A compound of naphthalene isoxazole amide and pyroxyfur ether, insecticide and application thereof

Abstract

The application discloses a naphthalene isoxazoles amide and pyriproxyfen compound composition, an insecticide and application thereof in the field of pesticide preparation and agricultural pest control. The compound composition is composed of naphthalene isoxazoles amide and pyriproxyfen, and the mass ratio of the naphthalene isoxazoles amide to the pyriproxyfen is 30:1-1:30. The mass percentage of the compound composition in the insecticide is 20-50%, and some necessary auxiliaries are further included. The insecticide can be applied in the prevention and treatment of agricultural crop pests. The naphthalene isoxazoles amide and the pyriproxyfen with completely different action mechanisms are compounded for the first time, and clear synergistic effect is shown. The effective component amount can be reduced under the same prevention effect, and the pesticide residue and environmental pollution risk are reduced. Meanwhile, one-time application can prevent multiple pests, the application frequency and labor cost are reduced. In addition, seed treatment tests show that the crop is safe under a certain amount, and there is no obvious adverse effect on non-target organisms, and the insecticide has a good popularization and application prospect.

Description

Technical Field

[0001] This invention relates to the field of pesticide formulation and agricultural pest control technology, specifically to a compound composition of naphthoxazoamide and pyriproxyfen, an insecticide and its application. Background Technology

[0002] In the production of vegetables, fruit trees, and field crops, piercing-sucking pests such as thrips, whiteflies, and aphids are prone to outbreaks year-round. Their rapid reproduction and significant generational overlap make chemical control increasingly difficult. In recent years, field control has relied on insecticides with single mechanisms of action, such as neonicotinoids and pyrethroids, leading to varying degrees of resistance in these pests. Simultaneously, different types of pests often occur together; for example, aphids and diamondback moths may simultaneously infest cabbage fields, or whiteflies and thrips may occur concurrently in cotton fields. Farmers often need to mix or rotate multiple pesticides in a short period, increasing labor costs and pesticide usage, and exacerbating the risk of pesticide residue exceeding limits.

[0003] Nafoxametamide is a newly developed isoxazoline insecticide with the chemical name 4-(5-(3-chloro-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazo-3-yl)-N-((methoxyimino)methyl)-1-naphthoamide and the molecular formula C2 24 H 16 ClF6N3O3 has a relative molecular mass of 543.85. This agent acts on the allosteric sites of the γ-aminobutyric acid (GABA)-gated chloride ion channels in insects, causing the pests to become overexcited and die by interfering with the normal transmission of inhibitory neural signals. It has outstanding killing effects on pests such as thrips, aphids, diamondback moths, and whiteflies, and has excellent safety for mammals and beneficial insects.

[0004] Pyriproxyfen is a diphenyl ether insect growth regulator, chemically named 4-phenoxyphenyl-(RS)-[2-(2-pyridyloxy)propyl] ether, with the molecular formula C2. 20 H 19 NO3 has a relative molecular mass of 321.37. Pyriproxyfen mimics juvenile hormone activity, interfering with the molting and metamorphosis processes of pests, preventing larvae from developing normally into adults, or causing a significant decrease in adult egg-laying and hatching rates, thereby achieving population control. Its mechanism of action is mainly through stomach poison and contact activity, and it has a long-lasting effect on suppressing the populations of homoptera pests such as whiteflies, aphids, and scale insects.

[0005] The two types of insecticides have fundamentally different mechanisms of action: naphthoxazoamide acts directly on chloride ion channels in the nervous system, exerting a rapid knockdown effect; while pyriproxyfen blocks the growth and development of pests through endocrine disruption, exerting a sustained population control effect. Theoretically, combining a fast-acting neurotoxin with a sustained-acting growth regulator could potentially achieve dual control effects. However, to date, there are no publicly available reports or patent documents on the combination of naphthoxazoamide and pyriproxyfen, and the industry lacks predictable data to support the combined toxicity type (additive, antagonistic, or synergistic) of the two agents. Summary of the Invention

[0006] The purpose of this invention is to provide a compound composition of naphthoxazoamide and pyriproxyfen, an insecticide and its application, to overcome the problems of narrow control spectrum, insufficient rapid or sustained effect, and high risk of resistance of single agents.

[0007] The present invention achieves the above objectives through the following technical solutions: A compound composition of naphthoisoxaazole amide and pyriproxyfen, wherein the compound composition is composed of naphthoisoxaazole amide and pyriproxyfen, and the mass ratio of naphthoisoxaazole amide to pyriproxyfen is 30:1 to 1:30. The chemical name of the naphthoisoxazole amide is 4-(5-(3-chloro-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3-yl)-N-((methoxyimino)methyl)-1-naphthoamide, and the chemical name of the pyriproxyphenyl is 4-phenoxyphenyl-(RS)-[2-(2-pyridyloxy)propyl] ether.

[0008] A further improvement is that the mass ratio of naphthoxazoamide to pyriproxyfen is 1:1 to 1:5.

[0009] A further improvement is that the mass ratio of naphthoxazoamide to pyriproxyfen is 1:1.

[0010] The present invention also provides an insecticide containing the aforementioned compound composition.

[0011] A further improvement is that the compound composition in the insecticide has a mass percentage of 20-50%.

[0012] A further improvement is that the insecticide is formulated as a suspension concentrate, water-dispersible granules, wettable powder, microemulsion, water-in-oil emulsion, dispersible oil suspension, microcapsule suspension, emulsifiable concentrate, or seed treatment suspension.

[0013] A further improvement is that the insecticide also contains one or more of the following: dispersant, wetting agent, emulsifier, thickener, antifreeze, defoamer, preservative, pH adjuster, disintegrant, and solid filler. The adjuvants used can be selected according to conventional methods in the art, such as polycarboxylate dispersants, naphthalene sulfonate formaldehyde condensates, calcium lignosulfonate, sodium dodecyl sulfate, fatty alcohol ethoxylates, alkylphenol ethoxylates, calcium dodecylbenzene sulfonate, castor oil polyoxyethylene ether, xanthan gum, magnesium aluminum silicate, propylene glycol, ethylene glycol, organosilicon defoamers, Kathon, sodium benzoate, kaolin, silica, bentonite, ammonium sulfate, etc.

[0014] The present invention also provides an application of the insecticide in the control of agricultural crop pests.

[0015] A further improvement is that the pests are one or more of thrips, whiteflies, aphids, or lepidopteran pests, and the crops are rice, corn, fruit trees, vegetables, cotton, soybeans, peanuts, or flowers.

[0016] A further improvement is that the application is either foliar spraying or seed treatment; for foliar spraying, the insecticide is diluted with water to an effective ingredient concentration of 25-55 mg / L, and sprayed evenly on both sides of the crop leaves at the early stage of pest occurrence or during the early nymphal stage, with an application interval of 7-14 days, and 1-2 applications; for seed treatment, the seed treatment suspension is mixed with seeds at a dosage of 300-900 mL / 100 kg of seeds, or the seeds are coated or mixed with seeds at a dosage of 90-270 g / 100 kg of seeds, and then sown after drying.

[0017] The beneficial effects of this invention are as follows: This invention is the first to combine naphthoxazoamide and pyriproxyfen, which have completely different mechanisms of action. Indoor toxicity tests show that, within a mass ratio range of 30:1 to 1:30, the co-toxicity coefficients of the compound composition against aphids, whiteflies, western flower thrips, and diamondback moths are all greater than 120, demonstrating a clear synergistic effect. Field efficacy trials further confirm that the compound insecticide combines the rapid knockdown effect of naphthoxazoamide with the sustained-release and propagation-controlling effect of pyriproxyfen. One day after application, its control efficacy against aphids, thrips, and other pests is significantly better than that of pyriproxyfen alone, and 21 to 30 days after application, its control efficacy is still significantly better than that of naphthoxazoamide alone. Under the same control efficacy, the effective ingredient can be reduced. This compound formulation reduces pesticide residues and environmental pollution risks. Simultaneously, it broadens the control spectrum against pests such as thrips, whiteflies, aphids, and diamondback moths, enabling control of multiple pests with a single application, reducing the number of applications and labor costs. Furthermore, its dual-target mechanism effectively delays the development of pesticide resistance in pests. Seed treatment trials show that the compound seed treatment suspension has no significant impact on rice and corn germination rates at dosages of 300–900 mL / 100 kg of seeds. It is safe for crops such as cabbage, cotton, and citrus at recommended dosages and twice the recommended dosages, and has no significant adverse effects on non-target organisms such as spiders, ladybugs, and lacewings in the field, demonstrating promising prospects for widespread application. Detailed Implementation

[0018] The present application will be further described in detail below with reference to specific embodiments. It should be noted that the following specific embodiments are only used to further illustrate the present application and should not be construed as limiting the scope of protection of the present application. Those skilled in the art can make some non-essential improvements and adjustments to the present application based on the above application content.

[0019] I. Indoor Combined Toxicity Assay The test targets were adult aphids, adult whiteflies, adult western flower thrips, and third-instar larvae of diamondback moths. The test agents were naphthoxazolamide technical and pyriproxyfen technical, dissolved in acetone to prepare stock solutions, which were then diluted with water containing 0.1% Tween-80. Leaf dipping or leaf film application methods were used, with five concentration gradients per treatment, 30 insects per concentration, and four replicates. Water served as a blank control. After treatment, the insects were cultured at 25±1℃, 65%±5% relative humidity, and a photoperiod of 16L:8D. Mortality was assessed after 24–48 hours. The co-toxicity coefficient (CTC) was calculated using the Sun Yunpei co-toxicity coefficient method. CTC < 100 indicated antagonism, 100 ≤ CTC < 120 indicated additive effects, and CTC ≥ 120 indicated synergistic effects.

[0020] Table 1: Indoor toxicity of naphthozodamide and pyriproxyfen combined in combination ;

[0021] As shown in Table 1, the synergistic effect is significant in the mass ratio range of 30:1 to 1:30, with the highest co-toxicity coefficient in the range of 1:1 to 1:5.

[0022] II. Examples of Insecticide Formulations Example 1: 25% Naphthoxazolamide·Pyriproxyfen suspension Formula: Naphthylisoxazole amide 5%, pyriproxyfen 20%, polycarboxylate dispersant T36 3%, naphthalenesulfonate formaldehyde condensate NNO 3%, fatty alcohol ethoxylate AEO-40 1.5%, xanthan gum 0.32%, magnesium aluminum silicate 1.5%, propylene glycol 4%, silicone defoamer 0.15%, Kathon 0.4%, water to 100%. The mixture is homogenized, filtered, and filled using a high-speed shearing and sand mill circulating grinding process to a D90 < 5μm.

[0023] Example 2: 40% Naphthoxazolamide·pyriproxyfen water-dispersible granules Formula: Naphthylisoxazole amide 8%, pyriproxyfen 32%, polycarboxylate dispersant 5%, naphthalene sulfonate formaldehyde condensate 7%, fatty alcohol ethoxylate 2%, ammonium sulfate 15%, bentonite to 100%. Mix, air-jet mill, add water for granulation, and dry.

[0024] Example 3: 30% Naphthoxazolamide·Pyriproxyfen Microemulsion Formula: Naphthylisoxazole amide 10%, pyriproxypyridine 20%, styrene-phenol polyoxyethylene ether 12%, calcium dodecylbenzenesulfonate 5%, N-methylpyrrolidone 8%, sec-butyl acetate 5%, ethylene glycol 4%, water to 100%. Mix the oil phase and water phase and stir until transparent.

[0025] Example 4: 50% Naphthoxazolamide·Pyriproxyfen wettable powder Formulation: Naphthylisoxazole amide 10%, pyriproxyfen 40%, polycarboxylate dispersant 3%, naphthalene sulfonate dispersant 5%, sodium dodecyl sulfate 1.5%, silica 3%, kaolin to make up to 100%. Mix and ultrafine grind to a 45μm sieve with a passing rate ≥99%.

[0026] Example 5: 20% Naphthoxazolamide·Pyriproxyfen aqueous emulsion Formula: Naphthylisoxazole amide 5%, pyriproxyfen 15%, solvent oil S-150 20%, acetophenone 8%, calcium dodecylbenzenesulfonate 1.5%, tristyrene-phenylphenol polyoxyethylene ether phosphate 5%, castor oil polyoxyethylene ether 2.5%, xanthan gum 0.2%, Kathon 0.3%, propylene glycol 5%, water to 100%. The oil and aqueous phases are mixed by high-speed shear mixing.

[0027] Example 6: 35% Naphthoxazolamide·pyriproxyfen dispersible oil suspension Formula: Naphthylisoxazole amide 10%, pyriproxyfen 25%, castor oil polyoxyethylene ether 10%, styrene-phenol polyoxyethylene ether 5%, calcium dodecylbenzenesulfonate 3%, organobentonite 2.5%, silica 1%, methyl oleate to 100%. Mill and homogenize.

[0028] Example 7: 50% Naphthoxazolamide·pyriproxyfen water-dispersible granules Formulation: Naphthylisoxazole amide 10%, pyriproxyfen 40%, polycarboxylate dispersant 6%, naphthalene sulfonate formaldehyde condensate 8%, fatty alcohol ethoxylate 2%, ammonium sulfate 18%, bentonite to 100%. Granulation and drying.

[0029] Example 8: 20% Naphthoxazolamide·Pyriproxyfen Microcapsule Suspension Formulation: Naphthylisoxazole amide 8%, pyriproxypyridine 12%, urea-formaldehyde resin prepolymer 8%, calcium dodecylbenzenesulfonate 2%, styrene-based phenol polyoxyethylene ether 3%, xanthan gum 0.2%, propylene glycol 4%, water to 100%. Microcapsules were prepared by interfacial polymerization, and then filled into slurry.

[0030] Example 9: 45% Naphthoxazolamide·Pyriproxyfen suspension Formula: Naphthylisoxazole amide 22.5%, pyriproxyfen 22.5%, calcium lignosulfonate 3%, naphthalenesulfonate formaldehyde condensate 4%, sodium dodecyl sulfate 1%, propylene glycol 5%, silicone defoamer 0.15%, sodium benzoate 0.3%, xanthan gum 0.25%, water to 100%. Sand mill to D90 < 5μm.

[0031] Example 10: 22% Naphthoxazolamide·Pyriproxyfen EC Formula: Naphthylisoxazoamide 6%, pyriproxypropyl ether 16%, calcium dodecylbenzenesulfonate 6%, agricultural emulsion 400 4%, tristyrene-phenylphenol polyoxyethylene polyoxypropylene ether 7%, N,N-dimethylacetamide 10%, alcohol ether solvent 10%, solvent oil S-200 to 100%. Stir until dissolved and clear.

[0032] Example 11: 30% Naphthoxazolamide·pyriproxyfen seed treatment suspension Formula: Naphthylisoxazole amide 8%, pyriproxyfen 22%, polycarboxylate dispersant 3%, naphthalenesulfonate formaldehyde condensate 3%, fatty alcohol ethoxylate 1.5%, permanent red 5%, film-forming agent polyvinyl alcohol 2%, xanthan gum 0.2%, magnesium aluminum silicate 1%, propylene glycol 4%, silicone defoamer 0.1%, Kathon 0.3%, water to 100%. Mill to D90 < 4μm, homogenize and fill.

[0033] Example 12: 35% Naphthoxazolamide·Pyriproxyfen Microemulsion Formula: Naphthylisoxazole amide 10%, pyriproxypyridine 25%, styrene-phenol polyoxyethylene ether 15%, calcium dodecylbenzenesulfonate 4%, N-methylpyrrolidone 6%, solvent oil No. 200 10%, ethylene glycol 4%, water to 100%. Add the oil phase to the aqueous phase and stir until transparent.

[0034] III. Preparation Quality Testing The active ingredient content, pH, suspension rate, thermal decomposition rate, low-temperature stability, wet sieving test, persistent foaming property, particle size, pourability, emulsion stability, transparency temperature range, disintegration time, and moisture content of each formulation were tested. Some results are shown in Table 2.

[0035] Table 2: Quality Inspection Results of Some Formulations ;

[0036] The results in Table 2 show that the physicochemical properties of each formulation are stable and meet the quality control requirements for pesticide formulations.

[0037] IV. Field efficacy trials 1. Control of cabbage aphids The test reagent was the 25% suspension of Example 1, with three active ingredient concentrations of 25, 40, and 55 mg / L. 25% naphthoxazoamide suspension (40 mg / L) and 10% pyriproxyfen emulsifiable concentrate (40 mg / L) served as controls. Each treatment was replicated four times, with assessments conducted at 1, 3, 7, 14, and 21 days post-treatment.

[0038] Table 3: Field control efficacy against cabbage aphids ;

[0039] Table 3 shows that the control efficacy of 25% naphthozoamide·pyriproxyfen suspension against cabbage aphids increased with increasing dosage within the range of 25–55 mg / L active ingredient. One day after application, the control efficacy of the 40 mg / L compound treatment was 79.2%, significantly higher than the 42.8% of pyriproxyfen alone, indicating a substantial improvement in rapid action after compounding. Seven days after application, the control efficacy of the compound treatment reached 95.8%, an increase of 2.7 and 13.2 percentage points compared to naphthozoamide and pyriproxyfen alone, respectively. Twenty-one days after application, the control efficacy of the compound treatment remained at 94.3%, an increase of 10.1 percentage points compared to naphthozoamide alone, indicating that the sustained-release effect of pyriproxyfen effectively prolonged the duration of action of the compound formulation. The control efficacy of the 55 mg / L treatment reached 96.1% 21 days after application, indicating that increasing the dosage could further improve the control efficacy, but 40 mg / L was sufficient to meet the control requirements. Overall, the results show that this compound composition has a significant synergistic effect on cabbage aphids, and has both rapid and sustained effects.

[0040] 2. Control of cotton whiteflies The test reagent was the 40% water-dispersible granules of Example 2, at a dosage of 45 mg / L. The controls were naphthoxazoamide (50 mg / L) and pyriproxyfen (50 mg / L).

[0041] Table 4: Field control efficacy against cotton whitefly ;

[0042] Table 4 shows that in the cotton whitefly control experiment, the control efficacy of 40% naphthoxazoamide·pyriproxyfen water-dispersible granules at a dosage of 45 mg / L active ingredient was 90.2%, 94.6%, 96.8%, and 95.1% at 3, 7, 14, and 21 days after application, respectively, all significantly higher than that of 25% naphthoxazoamide suspension concentrate and 10% pyriproxyfen emulsifiable concentrate alone. Specifically, at 3 days after application, the efficacy of the compound formulation was 28.9 percentage points higher than that of pyriproxyfen alone and 3.7 percentage points higher than that of naphthoxazoamide alone, indicating that the rapid neurotoxic effect of naphthoxazoamide effectively compensated for the slow initial effect of pyriproxyfen alone. At 7 and 14 days after application, the efficacy of the compound formulation reached 94.6% and 96.8%, respectively, significantly higher than both single agents, indicating that the synergistic effect of the compound formulation lasted throughout the middle stages after application. Thirty days after application, the efficacy of the compound formulation remained at 90.7%, 9.3 percentage points higher than that of naphthoxazoamide alone, and roughly equivalent to that of pyriproxyfen alone. However, the efficacy fluctuated less throughout the entire survey period, demonstrating superior overall efficacy. These results indicate that the compound formulation possesses both rapid and sustained effects against cotton whiteflies, effectively reducing the whitefly population and delaying the development of resistance.

[0043] 3. Chrysanthemum thrips control The test reagent was the 30% microemulsion of Example 3, at a dosage of 35 mg / L.

[0044] Table 5: Field control efficacy against Chrysanthemum thrips ;

[0045] Table 5 shows that in the thrips control experiment on chrysanthemum flowers, the 30% naphthoxazoamide·pyriproxyfen microemulsion, at a dosage of 35 mg / L of active ingredient, achieved a control efficacy of 91.8% three days after application, which was 3.4 percentage points higher than naphthoxazoamide alone and 33.1 percentage points higher than pyriproxyfen alone, demonstrating excellent rapid insecticidal ability. At 7 and 14 days after application, the control efficacy reached 95.7% and 97.3% respectively, both significantly higher than the two single agents, indicating that the compound formulation not only had a rapid onset of action but also a stable pest control effect. At 21 days after application, the control efficacy of the compound formulation remained at 94.6%, 6.4 percentage points higher than naphthoxazoamide alone and 2.9 percentage points higher than pyriproxyfen alone, indicating that the sustained inhibitory effect of pyriproxyfen on thrips reproduction and development significantly prolonged the duration of effectiveness of the compound formulation. In summary, the combination of naphthoxazoamide and pyriproxyfen showed a significant synergistic effect against western flower thrips, with both faster and longer-lasting effects than either agent, making it suitable for the efficient control of thrips in flowers.

[0046] V. Effects of Seed Treatment on Germination Rate and Safety Tests To evaluate the effects of the compound composition as a seed treatment agent on crop emergence and early growth, following field efficacy trial specifications, the 30% naphthoxazolamide·pyriproxyfen seed treatment suspension prepared in Example 11 was used to conduct emergence rate and safety tests on rice and maize. Emergence rate was calculated using the following formula: Emergence rate (%) = (Number of seedlings / Number of seeds) × 100 Data were processed using Excel 2010 and DPS 7.05, and the significance of differences was determined using Duncan's new multiple range method.

[0047] 1. Impact of rice emergence rate Three treatments were set up: seed treatment suspension at 300, 600, and 900 mL / 100 kg of seeds. The control was 25% naphthoxazole amide suspension at 600 mL / 100 kg of seeds. A blank control was also included. The germination rate was investigated 10 days after sowing, with fixed-point surveys in each plot and four replicates.

[0048] Table 6: Effects of seed treatment on rice emergence rate ;

[0049] Table 6 shows that the rice emergence rates of the 30% naphthoxazoamide·pyriproxyfen seed treatment suspension at dosages of 300, 600, and 900 mL / 100 kg of seeds were 89.6%, 90.3%, and 89.1%, respectively. The emergence rate of the control agent, 25% naphthoxazoamide suspension at 600 mL / 100 kg of seeds, was 89.9%, while the blank control was 90.5%. Furthermore, the analysis of variance showed no significant difference in rice emergence rates among the treatments (F=0.48, p=0.75>0.05). This indicates that the compound seed treatment suspension has no adverse effects on rice emergence within the experimental dosage range and is safe for use in rice seed treatment.

[0050] 2. Impact of corn emergence rate Three treatments were established: seed treatment suspension at 300, 600, and 900 mL / 100 kg of seeds. The control was 25% naphthoxazole amide suspension at 600 mL / 100 kg of seeds. A blank control was also established. The number of seedlings emerging was assessed at 7 and 15 days after sowing and expressed as the number of seedlings emerging in double rows per meter.

[0051] Table 7: Effects of seed treatment on maize emergence rate ;

[0052] Table 7 shows that the 30% naphthoxazoamide·pyriproxyfen seed treatment suspension, at application rates of 300, 600, and 900 mL / 100 kg of seed, resulted in 18.42–18.76 plants / m double-row corn seedlings 7 days after sowing and 18.65–18.92 plants / m double-row corn seedlings 15 days after sowing. The control groups showed 18.71 and 18.88 plants / m double-row corn seedlings, respectively. There were no significant differences between the treatments and the control and blank control treatments (p > 0.05). Field observations showed uniform corn seedling emergence in all treatments, with no observed symptoms of phytotoxicity such as dwarfing, yellowing, or leaf curling. This indicates that the compound seed treatment suspension is safe for corn seedling emergence at application rates of 300–900 mL / 100 kg of seed and can be used as a corn seed treatment agent.

[0053] 3. Crop safety assessment No significant phytotoxicity symptoms were observed in rice, corn, cabbage, cotton, and citrus at the recommended dosage and twice the recommended dosage. Only at three times the recommended dosage did a few citrus shoots and leaves experience slight water loss, which recovered within three days and did not affect yield or quality. This indicates that the compound seed treatment suspension is safe for crops within the recommended dosage range.

[0054] VI. Impact of Non-Target Organisms and Natural Enemies Investigations in seed treatment and foliar spraying test fields showed that the compound insecticide, at the supplied dosage, had no significant adverse effects on the populations of major natural enemies such as spiders, ladybugs, and lacewings, and posed a low risk of short-term contact with non-target organisms such as bees and silkworms. No significant impacts on neighboring crops, non-target organisms, or beneficial organisms were observed during the experiment.

[0055] VII. Insecticide spectrum and preventive effect The 45% suspension concentrate of Example 9 was sprayed at 40 mg / L in a cabbage field to investigate its concurrent control effects against aphids, diamondback moths, and whiteflies.

[0056] Table 8: Concurrent control effect of compound insecticides on multiple pests in cabbage fields ;

[0057] Table 8 shows that (single-agent data from the same batch of experiments are cited from the previous table), 45% naphthoxazoamide·pyriproxyfen suspension concentrate, at a dosage of 40 mg / L active ingredient, exhibited good concurrent control effects against three target pests: aphids, diamondback moths, and whiteflies in cabbage fields. Three days after application, the control efficacy of the compound formulation against aphids, diamondback moths, and whiteflies was 91.4%, 89.7%, and 88.4%, respectively, all significantly higher than the corresponding control efficacies of pyriproxyfen alone (65.3%, 58.4%, and 61.3%), indicating that the rapid neurotoxic effect of naphthoxazoamide effectively compensated for the slow initial effect of pyriproxyfen alone. Seven days after application, the control efficacy of the compound formulation against the three pests reached 95.5%, 94.6%, and 93.2%, respectively, representing an increase of 2.4% compared to naphthoxazoamide alone. The efficacy rates of the compound formulation against aphids, diamondback moths, and whiteflies were 1.8, 2.9, and 2.9 percentage points higher than those of pyriproxyfen alone, respectively, representing increases of 12.9, 23.4, and 14.7 percentage points. This indicates that the synergistic effect of the compound formulation was prominent in the mid-term after application. At 14 days post-application, the control efficacy of the compound formulation against aphids, diamondback moths, and whiteflies remained at 97.3%, 93.8%, and 96.5%, respectively. The control efficacy against whiteflies was 4.4 percentage points higher than that of naphthoxazoamide alone, indicating that the sustained inhibitory effect of pyriproxyfen on whitefly population reproduction effectively prolonged the duration of the compound formulation's efficacy. In contrast, the control efficacy of pyriproxyfen alone against diamondback moths was relatively low (only 76.5% at 14 days post-application), and the control efficacy of naphthoxazoamide alone against whiteflies was 92.1% at 14 days post-application, both lower than the overall performance of the compound formulation against all targets. The above results indicate that the combination of naphthoxazoamide and pyriproxyfen effectively broadens the insecticidal spectrum, achieving simultaneous prevention and control of aphids, diamondback moths, and whiteflies. Furthermore, both the rapid and sustained effects are significantly improved, reducing the number of field applications and labor costs.

[0058] The embodiments described above are merely examples of several implementations of the present invention, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the present invention. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these modifications and improvements all fall within the scope of protection of the present invention.

Claims

1. A compound composition of naphthoxazoamide and pyriproxyfen, characterized in that, The compound composition consists of naphthoxazoamide and pyriproxyfen, and the mass ratio of naphthoxazoamide to pyriproxyfen is 30:1 to 1:

30. The chemical name of the naphthoisoxazole amide is 4-(5-(3-chloro-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3-yl)-N-((methoxyimino)methyl)-1-naphthoamide, and the chemical name of the pyriproxyphenyl is 4-phenoxyphenyl-(RS)-[2-(2-pyridyloxy)propyl] ether.

2. The compound composition according to claim 1, characterized in that, The mass ratio of naphthoxazoamide to pyriproxyfen is 1:1 to 1:

5.

3. The compound composition according to claim 2, characterized in that, The mass ratio of naphthoxazoamide to pyriproxyfen is 1:

1.

4. An insecticide comprising the compound composition according to any one of claims 1 to 3.

5. The insecticide according to claim 4, characterized in that, The compound composition in the insecticide has a mass percentage of 20-50%.

6. The insecticide according to claim 4, characterized in that, The insecticide is formulated as a suspension concentrate, water-dispersible granule, wettable powder, microemulsion, water-in-oil emulsion, dispersible oil suspension, microcapsule suspension, emulsifiable concentrate, or seed treatment suspension.

7. The insecticide according to claim 4, characterized in that, The insecticide also contains one or more of the following: dispersant, wetting agent, emulsifier, thickener, antifreeze, defoamer, preservative, pH adjuster, disintegrant, and solid filler.

8. The application of the insecticide as described in claim 4 in the control of agricultural crop pests.

9. The application according to claim 8, characterized in that, The pests are one or more of the following: thrips, whiteflies, aphids, or lepidopteran pests; the crops are rice, corn, fruit trees, vegetables, cotton, soybeans, peanuts, or flowers.

10. The application according to claim 8, characterized in that, The application is foliar spraying or seed treatment. For foliar spraying, dilute the insecticide with water to an effective ingredient concentration of 25-55 mg / L, and spray it evenly on both sides of the crop leaves at the early stage of pest occurrence or the early nymph stage. The interval between applications is 7-14 days, and the application is 1-2 times. For seed treatment, mix the seed treatment suspension with seeds at a dosage of 300-900 mL / 100 kg of seeds, or coat or mix the seeds with seeds at a dosage of 90-270 g / 100 kg of seeds, and sow after drying.