A triple sustained-release spread-on mosquito repellent and a preparation method thereof

Abstract

The present application belongs to the technical field of mosquito repellents, and particularly relates to a triple-sustained mosquito repellent in the form of smearing and a preparation method thereof. The triple-sustained mosquito repellent in the form of smearing comprises the following components in the following weight contents: ecarriidine 8-12%, medium-chain oil 1.37-1.72% or dicaprylyl carbonate 1.37-1.72; menthyl lactate or mint oil 1.56-1.87%, oily gel 0.28-0.60%, sodium starch glycolate 0.31-0.36%, potassium cinnamate 0.05-0.06%, carbomer 0.65-0.70%, and the rest is water. The oily gel makes the oil solution of ecarriidine become thickened or semi-solidified. The sodium starch glycolate forms a tough and unbreakable film on the oil-water interface of the oil-in-water emulsion with a polysaccharide long-chain large group covering the oil surface, and then the emulsion forms an emulsion gel with the help of the carbomer, greatly slowing down the volatilization of ecarriidine, and forming a triple-sustained effect as a whole. In the process, no organic solvents such as ethanol are used, and the problems of poor water resistance, poor production safety, high production cost and short mosquito repellent time of the traditional mosquito repellents are solved.

Description

[Technical Field]

[0001] This invention belongs to the field of mosquito repellent technology, specifically relating to a triple-release topical mosquito repellent and its preparation method. [Background Technology]

[0002] With rising living standards and rapid urbanization, people are increasingly enthusiastic about outdoor leisure activities and travel in spring, summer, and autumn, leading to a growing demand for environmentally friendly mosquito and insect repellents. Icaretin, also known as hydroxymethylphenidate, KBR3023, picaridin, and cytoretin, is a low-volatility, colorless to pale yellow clear liquid. Developed by Bayer AG in the 1990s, it is a mosquito repellent with extremely low toxicity and is classified as a Category III toxicity agent by the U.S. Environmental Protection Agency, meaning it is harmless to humans. Topical tests have shown that only 5% of picaridin is absorbed by human skin, less than one-sixth that of the gold standard repellent DEET. It has a broad-spectrum repellent effect against various insects, including mosquitoes, ticks (or lice), biting flies, sand flies, grasshoppers, sand mites, ginger mites, and other small flying insects. Furthermore, in comparative tests of picaridin against DEET and IR3535 for up to 14 hours of mosquito and tick bite protection and 8 hours of fly, mosquito, grasshopper, sand mite, and ginger mite bite protection, picaridin showed the longest-lasting effect. In addition, picaridin has a non-greasy texture, no noticeable odor, and will not damage plastic or synthetic fiber clothing, offering a high level of safety. Currently, picaridin is a product recommended by the World Health Organization (WHO) for malaria prevention, and it is registered for use in more than 40 countries worldwide.

[0003] In existing technologies, ethanol and isopropanol are commonly used as solvents to formulate icoplanin into topical sprays, or chloroalkanes are used as solvents to formulate icoplanin into propellants. However, these products can irritate human skin and respiratory tract, resulting in low safety during production and use, and failing to realize the long-lasting mosquito-repellent advantage of icoplanin. Furthermore, existing technologies also employ encapsulation methods such as microcapsules, cyclodextrin, porous silica, and multi-channel silica to prepare mosquito-repellent ointments. While this method can achieve long-lasting, sustained-release mosquito repellency, after the moisture or solvent completely evaporates, the ointment leaves the skin feeling hard and uncomfortable. Moreover, this method of ointment preparation is complex and costly.

[0004] A Chinese invention patent with application number CN202311242330.7 and application date of 2023-09-25 discloses a low-irritation, long-lasting polyurethane-hydroxypiperidine mosquito repellent. This repellent achieves a slow-release mosquito repellent effect by forming strong hydrogen bonds between the numerous alicyclic isophorone diisocyanate (IPDI) groups in the polyurethane polymer and the piperidine groups in icolinergic acid, thereby reducing volatilization. However, polyurethane degrades and releases IPDI in hot weather, forming aerosols that strongly irritate the eyes and respiratory mucosa. Its lacrimal effect also poses potential toxicity to humans. Furthermore, the use of ethanol and 1,3-butanediol as solvents or in the preparation of the compound in this patent could easily lead to production safety issues.

[0005] A Chinese invention patent with application number CN201010191632.2 and application date of 2010-06-04 discloses a mosquito repellent, which uses organic solvents such as ethanol, isopropanol, and propanol, as well as complex organic compounds such as organic acids, polyurethane, and cyclodextrin. Ethanol, isopropanol, and propanol are all flammable and explosive organic solvents with low flash points. Explosion-proof and fire-proof equipment is required during production, and explosion-proof and ventilated warehouses are needed to store raw materials. The filling of the manufactured product also requires safe conditions and corresponding hardware facilities. The use of cyclodextrin, porous silica, and fumed silica to encapsulate the mosquito repellent requires certain technology and a relatively complex encapsulation process and detection and monitoring methods to achieve successful encapsulation. The entire production process is complex, the production cost is too high, and there are significant safety hazards.

[0006] A Chinese invention patent with application number CN202211139597.9 and application date of 2022-09-19 discloses a slow-release mosquito repellent technology. It discloses a special slow-release material with silica special particles having disordered mesoporous channels. Combined with ethanol, water, glycerin, etc., the mosquito repellent ingredients are encapsulated in it to exert a slow-release effect. This technology is similar to cyclodextrin encapsulation. After the solvent evaporates, the silica left behind will make the skin feel hard and cause discomfort.

[0007] A Chinese invention patent with application number CN201410403018.6 and application date of August 15, 2014, discloses a mosquito repellent and sunscreen gel and its preparation method. The patent discloses the use of fumed silica as a thickening and slow-release agent. Fumed silica is a white, non-toxic, amorphous, microporous, highly dispersed, lightweight hydrated silica. It also relies on the principle of pores to encapsulate and exert a slow-release effect. By making the product into a hydrogel or cream, the mosquito repellency time is extended. However, the process disclosed in this patent requires the use of ethanol for preparation, which results in low production safety. Furthermore, the mosquito repellency and slow-release effects of the hydrogel and cream are significantly insufficient, and the extended mosquito repellency time is limited. [Summary of the Invention]

[0008] The purpose of this invention is to provide a method for preparing a triple-release, topical mosquito repellent, thereby solving the technical problems of poor water resistance, poor production safety, high production costs, and short mosquito-repelling time in existing mosquito repellents. Another purpose of this invention is to provide a triple-release, topical mosquito repellent to solve the aforementioned technical problems.

[0009] This invention provides a method for preparing a triple-release, topical mosquito repellent, the technical solution of which is as follows:

[0010] A method for preparing a triple-release topical mosquito repellent, characterized in that the method for preparing the mosquito repellent is as follows:

[0011] Icaridin is mixed with one of medium-chain oil and dioctyl carbonate, one of menthyl lactate and peppermint oil in a certain proportion to prepare an iccaridin mixed oil solution. Then, at least one of rice bran wax, glyceryl monostearate and dextrin palmitate is added in a certain proportion and mixed and stirred. The mixture is heated to 40-55℃ to prepare solution 1, which is kept warm for later use.

[0012] Take sodium octenyl succinate starch and potassium cinnamate, add deionized water and stir, dissolve at 40-55℃ to prepare solution 2, keep warm for later use;

[0013] Take carbomer, add deionized water and stir or shear to dissolve it into a semi-transparent solution 3, for later use.

[0014] Slowly add solution 1 to solution 2, which is kept at a constant temperature, while stirring. After the solution is completely added, allow it to cool naturally to room temperature and then shear and homogenize to obtain an oil-in-water gel emulsion for later use.

[0015] Stir or shear homogenize solution 3, add oil-in-water gel emulsion, shear homogenize, adjust the pH to 6.8-7.5, shear homogenize again to obtain the triple-release topical mosquito repellent.

[0016] Furthermore, the carbomer used is either the 940 or 980 type.

[0017] Further, when solution 1 is slowly added to solution 2 which is kept at a constant temperature, the mixture is sheared and homogenized at a speed of 1000-1500 r / m for 30 minutes to obtain an oil-in-water gel emulsion.

[0018] Furthermore, when stirring or shearing the homogenized solution 3, shear homogenize at a speed of 1000-1500 r / m for 30 minutes, then adjust the pH value to 6.8-7.5, and then shear homogenize at a speed of 1000-1500 r / m for 10 minutes or stir for 15-20 minutes.

[0019] Furthermore, while stirring or shearing the homogenized solution 3, add a saturated sodium carbonate or sodium bicarbonate aqueous solution to adjust the pH to 6.8-7.5.

[0020] The beneficial effects are:

[0021] 1. Rice bran wax, glyceryl monostearate, and dextrin palmitate are all gelling agents that can form oleogels. They can be used as cosmetic grade gels, are non-irritating to the skin, and are safe and comfortable. In particular, when rice bran wax is used to prepare a thickened or semi-solidified oleogel by mixing icocaritin with a mixed oil solution of menthol lactate or peppermint oil, medium-chain oil or dioctyl carbonate, it feels light, non-greasy, soft and silky when applied to the skin.

[0022] 2. The mixed oil solution formed by icocaritin with medium-chain oil or dioctyl carbonate, menthyl lactate or peppermint oil is conducive to dissolving oily gelling agents such as rice bran wax, glyceryl monostearate, and dextrin palmitate at 40-55℃ to form a pre-oil gel. At temperatures below 40℃, the pre-oil gel thickens or forms a semi-solid oil gel, which greatly reduces the volatilization of icocaritin and thus exerts a slow-release mosquito repellent effect.

[0023] 3. The process does not use flammable and explosive organic solvents such as ethanol, and all raw materials are recognized safe excipients of food or cosmetic grade, which avoids safety hazards in the production process and avoids the irritation of substances such as ethanol to the human body during use, resulting in a better skin feel.

[0024] 4. Medium-chain triglycerides or dioctyl carbonate are both very refreshing and non-greasy oils. They are combined with icolinercine, menthyl lactate or peppermint oil, and cosmetic-grade oil gel agents to make an oil gel. When applied to the skin, it feels comfortable, silky and cool, and has a better skin feel without being greasy.

[0025] 5. Adjusting the pH to 6.8-7.5 allows the carbomer solution to form a gel. This transforms the oil-in-water (O / W) gel emulsion prepared from solutions 1 and 2 into a gel emulsion, making the entire system more stable. Icaridin is less volatile, and it also neutralizes the weak acidity of carbomer. After stirring or shearing homogenization, the pH stabilizes at 5.5-6.5, which is close to the normal pH of the human body, further ensuring skin comfort.

[0026] 6. Oily gelling agents can thicken or semi-solidify the oil solution of icocaretine, greatly slowing down the volatilization of icocaretine and ensuring the sustained-release effect at the first level. 。The hydrophilic carboxylic acid groups of sodium octenyl succinate starch extend into the water, while the lipophilic octenyl long chains extend into the oil. At the oil-water interface, the large polysaccharide chains form a tough, unbreakable film, acting like a liner covering the icolinergic oil gel. This allows the emulsion to distribute on the skin in a microcapsule-like manner, preventing icolinergic evaporation and slowing down its volatilization. This second layer ensures the sustained-release effect. Carbomer is a white, loose powder with hygroscopic properties. Its aqueous solution, after alkali neutralization, forms an excellent gel matrix. In particular, 940 or 980 carbomer forms a transparent gel with good spreadability, commonly used in the production of cosmetic creams. It is non-toxic, non-irritating, easy to apply and adhere to, and has protective and UV-protective effects on the skin. It also has antibacterial properties. The adhesiveness and semi-solidity of the carbomer hydrogel act like another liner covering the oil-in-water gel, greatly slowing down the volatilization of icolinergic, thus ensuring the sustained-release effect.

[0027] 7. The final product is a hydrogel cream, which, from the inside out, presents the following characteristics: an oil gel, an oil gel coated with sodium octenyl succinate starch in the form of water-in-oil emulsion particles, and a carbomer hydrogel that encapsulates the water-in-oil gel emulsion into a gel emulsion. This allows for easy application, portability, and reduced waste.

[0028] 8. Triple combination sustained-release topical mosquito repellent has been proven by tests to have a significantly longer mosquito repellent effect than carbomer gel mosquito repellent and hydrogel molecular capsule-type topical mosquito repellent made by the combination of sodium starch octenyl succinate and carbomer. The mosquito repellent effect of the triple combination sustained-release mosquito repellent is significantly longer than that of ordinary mosquito repellent topical or spray products on the market.

[0029] 9. This method uses water as a matrix and emulsifies a pre-oil gel liquid at 40-55℃ to prepare an oil-in-water (O / W) emulsion. Then, at room temperature, the oil phase in the emulsion is thickened or semi-solidified into an oil gel to obtain an oil-in-water gel (O / W) emulsion. Finally, the emulsion is processed by carbomer to form a hydrogel to prepare an emulsion gel cream. This method overcomes the instability of oil-in-water (O / W) emulsions, making the system stable and convenient to carry and use.

[0030] 10. The topical mosquito repellent produced by this method uses only about 10% of the total mass of icolinergic agent, which is significantly lower than the 15-20% of existing technologies. The smaller amount of icolinergic agent not only helps to save costs, but also improves the safety of use.

[0031] This invention provides a triple-release topical mosquito repellent, the technical solution of which is as follows:

[0032] A triple-release topical mosquito repellent, wherein the weight content of each component in the topical mosquito repellent is as follows: 8-12% icosaretin, 1.37-1.72% medium-chain triglyceride or 1.37-1.72% dioctyl carbonate; 1.56-1.87% menthyl lactate or peppermint oil, 0.28-0.60% oily gelling agent, 0.31-0.36% sodium starch octenyl succinate, 0.05-0.06% potassium cinnamate, 0.65-0.70% carbomer, and the remainder is water.

[0033] Furthermore, the oily gelling agent may be selected from rice bran wax (0.52-0.60%), glyceryl monostearate (0.28-0.42%), or dextrin palmitate (0.45-0.50%).

[0034] Furthermore, the pH of topical insect repellents is 6.8-7.5.

[0035] Furthermore, the carbomer used is either the 940 or 980 type.

[0036] Further, after adjusting the pH value to 6.8-7.5, the mixture was sheared and homogenized at a speed of 1000-1500 r / m for 10 minutes.

[0037] The beneficial effects are:

[0038] 1. The addition of an oily gelling agent allows the triple-release, topical mosquito repellent to thicken or form a semi-solid oil gel at room temperature, greatly reducing the volatilization of icoplanin and effectively extending the mosquito-repelling time. In addition, the oil gel is not easily washed away by water, improving the product's water resistance.

[0039] 2. The components do not contain flammable and explosive organic solvents such as ethanol, and all components are recognized safe excipients of food or cosmetic grade, avoiding safety hazards in the production process and avoiding irritation to the human body by substances such as ethanol during use, resulting in a better skin feel.

[0040] 3. Medium-chain oils or dioctyl carbonate have a refreshing, non-greasy texture and are oil-based, effectively improving the skin feel and water resistance of the triple-release topical insect repellent. The addition of menthyl lactate or peppermint oil can make the skin feel cool and comfortable.

[0041] 4. Rice bran wax, glyceryl monostearate, and dextrin palmitate are all gelling agents that can form oleogels. They can be used as cosmetic grade gels, are non-irritating to the skin, and are safe and comfortable. In particular, when rice bran wax is used to prepare a semi-solid oleogel by mixing icocaritin with a mixed oil solution of menthol lactate or peppermint oil, medium-chain oil or dioctyl carbonate, it feels light, non-greasy, soft and silky when applied to the skin.

[0042] 5. Adjusting the pH to 6.8-7.5 allows the carbomer solution to form a gel. This transforms the oil-in-water (O / W) gel emulsion prepared from solutions 1 and 2 into a gel emulsion, making the entire system more stable. Icaridin is less volatile, and it also neutralizes the weak acidity of carbomer. After stirring or shearing homogenization, the pH stabilizes at 5.5-6.5, which is close to the normal pH of the human body, further ensuring skin comfort.

[0043] 6. The final product is a hydrogel cream, which, from the inside out, consists of: an oil gel, an oil gel coated with sodium octenyl succinate starch in the form of water-in-oil emulsion particles, and a carbomer hydrogel that encapsulates the water-in-oil gel emulsion into a gel emulsion. It can be applied, is easy to carry, and is not easily wasted.

[0044] 7. Triple-combination sustained-release topical mosquito repellent has been proven in tests to have a significantly longer mosquito-repellent duration than carbomer gel mosquito repellent and hydrogel molecular capsule-type topical mosquito repellent made by the combination of sodium starch octenyl succinate and carbomer. The mosquito-repellent duration of the triple-combination sustained-release mosquito repellent is significantly longer than that of ordinary mosquito repellent topical or spray products on the market.

[0045] 8. The amount of icolinergic in this topical insect repellent is only about 10% of the total mass, which is significantly lower than the 15-20% of existing technologies. The smaller amount of icolinergic not only saves costs but also improves safety.

Detailed Implementation Methods

[0046] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to the appendix.

[0047] Specific Example 1 of the preparation method of a triple-release topical mosquito repellent provided by the present invention:

[0048] The method for preparing a triple-release, topical mosquito repellent provided in this embodiment is as follows:

[0049] Icaridin is mixed with one of medium-chain oil and dioctyl carbonate, and one of menthyl lactate and peppermint oil in a certain proportion to prepare an iccaridin mixed oil solution. Then, one or a mixture of two of rice bran wax, glyceryl monostearate and dextrin palmitate are added in a certain proportion and stirred. The mixture is heated to 40-55℃ to prepare solution 1, which is then kept warm for later use.

[0050] Take sodium octenyl succinate starch and potassium cinnamate, add deionized water and stir, dissolve at 40-55℃ to obtain solution 2, keep warm for later use;

[0051] Take 940 or 980 type carbomer, add deionized water and stir or shear to homogenize, to obtain a semi-transparent solution 3, for later use.

[0052] Slowly add solution 1 to solution 2 which is kept at a temperature while stirring. After the solution is completely added, stir rapidly at a temperature of 40-55℃ for 20-30 minutes, let it cool naturally to room temperature, and then shear homogenize at a speed of 1000-1500r / m for 30 minutes to obtain an oil-in-water gel emulsion (O / W) for later use.

[0053] Stir or shear the homogenized solution 3, add the oil-in-water gel emulsion, and then shear and homogenize at 1000-1500 r / m for 30 minutes. Add a saturated sodium carbonate or sodium bicarbonate aqueous solution to adjust the pH to 6.8-7.5, and then shear and homogenize at 1000-1500 r / m for 10 minutes to obtain a triple-release topical mosquito repellent.

[0054] In the preparation of solution 1, when rice bran wax is used, its proportion in the total mass of solution 1 is 3-4.5%; when glyceryl monostearate is used, its proportion in the total mass of solution 1 is 2.0-3.0%; and when dextrin palmitate is used, its proportion in the total mass of solution 1 is 4.0-5.0%. When a rice bran wax-glyceryl monostearate mixture with a mass ratio of 2:1.5 is used, its proportion in the total mass of solution 1 is 2.5-3.5%; when a rice bran wax-dextrin palmitate mixture with a mass ratio of 2:1.2 is used, its proportion in the total mass of solution 1 is 3.5-4.5%; and when a glyceryl monostearate-dextrin palmitate mixture with a mass ratio of 2:1.2 is used, its proportion in the total mass of solution 1 is 3.0-3.5%.

[0055] When preparing the icocaretin mixed oil solution, icocaretin accounts for 77% of the total mass of the icocaretin mixed oil solution. If medium-chain oil and menthyl lactate are used, their proportions in the total mass of the icocaretin mixed oil solution are 12-12.5% ​​for menthyl lactate and 10.5-11% for medium-chain oil, respectively. If dioctyl carbonate and menthyl lactate are used, their proportions in the total mass of the icocaretin mixed oil solution are 12-13% for menthyl lactate and 10-11% for dioctyl carbonate, respectively.

[0056] When solution 1 cools naturally to below 30-35℃, it becomes a semi-solidified icoplanin oleogel. At room temperature, solution 1 forms an icoplanin oleogel, thus preventing the volatilization of icoplanin and prolonging the mosquito-repellent effect. Solution 1 is the oleogel phase, while solutions 2 and 3 are both aqueous phases.

[0057] When preparing solution 2, the proportions of sodium octenyl succinate starch and potassium cinnamate in the total mass are 0.51-0.55% and 0.08-0.10%, respectively.

[0058] In this embodiment, medium-chain triglycerides, menthyl lactate, and glyceryl monostearate were selected for preparing solution 1. Table 1 shows the feed ratio of the selected raw materials in the total mass of the triple-release topical insect repellent:

[0059]

[0060] Specifically, accurately weigh 50.05g of icolinergic acid, 7.8g of menthyl lactate and 6.9g of medium-chain triglyceride, place them in a 100ml single-necked flask, add a magnetic stir bar to mix well, add 1.4g of glyceryl monostearate, stir at 40-55℃ to dissolve into an oil solution, and keep warm for later use.

[0061] Weigh 171g of deionized water and place it in a 500ml three-necked flask. Add 1.6g of sodium octenyl succinate starch and 0.25g of potassium cinnamate while stirring. Dissolve the solution by stirring at 40-55℃. Slowly add the above oil solution to the solution while stirring at the same temperature. Stir rapidly at 40-55℃ for 20-30 minutes and then let it cool naturally to room temperature. Then, shear and homogenize at 1000-1500r / m for 30 minutes to obtain an oil-in-water gel emulsion (O / W) for later use.

[0062] Take 3.25g of 940 carbomer and place it in a 1L three-necked flask. Add about 245g of deionized water and stir and shear to dissolve it into a translucent solution. Continue stirring and shearing, and add the above oil-in-water emulsion (O / W) all at once. Then, shear and homogenize at a speed of 1000-1500r / m for 30 minutes. Adjust the pH to 7.2 with saturated sodium carbonate aqueous solution. Measure and add deionized water to make the total weight 500g. Stir well to obtain a cream containing 10% icolinergic acid.

[0063] In other embodiments, 8.6g of menthyl lactate and 7.7g of medium-chain triglycerides can be weighed, and 170g of deionized water can be added. While stirring, 1.7g of sodium octenyl succinate starch and 0.28g of potassium cinnamate can be added, along with 3.38g of 940 carbomer. Deionized water is added, and the pH is adjusted to 7.0 with a saturated sodium carbonate aqueous solution, bringing the total weight to 500g. The mixture is stirred until homogeneous to obtain a cream containing 10% icolinergic acid. Alternatively, 9.35g of menthyl lactate and 8.6g of medium-chain triglycerides can be selected, and 2.1g of glyceryl monostearate can be added. 171g of deionized water is added, and while stirring, 1.8g of sodium octenyl succinate starch and 0.30g of potassium cinnamate can be added. 3.50g of 940 carbomer is added, and deionized water is added, and the pH is adjusted to 6.9 with a saturated sodium bicarbonate aqueous solution, bringing the total weight to 500g. The mixture is stirred until homogeneous to obtain a cream containing 10% icolinergic acid.

[0064] Specific Example 2 of the preparation method of a triple-release topical mosquito repellent provided by the present invention:

[0065] In this embodiment, medium-chain triglycerides, menthyl lactate, and rice bran wax were selected for preparing solution 1. Table 2 shows the feeding ratio of the selected raw materials in the total mass percentage of the triple-release topical insect repellent in this embodiment.

[0066] Table 2

[0067]

[0068] Specifically, accurately weigh 50.05g of icolinergic acid, 7.8g of menthyl lactate and 6.9g of medium-chain triglyceride, place them in a 100ml single-necked flask, add a magnetic stir bar to mix well, add 2.6g of rice bran wax, stir at 40-55℃ to dissolve into an oil solution, and keep warm for later use.

[0069] Weigh 171g of deionized water and place it in a 500ml three-necked flask. Add 1.6g of sodium octenyl succinate starch and 0.25g of potassium cinnamate while stirring. Dissolve the solution by stirring at 40-55℃. Slowly add the above oil solution to the solution while stirring at the same temperature. Stir rapidly at 40-55℃ for 20-30 minutes and then let it cool naturally to room temperature. Then, shear and homogenize at 1000-1500r / m for 30 minutes to obtain an oil-in-water gel emulsion (O / W) for later use.

[0070] Take 3.25g of 940 carbomer and place it in a 1L three-necked flask. Add deionized water and stir and shear to dissolve it into a uniform, translucent solution. Continue stirring and shearing, then add the above oil-in-water gel emulsion (O / W) all at once. Then, shear and homogenize at a speed of 1000-1500r / m for 30 minutes. Adjust the pH to 7.0 with saturated sodium carbonate aqueous solution and add deionized water to bring the total weight to 500g. Stir well to obtain a cream containing 10% icolinergic acid.

[0071] In other embodiments, 8.6g of menthyl lactate and 7.7g of medium-chain triglycerides can be weighed, 2.80g of rice bran wax can be added, and 170g of deionized water can be added. While stirring, 1.7g of sodium octenyl succinate starch and 0.28g of potassium cinnamate can be added. Correspondingly, 3.38g of carbomer of type 940 can be weighed, and deionized water can be added to adjust the pH to 7.0 with a saturated sodium carbonate aqueous solution, so that the total weight is 500g. Stir well to obtain a cream containing 10% icolinergic acid. Alternatively, weigh 9.35g of menthyl lactate and 8.6g of medium-chain triglycerides, add 3.0g of rice bran wax and 169g of deionized water, and while stirring, add 1.8g of sodium octenyl succinate starch and 0.30g of potassium cinnamate. Correspondingly, weigh 3.50g of 940 type carbomer, add deionized water and adjust the pH to 6.9 with a saturated sodium bicarbonate aqueous solution, so that the total weight is 500g. Stir well to obtain a cream containing 10% icolinergic acid.

[0072] Specific Example 3 of the preparation method of a triple-release topical mosquito repellent provided by the present invention:

[0073] In this embodiment, medium-chain oil, menthyl lactate, and dextrin palmitate were selected for preparing solution 1. Table 3 shows the feeding ratio of the raw materials selected in this embodiment in the total mass percentage of the triple-release topical insect repellent:

[0074] Table 3

[0075]

[0076] Specifically, accurately weigh 50.05g of icolinergic acid, 7.8g of menthyl lactate and 6.9g of medium-chain triglyceride, place them in a 100ml single-necked flask, add a magnetic stir bar to mix well, add 2.25g of dextrin palmitate, stir at 40-55℃ to dissolve into an oil solution, and keep warm for later use.

[0077] Weigh 171.16g of deionized water and place it in a 500ml three-necked flask. Add 1.6g of sodium octenyl succinate starch and 0.25g of potassium cinnamate while stirring. Dissolve the solution by stirring at 40-55℃. Slowly add the above oil solution to the solution while stirring at the same temperature. Stir rapidly at 40-55℃ for 20-30 minutes and then let it cool naturally to room temperature. Then, shear and homogenize at 1000-1500r / m for 30 minutes to obtain an oil-in-water gel emulsion (O / W) for later use.

[0078] Take 3.25g of 940 carbomer and place it in a 1L three-necked flask. Add about 232g of deionized water until the total weight is 500g. Stir and shear to dissolve into a translucent solution. Continue stirring and shearing. Add the above oil-in-water gel emulsion (O / W) all at once. Then shear and homogenize at a speed of 1000-1500r / m for 30 minutes. Adjust the pH to 7.1 with saturated sodium carbonate aqueous solution. Measure and add deionized water until the total weight is 500g. Stir well to obtain a cream containing 10% icolinergic acid.

[0079] In other embodiments, 8.6g of menthyl lactate and 7.7g of medium-chain triglycerides can be weighed, 2.36g of dextrin palmitate can be added, and 170g of deionized water can be added. Under stirring, 1.7g of sodium octenyl succinate starch and 0.28g of potassium cinnamate can be added. Correspondingly, 3.38g of 940 type carbomer can be weighed, and deionized water can be added to adjust the pH to 7.2 with saturated sodium carbonate aqueous solution, so that the total weight is 500g. Stir well to obtain a cream containing 10% icolinergic acid. Alternatively, weigh 9.35g of menthyl lactate and 8.6g of medium-chain triglycerides, add 2.5g of dextrin palmitate and 170g of deionized water, and while stirring, add 1.8g of sodium octenyl succinate starch and 0.30g of potassium cinnamate. Correspondingly, weigh 3.50g of 940 type carbomer, add deionized water, and adjust the pH to 6.9 with a saturated sodium bicarbonate aqueous solution, so that the total weight is 500g. Stir well to obtain a cream containing 10% icolinergic acid.

[0080] Specific Example 4 of the preparation method of a triple-release topical mosquito repellent provided by the present invention:

[0081] In this embodiment, dioctyl carbonate, menthyl lactate, and glyceryl monostearate were selected for preparing solution 1. Table 4 shows the feeding ratio of the raw materials selected in this embodiment in the total mass percentage of the triple-release topical insect repellent:

[0082] Table 4

[0083]

[0084] Specifically, Accurately weigh 50.05g of icolinergic acid, 7.8g of menthyl lactate and 6.9g of dioctyl carbonate, place them in a 100ml single-necked flask, add a magnetic stir bar to mix well, add 1.4g of glyceryl monostearate, stir at 40-55℃ to dissolve into an oil solution, and keep warm for later use.

[0085] Weigh 171g of deionized water and place it in a 500ml three-necked flask. Add 1.6g of sodium octenyl succinate starch and 0.25g of potassium cinnamate while stirring. Dissolve the solution by stirring at 40-55℃. Slowly add the above oil solution to the solution while stirring at the same temperature. Stir rapidly at 40-55℃ for 20-30 minutes and then let it cool naturally to room temperature. Then, shear and homogenize at 1000-1500r / m for 30 minutes to obtain an oil-in-water gel emulsion (O / W) for later use.

[0086] Take 3.25g of 940 carbomer and place it in a 1L three-necked flask. Add about 242g of deionized water and stir and shear to dissolve it into a translucent solution. Continue stirring and shearing, and add the above oil-in-water gel emulsion (O / W) all at once. Then, shear and homogenize at a speed of 1000-1500r / m for 30 minutes. Adjust the pH to 7.2 with saturated sodium carbonate aqueous solution. Measure and add deionized water to make the total weight 500g. Stir well to obtain a cream containing 10% icolinergic acid.

[0087] In other embodiments, 8.6g of menthyl lactate, 7.7g of dioctyl carbonate, and 1.7g of glyceryl monostearate can be weighed and added to 170g of deionized water. While stirring, 1.7g of sodium octenyl succinate starch and 0.28g of potassium cinnamate can be added. Correspondingly, 3.38g of carbomer type 940 can be weighed, and deionized water can be added to adjust the pH to 7.0 with a saturated sodium carbonate aqueous solution, so that the total weight is 500g. The mixture is stirred evenly to obtain a cream containing 10% icolinergic acid. Alternatively, weigh 9.35g of menthyl lactate and 8.6g of dioctyl carbonate, add 2.1g of glyceryl monostearate and 171g of deionized water, and while stirring, add 1.8g of sodium octenyl succinate starch and 0.30g of potassium cinnamate. Correspondingly, weigh 3.50g of carbomer type 940, add deionized water, and adjust the pH to 6.9 with a saturated sodium bicarbonate aqueous solution, so that the total weight is 500g. Stir well to obtain a cream containing 10% icolinergic acid.

[0088] Specific Example 5 of the preparation method of a triple-release topical mosquito repellent provided by the present invention:

[0089] In this embodiment, dioctyl carbonate, menthyl lactate, and rice bran wax were selected for preparing solution 1. Table 5 shows the feeding ratio of the raw materials selected in this embodiment in the total mass percentage of the triple-release topical mosquito repellent:

[0090] Table 5

[0091]

[0092]

[0093] Specifically, accurately weigh 50.05g of icolinergic acid, 7.8g of menthyl lactate and 6.9g of dioctyl carbonate, place them in a 100ml single-necked flask, add a magnetic stir bar to mix well, add 2.6g of rice bran wax, stir at 40-55℃ to dissolve into an oil solution, and keep warm for later use.

[0094] Weigh 171g of deionized water and place it in a 500ml three-necked flask. Add 1.6g of sodium octenyl succinate starch and 0.25g of potassium cinnamate while stirring. Dissolve the solution by stirring at 40-55℃. Slowly add the above oil solution to the solution while stirring at the same temperature. Stir rapidly at 40-55℃ for 20-30 minutes and then let it cool naturally to room temperature. Then, shear and homogenize at 1000-1500r / m for 30 minutes to obtain an oil-in-water gel emulsion (O / W) for later use.

[0095] Take 3.25g of 940 carbomer and place it in a 1L three-necked flask. Add deionized water and stir and shear to dissolve it into a translucent solution. Continue stirring and shearing, and then add the above oil-in-water gel emulsion (O / W) all at once. However, in other embodiments, it can also be sheared and homogenized at a speed of 1000-1500r / m for 30 minutes, and the pH is adjusted to 7.0 with saturated sodium carbonate aqueous solution. Measure and add deionized water to make the total weight 500g, and stir evenly to obtain a cream containing 10% icolinergic acid.

[0096] In other embodiments, 8.6g of menthyl lactate, 7.7g of dioctyl carbonate, and 2.80g of rice bran wax can be weighed and added to 170g of deionized water. While stirring, 1.7g of sodium octenyl succinate starch and 0.28g of potassium cinnamate can be added. Correspondingly, 3.38g of carbomer of type 940 can be weighed, and deionized water can be added to adjust the pH to 7.0 with a saturated sodium carbonate aqueous solution, so that the total weight is 500g. Stir well to obtain a cream containing 10% icolinergic acid. Alternatively, weigh 9.35g of menthyl lactate and 8.6g of dioctyl carbonate, add 3.0g of rice bran wax and 169g of deionized water, and while stirring, add 1.8g of sodium octenyl succinate starch and 0.30g of potassium cinnamate. Correspondingly, weigh 3.50g of carbomer type 940, add approximately 239g of deionized water, add deionized water and adjust the pH to 6.9 with a saturated sodium bicarbonate aqueous solution, so that the total weight is 500g. Stir evenly to obtain a cream containing 10% icolinergic acid.

[0097] Specific Example 6 of the preparation method of a triple-release topical mosquito repellent provided by the present invention:

[0098] In this embodiment, dioctyl carbonate, menthyl lactate, and dextrin palmitate were selected for preparing solution 1. Table 6 shows the feeding ratio of the raw materials selected in this embodiment in the total mass percentage of the triple-release topical mosquito repellent:

[0099]

[0100] Specifically, accurately weigh 50.05g of icolinergic acid, 7.8g of menthyl lactate and 6.9g of dioctyl carbonate, place them in a 100ml single-necked flask, add a magnetic stir bar to mix well, add 2.25g of dextrin palmitate, stir at 40-55℃ to dissolve into an oil solution, and keep warm for later use.

[0101] Weigh 171.16g of deionized water and place it in a 500ml three-necked flask. Add 1.6g of sodium octenyl succinate starch and 0.25g of potassium cinnamate while stirring. Dissolve the solution by stirring at 40-55℃. Slowly add the above oil solution to the solution while stirring at the same temperature. Stir rapidly at 40-55℃ for 20-30 minutes and then let it cool naturally to room temperature. Then, shear and homogenize at 1000-1500r / m for 30 minutes to obtain an oil-in-water gel emulsion (O / W) for later use.

[0102] Take 3.25g of 940 carbomer and place it in a 1L three-necked flask. Add deionized water and stir and shear to dissolve it into a translucent solution. Continue stirring and shearing, and add the above oil-in-water gel emulsion (O / W) all at once. Then, shear and homogenize at a speed of 1000-1500r / m for 30 minutes. Adjust the pH to 7.2 with saturated sodium carbonate aqueous solution. Measure and add deionized water to make the total weight 500g. Stir well to obtain a cream containing 10% icolinergic acid.

[0103] In other embodiments, 8.6g of menthyl lactate and 7.7g of dioctyl carbonate can be weighed, 2.36g of dextrin palmitate can be added, and 170g of deionized water can be added. While stirring, 1.7g of sodium octenyl succinate starch and 0.28g of potassium cinnamate can be added. Correspondingly, 3.38g of 940 type carbomer can be weighed, and deionized water can be added to adjust the pH to 7.0 with saturated sodium carbonate aqueous solution, so that the total weight is 500g. Stir well to obtain a cream containing 10% icolinergic acid. Alternatively, weigh 9.35g of menthyl lactate and 8.6g of dioctyl carbonate, add 2.5g of dextrin palmitate and 169g of deionized water, and while stirring, add 1.8g of sodium octenyl succinate starch and 0.30g of potassium cinnamate. Correspondingly, weigh 3.50g of 940 type carbomer, add deionized water and adjust the pH to 7.0 with saturated sodium bicarbonate aqueous solution, so that the total weight is 500g. Stir evenly to obtain a cream containing 10% icolinergic acid.

[0104] Specific Example 7 of the preparation method of a triple-release topical mosquito repellent provided by the present invention:

[0105] In this embodiment, peppermint oil, medium-chain triglycerides and glyceryl monostearate were selected, and carbomer of type 980 was selected.

[0106] Specifically, accurately weigh 50.05g of icolinergic acid, 8.6g of peppermint oil and 7.7g of medium-chain triglycerides, place them in a 100ml single-necked flask, stir with a magnetic stir bar to mix well, add 1.7g of glyceryl monostearate, stir at 40-55℃ to dissolve into an oil solution, and keep warm for later use.

[0107] Weigh 170g of deionized water and place it in a 500ml three-necked flask. Add 1.7g of sodium octenyl succinate starch and 0.28g of potassium cinnamate while stirring. Dissolve the solution by stirring at 40-55℃. Slowly add the above oil solution to the solution while stirring at the same temperature. Stir rapidly at 40-55℃ for 20-30 minutes and then let it cool naturally to room temperature. Then, shear and homogenize at 1000-1500r / m for 30 minutes to obtain an oil-in-water gel emulsion (O / W) for later use.

[0108] Take 3.38g of 980 carbomer and place it in a 1L three-necked flask. Add deionized water and stir and shear to dissolve it into a translucent solution. Continue stirring and shearing, and add the above oil-in-water gel emulsion (O / W) all at once. Then, shear and homogenize at a speed of 1000-1500r / m for 30 minutes. Adjust the pH to 7.1 with saturated sodium bicarbonate aqueous solution, and add deionized water to a total weight of 500g. Stir well to obtain a cream containing 10% icolinergic acid.

[0109] In other embodiments, 8.6g of menthyl lactate and 7.7g of medium-chain triglycerides can be weighed, 2.80g of rice bran wax can be added, and 170g of deionized water can be added. While stirring, 1.7g of sodium octenyl succinate starch and 0.28g of potassium cinnamate can be added. Correspondingly, 3.38g of carbomer of type 980 can be weighed, and deionized water can be added. The pH can be adjusted to 7.0 with saturated sodium carbonate aqueous solution, and then deionized water can be added until the total weight is 500g. The mixture can be stirred evenly to obtain a cream containing 10% icolinergic acid. Alternatively, weigh 8.6g of menthyl lactate and 7.7g of medium-chain triglycerides, add 2.36g of dextrin palmitate and 170g of deionized water, and while stirring, add 1.7g of sodium octenyl succinate starch and 0.28g of potassium cinnamate. Correspondingly, weigh 3.38g of carbomer type 980, add deionized water, adjust the pH to 7.0 with saturated sodium bicarbonate aqueous solution, and add deionized water to a total weight of 500g. Stir well to obtain a cream containing 10% icolinergic acid.

[0110] Specific Example 8 of the preparation method of a triple-release topical mosquito repellent provided by the present invention:

[0111] In this embodiment, menthyl lactate, dioctyl carbonate and glyceryl monostearate are selected, and carbomer of type 980 is selected.

[0112] The difference between this embodiment and Embodiment 1 is that 50.05g of icolinergic acid, 8.6g of menthyl lactate and 7.7g of dioctyl carbonate were accurately weighed and placed in a 100ml single-necked flask. The mixture was stirred with a magnetic stir bar and mixed well. 1.7g of glyceryl monostearate was added and stirred at 40-55℃ to dissolve it into an oil solution. The solution was kept warm for later use.

[0113] Weigh 170g of deionized water and place it in a 500ml three-necked flask. Add 1.7g of sodium octenyl succinate starch and 0.28g of potassium cinnamate while stirring. Dissolve the solution by stirring at 40-55℃. Slowly add the above oil solution to the solution while stirring at the same temperature. Stir rapidly at 40-55℃ for 20-30 minutes and then let it cool naturally to room temperature. Then, shear and homogenize at 1000-1500r / m for 30 minutes to obtain an oil-in-water gel emulsion (O / W) for later use.

[0114] Take 3.38g of 980 type carbomer and place it in a 1L three-necked flask. Add deionized water and stir and shear to dissolve it into a translucent solution. Continue stirring and shearing, and add the above oil-in-water gel emulsion (O / W) all at once. Then, shear and homogenize at a speed of 1000-1500r / m for 30 minutes. Adjust the pH to 7.0 with saturated sodium carbonate aqueous solution, and then add deionized water to a total weight of 500g. Stir well to obtain a cream containing 10% icolinergic acid.

[0115] In other embodiments, 8.6g of menthyl lactate and 7.7g of dioctyl carbonate can be weighed, 2.80g of rice bran wax can be added, and 170g of deionized water can be added. While stirring, 1.7g of sodium octenyl succinate starch and 0.28g of potassium cinnamate can be added. Correspondingly, 3.38g of carbomer type 980 can be weighed, and deionized water can be added. The pH can be adjusted to 7.0 with saturated sodium carbonate aqueous solution, and then deionized water can be added to a total weight of 500g. The mixture can be stirred evenly to obtain a cream containing 10% icolinergic acid. Alternatively, weigh 8.6g of menthyl lactate and 7.7g of medium-chain triglycerides, add 2.36g of dextrin palmitate and 170g of deionized water, and while stirring, add 1.7g of sodium octenyl succinate starch and 0.28g of potassium cinnamate. Correspondingly, weigh 3.38g of carbomer type 980, add deionized water, adjust the pH to 7.0 with saturated sodium bicarbonate aqueous solution, and then add deionized water to a total weight of 500g. Stir well to obtain a cream containing 10% icolinergic acid.

[0116] Specific embodiment 1 of a triple-release topical mosquito repellent provided by the present invention:

[0117] The triple-release topical mosquito repellent provided in this embodiment is the triple-release topical mosquito repellent described in any one of the specific embodiments 1-8 of the preparation method of the triple-release topical mosquito repellent provided by the present invention.

[0118] A comparative test was conducted to compare the duration of effectiveness of topical mosquito repellents with that of existing gel-type and hydrogel capsule-type topical mosquito repellents, using the time before mosquitoes began to bite as the standard.

[0119] The preparation method of the gel-type mosquito repellent is as follows: accurately weigh 50.05g of icolinergic acid and 8.6g of menthyl lactate, place them in a 100ml single-necked flask, and stir with a magnetic stir bar to dissolve them into a solution for later use; take 0.28g of potassium cinnamate and 3.5g of 940 carbomer, place them in a 1L flask, add deionized water to a total weight of 450g, stir and shear to dissolve into a semi-transparent solution, continue stirring and shearing, add the above icolinergic acid-menthyl lactate mixed solution all at once, and then shear homogenize at a speed of 1000-1500r / m for 30 minutes, adjust the pH to 7.0 with saturated sodium carbonate aqueous solution, and add water to a total weight of 500g, stir evenly to obtain a semi-cured gel containing 10% icolinergic acid.

[0120] The preparation method of the hydrogel molecular capsule-type mosquito repellent is as follows: Accurately weigh 50.05g of icolinergic acid, 8.6g of menthyl lactate, and 7.7g of medium-chain triglyceride into a 100ml single-necked flask, and stir with a magnetic stirrer to dissolve them into a solution for later use; weigh 170g of deionized water into a 500ml three-necked flask, and add 1.7g of sodium octenyl succinate starch and 0.28g of potassium cinnamate while stirring, and stir to dissolve into a transparent solution; continue stirring and add the above-prepared icolinergic acid-menthyl lactate-medium-chain triglyceride solution all at once, and then stir at 1000-1500 rpm. Shear homogenize at a speed of 1000-1500 r / m for 30 minutes to obtain an oil-in-water emulsion, set aside; take 3.5 g of 940 carbomer, place it in a 1 L flask, add deionized water to a total weight of 450 g, stir and shear to dissolve into a translucent solution, add the above oil-in-water emulsion (O / W) all at once while stirring and shearing, then shear homogenize at a speed of 1000-1500 r / m for 30 minutes, adjust the pH to 7.0 with saturated sodium carbonate aqueous solution, add water to a total weight of 500 g, stir evenly to obtain a semi-solid hydrogel molecular capsule type mosquito repellent containing 10% icoplanin.

[0121] The field group experiment protocol is as follows:

[0122] First, the experimental groups were divided into three groups. The first group was a comparison between hydrogel molecular capsule-type topical mosquito repellent and gel-type mosquito repellent, consisting of three people. The second group was a comparison between triple-release topical mosquito repellent and hydrogel molecular capsule-type topical mosquito repellent, consisting of three people. The third group was a comparison between triple-release topical mosquito repellent prepared with menthyl lactate and medium-chain oil and triple-release topical mosquito repellent prepared with menthyl lactate and dioctyl carbonate, consisting of three people.

[0123] Two different repellents were applied in equal amounts to the bare lower legs (below the knees and above the ankles) of each group for testing. Other areas were covered with clothing, shoes, and socks. The test ended when the first mosquito bite was detected. The results are shown in the table below:

[0124] Table 7: Comparison of Hydrogel Molecular Capsule-type Topical Mosquito Repellent and Gel-type Mosquito Repellent

[0125]

[0126] Note: Apply hydrogel capsule-type mosquito repellent to the left leg; apply gel-type mosquito repellent to the right leg.

[0127] According to Table 7, the effective duration of 10% icocaretin hydrogel capsule-type mosquito repellent is approximately 7-8 hours; the effective duration of 10% icocaretin gel-type mosquito repellent is approximately 4-5 hours.

[0128] Table 8: Comparison results of topical mosquito repellent and hydrogel capsule-type mosquito repellent in this embodiment.

[0129]

[0130] Note: Apply the triple-release medium-chain oil-based mosquito repellent of this invention to the left leg; apply the hydrogel-type mosquito repellent to the right leg.

[0131] According to Table 8, the effective time of the 10% icocaretin triple sustained-release mosquito repellent of the present invention is about 9-10 hours, and the effective time of the 10% icocaretin hydrogel molecular capsule type topical mosquito repellent is about 7-8 hours.

[0132] Table 9: Comparison of repellents between the icolinergic-menthyl lactate-medium chain oil system and the icolinergic-menthyl lactate-dioctyl carbonate system.

[0133]

[0134] Note: Apply icolinerc-menthol lactate-medium chain oil system long-lasting repellent to the left leg, and icolinerc-menthol lactate-dioctyl carbonate system repellent to the right leg.

[0135] According to Table 9, the mosquito repellent duration of the medium-chain oil system and the dioctyl carbonate system of the 10% icosate triple sustained-release mosquito repellent of the present invention is comparable, both being approximately 9-10 hours.

[0136] Field mosquito repellent experiments show that using sodium octenyl succinate starch and oleogels can indeed increase the duration of mosquito repellent effect by reducing the volatilization of icocarbetine, and the increase is significant. This indicates that the formulation design of the present invention can indeed achieve the purpose and effect of slow-release mosquito repellent.

Claims

1. A method for preparing a triple-release topical mosquito repellent, characterized in that, The method for preparing the mosquito repellent is as follows: Icaridin is mixed with one of medium-chain oil and dioctyl carbonate, one of menthyl lactate and peppermint oil in a certain proportion to prepare an iccaridin mixed oil solution. Then, at least one of rice bran wax, glyceryl monostearate and dextrin palmitate is added in a certain proportion and mixed and stirred. The mixture is heated to 40-55℃ to prepare solution 1, which is kept warm for later use. Take sodium octenyl succinate starch and potassium cinnamate, add deionized water and stir, dissolve at 40-55℃ to prepare solution 2, keep warm for later use; Take carbomer, add deionized water and stir or shear to dissolve it into a semi-transparent solution 3, for later use. Slowly add solution 1 to solution 2, which is kept at a constant temperature, while stirring. After the solution is completely added, allow it to cool naturally to room temperature at 40-55°C. Then, stir or shear to homogenize the solution to obtain an oil-in-water gel emulsion for later use. Stir or shear homogenize solution 3, add oil-in-water gel emulsion, stir or shear homogenize, adjust the pH to 6.8-7.5, stir or shear homogenize again to obtain the triple-release topical mosquito repellent.

2. The method for preparing a triple-release topical mosquito repellent according to claim 1, characterized in that, The carbomer used is either type 940 or 980.

3. The method for preparing a triple-release topical mosquito repellent according to claim 2, characterized in that, When solution 1 is slowly added to solution 2 which is kept at a constant temperature, the mixture is sheared and homogenized at a speed of 1000-1500 r / m for 30 minutes to obtain an oil-in-water gel emulsion.

4. The method for preparing a triple-release topical mosquito repellent according to claim 3, characterized in that, When homogenizing solution 3 by stirring or shearing, shear homogenize at a speed of 1000-1500 r / m for 30 minutes, then adjust the pH value to 6.8-7.5, and then shear homogenize at a speed of 1000-1500 r / m for 10 minutes or stir for 15-20 minutes.

5. The method for preparing a triple-release topical mosquito repellent according to claim 4, characterized in that, When stirring or shearing homogenized solution 3, add saturated sodium carbonate or sodium bicarbonate aqueous solution to adjust the pH to 6.8-7.

5.

6. A triple-release topical insect repellent, characterized in that, The weight percentages of each component in the topical mosquito repellent are as follows: 8-12% icosate, 1.37-1.72% medium-chain triglyceride or 1.37-1.72% dioctyl carbonate; 1.56-1.87% menthyl lactate or peppermint oil; 0.28-0.60% oily gelling agent; 0.31-0.36% sodium starch octenyl succinate; 0.05-0.06% potassium cinnamate; 0.65-0.70% carbomer; and the remainder is water.

7. The triple-release topical insect repellent according to claim 6, characterized in that, The oily gelling agent is selected from rice bran wax (0.52-0.60%), glyceryl monostearate (0.28-0.42%), or dextrin palmitate (0.45-0.50%).

8. The triple-release topical insect repellent according to claim 7, characterized in that, The pH of topical insect repellents is 6.8-7.

5.

9. The triple-release topical insect repellent according to claim 8, characterized in that, The carbomer should be either type 940 or 980.

10. The method for preparing a triple-release topical mosquito repellent according to claim 10, characterized in that, After adjusting the pH value to 6.8-7.5, shear and homogenize at a speed of 1000-1500 r / m for 10 minutes.

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