Traditional Chinese medicine processing and impurity removal method combined with ultrasonic treatment

Abstract

The application discloses a kind of traditional Chinese medicinal materials processing and impurity removal method combined with ultrasonic treatment, comprising the following steps: (S1) pretreatment stage: after the preliminary sorting of traditional Chinese medicinal materials raw materials, remove visible impurities, place in ultrasonic cleaning device, real-time remove suspended impurities;(S2) structure modification stage: the cleaned traditional Chinese medicinal materials are cut into sheet shape or granules with particle size ≤3 mm with thickness ≤5 mm, placed in closed ultrasonic reaction kettle, and processing auxiliary solution is added;(S3) impurity depth removal stage: the processed medicinal materials are transferred to multi-stage ultrasonic extraction device, and are treated step by step with polar gradient solvent;(S4) post-treatment stage: the treated medicinal materials are placed in vacuum freeze-drying system, after pre-freezing for 2-6 hours at-40 to-20℃, sublimation drying is carried out under the condition of vacuum degree ≤10 Pa, and 28 kHz ultrasonic vibration is applied to accelerate water migration, and finally the finished product medicinal materials with water content ≤8% are obtained.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine processing, and in particular to a method for processing and removing impurities from traditional Chinese medicinal materials by combining ultrasonic treatment. Background Technology

[0002] Processing of Chinese medicinal herbs is a crucial step in the production of traditional Chinese medicine, directly affecting their efficacy, safety, and stability. Traditional processing methods primarily rely on physical, chemical, or biological means, such as washing, stir-frying, steaming, and alcohol processing, to increase the content of active ingredients, remove impurities, or reduce toxicity. However, these methods generally suffer from the following problems:

[0003] Incomplete cleaning leaves impurities:

[0004] Traditional water washing methods are ineffective at removing pesticide residues, heavy metals, and microbial contamination from the surface of medicinal materials. Furthermore, the microporous structure of some medicinal materials can adsorb contaminants, affecting their quality.

[0005] Poor processing control affects efficacy:

[0006] Traditional processing methods, such as wine processing and vinegar processing, involve uncertainties in component transformation, and the content of effective components varies greatly between different batches, making standardization difficult.

[0007] Low efficiency in component extraction and impurity removal:

[0008] Existing processing techniques are insufficient to efficiently remove fat-soluble impurities and heavy metals, while the extraction rate of active ingredients is low, resulting in unstable quality of medicinal materials.

[0009] The drying process results in the loss of active ingredients:

[0010] Traditional hot air drying or baking methods can easily cause the degradation of heat-sensitive components (such as flavonoids and polysaccharides), affecting the efficacy of the medicine.

[0011] In recent years, ultrasonic technology has gained attention in the processing of traditional Chinese medicine. Through cavitation and microfluidic effects, it can accelerate the diffusion of substances, increase the solubility of solutes, and assist in the transformation of components. However, current ultrasonic applications still have drawbacks such as single frequency and fixed processing modes, which cannot meet the needs of different properties of medicinal materials.

[0012] To address the aforementioned problems, this invention provides a method for processing and removing impurities from Chinese medicinal materials by combining ultrasonic treatment. Through multi-frequency ultrasonic action, efficient impurity removal strategies, and intelligent control, the method achieves standardization, automation, and high efficiency in the processing of Chinese medicinal materials. Summary of the Invention

[0013] The purpose of this invention is to overcome the shortcomings of the existing technology and provide a method for processing Chinese medicinal materials and removing impurities by combining ultrasonic treatment.

[0014] To achieve the above objectives, the present invention provides the following technical solution:

[0015] A method for processing and removing impurities from traditional Chinese medicinal materials using ultrasonic treatment, comprising the following steps:

[0016] (S1) Pre-treatment stage: After preliminary sorting of Chinese medicinal materials and removal of visible impurities, the raw materials are placed in an ultrasonic cleaning device and an aqueous solution containing 0.1%-3% biodegradable surfactant is injected. The solution temperature is controlled at 25-50℃, and ultrasonic treatment is started at a frequency of 20-100 kHz and a power density of 0.5-5 W / cm². The treatment time is 10-60 minutes. The circulating filtration system is started simultaneously to remove suspended impurities in real time.

[0017] (S2) Structural Modification Stage: The cleaned Chinese medicinal materials are cut into slices with a thickness of ≤5 mm or granules with a particle size of ≤3 mm, and placed in a closed ultrasonic reactor. A processing excipient solution is added, wherein the excipient includes at least one of wine, vinegar, honey or salt solution, with a concentration range of 5-30% (w / v). Multi-frequency composite ultrasonic treatment is turned on, including alternating low-frequency band (20-40 kHz) and high-frequency band (80-120 kHz). The power of the low-frequency band is 1-3 W / cm², and the power of the high-frequency band is 0.5-2 W / cm². The processing temperature is controlled at 40-80℃, the processing time is 30-180 minutes, and the pressure inside the reactor is adjusted in real time to 0.1-0.5 MPa by a pressure sensor.

[0018] (S3) Deep Impurity Removal Stage: The processed medicinal materials are transferred to a multi-stage ultrasonic extraction device, where they are treated stepwise using polar gradient solvents. First, ultrapure water is used for treatment at 40 kHz ultrasound for 20 minutes. Then, the treatment is switched to an ethanol-water mixed solvent (volume ratio 1:1-4:1) at 80 kHz ultrasound for 30 minutes. Finally, supercritical fluid extraction is used. Heavy metals and fat-soluble impurities were extracted from the fluid under the assistance of 100 kHz ultrasound, with the temperature controlled at 35-60℃ and the pressure at 8-30 MPa.

[0019] (S4) Post-processing stage: The processed medicinal materials are placed in a vacuum freeze-drying system and pre-frozen at -40 to -20℃ for 2-6 hours. Then, they are sublimated and dried under a vacuum of ≤10 Pa. At the same time, 28 kHz ultrasonic vibration is applied to accelerate the migration of moisture, and finally, the finished medicinal materials with a moisture content of ≤8% are obtained.

[0020] Preferably, the ultrasonic cleaning device in step (S1) is equipped with a multi-layer composite transducer array, including planar transducers (operating frequency 40 kHz) and focusing transducers (operating frequency 100 kHz) distributed along the vertical direction, with the power ratio of the two controlled at 1:0.3-1:2; the circulating filtration system includes a three-stage filter with progressively smaller pore size, the first stage being a 200-mesh stainless steel filter, the second stage being a 0.45 μm ceramic filter element, and the third stage being an activated carbon-molecular sieve composite adsorption layer.

[0021] Furthermore, the multi-frequency composite ultrasonic treatment in step (S2) adopts time-division modulation technology, with the duration ratio of the low-frequency band to the high-frequency band being 2.5:1, and the frequency is switched every 5-15 minutes; the amount of the processing excipient solution added is 1.5-5 times the amount of the medicinal material, and the pH value of the solution is dynamically adjusted to 4.5-7.5 by an online pH sensor.

[0022] Furthermore, when the excipient is alcohol, a spirit with an alcohol content of 50-75% vol is selected, and 0.01-0.1% cellulase is added; when the excipient is vinegar, rice vinegar with a total acidity ≥6 g / 100mL is selected, and 0.05-0.3% pectinase is added; during ultrasonic treatment, an infrared spectrometer is used to monitor the conversion rate of the effective components of the medicinal materials in real time, and the treatment is automatically terminated when the content of the target component reaches the preset threshold.

[0023] The supercritical state described in step (S3) In the fluid processing stage, the ultrasonic transducer is integrated into the bottom of the extraction vessel, employing a radially focusing sound field design with a sound pressure level of 0.5-2 MPa; simultaneously... Add 0.1-1% of a chelating agent to the fluid, wherein the chelating agent is a compound of at least two of disodium ethylenediaminetetraacetate, citric acid, or glutathione.

[0024] The vacuum freeze-drying system described in step (S4) is equipped with an ultrasonic vibration plate with a vibration frequency of 28±2kHz and an amplitude of 5-20 μm. The vibration mode is intermittent, with ultrasonic vibration applied for 5-15 minutes every hour of drying. During the drying process, the moisture content of the material is monitored by a dielectric constant sensor, and the ultrasonic-assisted mode is activated when the detected value drops to 12%.

[0025] Furthermore, it also includes quality testing steps, using LC-MS / MS to detect pesticide residues (≤0.01 mg / kg), atomic absorption spectrometry to detect heavy metal content (Pb≤5 ppm, Cd≤0.3 ppm, As≤2 ppm), and microbial limit testing (total aerobic bacteria ≤1000 CFU / g); batches that do not meet the standards are automatically returned to step (S3) for reprocessing.

[0026] Furthermore, the quality inspection step integrates an AI analysis system, which trains historical inspection data through a machine learning model to dynamically optimize the processing parameters of steps (S1)-(S4); when an impurity is detected to exceed the standard, the system automatically generates a parameter adjustment plan, including increasing the ultrasonic treatment time by 5-30%, increasing the solvent concentration by 10-50%, or switching the frequency combination mode.

[0027] This method is applicable to the processing of Chinese medicinal materials including but not limited to root and rhizome (such as ginseng and Panax notoginseng), fruit (such as wolfberry and hawthorn), and mineral (such as gypsum and cinnabar). For mineral medicinal materials, in step (S2), silica microspheres with a particle size ≤100 nm need to be added as ultrasonic energy transfer medium, and the amount added is 0.1-1% of the weight of the medicinal material.

[0028] It includes an ultrasonic cleaning module, a processing reaction module, a supercritical extraction module, and a freeze-drying module connected in series. The modules are connected by an inert gas-protected conveyor belt. The central controller of the system integrates a digital twin model, which can simulate the material status at each processing stage in real time and predict the quality indicators of the final product. When the deviation exceeds 5%, an automatic calibration program is triggered.

[0029] In the above technical solution, the present invention provides a method for processing and removing impurities from traditional Chinese medicinal materials by combining ultrasonic treatment, which has the following beneficial effects:

[0030] (1) Effectively removes impurities and improves the purity of medicinal materials

[0031] Using ultrasonic cleaning (20-100 kHz) combined with biodegradable surfactants and a multi-stage filtration system, it can effectively remove pesticide residues, heavy metals, and microbial contaminants adhering to the surface, through supercritical fluid extraction. The combination of fluid and high-frequency ultrasound (100 kHz) can deeply remove fat-soluble impurities and heavy metals from medicinal materials, ensuring their safety.

[0032] (2) Multi-frequency ultrasonic processing improves the conversion rate of effective components.

[0033] The composite ultrasound of low frequency (20-40 kHz) and high frequency (80-120 kHz) is used to enhance the structural modification of medicinal materials, improve the permeability of processing excipients, and accelerate the conversion of active ingredients. Combined with dynamic pressure control (0.1-0.5 MPa), the Maillard reaction and enzymatic reaction are optimized to improve the bioavailability of active ingredients.

[0034] (3) Intelligent quality control to ensure standardized processing

[0035] An AI analysis system is used, combined with detection methods such as infrared spectroscopy, LC-MS / MS, and atomic absorption spectroscopy, to monitor the processing of medicinal materials in real time, automatically adjust ultrasonic parameters to ensure consistent quality across different batches, predict the quality of the final product through a digital twin model, and perform intelligent calibration to reduce processing errors and improve product consistency.

[0036] (4) Improve drying efficiency and retain medicinal components

[0037] Vacuum freeze drying (≤10 Pa) combined with ultrasonic-assisted dehydration (28 kHz) can reduce the loss of heat-sensitive components (such as flavonoids and polysaccharides) and improve the bioactivity of medicinal materials. By monitoring the moisture content through a dielectric constant sensor, the drying endpoint can be precisely controlled to ensure the storage stability of medicinal materials.

[0038] (5) It has a wide range of applications and is compatible with the processing of various Chinese medicinal materials.

[0039] It is applicable to different types of Chinese medicinal materials, such as rhizomes (ginseng, Panax notoginseng), fruits (goji berries, hawthorn), and minerals (gypsum, cinnabar).

[0040] For mineral-based medicinal materials, additional nano-silica microspheres (≤100 nm) are added to optimize ultrasonic energy transfer and improve processing effects.

[0041] (6) Environmental protection and energy saving, reducing production costs

[0042] The use of ultrasonic-assisted processing reduces the amount of processing auxiliary materials, lowers energy consumption, and improves resource utilization. Combined with a circulating filtration system and inert gas conveying, it reduces wastewater discharge and meets green and environmental protection requirements. Detailed Implementation

[0043] To enable those skilled in the art to better understand the technical solution of the present invention, the present invention will be further described in detail below.

[0044] This invention provides a method for processing and removing impurities from traditional Chinese medicinal materials using ultrasonic treatment, comprising the following steps:

[0045] (S1) Pre-treatment stage: After preliminary sorting of Chinese medicinal materials and removal of visible impurities, the raw materials are placed in an ultrasonic cleaning device and an aqueous solution containing 0.1%-3% biodegradable surfactant is injected. The solution temperature is controlled at 25-50℃, and ultrasonic treatment is started at a frequency of 20-100 kHz and a power density of 0.5-5 W / cm². The treatment time is 10-60 minutes. The circulating filtration system is started simultaneously to remove suspended impurities in real time.

[0046] (S2) Structural Modification Stage: The cleaned Chinese medicinal materials are cut into slices with a thickness of ≤5 mm or granules with a particle size of ≤3 mm, and placed in a closed ultrasonic reactor. A processing excipient solution is added, wherein the excipient includes at least one of wine, vinegar, honey or salt solution, with a concentration range of 5-30% (w / v). Multi-frequency composite ultrasonic treatment is turned on, including alternating low-frequency band (20-40 kHz) and high-frequency band (80-120 kHz). The power of the low-frequency band is 1-3 W / cm², and the power of the high-frequency band is 0.5-2 W / cm². The processing temperature is controlled at 40-80℃, the processing time is 30-180 minutes, and the pressure inside the reactor is adjusted in real time to 0.1-0.5 MPa by a pressure sensor.

[0047] (S3) Deep Impurity Removal Stage: The processed medicinal materials are transferred to a multi-stage ultrasonic extraction device, where they are treated stepwise using polar gradient solvents. First, ultrapure water is used for treatment at 40 kHz ultrasound for 20 minutes. Then, the treatment is switched to an ethanol-water mixed solvent (volume ratio 1:1-4:1) at 80 kHz ultrasound for 30 minutes. Finally, supercritical fluid extraction is used. Heavy metals and fat-soluble impurities were extracted from the fluid under the assistance of 100 kHz ultrasound, with the temperature controlled at 35-60℃ and the pressure at 8-30 MPa.

[0048] (S4) Post-processing stage: The processed medicinal materials are placed in a vacuum freeze-drying system and pre-frozen at -40 to -20℃ for 2-6 hours. Then, they are sublimated and dried under a vacuum of ≤10 Pa. At the same time, 28 kHz ultrasonic vibration is applied to accelerate the migration of moisture, and finally, the finished medicinal materials with a moisture content of ≤8% are obtained.

[0049] In one embodiment of the present invention, the ultrasonic cleaning device in step (S1) is configured with a multi-layer composite transducer array, including planar transducers (operating frequency 40 kHz) and focusing transducers (operating frequency 100 kHz) distributed along the vertical direction, with the power ratio of the two controlled at 1:0.3-1:2; the circulating filtration system includes a three-stage filter with progressively smaller pore size, the first stage being a 200-mesh stainless steel filter screen, the second stage being a 0.45 μm ceramic filter element, and the third stage being an activated carbon-molecular sieve composite adsorption layer.

[0050] Preferably, the multi-frequency composite ultrasonic treatment in step (S2) adopts time-division modulation technology, the duration ratio of the low-frequency band to the high-frequency band is 2.5:1, and the frequency is switched every 5-15 minutes; the amount of the processing excipient solution added is 1.5-5 times the amount of the medicinal material, and the pH value of the solution is dynamically adjusted to 4.5-7.5 by an online pH sensor.

[0051] Preferably, when the excipient is alcohol, a spirit with an alcohol content of 50-75% vol is selected, and 0.01-0.1% cellulase is added; when the excipient is vinegar, rice vinegar with a total acidity ≥6 g / 100mL is selected, and 0.05-0.3% pectinase is added; during ultrasonic treatment, an infrared spectrometer is used to monitor the conversion rate of the effective components of the medicinal materials in real time, and the treatment is automatically terminated when the content of the target component reaches the preset threshold.

[0052] The supercritical state described in step (S3) In the fluid processing stage, the ultrasonic transducer is integrated into the bottom of the extraction vessel, employing a radially focusing sound field design with a sound pressure level of 0.5-2 MPa; simultaneously... Add 0.1-1% of a chelating agent to the fluid, wherein the chelating agent is a compound of at least two of disodium ethylenediaminetetraacetate, citric acid, or glutathione.

[0053] The vacuum freeze-drying system described in step (S4) is equipped with an ultrasonic vibration plate with a vibration frequency of 28±2kHz and an amplitude of 5-20 μm. The vibration mode is intermittent, with ultrasonic vibration applied for 5-15 minutes every hour of drying. During the drying process, the moisture content of the material is monitored by a dielectric constant sensor, and the ultrasonic-assisted mode is activated when the detected value drops to 12%.

[0054] Another embodiment of the present invention includes a quality inspection step, which uses LC-MS / MS to detect pesticide residues (≤0.01 mg / kg), atomic absorption spectrometry to detect heavy metal content (Pb≤5 ppm, Cd≤0.3 ppm, As≤2 ppm), and microbial limit test (total aerobic bacteria ≤1000 CFU / g); batches that do not meet the standards are automatically returned to step (S3) for reprocessing.

[0055] The quality inspection step integrates an AI analysis system, which trains historical inspection data through a machine learning model to dynamically optimize the processing parameters of steps (S1)-(S4). When an impurity is detected to exceed the standard, the system automatically generates a parameter adjustment plan, including increasing the ultrasonic treatment time by 5-30%, increasing the solvent concentration by 10-50%, or switching the frequency combination mode.

[0056] This method is applicable to the processing of Chinese medicinal materials including but not limited to root and rhizome (such as ginseng and Panax notoginseng), fruit (such as wolfberry and hawthorn), and mineral (such as gypsum and cinnabar). For mineral medicinal materials, in step (S2), silica microspheres with a particle size ≤100 nm need to be added as ultrasonic energy transfer medium, and the amount added is 0.1-1% of the weight of the medicinal material.

[0057] It includes an ultrasonic cleaning module, a processing reaction module, a supercritical extraction module, and a freeze-drying module connected in series. The modules are connected by an inert gas-protected conveyor belt. The central controller of the system integrates a digital twin model, which can simulate the material status at each processing stage in real time and predict the quality indicators of the final product. When the deviation exceeds 5%, an automatic calibration program is triggered.

[0058] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A method for processing and removing impurities from traditional Chinese medicinal materials using ultrasonic treatment, characterized in that, Includes the following steps: (S1) Pre-treatment stage: After preliminary sorting of Chinese medicinal materials and removal of visible impurities, the raw materials are placed in an ultrasonic cleaning device and an aqueous solution containing 0.1%-3% biodegradable surfactant is injected. The solution temperature is controlled at 25-50℃, and ultrasonic treatment is started at a frequency of 20-100 kHz and a power density of 0.5-5 W / cm². The treatment time is 10-60 minutes. The circulating filtration system is started simultaneously to remove suspended impurities in real time. (S2) Structural Modification Stage: The cleaned Chinese medicinal materials are cut into slices with a thickness of ≤5 mm or granules with a particle size of ≤3 mm, and placed in a closed ultrasonic reactor. A processing excipient solution is added, wherein the excipient includes at least one of wine, vinegar, honey or salt solution, with a concentration range of 5-30% (w / v). Multi-frequency composite ultrasonic treatment is turned on, including alternating low-frequency band (20-40 kHz) and high-frequency band (80-120 kHz). The power of the low-frequency band is 1-3 W / cm², and the power of the high-frequency band is 0.5-2 W / cm². The processing temperature is controlled at 40-80℃, the processing time is 30-180 minutes, and the pressure inside the reactor is adjusted in real time to 0.1-0.5 MPa by a pressure sensor. (S3) Deep Impurity Removal Stage: The processed medicinal materials are transferred to a multi-stage ultrasonic extraction device, where they are treated stepwise using polar gradient solvents. First, ultrapure water is used for treatment at 40 kHz ultrasound for 20 minutes. Then, the treatment is switched to an ethanol-water mixed solvent (volume ratio 1:1-4:1) at 80 kHz ultrasound for 30 minutes. Finally, supercritical fluid extraction is used. Heavy metals and fat-soluble impurities were extracted from the fluid under the assistance of 100 kHz ultrasound, with the temperature controlled at 35-60℃ and the pressure at 8-30 MPa. (S4) Post-processing stage: The processed medicinal materials are placed in a vacuum freeze-drying system and pre-frozen at -40 to -20℃ for 2-6 hours. Then, they are sublimated and dried under a vacuum of ≤10 Pa. At the same time, 28 kHz ultrasonic vibration is applied to accelerate the migration of moisture, and finally, the finished medicinal materials with a moisture content of ≤8% are obtained.

2. The method for processing and removing impurities from traditional Chinese medicinal materials using ultrasonic treatment as described in claim 1, characterized in that, The ultrasonic cleaning device described in step (S1) is equipped with a multi-layer composite transducer array, including planar transducers (operating frequency 40 kHz) and focusing transducers (operating frequency 100 kHz) distributed along the vertical direction, with the power ratio of the two controlled at 1:0.3-1:2; the circulating filtration system includes a three-stage filter with progressively smaller pore size, the first stage being a 200-mesh stainless steel filter screen, the second stage being a 0.45 μm ceramic filter element, and the third stage being an activated carbon-molecular sieve composite adsorption layer.

3. The method for processing and removing impurities from traditional Chinese medicinal materials using ultrasonic treatment as described in claim 2, characterized in that, The multi-frequency composite ultrasonic treatment in step (S2) adopts time-division modulation technology, with a duration ratio of low frequency band to high frequency band of 2.5:1, and frequency switching is performed every 5-15 minutes; the amount of the processing excipient solution added is 1.5-5 times the amount of medicinal material, and the pH value of the solution is dynamically adjusted to 4.5-7.5 by an online pH sensor.

4. The method for processing and removing impurities from traditional Chinese medicinal materials using ultrasonic treatment as described in claim 1, characterized in that, When the excipient is alcohol, use baijiu with an alcohol content of 50-75% vol and add 0.01-0.1% cellulase; when the excipient is vinegar, use rice vinegar with a total acidity ≥6 g / 100mL and add 0.05-0.3% pectinase; during ultrasonic treatment, use an infrared spectrometer to monitor the conversion rate of the effective components of the medicinal materials in real time, and automatically terminate the treatment when the content of the target component reaches the preset threshold.

5. The method for processing and removing impurities from traditional Chinese medicinal materials using ultrasonic treatment as described in claim 4, characterized in that, The supercritical state described in step (S3) In the fluid processing stage, the ultrasonic transducer is integrated into the bottom of the extraction vessel, employing a radially focusing sound field design with a sound pressure level of 0.5-2 MPa; simultaneously... Add 0.1-1% of a chelating agent to the fluid, wherein the chelating agent is a compound of at least two of disodium ethylenediaminetetraacetate, citric acid, or glutathione.

6. The method for processing and removing impurities from traditional Chinese medicinal materials using ultrasonic treatment as described in claim 1, characterized in that, The vacuum freeze-drying system described in step (S4) is equipped with an ultrasonic vibration plate with a vibration frequency of 28±2 kHz and an amplitude of 5-20 μm. The vibration mode is intermittent, with ultrasonic vibration applied for 5-15 minutes every 1 hour of drying. During the drying process, the moisture content of the material is monitored by a dielectric constant sensor, and the ultrasonic-assisted mode is activated when the detected value drops to 12%.

7. The method for processing and removing impurities from traditional Chinese medicinal materials using ultrasonic treatment as described in claim 1, characterized in that, It also includes quality testing steps, using LC-MS / MS to detect pesticide residues (≤0.01 mg / kg), atomic absorption spectrometry to detect heavy metal content (Pb≤5 ppm, Cd≤0.3 ppm, As≤2 ppm), and microbial limit testing (total aerobic bacteria ≤1000 CFU / g); batches that do not meet the standards are automatically returned to step (S3) for reprocessing.

8. The method for processing and removing impurities of traditional Chinese medicinal materials by combining ultrasonic treatment according to claim 1, characterized in that, The quality inspection step integrates an AI analysis system, which trains historical inspection data through a machine learning model to dynamically optimize the processing parameters of steps (S1)-(S4). When an impurity is detected to exceed the standard, the system automatically generates a parameter adjustment plan, including increasing the ultrasonic treatment time by 5-30%, increasing the solvent concentration by 10-50%, or switching the frequency combination mode.

9. The method for processing and removing impurities from traditional Chinese medicinal materials using ultrasonic treatment as described in claim 1, characterized in that, This method is applicable to the processing of Chinese medicinal materials including but not limited to root and rhizome (such as ginseng and Panax notoginseng), fruit (such as wolfberry and hawthorn), and mineral (such as gypsum and cinnabar). For mineral medicinal materials, in step (S2), silica microspheres with a particle size ≤100 nm need to be added as ultrasonic energy transfer medium, and the amount added is 0.1-1% of the weight of the medicinal material.

10. A method for processing and removing impurities from traditional Chinese medicinal materials using ultrasonic treatment according to claims 1-9, characterized in that, It includes an ultrasonic cleaning module, a processing reaction module, a supercritical extraction module, and a freeze-drying module connected in series. The modules are connected by an inert gas-protected conveyor belt. The central controller of the system integrates a digital twin model, which can simulate the material status at each processing stage in real time and predict the quality indicators of the final product. When the deviation exceeds 5%, an automatic calibration program is triggered.

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