Microsphere preparation device and microsphere preparation system

Abstract

The microsphere preparation device disclosed in the application comprises a main body, an accommodating cavity is formed in the main body, the accommodating cavity comprises a first chamber and a second chamber, a microporous membrane is arranged between the first chamber and the second chamber, and a plurality of first micropores are arranged on the microporous membrane; the main body comprises a flow uniformization module arranged in the second chamber, a plurality of guide flow channels are arranged on the flow uniformization module and are spaced from each other and communicated with the plurality of first micropores, at least one continuous phase inlet and at least one continuous phase outlet, one end of the guide flow channel is communicated with the at least one continuous phase inlet and the other end is communicated with the at least one continuous phase outlet, and a dispersed phase inlet is arranged on the main body and communicated with the first chamber. The microsphere preparation device provided in the embodiment realizes stable transmembrane penetration of the dispersed phase, uniform distribution of the continuous phase along the surface of the microporous membrane and formation of a stable shear force field, so that the technical problems of poor uniformity of the particle size of the microsphere product and unstable preparation precision of batches are solved.

Description

Technical Field

[0001] This invention relates to the field of microsphere preparation technology, and more particularly to a microsphere preparation apparatus and a microsphere preparation system. Background Technology

[0002] The particle size and size distribution of microspheres are important indicators reflecting the performance of drug microspheres. Precise control of microsphere size uniformity is crucial for controlling pharmacokinetic behavior of drugs in vivo, improving formulation quality, and facilitating industrial production applications. Membrane emulsification technology, with its outstanding advantage in preparing monodisperse microspheres, is currently the core process for high-precision microsphere preparation. By adjusting process parameters, it can be adapted to the preparation of various types of emulsion microspheres and is widely used in pharmaceutical formulation research and production.

[0003] Currently, conventional membrane emulsification preparation devices generally adopt an integrated single-cavity structure. For example, Chinese patent application number 200510047329.4 discloses a membrane emulsification preparation process for monodisperse porous microspheres. The equipment cavity adopts an integrally connected single-cavity structure, where the dispersed phase and continuous phase directly and simultaneously complete fluid flow and microsphere formation within this unified cavity. In this structure, the continuous phase relies solely on the disordered flow within the cavity's free space. The overall fluid flow direction is chaotic, and the velocity distribution varies greatly. When the fluid flows across the microporous membrane surface, the flow field distribution is extremely uneven, making it impossible to construct a stable, uniform, and continuous shear force field on the microporous membrane surface. The fluid shear intensity exhibits localized unevenness, making it difficult to precisely match the uniform and stable droplet formation rhythm of the dispersed phase across the membrane. Ultimately, this results in poor uniformity of the prepared microsphere particle size and insufficient product precision and stability.

[0004] Therefore, how to achieve independent and orderly flow of the dispersed phase and the continuous phase in separate zones, thereby forming a stable shear force field on the membrane surface and improving the precision and uniformity of microsphere preparation, is a technical problem that urgently needs to be solved in this field. Summary of the Invention

[0005] To address at least some of the problems and defects in the prior art, embodiments of the present invention disclose a microsphere preparation apparatus and a microsphere preparation system. By dividing the interior of the main body into independent cavities for the passage of the dispersed phase and the continuous phase, and by providing a flow equalization module with multiple spaced guide channels, the dispersed phase achieves stable transmembrane permeation, and the continuous phase is uniformly distributed along the surface of the microporous membrane to form a stable shear force field. This solves the technical problems of poor particle size uniformity and unstable batch preparation accuracy of the microspheres.

[0006] Specifically, an embodiment of the present invention provides a microsphere preparation apparatus, comprising: a main body having an internal accommodating cavity, the accommodating cavity including a first chamber and a second chamber; a microporous membrane disposed between the first chamber and the second chamber, the microporous membrane having a plurality of first micropores configured to allow the dispersed phase to enter from the first chamber into the second chamber; wherein, the main body includes: a flow equalization module disposed within the second chamber, the flow equalization module having a plurality of mutually spaced guide channels communicating with the plurality of first micropores; at least two continuous phase ports disposed on the main body, the at least two continuous phase ports being configured as at least one continuous phase inlet and at least one continuous phase outlet, one end of the guide channel communicating with the at least one continuous phase inlet and the other end communicating with the at least one continuous phase outlet, the guide channel being used to guide the continuous phase onto the microporous membrane; and a dispersed phase inlet disposed on the main body and communicating with the first chamber, used to guide the dispersed phase into the first chamber.

[0007] In one embodiment of the present invention, the main body includes a top cover and a base, the top cover and the microporous membrane enclose each other to form a second chamber, the microporous membrane and the base enclose each other to form a first chamber, and the microporous membrane is located on the side of the base near the top cover.

[0008] In one embodiment of the invention, the dispersed phase inlet is located on the side of the base; and / or, the at least two consecutive phase ports are located on the side of the top cover.

[0009] In one embodiment of the present invention, the number of continuous phase ports is four, and the four continuous phase ports are symmetrically distributed. Any two continuous phase ports located diagonally are respectively configured as the continuous phase inlet and the continuous phase outlet.

[0010] In one embodiment of the present invention, the microporous membrane includes multiple micropore rows, each micropore row having multiple first micropores, the multiple micropore rows being connected to and corresponding one-to-one with the multiple guide channels; and / or, the top cover having multiple diversion holes at one end near the base, the multiple diversion holes being connected to and corresponding one-to-one with the multiple guide channels.

[0011] In one embodiment of the present invention, a micropore array distribution area is provided on the side of the base near the microporous membrane, the micropore array distribution area is connected to the dispersed phase inlet, and the micropore array distribution area includes a plurality of second micropores, the second micropores being matched with the first micropores.

[0012] In one embodiment of the present invention, the main body further includes an observation window portion, and a second mounting portion is provided on the side of the top cover away from the accommodating cavity. The observation window portion is embedded in the second mounting portion and extends to the flow equalization module at one end near the accommodating cavity.

[0013] In one embodiment of the present invention, the main body further includes a top fixing plate, a first sealing ring is provided between the observation window and the top cover, and the top fixing plate is disposed on the side of the observation window away from the top cover and is tightly connected to the top cover by bolts.

[0014] In one embodiment of the present invention, the main body further includes a central fixing plate, which is disposed in the accommodating cavity and located between the top cover and the flow equalization module. The central fixing plate and the flow equalization module are embedded together in the second cavity, and a second sealing ring and a third sealing ring are disposed between the top cover and the central fixing plate.

[0015] On the other hand, embodiments of the present invention also provide a microsphere preparation system, including a microsphere preparation apparatus as described above, a dispersed phase conveying mechanism for conveying a dispersed phase to the microsphere preparation apparatus, and a continuous phase conveying mechanism for conveying a continuous phase to the microsphere preparation apparatus; wherein, the dispersed phase conveying mechanism includes a dispersed phase storage tank, a first peristaltic pump, and a first mass flow meter connected in sequence, the first mass flow meter being connected to the dispersed phase inlet on the microsphere preparation apparatus; the continuous phase conveying mechanism includes a continuous phase storage tank, a second peristaltic pump, and a second mass flow meter connected in sequence, the second mass flow meter being connected to at least one continuous phase inlet on the microsphere preparation apparatus.

[0016] As can be seen from the above, the technical features of the present invention can have one or more of the following beneficial effects: The microsphere preparation device provided in this embodiment, by setting an independent first chamber and a second chamber inside the main body, and configuring a flow equalization module with multiple spaced guide channels in the second chamber, and using the guide channels to uniformly divide and stabilize the continuous phase, enables the continuous phase to form a continuous, uniform and stable transverse shear force field along the microporous membrane surface, ensuring that the shearing action of the continuous phase and the droplet formation process of the dispersed phase across the membrane are precisely matched and coordinated, effectively improving the uniformity and stability of droplet peeling and forming, significantly improving the uniformity of microsphere particle size, reducing the dispersion of microsphere particle size distribution, stabilizing the overall preparation accuracy, effectively solving the technical defects of uneven preparation and poor batch stability of traditional single-chamber structure microspheres, and meeting the industrial preparation requirements of high-precision monodisperse microspheres. Attached Figure Description

[0017] To more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0018] Figure 1 This is an exploded structural diagram of the microsphere preparation apparatus provided in an embodiment of the present invention.

[0019] Figure 2 for Figure 1 A schematic diagram of the overall structure of the microsphere preparation device.

[0020] Figure 3 for Figure 1 A schematic cross-sectional view of the microsphere preparation device at the continuous phase port.

[0021] Figure 4 for Figure 1 Front view of the microsphere preparation apparatus.

[0022] Figure 5 for Figure 1 A schematic diagram of the structure of the top cover and the viewing window.

[0023] Figure 6 This is a schematic diagram of the microsphere preparation system provided in an embodiment of the present invention. Detailed Implementation

[0024] To make the objectives, technical solutions, and advantages of this invention clearer, the technical solutions of this invention will be clearly and completely described below in conjunction with specific embodiments and corresponding drawings. Obviously, the described embodiments are only a part of the embodiments of this invention, and not all of them. Based on the embodiments of this invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this invention.

[0025] It should be noted that the directional terms mentioned in the embodiments of this invention, such as "up," "down," "front," "back," "left," "right," "inner," "outer," and "side," are only for reference to the accompanying drawings. Therefore, the directional terms used are for illustrating and understanding this invention, and not for limiting this invention. For the sake of understanding and ease of description, the dimensions and thicknesses of each component shown in the drawings are arbitrarily shown, but the invention is not limited thereto.

[0026] It is understood that when a component, such as a layer, membrane, region, or substrate, is referred to as "on" another component, the component may be directly on the other component, or there may be intermediate components present. Furthermore, in the specification, unless explicitly stated otherwise, the word "comprising" will be understood to mean including the stated component, but not excluding any other components. Additionally, in the specification, "on" means located above or below the target component, and does not mean necessarily located on top of it based on gravity.

[0027] The following detailed description of some embodiments of the present invention is provided in conjunction with the accompanying drawings. Unless otherwise specified, the following embodiments and features described herein can be combined with each other.

[0028] This invention discloses a microsphere preparation device 10, which is mainly used for the precise preparation of monodisperse microspheres using membrane emulsification. It is adaptable to various microsphere formulation systems, including O / W, W / O, and W1 / O / W2 types. For details, see [link to documentation]. Figures 1-4 The microsphere preparation apparatus 10 includes a main body 100 and a microporous membrane 200 assembled inside the main body 100. A receiving cavity 101 is formed inside the main body 100, comprising a first chamber 1011 and a second chamber 1012, wherein the first chamber 1011 is for passage of the dispersed phase, and the second chamber 1012 is for passage of the continuous phase. See also... Figure 3 and Figure 4 A microporous membrane 200 is fixedly disposed between the first chamber 1011 and the second chamber 1012. A plurality of first micropores are uniformly distributed on the surface of the microporous membrane 200. These first micropores allow the dispersed phase to enter the second chamber 1012 from the first chamber 1011. During operation, the dispersed phase can pass through the first micropores under pressure differential and stably permeate to the side of the microporous membrane 200 facing the second chamber 1012, providing a stable foundation for microsphere droplet formation. This embodiment, by partitioning the accommodating chamber 101, enables the dispersed phase and continuous phase fluids to operate independently, structurally avoiding the problems of cross-flow and turbulent flow field of the two phases, effectively ensuring the stability of the dispersed phase droplet formation process, and providing structural protection for the preparation of highly uniform microspheres.

[0029] For details, please refer to [link / reference]. Figure 1 and Figure 3 and Figure 4The main body 100 integrates a flow equalization module 150, a continuous phase port 102, and a dispersed phase inlet 103. The flow equalization module 150 is assembled inside the second chamber 1012 and has multiple spaced-apart guide channels 151, each corresponding to and connected to multiple first micropores on the microporous membrane 200. At least two continuous phase ports 102 are provided on the outer surface of the main body 100, each configured as at least one continuous phase inlet and at least one continuous phase outlet. The two ends of the guide channels 151 are respectively connected to the continuous phase inlet and the continuous phase outlet, allowing the continuous phase to be introduced into the guide channels 151 through the continuous phase inlet. Under the constraint and guidance of the guide channels 151, the continuous phase uniformly covers the surface of the microporous membrane 200 near the second chamber 1012, forming a stable transverse scouring flow field. The dispersed phase inlet 103 is located on the main body 100 and communicates with the first chamber 1011. It is used to receive the dispersed phase fluid transported from the outside and to precisely guide the dispersed phase to the surface of the microporous membrane 200 near the first chamber 1011. Through the cooperative structure of the flow equalization module 150 and the guide channel 151, the second chamber 1012 can be divided into several independent channels to achieve uniform flow distribution and stable flow guidance of the continuous phase, forming a stable and uniform shear force field on the membrane surface. It can also ensure that the continuous phase flows in only one direction to avoid the re-aggregation of unformed pellets caused by lateral turbulence, thereby improving the uniformity of pellet formation.

[0030] Specifically, in the membrane emulsified microsphere preparation system, the fluid is divided into two immiscible liquid phases: a dispersed phase and a continuous phase. The dispersed phase is the raw material liquid phase constituting the microsphere matrix and is the main material ultimately forming the microspheres. The continuous phase is a flowing carrier liquid phase used to apply fluid shear force to the dispersed phase droplets that have permeated to the other side of the microporous membrane, causing the dispersed phase droplets to peel off from the microporous membrane surface. The peeled droplets shrink under interfacial tension to form spherical microspheres. The continuous phase and the formed microspheres flow out together from the continuous phase outlet to obtain the target microspheres. When the microsphere preparation apparatus provided in this application is in operation, the dispersed phase enters the first chamber 1011 through the dispersed phase inlet 103 and covers the side of the microporous membrane 200. It then permeates vertically through the first micropores on the microporous membrane 200 at a constant flow rate and in a uniform shape to the side of the microporous membrane 200 near the second chamber 1012 to form nascent droplets. The continuous phase enters the guide channel 151 of the flow equalization module 150 through the continuous phase inlet. Under the constraint of the flow channel, it flows laterally and uniformly along the side of the microporous membrane 200 near the second chamber 1012, forming a stable and uniform shear force field on the membrane surface. When the initial droplets of the dispersed phase on the surface of the microporous membrane 200 grow to the critical size, the lateral shear force of the continuous phase overcomes the adhesion between the droplets and the membrane surface, peeling the droplets off the membrane surface. The peeled droplets shrink into regular spheres under the spontaneous action of the interfacial tension between the two phases, forming monodisperse microspheres with uniform particle size, and flow out from the continuous phase outlet along with the continuous phase fluid, completing the continuous microsphere preparation process.

[0031] For details, see Figure 1 The main body 100 includes a top cover 130 and a base 170. The top cover 130 and the upper plate of the microporous membrane 200 enclose each other to form a second chamber 1012, and the lower plate of the microporous membrane 200 and the base 170 enclose each other to form a first chamber 1011. This layered enclosing structure achieves physical isolation between the two chambers, resulting in a compact structure and stable partitioning effect. For example, see... Figure 3 For example, a distribution channel is provided on the top cover 130, which connects to the continuous phase port 102 to distribute the continuous phase received by the continuous phase port 102 to the flow equalization module 150. The microporous membrane 200 is horizontally mounted on the end face of the base 170 near the top cover 130, with high assembly flatness, which can effectively ensure the uniformity of vertical transmembrane exudation of the dispersed phase. This split assembly structure facilitates the disassembly, maintenance and replacement of each component, and can be flexibly replaced with microporous membranes 200 of different pore sizes and materials, greatly improving the adaptability and versatility of the equipment.

[0032] Furthermore, during the vertical transmembrane exudation of microspheres, the oil phase, as the dispersed phase, has a lower density than the aqueous phase, the continuous phase. Therefore, when the oil phase microspheres are sheared off the membrane surface, they naturally float upwards, thus avoiding the microspheres on the surface of the microporous membrane 200 that have not yet been sheared, preventing them from agglomerating. This upward separation mechanism allows the microspheres in the guide channel to move forward in an orderly and non-interfering manner. In one specific embodiment, see [link to specific implementation]. Figure 2 The dispersed phase inlet 103 is located on the side of the base 170, and / or the continuous phase port 102 is located on the side of the top cover 130. This layered, staggered layout achieves separate inlet and outlet arrangements for the dispersed and continuous phases, completely avoiding interference between the two-phase fluid inlet and outlet pipelines. This further ensures independent and non-interfering transport of the two fluids, simplifies the equipment pipeline layout, and improves the overall structural regularity and fluid transport stability of the equipment.

[0033] Preferably, see Figure 3 Four continuous phase ports 102 are provided, which are centrally symmetrically distributed on the side of the top cover 130. The two diagonally arranged continuous phase ports 102 are configured as the continuous phase inlet and outlet, respectively. Compared with the single-inlet and single-outlet structure, the symmetrical diagonal inlet and outlet structure enables the continuous phase to form a uniform circulating flow field throughout the guide channel 151, eliminating dead zones and local velocity differences, further improving the uniformity of the membrane shear force field, avoiding the problem of uneven microsphere size caused by excessive or insufficient local shear force, and further optimizing the uniformity of microsphere size.

[0034] As stated above, see also Figure 5 The microporous membrane 200 has multiple rows of micropores arranged on its surface. Each row contains several uniformly distributed first micropores. These rows of micropores are connected one-to-one with multiple guide channels 151 of the flow equalization module 150, ensuring that the continuous phase flow in each guide channel 151 can accurately correspond to the liquid outlet position of the corresponding micropore, achieving fixed-point, directional, and uniform shearing. Simultaneously, the top cover 130 has multiple diversion holes 133 on its end face near the base 170. These diversion holes 133 are connected one-to-one with the guide channels 151. After the continuous phase enters the top cover 130, it can be evenly diverted through the diversion holes 133 into each guide channel 151, achieving secondary equalization and stabilization of the flow, further improving the uniformity of the continuous phase distribution and ensuring consistent shearing effect across the entire membrane surface.

[0035] Further, see Figure 1 and Figure 4A micropore array distribution area 171 is provided on the end face of the base 170 near the microporous membrane 200. The micropore array distribution area 171 is directly connected to the dispersed phase inlet 103 on the side of the base 170. A number of second micropores are arranged inside the micropore array distribution area 171. The pore size and arrangement of the second micropores are matched with the first micropores on the upper microporous membrane 200. After the dispersed phase enters the device through the dispersed phase inlet 103, it first undergoes uniform distribution through the micropore array distribution area 171, so that the dispersed phase pressure and flow rate are uniformly distributed in the first chamber 1011. This ensures that the amount of dispersed phase permeation in each area of ​​the entire microporous membrane 200 is uniform and consistent, avoiding deviations in sphere size caused by local differences in liquid output, and further improving the consistency of microsphere batch preparation.

[0036] In one specific implementation, see Figure 1 The main body 100 is also equipped with an observation window 120. A second mounting portion 132 is provided on the end face of the top cover 130 away from the accommodating cavity 101. The observation window 120 is embedded inside the second mounting portion 132, and the end of the observation window 120 near the accommodating cavity 101 extends to the position of the flow equalization module 150. Operators can observe the internal flow field state, droplet generation, and peeling process in real time through the observation window 120. This allows for real-time monitoring of equipment operation, timely detection of flow field anomalies, blockages, and flow interruptions, facilitating experimental parameter adjustment and production process monitoring, and improving equipment maintenance convenience and production controllability.

[0037] As stated above, see also Figure 1 The main body 100 has a top fixing plate 110 on top. A first sealing ring is provided at the assembly gap between the observation window 120 and the top cover 130. The top fixing plate 110 is pressed onto the side of the observation window 120 away from the top cover 130 and is locked and fixed to the top cover 130 by bolts. Through the pressing and fixing of the top fixing plate 110 and the sealing protection of the first sealing ring, the assembly gap of the window can be completely sealed, effectively preventing fluid leakage during equipment operation, ensuring the sealing performance of the accommodating cavity 101 and the stability of system pressure, providing a sealing basis for the stable pressure difference droplet formation of the dispersed phase, and improving the overall assembly firmness of the equipment.

[0038] In addition, a central fixing plate 140 is provided inside the main body 100. The central fixing plate 140 is arranged inside the accommodating cavity 101 between the top cover 130 and the flow equalization module 150. The central fixing plate 140 and the flow equalization module 150 are embedded together in the second chamber 1012. A second sealing ring and a third sealing ring are respectively provided between the assembly gap between the top cover 130 and the central fixing plate 140. The multi-layer sealing structure can progressively enhance the sealing performance of the second chamber 1012, eliminate the leakage and pressure relief of the continuous phase fluid, ensure the stability of the continuous phase flow field pressure and constant flow velocity, avoid pressure fluctuations causing shear force field disturbances, and further ensure the stability of microsphere molding.

[0039] In summary, the microsphere preparation apparatus provided in this embodiment, by setting up independent first chamber 1011 and second chamber 1012 inside the main body, and configuring a flow equalization module with multiple spaced guide channels in the second chamber 1012, enables the dispersed phase and continuous phase to achieve complete partitioning and independent orderly flow, completely avoiding the problems of cross interference of the two-phase fluid flow paths and flow field coupling disorder; at the same time, the guide channels are used to uniformly divide and stabilize the flow of the continuous phase, so that the continuous phase can form a continuous, uniform and stable transverse shear force field along the surface of the microporous membrane 200, ensuring that the shearing action of the continuous phase and the cross-membrane droplet formation process of the dispersed phase are precisely matched and coordinated, effectively improving the uniformity and stability of droplet peeling and forming, significantly improving the uniformity of microsphere particle size, reducing the dispersion of microsphere particle size distribution, stabilizing the overall preparation accuracy, effectively solving the technical defects of uneven preparation and poor batch stability of traditional single-chamber structure microspheres, and meeting the industrial preparation requirements of high-precision monodisperse microspheres.

[0040] See Figure 6 The present invention also discloses a microsphere preparation system 1, which includes the aforementioned microsphere preparation device 10, a dispersed phase conveying mechanism 20, and a continuous phase conveying mechanism 30. The dispersed phase conveying mechanism 20 is used to stably convey dispersed phase fluid to the microsphere preparation device 10. The dispersed phase conveying mechanism 20 is composed of a dispersed phase storage tank 21, a first peristaltic pump 22, and a first mass flow meter 23 connected in sequence via pipelines. The output end of the first mass flow meter 23 is connected to the dispersed phase inlet 103 of the microsphere preparation device 10. During operation, the first peristaltic pump 22 provides stable conveying power, and the first mass flow meter 23 monitors and controls the dispersed phase flow in real time and in a closed loop, achieving low-pulse, high-precision, and stable flow delivery of the dispersed phase, overcoming the shortcomings of traditional nitrogen pressurized feeding, such as large pressure fluctuations and low precision. The continuous phase conveying mechanism 30 is used to stably convey the continuous phase fluid to the microsphere preparation device 10. The continuous phase conveying mechanism 30 is composed of a continuous phase storage tank 31, a second peristaltic pump 32, and a second mass flow meter 33 connected in sequence through pipelines. The output end of the second mass flow meter 33 is connected to the continuous phase inlet of the microsphere preparation device 10, which can precisely control the continuous phase conveying flow rate and velocity to match different microsphere formation process requirements. This system achieves precise and controllable adjustment of the flow rate and pressure of the two-phase fluid through the linkage control mode of dual pumps and dual flow meters. Combined with the device's independent zoned flow and uniform shear structure, it can stably prepare highly monodisperse microspheres, adapting to the application scenarios of high-temperature resistant and organic solvent resistant metal microporous membranes 200, greatly expanding the process application range of membrane emulsification microsphere preparation, and meeting the needs of high-precision mass production in industrial applications.

[0041] It is understood that the foregoing embodiments are merely illustrative examples of the present invention. Provided that the technical features do not conflict, the structure is not contradictory, and the purpose of the invention is not violated, the technical solutions of the various embodiments can be arbitrarily combined and used.

[0042] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A microsphere preparation apparatus (10), characterized in that, include: The main body (100) has an internal cavity (101) which includes a first chamber (1011) and a second chamber (1012). A microporous membrane (200) is disposed between the first chamber (1011) and the second chamber (1012). The microporous membrane (200) is provided with a plurality of first micropores, which are used to allow the dispersed phase to enter from the first chamber (1011) into the second chamber (1012). The main body (100) includes: A flow equalization module (150) is disposed in the second chamber (1012). The flow equalization module (150) is provided with multiple guide channels (151) that are spaced apart from each other and connected to the plurality of first micropores. At least two continuous phase ports (102) are disposed on the body (100), the at least two continuous phase ports (102) are configured as at least one continuous phase inlet and at least one continuous phase outlet, one end of the guide channel (151) is connected to the at least one continuous phase inlet and the other end is connected to the at least one continuous phase outlet, the guide channel (151) is used to guide the continuous phase onto the microporous membrane (200); A dispersed phase inlet (103) is disposed on the main body (100) and connected to the first chamber (1011) for guiding the dispersed phase into the first chamber (1011).

2. The microsphere preparation apparatus (10) as described in claim 1, characterized in that, The main body (100) includes a top cover (130) and a base (170). The top cover (130) and the microporous membrane (200) enclose a second chamber (1012), and the microporous membrane (200) and the base (170) enclose a first chamber (1011). The microporous membrane (200) is located on the side of the base (170) near the top cover (130).

3. The microsphere preparation apparatus (10) as described in claim 2, characterized in that, The dispersed phase inlet (103) is located on the side of the base (170); and / or, the at least two continuous phase ports (102) are located on the side of the top cover (130).

4. The microsphere preparation apparatus (10) as described in claim 2, characterized in that, The number of continuous phase ports (102) is four, and the four continuous phase ports (102) are symmetrically distributed. Any two continuous phase ports (102) located diagonally opposite each other are configured as the continuous phase inlet and the continuous phase outlet, respectively.

5. The microsphere preparation apparatus (10) as described in claim 2, characterized in that, The microporous membrane (200) includes multiple rows of micropores, each row of micropores having multiple first micropores, the multiple rows of micropores being connected to and corresponding one-to-one with the multiple guide channels (151); and / or, The top cover (130) is provided with a plurality of diversion holes (133) at one end near the base (170). The plurality of diversion holes (133) are connected to and correspond one-to-one with the plurality of guide channels (151).

6. The microsphere preparation apparatus (10) as described in claim 2, characterized in that, The base (170) has a micropore array distribution area (171) on the side near the microporous membrane (200). The micropore array distribution area (171) is connected to the dispersed phase inlet (103). The micropore array distribution area (171) includes a plurality of second micropores, which are matched with the first micropores.

7. The microsphere preparation apparatus (10) as described in claim 2, characterized in that, The main body (100) also includes an observation window (120), and a second mounting part (132) is provided on the side of the top cover (130) away from the accommodating cavity (101). The observation window (120) is embedded in the second mounting part (132) and extends to the flow equalization module (150) at one end near the accommodating cavity (101).

8. The microsphere preparation apparatus (10) as described in claim 7, characterized in that, The main body (100) also includes a top fixing plate (110), a first sealing ring is provided between the observation window (120) and the top cover (130), the top fixing plate (110) is located on the side of the observation window (120) away from the top cover (130) and is tightly connected to the top cover (130) by bolts.

9. The microsphere preparation apparatus (10) as described in claim 2, characterized in that, The main body (100) also includes a central fixing plate (140), which is disposed in the accommodating cavity (101) and located between the top cover (130) and the flow equalization module (150). The central fixing plate (140) and the flow equalization module (150) are embedded together in the second chamber (1012). A second sealing ring and a third sealing ring are provided between the top cover (130) and the central fixing plate (140).

10. A microsphere preparation system (1), characterized in that, Includes a microsphere preparation apparatus (10) as described in any one of claims 1-9, a dispersed phase conveying mechanism for conveying a dispersed phase to the microsphere preparation apparatus (10), and a continuous phase conveying mechanism for conveying a continuous phase to the microsphere preparation apparatus (10); The dispersed phase conveying mechanism (20) includes a dispersed phase storage tank (21), a first peristaltic pump (22) and a first mass flow meter (23) connected in sequence. The first mass flow meter (23) is connected to the dispersed phase inlet (103) on the microsphere preparation device (10). The continuous phase conveying mechanism (30) includes a continuous phase storage tank (31), a second peristaltic pump (32), and a second mass flow meter (33) connected in sequence. The second mass flow meter (33) is connected to at least one continuous phase inlet on the microsphere preparation device (10).

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