Stir at 80 rpm for 15 minutes, add thickener, stabilizer and organosilicon penetrant, and continue stirring at 80 rpm for 25 minutes to obtain a swollen solution. S3. The pH of the swelling solution was adjusted to 6 using sodium citrate, and then filtered through a 200-mesh nylon filter to obtain a nano-sized suspension.

[0053] Example 7 A nanoscale suspension agent composed of kasugamycin and quinoline copper, comprising the following raw materials by weight percentage: The composition of the product is as follows: 3.0% kasugamycin technical grade, 33.0% quinoline copper technical grade, 8.5% wetting and dispersing agent, 2.5% stabilizer, 0.5% thickener, 4.0% propylene glycol, 0.2% silicone defoamer, 1.0% silicone penetrant, and the remainder is deionized water. The wetting and dispersing agent consists only of fatty alcohol polyoxyethylene ether phosphate and sodium salt of alkyl naphthalene sulfonic acid condensate in a weight ratio of 1:1. The stabilizer consists of sodium bisulfite and disodium ethylenediaminetetraacetate in a weight ratio of 1:1; The thickener consists of xanthan gum and magnesium aluminum silicate in a weight ratio of 1:2; The organosilicon penetrant is composed of polyether-modified trisiloxane and ethoxy-modified trisiloxane in a weight ratio of 1:1.

[0054] A method for preparing a nanoscale suspension agent composed of kasugamycin and quinoline copper includes the following steps: S1. Add kasugamycin technical, quinoline copper technical, wetting and dispersing agent, propylene glycol, and organosilicon defoamer to deionized water, and shear for 40 min to obtain a crude suspension; S2. Pump the coarse suspension into a nano mill and grind it at 40°C for 80 minutes to stabilize the particle size D97 of the coarse suspension at the nano level. Stir at 80 rpm for 15 minutes, add thickener, stabilizer and organosilicon penetrant, and continue stirring at 80 rpm for 25 minutes to obtain a swollen solution. S3. The pH of the swelling solution was adjusted to 6 using sodium citrate, and then filtered through a 200-mesh nylon filter to obtain a nano-sized suspension.

[0055] Example 8 A nanoscale suspension agent composed of kasugamycin and quinoline copper, comprising the following raw materials by weight percentage: The composition of the product is as follows: 3.0% kasugamycin technical grade, 33.0% quinoline copper technical grade, 8.5% wetting and dispersing agent, 2.5% stabilizer, 0.5% thickener, 4.0% propylene glycol, 0.2% silicone defoamer, 1.0% silicone penetrant, and the remainder is deionized water. The wetting and dispersing agent consists only of a polycarboxylate dispersant and a fatty alcohol polyoxyethylene ether phosphate in a weight ratio of 1:1. The stabilizer consists of sodium bisulfite and disodium ethylenediaminetetraacetate in a weight ratio of 1:1; The thickener consists of xanthan gum and magnesium aluminum silicate in a weight ratio of 1:2; The organosilicon penetrant is composed of polyether-modified trisiloxane and ethoxy-modified trisiloxane in a weight ratio of 1:1.

[0056] A method for preparing a nanoscale suspension agent composed of kasugamycin and quinoline copper includes the following steps: S1. Add kasugamycin technical, quinoline copper technical, wetting and dispersing agent, propylene glycol, and organosilicon defoamer to deionized water, and shear for 40 min to obtain a crude suspension; S2. Pump the coarse suspension into a nano mill and grind it at 40°C for 80 minutes to stabilize the particle size D97 of the coarse suspension at the nano level. Stir at 80 rpm for 15 minutes, add thickener, stabilizer and organosilicon penetrant, and continue stirring at 80 rpm for 25 minutes to obtain a swollen solution. S3. The pH of the swelling solution was adjusted to 6 using sodium citrate, and then filtered through a 200-mesh nylon filter to obtain a nano-sized suspension.

[0057] Example 9 A nanoscale suspension agent composed of kasugamycin and quinoline copper, comprising the following raw materials by weight percentage: The composition of the product is as follows: 3.0% kasugamycin technical grade, 33.0% quinoline copper technical grade, 8.5% wetting and dispersing agent, 2.5% stabilizer, 0.5% thickener, 4.0% propylene glycol, 0.2% silicone defoamer, 1.0% silicone penetrant, and the remainder is deionized water. The wetting and dispersing agent is composed of a polycarboxylate dispersant, fatty alcohol polyoxyethylene ether phosphate, and sodium salt of alkyl naphthalene sulfonic acid condensate in a weight ratio of 2:3:3. The stabilizer consists of sodium bisulfite; The thickener consists of xanthan gum and magnesium aluminum silicate in a weight ratio of 1:2; The organosilicon penetrant is composed of polyether-modified trisiloxane and ethoxy-modified trisiloxane in a weight ratio of 1:1.

[0058] A method for preparing a nanoscale suspension agent composed of kasugamycin and quinoline copper includes the following steps: S1. Add kasugamycin technical, quinoline copper technical, wetting and dispersing agent, propylene glycol, and organosilicon defoamer to deionized water, and shear for 40 min to obtain a crude suspension; S2. Pump the coarse suspension into a nano mill and grind it at 40°C for 80 minutes to stabilize the particle size D97 of the coarse suspension at the nano level. Stir at 80 rpm for 15 minutes, add thickener, stabilizer and organosilicon penetrant, and continue stirring at 80 rpm for 25 minutes to obtain a swollen solution. S3. The pH of the swelling solution was adjusted to 6 using sodium citrate, and then filtered through a 200-mesh nylon filter to obtain a nano-sized suspension.

[0059] Example 10 A nanoscale suspension agent composed of kasugamycin and quinoline copper, comprising the following raw materials by weight percentage: The composition of the product is as follows: 3.0% kasugamycin technical grade, 33.0% quinoline copper technical grade, 8.5% wetting and dispersing agent, 2.5% stabilizer, 0.5% thickener, 4.0% propylene glycol, 0.2% silicone defoamer, 1.0% silicone penetrant, and the remainder is deionized water. The wetting and dispersing agent is composed of a polycarboxylate dispersant, fatty alcohol polyoxyethylene ether phosphate, and sodium salt of alkyl naphthalene sulfonic acid condensate in a weight ratio of 2:3:3. The stabilizer consists of sodium bisulfite and disodium ethylenediaminetetraacetate in a weight ratio of 2:1; The thickener consists of xanthan gum and magnesium aluminum silicate in a weight ratio of 1:2; The organosilicon penetrant is composed of polyether-modified trisiloxane and ethoxy-modified trisiloxane in a weight ratio of 1:1.

[0060] A method for preparing a nanoscale suspension agent composed of kasugamycin and quinoline copper includes the following steps: S1. Add kasugamycin technical, quinoline copper technical, wetting and dispersing agent, propylene glycol, and organosilicon defoamer to deionized water, and shear for 40 min to obtain a crude suspension; S2. Pump the coarse suspension into a nano mill and grind it at 40°C for 80 minutes to stabilize the particle size D97 of the coarse suspension at the nano level. Stir at 80 rpm for 15 minutes, add thickener, stabilizer and organosilicon penetrant, and continue stirring at 80 rpm for 25 minutes to obtain a swollen solution. S3. The pH of the swelling solution was adjusted to 6 using sodium citrate, and then filtered through a 200-mesh nylon filter to obtain a nano-sized suspension.

[0061] Example 11 A nanoscale suspension agent composed of kasugamycin and quinoline copper, comprising the following raw materials by weight percentage: The composition of the product is as follows: 3.0% kasugamycin technical grade, 33.0% quinoline copper technical grade, 8.5% wetting and dispersing agent, 2.5% stabilizer, 0.5% thickener, 4.0% propylene glycol, 0.2% silicone defoamer, 1.0% silicone penetrant, and the remainder is deionized water. The wetting and dispersing agent is composed of a polycarboxylate dispersant, fatty alcohol polyoxyethylene ether phosphate, and sodium salt of alkyl naphthalene sulfonic acid condensate in a weight ratio of 2:3:3. The stabilizer consists of sodium bisulfite and disodium ethylenediaminetetraacetate in a weight ratio of 1:1; The thickener consists of xanthan gum and magnesium aluminum silicate in a weight ratio of 1:2; Organosilicon penetrants consist only of polyether-modified trisiloxane.

[0062] A method for preparing a nanoscale suspension agent composed of kasugamycin and quinoline copper includes the following steps: S1. Add kasugamycin technical, quinoline copper technical, wetting and dispersing agent, propylene glycol, and organosilicon defoamer to deionized water, and shear for 40 min to obtain a crude suspension; S2. Pump the coarse suspension into a nano mill and grind it at 40°C for 80 minutes to stabilize the particle size D97 of the coarse suspension at the nano level. Stir at 80 rpm for 15 minutes, add thickener, stabilizer and organosilicon penetrant, and continue stirring at 80 rpm for 25 minutes to obtain a swollen solution. S3. The pH of the swelling solution was adjusted to 6 using sodium citrate, and then filtered through a 200-mesh nylon filter to obtain a nano-sized suspension.

[0063] Example 12 A nanoscale suspension agent composed of kasugamycin and quinoline copper, comprising the following raw materials by weight percentage: The composition of the product is as follows: 3.0% kasugamycin technical grade, 33.0% quinoline copper technical grade, 8.5% wetting and dispersing agent, 2.5% stabilizer, 0.5% thickener, 4.0% propylene glycol, 0.2% silicone defoamer, 1.0% silicone penetrant, and the remainder is deionized water. The wetting and dispersing agent is composed of a polycarboxylate dispersant, fatty alcohol polyoxyethylene ether phosphate, and sodium salt of alkyl naphthalene sulfonic acid condensate in a weight ratio of 2:3:3. The stabilizer consists of sodium bisulfite and disodium ethylenediaminetetraacetate in a weight ratio of 1:1; The thickener consists of xanthan gum and magnesium aluminum silicate in a weight ratio of 1:2; Organosilicon penetrants consist only of ethoxylated trisiloxanes.

[0064] A method for preparing a nanoscale suspension agent composed of kasugamycin and quinoline copper includes the following steps: S1. Add kasugamycin technical, quinoline copper technical, wetting and dispersing agent, propylene glycol, and organosilicon defoamer to deionized water, and shear for 40 min to obtain a crude suspension; S2. Pump the coarse suspension into a nano mill and grind it at 40°C for 80 minutes to stabilize the particle size D97 of the coarse suspension at the nano level. Stir at 80 rpm for 15 minutes, add thickener, stabilizer and organosilicon penetrant, and continue stirring at 80 rpm for 25 minutes to obtain a swollen solution. S3. The pH of the swelling solution was adjusted to 6 using sodium citrate, and then filtered through a 200-mesh nylon filter to obtain a nano-sized suspension.

[0065] Example 13 A nanoscale suspension agent composed of kasugamycin and quinoline copper, comprising the following raw materials by weight percentage: The composition of the product is as follows: 3.0% kasugamycin technical grade, 33.0% quinoline copper technical grade, 8.5% wetting and dispersing agent, 2.5% stabilizer, 0.5% thickener, 4.0% propylene glycol, 0.2% silicone defoamer, 1.0% silicone penetrant, and the remainder is deionized water. The wetting and dispersing agent is composed of a polycarboxylate dispersant, fatty alcohol polyoxyethylene ether phosphate, and sodium salt of alkyl naphthalene sulfonic acid condensate in a weight ratio of 2:3:3. The stabilizer consists of sodium bisulfite and disodium ethylenediaminetetraacetate in a weight ratio of 1:1; The thickener consists of xanthan gum and magnesium aluminum silicate in a weight ratio of 1:1; The organosilicon penetrant is composed of polyether-modified trisiloxane and ethoxy-modified trisiloxane in a weight ratio of 1:1.

[0066] A method for preparing a nanoscale suspension agent composed of kasugamycin and quinoline copper includes the following steps: S1. Add kasugamycin technical, quinoline copper technical, wetting and dispersing agent, propylene glycol, and organosilicon defoamer to deionized water, and shear for 40 min to obtain a crude suspension; S2. Pump the coarse suspension into a nano mill and grind it at 40°C for 80 minutes to stabilize the particle size D97 of the coarse suspension at the nano level. Stir at 80 rpm for 15 minutes, add thickener, stabilizer and organosilicon penetrant, and continue stirring at 80 rpm for 25 minutes to obtain a swollen solution. S3. The pH of the swelling solution was adjusted to 6 using sodium citrate, and then filtered through a 200-mesh nylon filter to obtain a nano-sized suspension.

[0067] Comparative Example 1 A nanoscale suspension agent composed of kasugamycin and quinoline copper, comprising the following raw materials by weight percentage: Kasugamycin technical grade 3.0%, quinoline copper technical grade 33.0%, stabilizer 2.5%, thickener 0.5%, propylene glycol 4.0%, silicone defoamer 0.2%, silicone penetrant 1.0%, balance deionized water; The stabilizer consists of sodium bisulfite and disodium ethylenediaminetetraacetate in a weight ratio of 1:1; The thickener consists of xanthan gum and magnesium aluminum silicate in a weight ratio of 1:2; The organosilicon penetrant is composed of polyether-modified trisiloxane and ethoxy-modified trisiloxane in a weight ratio of 1:1.

[0068] A method for preparing a nanoscale suspension agent composed of kasugamycin and quinoline copper includes the following steps: S1. Add kasugamycin technical, quinoline copper technical, propylene glycol, and organosilicon defoamer to deionized water and shear for 40 min to obtain a crude suspension; S2. Pump the coarse suspension into a nano mill and grind it at 40°C for 80 minutes to stabilize the particle size D97 of the coarse suspension at the nano level. Stir at 80 rpm for 15 minutes, add thickener, stabilizer and organosilicon penetrant, and continue stirring at 80 rpm for 25 minutes to obtain a swollen solution. S3. The pH of the swelling solution was adjusted to 6 using sodium citrate, and then filtered through a 200-mesh nylon filter to obtain a nano-sized suspension.

[0069] Comparative Example 2 A nanoscale suspension agent composed of kasugamycin and quinoline copper, comprising the following raw materials by weight percentage: The composition of the product is as follows: 3.0% kasugamycin technical grade, 33.0% quinoline copper technical grade, 8.5% wetting and dispersing agent, 2.5% stabilizer, 0.5% thickener, 4.0% propylene glycol, 0.2% silicone defoamer, and the remainder is deionized water. The wetting and dispersing agent is composed of a polycarboxylate dispersant, fatty alcohol polyoxyethylene ether phosphate, and sodium salt of alkyl naphthalene sulfonic acid condensate in a weight ratio of 2:3:3. The stabilizer consists of sodium bisulfite and disodium ethylenediaminetetraacetate in a weight ratio of 1:1; The thickener consists of xanthan gum and magnesium aluminum silicate in a weight ratio of 1:2.

[0070] A method for preparing a nanoscale suspension agent composed of kasugamycin and quinoline copper includes the following steps: S1. Add kasugamycin technical, quinoline copper technical, wetting and dispersing agent, propylene glycol, and organosilicon defoamer to deionized water, and shear for 40 min to obtain a crude suspension; S2. Pump the coarse suspension into a nano-sand mill and grind it at 40°C for 80 minutes to stabilize the particle size D97 of the coarse suspension at the nanoscale. Stir at 80 rpm for 15 minutes, add thickener and stabilizer, and continue stirring at 80 rpm for 25 minutes to obtain a swollen solution. S3. The pH of the swelling solution was adjusted to 6 using sodium citrate, and then filtered through a 200-mesh nylon filter to obtain a nano-sized suspension.

[0071] Experimental Example The nanoscale suspensions of kasugamycin and quinoline copper prepared in Examples 1-13 and Comparative Examples 1-2 were subjected to the following performance tests: (1) Initial suspension rate (%): The initial suspension rate was determined according to the method in GB / T 14825-2023 "Method for Determination of Suspension Rate of Pesticides"; (2) Degradation rate of active ingredients during heat storage (%): The heat storage stability test was carried out according to GB / T 19136-2021 "Test Method for Heat Storage Stability of Pesticides". The heat storage conditions were 54℃ for 14 days. The mass fraction of active ingredients before and after heat storage was tested, and the degradation rate of active ingredients was calculated. The degradation rate of active ingredients (%) = (mass fraction of active ingredients in the sample before heat storage - mass fraction of active ingredients in the sample after heat storage) / mass fraction of active ingredients in the sample before heat storage × 100%; (3) Heat storage water separation rate (%): After completing the heat storage stability test at 54℃ for 14 days according to the method in GB / T 19136-2021 "Determination of Heat Storage Stability of Pesticides", the sample was left to stand vertically for 24 hours, and the volume of clear water separated at the bottom of the graduated cylinder was read; Heat storage water separation rate = volume of water separated after heat storage / total volume of nano-sized suspension agent sample × 100%; (4) Leaf adhesion rate (%): Select uniform mature citrus leaves and spray them with blank formulation (without organosilicon penetrant) and nano-level suspension at the same dilution ratio. After natural drying, weigh the dry weight of the adhering liquid on the leaves; Leaf adhesion rate = (Nano-level suspension leaf adhesion mass - Blank formulation leaf adhesion mass without penetrant) / Blank formulation leaf adhesion mass without penetrant × 100%; (5) Foaming height (mL): Take 100mL of nano-sized suspension diluted 2000 times, transfer it into a 1000mL graduated stoppered cylinder, shake it vigorously up and down 30 times, let it stand at room temperature for 1 minute, and read the volume of the foam layer above the liquid surface, which is the foaming height. The test results are shown in Table 1.

[0072] Table 1 Performance test results of Examples 1-13 and Comparative Examples 1-2

[0073] Compared with Comparative Examples 1 and Examples 5-8, the initial suspension rate of the nanoscale suspending agents prepared in Examples 1-4 was improved and the degradation rate of the heat-storage effective components was reduced. This indicates that the addition of wetting and dispersing agents to the suspending agents, including polycarboxylate dispersants, fatty alcohol polyoxyethylene ether phosphates and sodium alkyl naphthalene sulfonic acid condensate, can effectively improve the suspension properties and stability of the suspending agents through the combined use of the three.

[0074] Compared with Comparative Example 2 and Examples 11-12, the leaf adhesion rate of the nanoscale suspension prepared in Examples 1-4 was improved, indicating that the addition of organosilicon penetrants to the suspension, including polyether-modified trisiloxanes and ethoxy-modified trisiloxanes, can effectively enhance the wettability and adhesion of the suspension on the plant surface through the combined use of polyether-modified trisiloxanes and ethoxy-modified trisiloxanes, ultimately contributing to the improvement of the suspension's stability.

[0075] Compared with Examples 9-10, the degradation rate of the heat-storage effective components in the nanoscale suspensions prepared in Examples 1-4 was reduced, indicating that the addition of sodium bisulfite and disodium ethylenediaminetetraacetate as stabilizers to the suspension, with a weight ratio of sodium bisulfite to disodium ethylenediaminetetraacetate of 1:1, can help improve the stability of the suspension. Compared with a single stabilizer, the degradation rate of the heat-storage effective components can be reduced by more than 60%.

[0076] The above are merely preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A nanoscale suspension agent composed of kasugamycin and quinoline copper, characterized in that, It consists of the following raw materials by weight percentage: Kasugamycin technical grade 2.0%~6.0%, quinoline copper technical grade 30.0%~34.0%, wetting and dispersing agent 7.0%~10.0%, stabilizer 2.0%~3.5%, thickener 0.3%~0.7%, antifreeze 3.0%~5.0%, defoamer 0.1%~0.3%, penetrant 0.5%~1.5%, balance being water; The sum of the weight percentages of the kasugamycin technical and the quinoline copper technical is 36.0%.

2. The nanoscale suspension agent of kasugamycin and quinoline copper compound according to claim 1, characterized in that, The weight percentage of the kasugamycin technical is 3.0%, and the weight percentage of the quinoline copper technical is 33.0%.

3. The nanoscale suspension agent of kasugamycin and quinoline copper compound according to claim 1, characterized in that, The wetting and dispersing agents include polycarboxylate dispersants, fatty alcohol polyoxyethylene ether phosphates, and sodium salts of alkyl naphthalene sulfonic acid condensates.

4. The nanoscale suspension agent of kasugamycin and quinoline copper compound according to claim 3, characterized in that, The weight ratio of the polycarboxylate dispersant, fatty alcohol polyoxyethylene ether phosphate, and sodium alkyl naphthalene sulfonic acid condensate is 2:2~3:3~4, preferably 2:3:

3.

5. The nanoscale suspension agent of kasugamycin and quinoline copper compound according to claim 1, characterized in that, The stabilizers include sodium bisulfite and disodium ethylenediaminetetraacetate; The weight ratio of sodium bisulfite to disodium ethylenediaminetetraacetate is 1 to 1.5:1, preferably 1:

1.

6. The nanoscale suspension agent of kasugamycin and quinoline copper compound according to claim 1, characterized in that, The thickeners include xanthan gum and magnesium aluminum silicate; The weight ratio of xanthan gum to magnesium aluminum silicate is 1:1.5~2, preferably 1:

2.

7. The nanoscale suspension agent of kasugamycin and quinoline copper compound according to claim 1, characterized in that, The penetrant is an organosilicon penetrant; the organosilicon penetrant includes polyether-modified trisiloxane and ethoxy-modified trisiloxane.

8. The nanoscale suspension agent of kasugamycin and quinoline copper compound according to claim 7, characterized in that, The weight ratio of the polyether-modified trisiloxane to the ethoxy-modified trisiloxane is 1:1 to 1.5, preferably 1:

1.

9. The nanoscale suspension agent of kasugamycin and quinoline copper according to claim 1, characterized in that, The antifreeze includes propylene glycol; The defoamer includes silicone defoamers.

10. A method for preparing a nanoscale suspension of kasugamycin and quinoline copper, used to prepare the nanoscale suspension of kasugamycin and quinoline copper as described in any one of claims 1 to 9, characterized in that, Includes the following steps: S1. Add the kasugamycin technical, quinoline copper technical, wetting and dispersing agent, antifreeze agent, and defoamer to water, and shear to obtain a crude suspension; S2. Grind the coarse suspension, stir once, add the thickener, the stabilizer and the penetrant, stir a second time to obtain a swelling solution; S3. Adjust the pH of the swelling solution to 4-7, filter, and obtain the nanoscale suspension.

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