Amino acid shampoo without silicone oil and sulfate

Abstract

This invention discloses an amino acid shampoo that is free of silicone oil and sulfate, belonging to the field of daily chemical products technology. The amino acid shampoo of the present invention comprises the following components in parts by weight: 17.0-23.0 parts sodium α-olefin sulfonate, 1.0-3.0 parts lauryl glucoside, 4.0-7.0 parts cocamidopropyl betaine, 3.0-5.0 parts sodium lauroyl sarcosinate, 1.0-3.0 parts sodium cocoaminopropionate, 0.1-0.5 parts cocamide MEA, 1.2-4 parts hair conditioner, 1-4 parts plant extract, 0.1-0.3 parts anti-dandruff agent, 0.5-2.5 parts moisturizer, 0.4-0.6 parts thickener, 0.1-0.2 parts chelating agent, 0.1-0.2 parts pH adjuster, 1.5-3.1 parts fragrance, 1.3-2.2 parts colorant, 0.5-1.4 parts preservative, 0.1-0.4 parts stabilizer, and water to a total of 100 parts. The amino acid shampoo of this invention uses a combination of various surfactants to achieve synergistic effects while reducing irritation. It forms gentle micelles on the skin surface to effectively remove dirt and oil without excessive degreasing or damaging the lipid structure between skin keratinocytes, thereby maintaining the health and integrity of hair and scalp.

Description

Technical Field

[0001] This invention relates to the field of daily chemical products technology, and in particular to an amino acid shampoo that is free of silicone oil and sulfate. Background Technology

[0002] As people's living standards improve, functional cleansing shampoo and conditioner products are increasingly favored by consumers. Consumer demand for cleansing products is becoming more diversified, with people's requirements shifting towards green, safe, and healthy options. Consumers' needs for shampoos are no longer limited to basic cleansing power; shampoos that can deeply cleanse and care for the scalp and repair hair are gaining importance.

[0003] Traditional shampoos use silicone oil and cationic polymers as conditioning ingredients. During washing, some of the silicone oil is deposited on the hair to exert its effect, while the shampoo itself washes away some. However, this deposition-wash-off process doesn't always produce the same amount of silicone oil each time. Specifically, silicone oil accumulates on the hair with each use. This problem occurs regardless of the silicone oil deposition technology used in silicone-containing shampoos. With long-term use, the increased silicone oil buildup makes hair feel greasier, limp, and less voluminous, and it becomes increasingly prone to attracting dust. Furthermore, research has shown that long-term use of silicone-containing shampoos significantly increases the rate of hair follicle atrophy. Surfactants are the main ingredients in shampoos. The most commonly used surfactants include lauryl ether sulfate (AES) and lauryl sulfate (K12). These surfactants contain sulfates and have a strong degreasing ability similar to dish soap. While they can remove hair oil, they also damage the scalp's natural barrier, making the scalp dry. This dryness further stimulates the sebaceous glands to secrete more oil, creating a vicious cycle that leaves consumers with the dilemma of "no washing today, oily hair tomorrow." Summary of the Invention

[0004] The purpose of this invention is to overcome the shortcomings of the prior art and provide an amino acid shampoo that is free of silicone oil and sulfate.

[0005] To solve the above-mentioned technical problems, the technical solution adopted by the present invention is as follows: a silicone-free and sulfate-free amino acid shampoo, comprising the following components in parts by weight: 17.0-23.0 parts sodium α-olefin sulfonate, 1.0-3.0 parts lauryl glucoside, 4.0-7.0 parts cocamidopropyl betaine, 3.0-5.0 parts sodium lauroyl sarcosinate, 1.0-3.0 parts sodium cocoylaminopropionate, and 0.1-0.5 parts cocoyl... Amine MEA, 1.2-4 parts hair conditioner, 1-4 parts plant extract, 0.1-0.3 parts anti-dandruff agent, 0.5-2.5 parts moisturizer, 0.4-0.6 parts thickener, 0.1-0.2 parts chelating agent, 0.1-0.2 parts pH adjuster, 1.5-3.1 parts fragrance, 1.3-2.2 parts colorant, 0.5-1.4 parts preservative, 0.1-0.4 parts stabilizer, water to make up to 100 parts total.

[0006] The amino acid shampoo of this invention utilizes cocamidopropyl betaine and lauryl glucoside to insert into anionic surfactant micelles, forming mixed micelles with fewer charges and a looser structure, significantly reducing system irritation. Sodium α-alkenyl sulfonate provides the foam base, sodium lauroyl sarcosinate makes the foam fine and dense, and other components work together to stabilize the foam, achieving rapid foaming and long-lasting stability. By introducing sodium cocamidopropyl propionate and lauryl glucoside, rod-shaped micelles or lamellar liquid crystal structures are induced to form, achieving self-thickening of the system and reducing the dependence on sodium chloride. The dependence on sodium cocoaminopropionate is reduced by replacing the traditional sodium cocoamidoacetate, which highlights the thickening and conditioning functions. Sodium cocoaminopropionate is an anionic surfactant that combines mildness, thickening and conditioning properties. It can effectively increase the viscosity of the system and reduce the dependence on salt thickeners such as sodium chloride, making the formula simpler and milder. At the same time, it can form a moisturizing film on the hair, reduce the dryness after washing, and provide an immediate smoothness, achieving a "thoroughly clean but not dry" washing experience. After washing, the hair is smooth and easy to comb.

[0007] As a preferred embodiment of the amino acid shampoo of the present invention, it comprises the following components in parts by weight: 19.0-22.0 parts sodium α-alkenyl sulfonate, 1.0-2.0 parts lauryl glucoside, 5.0-6.0 parts cocamidopropyl betaine, 4.0-5.0 parts sodium lauroyl sarcosinate, 1.0-2.0 parts sodium cocoaminopropionate, 0.2-0.3 parts cocamide MEA, 1.4-2.6 parts hair conditioner, 2-3 parts plant extract, 0.1-0.4 parts anti-dandruff agent, 1.5-2.0 parts moisturizer, 0.2-1 part thickener, 0.1-0.3 parts chelating agent, 0.1-0.3 parts pH adjuster, 1.8-2.4 parts fragrance, 1.4-2.0 parts colorant, 0.6-1.0 parts preservative, 0.1-0.3 parts stabilizer, and water to a total of 100 parts.

[0008] As a preferred embodiment of the amino acid shampoo of the present invention, it comprises the following components in parts by weight: 20.0 parts sodium α-alkenyl sulfonate, 1.0 part lauryl glucoside, 6.0 parts cocamidopropyl betaine, 4.0 parts sodium lauroyl sarcosinate, 1.0 part sodium cocoamide propionate, 0.3 parts cocamide MEA, 2.1 parts hair conditioner, 3 parts plant extract, 0.2 parts anti-dandruff agent, 2.0 parts moisturizer, 0.6 parts thickener, 0.1 parts chelating agent, 0.1 parts pH adjuster, 2.2 parts fragrance, 1.67 parts colorant, 0.7 parts preservative, 0.2 parts stabilizer, and water to a total of 100 parts.

[0009] In a preferred embodiment of the amino acid shampoo of the present invention, the hair conditioning agent includes at least one of jojoba wax PEG-120 ester, polyquaternium-10, and polyquaternium-7.

[0010] The amino acid shampoo of the present invention, through the compounding of jojoba wax PEG-120 ester, polyquaternium-7, polyquaternium-10, and glycerin, solves the problem of "wet combing" while improving the touch and shine of "dry hair".

[0011] As a preferred embodiment of the amino acid shampoo of the present invention, the plant extract includes at least one of the following: Phellodendron bark extract, Coptis root extract, Sophora flavescens root extract, Rhus chinensis gall extract, Cnidium monnieri extract, Zanthoxylum bungeanum fruit extract, and Cinnamomum camphora root / stem extract.

[0012] Through extensive experimental research, the inventors of this application discovered that amino acid shampoos prepared from extracts of Phellodendron bark, Coptis root, Sophora flavescens root, Rhus chinensis gall, Cnidium monnieri, Zanthoxylum bungeanum fruit, and Cinnamomum camphora root / stem extract obtained by different extraction methods have essentially the same efficacy. This indicates that in the amino acid shampoo of this invention, the specific extraction method of the plant extracts has no effect on the efficacy of the amino acid shampoo.

[0013] In a preferred embodiment of the amino acid shampoo of the present invention, the dandruff-removing agent is pyrrolidone ethanolamine salt.

[0014] As a preferred embodiment of the amino acid shampoo of the present invention, it includes at least one of the following (a)-(f): (a) The thickener comprises at least one of PEG-120 methyl glucoside ester and acrylate / C10-30 alkanol acrylate crosspolymer; (b) The chelating agent includes disodium EDTA; (c) The pH adjuster includes citric acid; (d) The preservative includes at least one of methylparaben and phenoxyethanol; (e) The stabilizer is sodium chloride; (f) The moisturizer is glycerin.

[0015] This invention also provides a method for preparing the aforementioned amino acid shampoo, comprising the following steps: S1. Take sodium α-alkenyl sulfonate, lauryl glucoside, cocamidopropyl betaine, sodium lauroyl sarcosinate, sodium cocoamide propionate, cocamide MEA, some hair conditioning agents, moisturizers, chelating agents, some thickeners, some preservatives and water, stir and heat until completely dissolved to obtain phase A; S2. Take a portion of hair conditioner, a portion of thickener and water, mix them together, add phase A, keep warm and stir to obtain phase B; S3. Stir and cool phase B to below 50°C, add the anti-dandruff agent, stir, and obtain phase C; S4. Take a portion of hair conditioner, a portion of preservative and pH adjuster, add them to phase C which has been cooled to below 45°C, stir well to obtain phase D; S5. Add the stabilizer, fragrance and colorant to phase D in sequence and stir until completely dispersed to obtain amino acid shampoo.

[0016] This invention uses a gradient temperature control process to prepare amino acid shampoo, which can improve the retention rate of active ingredients, enhance the efficacy of the shampoo, and improve its stability.

[0017] In a preferred embodiment of the preparation method of the amino acid shampoo of the present invention, the stirring speed in step S1 is 50 rpm; the heating in step S1 is to heat to 85°C.

[0018] In a preferred embodiment of the preparation method of the amino acid shampoo of the present invention, the stirring speed in step S2 is 30 rpm.

[0019] Compared with existing technologies, the beneficial effects of this invention are as follows: This invention provides an amino acid shampoo, which constructs an amino acid shampoo with a multi-layered synergistic system of "primary cleansing - auxiliary gentleness - functional modification". Sodium α-alkenyl sulfonate (AOS) serves as the framework, providing excellent cleansing power and rich foam. Sodium lauroyl sarcosinate greatly improves the fineness and stability of the foam and enhances the gentleness of the system. Cocamidopropyl betaine effectively reduces overall irritation by forming mixed micelles with AOS. Lauryl glucoside (APG) acts as a compatibility bridge, synergistically enhancing gentleness and system viscosity. The amino acid shampoo of this invention uses a preferred combination of sodium α-alkenyl sulfonate, sodium lauroyl sarcosinate, sodium cocoylaminopropionate, lauryl glucoside, and cocamide MEA. While synergistically enhancing the effects, it can reduce irritation, forming gentle micelles on the skin surface to effectively remove dirt and oil without excessive degreasing or damaging the lipid structure between skin keratinocytes, thereby maintaining the health and integrity of hair and scalp. Meanwhile, the amino acid shampoo of the present invention has good stability, and long-term storage at high temperatures has little impact on the active ingredients in the shampoo. Attached Figure Description

[0020] Figure 1 The image shows the chorioallantoic membrane of a chicken embryo, which is the negative control in Example 4.

[0021] Figure 2 The image shows the chorioallantoic membrane of a chicken embryo, which is the positive control in Example 4.

[0022] Figure 3 The diagram shows the chicken embryo chorioallantoic membrane test in Example 1 of Example 4.

[0023] Figure 4 The diagram shows the chicken embryo chorioallantoic membrane test in Example 2 of Effect Example 4.

[0024] Figure 5 The diagram shows the chicken embryo chorioallantoic membrane test in Example 3 of Example 4.

[0025] Figure 6 The diagram shows the chicken embryo chorioallantoic membrane test in Example 4 of Effect Example 4.

[0026] Figure 7 The diagram shows the chicken embryo chorioallantoic membrane test in Example 5 of Effect Example 4.

[0027] Figure 8 The diagram shows the chicken embryo chorioallantoic membrane test in Example 6 of Example 4.

[0028] Figure 9 The diagram shows the chicken embryo chorioallantoic membrane test in Example 7 of Effect Example 4.

[0029] Figure 10The diagram shows the chicken embryo chorioallantoic membrane test in Example 8 of Example 4.

[0030] Figure 11 The diagram shows the chicken embryo chorioallantoic membrane test in Example 9 of Effect Example 4.

[0031] Figure 12 This is a diagram of the chicken embryo chorioallantoic membrane test in Example 10 of Effect Example 4.

[0032] Figure 13 The diagram shows the chicken embryo chorioallantoic membrane test in Example 11 of Effect Example 4.

[0033] Figure 14 This is a diagram of the chicken embryo chorioallantoic membrane test in Example 12 of Effect Example 4.

[0034] Figure 15 This is a diagram of the chicken embryo chorioallantoic membrane test in Example 13 of Effect Example 4.

[0035] Figure 16 This is a diagram of the chicken embryo chorioallantoic membrane test in Comparative Example 1 of Effect Example 4.

[0036] Figure 17 This is a diagram of the chicken embryo chorioallantoic membrane test in Comparative Example 2 of Effect Example 4.

[0037] Figure 18 This is a diagram of the chicken embryo chorioallantoic membrane test in Comparative Example 3 of Effect Example 4.

[0038] Figure 19 This is a diagram of the chicken embryo chorioallantoic membrane test in Comparative Example 4 of Effect Example 4.

[0039] Figure 20 This is a diagram of the chicken embryo chorioallantoic membrane test in Comparative Example 5 of Effect Example 4.

[0040] Figure 21 This is a diagram of the chicken embryo chorioallantoic membrane test in Comparative Example 6 of Effect Example 4.

[0041] Figure 22 This is a diagram of the chicken embryo chorioallantoic membrane test in Comparative Example 7 of Effect Example 4. Detailed Implementation

[0042] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0043] In the embodiments and comparative examples of this invention: Sodium α-alkenylsulfonate: AOS, Linyi Lusen Chemical Co., Ltd.; Lauryl glucoside: GreenAPG 1214, Shanghai Fakai Chemical Co., Ltd.; Cocamidopropyl betaine: KY-CAB-35S, Guangdong Keyu New Materials Co., Ltd.; Sodium lauroyl sarcosinate: AS02-30, Changsha Puji Biotechnology Co., Ltd.; Sodium cocoylaminopropionate: YB02-30, Changsha Puji Biotechnology Co., Ltd.; Glycerin: MOON K GLYCERIN, PROCTER&GAMBLE INTERNATIONAL OPERATIONS SASINGAPORE BRANCH P&G Chemicals; Jojoba wax PEG-120 ester: Water-soluble jojoba ester, Guangzhou Xinlongda Industrial Co., Ltd.; Disodium EDTA: Dissolvine NA2 (Disodium ethylenediaminetetraacetate), Nouryon Chemicals (Ningbo) Co., Ltd.; PEG-120 Methyl Glucose Dioleate: GLUCO DOE120, Guangzhou Tinci Advanced Materials Co., Ltd.; Cocamide MEA: KY-CMEA-100, Guangdong Keyu New Materials Co., Ltd.; Methylparaben: Methylparaben, Zhejiang Shengxiao Chemical Co., Ltd.; Acrylic (ester) / C10-30 alkanol acrylate crosspolymer: CARBOPOL® Ultrez 20 Polymer, Lubrizol Advanced Materials, Inc.; Polyquaternium-10: JR-125, Dow Chemical (Shanghai) Co., Ltd.; Piroctone Olamine (X74468B), APP Fragrances & Flavors Inc. Phenoxyethanol: Phenoxyethanol, Guangdong Dimei Biotechnology Co., Ltd.; Polyquaternium-7: M-550, Zhaoqing Huada Detergent Raw Material Factory; Citric acid: Citric acid monohydrate, Weifang Yingxuan Industrial Co., Ltd.; Plant extract: Xiaoshuning I, Guangzhou Fuyulong Biotechnology Co., Ltd.; Sodium chloride (NaCl), Jiangxi Jiuer Salt Industry Co., Ltd. Fragrances: QD-15498, Guangzhou Quande Fragrance & Flavor Co., Ltd.; AYX1053 / 8, Guangzhou Shengzhi Fragrance & Flavor Co., Ltd.; HY92008, Guangzhou Zhongying Fragrance & Flavor Co., Ltd.; HY92010, Guangzhou Zhongying Fragrance & Flavor Co., Ltd.; HY92009, Guangzhou Zhongying Fragrance & Flavor Co., Ltd.

[0044] Coloring agents: DS-101, Shandong Aipu Food Industry Co., Ltd.; PONCEAU 4R 80% E124-C, Senxin Flavor & Pigment Technology (China) Co., Ltd.

[0045] Example 1 This invention provides an amino acid shampoo comprising the following components in parts by weight: 20.0 parts sodium α-alkenyl sulfonate, 6.0 parts cocamidopropyl betaine, 1.0 part lauryl glucoside, 4.0 parts sodium lauroyl sarcosinate, 1.0 part sodium cocoamide propionate, 0.3 parts cocamide MEA, 0.3 parts polyquaternium-10, 0.3 parts polyquaternium-7, 3.0 parts plant extracts, and 1.5 parts jojoba wax PEG- The composition includes: 120 esters, 0.2 parts piroctone ketone ethanolamine salt, 2.0 parts glycerol, 0.3 parts PEG-120 methyl glucoside dioleate, 0.3 parts acrylate / C10-30 alkanol acrylate crosspolymer, 0.1 parts disodium EDTA, 0.1 parts citric acid, 2.2 parts fragrance, 1.68 parts colorant, 0.2 parts methylparaben, 0.5 parts phenoxyethanol, 0.2 parts sodium chloride, and water to a total of 100 parts. The fragrance includes 0.5 parts QD-15498, 0.2 parts AYX1053 / 8, 0.3 parts HY92008, 0.3 parts HY92010, and 0.9 parts HY92009; the colorant includes 1.25 parts DS-101 and 0.43 parts PONCEAU 4R 80% E124-C.

[0046] The specific preparation method of the amino acid shampoo in this embodiment is as follows: S1. Take sodium α-alkenyl sulfonate, lauryl glucoside, cocamidopropyl betaine, sodium lauroyl sarcosinate, sodium cocoamide propionate, cocamidopropylamine MEA, jojoba wax PEG-120 ester, glycerol, disodium EDTA, PEG-120 methyl glucodioleate, methylparaben, and water, and heat to 85°C with stirring at 50 rpm until completely dissolved to obtain phase A; S2. Take acrylic (ester) / C10-30 alkanol acrylate crosspolymer, polyquaternium-10 and water, mix them and add phase A, stir evenly at 50 rpm to obtain phase B, keep at 85℃ and stir at 30 rpm for 20 minutes; S3. Stir and cool phase B to below 50°C, add pyrrolidone ethanolamine salt, and stir at 30 rpm for 20 minutes to obtain phase C; S4. Take phenoxyethanol, polyquaternium-7, plant extract and citric acid, add them to phase C which has been cooled to below 45°C, stir evenly to obtain phase D; S5. Add sodium chloride, fragrance and colorant to phase D in sequence and stir until completely dispersed to obtain amino acid shampoo.

[0047] Example 2-13 Examples 2-13 provide an amino acid shampoo, the composition of which is shown in Table 1.

[0048] Table 1 Comparative Examples 1-7 Comparative Examples 1-7 provide an amino acid shampoo, the composition of which is shown in Table 2.

[0049] Table 2 Example of effect 1. Safety evaluation The amino acid shampoos prepared in Examples 1-14 were evaluated for cosmetic irritation.

[0050] The study population consisted of 140 female participants (10 participants per group, 14 groups in total), aged 16-65 years. Participants had healthy skin, no history of skin diseases or allergies, and met the voluntary inclusion criteria.

[0051] The test method was a human patch test. A qualified patch applicator was selected, and approximately 0.020-0.025g of the test substance was placed inside. The patch applicator containing the test substance was then applied to the back or flexor side of the forearm of the subject using non-irritating adhesive tape. Gently press the patch applicator with the palm of the hand to ensure even adhesion to the skin, and leave it on for 24 hours. Thirty minutes after removing the patch applicator, the skin reaction was observed after the pressure marks disappeared. If the result was negative, repeat observations were performed at 24 hours and 48 hours after the patch test. The results were recorded according to the 2015 "Cosmetic Safety Technical Specifications".

[0052] Evaluation criteria: Grade 0: Negative reaction; Grade 1: Suspicious reaction, only slight erythema; Grade 2: Weak positive reaction, erythema, infiltration, edema, and possible papules; Grade 3: Strong positive reaction, erythema, infiltration, edema, and possible papules, reaction may extend beyond the test area; Grade 4: Very strong positive reaction, obvious erythema, severe infiltration, edema, confluent herpes, reaction extends beyond the test area.

[0053] The results of the human skin patch test showed that the skin reactions of the subjects were observed at 24h and 48h after the patch test of the amino acid shampoo prepared in Examples 1-14. All subjects had negative skin reactions, indicating that the amino acid shampoo prepared in Examples 1-14 is safe to use.

[0054] 2.2. Anti-dandruff and anti-itch effects This effect example verifies the dandruff-reducing and antipruritic effects of the amino acid shampoos of Examples 1-13 and Comparative Examples 1-7. The specific experimental methods are as follows: The shampoo's dandruff-reducing and anti-itch effects were verified by measuring its bactericidal rate against Malassezia furfur, Escherichia coli, and Staphylococcus aureus in vitro.

[0055] (1) Determination of the bactericidal rate of shampoo against Malassezia furfur: Prepare physiological saline containing 0.1% Tween 80 and 1×10 6 ~1×10 7 Prepare a bacterial suspension of CFU / mL. Take 10mL of shampoo concentrate and dilute it 10-fold with physiological saline containing 0.1% Tween 80 to prepare the test sample solution. Add 0.1mL of bacterial suspension and 0.9mL of test sample solution to a test tube, mix, and immediately start timing. Gently shake in a 20-25℃ water bath for 5 minutes. Immediately after 5 minutes, add 9mL of physiological saline containing 0.1% Tween 80 to stop the reaction. Pour 1mL of the final mixture into a sterile Petri dish, add 15mL of culture medium cooled to 45℃, mix well, allow to solidify, and incubate upside down at 37℃ for 2-3 days. Set up a positive control group (0.1mL bacterial suspension and 0.9mL physiological saline containing 0.1% Tween 80) and a negative control group (0.1mL physiological saline containing 0.1% Tween 80 and 0.9mL test sample solution), and repeat each experiment three times. After incubation, count the number of colonies on each plate and calculate the sterilization rate according to the formula.

[0056] Sterilization rate = ×100%.

[0057] (2) Determination of the bactericidal rate of the shampoo against Escherichia coli and Staphylococcus aureus: Replace the physiological saline containing 0.1% Tween 80 with physiological saline containing 3% Tween 80 and 0.3% lecithin. Perform the remaining steps as described above, and finally incubate at 37°C upside down for 24-36 hours. Set up a positive control group (0.1 mL bacterial suspension and 0.9 mL physiological saline containing 3% Tween 80 and 0.3% lecithin) and a negative control group (physiological saline containing 3% Tween 80 and 0.3% lecithin and 0.9 mL of the test sample solution). Each group was tested three times. After the incubation, count the number of colonies on the plates in each group and calculate the bactericidal rate according to the formula.

[0058] Sterilization rate = ×100%.

[0059] The results are shown in Table 3.

[0060] Table 3 3. Hair combing effect test This example tests the combing effect on hair after using the amino acid shampoos of Examples 1-13 and Comparative Examples 1-7. The specific experimental methods are as follows: (1) Dry hair combing ability test: 105 hair bundles bleached once were prepared and randomly divided into 21 groups of 5 hair bundles each. Before the test, the hair bundles were cleaned and dried at room temperature. 2 mL of the test sample was gently and evenly applied to the hair bundles, rinsed with tap water, and dried at room temperature before testing. The control group was not applied with the sample, the hair bundles were rinsed with tap water, and dried before testing. Before and after the use of the sample, the hair bundles were fixed with test clips and the combing ability test was performed. The test was repeated 5 times, and the relevant data were recorded and the change rate of combing ability of the hair bundles before and after using the test sample was calculated. The average value of the test results was taken. Change rate of dry hair combing ability (%) = (combing ability of the hair bundle after using the test sample - combing ability of the hair bundle before using the test sample) / combing ability of the hair bundle before using the test sample × 100%.

[0061] (2) Wet combing performance test: 105 hair bundles bleached once were prepared and randomly divided into 21 groups of 5 hair bundles each. Before the test, the hair bundles were cleaned and dried at room temperature. The hair bundles were soaked in water and then placed on the test clip for wet combing performance test. The test was repeated 5 times, and the wet combing performance before use was recorded. 2 mL of the test sample was gently and evenly applied to the hair bundle, rinsed with tap water, and dried at room temperature before testing. The control group was not coated with the sample, the hair bundles were rinsed with tap water, and dried before testing. After use, the samples were rinsed with water and then placed on the test clip for wet combing performance test. The test was repeated 5 times, and the wet combing performance after use was recorded. For each group, relevant data were recorded and the change rate of combing performance before and after using the test sample was calculated. The test results were averaged. Change rate of wet combing performance of hair bundle (%) = (combing performance of hair bundle after using the test sample - combing performance of hair bundle before using the test sample) / combing performance of hair bundle before using the test sample × 100%. Note: Negative numbers indicate a reduction in combing work.

[0062] The results are shown in Table 4.

[0063] Table 4 3.3 Foam Height Test This example uses a Roche foam analyzer to measure the foam height of the amino acid shampoos of Examples 1-13 and Comparative Examples 1-7. The experimental method is as follows: Using the amino acid shampoos of Examples 1-13 and Comparative Examples 1-7 as test samples, the thermostat was preheated to 40℃, and the Roche foam analyzer was kept at a constant temperature of 40℃. 2.0g of shampoo was weighed, 100mL of hard water was added, and then 900mL of distilled water was added. The mixture was heated to 40℃ and stirred until the sample was uniformly dissolved. First, the Roche foam analyzer was rinsed with distilled water. A portion of the test solution was drawn into a 200mL quantitative funnel and rinsed along the foam tube wall. Then, 50mL of the test solution was placed at the bottom of the foam analyzer, and the test solution was drawn into a 200mL quantitative funnel. The center of the funnel was fixed, and the test solution was lowered. The foam height was recorded at 0s, 30s, and 3min. Each sample was tested 3 times, and the average value of the 3 results was calculated to obtain the foam height of the sample.

[0064] The results are shown in Table 5.

[0065] Table 5 4. Stability Test This example examines the stability of the amino acid shampoos of Examples 1-13 and Comparative Examples 1-7, including room temperature stability and high temperature stability. The stability of the amino acid shampoos is determined by observing whether changes occur when placed under different conditions. If no changes occur, the test is passed. If the amino acid shampoo does not separate into layers or change color after centrifugation, the test is passed. Specifically: Heat resistance test: Pour the sample into two test tubes with a diameter of ϕ20mm×120mm, making the liquid level approximately 80mm, and plug them with clean stoppers. Place one of the test tubes in a constant temperature incubator pre-adjusted to 40℃, remove it after 24 hours, allow it to return to room temperature, and then visually compare it with the sample in the other test tube.

[0066] Cold resistance test: Pour the sample into two test tubes with a diameter of ϕ20mm×120mm, making the liquid level about 80mm, and stopper them with clean stoppers. Place one of the test tubes to be tested in a refrigerator pre-adjusted to -8℃, remove it after 24 hours, allow it to return to room temperature, and then visually compare it with the sample in the other test tube.

[0067] Cyclic Test: Pour the sample into two test tubes (ϕ20mm×120mm) to a liquid level of approximately 80mm, and plug them with clean stoppers. After placing the sample at room temperature for 24 hours, place it in a pre-set high and low temperature alternating test chamber. One cycle test procedure is: 24 hours at low temperature (-10℃) → 2 hours at room temperature (25℃) → 24 hours at high temperature (45℃) → 2 hours at room temperature (25℃). Repeat this cycle 5 times. After returning to room temperature, visually compare the sample with the sample in another test tube. Set up 3-5 parallel experiments.

[0068] Centrifugation test: Fill centrifuge tubes with the sample to about 2 / 3 of their height and seal them tightly with a stopper. Then place them in an electric thermostatic incubator pre-adjusted to 38℃ and maintain for 1 hour. Immediately afterward, transfer them to a centrifuge and adjust the centrifuge speed to 2000 rpm. Centrifuge for 30 minutes and then remove them for observation.

[0069] The results are shown in Table 6.

[0070] Table 6 As shown in Table 6, the amino acid shampoo prepared by this invention has stability at both room temperature and high temperature.

[0071] 4.4. Mild and safe This invention selects the chicken embryo chorioallantoic membrane test, which has high sensitivity and can replace animal testing, to evaluate the irritation of shampoo.

[0072] White-coated anti-SPF chicken embryos were selected and incubated at 38.0℃ until 8 days of age. Egg candling was used to examine embryo development and blood vessel growth. Well-developed embryos were selected and their air cells were marked for experimental use.

[0073] Use dental serrated curved forceps to peel away the marked portion of the eggshell, exposing the white egg membrane. Add 0.3 mL of 0.9% sodium chloride solution using a pipette to moisten the egg membrane for 1 minute. Carefully remove the inner membrane with forceps. The sample in this invention is a transparent liquid sample, and its irritation is assessed using the reaction time method. A negative control group (0.9% sodium chloride solution) and a positive control group (0.1 mol / L sodium hydroxide solution) were set up.

[0074] Reaction time method: 0.3 ml of sample / control was directly added to the surface of the chorioallantoic membrane, and the time of occurrence of each toxic effect was observed and recorded within 5 min. The IS method was used as the scoring standard.

[0075] Stimulus assessment is performed using the reaction time method, and the following formula is applied for calculation. IS= + in, sec H Indicates the time of bleeding. sec L Indicates the time to vascular dissolution. sec C Indicates clotting time.

[0076] IS<1 indicates no irritation, 1≤IS<5 indicates mild irritation, 5≤IS<9 indicates moderate irritation, and IS≥9 indicates strong irritation.

[0077] Results Table 7 Figure 1-22 As shown.

[0078] Table 7 As shown in Table 7, sodium α-alkenyl sulfonate has good foaming effect but is somewhat irritating. Cocamidopropyl betaine can effectively reduce the irritation caused by sodium α-alkenyl sulfonate. For example, Comparative Example 4 did not add cocamidopropyl betaine, resulting in irritation in the shampoo. The amino acid shampoo of the present invention uses a preferred compound of sodium α-alkenyl sulfonate, sodium lauroyl sarcosinate, sodium cocoamide propionate, lauryl glucoside, and cocamide MEA. While achieving synergistic effects, it can reduce irritation and form gentle micelles on the skin surface, effectively removing dirt and oil without excessive degreasing or damaging the lipid structure between skin keratinocytes, thereby maintaining the health and integrity of hair and scalp.

[0079] Finally, it should be noted that the specific embodiments described above have further illustrated the purpose, technical solution, and beneficial effects of the present invention. It should be understood that the above descriptions are merely specific embodiments of the present invention and are not intended to limit the scope of protection of the present invention. In particular, it should be pointed out that any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention for those skilled in the art.

Claims

1. A silicone-free and sulfate-free amino acid shampoo, characterized in that, The product comprises the following components in parts by weight: 17.0-23.0 parts sodium α-alkenyl sulfonate, 1.0-3.0 parts lauryl glucoside, 4.0-7.0 parts cocamidopropyl betaine, 3.0-5.0 parts sodium lauroyl sarcosinate, 1.0-3.0 parts sodium cocoaminopropionate, 0.1-0.5 parts cocamide MEA, 1.2-4 parts hair conditioner, 1-4 parts plant extracts, 0.1-0.3 parts anti-dandruff agent, 0.5-2.5 parts moisturizer, 0.4-0.6 parts thickener, 0.1-0.2 parts chelating agent, 0.1-0.2 parts pH adjuster, 1.5-3.1 parts fragrance, 1.3-2.2 parts colorant, 0.5-1.4 parts preservative, 0.1-0.4 parts stabilizer, and water to a total of 100 parts.

2. The amino acid shampoo according to claim 1, characterized in that, The product comprises the following components in parts by weight: 19.0-22.0 parts sodium α-alkenyl sulfonate, 1.0-2.0 parts lauryl glucoside, 5.0-6.0 parts cocamidopropyl betaine, 4.0-5.0 parts sodium lauroyl sarcosinate, 1.0-2.0 parts sodium cocoaminopropionate, 0.2-0.3 parts cocamide MEA, 1.4-2.6 parts hair conditioner, 2-3 parts plant extracts, 0.1-0.4 parts anti-dandruff agent, 1.5-2.0 parts moisturizer, 0.2-1 part thickener, 0.1-0.3 parts chelating agent, 0.1-0.3 parts pH adjuster, 1.8-2.4 parts fragrance, 1.4-2.0 parts colorant, 0.6-1.0 parts preservative, 0.1-0.3 parts stabilizer, and water to a total of 100 parts.

3. The amino acid shampoo according to claim 2, characterized in that, The product comprises the following components in parts by weight: 20.0 parts sodium α-alkenyl sulfonate, 1.0 part lauryl glucoside, 6.0 parts cocamidopropyl betaine, 4.0 parts sodium lauroyl sarcosinate, 1.0 part sodium cocoaminopropionate, 0.3 parts cocamide MEA, 2.1 parts hair conditioner, 3 parts plant extracts, 0.2 parts anti-dandruff agent, 2.0 parts moisturizer, 0.6 parts thickener, 0.1 parts chelating agent, 0.1 parts pH adjuster, 2.2 parts fragrance, 1.67 parts colorant, 0.7 parts preservative, 0.2 parts stabilizer, and water to a total of 100 parts.

4. The amino acid shampoo according to any one of claims 1-3, characterized in that, The hair conditioning agent includes at least one of jojoba wax PEG-120 ester, polyquaternium-10, and polyquaternium-7.

5. The amino acid shampoo according to any one of claims 1-3, characterized in that, The plant extracts include at least one of the following: Phellodendron bark extract, Coptis root extract, Sophora flavescens root extract, Rhus chinensis gall extract, Cnidium monnieri extract, Zanthoxylum bungeanum fruit extract, and Cinnamomum camphora root / stem extract.

6. The amino acid shampoo according to any one of claims 1-3, characterized in that, The anti-dandruff agent is piroctone ethanolamine salt.

7. The amino acid shampoo according to any one of claims 1-3, characterized in that, Includes at least one of the following (a)-(f): (a) The thickener comprises at least one of PEG-120 methyl glucoside ester and acrylate / C10-30 alkanol acrylate crosspolymer; (b) The chelating agent includes disodium EDTA; (c) The pH adjuster includes citric acid; (d) The preservative includes at least one of methylparaben and phenoxyethanol; (e) The stabilizer is sodium chloride; (f) The moisturizer is glycerin.

8. The method for preparing the amino acid shampoo according to any one of claims 1-7, characterized in that, Includes the following steps: S1. Take sodium α-alkenyl sulfonate, lauryl glucoside, cocamidopropyl betaine, sodium lauroyl sarcosinate, sodium cocoamide propionate, cocamide MEA, some hair conditioning agents, moisturizers, chelating agents, some thickeners, some preservatives and water, stir and heat until completely dissolved to obtain phase A; S2. Take a portion of hair conditioner, a portion of thickener and water, mix them together, add phase A, keep warm and stir to obtain phase B; S3. Stir and cool phase B to below 50°C, add the anti-dandruff agent, stir, and obtain phase C; S4. Take a portion of hair conditioner, a portion of preservative and pH adjuster, add them to phase C which has been cooled to below 45°C, stir well to obtain phase D; S5. Add the stabilizer, fragrance and colorant to phase D in sequence and stir until completely dispersed to obtain amino acid shampoo.

9. The preparation method according to claim 8, characterized in that, The stirring speed in step S1 is 50 rpm; the heating in step S1 is to heat to 85°C.

10. The preparation method according to claim 8, characterized in that, The stirring speed in step S2 is 30 rpm.

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