An electric stimulation synergizes with hyperbaric oxygen to promote burn healing system and its manufacturing method

Abstract

The application discloses a system for promoting burn healing by synergistic effect of electric stimulation and hyperbaric oxygen and a manufacturing method thereof, which comprises an electric stimulation module and a hyperbaric oxygen module for respectively providing electric stimulation and hyperbaric oxygen supply to a burn wound area, a conductive functional elastomer, a monitoring module and a control module; the electric stimulation module comprises a positive electrode and a negative electrode of an external electric stimulation device; the monitoring module comprises an air pressure sensor and a micro oxygen concentration sensor; the hyperbaric oxygen module comprises a hyperbaric oxygen bag; the positive electrode, the negative electrode, the air pressure sensor and the micro oxygen concentration sensor are all arranged at an air outlet of the hyperbaric oxygen bag and fixed through the functional elastomer, forming an integrated structure; the control module is used for receiving an air pressure value transmitted by the air pressure sensor and an oxygen concentration value transmitted by the micro oxygen concentration sensor in real time, and realizing synergistic regulation and control of electric stimulation parameters and hyperbaric oxygen parameters according to the air pressure value and the oxygen concentration value. The electric stimulation and the hyperbaric oxygen are beneficial to promoting the healing of the burn wound area.

Description

Technical Field

[0001] This invention relates to the field of burn healing promotion technology, and in particular to an electrical stimulation combined with hyperbaric oxygen therapy system for promoting burn healing and its manufacturing method. Background Technology

[0002] Burns, as a severe injury to the skin and tissues, have a complex and lengthy healing process, often accompanied by complications such as infection, severe pain, fluid loss, and functional impairment. Ideal burn treatment not only requires wound closure but also proactive intervention to accelerate the physiological healing process. Currently, various adjunctive treatments exist clinically, among which electrostimulation therapy and hyperbaric oxygen therapy have shown significant potential in promoting wound healing; however, each has its own technical limitations and application restrictions when used in burn treatment.

[0003] Current Status and Limitations of Electrostimulation Therapy: Electrostimulation therapy promotes healing by mimicking the endogenous electric field generated in human skin after injury and using external current to regulate cell behavior. However, the application of existing electrostimulation technologies in burn treatment still faces challenges. First, the endogenous electric field generated in burn wounds is much weaker than that of ordinary wounds, which slows down the healing process and places higher demands on the parameters and modes of exogenous electrical stimulation. Second, there is currently a lack of unified and standardized electrostimulation treatment protocols. Different studies use vastly different current types (such as pulsed current, microcurrent), intensities, frequencies, and treatment durations, leading to difficulties in clinical translation.

[0004] Current Status and Limitations of Hyperbaric Oxygen Therapy: Hyperbaric oxygen therapy refers to a treatment method in which patients inhale 100% pure oxygen in an environment with a pressure higher than one standard atmosphere. It supports wound healing from a systemic perspective by significantly increasing the oxygen partial pressure in the blood and tissues. Its mechanism for promoting burn healing includes:

[0005] Correcting tissue hypoxia: Providing sufficient oxygen to damaged ischemic and hypoxic tissues is fundamental to cell metabolism and tissue repair. Despite its significant effects, hyperbaric oxygen therapy has clear limitations. It is a systemic treatment, requiring patients to enter a large and expensive hyperbaric chamber, resulting in poor accessibility and making it difficult to implement in ordinary wards or homes. The treatment process requires continuous monitoring by professionals and equipment, incurring high costs. Furthermore, hyperbaric oxygen therapy is not without risks, potentially causing complications such as middle ear barotrauma, pulmonary barotrauma, and even oxygen toxicity-induced epilepsy, and places certain demands on the patient's physical condition.

[0006] In summary, electrostimulation therapy and hyperbaric oxygen therapy promote burn healing from two different dimensions: local cellular regulation and systemic support, respectively. However, these two therapies are currently completely separate in clinical practice. Patients need to receive two independent treatments, which not only increases the complexity and time cost of treatment but also fails to achieve synchronization and synergy between the two effects in time and space. Existing technology lacks an integrated system that can organically combine electrostimulation and hyperbaric oxygen therapy. Therefore, developing an electrostimulation-hyperbaric oxygen combined system for promoting burn healing is of significant clinical importance and application value for overcoming current treatment bottlenecks and achieving more efficient and convenient burn treatment. Summary of the Invention

[0007] This invention addresses the problems and shortcomings of existing technologies by providing an electrical stimulation-assisted hyperbaric oxygen therapy system for promoting burn healing and its manufacturing method.

[0008] The present invention solves the above-mentioned technical problems through the following technical solution:

[0009] This invention provides an electrical stimulation combined with hyperbaric oxygen therapy to promote burn healing system, characterized in that it includes an electrical stimulation module and a hyperbaric oxygen module that provide electrical stimulation and hyperbaric oxygen supply to the burn wound area respectively, a conductive functional elastomer, a monitoring module and a control module;

[0010] The electrostimulation module includes a positive electrode and a negative electrode of an external electrostimulation device. Both the positive and negative electrodes include a base layer at the bottom, an adhesive layer in the middle, and a conductive layer at the top. The positive electrode is formed by sequentially splicing together a large, open circular electrode, first straight electrodes at both ends of the large circular electrode, and first electrode plates at the ends of the two first straight electrodes. The negative electrode is placed inside the cavity of the positive electrode and does not contact the positive electrode. The negative electrode is formed by sequentially splicing together a small, closed circular electrode, a second straight electrode connected to the small circular electrode, and second electrode plates at the ends of the second straight electrode. The large circular electrode and the small circular electrode form a sensing area, and the first straight electrode and the second straight electrode form a lead channel.

[0011] The monitoring module includes a pressure sensor and a miniature oxygen concentration sensor. The sensing area contains the pressure sensor and the miniature oxygen concentration sensor, and the lead channel contains the wires of the pressure sensor and the miniature oxygen concentration sensor.

[0012] The high-pressure oxygen module includes a high-pressure oxygen bladder connected to an external high-pressure oxygen filling device. The positive electrode, negative electrode, pressure sensor, and miniature oxygen concentration sensor are all placed at the outlet of the high-pressure oxygen bladder and fixed by a conductive functional elastomer to form an integrated structure.

[0013] The control module is used to receive the air pressure value from the air pressure sensor and the oxygen concentration value from the micro oxygen concentration sensor in real time. Based on the air pressure value and oxygen concentration value, it realizes the coordinated regulation of the electrical stimulation parameters of the electrical stimulation device and the high-pressure oxygen parameters of the high-pressure oxygen filling device, so that the detected air pressure value is within the target air pressure value and the detected oxygen concentration value is within the target oxygen concentration value.

[0014] This invention also provides a method for manufacturing a system for promoting burn healing through electrical stimulation combined with hyperbaric oxygen therapy, characterized by comprising the following steps:

[0015] Step 1: Fabrication of the electrostimulation module: Design the structural drawings of the electrostimulation module in CAD software, input the structural drawings of the electrostimulation module into the ultraviolet laser engraving equipment, and achieve graphic cutting by laser etching of the area outside the graphic to manufacture the electrostimulation module;

[0016] The electrostimulation module structure includes a positive electrode and a negative electrode. Both the positive and negative electrodes include a base layer at the bottom, an adhesion layer in the middle, and a conductive layer at the top. The positive electrode is formed by sequentially splicing together a large, open circular electrode, first straight electrodes at both ends of the large circular electrode, and first electrode plates at the ends of the two first straight electrodes. The negative electrode is placed inside the cavity of the positive electrode and does not contact the positive electrode. The negative electrode is formed by sequentially splicing together a small, closed circular electrode, a second straight electrode connected to the small circular electrode, and second electrode plates at the ends of the second straight electrode. The large circular electrode and the small circular electrode form a sensing area, and the first straight electrode and the second straight electrode form a lead channel.

[0017] Step 2: Fabrication of a conductive functional elastomer: Fabrication of a conductive functional elastomer in the shape of a ring that matches the shape of the large ring electrode;

[0018] Step 3: Select the barometric pressure sensor and the miniature oxygen concentration sensor;

[0019] Step 4: The conductive functional elastomer wraps around the large circular electrode, the second linear electrode is fixed inside the conductive functional elastomer, the wires of the pressure sensor and the miniature oxygen concentration sensor are both fixed inside the conductive functional elastomer, and the pressure sensor and the miniature oxygen concentration sensor are placed in the sensing area, and the wires of the pressure sensor and the miniature oxygen concentration sensor are placed in the lead wire channel.

[0020] Step 5: Adhere the conductive functional elastomer installed in Step 4 around the outlet of the high-pressure oxygen bag. The small ring electrode, pressure sensor and micro oxygen concentration sensor are located at the outlet of the high-pressure oxygen bag, forming an integrated structure.

[0021] Step Six: Select a controller for the control module, connect the positive and negative electrodes to an external electrical stimulation device, connect the high-pressure oxygen bag to an external high-pressure oxygen filling device, and connect the wires of the pressure sensor and the miniature oxygen concentration sensor to the controller.

[0022] The positive and progressive effects of this invention are as follows:

[0023] The electrostimulation-assisted hyperbaric oxygen therapy system for promoting burn healing proposed in this invention integrates two complementary treatment methods into one, achieving synergistic therapy that produces significantly better technical effects than existing single-method or separate treatment approaches. Specifically, this is reflected in the following aspects:

[0024] 1. Achieving synergistic therapeutic effect: The core technical effect of this system is that it achieves a synergistic gain effect of 1+1>2, making the cells more sensitive and efficient in responding to electrical stimulation signals in an oxygen-rich environment, which is conducive to promoting the healing of burn wound areas.

[0025] Accelerated cell migration and proliferation: The hyperoxia environment created by hyperbaric oxygen significantly enhances the metabolic activity and energy (ATP) synthesis capacity of cells, which greatly enhances the directional migration speed and proliferation rate of keratinocytes and fibroblasts under electrical stimulation, thereby significantly shortening the re-epithelialization time.

[0026] Angiogenesis and tissue remodeling optimization: The synergistic effect of electrostimulation-induced vascular endothelial growth factor expression and hyperbaric oxygen-promoted angiogenesis can more effectively stimulate the formation of healthy granulation tissue. Simultaneously, the oxygen-rich environment facilitates the hydroxylation modification of collagen, making its structure more stable. Combined with the guiding effect of electrostimulation on collagen arrangement, this can significantly reduce scar formation and improve the mechanical strength and appearance quality of healing tissue.

[0027] 2. Overcoming the technical bottlenecks of single therapies: Through integrated design, this system effectively overcomes the technical limitations of existing electrical stimulation and hyperbaric oxygen therapy when applied independently.

[0028] Solving the energy hunger problem of electrical stimulation: Traditional electrical stimulation therapy has limited effectiveness in ischemic and hypoxic burn wounds because cells lack sufficient energy to respond to electric field signals. This system introduces hyperbaric oxygen support, which solves the energy hunger problem of cell repair from the source, enabling electrical stimulation therapy to play a more effective role in a wider range of burn depths and stages.

[0029] Improving the targeting and efficiency of hyperbaric oxygen therapy: Traditional hyperbaric oxygen therapy is a systemic, non-specific supportive treatment. This system uses local electrical stimulation as a targeted guide, focusing the superior physiological environment provided by hyperbaric oxygen on the electric field-guided repair pathway, thereby maximizing the resource utilization efficiency of systemic supportive treatment, avoiding resource waste, and reducing the risk of side effects (such as oxygen toxicity) that may be caused by prolonged systemic hyperbaric oxygen exposure.

[0030] 3. Provides an integrated and convenient treatment solution: This invention integrates two treatment functions into one system, bringing significant convenience to clinical applications.

[0031] Simplified treatment process: Patients no longer need to travel between different devices and departments to receive separate treatments, which greatly simplifies the treatment process and reduces the pain and inconvenience for patients.

[0032] Coordinated optimization of treatment parameters: The control module can coordinate the regulation of electrical stimulation parameters (such as current intensity, frequency, and waveform) and hyperbaric oxygen parameters (such as oxygen concentration and pressure). This integrated control can automatically or manually switch the optimal coordinated treatment mode according to different stages of wound healing, ensuring the scientific nature and consistency of the treatment plan and avoiding the errors and delays that may occur when manually coordinating two independent devices.

[0033] Reduced medical costs and resource consumption: The integrated design reduces reliance on independent hyperbaric oxygen chambers and distributed electrical stimulation devices, especially making the application of hyperbaric oxygen in local or microenvironment possible. This reduces the complexity and cost of equipment purchase, maintenance and operation, making this efficient synergistic therapy easier to promote and popularize in general wards and even in home environments in the future.

[0034] 4. Expanding the scope of treatment indications: Through the synergistic effect of the two therapies, this system is expected to expand the treatment scope to complex burn cases where traditional single therapies are ineffective.

[0035] Enhanced Treatment for Deep Burns: For deep burns, single therapies are often insufficient to effectively promote healing. The synergistic effect of this system can more effectively penetrate deep tissues, promote the reconstruction of deep vascular networks and tissue regeneration, and create better bed conditions for conservative treatment of deep burns or for skin grafting surgery.

[0036] Treatment of refractory wounds: For burn patients with infection, diabetes, or circulatory disorders, their wound healing ability is extremely poor. The system's strong anti-inflammatory and antibacterial (dual action of electrical stimulation + hyperbaric oxygen) and strong repair-promoting ability can provide a powerful new treatment option for these refractory wounds.

[0037] In summary, the main technical effect of this invention is that through technical integration and synergy, it achieves a qualitative leap in burn healing efficiency, overcomes the inherent defects of existing technologies, and provides a new burn treatment strategy that is more efficient, convenient, safe, and has a wider range of indications. Attached Figure Description

[0038] Figure 1 This is a schematic diagram of the structure of the electrical stimulation module according to a preferred embodiment of the present invention.

[0039] Figure 2 This is a schematic diagram of the structure of the electrical stimulation module and the conductive functional elastomer according to a preferred embodiment of the present invention.

[0040] Figure 3-4 This is a schematic diagram of the structure of the electrostimulation-assisted hyperbaric oxygen system for promoting burn healing, which is a preferred embodiment of the present invention.

[0041] Figure 5 The results show the comparative effects of electrical stimulation, hyperbaric oxygen, and the synergistic intervention of the two on cell repair behavior in a preferred embodiment of the present invention. Detailed Implementation

[0042] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0043] For ease of description, only the parts relevant to the present invention are shown in the accompanying drawings. The terms "first," "second," etc., used in this invention are merely for the convenience of describing the technical solutions of the invention and do not have a specific limiting effect; they are all general references and do not constitute a limitation on the technical solutions of the present invention. It should be noted that, unless otherwise specified, the embodiments and features in the embodiments of this application can be combined with each other. Terms indicating positional relationships, such as "middle," "horizontal," "vertical," "longitudinal," "front," "rear," "left," "right," "inner," and "outer," are based on the positional relationships shown in the illustrated drawings and do not imply that the components referred to must be presented in the described positional relationships, and do not constitute a limitation on the technical solutions of the present invention.

[0044] like Figure 1-4 As shown, this embodiment provides an electrical stimulation combined with hyperbaric oxygen therapy to promote burn healing, which includes an electrical stimulation module 10 for providing electrical stimulation to the burn wound area, a conductive functional elastomer 20, a hyperbaric oxygen module 30 for providing hyperbaric oxygen supply to the burn wound area, a monitoring module, and a control module.

[0045] The electrical stimulation module 10 includes a positive electrode 11 and a negative electrode 12 of an external electrical stimulation device (existing device). Both the positive electrode 11 and the negative electrode 12 include a base layer at the bottom, an adhesive layer in the middle, and a conductive layer at the top. The base layer is made of a PI substrate film; the adhesive layer is made of a titanium film and is used to increase the adhesion between the conductive layer and the base layer; the conductive layer uses gold (Au), which has good stability and biocompatibility, as the conductive material and is deposited on the surface of the titanium film.

[0046] See details Figure 1 The positive electrode 11 is integrally formed by a non-closed large circular ring electrode 111, the first straight electrodes 112 at both ends of the large circular ring electrode 111, and the first electrode plates 113 at the ends of the two first straight electrodes 112. The large circular ring electrode 111 and the first straight electrodes 112 are both curved structures, and the two first straight electrodes 112 are inclined outward to form a figure-eight shape.

[0047] The negative electrode 12 is placed on the central axis of the inner cavity of the positive electrode 11 and does not contact the positive electrode 11. The negative electrode 12 is integrally formed by a closed small circular electrode 121, a second straight electrode 122 connected to the small circular electrode 121, and a second electrode plate 123 at the end of the second straight electrode 122. Both the small circular electrode 121 and the second straight electrode 122 have curved structures, and the second straight electrode 122 is vertical.

[0048] The designed electrical stimulation module drawings are input into an ultraviolet laser engraving device. The area outside the pattern is etched by laser to achieve patterned cutting, and the electrical stimulation module is manufactured quickly and at low cost.

[0049] Conductive functional elastomer 20: Possessing elasticity, airtightness, adhesion, and conductivity, it comprises a ring-shaped elastic body with an adhesive layer on its surface. The ring-shaped elastic body, which provides mechanical properties, is a fully cured Ecoflex (the Ecoflex series is a two-component silicone material, consisting of liquid A and liquid B). Nanofiber silver particles or conductive graphene can be added to the ring-shaped elastic body to impart elasticity, airtightness, and conductivity. The adhesive layer is composed of Ecoflex liquid A, Ecoflex liquid B, and slack softener (soft wax / semi-refined paraffin wax) in a 1:1:1 ratio. The Ecoflex curing process is existing technology.

[0050] Hyperbaric oxygen module 30: Provides a long-term, stable and controllable supply of hyperbaric oxygen to the burn wound area, including a hyperbaric oxygen bladder 31 for storing hyperbaric oxygen, which is connected to an external hyperbaric oxygen inflation device (existing equipment). The hyperbaric oxygen bladder 31 is made of an oxygen storage bladder material that combines high airtightness, pressure resistance, flexibility and biocompatibility. The hyperbaric oxygen bladder 31 has an air outlet 32.

[0051] The hyperbaric oxygen chamber 31 is integrated with the electrodes in the electrical stimulation module 10 via a conductive functional elastomer 20, forming a single structure. Both the positive electrode 11 and the negative electrode 12 are positioned at the outlet 32 ​​of the hyperbaric oxygen chamber 31 and fixed by the conductive functional elastomer 20. Specifically, a large circular electrode 111 is arranged around the outlet 32 ​​of the hyperbaric oxygen chamber 31, and the conductive functional elastomer 20 wraps around the large circular electrode 111 and adheres to the outlet 32 ​​of the hyperbaric oxygen chamber 31. A second linear electrode 122 is adhered to the inner side of the conductive functional elastomer 20, and a small circular electrode 121 is located at the outlet 32 ​​of the hyperbaric oxygen chamber 31. Optimizing the connection method between the conductive functional elastomer and the electrodes reduces the interface resistance of the connection area, avoiding attenuation of the electrical stimulation output and uneven spatial distribution caused by local potential voltage division.

[0052] Based on the spatial arrangement of the electrical stimulation electrodes, a sensor area and lead-wire channel are designed between the positive and negative electrodes to avoid the influence of electrical stimulation output on the sensing signal, while ensuring the overall flexibility and attachability of the module. A small-sized, highly sensitive, and flexibly integrated pressure sensor and a miniature oxygen concentration sensor are selected as the monitoring module and integrated into the sensor area. Specifically, the sensing area is formed between the large circular electrode 111 and the small circular electrode 121, and the lead-wire channel is formed between the first linear electrode 112 and the second linear electrode 122. A pressure sensor 41 and a miniature oxygen concentration sensor 42 are placed in the sensing area, with the pressure sensor 41 and the miniature oxygen concentration sensor 42 respectively positioned on both sides of the small circular electrode 121. The lead-wire channel contains the wires 43 of the pressure sensor 41 and the miniature oxygen concentration sensor 42. The wires 43 of both the pressure sensor 41 and the miniature oxygen concentration sensor 42 are adhered to the inner side of the conductive functional elastomer 20. The pressure sensor 41 and the miniature oxygen concentration sensor 42 are located at the outlet of the high-pressure oxygen bag.

[0053] The control module uses a controller, specifically an ESP32 series microcontroller.

[0054] The specific usage process of this electrical stimulation combined with hyperbaric oxygen therapy system for promoting burn healing is as follows:

[0055] The conductive functional elastomer 20 adheres to the edge of the burn wound area of ​​the injured person through an adhesive layer, so that the system is installed at the burn wound area, and the outlet 32 ​​of the high-pressure oxygen bag 31 faces the burn wound area. The burn wound area is generally concave relative to the surrounding skin, and the conductive functional elastomer 20 has a certain thickness (about 5 mm), so that the pressure sensor 41 and the miniature oxygen concentration sensor 42 do not come into contact with the burn wound area.

[0056] After installation, the process begins to promote healing of the burn wound area. The electrical stimulation device delivers electrical stimulation to the electrical stimulation module 10, while the hyperbaric oxygen filling device inflates the hyperbaric oxygen bag 31. The hyperbaric oxygen covers the burn wound area, providing a highly reliable and stable hyperbaric oxygen atmosphere. This hyperbaric oxygen environment allows for better electrical stimulation of the burn wound area. The combination of electrical stimulation and hyperbaric oxygen achieves a synergistic gain effect (1+1>2), making the cells in the burn wound area more sensitive and efficient in responding to electrical stimulation signals in an oxygen-rich environment, thus promoting the healing of the burn wound area.

[0057] During stimulation, the pressure sensor 41 can transmit the real-time detected pressure value to the control module, and the miniature oxygen concentration sensor 42 can transmit the real-time detected oxygen concentration value to the control module. The control module receives the pressure value from the pressure sensor 41 and the oxygen concentration value from the miniature oxygen concentration sensor 42 in real time. Based on the pressure value and oxygen concentration value, the control module realizes the coordinated regulation of the electrical stimulation parameters of the electrical stimulation device and the high-pressure oxygen parameters of the high-pressure oxygen filling device, so that the detected pressure value is within the target pressure value (2 to 2.5 atmospheres) and the detected oxygen concentration value is within the target oxygen concentration value (above 98%).

[0058] This embodiment also provides a method for manufacturing a system for promoting burn healing through electrical stimulation combined with hyperbaric oxygen therapy, including the following steps:

[0059] Step 1: Fabrication of the electrostimulation module: Design the structural drawings of the electrostimulation module in CAD software, input the structural drawings of the electrostimulation module into the ultraviolet laser engraving equipment, and achieve graphic cutting by laser etching of the area outside the graphic to manufacture the electrostimulation module 10.

[0060] The electrostimulation module 10 includes a positive electrode 11 and a negative electrode 12. Both the positive electrode 11 and the negative electrode 12 include a base layer at the bottom, an adhesive layer in the middle, and a conductive layer at the top. The positive electrode 11 is formed by sequentially splicing together a large, open circular electrode 111, first straight electrodes 112 at both ends of the large circular electrode 111, and first electrode plates 113 at the ends of the two first straight electrodes 112. The negative electrode 12 is placed in the inner cavity of the positive electrode 11 and does not contact the positive electrode 11. The negative electrode 12 is formed by sequentially splicing together a small, closed circular electrode 121, a second straight electrode 122 connected to the small circular electrode 121, and second electrode plates 123 at the ends of the second straight electrode 122. The large circular electrode 111 and the small circular electrode 121 form a sensing area, and the first straight electrode 112 and the second straight electrode 122 form a lead channel.

[0061] Step 2: Fabrication of conductive functional elastomer: Fabrication of a conductive functional elastomer 20 in the shape of a ring that matches the shape of the large ring electrode 111.

[0062] Step 3: Select the pressure sensor 41 and the miniature oxygen concentration sensor 42.

[0063] Step 4: The conductive functional elastomer 20 wraps around the large circular electrode 111, the second linear electrode 122 is fixed inside the conductive functional elastomer 20, the wires of the pressure sensor 41 and the miniature oxygen concentration sensor 42 are both fixed inside the conductive functional elastomer 20, and the pressure sensor 41 and the miniature oxygen concentration sensor 42 are placed in the sensing area, and the wires 43 of the pressure sensor 41 and the miniature oxygen concentration sensor 42 are placed in the lead wire channel.

[0064] Step 5: Adhere the conductive functional elastomer 20 installed in Step 4 around the outlet 42 of the high-pressure oxygen bag 31. The small circular electrode 121, the pressure sensor 41, and the miniature oxygen concentration sensor 42 are located at the outlet of the high-pressure oxygen bag 31, forming an integrated structure.

[0065] Step Six: The control module uses a controller, the positive electrode 11 and the negative electrode 12 are connected to an external electrical stimulation device, the high-pressure oxygen bag 31 is connected to an external high-pressure oxygen filling device, and the wires of the pressure sensor 41 and the miniature oxygen concentration sensor 42 are connected to the controller.

[0066] To compare the effects of electrical stimulation, hyperbaric oxygen, and the synergistic effect of both on cell repair behavior, such as Figure 5 As shown, HaCaT cells were first seeded in 6-well plates and cultured until a confluent monolayer formed. Linear scratching was then performed using a sterile 200 μL pipette tip to establish an in vitro cell migration model. The results showed that all treatment groups promoted the lateral migration of HaCaT cells, suggesting that they are beneficial to the re-epithelialization process of burn wounds, with the synergistic intervention group showing the most significant migration-promoting effect. Further HUVEC cell migration experiments showed that all treatment groups promoted endothelial cell migration, with the synergistic intervention group still exhibiting the best promoting effect. Endothelial cell tube formation experiments further indicated that the synergistic intervention group had a higher total tube length, more branching points, and a more complex network structure, suggesting a stronger pro-angiogenic capacity. These results indicate that the synergistic effect of electrical stimulation and hyperbaric oxygen therapy can simultaneously enhance epithelial cell migration and endothelial cell angiogenesis activity, potentially improving the local ischemic and hypoxic microenvironment of the wound and providing a more favorable biological basis for burn wound repair.

[0067] While specific embodiments of the present invention have been described above, those skilled in the art should understand that these are merely illustrative examples, and the scope of protection of the present invention is defined by the appended claims. Those skilled in the art can make various changes or modifications to these embodiments without departing from the principles and essence of the present invention, but all such changes and modifications fall within the scope of protection of the present invention.

Claims

1. A system for promoting burn healing through electrical stimulation combined with hyperbaric oxygen therapy, characterized in that, It includes an electrical stimulation module and a hyperbaric oxygen module that provide electrical stimulation and hyperbaric oxygen supply to the burn wound area respectively, a conductive functional elastomer, a monitoring module and a control module; The electrostimulation module includes a positive electrode and a negative electrode of an external electrostimulation device. Both the positive and negative electrodes include a base layer at the bottom, an adhesive layer in the middle, and a conductive layer at the top. The positive electrode is formed by sequentially splicing together a large, open circular electrode, first straight electrodes at both ends of the large circular electrode, and first electrode plates at the ends of the two first straight electrodes. The negative electrode is placed inside the cavity of the positive electrode and does not contact the positive electrode. The negative electrode is formed by sequentially splicing together a small, closed circular electrode, a second straight electrode connected to the small circular electrode, and second electrode plates at the ends of the second straight electrode. The large circular electrode and the small circular electrode form a sensing area, and the first straight electrode and the second straight electrode form a lead channel. The monitoring module includes a pressure sensor and a miniature oxygen concentration sensor. The sensing area contains the pressure sensor and the miniature oxygen concentration sensor, and the lead channel contains the wires of the pressure sensor and the miniature oxygen concentration sensor. The high-pressure oxygen module includes a high-pressure oxygen bladder connected to an external high-pressure oxygen filling device. The positive electrode, negative electrode, pressure sensor, and miniature oxygen concentration sensor are all placed at the outlet of the high-pressure oxygen bladder and fixed by a conductive functional elastomer to form an integrated structure. The control module is used to receive the air pressure value from the air pressure sensor and the oxygen concentration value from the micro oxygen concentration sensor in real time. Based on the air pressure value and oxygen concentration value, it realizes the coordinated regulation of the electrical stimulation parameters of the electrical stimulation device and the high-pressure oxygen parameters of the high-pressure oxygen filling device, so that the detected air pressure value is within the target air pressure value and the detected oxygen concentration value is within the target oxygen concentration value.

2. The electrical stimulation-assisted hyperbaric oxygen therapy system for promoting burn healing as described in claim 1, characterized in that, The large circular electrode is arranged around the outlet of the high-pressure oxygen bag. The conductive functional elastomer wraps around the large circular electrode and is bonded to the outlet of the high-pressure oxygen bag. The wires of the second linear electrode, the pressure sensor and the miniature oxygen concentration sensor are all bonded to the inside of the conductive functional elastomer. The small circular electrode, the pressure sensor and the miniature oxygen concentration sensor are located at the outlet of the high-pressure oxygen bag.

3. The electrical stimulation-assisted hyperbaric oxygen therapy system for promoting burn healing as described in claim 1, characterized in that, The pressure sensor and the miniature oxygen concentration sensor are respectively positioned on both sides of the small circular electrode.

4. The electrical stimulation combined with hyperbaric oxygen therapy to promote burn healing system as described in claim 1, characterized in that, Both the large circular electrode and the first straight electrode have curved structures, as do the small circular electrode and the second straight electrode.

5. The electrical stimulation-assisted hyperbaric oxygen therapy system for promoting burn healing as described in claim 1, characterized in that, The two first linear electrodes are tilted outwards, and the second linear electrode is vertical.

6. The electrical stimulation-assisted hyperbaric oxygen therapy system for promoting burn healing as described in claim 1, characterized in that, The negative electrode is placed on the central axis of the inner cavity of the positive electrode.

7. The electrical stimulation-assisted hyperbaric oxygen therapy system for promoting burn healing as described in claim 1, characterized in that, The conductive functional elastomer includes a ring-shaped elastic body, and an adhesive layer is provided on the surface of the ring-shaped elastic body.

8. The electrical stimulation-assisted hyperbaric oxygen therapy system for promoting burn healing as described in claim 7, characterized in that, The circular elastic body is made of fully cured Ecoflex, with nanofiber silver particles or conductive graphene added inside, so that the circular elastic body has elasticity, airtightness and conductivity. The adhesive layer is composed of Ecoflex A liquid, Ecoflex B liquid and Slack softener in a 1:1:1 ratio.

9. A method for manufacturing a system for promoting burn healing through electrical stimulation combined with hyperbaric oxygen therapy, characterized in that, Includes the following steps: Step 1: Fabrication of the electrostimulation module: Design the structural drawings of the electrostimulation module in CAD software, input the structural drawings of the electrostimulation module into the ultraviolet laser engraving equipment, and achieve graphic cutting by laser etching of the area outside the graphic to manufacture the electrostimulation module; The electrostimulation module structure includes a positive electrode and a negative electrode. Both the positive and negative electrodes include a base layer at the bottom, an adhesion layer in the middle, and a conductive layer at the top. The positive electrode is formed by sequentially splicing together a large, open circular electrode, first straight electrodes at both ends of the large circular electrode, and first electrode plates at the ends of the two first straight electrodes. The negative electrode is placed inside the cavity of the positive electrode and does not contact the positive electrode. The negative electrode is formed by sequentially splicing together a small, closed circular electrode, a second straight electrode connected to the small circular electrode, and second electrode plates at the ends of the second straight electrode. The large circular electrode and the small circular electrode form a sensing area, and the first straight electrode and the second straight electrode form a lead channel. Step 2: Fabrication of a conductive functional elastomer: Fabrication of a conductive functional elastomer in the shape of a ring that matches the shape of the large ring electrode; Step 3: Select the barometric pressure sensor and the miniature oxygen concentration sensor; Step 4: The conductive functional elastomer wraps around the large circular electrode, the second linear electrode is fixed inside the conductive functional elastomer, the wires of the pressure sensor and the miniature oxygen concentration sensor are both fixed inside the conductive functional elastomer, and the pressure sensor and the miniature oxygen concentration sensor are placed in the sensing area, and the wires of the pressure sensor and the miniature oxygen concentration sensor are placed in the lead wire channel. Step 5: Adhere the conductive functional elastomer installed in Step 4 around the outlet of the high-pressure oxygen bag. The small ring electrode, pressure sensor and micro oxygen concentration sensor are located at the outlet of the high-pressure oxygen bag, forming an integrated structure. Step Six: Select a controller for the control module, connect the positive and negative electrodes to an external electrical stimulation device, connect the high-pressure oxygen bag to an external high-pressure oxygen filling device, and connect the wires of the pressure sensor and the miniature oxygen concentration sensor to the controller.

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