A shenqi rongzhu ointment and a preparation method thereof

Abstract

The application discloses a ginseng and astragalus royal technique ointment, which is prepared from main materials and auxiliary materials; the main materials comprise the following raw materials in parts by weight: raw astragalus 30-80; angelica 10-20; ginseng 4-10; prepared rehmannia 15-20; white peony root 8-12; rhodiola 3-5; poria cocos 10-30; fried atractylodes 8-15; amomum villosum 3-15; dried tangerine or orange peel 10-15; cyperus rotundus 5-15; costus 5-20; bletilla 5-15; caulis Bambusae 10-30; fried liquorice 4-6; the auxiliary materials are honey and granulated sugar; meanwhile, the application also discloses a preparation method of the ginseng and astragalus royal technique ointment. The ginseng and astragalus royal technique ointment has the effects of benefiting qi and nourishing blood, invigorating the spleen and stomach, soothing the liver and relieving depression, and stopping bleeding and astringing sores, can be used for improving symptoms such as poor appetite, poor spirit and anemia after malignant tumor operation, and promoting wound healing. The ointment has good taste, is convenient to take, has mild efficacy, and is suitable for long-term taking during a postoperative recovery period.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine preparation technology, specifically relating to a ginseng and astragalus ointment and its preparation method for improving loss of appetite, fatigue, and anemia in patients with malignant tumors after major surgery, as well as reducing postoperative drainage and promoting wound healing. Background Technology

[0002] Patients undergoing spinal, joint, or complex trauma surgeries, especially those with malignant tumors who have undergone major surgeries (such as bone tumor resection, radical gastrectomy, radical colorectal cancer resection, lung cancer resection, etc.), often experience severe systemic debility due to surgical trauma, blood loss, anesthesia, and postoperative stress. Common clinical symptoms include: poor appetite, loss of taste, fatigue, shortness of breath, lethargy, pale complexion, dizziness, palpitations, and pale lips and nails. Laboratory tests may reveal decreased hemoglobin and red blood cell counts (i.e., postoperative anemia). Furthermore, significant postoperative wound bleeding and exudation often necessitate drainage tubes; excessive drainage not only delays recovery but also increases the risk of infection.

[0003] Traditional Chinese medicine (TCM) considers surgery to be a form of "brutal injury," directly depleting qi and blood. Combined with the fact that tumors themselves are often "depleted by prolonged illness," postoperative symptoms typically include qi and blood deficiency, and spleen and stomach weakness. The spleen and stomach are the foundation of acquired constitution and the source of qi and blood production. Postoperative dysfunction of the spleen and stomach leads to poor appetite and insufficient qi and blood; qi and blood deficiency results in fatigue and anemia. Simultaneously, qi fails to contain blood, and blood does not circulate properly, leading to persistent bleeding from the wound; increased drainage further delays wound healing. Furthermore, postoperative patients often experience emotional depression and liver qi stagnation, with the liver overacting on the spleen, further exacerbating spleen and stomach dysfunction. Therefore, postoperative treatment for malignant tumors should focus on tonifying qi and blood, strengthening the spleen and stomach, and soothing the liver and relieving depression, while also addressing hemostasis, wound healing, and promoting healing.

[0004] Most commercially available traditional Chinese medicine (TCM) products target single symptoms such as cancer-related fatigue or tumor-associated anemia, lacking comprehensive formulations specifically designed for the postoperative period that simultaneously improve poor appetite, low energy, anemia, reduce drainage, and promote wound healing. Furthermore, existing products are mostly in granule or capsule form, which have unpleasant tastes and are inconvenient for postoperative patients with swallowing difficulties. TCM ointments (medicinal pastes) have advantages such as mild efficacy, good taste, convenient administration, and portability, making them particularly suitable for long-term conditioning during postoperative recovery. Therefore, developing a TCM preparation that can invigorate qi and blood, strengthen the spleen and stomach, soothe the liver and relieve depression, stop bleeding, promote wound healing, and is in ointment form has significant clinical value. Summary of the Invention

[0005] In view of this, the purpose of the present invention is to provide a ginseng, astragalus and atractylodes ointment and its preparation method, which is used to improve symptoms such as poor appetite, poor mental state and anemia after surgery for malignant tumors, and to promote wound healing.

[0006] To achieve the above objectives, the present invention provides the following technical solution:

[0007] A ginseng, astragalus, and atractylodes ointment, made from main ingredients and pharmaceutically acceptable excipients; the main ingredients include the following raw materials in parts by weight: raw astragalus 30-80; angelica 10-20; ginseng 4-10; prepared rehmannia 15-20; white peony 8-12; rhodiola 3-5; poria 10-30; stir-fried atractylodes 8-15; amomum 3-15; tangerine peel 10-15; cyperus 5-15; costus root 5-20; bletilla striata 5-20; chicken blood vine 10-30; prepared licorice root 4-6.

[0008] Preferably, the auxiliary materials are honey and rock sugar.

[0009] Preferably, the main ingredients include the following raw medicinal materials in parts by weight: Astragalus membranaceus 60; Angelica sinensis 15; Ginseng 7; Rehmannia glutinosa 18; Paeonia lactiflora 10; Rhodiola rosea 4; Poria cocos 20; Atractylodes macrocephala 12; Amomum villosum 10; Citrus reticulata 12; Cyperus rotundus 10; Aucklandia lappa 10; Bletilla striata 10; Spatholobus suberectus 20; Glycyrrhiza uralensis 5.

[0010] Preferably, the auxiliary material is composed of the following raw materials in parts by weight: honey 400-600; rock sugar 200-300.

[0011] This invention also provides a method for preparing a ginseng, astragalus, and atractylodes extract, which uses the aforementioned ginseng, astragalus, and atractylodes extract, and the preparation method includes the following steps:

[0012] (1) Soak raw Astragalus membranaceus, Angelica sinensis, ginseng, Rehmannia glutinosa, Paeonia lactiflora, Rhodiola rosea, Poria cocos, stir-fried Atractylodes macrocephala, Cyperus rotundus, Aucklandia lappa, Bletilla striata, Spatholobus suberectus, and prepared Glycyrrhiza uralensis in water and decoct them 2-3 times. Add Amomum villosum and Citrus reticulata 5-10 minutes before the end of the first decoction.

[0013] (2) Combine the decoctions, filter, let stand, and concentrate the supernatant into a clear extract;

[0014] (3) Add the refined honey and rock sugar, continue to concentrate until it becomes a thick paste, mix well, and package.

[0015] Preferably, the decoction is performed three times: first, 10 times the amount of water is added and the decoction is performed for 1.5 hours; second, 8 times the amount of water is added and the decoction is performed for 1 hour; and third, 6 times the amount of water is added and the decoction is performed for 0.5 hours.

[0016] Preferably, the concentration is carried out under reduced pressure, at a temperature of 60-70°C and a vacuum degree of 0.08-0.1 MPa.

[0017] This invention also provides the use of Shenqi Rongshu Ointment in the preparation of a medicine for improving poor appetite, poor mental state, and anemia after surgery for malignant tumors, reducing postoperative drainage, and promoting wound healing.

[0018] This ginseng, astragalus, and atractylodes ointment works by invigorating qi and nourishing blood, strengthening the spleen and stomach, soothing the liver and relieving depression, and stopping bleeding and astringing sores. The whole formula works to strengthen the body's resistance, remove blood stasis and promote new tissue growth, and astringe sores and stop bleeding.

[0019] • Principal herbs: Astragalus membranaceus, Angelica sinensis, and Ginseng. Astragalus membranaceus greatly tonifies the Qi of the spleen and lungs, strengthens Qi and consolidates the body, making it a holy medicine for tonifying Qi; Angelica sinensis tonifies and invigorates blood, making it a "holy medicine for blood"; Ginseng greatly tonifies the original Qi, restores the pulse and consolidates the body. When these three herbs are used together, they tonify both Qi and blood. When Qi is abundant, it can control blood; when blood is abundant, it can nourish the muscles.

[0020] • Assistant herbs: Rehmannia glutinosa (processed), Paeonia lactiflora, Spatholobus suberectus, Rhodiola rosea, Poria cocos, and Atractylodes macrocephala (fried). Rehmannia glutinosa nourishes yin and replenishes blood; Paeonia lactiflora nourishes blood and astringes yin; Spatholobus suberectus replenishes blood, invigorates blood circulation, unblocks meridians, and relieves pain. These three herbs work together to assist Angelica sinensis in replenishing blood; Rhodiola rosea invigorates qi, invigorates blood circulation, combats fatigue, and enhances immunity; Poria cocos and Atractylodes macrocephala (fried) strengthen the spleen and invigorate qi, assisting Astragalus membranaceus and Panax ginseng in their digestive functions. These six herbs work together to assist the principal herbs in invigorating qi and nourishing blood, strengthening the body's resistance and consolidating its

[0021] • Adjuvant herbs: Amomum villosum, Citrus reticulata peel, Cyperus rotundus, Aucklandia lappa, and Bletilla striata. Amomum villosum dispels dampness, invigorates the stomach, and promotes digestion; Citrus reticulata peel regulates qi and harmonizes the stomach; Cyperus rotundus soothes the liver and relieves depression; Aucklandia lappa promotes the flow of qi in the spleen and stomach; these four herbs regulate the flow of qi and prevent the cloying effects of tonifying herbs. Bletilla striata astringes, stops bleeding, reduces swelling, and promotes tissue regeneration, especially effective in promoting wound healing. Its mucilage can form a protective film on the wound surface, reducing exudation.

[0022] • Medicinal herb: Prepared licorice root, which invigorates qi, harmonizes the middle jiao, and balances the effects of other herbs.

[0023] The formula is comprehensive, with both nourishing and regulating properties. It replenishes both qi and blood, harmonizes the liver and spleen, and simultaneously stops bleeding and nourishes blood. This strengthens the spleen and stomach, ensuring a source for the generation of qi and blood. As a result, bleeding and exudation from the wound decrease, appetite increases, energy is boosted, anemia is corrected, and wounds heal quickly.

[0024] Compared with the prior art, the present invention has the following beneficial effects:

[0025] 1. Comprehensive coverage of core postoperative issues: It simultaneously improves poor appetite, poor mental state, anemia, reduces drainage, and promotes wound healing, filling the gap in "postoperative-specific" traditional Chinese medicine preparations.

[0026] 2. Stops bleeding without causing blood stasis: Bletilla striata has astringent and hemostatic properties, and can also promote tissue regeneration. Its mucilage can physically seal the tiny blood vessels in the wound, reducing exudation, and has no adverse effects on blood circulation, making it especially suitable for use in the early postoperative period.

[0027] 3. Nourishing blood and promoting blood circulation, clearing the meridians and relieving pain: Chicken blood vine, together with angelica and rehmannia, enhances the ability to nourish and promote blood circulation, improves the stagnation of qi and blood after surgery, promotes local blood circulation, and facilitates wound healing.

[0028] 4. Advantages of ointment dosage form: good taste (with honey and rock sugar to enhance flavor), convenient to take, especially suitable for patients with difficulty swallowing or weak gastrointestinal function after surgery; high drug concentration, small dosage per dose, easy to carry and long-term storage.

[0029] 5. Greatly replenishes vital energy and enhances immunity: Ginseng, astragalus, and rhodiola work together to quickly restore physical strength and improve resistance to infection.

[0030] 6. Regulates the liver and spleen, nourishing without causing stagnation: The four herbs Cyperus rotundus, Aucklandia lappa, Amomum villosum, and Citrus reticulata are used together to promote qi circulation and eliminate dampness, preventing the nourishing and greasy effects of tonifying herbs from hindering the stomach, while also improving postoperative emotional depression.

[0031] 7. Reasonable process and stable quality: Multiple decoctions, vacuum concentration and low temperature paste making are adopted to retain the effective ingredients to the maximum extent. The paste is delicate and easy to absorb. Detailed Implementation

[0032] The technical solution of the present invention will be further described in detail below with reference to specific embodiments.

[0033] Example 1

[0034] Prescription (based on 2980g of ointment):

[0035] The ingredients are as follows: 600g raw Astragalus membranaceus, 150g Angelica sinensis, 70g ginseng, 180g prepared Rehmannia glutinosa, 100g white peony root, 40g Rhodiola rosea, 200g Poria cocos, 120g stir-fried Atractylodes macrocephala, 100g Amomum villosum, 120g dried tangerine peel, 100g Cyperus rotundus, 100g Aucklandia lappa, 100g Bletilla striata, 200g Spatholobus suberectus, 50g prepared Glycyrrhiza uralensis, 500g honey, and 250g rock sugar.

[0036] The preparation method of Ginseng, Astragalus and Atractylodes Extract is as follows:

[0037] (1) Soak raw Astragalus membranaceus, Angelica sinensis, ginseng, Rehmannia glutinosa, Paeonia lactiflora, Rhodiola rosea, Poria cocos, stir-fried Atractylodes macrocephala, Cyperus rotundus, Aucklandia lappa, Bletilla striata, Spatholobus suberectus, and prepared Glycyrrhiza uralensis in 10 times the amount of water for 4

[0038] (2) First decoction: Add water to 10 times the volume, bring to a boil and simmer for 1.5 hours. Add cardamom and dried tangerine peel 8 minutes before the end of the decoction and filter.

[0039] (3) Second decoction: Add 8 times the amount of water to the dregs of the medicine, decoct for 1 hour, and filter.

[0040] (4) Third decoction: Add 6 times the amount of water to the dregs and decoct for 0.5 hours, then filter.

[0041] (5) Combine the three filtrates, let stand for 12 hours, take the supernatant and pass it through a 200-mesh sieve, and concentrate it under reduced pressure to a relative density of 1.12 (temperature 60-70℃, vacuum degree 0.08-0.1MPa).

[0042] (6) Add refined honey and rock sugar, continue to concentrate to a relative density of 1.38 (temperature 60-70℃, vacuum degree 0.08-0.1MPa), stir evenly, and package to obtain the product.

[0043] Dosage and administration: 20-20g (about one tablespoon) each time, 3 times a day, taken with warm water. Start taking it on the second day after surgery, and continue for 2-4 weeks as one course of treatment.

[0044] Example 2

[0045] Prescription (increase proportionally):

[0046] The ingredients are as follows: 800g raw Astragalus membranaceus, 200g Angelica sinensis, 100g ginseng, 200g prepared Rehmannia glutinosa, 120g white peony root, 50g Rhodiola rosea, 300g Poria cocos, 150g stir-fried Atractylodes macrocephala, 150g Amomum villosum, 150g dried tangerine peel, 150g Cyperus rotundus, 200g Aucklandia lappa, 150g Bletilla striata, 300g Spatholobus suberectus, 60g prepared Glycyrrhiza uralensis, 600g honey, and 300g rock sugar.

[0047] The preparation method of Shenqi Rongshu Ointment is the same as in Example 1.

[0048] Typical cases

[0049] Case 1: Mr. Li, male, 58 years old, on the 3rd day after osteosarcoma surgery, presented with fatigue, poor appetite, and only small amounts of liquids per day. He was pale, with a hemoglobin level of 95 g / L. Postoperative drainage was approximately 150 ml per day. He was given the ointment of this invention (prepared according to Example 1), 20 g each time, 3 times a day, dissolved in warm water. After 3 days of medication, his appetite improved significantly, and his mental state improved. After 7 days of medication, the drainage volume decreased to approximately 15 ml per day. After 14 days of medication, his hemoglobin level rose to 113 g / L, the wound healed well, and he was discharged as scheduled.

[0050] Case 2: Ms. Wang, 62 years old, was two days post-lumbar vertebrectomy for breast cancer with lumbar metastasis. She experienced extreme fatigue, lethargy, poor appetite, and low mood. Her hemoglobin level was 88 g / L, and postoperative drainage was approximately 180 ml per day. She took the ointment of this invention (prepared according to Example 1), 20 g each time, three times daily, dissolved in warm water. After 5 days of medication, her spirits improved and her appetite increased; after 10 days, the drainage volume decreased to approximately 20 ml per day; after 21 days, her hemoglobin level rose to 108 g / L, and the wound healed primarily.

[0051] Example 3

[0052] Prescription (reduced proportionally):

[0053] The ingredients are as follows: 300g raw Astragalus membranaceus, 100g Angelica sinensis, 40g ginseng, 150g prepared Rehmannia glutinosa, 80g white peony root, 30g Rhodiola rosea, 100g Poria cocos, 80g stir-fried Atractylodes macrocephala, 30g Amomum villosum, 100g dried tangerine peel, 50g Cyperus rotundus, 50g Aucklandia lappa, 50g Bletilla striata, 100g Spatholobus suberectus, 40g prepared Glycyrrhiza uralensis, 400g honey, and 200g rock sugar.

[0054] The preparation method of Shenqi Rongshu Ointment is the same as in Example 1.

[0055] Through the case studies in Examples 1, 2, and 3, it is demonstrated that the ointment of the present invention can significantly improve poor appetite, poor mental state, and anemia in patients after surgery for malignant tumors, reduce postoperative drainage volume, promote wound healing, and improve the quality of life of patients.

[0056] This invention has the following innovative features:

[0057] 1. For the first time, the four methods of "tonifying qi and nourishing blood, strengthening the spleen and stomach, soothing the liver and relieving depression, and astringing and stopping bleeding" were proposed to specifically target the complex pathogenesis of "deficiency, stagnation, depression and exudation" after surgery for malignant tumors.

[0058] 2. Hemostatic and tissue-regenerating drugs with Bletilla striata as the core: Bletilla striata has a mild and long-lasting astringent and hemostatic effect, and is especially suitable for postoperative wound bleeding and exudation, without increasing the risk of bleeding, and has a higher safety.

[0059] 3. Chicken blood vine, in synergy with angelica and rehmannia: enhances the blood-nourishing and blood-activating effects, while improving postoperative blood stasis and promoting local microcirculation.

[0060] 4. Innovative ointment formulation: It has a good taste, is absorbed quickly, and is easy to carry, filling the gap in postoperative ointment formulations.

[0061] 5. The formula is refined, with clear distinctions between the principal, assistant, adjuvant, and guide herbs: the 15 herbs are carefully combined and clinically proven to be effective.

[0062] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A ginseng, astragalus, and atractylodes ointment, characterized in that, This Ginseng, Astragalus, and Atractylodes Ointment is made from main ingredients and pharmaceutically acceptable excipients. The main ingredients include the following raw materials in parts by weight: raw Astragalus membranaceus 30-80; Angelica sinensis 10-20; ginseng 4-10; Rehmannia glutinosa 15-20; Paeonia lactiflora 8-12; Rhodiola rosea 3-5; Poria cocos 10-30; stir-fried Atractylodes macrocephala 8-15; Amomum villosum 3-15; Citrus reticulata 10-15; Cyperus rotundus 5-15; Aucklandia lappa 5-20; Bletilla striata 5-15; Spatholobus suberectus 10-30; and prepared Glycyrrhiza uralensis 4-6.

2. The ginseng, astragalus, and atractylodes ointment according to claim 1, characterized in that, The auxiliary ingredients are honey and rock sugar.

3. The ginseng, astragalus, and atractylodes ointment according to claim 1, characterized in that, The main ingredients include the following raw medicinal materials in parts by weight: Astragalus membranaceus 60g; Angelica sinensis 15g; Ginseng 7g; Rehmannia glutinosa 18g; Paeonia lactiflora 10g; Rhodiola rosea 4g; Poria cocos 20g; Atractylodes macrocephala 12g; Amomum villosum 10g; Citrus reticulata 12g; Cyperus rotundus 10g; Aucklandia lappa 10g; Bletilla striata 10g; Spatholobus suberectus 20g; Glycyrrhiza uralensis 5g.

4. A ginseng, astragalus, and atractylodes ointment according to any one of claims 1 to 3, characterized in that, The auxiliary material consists of the following ingredients in parts by weight: honey 400-600; rock sugar 200-300.

5. A method for preparing a ginseng, astragalus, and atractylodes extract, characterized in that, The ginseng, astragalus, and atractylodes ointment uses the ginseng, astragalus, and atractylodes ointment as described in any one of claims 1 to 4, and its preparation method includes the following steps: (1) Soak raw Astragalus membranaceus, Angelica sinensis, ginseng, Rehmannia glutinosa, Paeonia lactiflora, Rhodiola rosea, Poria cocos, stir-fried Atractylodes macrocephala, Cyperus rotundus, Aucklandia lappa, Bletilla striata, Spatholobus suberectus, and prepared Glycyrrhiza uralensis in water and decoct them 2-3 times. Add Amomum villosum and Citrus reticulata 5-10 minutes before the end of the first decoction. (2) Combine the decoctions, filter, let stand, and concentrate the supernatant into a clear extract; (3) Add the refined honey and rock sugar, continue to concentrate until it becomes a thick paste, mix well, and package.

6. The preparation method of the Ginseng, Astragalus, and Atractylodes Extract according to claim 5, characterized in that, The decoction is performed three times: first, add 10 times the amount of water and boil for 1.5 hours; second, add 8 times the amount of water and boil for 1 hour; and third, add 6 times the amount of water and boil for 0.5 hours.

7. The preparation method of the Ginseng, Astragalus, and Atractylodes Extract according to claim 5, characterized in that, The concentration is carried out under reduced pressure at a temperature of 60-70℃ and a vacuum degree of 0.08-0.1MPa.

8. The use of the Ginseng and Astragalus Extract Ointment according to any one of claims 1 to 4 in the preparation of a medicine for improving poor appetite, poor mental state, and anemia after surgery for malignant tumors, reducing postoperative drainage, and promoting wound healing.