A new type of eaglewood moxibustion for promoting blood flow, relieving depression and removing blood stasis and a preparation method thereof

Abstract

The present application belongs to the field of eaglewood moxibustion, and particularly relates to a novel eaglewood moxibustion for dredging channels, relieving depression and removing blood stasis and a preparation method thereof. Eaglewood and green tea are crushed, mixed with a sodium sulfite solution to soften, and a mixture of pollen, dried tangerine or orange peel and curcuma is soaked in sweet almond oil with good biocompatibility. The effective components of the prepared eaglewood compound can be quickly released and absorbed, and have the effect of dredging channels, relieving depression and removing blood stasis. The polymer particle mixed matrix glue solution formed by spray drying has strong adhesion of the modified yellow potato glue polymer adhesive, and maintains the stability of each component. The film forming agent mixed with the antioxidant stabilizer is coated on the surface layer of the cylindrical eaglewood moxibustion, and the prepared novel eaglewood moxibustion for dredging channels, relieving depression and removing blood stasis does not need to be ignited, does not produce irritating smoke, the effective components are quickly released after heating, does not harm skin cells and is easy to absorb, and has a long storage time.

Description

Technical Field

[0001] This invention belongs to the field of agarwood moxibustion preparation, specifically referring to a novel agarwood moxibustion for clearing the meridians, relieving depression, and removing blood stasis, and its preparation method. Background Technology

[0002] Plant-based moxibustion sticks are made by rolling raw materials into cylindrical strips. When using them, incense is used to light the plant fibers, and the moxibustion stick is placed three centimeters away from the skin for heating. The heat generated by the burning plant fibers and the volatile substances released after burning stimulate the meridians and acupoints. When a burning sensation is felt on the skin, the moxibustion stick is immediately extinguished, and a new set of moxibustion sticks is used to continue the operation.

[0003] When plant-based moxibustion sticks are burned, they provide local stimulation to the body, enhancing local blood and lymphatic circulation, strengthening the metabolic capacity of skin tissue, and causing the diffusion of inhibitory substances in the cerebral cortex, reducing the excitability of the nervous system and relieving chronic pain.

[0004] Currently, existing plant-based moxibustion stick preparation technologies mainly suffer from the following problems: First, when plant-based moxibustion sticks are burned and applied to the skin, the smoke contains low levels of active ingredients, requiring prolonged application to be effective. Prolonged high temperatures can cause blisters on the skin, which can rupture and lead to infection. The smoke produced during combustion can also irritate the respiratory tract. Second, skin cells may react negatively to the components in the moxibustion stick, causing skin damage and resulting in itching and swelling after use. Third, storage conditions are critical. During storage, the active ingredients in the plant-based moxibustion sticks may oxidize, and moisture in the air can cause the outer surface of the moxibustion sticks to deteriorate and mold. Furthermore, combustion can produce toxic substances that can negatively impact health. Summary of the Invention

[0005] In response to the above situation and to overcome the shortcomings of the existing technology, this invention provides a novel agarwood moxibustion for promoting blood circulation, relieving depression, and removing blood stasis, as well as its preparation method. To solve the problems of low content of effective ingredients in the smoke, skin damage from high-temperature fumigation, respiratory irritation from smoke, rejection reaction, and mold growth and deterioration of the moxibustion body, this invention uses an agarwood complex mixed with a sweet potato gum polymer adhesive. After pressing and molding, the surface is coated with an antioxidant and stabilizing coating liquid. The resulting novel agarwood moxibustion for promoting blood circulation, relieving depression, and removing blood stasis does not require ignition, produces no smoke, does not cause rejection reaction in skin cells, has a rapid onset of action, and is easy to store.

[0006] To achieve the above objectives, the technical solution adopted by the present invention is as follows: The present invention proposes a novel agarwood moxibustion for promoting blood circulation, relieving stagnation, and removing blood stasis, comprising the following components in parts by weight: The composition includes: 280-320 parts agarwood complex, 130-180 parts sweet potato gum polymer adhesive, 30-60 parts thymol, 25-45 parts costunolide, 10-20 parts polyacrylamide, 30-40 parts ethyl acetate, 20-30 parts polyethylene glycol monomethyl ether methacrylate, 70-90 parts casein phosphopeptide, 100-120 parts anhydrous ethanol, and 110-130 parts ultrapure water.

[0007] Preferably, the preparation method of the agarwood complex specifically includes the following steps: S1. Weigh 200-300 parts by weight of agarwood and 100-120 parts by weight of styrax. Use a drying oven with a power of 2.5-3 kW, a drying temperature of 110-120℃, and a drying time of 30-40 min. After drying, put the dried agarwood into a pulverizer with a power of 1.2-1.5 kW, a pulverizing temperature of 25-28℃, a pulverizing time of 20-25 min, and a pulverizing speed of 1500-1900 r / min to obtain wood pulverizer. S2. Weigh 25-30 parts by weight of sodium sulfite, mix with 150-180 parts of ultrapure water, put into a stirrer with a power of 1.3-1.6kW, stir at a temperature of 40-60℃, stir for 10-15 min, stir at a speed of 160-180 r / min, and stir to obtain a sodium sulfite solution. S3. Place the wood pulverizer from S1 into the sodium sulfite solution prepared in S2, stir at a temperature of 30-35℃ for 15-20 min, and at a speed of 320-340 r / min to mix and obtain the pulverized mixture. S4. Weigh out 70-90 parts by weight of cattail pollen, 50-80 parts of dried tangerine peel, and 60-65 parts of turmeric. Place them in a drying oven with a power of 2.5-3 kW, dry at a temperature of 60-70℃ for 20-25 minutes. After drying, place them in a grinder with a power of 1.2-1.5 kW, grind for 20-30 minutes, grind at a temperature of 20-23℃, and grind at a speed of 1800-2200 r / min. After grinding, mix them with 300-350 parts of sweet almond oil in a mixer with a power of 1.3-1.6 kW, mix at a temperature of 35-40℃ for 20-25 minutes, and mix at a speed of 110-130 r / min. Mix well and soak at a constant temperature for 3-4 hours to obtain active aromatic oil. S5. Place the pulverized mixture prepared in S3 and the active aromatic oil prepared in S4 into a grinder with a power of 1.8-2 kW. The grinding temperature is 60-65℃, the grinding time is 20-30 min, and the grinding speed is 1400-1800 r / min. After grinding, the agarwood complex is obtained.

[0008] Preferably, the preparation method of the sweet potato gum polymer adhesive specifically includes the following steps: L1. Weigh 115-130 parts by weight of sweet potato gum and dissolve it in 200-230 parts by weight of ultrapure water to form a matrix gum solution. L2. Weigh 60-80 parts by weight of vinyl acetate resin, 40-55 parts by weight of hydroquinone, 30-38 parts by weight of polymethyl methacrylate and 180-220 parts by weight of anhydrous ethanol, and place them in a constant temperature stirring pot with a power of 2.2-2.4 kW. The stirring temperature is 65-70℃, the stirring time is 10-20 min, and the stirring speed is 160-180 r / min. Polymerization occurs during heating and stirring. Then, the mixture is placed in a spray dryer with a power of 2.8-3.2 kW. The spray drying temperature is 110-130℃, the spray drying time is 25-30 s, and the spray drying particle size is 5-8 mm. The polymer particles are obtained by spray drying. L3. Place the polymer particles prepared in L2 and the matrix adhesive solution prepared in L1 into a stirring and heating pot with a power of 1.6-1.8 kW. The stirring and heating temperature is 45-60℃, the stirring and heating time is 15-25 min, and the stirring and heating speed is 140-160 r / min. After stirring and mixing, keep warm and modify for 2-3 h to obtain the sweet potato gum polymer adhesive.

[0009] This invention also proposes a method for preparing a novel agarwood moxibustion for promoting blood circulation, relieving depression, and removing blood stasis, which specifically includes the following steps: Step 1: Place the agarwood complex and sweet potato gum polymer binder into a mixer with a power of 1.3-1.6 kW, a stirring temperature of 30-33℃, a stirring time of 20-30 min, and a stirring speed of 240-260 r / min, and stir until uniform to obtain a mixture. Step 2: Place the mixture prepared in Step 1 into a pressure molding machine with a power of 10-12 kW, press it with a molding pressure of 1.5-1.8 kN, a molding temperature of 100-108℃, a molding time of 25-35 min, a molding length of 18-26 cm, and a molding diameter of 1.8-2.2 cm. After molding, a cylindrical agarwood moxa stick is obtained. Step 3: Place thymol, costunol, polyacrylamide, ethyl acetate, and anhydrous ethanol into a mixer with a power of 1.3-1.6 kW, at a stirring temperature of 25-30℃, for a stirring time of 10-15 min, and at a stirring speed of 180-220 r / min, and mix to obtain an antioxidant stabilizer. Step 4: Place polyethylene glycol monomethyl ether methacrylate, casein phosphopeptide, and ultrapure water into a mixer with a power of 1.3-1.6 kW, mix at a temperature of 28-32℃ for 13-16 min and a speed of 170-180 r / min to obtain a film-forming agent. Step 5: Add the film preparation agent prepared in Step 4 to the antioxidant stabilizer prepared in Step 3. Stir at a temperature of 32-35℃ for 18-26 minutes and at a speed of 210-220 r / min until homogeneous to obtain the antioxidant stabilizing coating solution. Step Six: Place the cylindrical agarwood moxibustion prepared in Step Two into the antioxidant and stabilizing coating solution prepared in Step Five. The soaking temperature is 28-32℃, and the soaking time is 10-20 seconds. After soaking, remove it and place it in a constant temperature drying oven with a power of 1.4-1.8 kW. The constant temperature drying temperature is 65-75℃, and the constant temperature drying time is 8-12 minutes. The new type of agarwood moxibustion that promotes blood circulation, relieves depression, and removes blood stasis is obtained.

[0010] The beneficial effects achieved by this invention are as follows: This invention uses dried agarwood and pine resin, which are then pulverized. Agarwood and pine resin contain agaricone, agaric spirol, aristolochic acid, and magnolia alkaloids, which have blood-activating, stasis-removing, sedative, and tranquilizing effects. The wood pulverized material is mixed with a sodium sulfite solution to soften the cellulose in the pulverized material, facilitating the release of the effective components in agarwood and pine resin. Powdered cattail pollen, dried tangerine peel, and turmeric are soaked in sweet almond oil with good biocompatibility. The active aromatic oil is then ground with the pulverized mixture to release a large amount of effective volatile components, which remain stably present in the sweet almond oil, resulting in not only a high concentration of effective components but also strong cell penetration. Vinyl acetate gum, hydroquinone, and polymethyl methacrylate are dissolved and spray-dried to form polymer particles, which are then mixed with the matrix gum solution. After heat insulation modification, a sweet potato gum polymer adhesive with tight intermolecular connections and strong adhesiveness is obtained. This adhesive can tightly bind the components of the novel agarwood moxibustion for promoting blood circulation, relieving depression, and removing blood stasis, maintaining the stability of each component. Furthermore, the hydroquinone produces acidity upon heating, which, in conjunction with sodium sulfite solution and sweet almond oil, further accelerates the rapid release and absorption of the active ingredients during use. A film-forming agent containing polyethylene glycol monomethyl ether methacrylate and casein phosphopeptide, along with an antioxidant stabilizer with antioxidant and stabilizing effects, is mixed and coated onto the surface of the cylindrical agarwood moxibustion. The resulting novel agarwood moxibustion for promoting blood circulation, relieving depression, and removing blood stasis does not require ignition, does not produce irritating smoke, releases active ingredients rapidly after heating, is quickly absorbed upon application to the target area, does not harm skin cells, has tightly bound components, and has a long shelf life. Attached Figure Description

[0011] To more clearly illustrate the technical solutions in this invention or the prior art, the following description will be provided in a clear and easy-to-understand manner in conjunction with the accompanying drawings. Obviously, the drawings described below are merely for this invention, and those skilled in the art can obtain other drawings based on these drawings without any creative effort.

[0012] Figure 1 This is a graph showing the results of whole blood viscosity in mice as described in Experimental Example 1 of this invention; Figure 2 This is a graph showing the electrophoresis time results of mouse erythrocytes as described in Experiment Example 1 of this invention; Figure 3 This is a graph showing the results of 5-hydroxytryptamine content in mice as described in Experimental Example 1 of this invention; Figure 4 This is a graph showing the in vivo norepinephrine content results as described in Experimental Example 1 of the present invention; Figure 5 This is a graph showing the total bacterial count results at 25°C as described in Experimental Example 2 of this invention. Figure 6 This is a graph showing the total bacterial count at 37°C as described in Experimental Example 2 of this invention. Detailed Implementation

[0013] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0014] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those familiar to those skilled in the art. Furthermore, any methods and materials similar to or equivalent to those described herein may be applied to this invention. The preferred embodiments and materials described herein are for illustrative purposes only and do not limit the scope of this application.

[0015] Unless otherwise specified, the experimental methods used in the following examples are conventional methods; unless otherwise specified, the experimental materials and test strains used in the following examples were purchased from commercial channels.

[0016] Example 1: This example provides a novel agarwood moxibustion for promoting blood circulation, relieving depression, and removing blood stasis, and its preparation method. The novel agarwood moxibustion for promoting blood circulation, relieving depression, and removing blood stasis comprises the following components in parts by weight: The composition includes 280 parts agarwood complex, 130 parts sweet potato gum polymer adhesive, 30 parts thymol, 25 parts costunolide, 10 parts polyacrylamide, 30 parts ethyl acetate, 20 parts polyethylene glycol monomethyl ether methacrylate, 70 parts casein phosphopeptide, 100 parts anhydrous ethanol, and 110 parts ultrapure water.

[0017] The preparation method of the agarwood complex specifically includes the following steps: S1. Weigh 200 parts by weight of agarwood and 100 parts by weight of styrax, use a drying oven with a power of 2.5 kW, dry at a temperature of 110℃ for 30 min, and then put them into a pulverizer with a power of 1.2 kW, pulverize at a temperature of 25℃ for 20 min, and pulverize at a speed of 1500 r / min to obtain wood pulverizer. S2. Weigh 25 parts by weight of sodium sulfite, mix with 150 parts of ultrapure water, put into a 1.3 kW mixer, stir at 40℃ for 10 min, stir at 160 r / min to obtain sodium sulfite solution. S3. Place the wood pulverizer from S1 into the sodium sulfite solution prepared in S2, stir at 30°C for 15 min, and stir at 320 r / min to obtain the pulverized mixture. S4. Weigh out 70 parts by weight of cattail pollen, 50 parts by weight of dried tangerine peel, and 60 parts by weight of turmeric. Place them in a drying oven with a power of 2.5 kW, dry at 60℃ for 20 min. After drying, place them in a grinder with a power of 1.2 kW, grind for 20 min, grind at 20℃, and grind at 1800 r / min. After grinding, mix them with 300 parts by weight of sweet almond oil in a mixer with a power of 1.3 kW, mix at 35℃ for 20 min, and mix at 110 r / min. Mix well and soak at a constant temperature for 3 h to obtain active aromatic oil. S5. The pulverized mixture prepared in S3 and the active aromatic oil prepared in S4 are placed in a 1.8 kW grinder. The grinding temperature is 60℃, the grinding time is 20 min, and the grinding speed is 1400 r / min. After grinding, the agarwood complex is obtained.

[0018] The preparation method of the sweet potato gum polymer adhesive specifically includes the following steps: L1. Weigh 115 parts by weight of sweet potato gum and dissolve it in 200 parts by weight of ultrapure water to form a matrix gum solution. L2. Weigh 60 parts by weight of vinyl acetate resin, 40 parts by weight of hydroquinone, 30 parts by weight of polymethyl methacrylate and 180 parts by weight of anhydrous ethanol, and place them in a constant temperature stirring pot with a power of 2.2 kW. The stirring temperature is 65℃, the stirring time is 10 min, and the stirring speed is 160 r / min. Polymerization occurs during heating and stirring. Then, the mixture is placed in a spray dryer with a power of 2.8 kW. The spray drying temperature is 110℃, the spray drying time is 25 s, and the spray dried particle size is 5 mm. The polymer particles are obtained by spray drying. L3. The polymer particles prepared in L2 and the matrix adhesive solution prepared in L1 were placed in a stirring and heating pot with a power of 1.6 kW. The stirring and heating temperature was 45℃, the stirring and heating time was 15 min, and the stirring and heating speed was 140 r / min. After stirring and mixing, the mixture was kept at the temperature for 2 h to obtain the sweet potato gum polymer adhesive.

[0019] This embodiment also proposes a method for preparing a novel agarwood moxibustion for promoting blood circulation, relieving depression, and removing blood stasis, which specifically includes the following steps: Step 1: Place the agarwood complex and sweet potato gum polymer binder into a 1.3 kW mixer, mix at 30°C for 20 min at 240 r / min until homogeneous to obtain a mixture. Step 2: Place the mixture of contents prepared in Step 1 into a 10 kW pressure molding machine, press it at a pressure of 1.5 kN, a pressing temperature of 100℃, a pressing time of 25 min, a pressing length of 18 cm, and a pressing diameter of 1.8 cm. After pressing, a cylindrical agarwood moxa stick is obtained. Step 3: Place thymol, costunol, polyacrylamide, ethyl acetate, and anhydrous ethanol into a 1.3kW mixer, stir at 25℃ for 10 min at 180 r / min to obtain an antioxidant stabilizer. Step 4: Place polyethylene glycol monomethyl ether methacrylate, casein phosphopeptide, and ultrapure water into a 1.3 kW mixer, mix at 28°C for 13 min at 170 r / min to obtain a film-forming agent. Step 5: Add the film-forming agent prepared in Step 4 to the antioxidant stabilizer prepared in Step 3. Stir at 32°C for 18 minutes and at 210 r / min until homogeneous to obtain the antioxidant stabilizing coating solution. Step 6: Place the cylindrical agarwood moxibustion prepared in Step 2 into the antioxidant and stabilizing coating solution prepared in Step 5. The soaking temperature is 28℃ and the soaking time is 10 seconds. After soaking, take it out and place it in a constant temperature drying oven with a power of 1.4 kW. The constant temperature drying temperature is 65℃ and the constant temperature drying time is 8 minutes to obtain a new type of agarwood moxibustion that promotes blood circulation, relieves depression and removes blood stasis.

[0020] Example 2: This example provides a novel agarwood moxibustion for promoting blood circulation, relieving depression, and removing blood stasis, and its preparation method. The novel agarwood moxibustion for promoting blood circulation, relieving depression, and removing blood stasis comprises the following components in parts by weight: The composition includes 300 parts agarwood complex, 160 parts sweet potato gum polymer adhesive, 50 parts thymol, 35 parts costunolide, 15 parts polyacrylamide, 35 parts ethyl acetate, 25 parts polyethylene glycol monomethyl ether methacrylate, 80 parts casein phosphopeptide, 110 parts anhydrous ethanol, and 120 parts ultrapure water.

[0021] The preparation method of the agarwood complex specifically includes the following steps: S1. Weigh 250 parts by weight of agarwood and 110 parts by weight of styrax. Use a drying oven with a power of 2.8 kW, a drying temperature of 115℃, and a drying time of 35 min. After drying, put them into a pulverizer with a power of 1.4 kW, a pulverizing temperature of 27℃, a pulverizing time of 23 min, and a pulverizing speed of 1700 r / min. After pulverizing, obtain wood pulverizer. S2. Weigh 28 parts by weight of sodium sulfite, mix with 170 parts by weight of ultrapure water, put into a 1.5 kW mixer, stir at 50℃ for 13 min, stir at 170 r / min to obtain sodium sulfite solution. S3. Place the wood pulverizer from S1 into the sodium sulfite solution prepared in S2, stir at 33°C for 18 min, and stir at 330 r / min to obtain the pulverized mixture. S4. Weigh out 80 parts by weight of cattail pollen, 70 parts by weight of dried tangerine peel, and 63 parts by weight of turmeric. Place them in a drying oven with a power of 2.8 kW, dry at 65℃ for 23 min. After drying, place them in a grinder with a power of 1.4 kW for 25 min, grind at 22℃, and grind at 2000 r / min. After grinding, mix them with 330 parts by weight of sweet almond oil in a mixer with a power of 1.5 kW, mix at 38℃ for 23 min, and mix at 120 r / min. Mix well and soak at a constant temperature for 3.5 h to obtain active aromatic oil. S5. The pulverized mixture prepared in S3 and the active aromatic oil prepared in S4 are placed in a 1.9 kW mill. The milling temperature is 63℃, the milling time is 25 min, and the milling speed is 1600 r / min. After milling, the agarwood complex is obtained.

[0022] The preparation method of the sweet potato gum polymer adhesive specifically includes the following steps: L1. Weigh 125 parts by weight of sweet potato gum and dissolve it in 220 parts by weight of ultrapure water to form a matrix gum solution. L2. Weigh 70 parts by weight of vinyl acetate resin, 45 parts by weight of hydroquinone, 35 parts by weight of polymethyl methacrylate and 200 parts by weight of anhydrous ethanol, and put them into a constant temperature stirring pot with a power of 2.3 kW. The stirring temperature is 68℃, the stirring time is 15 min, and the stirring speed is 170 r / min. Polymerization occurs during heating and stirring. Then, the mixture is put into a spray dryer with a power of 3 kW. The spray drying temperature is 120℃, the spray drying time is 28 s, and the spray dried particle size is 7 mm. The polymer particles are obtained by spray drying. L3. The polymer particles prepared in L2 and the matrix adhesive solution prepared in L1 were placed in a stirring and heating pot with a power of 1.7 kW. The stirring and heating temperature was 55℃, the stirring and heating time was 20 min, and the stirring and heating speed was 150 r / min. After stirring and mixing, the mixture was kept at the temperature for 2.5 h to obtain the sweet potato gum polymer adhesive.

[0023] This embodiment also proposes a method for preparing a novel agarwood moxibustion for promoting blood circulation, relieving depression, and removing blood stasis, which specifically includes the following steps: Step 1: Place the agarwood complex and sweet potato gum polymer binder into a 1.5 kW mixer, mix at 32°C for 25 min at 250 r / min, and mix until homogeneous to obtain a mixture. Step 2: Place the mixture of contents prepared in Step 1 into a pressure molding machine with a power of 11 kW, press the molding pressure at 1.6 kN, press the molding temperature at 104℃, press the molding time at 30 min, press the molding length at 23 cm, press the molding diameter at 2 cm, and obtain a cylindrical agarwood moxa stick after pressing. Step 3: Place thymol, costunol, polyacrylamide, ethyl acetate, and anhydrous ethanol into a 1.5kW mixer, stir at 28℃ for 13 minutes, and at 200 r / min to obtain an antioxidant stabilizer. Step 4: Place polyethylene glycol monomethyl ether methacrylate, casein phosphopeptide, and ultrapure water into a 1.5 kW mixer, mix at 30°C for 15 min at 175 r / min to obtain a film-forming agent. Step 5: Add the film-forming agent prepared in Step 4 to the antioxidant stabilizer prepared in Step 3. Stir at 34°C for 23 minutes and at 210 r / min until homogeneous to obtain the antioxidant stabilizing coating solution. Step 6: Place the cylindrical agarwood moxibustion prepared in Step 2 into the antioxidant and stabilizing coating solution prepared in Step 5. The soaking temperature is 30℃ and the soaking time is 15 seconds. After soaking, take it out and place it in a constant temperature drying oven with a power of 1.6 kW. The constant temperature drying temperature is 70℃ and the constant temperature drying time is 10 minutes to obtain a new type of agarwood moxibustion that promotes blood circulation, relieves depression and removes blood stasis.

[0024] Example 3: This example provides a novel agarwood moxibustion for promoting blood circulation, relieving depression, and removing blood stasis, and its preparation method. The novel agarwood moxibustion for promoting blood circulation, relieving depression, and removing blood stasis comprises the following components in parts by weight: The composition includes 320 parts agarwood complex, 180 parts sweet potato gum polymer adhesive, 60 parts thymol, 45 parts costunolide, 20 parts polyacrylamide, 40 parts ethyl acetate, 30 parts polyethylene glycol monomethyl ether methacrylate, 90 parts casein phosphopeptide, 120 parts anhydrous ethanol, and 130 parts ultrapure water.

[0025] The preparation method of the agarwood complex specifically includes the following steps: S1. Weigh 300 parts by weight of agarwood and 120 parts by weight of styrax, use a 3 kW drying oven, dry at 120℃ for 40 min, and then put them into a 1.5 kW pulverizer. Pulverize at 28℃ for 25 min and at 1900 r / min to obtain wood pulverizer. S2. Weigh 30 parts by weight of sodium sulfite, mix with 180 parts of ultrapure water, put into a 1.6 kW mixer, stir at 60℃ for 15 min, stir at 180 r / min to obtain sodium sulfite solution. S3. Place the wood pulverizer from S1 into the sodium sulfite solution prepared in S2, stir at 35°C for 20 min, and at 340 r / min to mix and obtain the pulverized mixture. S4. Weigh out 90 parts by weight of cattail pollen, 80 parts by weight of dried tangerine peel, and 65 parts by weight of turmeric. Place them in a drying oven with a power of 3 kW, dry at 70℃ for 25 min. After drying, place them in a grinder with a power of 1.5 kW for 30 min, grind at 23℃, and grind at 2200 r / min. After grinding, mix them with 350 parts by weight of sweet almond oil in a mixer with a power of 1.6 kW, mix at 40℃ for 25 min, and mix at 130 r / min. Mix well and soak at a constant temperature for 4 h to obtain active aromatic oil. S5. The pulverized mixture prepared in S3 and the active aromatic oil prepared in S4 are placed in a 2 kW grinding mill. The grinding temperature is 65℃, the grinding time is 30 min, and the grinding speed is 1800 r / min. After grinding, the agarwood complex is obtained.

[0026] The preparation method of the sweet potato gum polymer adhesive specifically includes the following steps: L1. Weigh 130 parts by weight of sweet potato gum and dissolve it in 230 parts by weight of ultrapure water to form a matrix gum solution. L2. Weigh 80 parts by weight of vinyl acetate resin, 55 parts by weight of hydroquinone, 38 parts by weight of polymethyl methacrylate and 220 parts by weight of anhydrous ethanol, and place them in a constant temperature stirring pot with a power of 2.4 kW. The stirring temperature is 70℃, the stirring time is 20 min, and the stirring speed is 180 r / min. Polymerization occurs during heating and stirring. Then, the mixture is placed in a spray dryer with a power of 3.2 kW. The spray drying temperature is 130℃, the spray drying time is 30 s, and the spray dried particle size is 8 mm. The polymer particles are obtained by spray drying. L3. The polymer particles prepared in L2 and the matrix adhesive solution prepared in L1 were placed in a stirring and heating pot with a power of 1.8 kW. The stirring and heating temperature was 60℃, the stirring and heating time was 25 min, and the stirring and heating speed was 160 r / min. After stirring and mixing, the mixture was kept at the temperature for 3 h to obtain the sweet potato gum polymer adhesive.

[0027] This embodiment also proposes a method for preparing a novel agarwood moxibustion for promoting blood circulation, relieving depression, and removing blood stasis, which specifically includes the following steps: Step 1: Place the agarwood complex and sweet potato gum polymer binder into a 1.6 kW mixer, mix at 33°C for 30 min at 260 r / min, and mix until homogeneous to obtain a mixture. Step 2: Place the mixture of contents prepared in Step 1 into a 12 kW pressure molding machine, press it at a pressure of 1.8 kN, a temperature of 108℃, a pressing time of 35 min, a pressing length of 26 cm, and a pressing diameter of 2.2 cm. After pressing, a cylindrical agarwood moxa stick is obtained. Step 3: Place thymol, costunol, polyacrylamide, ethyl acetate, and anhydrous ethanol into a 1.6kW mixer, stir at 30℃ for 15 min at 220 r / min, and mix to obtain an antioxidant stabilizer. Step 4: Place polyethylene glycol monomethyl ether methacrylate, casein phosphopeptide, and ultrapure water into a 1.6 kW mixer, mix at 32°C for 16 min at 180 r / min to obtain a film-forming agent. Step 5: Add the film-forming agent prepared in Step 4 to the antioxidant stabilizer prepared in Step 3. Stir at 35°C for 26 minutes and at 220 r / min until homogeneous to obtain the antioxidant stabilizing coating solution. Step Six: Place the cylindrical agarwood moxibustion prepared in Step Two into the antioxidant and stabilizing coating solution prepared in Step Five. The soaking temperature is 32℃ and the soaking time is 20 seconds. After soaking, remove it and place it in a constant temperature drying oven with a power of 1.8 kW. The constant temperature drying temperature is 75℃ and the constant temperature drying time is 12 minutes to obtain a new type of agarwood moxibustion that promotes blood circulation, relieves depression and removes blood stasis.

[0028] Example 4: This example provides a novel agarwood moxibustion for promoting blood circulation, relieving depression, and removing blood stasis, and its preparation method. The novel agarwood moxibustion for promoting blood circulation, relieving depression, and removing blood stasis comprises the following components in parts by weight: The composition of the product is as follows: 290 parts agarwood complex, 150 parts sweet potato gum polymer adhesive, 40 parts thymol, 30 parts costunolide, 13 parts polyacrylamide, 32 parts ethyl acetate, 24 parts polyethylene glycol monomethyl ether methacrylate, 75 parts casein phosphopeptide, 108 parts anhydrous ethanol, and 116 parts ultrapure water.

[0029] The preparation method of the agarwood complex specifically includes the following steps: S1. Weigh 230 parts by weight of agarwood and 105 parts by weight of styrax. Use a drying oven with a power of 2.7 kW, a drying temperature of 112℃, and a drying time of 33 min. After drying, put them into a pulverizer with a power of 1.3 kW, a pulverizing temperature of 26℃, a pulverizing time of 21 min, and a pulverizing speed of 1600 r / min to obtain wood pulverizer. S2. Weigh 27 parts by weight of sodium sulfite, mix with 160 parts of ultrapure water, put into a 1.4 kW mixer, stir at 48℃ for 12 min, stir at 160 r / min to obtain sodium sulfite solution. S3. Place the wood pulverizer from S1 into the sodium sulfite solution prepared in S2, stir at 32°C for 17 min, and stir at 320 r / min to obtain the pulverized mixture. S4. Weigh out 75 parts by weight of cattail pollen, 60 parts by weight of dried tangerine peel, and 62 parts by weight of turmeric. Place them in a drying oven with a power of 2.7 kW, dry at 63℃ for 21 min. After drying, place them in a grinder with a power of 1.3 kW for 24 min, grind at 21℃, and grind at 1900 r / min. After grinding, mix them with 320 parts by weight of sweet almond oil in a mixer with a power of 1.4 kW, mix at 36℃ for 23 min, and mix at 120 r / min. Mix well and soak at a constant temperature for 3.2 h to obtain active aromatic oil. S5. The pulverized mixture prepared in S3 and the active aromatic oil prepared in S4 are placed in a 1.9 kW grinder. The grinding temperature is 62℃, the grinding time is 22 min, and the grinding speed is 1500 r / min. After grinding, the agarwood complex is obtained.

[0030] The preparation method of the sweet potato gum polymer adhesive specifically includes the following steps: L1. Weigh 120 parts by weight of sweet potato gum and dissolve it in 210 parts by weight of ultrapure water to form a matrix gum solution. L2. Weigh 65 parts by weight of vinyl acetate resin, 43 parts by weight of hydroquinone, 32 parts by weight of polymethyl methacrylate and 190 parts by weight of anhydrous ethanol, and place them in a constant temperature stirring pot with a power of 2.3 kW. The stirring temperature is 67℃, the stirring time is 12 min, and the stirring speed is 170 r / min. Polymerization occurs during heating and stirring. Then, the mixture is placed in a spray dryer with a power of 2.9 kW. The spray drying temperature is 115℃, the spray drying time is 27 s, and the spray dried particle size is 6 mm. The polymer particles are obtained by spray drying. L3. The polymer particles prepared by L2 and the matrix adhesive solution prepared by L1 were placed in a stirring and heating pot with a power of 1.7 kW. The stirring and heating temperature was 50℃, the stirring and heating time was 18 min, and the stirring and heating speed was 140 r / min. After stirring and mixing, the mixture was kept at the temperature for 2.3 h to obtain the sweet potato gum polymer adhesive.

[0031] This embodiment also proposes a method for preparing a novel agarwood moxibustion for promoting blood circulation, relieving depression, and removing blood stasis, which specifically includes the following steps: Step 1: Place the agarwood complex and sweet potato gum polymer binder into a 1.4 kW mixer, mix at 31°C for 23 min at 250 r / min, and mix until homogeneous to obtain a mixture. Step 2: Place the mixture of contents prepared in Step 1 into a pressure molding machine with a power of 11 kW, press the molding pressure at 1.6 kN, press the molding temperature at 102℃, press the molding time at 28 min, press the molding length at 20 cm, press the molding diameter at 1.9 cm, and obtain a cylindrical agarwood moxa stick after pressing. Step 3: Place thymol, costunol, polyacrylamide, ethyl acetate, and anhydrous ethanol into a 1.4kW mixer, stir at 27℃ for 12 minutes, and at 190 r / min to obtain an antioxidant stabilizer. Step 4: Place polyethylene glycol monomethyl ether methacrylate, casein phosphopeptide, and ultrapure water into a 1.4 kW mixer, mix at 29°C for 14 min at 172 r / min to obtain a film-forming agent. Step 5: Add the film preparation agent prepared in Step 4 to the antioxidant stabilizer prepared in Step 3. Stir at 33°C for 20 minutes and at 210 r / min until homogeneous to obtain the antioxidant stabilizing coating solution. Step 6: Place the cylindrical agarwood moxibustion prepared in Step 2 into the antioxidant and stabilizing coating solution prepared in Step 5. The soaking temperature is 29℃ and the soaking time is 13 seconds. After soaking, take it out and place it in a constant temperature drying oven with a power of 1.5 kW. The constant temperature drying temperature is 68℃ and the constant temperature drying time is 9 minutes to obtain a new type of agarwood moxibustion that promotes blood circulation, relieves depression and removes blood stasis.

[0032] Example 5: This example provides a novel agarwood moxibustion for promoting blood circulation, relieving depression, and removing blood stasis, and its preparation method. The novel agarwood moxibustion for promoting blood circulation, relieving depression, and removing blood stasis comprises the following components in parts by weight: The composition includes 310 parts agarwood complex, 170 parts sweet potato gum polymer adhesive, 55 parts thymol, 40 parts costunolide, 18 parts polyacrylamide, 38 parts ethyl acetate, 28 parts polyethylene glycol monomethyl ether methacrylate, 85 parts casein phosphopeptide, 115 parts anhydrous ethanol, and 125 parts ultrapure water.

[0033] The preparation method of the agarwood complex specifically includes the following steps: S1. Weigh 280 parts by weight of agarwood and 115 parts by weight of styrax. Use a drying oven with a power of 2.9 kW, a drying temperature of 118℃, and a drying time of 37 min. After drying, put them into a pulverizer with a power of 1.4 kW, a pulverizing temperature of 28℃, a pulverizing time of 24 min, and a pulverizing speed of 1800 r / min. After pulverizing, obtain wood pulverizer. S2. Weigh 29 parts by weight of sodium sulfite, mix with 175 parts of ultrapure water, put into a 1.5 kW mixer, stir at 55℃ for 14 min, stir at 170 r / min to obtain sodium sulfite solution. S3. Place the wood pulverizer from S1 into the sodium sulfite solution prepared in S2, stir at 34°C for 19 min, and at 330 r / min to mix and obtain the pulverized mixture. S4. Weigh out 85 parts by weight of cattail pollen, 75 parts by weight of dried tangerine peel, and 64 parts by weight of turmeric. Place them in a drying oven with a power of 2.9 kW, dry at 68℃ for 24 min. After drying, place them in a grinder with a power of 1.4 kW for 28 min, grind at 23℃, and grind at 2100 r / min. After grinding, mix them with 340 parts by weight of sweet almond oil in a mixer with a power of 1.5 kW, mix at 39℃ for 24 min, and mix at 120 r / min. Mix well and soak at a constant temperature for 3.8 h to obtain active aromatic oil. S5. The pulverized mixture prepared in S3 and the active aromatic oil prepared in S4 are placed in a 1.9 kW grinding mill. The grinding temperature is 64℃, the grinding time is 28 min, and the grinding speed is 1700 r / min. After grinding, the agarwood complex is obtained.

[0034] The preparation method of the sweet potato gum polymer adhesive specifically includes the following steps: L1. Weigh 128 parts by weight of sweet potato gum and dissolve it in 225 parts by weight of ultrapure water to form a matrix gum solution. L2. Weigh 75 parts by weight of vinyl acetate resin, 52 parts by weight of hydroquinone, 37 parts by weight of polymethyl methacrylate and 210 parts by weight of anhydrous ethanol, and place them in a constant temperature stirring pot with a power of 2.3 kW. The stirring temperature is 68℃, the stirring time is 18 min, and the stirring speed is 170 r / min. Polymerization occurs during heating and stirring. Then, the mixture is placed in a spray dryer with a power of 3.1 kW. The spray drying temperature is 128℃, the spray drying time is 28 s, and the spray dried particle size is 7 mm. The polymer particles are obtained by spray drying. L3. The polymer particles prepared by L2 and the matrix adhesive solution prepared by L1 were placed in a stirring and heating pot with a power of 1.7 kW. The stirring and heating temperature was 59℃, the stirring and heating time was 23 min, and the stirring and heating speed was 150 r / min. After stirring and mixing, the mixture was kept at the temperature for 2.8 h to obtain the sweet potato gum polymer adhesive.

[0035] This embodiment also proposes a method for preparing a novel agarwood moxibustion for promoting blood circulation, relieving depression, and removing blood stasis, which specifically includes the following steps: Step 1: Place the agarwood complex and sweet potato gum polymer binder into a 1.5 kW mixer, mix at 32°C for 28 min at 250 r / min, and mix until homogeneous to obtain a mixture. Step 2: Place the mixture of contents prepared in Step 1 into a pressure molding machine with a power of 11 kW, press the molding pressure at 1.7 kN, press the molding temperature at 107℃, press the molding time at 32 min, press the molding length at 25 cm, press the molding diameter at 2.1 cm, and obtain a cylindrical agarwood moxa stick after pressing. Step 3: Place thymol, costunol, polyacrylamide, ethyl acetate, and anhydrous ethanol into a 1.5kW mixer, stir at 29℃ for 14 min, and at 210 r / min to obtain an antioxidant stabilizer. Step 4: Place polyethylene glycol monomethyl ether methacrylate, casein phosphopeptide, and ultrapure water into a 1.5 kW mixer, mix at 31°C for 15 min at 175 r / min to obtain a film-forming agent. Step 5: Add the film preparation agent made in Step 4 to the antioxidant stabilizer prepared in Step 3. Stir at 34°C for 25 minutes and at 220 r / min until homogeneous to obtain the antioxidant stabilizing coating solution. Step 6: Place the cylindrical agarwood moxibustion prepared in Step 2 into the antioxidant and stabilizing coating solution prepared in Step 5. The soaking temperature is 31℃ and the soaking time is 18 seconds. After soaking, take it out and place it in a constant temperature drying oven with a power of 1.7 kW. The constant temperature drying temperature is 72℃ and the constant temperature drying time is 10 minutes to obtain a new type of agarwood moxibustion that promotes blood circulation, relieves depression and removes blood stasis.

[0036] Experimental Example 1: Test on the effects of promoting blood circulation, removing blood stasis, and relieving depression in mice.

[0037] The novel agarwood moxibustion for promoting blood circulation, relieving depression, and removing blood stasis prepared in Examples 1-5 of this invention has the following experimental steps for determining its effects: (1) Sixty NH mice, females 8 weeks old, each weighing 20 g (purchased from the Laboratory of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing, and the Henan Cancer Institute), were selected and randomly divided into 6 groups of 10 mice each. 37 Sarcoma cells at 5×10 5 One cell / mouse was inoculated intradermally on the outer side of the right hind limb of NH mice and fed for 5 days to obtain tumor-bearing mouse models; (2) The experimental group mice were treated with the novel agarwood moxibustion prepared in Examples 1-5 to promote blood circulation, relieve depression and remove blood stasis. After being heated by microwave, the moxibustion was applied to the right hind limb of the mice for 20 minutes. The moxibustion was applied for 3 consecutive days, once a day. Ordinary agarwood moxibustion was used as the control group. Ordinary agarwood moxibustion was lit and used to fumigate the right hind limb of the mice for 20 minutes. The control group mice were fumigated for 3 consecutive days, once a day. (3) After the 3rd day, the mice were decapitated and blood was collected to measure the whole blood viscosity and erythrocyte electrophoresis time. (4) Take 5 mL of blood from the aorta of the mouse abdomen, let it stand for 30 min, centrifuge at 3500 r / min for 15 min, separate the serum, and use the mouse 5-hydroxytryptamine kit (purchased from ELISA, catalog number: YJ32569) and mouse norepinephrine kit (purchased from ELISA, catalog number: YJ11269) to determine the content of 5-hydroxytryptamine and norepinephrine in the mouse.

[0038] Experimental Example 2: Guinea Pig Skin Irritation Test.

[0039] The novel agarwood moxibustion prepared according to Examples 1-5 of this invention for promoting blood circulation, relieving depression, and removing blood stasis, has the following skin irritation test steps on white guinea pigs: (1) Select 60 healthy white male guinea pigs weighing 700 g each, and randomly divide them into 6 groups of 10 each; (2) Routine hair removal was performed on both sides of the back of the white guinea pig. The hair removal area was 3cm×3cm. After 24 hours of hair removal, the local skin was observed to be intact and without damage. The experiment used the same guinea pig to compare the left and right sides. The experimental groups 1-5 applied the heated moxibustion prepared by Example 1-5 to the left side of the back of the guinea pig. The moxibustion was applied once a day for 20 minutes each time. The control group guinea pig was treated with ordinary moxibustion that was lit and fumigated once a day for 20 minutes each time. After 3 days of continuous use, the treated area was cleaned with warm water and observed. (3) After cleaning with warm water, observe and record the presence of erythema and edema on the left side of the back of the guinea pig at 24, 48 and 72 h. Calculate the average score of each group of guinea pigs at each observation time point according to Table 1. Evaluate the intensity of stimulation according to Table 2.

[0040] Table 1. Skin Irritation Response Scoring Criteria

[0041] Table 2. Evaluation Criteria for Skin Irritation Intensity

[0042] Table 3. Results of Skin Irritation Reactions

[0043] Results analysis: As shown in Table 3, the physiological structure of guinea pig skin is similar to that of human skin. No erythema or edema appeared on the back of the white guinea pigs in Examples 1-5, while the white guinea pigs in the control group showed moderate irritation on the back. This indicates that the novel agarwood moxibustion for promoting blood circulation, relieving depression and removing blood stasis prepared in this invention has excellent biocompatibility and is non-toxic and non-irritating to the skin.

[0044] Experiment Example 3: Determination of Storage Conditions of Agarwood Moxibustion.

[0045] The novel agarwood moxibustion for promoting blood circulation, relieving depression, and removing blood stasis prepared in Examples 1-5 of this invention has the following storage conditions determination test steps: (1) Take 10 g each of the novel agarwood moxibustion for relieving depression and removing blood stasis prepared in Examples 1-5 and the ordinary agarwood moxibustion for the control group, and take three parallel samples for each group; (2) The novel agarwood moxibustion for relieving depression and removing blood stasis prepared in Examples 1-5 and the ordinary agarwood moxibustion of the control group were stored at temperatures of 25°C and 37°C, respectively. (3) Under the temperature conditions of 25℃ and 37℃, 1 g of the novel agarwood moxibustion for relieving depression and removing blood stasis prepared in Examples 1-5 and the ordinary agarwood moxibustion of the control group were taken respectively. Three parallel samples were taken from each group. The number of bacteria in the samples was measured every 5 days for 40 consecutive days. (4) The novel agarwood moxibustion for relieving depression and removing blood stasis prepared in Examples 1-5 and the ordinary agarwood moxibustion of the control group were placed in test tubes containing 10 mL of sterile liquid LB medium and cultured in a shaker at 37℃ and 120 r / min for 24 h to obtain the cultured bacterial solution. (5) Dilute the cultured bacterial solution 100 times, spread it evenly on LB solid medium plates in a clean bench, and invert it in a 37℃ constant temperature incubator for 24 h to obtain the number of colonies in the experimental group. Calculate the number of colonies according to the formula: Total number of colonies (cfu / g) = Number of colonies on each plate × Dilution factor.

[0046] Results analysis: Figure 1The figure shows the results of whole blood viscosity measurement in mice as described in Experiment 1 of this invention. As shown in the figure, after continuous pounding and application of the novel agarwood moxibustion described in Examples 1-5 to tumor-bearing model mice for 3 days, the whole blood viscosity of the mice was 6.45 mp / s, 6.16 mp / s, 5.79 mp / s, 5.92 mp / s, and 6.2 mp / s, respectively. In contrast, the whole blood viscosity of the control group mice after being treated with ordinary agarwood moxibustion was 9.24 mp / s. Figure 2 The figure shows the results of the erythrocyte electrophoresis time measurement of mice described in Experiment 1 of this invention. As shown in the figure, after continuous pounding and application of the novel agarwood moxibustion for relieving depression and removing blood stasis in Examples 1-5 to tumor-bearing model mice for 3 days, the erythrocyte electrophoresis time of the mice was 13.54 s, 13.3 s, 13.17 s, 13.5 s, and 13.26 s, while the erythrocyte electrophoresis time of the control group mice after ordinary agarwood moxibustion was 17.16 s. Figure 3 The figure shows the results of the determination of 5-hydroxytryptamine content in mice as described in Experiment 1 of this invention. As shown in the figure, after continuous pounding and application of the novel agarwood moxibustion for relieving depression and removing blood stasis in Examples 1-5 to tumor-bearing model mice for 3 days, the 5-hydroxytryptamine content in the mice was 3.39 ng / L, 3.57 ng / L, 3.79 ng / L, 3.66 ng / L, and 3.45 ng / L, respectively. In contrast, after ordinary agarwood moxibustion, the 5-hydroxytryptamine content in the control group mice was 2.51 ng / L. Figure 4 The figure shows the results of norepinephrine content determination in mice as described in Experiment 1 of this invention. As shown in the figure, after continuous pounding and application of the novel agarwood moxibustion for relieving depression and removing blood stasis in Examples 1-5 to tumor-bearing model mice for 3 days, the norepinephrine content in the mice was 1.11 ng / g, 1.15 ng / g, 1.17 ng / g, 1.13 ng / g, and 1.15 ng / g, respectively. In contrast, the norepinephrine content in the control group mice after ordinary agarwood moxibustion was 0.76 ng / g. This indicates that the novel agarwood moxibustion for relieving depression and removing blood stasis prepared in this invention can be used without combustion, does not produce irritating smoke, has a rapid onset of action, and effectively unblocks meridians, promotes blood circulation, removes blood stasis, and regulates the occurrence of depressive mood.

[0047] Figure 5 The figure shows the results of the total bacterial count determination at 25°C as described in Experimental Example 3 of this invention. As shown in the figure, the novel agarwood moxibustion for relieving depression and removing blood stasis described in Examples 1-5, after being stored at 25°C for 40 days, contained total bacterial counts of 9.4 CFU / g, 8.3 CFU / g, 6.5 CFU / g, 8.5 CFU / g, and 7.2 CFU / g, respectively, while the total bacterial count of the control group ordinary agarwood moxibustion was 105.6 CFU / g. Figure 6The figure shows the results of the total bacterial count determination at 37℃ in Experimental Example 3 of this invention. As shown in the figure, the novel agarwood moxibustion for relieving depression and removing blood stasis described in Examples 1-5, after being stored at 37℃ for 40 days, had total bacterial counts of 11.2 cfu / g, 9.6 cfu / g, 7.2 cfu / g, 8.7 cfu / g, and 7.8 cfu / g, respectively. In contrast, the total bacterial count of the ordinary agarwood moxibustion in the control group was 114.8 cfu / g. This indicates that the novel agarwood moxibustion for relieving depression and removing blood stasis prepared by this invention is easy to store, will not mold or deteriorate during long-term storage, and does not have any harmful effects on the body's health.

[0048] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

[0049] The present invention and its embodiments have been described above. This description is not restrictive, and the accompanying drawings are only one embodiment of the present invention. The actual application is not limited to this. In conclusion, if those skilled in the art are inspired by this description and design similar methods and embodiments without departing from the spirit of the present invention, they should all fall within the protection scope of the present invention.

Claims

1. A novel agarwood moxibustion method for promoting blood circulation, relieving depression, and removing blood stasis, characterized in that... The novel agarwood moxibustion for promoting blood circulation, relieving depression, and removing blood stasis specifically comprises the following components by weight: The composition includes: 280-320 parts agarwood complex, 130-180 parts sweet potato gum polymer adhesive, 30-60 parts thymol, 25-45 parts costunolide, 10-20 parts polyacrylamide, 30-40 parts ethyl acetate, 20-30 parts polyethylene glycol monomethyl ether methacrylate, 70-90 parts casein phosphopeptide, 100-120 parts anhydrous ethanol, and 110-130 parts ultrapure water.

2. The novel agarwood moxibustion for promoting blood circulation, relieving stagnation, and removing blood stasis according to claim 1, characterized in that, The preparation method of the agarwood complex specifically includes the following steps: Agarwood complex is prepared by drying and pulverizing 200-300 parts by weight of agarwood and 100-120 parts by weight of styrax, mixing and softening them with sodium sulfite solution, and then adding active aromatic oil and grinding.

3. The novel agarwood moxibustion for promoting blood circulation, relieving stagnation, and removing blood stasis according to claim 2, characterized in that, The method for preparing the sodium sulfite solution specifically includes the following steps: Mix 25-30 parts by weight of sodium sulfite with 150-180 parts of ultrapure water and stir until homogeneous to obtain a sodium sulfite solution. The preparation method of the active aromatic oil specifically includes the following steps: The active aromatic oil is obtained by drying and grinding 70-90 parts by weight of cattail pollen, 50-80 parts by weight of dried tangerine peel, and 60-65 parts by weight of turmeric into powder, then mixing it with 300-350 parts by weight of sweet almond oil and soaking it at a constant temperature.

4. The novel agarwood moxibustion for promoting blood circulation, relieving stagnation, and removing blood stasis according to claim 1, characterized in that, The preparation method of the sweet potato gum polymer adhesive specifically includes the following steps: Dissolve 115-130 parts by weight of sweet potato gum in 200-230 parts by weight of ultrapure water to form a matrix gum solution, stir and mix it with polymer particles, and heat to modify it to obtain sweet potato gum polymer adhesive.

5. The novel agarwood moxibustion for promoting blood circulation, relieving stagnation, and removing blood stasis according to claim 4, characterized in that, The method for preparing the polymer particles specifically includes the following steps: 60-80 parts by weight of vinyl acetate resin, 40-55 parts by weight of hydroquinone, and 30-38 parts by weight of polymethyl methacrylate are dispersed in 180-220 parts by weight of anhydrous ethanol, and polymerized by heating and stirring. The polymer particles are obtained by spray drying.

6. A method for preparing a novel agarwood moxibustion for promoting blood circulation, relieving stagnation, and removing blood stasis according to any one of claims 1-5, characterized in that, Specifically, the steps include the following: Step 1: Mix the agarwood complex with the sweet potato gum polymer binder evenly and then press it into shape to obtain cylindrical agarwood moxa sticks. Step 2: Mix thymol, costunol, polyacrylamide, ethyl acetate, and anhydrous ethanol to obtain an antioxidant stabilizer. Step 3: Mix polyethylene glycol monomethyl ether methacrylate, casein phosphopeptide, and ultrapure water until homogeneous to obtain a film-forming agent; Step 4: Add the film-forming agent prepared in Step 3 to the antioxidant stabilizer prepared in Step 2, stir evenly, and obtain the antioxidant stabilizing coating solution; Step 5: Place the cylindrical agarwood moxibustion prepared in Step 1 into the antioxidant and stabilizing coating solution prepared in Step 4, soak it, take it out, and dry it at a constant temperature to obtain a new type of agarwood moxibustion that promotes blood circulation, relieves depression, and removes blood stasis.

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