Coenzyme Q10 oral liquid and preparation method thereof
Patent Information
- Application Number
- CN202611426652.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-09-15
- Publication Date
- 2026-10-23
AI Technical Summary
通过辛烯基琥珀酸淀粉钠（主乳化剂）与吐温80、聚甘油脂肪酸酯（复配辅助乳化剂）协同作用，形成纳米级乳化体系，将脂溶性的辅酶Q10高度分散于水相中，有效克服了其极难溶于水的固有缺陷，显著提升了辅酶Q10的水溶性与分散稳定性；结合羧甲基纤维素钠作为增稠稳定剂，与辛烯基琥珀酸淀粉钠共同构建三维网络结构，延缓颗粒沉降，确保口服液在长期储存中保持均一、不分层、不沉淀；
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Abstract
Description
Technical Field
[0001] This application belongs to the field of health food processing technology, and in particular relates to a coenzyme Q10 oral liquid and its preparation method. Background Technology
[0002] Coenzyme Q10 (also known as ubiquinone) is a lipid-soluble quinone compound widely found in organisms. It plays a core regulatory role in cellular energy metabolism and possesses potent antioxidant activity, capable of scavenging free radicals and protecting cell membrane integrity. Due to its excellent physiological functions, coenzyme Q10 has been widely used in the food, health supplement, and pharmaceutical industries.
[0003] However, the inherent physicochemical properties of coenzyme Q10 limit its industrial application in oral formulations: firstly, as a typical fat-soluble substance, it has extremely poor water solubility, making it difficult to directly prepare into a homogeneous and stable emulsion-type oral liquid formulation; secondly, its chemical structure contains unsaturated bonds, making it prone to oxidative degradation under conditions such as light, high temperature, and oxygen, resulting in poor stability and directly affecting the quality and shelf life of the formulation.
[0004] Existing technologies for improving coenzyme Q10 formulations are mostly limited to the application of a single emulsifier or simple adjustments to the formulation form (such as capsules or tablets), but solid dosage forms lack the convenience of administration; some oral liquid formulations also exhibit significant stability defects, easily leading to stratification and precipitation during storage, and the coenzyme Q10 content decreases significantly with storage time. Therefore, developing oral liquid formulations that can simultaneously address the poor water solubility and instability of coenzyme Q10 has significant practical value and market potential. Summary of the Invention
[0005] The purpose of this application is to provide a coenzyme Q10 oral liquid and its preparation method to solve the technical problems of existing coenzyme Q10 products, such as poor water solubility, poor dispersion stability, single dosage form, and low patient compliance.
[0006] To achieve the above objectives, the technical solution adopted in this application is as follows: A coenzyme Q10 oral solution, comprising, by weight: 0.2-0.6 parts coenzyme Q10, 1.2-2 parts sodium octenyl succinate starch, 0.1-0.3 parts Tween 80, 0.5-2 parts polyglycerol fatty acid ester, 0.15-0.3 parts sodium carboxymethyl cellulose, 8-12 parts glycerol, 6-9 parts fructooligosaccharides, 0.2-0.3 parts caprylic acid glyceride, 0.2-0.3 parts decanoic acid glyceride, 0.08-0.18 parts citric acid, 0.1-0.25 parts edible flavoring, with the remainder being purified water.
[0007] In one embodiment, By weight, it includes: 0.3 parts coenzyme Q10, 1.2 parts sodium octenyl succinate starch, 0.2 parts Tween 80, 1.5 parts polyglycerol fatty acid esters, 0.15 parts sodium carboxymethyl cellulose, 10 parts glycerol, 7.5 parts fructooligosaccharides, 0.25 parts caprylic acid glyceride, 0.25 parts caprylic acid glyceride, 0.15 parts citric acid, 0.15 parts food flavoring, and the balance being purified water.
[0008] In one embodiment, By weight, it includes: 0.5 parts coenzyme Q10, 1.8 parts sodium octenyl succinate starch, 0.1 parts Tween 80, 0.8 parts polyglycerol fatty acid ester, 0.2 parts sodium carboxymethyl cellulose, 8 parts glycerol, 6 parts fructooligosaccharides, 0.2 parts caprylic acid glyceride, 0.2 parts caprylic acid glyceride, 0.12 parts citric acid, 0.12 parts food flavoring, and the balance being purified water.
[0009] This application also provides a method for preparing coenzyme Q10 oral liquid, specifically including the following steps: (a) Add sodium octenyl succinate starch, sodium carboxymethyl cellulose, fructooligosaccharides, and citric acid to a portion of purified water and mix to form an aqueous solution; (ii) Mix coenzyme Q10, caprylic acid glyceride, and caprylic acid glyceride, and heat and stir to dissolve to form an oil phase solution; (iii) Tween 80, polyglycerol fatty acid ester, and glycerol are added to a portion of purified water and stirred to prepare an emulsifier mixture; (iv) The aqueous solution and the oil solution are mixed, and the emulsifier mixture is added and stirred to form a primary emulsion; the primary emulsion is homogenized and cooled, and edible flavoring and purified water are added; after filling, sterilization and cooling, coenzyme Q10 oral solution is obtained.
[0010] In one embodiment, Step (1): Add purified water in an amount that is 40-50% of the total volume.
[0011] In one embodiment, In step (1), the mixing temperature of sodium octenyl succinate starch, sodium carboxymethyl cellulose, and fructooligosaccharides is 50-60 ℃, and the stirring speed is 300-500 r / min; the temperature is lowered to 20-25 ℃ before adding the citric acid.
[0012] In one embodiment, The heating temperature in step (ii) is 45-55 ℃, and the stirring speed is 200-300 r / min.
[0013] In one embodiment, The stirring speed in step (iii) is 400-600 r / min, and the stirring time is 5-10 min.
[0014] In one embodiment, Step (iv) The mixing speed of the aqueous solution and the oil solution is 800-1200 r / min; the homogenization pressure is 20-30 MPa, the number of homogenizations is 2-3, and the homogenization time is 5-10 min.
[0015] In one embodiment, The sterilization temperature in step (iv) is 80-100 ℃ and the time is 20-30 min.
[0016] This application provides a coenzyme Q10 oral liquid and its preparation method, which has the following advantages compared with the prior art: By synergistically combining sodium octenyl succinate starch (the primary emulsifier) with Tween 80 and polyglycerol fatty acid esters (compound auxiliary emulsifiers), a nanoscale emulsification system is formed, which highly disperses the fat-soluble coenzyme Q10 in the aqueous phase, effectively overcoming its inherent defect of being extremely difficult to dissolve in water, and significantly improving the water solubility and dispersion stability of coenzyme Q10. Combined with sodium carboxymethyl cellulose as a thickening and stabilizing agent, it works with sodium octenyl succinate starch to construct a three-dimensional network structure, delaying particle sedimentation and ensuring that the oral liquid remains homogeneous, does not separate, and does not precipitate during long-term storage. The formula incorporates citric acid to precisely control the system's pH, inhibiting the oxidative degradation of coenzyme Q10 in a weakly acidic environment. Caprylic and caprylic glycerides are used as oil-phase solvents, which not only rapidly dissolve coenzyme Q10 but also provide some antioxidant protection. Sodium octenyl succinate starch and sodium carboxymethyl cellulose synergistically thicken and prevent sedimentation. Tween 80 is combined with polyglycerol fatty acid esters to reduce oil-water interfacial tension, decrease the amount of single emulsifier used, and reduce the risk of irritation. Caprylic / caprylic glycerides act as both solvents and absorption enhancers, balancing formulation stability and bioavailability. Glycerin has both moisturizing and solubilizing effects, while fructooligosaccharides, in addition to sweetness, are beneficial to intestinal health, greatly improving the chemical stability and activity retention of coenzyme Q10, effectively extending the product's shelf life, and achieving multiple functional benefits. All excipients are food-grade or permitted for addition to health foods, ensuring safety and non-toxicity. The process employs a stepwise mixing of aqueous phase, oil phase, and emulsifier, combined with high-pressure homogenization. Parameters such as temperature, rotation speed, time, and homogenization pressure at each step are clearly controllable, ensuring batch-to-batch stability. Key parameters in the process are compatible with conventional food production equipment, requiring no special or expensive instruments, making it easy to operate and suitable for large-scale industrial production. The component ratios can be scaled up or down proportionally according to target yield, flexibly adapting to different production scales. The dosage form is an oral liquid, which, compared to solid dosage forms such as capsules and tablets, is easier to swallow and absorbs more quickly, making it especially suitable for the elderly, children, and those with swallowing difficulties.
[0017] In summary, this application simultaneously overcomes the two major technical bottlenecks of poor water solubility and poor stability of Coenzyme Q10 oral liquid, and provides a Coenzyme Q10 oral liquid with high stability, good taste, good safety, simple process and controllable cost and its preparation method. It solves the common problems of traditional preparations being easy to separate, easy to degrade and inconvenient to take, and provides a new technical idea for the development of liquid preparations of fat-soluble active ingredients. It has good practical value and significant market competitiveness. Detailed Implementation
[0018] To make the technical problems, technical solutions, and beneficial effects to be solved by this application clearer, this application will be further described in detail. It should be understood that the specific embodiments described herein are only for explaining this application and are not intended to limit this application.
[0019] Example 1 This embodiment provides a method for preparing a highly stable Coenzyme Q10 oral solution. Based on the preparation of 1000L of finished product, the weight proportions of each component are as follows: 5 kg Coenzyme Q10, 12 kg sodium octenyl succinate starch, 3 kg Tween 80, 15 kg polyglycerol fatty acid ester, 2 kg sodium carboxymethyl cellulose, 100 kg glycerol, 75 kg fructooligosaccharides, 2.5 kg caprylic acid glyceride, 2.5 kg caprylic acid glyceride, 1.5 kg citric acid, 1.5 kg lemon flavoring, and purified water to a final volume of 1000 L. Of the above components, Coenzyme Q10 is the core active ingredient, playing a role in regulating energy metabolism and antioxidation; sodium octenyl succinate starch is the main emulsifier and thickener, encapsulating Coenzyme Q10 to form nano-sized emulsion particles, increasing the viscosity of the system and preventing stratification; Tween 80 and polyglycerol fatty acid esters are compound auxiliary emulsifiers, reducing oil-water interfacial tension and enhancing dispersion; sodium carboxymethyl cellulose is a thickener and stabilizer, forming a three-dimensional network structure to delay particle sedimentation, and synergistically improving stability with sodium octenyl succinate starch; glycerol is a humectant and co-solvent, reducing water evaporation and helping to improve the solubility of components; fructooligosaccharides are a low-calorie sweetener, improving taste, and also having moisturizing and shelf-life-extending effects; caprylic and caprylic glycerides are food-grade oil phase solvents, rapidly dissolving Coenzyme Q10 and promoting its intestinal absorption; citric acid controls the pH at 4.0-5.0, inhibiting Coenzyme Q10 oxidation and optimizing taste; and food flavoring masks unpleasant odors and improves user compliance.
[0020] The preparation steps are as follows: (a) After uniformly dispersing 12 kg of sodium octenyl succinate starch, 2 kg of sodium carboxymethyl cellulose and 75 kg of oligofructose, put them into a premixing tank, add 450 L of purified water, heat to 55 ℃, stir at 400 r / min until completely dissolved, cool to 22 ℃, then add 1.5 kg of citric acid, stir until all components are completely dissolved, and form a homogeneous aqueous solution for later use. (ii) Add 5 kg of coenzyme Q10, 2.5 kg of caprylic acid glyceride and 2.5 kg of caprylic acid glyceride to another mixing tank. Place the contents of the tank in a 48 ℃ constant temperature water bath and stir continuously at 250 r / min until the coenzyme Q10 is completely dissolved to obtain a homogeneous oil phase solution for later use. (III) Add 100 kg of glycerol, 3 kg of Tween 80 and 15 kg of polyglycerol fatty acid ester to the premix tank, add 100 L of purified water, control the stirring speed at 500 r / min, and continue stirring for 8 min to obtain a homogeneous emulsifier mixture for later use. (iv) Slowly add the oil phase solution to the aqueous phase solution while stirring at 1000 r / min. After the addition is complete, continue stirring for 5 min, then add the emulsifier mixture and continue stirring for 18 min to form a homogeneous pre-emulsion. Transfer the pre-emulsion to a high-pressure homogenizer and homogenize twice at 25 MPa for 8 min each time. Set aside. After homogenization, allow the emulsion to cool naturally to 22 ℃, add 1.5 kg of lemon flavoring, and stir at 400 r / min for 8 min until the flavoring is evenly dispersed. Adjust the volume with the remaining purified water and continue stirring for 5 min to ensure the system is homogeneous. Fill the oral solution to 10 ml sterile glass bottles through a sterile filling line and seal them. Then place them in a water bath sterilizer and sterilize at 90 ℃ for 25 min. After sterilization, remove and allow to cool naturally to room temperature to obtain coenzyme Q10 oral solution.
[0021] Example 2 This embodiment provides a method for preparing a highly stable Coenzyme Q10 oral solution. Based on the preparation of 1000L of finished product, the weight proportions of each component are as follows: 3 kg Coenzyme Q10, 15 kg sodium octenyl succinate starch, 2 kg Tween 80, 10 kg polyglycerol fatty acid ester, 3 kg sodium carboxymethyl cellulose, 80 kg glycerol, 60 kg fructooligosaccharides, 2 kg caprylic acid glyceride, 2 kg caprylic acid glyceride, 1.2 kg citric acid, 1.2 kg sweet orange flavoring, and purified water to a final volume of 1000 L. The preparation steps are as follows: (a) Disperse 15 kg of sodium octenyl succinate starch, 3 kg of sodium carboxymethyl cellulose and 60 kg of oligofructose evenly and put them into a premixing tank. Add 400 L of purified water, heat to 50 ℃, stir at 300 r / min until completely dissolved, cool to 20 ℃, then add 1.2 kg of citric acid and stir until all components are completely dissolved to form a homogeneous aqueous solution for later use. (ii) Add 3 kg of coenzyme Q10, 2 kg of caprylic glyceride and 2 kg of caprylic glyceride to another mixing tank. Place the contents of the tank in a 45 ℃ constant temperature water bath and stir continuously at 200 r / min until the coenzyme Q10 is completely dissolved to obtain a homogeneous oil phase solution for later use. (III) Add 80 kg of glycerol, 2 kg of Tween 80 and 10 kg of polyglycerol fatty acid ester to the premix tank, add 100 L of purified water, control the stirring speed at 400 r / min, and continue stirring for 10 min to obtain a homogeneous emulsifier mixture for later use. (iv) Slowly add the oil phase solution to the aqueous phase solution while stirring at 800 r / min. After the addition is complete, continue stirring for 5 min, then add the emulsifier mixture and continue stirring for 20 min to form a homogeneous pre-emulsion. Transfer the pre-emulsion to a high-pressure homogenizer and homogenize it three times at 20 MPa for 5 min each time. Set aside. After homogenization, allow the emulsion to cool naturally to 20 ℃, add 1.2 kg of sweet orange flavoring, and stir at 300 r / min for 10 min until the flavoring is evenly dispersed. Adjust the volume with the remaining purified water and continue stirring for 5 min to ensure the system is homogeneous. Fill the oral solution to 10 ml sterile glass bottles through a sterile filling line and seal them. Then place them in a water bath sterilizer and sterilize them at 80 ℃ for 30 min. After sterilization, remove them and allow them to cool naturally to room temperature to obtain the Coenzyme Q10 oral solution.
[0022] Example 3 This embodiment provides a method for preparing a highly stable Coenzyme Q10 oral solution. Based on the preparation of 1000L of finished product, the weight proportions of each component are as follows: 6 kg Coenzyme Q10, 20 kg sodium octenyl succinate starch, 1 kg Tween 80, 8 kg polyglycerol fatty acid ester, 1.5 kg sodium carboxymethyl cellulose, 120 kg glycerol, 90 kg fructooligosaccharides, 3 kg caprylic acid glyceride, 3 kg caprylic acid glyceride, 1.8 kg citric acid, 1.8 kg strawberry flavoring, and purified water to a final volume of 1000 L. The preparation steps are as follows: (a) Disperse 20 kg of sodium octenyl succinate starch, 1.5 kg of sodium carboxymethyl cellulose and 90 kg of oligofructose evenly and put them into a premixing tank. Add 500 L of purified water, heat to 60 ℃, stir at 500 r / min until completely dissolved, cool to 25 ℃, then add 1.8 kg of citric acid and stir until all components are completely dissolved to form a homogeneous aqueous solution for later use. (ii) Add 6 kg of coenzyme Q10, 3 kg of caprylic acid glyceride and 3 kg of caprylic acid glyceride to another mixing tank. Place the material in the tank in a 55 ℃ constant temperature water bath and stir continuously at 300 r / min until the coenzyme Q10 is completely dissolved to obtain a homogeneous oil phase solution for later use. (III) Add 120 kg of glycerol, 1 kg of Tween 80 and 8 kg of polyglycerol fatty acid ester to the premix tank, add 200 L of purified water, control the stirring speed at 600 r / min, and continue stirring for 5 min to obtain a homogeneous emulsifier mixture for later use. (iv) Slowly add the oil phase solution to the aqueous phase solution while stirring at 1200 r / min. After the addition is complete, continue stirring for 5 min, then add the emulsifier mixture and continue stirring for 15 min to form a homogeneous pre-emulsion. Transfer the pre-emulsion to a high-pressure homogenizer and homogenize twice at 30 MPa for 10 min each time. Set aside. After homogenization, allow the emulsion to cool naturally to 25 ℃, add 1.8 kg of strawberry flavoring, and stir at 500 r / min for 5 min until the flavoring is evenly dispersed. Adjust the volume with the remaining purified water and continue stirring for 5 min to ensure the system is homogeneous. Fill the oral solution to 10 ml sterile glass bottles through a sterile filling line and seal them. Then place them in a water bath sterilizer and sterilize at 100 ℃ for 20 min. After sterilization, remove and allow to cool naturally to room temperature to obtain the Coenzyme Q10 oral solution.
[0023] Example 4 The difference between this embodiment and Example 1 is that the weight proportions of each component are as follows: 3 kg Coenzyme Q10, 12 kg sodium octenyl succinate starch, 2 kg Tween 80, 15 kg polyglycerol fatty acid ester, 1.5 kg sodium carboxymethyl cellulose, 100 kg glycerol, 75 kg fructooligosaccharides, 2.5 kg caprylic acid glyceride, 2.5 kg caprylic acid glyceride, 1.5 kg citric acid, 1.5 kg lemon flavoring, and the remainder is purified water; the rest of the operation is the same, and Coenzyme Q10 oral solution is prepared.
[0024] Example 5 The difference between this embodiment and Example 1 is that the weight proportions of each component are as follows: 5 kg Coenzyme Q10, 18 kg sodium octenyl succinate starch, 1 kg Tween 80, 8 kg polyglycerol fatty acid ester, 2 kg sodium carboxymethyl cellulose, 80 kg glycerol, 60 kg fructooligosaccharides, 2 kg caprylic acid glyceride, 2 kg caprylic acid glyceride, 1.2 kg citric acid, 1.2 kg lemon flavoring, and the remainder is purified water; the rest of the operation is the same, and Coenzyme Q10 oral solution is prepared.
[0025] Example 6 The difference between this embodiment and Example 1 is that the weight proportions of each component are as follows: 6 kg Coenzyme Q10, 20 kg sodium octenyl succinate starch, 3 kg Tween 80, 20 kg polyglycerol fatty acid ester, 3 kg sodium carboxymethyl cellulose, 120 kg glycerol, 90 kg fructooligosaccharides, 3 kg caprylic acid glyceride, 3 kg caprylic acid glyceride, 1.8 kg citric acid, 2.5 kg lemon flavoring, and the remainder is purified water; the rest of the operation is the same, and Coenzyme Q10 oral solution is prepared.
[0026] Example 7 The difference between this embodiment and Example 1 is that the weight proportions of each component are as follows: 2 kg Coenzyme Q10, 12 kg sodium octenyl succinate starch, 1 kg Tween 80, 5 kg polyglycerol fatty acid ester, 1.5 kg sodium carboxymethyl cellulose, 80 kg glycerol, 60 kg fructooligosaccharides, 2 kg caprylic acid glyceride, 2 kg caprylic acid glyceride, 0.8 kg citric acid, 1 kg lemon flavoring, and the remainder is purified water; the rest of the operation is the same, and Coenzyme Q10 oral solution is prepared.
[0027] Experimental Example 1 Stability evaluation experiment: To systematically verify the stability advantages of the oral liquid of this invention, Examples 1-3 and two mainstream commercially available coenzyme Q10 oral liquids were selected as test subjects. They were placed under accelerated stability test conditions of 37 ℃ and 75% RH for 3 months. Sensory characteristics (focusing on whether there was stratification and off-odors) and coenzyme Q10 retention were only tested at the initial stage and after 3 months. The specific testing methods and evaluation criteria are as follows: Sensory evaluation: Referring to the "General Specifications for Oral Liquid Preparations of Food", the core indicators are "whether it separates into layers" and "whether it has an off-odor". The evaluation is graded according to the following standards: Grade 1 - No separation, no off-odor; Grade 2 - Slight separation, no off-odor; Grade 3 - Obvious separation, no off-odor; Grade 4 - Severe separation, off-odor. Coenzyme Q10 retention rate: According to the "Catalogue of Raw Materials for Health Foods - Coenzyme Q10", the coenzyme Q10 content is tested, and the coenzyme Q10 retention rate is calculated according to the following formula. The results of the stability test are compared in Table 1.
[0028] W0: Initial coenzyme Q10 content measured before the accelerated stability test (0 months); W1: Actual residual coenzyme Q10 content determined after accelerated stability testing (3 months).
[0029] Table 1. Results of stability study
[0030] As can be seen from the data in Table 1, the Coenzyme Q10 oral solution prepared by the methods in Examples 1-3 showed significantly better stability than commercially available samples after 3 months of accelerated stability testing, and the Coenzyme Q10 retention rate was significantly higher than that of commercially available samples. This indicates that the Coenzyme Q10 oral solution prepared by this method has good stability, good Coenzyme Q10 solubility, and stable product properties.
[0031] This application provides a coenzyme Q10 oral liquid and its preparation method. Through component compounding and process optimization, the technical problems of poor water solubility and low stability of coenzyme Q10 are solved simultaneously. The product has both good taste and safety, and can be widely used in the health food field. Its preparation process uses conventional food production equipment, the operation steps are clear and controllable, it is easy to realize large-scale industrial production, and the production cost is lower than that of similar high-end products, which has significant economic value and market competitiveness.
[0032] The weight percentages of each component in this application refer to the relative proportion of the component's weight to the total weight of the oral liquid (the total system is set at 100 parts). Since purified water accounts for more than 80% of the oral liquid and has a density of approximately 1 g / mL, the total weight and volume of the oral liquid can be considered to be close. In actual production, the amount of each component can be calculated using the formula "target yield / 100 × number of components". In addition, depending on the production scale, the component proportions disclosed in this invention can be scaled up or down proportionally, and the technical effect is consistent with this embodiment.
[0033] The choice of edible flavoring in this invention is not limited to lemon, sweet orange, and strawberry flavoring. Other flavorings that meet food-grade standards (such as blueberry flavoring, peach flavoring, etc.) can be used as substitutes. The amount of purified water can be finely adjusted according to actual production needs, provided that all components are fully dissolved. Such substitutions and fine adjustments are within the scope of protection of this invention.
[0034] The above description is merely a preferred embodiment of this application and is not intended to limit this application. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of this application should be included within the protection scope of this application.
Claims
1. A coenzyme Q10 oral solution, characterized in that, By weight, it includes: 0.2-0.6 parts coenzyme Q10, 1.2-2 parts sodium octenyl succinate starch, 0.1-0.3 parts Tween 80, 0.5-2 parts polyglycerol fatty acid esters, 0.15-0.3 parts sodium carboxymethyl cellulose, 8-12 parts glycerol, 6-9 parts fructooligosaccharides, 0.2-0.3 parts caprylic acid glyceride, 0.2-0.3 parts decanoic acid glyceride, 0.08-0.18 parts citric acid, 0.1-0.25 parts food flavoring, and the balance being purified water.
2. The coenzyme Q10 oral solution according to claim 1, characterized in that, By weight, it includes: 0.3 parts coenzyme Q10, 1.2 parts sodium octenyl succinate starch, 0.2 parts Tween 80, 1.5 parts polyglycerol fatty acid esters, 0.15 parts sodium carboxymethyl cellulose, 10 parts glycerol, 7.5 parts fructooligosaccharides, 0.25 parts caprylic acid glyceride, 0.25 parts caprylic acid glyceride, 0.15 parts citric acid, 0.15 parts food flavoring, and the balance being purified water.
3. The coenzyme Q10 oral solution according to claim 1, characterized in that, By weight, it includes: 0.5 parts coenzyme Q10, 1.8 parts sodium octenyl succinate starch, 0.1 parts Tween 80, 0.8 parts polyglycerol fatty acid ester, 0.2 parts sodium carboxymethyl cellulose, 8 parts glycerol, 6 parts fructooligosaccharides, 0.2 parts caprylic acid glyceride, 0.2 parts caprylic acid glyceride, 0.12 parts citric acid, 0.12 parts food flavoring, and the balance being purified water.
4. A method for preparing a coenzyme Q10 oral solution, characterized in that, Specifically, the following steps are included: (a) Add sodium octenyl succinate starch, sodium carboxymethyl cellulose, fructooligosaccharides, and citric acid to a portion of purified water and mix to form an aqueous solution; (ii) Mix coenzyme Q10, caprylic acid glyceride, and caprylic acid glyceride, and heat and stir to dissolve to form an oil phase solution; (iii) Tween 80, polyglycerol fatty acid ester, and glycerol are added to a portion of purified water and stirred to prepare an emulsifier mixture; (iv) The aqueous solution and the oil solution are mixed, and the emulsifier mixture is added and stirred to form a primary emulsion; the primary emulsion is homogenized and cooled, and edible flavoring and purified water are added; after filling, sterilization and cooling, coenzyme Q10 oral solution is obtained.
5. The method for preparing a coenzyme Q10 oral solution according to claim 4, characterized in that, Step (1): Add purified water in an amount that is 40-50% of the total volume.
6. The method for preparing a coenzyme Q10 oral solution according to claim 4, characterized in that, In step (1), the mixing temperature of sodium octenyl succinate starch, sodium carboxymethyl cellulose, and fructooligosaccharides is 50-60 ℃, and the stirring speed is 300-500 r / min; the temperature is lowered to 20-25 ℃ before adding the citric acid.
7. The method for preparing a coenzyme Q10 oral solution according to claim 4, characterized in that, The heating temperature in step (ii) is 45-55 ℃, and the stirring speed is 200-300 r / min.
8. The method for preparing a coenzyme Q10 oral solution according to claim 4, characterized in that, The stirring speed in step (iii) is 400-600 r / min, and the stirring time is 5-10 min.
9. The method for preparing a coenzyme Q10 oral solution according to claim 4, characterized in that, Step (iv) The mixing speed of the aqueous solution and the oil solution is 800-1200 r / min; the homogenization pressure is 20-30 MPa, the homogenization is performed 2-3 times, and the homogenization time is 5-10 min.
10. The method for preparing a coenzyme Q10 oral solution according to claim 4, characterized in that, The sterilization temperature in step (iv) is 80-100 ℃ and the time is 20-30 min.