A traditional Chinese medicine composition of a golden cicada kidney-tonifying prescription effective against kidney damage caused by drug toxicity and acute and chronic interstitial nephritis and applications thereof

Abstract

The application belongs to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine composition of a kidney-reinforcing prescription of Jinchan for effectively treating kidney damage caused by drug toxicity and acute and chronic interstitial nephritis and application thereof, which is prepared from raw materials in the following mass fractions: 5-45 parts of raw astragalus, 10-20 parts of Szechwan lovage rhizome, 10-30 parts of kudzu root, 10-30 parts of yellow dock, 10-30 parts of cicada flower, 10-20 parts of curcuma zedoary, 10-20 parts of soft-shelled turtle egg, 5-15 parts of safflower, 15-30 parts of spatholobi stem, 10 parts of red peony root, and 15-30 parts of red ginseng. The traditional Chinese medicine composition is prepared from pure traditional Chinese medicines, has a wide drug source, high safety, and no side effects compared with traditional western medicines. The drugs are used in combination and have a synergistic effect, have the effects of tonifying liver and kidney, detoxicating and detumescing, and clearing heat and diuresis, and can enhance the human mechanism, greatly improve the patient's symptoms in two weeks to one month of treatment, and have obvious effects and clear indicators.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and in particular to a traditional Chinese medicine composition and its application of the Jinchan Bushen Formula, which is effective in treating kidney damage and acute and chronic interstitial nephritis caused by drug toxicity. Background Technology

[0002] Drug-induced kidney injury is a common adverse reaction in clinical practice, especially with long-term use of certain Western medicines, such as gentamicin and tripterygium wilfordii, which can easily lead to nephrotoxicity, causing acute or chronic kidney damage, and in severe cases, kidney failure. Acute and chronic interstitial nephritis are also common kidney diseases with complex etiologies and difficult treatment. Currently, neither traditional Chinese medicine nor Western medicine has effective treatments for these diseases. Therefore, developing a safe, effective, and low-side-effect traditional Chinese medicine composition is of great significance.

[0003] Professor Chen Yiping is a pioneer of integrated traditional Chinese and Western medicine in treating nephrology. He served as the chairman of the National Association of Integrated Traditional Chinese and Western Medicine for Nephrology for two terms and was a member of the National Committee of Renowned Veteran Traditional Chinese Medicine Practitioners. The formula provided by Professor Chen Yiping is the only clearly effective treatment method, and its clinical practice over the past ten years has yielded remarkable results. Summary of the Invention

[0004] The purpose of this invention is to provide a traditional Chinese medicine composition and its application for Jinchan Bushen Formula, which is effective in treating kidney damage and acute and chronic interstitial nephritis caused by drug toxicity, in order to overcome the defects existing in the prior art.

[0005] To achieve the above-mentioned objectives, the present invention provides the following technical solution:

[0006] This invention provides a traditional Chinese medicine composition for Jinchan Bushen Formula, which is effective in treating kidney damage and acute and chronic interstitial nephritis caused by drug toxicity. It is prepared from raw materials comprising the following parts by weight:

[0007] Raw Astragalus 5-45 parts, Ligusticum chuanxiong 10-20 parts, Pueraria lobata 10-30 parts, Polygonatum sibiricum 10-30 parts, Cornus officinalis 10-30 parts, Cicadae periostracum 10-30 parts, Curcuma zedoaria 10-20 parts, Mantis egg case 10-20 parts, Carthamus tinctorius 5-15 parts, Spatholobus suberectus 15-30 parts, Paeonia lactiflora 10 parts, Rhodiola rosea 15-30 parts.

[0008] Preferably, the traditional Chinese medicine composition is prepared from raw materials comprising the following parts by weight:

[0009] Raw Astragalus membranaceus 10-40 parts, Ligusticum chuanxiong 12-18 parts, Pueraria lobata 12-28 parts, Polygonatum sibiricum 12-28 parts, Cornus officinalis 12-28 parts, Cicadae periostracum 12-28 parts, Curcuma zedoaria 12-18 parts, Mantis religiosa ootheca 12-18 parts, Carthamus tinctorius 6-14 parts, Spatholobus suberectus 17-28 parts, Paeonia lactiflora 10 parts, Rhodiola rosea 17-28 parts.

[0010] Preferably, the traditional Chinese medicine composition is prepared from raw materials comprising the following parts by weight:

[0011] Astragalus membranaceus 25 parts, Ligusticum chuanxiong 15 parts, Pueraria lobata 20 parts, Polygonatum sibiricum 20 parts, Cornus officinalis 20 parts, Cicadae periostracum 20 parts, Curcuma zedoaria 15 parts, Mantis egg case 15 parts, Carthamus tinctorius 10 parts, Spatholobus suberectus 22 parts, Paeonia lactiflora 10 parts, Rhodiola rosea 22 parts.

[0012] The present invention also provides the application of the aforementioned traditional Chinese medicine composition in the treatment of drug-induced kidney damage and acute and chronic interstitial nephritis.

[0013] The present invention has the following beneficial effects:

[0014] The traditional Chinese medicine composition provided by this invention is prepared using pure Chinese herbs, with abundant medicinal resources and high safety, and has no side effects compared to traditional Western medicine. The combined effects of these herbs are synergistic, possessing the functions of tonifying the liver and kidneys, detoxifying and reducing swelling, clearing heat and promoting diuresis. Simultaneously, it enhances the body's mechanisms, significantly improving patients' symptoms within two weeks to one month of treatment, with clear and obvious efficacy indicators. Attached Figure Description

[0015] Figure 1 The graph shows the change in SCR concentration after patient C of the present invention takes the traditional Chinese medicine composition of Example 3. Detailed Implementation

[0016] This invention provides a traditional Chinese medicine composition for Jinchan Bushen Formula, which is effective in treating kidney damage and acute and chronic interstitial nephritis caused by drug toxicity. It is prepared from raw materials comprising the following parts by weight:

[0017] Raw Astragalus 5-45 parts, Ligusticum chuanxiong 10-20 parts, Pueraria lobata 10-30 parts, Polygonatum sibiricum 10-30 parts, Cornus officinalis 10-30 parts, Cicadae periostracum 10-30 parts, Curcuma zedoaria 10-20 parts, Mantis egg case 10-20 parts, Carthamus tinctorius 5-15 parts, Spatholobus suberectus 15-30 parts, Paeonia lactiflora 10 parts, Rhodiola rosea 15-30 parts.

[0018] In this invention, the mass fraction of the raw Astragalus membranaceus is preferably 10 to 40 parts, more preferably 15 to 35 parts, and even more preferably 20 to 30 parts.

[0019] In this invention, the mass fraction of the Ligusticum striatum is preferably 12 to 18 parts, more preferably 13 to 17 parts, and even more preferably 14 to 16 parts.

[0020] In this invention, the mass fraction of the kudzu root is preferably 12 to 28 parts, more preferably 14 to 26 parts, and even more preferably 16 to 24 parts.

[0021] In this invention, the mass fraction of the Polygonatum is preferably 12 to 28 parts, more preferably 14 to 26 parts, and even more preferably 16 to 24 parts.

[0022] In this invention, the mass fraction of the Cornus officinalis is preferably 12 to 28 parts, more preferably 14 to 26 parts, and even more preferably 16 to 24 parts.

[0023] In this invention, the mass fraction of the cicada flower is preferably 12 to 28 parts, more preferably 14 to 26 parts, and even more preferably 16 to 24 parts.

[0024] In this invention, the mass fraction of the turmeric is preferably 12 to 18 parts, more preferably 13 to 17 parts, and even more preferably 14 to 16 parts.

[0025] In this invention, the mass fraction of the mantis egg case is preferably 12 to 18 parts, more preferably 13 to 17 parts, and even more preferably 14 to 16 parts.

[0026] In this invention, the safflower is preferably 6 to 14 parts by weight, more preferably 7 to 13 parts, and even more preferably 8 to 12 parts by weight.

[0027] In this invention, the mass fraction of the chicken blood vine is preferably 17 to 28 parts, more preferably 19 to 26 parts, and even more preferably 21 to 24 parts.

[0028] In this invention, the preferred mass fraction of the red peony root is 10 parts.

[0029] In this invention, the mass fraction of Rhodiola rosea is preferably 17 to 28 parts, more preferably 19 to 26 parts, and even more preferably 21 to 24 parts.

[0030] In this invention, the traditional Chinese medicine composition needs to be decocted before consumption.

[0031] This invention also provides the application of the aforementioned traditional Chinese medicine composition in treating drug-induced kidney damage and acute and chronic interstitial nephritis.

[0032] The technical solutions provided by the present invention will be described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention.

[0033] Example 1

[0034] Weigh out 25g of raw Astragalus membranaceus, 15g of Ligusticum chuanxiong, 20g of Pueraria lobata, 20g of Polygonatum sibiricum, 20g of Cornus officinalis, 20g of Cicadae periostracum, 15g of Curcuma zedoaria, 15g of Mantis religiosa ootheca, 10g of Carthamus tinctorius, 22g of Spatholobus suberectus, 10g of Paeonia lactiflora, and 22g of Rhodiola rosea, and decoct using conventional methods.

[0035] Example 2

[0036] Weigh out 5g of raw Astragalus membranaceus, 10g of Ligusticum chuanxiong, 10g of Pueraria lobata, 10g of Polygonatum sibiricum, 10g of Cornus officinalis, 10g of Cicadae periostracum, 10g of Curcuma zedoaria, 10g of Mantis religiosa ootheca, 5g of Carthamus tinctorius, 15g of Spatholobus suberectus, 10g of Paeonia lactiflora, and 15g of Rhodiola rosea, and decoct using conventional methods.

[0037] Example 3

[0038] Weigh out 10g of raw Astragalus membranaceus, 12g of Ligusticum chuanxiong, 12g of Pueraria lobata, 12g of Polygonatum sibiricum, 12g of Cornus officinalis, 12g of Cicadae periostracum, 12g of Curcuma zedoaria, 12g of Mantis religiosa ootheca, 6g of Carthamus tinctorius, 17g of Spatholobus suberectus, 10g of Paeonia lactiflora, and 17g of Rhodiola rosea, and decoct using conventional methods.

[0039] Example 4

[0040] Weigh out 40g of raw Astragalus membranaceus, 18g of Ligusticum chuanxiong, 28g of Pueraria lobata, 28g of Polygonatum sibiricum, 28g of Cornus officinalis, 28g of Cicadae periostracum, 18g of Curcuma zedoaria, 18g of Mantis religiosa ootheca, 14g of Carthamus tinctorius, 28g of Spatholobus suberectus, 10g of Paeonia lactiflora, and 28g of Rhodiola rosea, and decoct using conventional methods.

[0041] Example 5

[0042] Weigh out 45g of raw Astragalus membranaceus, 20g of Ligusticum chuanxiong, 30g of Pueraria lobata, 30g of Polygonatum sibiricum, 30g of Cornus officinalis, 30g of Cicadae periostracum, 20g of Curcuma zedoaria, 20g of Mantis religiosa ootheca, 15g of Carthamus tinctorius, 30g of Spatholobus suberectus, 10g of Paeonia lactiflora, and 30g of Rhodiola rosea, and decoct using conventional methods.

[0043] Example 6

[0044] Weigh out 35g of raw Astragalus membranaceus, 16g of Ligusticum chuanxiong, 22g of Pueraria lobata, 22g of Polygonatum sibiricum, 25g of Cornus officinalis, 25g of Cicadae periostracum, 16g of Curcuma zedoaria, 16g of Mantis religiosa ootheca, 9g of Carthamus tinctorius, 20g of Spatholobus suberectus, 10g of Paeonia lactiflora, and 20g of Rhodiola rosea, and decoct using conventional methods.

[0045] Effect test:

[0046] Patient A underwent four CTA tests, which initially diagnosed renal dysfunction. In July 2024, due to chest pain, an abnormal myocardial enzyme spectrum was found, and the concentrations of Scr (serum creatinine) were 113 μmol / L, UA (serum uric acid) were 490 μmol / L, and K (urine potassium) were 5.2 mmol / 24H. At the time of consultation, the patient presented with two loose bowel movements per day, with no other discomfort, and a pale red tongue with a thin, greasy coating.

[0047] The herbal composition obtained in Example 1 was subsequently administered to the patient twice daily. A follow-up examination three months later showed improved renal function, as follows: hemoglobin concentration was 139 g / L, hematocrit was 42.6%, total protein concentration was 76.1 g / L, albumin concentration was 45.3 g / L, prealbumin concentration was 0.28 g / L, globulin concentration was 30.8 g / L, alanine aminotransferase concentration was 19 U / L, aspartate aminotransferase concentration was 21 U / L, AST / ALT ratio was 1.11, gamma-glutamyl transferase concentration was 14 U / L, creatinine concentration was 79.7 μmol / L, urea concentration was 6.57 mmol / L, uric acid concentration was 187 μmol / L, and 24-hour urinary protein concentration was 70 mg / 24H.

[0048] It is evident that the renal function indicators of patient A, who used the traditional Chinese medicine composition of this application, were greatly improved.

[0049] Patient B had a history of recurrent proteinuria for over 20 years. Around age 15, they sought medical attention for proteinuria and subsequently took the traditional Chinese medicine composition provided in this application for over 10 years, resulting in stable renal function and negative proteinuria. Later, due to asthma, they took traditional Chinese medicine from another hospital for 7 years, reporting that the formula contained Aristolochia manshuriensis. In recent years, they underwent three enhanced CT scans, showing a serum creatinine (Scr) concentration of 110 μmol / L, a urine protein level of 0.3 mg / 24H, and a positive urine retinol protein level. They continued taking the traditional Chinese medicine composition from this application, and two months later, a follow-up examination showed a Scr concentration of 68 μmol / L, an eGFR (glomerular filtration rate) of 114.7 ml / min, and negative urine retinol protein.

[0050] Patient C first visited on January 9, 2024. The patient had a history of malignant tumor and had received trametinib targeted therapy at another hospital. Before treatment, renal function was normal (Scr concentration was 71 μmol / L). After treatment, the Scr concentration rose to 217.3 μmol / L, and the targeted therapy was temporarily suspended before visiting our hospital. The patient then took the traditional Chinese medicine composition obtained in Example 3 of this application twice a day, and received integrated treatment for renal failure. The patient's Scr decreased and returned to normal on February 9, 2024. The patient then took the traditional Chinese medicine composition at a reduced dosage until the follow-up on May 2024, when the Scr concentration was 78.6 μmol / L.

[0051] This patient had no prior history of chronic kidney disease. After taking targeted drugs and large doses of painkillers, renal function declined. Upon admission, pre- and post-renal factors were ruled out, and the diagnosis was confirmed as "drug-induced kidney damage." Subsequent use of the traditional Chinese medicine composition formulated in this application, combined with Shenkang and Atorvastatin, significantly improved renal function. After more than one month of medication, renal function recovered and stabilized. Figure 1 As shown.

[0052] from Figure 1As can be seen from the above, the traditional Chinese medicine composition formulated in this application has a significant therapeutic effect on kidney damage caused by drug toxicity, and the patient's kidney function is significantly improved and restored, with no other adverse reactions.

[0053] As can be seen from the above embodiments, the present invention provides a traditional Chinese medicine composition and its application for Jinchan Bushen Formula, which is effective in treating kidney damage and acute and chronic interstitial nephritis caused by drug toxicity. It is prepared from raw materials comprising the following parts by weight: 5-45 parts of raw Astragalus membranaceus, 10-20 parts of Ligusticum chuanxiong, 10-30 parts of Pueraria lobata, 10-30 parts of Polygonatum sibiricum, 10-30 parts of Cornus officinalis, 10-30 parts of Cicadae periostracum, 10-20 parts of Curcuma zedoaria, 10-20 parts of Mantis religiosa ootheca, 5-15 parts of Carthamus tinctorius, 15-30 parts of Spatholobus suberectus, 10 parts of Paeonia lactiflora, and 15-30 parts of Rhodiola rosea. The traditional Chinese medicine composition provided by the present invention is prepared using pure traditional Chinese medicine, with a wide range of medicinal sources, high safety, and no side effects compared to traditional Western medicine. The combined use of these herbs has a synergistic effect, possessing the functions of tonifying the liver and kidneys, detoxifying and reducing swelling, clearing heat and promoting diuresis, while simultaneously enhancing the body's mechanisms. It can significantly improve patients' symptoms within two weeks to one month of treatment, with obvious and clear efficacy indicators.

[0054] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A traditional Chinese medicine composition based on a cicada-based kidney-tonifying formula that is effective against drug-induced kidney damage and acute / chronic interstitial nephritis, characterized in that... Prepared from raw materials comprising the following parts by mass: Raw Astragalus 5-45 parts, Ligusticum chuanxiong 10-20 parts, Pueraria lobata 10-30 parts, Polygonatum sibiricum 10-30 parts, Cornus officinalis 10-30 parts, Cicadae periostracum 10-30 parts, Curcuma zedoaria 10-20 parts, Mantis egg case 10-20 parts, Carthamus tinctorius 5-15 parts, Spatholobus suberectus 15-30 parts, Paeonia lactiflora 10 parts, Rhodiola rosea 15-30 parts.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, Prepared from raw materials comprising the following parts by mass: Raw Astragalus membranaceus 10-40 parts, Ligusticum chuanxiong 12-18 parts, Pueraria lobata 12-28 parts, Polygonatum sibiricum 12-28 parts, Cornus officinalis 12-28 parts, Cicadae periostracum 12-28 parts, Curcuma zedoaria 12-18 parts, Mantis religiosa ootheca 12-18 parts, Carthamus tinctorius 6-14 parts, Spatholobus suberectus 17-28 parts, Paeonia lactiflora 10 parts, Rhodiola rosea 17-28 parts.

3. The traditional Chinese medicine composition according to claim 1, characterized in that, Prepared from raw materials comprising the following parts by mass: Astragalus membranaceus 25 parts, Ligusticum chuanxiong 15 parts, Pueraria lobata 20 parts, Polygonatum sibiricum 20 parts, Cornus officinalis 20 parts, Cicadae periostracum 20 parts, Curcuma zedoaria 15 parts, Mantis egg case 15 parts, Carthamus tinctorius 10 parts, Spatholobus suberectus 22 parts, Paeonia lactiflora 10 parts, Rhodiola rosea 22 parts.

4. The use of the traditional Chinese medicine composition according to any one of claims 1 to 3 in treating drug-induced kidney damage and acute and chronic interstitial nephritis.

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