Self-disintegrating transmission

Abstract

The application relates to a self-disintegration transmission device, a shell layer contains the following raw materials in parts by weight, a self-disintegration structure is placed in a disintegration limiting cavity, a sealing push plate is installed at the lower part of the self-disintegration structure, the lower part of the sealing push plate is connected with a limiting cavity cover plate through a spring, a sealing through hole is arranged on one side of a liquid inlet valve, a plugging rod is movably installed in the sealing through hole, and the bottom of the plugging rod is connected with the top of the sealing push plate through a push rod; when the self-disintegration structure disintegrates, the sealing push plate in the limiting state is quickly output under the pressure release action of the spring at the bottom, in the output process, the push rod or a cutting blade or a gate is driven to move upwards, so that the output of the plugging rod, the cutting of a limiting pull rope or the output of the gate are realized, and then the transmission effect is realized.

Description

Technical Field

[0001] This invention relates to the field of medical transmission devices, specifically to a self-disintegrating transmission device. Background Technology

[0002] In medicine, the physical dissolution process of drugs, pharmaceuticals, or mixtures before absorption or action is called disintegration. Currently, common products with disintegration mechanisms on the market include disintegrating tablets, effervescent tablets, multi-layered tablet coatings, and microenvironment-responsive disintegration products. Disintegration is essentially the process of dissolving pills, blocks, tablets, or capsules under specific time, pressure, temperature, or other conditions. Disintegration does not imply absorption but rather a precisely controlled mechanism. With technological advancements, the application of disintegration technology is no longer limited to pharmaceuticals; there is also significant demand in the medical device field. In the field of medical device technology, traditional precise control mechanisms mainly rely on the following methods, all of which have obvious limitations: electronic timing and metering devices require power supplies, are costly, and their reliability is affected by the environment, making them unsuitable for disposable medical devices; manual recording and monitoring methods rely on medical personnel, are easily affected by shift changes, and pose a risk of human error; simple color / scale indicators lack accuracy, are easily overlooked, and lack mandatory replacement / stop mechanisms; mechanical metering systems have difficulty guaranteeing accuracy and cannot adapt to changes in different patient conditions.

[0003] Although there has been research on disintegration mechanisms in the field of drug sustained release, there is still a gap in non-electronic transmission control such as limiting and releasing limits using disintegration mechanisms. Summary of the Invention

[0004] To address the shortcomings of existing technologies, this invention provides a self-disintegrating transmission device that is simple in structure, easy to operate, and based on a self-disintegrating mechanism to achieve limit or release of limit, enabling precise time control of transmission operations such as limit or contact limit, with high working and operating efficiency, adopting non-electronic precise time control to reduce operational risks, and achieving automatic transmission after disintegration, thereby overcoming the deficiencies in existing technologies.

[0005] The technical solution of the present invention is implemented as follows: a self-disintegrating transmission device includes a housing, a disintegration limiting cavity opened in the housing, an inlet valve provided at the top of the disintegration limiting cavity, a self-disintegrating structure placed in the disintegration limiting cavity, a sealing push plate installed at the lower part of the self-disintegrating structure, the lower part of the sealing push plate being connected to the limiting cavity cover plate by a spring, a sealing through hole provided on one side of the inlet valve, a sealing rod movably installed in the sealing through hole, and the bottom of the sealing rod being connected to the top of the sealing push plate by a push rod.

[0006] Furthermore, both the push rod and the sealing rod are cylindrical rod-shaped structures. The diameter of the push rod is not greater than the diameter of the sealing rod. The sealing through hole is a circular through hole structure. The length of the push rod is not less than half the depth of the disintegration limiting cavity. The length of the sealing rod is equal to the depth of the sealing through hole.

[0007] A self-disintegrating transmission device includes a housing and a disintegration limiting cavity formed within the housing. An inlet valve is located at the top of the disintegration limiting cavity. A self-disintegrating structure is placed inside the disintegration limiting cavity. A sealing push plate is installed at the lower part of the self-disintegrating structure. The lower part of the sealing push plate is connected to the limiting cavity cover plate via a spring. A sealing through hole is provided on one side of the inlet valve. A limiting pull rope is fitted inside the sealing through hole. A cutting blade is installed on the top surface of the sealing push plate. The inner end of the limiting pull rope is fixed to the top surface of the disintegration limiting cavity, and a limiting connecting piece is fixedly installed at the outer end of the limiting pull rope.

[0008] Furthermore, a blade limiting groove is provided on the top wall of the disintegration limiting cavity to cooperate with the cutting blade, and a limiting pull rope is set at the bottom opening of the blade limiting groove. A one-way liquid outlet valve is provided on one side of the liquid inlet valve.

[0009] A self-disintegrating transmission device includes a housing and a disintegration limiting cavity formed within the housing. A liquid inlet valve is provided at the top of the disintegration limiting cavity. A self-disintegrating structure is placed inside the disintegration limiting cavity. A sealing push plate is installed at the lower part of the self-disintegrating structure. The lower part of the sealing push plate is connected to the limiting cavity cover plate by a spring. A gate limiting through hole is provided on one side of the liquid inlet valve. A gate is movably installed in the gate limiting through hole. The bottom of the gate is connected to the top of the sealing push plate.

[0010] Furthermore, the gate limiting through hole is a square groove-shaped through hole structure, the inner diameter of the gate limiting through hole matches the outer diameter of the gate, the gate is a square plate-shaped structure, and a one-way outlet valve is provided on one side of the inlet valve.

[0011] Furthermore, a telescopic through hole is provided at the center of the limiting cavity cover plate, and a warning display rod is movably fitted inside the telescopic through hole. The warning display rod is fixedly connected to the bottom of the sealing push plate through a warning telescopic connecting rod, or a telescopic alarm rod is installed on the sealing push plate. A fitting sealing hole is opened on the housing on the side of the liquid inlet valve. The length of the telescopic alarm rod is the sum of the thickness of the self-disintegrating structure and the length of the fitting sealing hole.

[0012] Furthermore, the self-disintegrating structure is composed of a core layer and an outer shell layer surrounding the core layer. The outer shell layer is composed of the following raw materials in parts by weight: 35-40 parts hydroxypropyl methylcellulose, 15-20 parts polyvinyl alcohol, 10-15 parts polyethylene glycol, 25-30 parts microcrystalline cellulose, 9-9.5 parts crosslinking agent, 1-2 parts photoinitiator, and 0.5-1 parts magnesium stearate. The core layer contains the following raw materials in parts by weight: 36 parts hydroxypropyl methylcellulose, 18 parts polyvinyl alcohol, 22 parts microcrystalline cellulose, 7-9 parts pH-sensitive polymer, 4 parts acidic monomer, 1 part magnesium stearate, 3-5 parts buffer, and 7-9 parts temperature compensator.

[0013] Furthermore, the core layer accounts for 40% of the volume, the outer shell layer accounts for 60%, and the self-disintegrating structure is cylindrical, spherical, ellipsoidal, or square blocky. The pH-sensitive polymer is Eudragit, the acidic monomer is fumaric acid, the crosslinking agent is polyethylene glycol diacrylate, the buffer is magnesium hydroxide, and the temperature compensator is β-cyclodextrin. The molecular weight of polyvinyl alcohol in the core layer is 85,000-124,000 Da. The outer shell layer is prepared using a continuous gradient crosslinking technology and includes a surface region, a middle region, and an internal region. The surface region has a hydroxypropyl methylcellulose crosslinking degree of 0.5-1.0%, a polyvinyl alcohol molecular weight of 13000-15000 Da, and a polyethylene glycol content of 15-20%; the middle region has a hydroxypropyl methylcellulose crosslinking degree of 1.0-1.5%, a polyvinyl alcohol molecular weight of 15000-23000 Da, and a polyethylene glycol content of 10-15%; and the internal region has a methylcellulose crosslinking degree of 1.5-2.5%, a polyvinyl alcohol molecular weight of 23000-31000 Da, and a polyethylene glycol content of 5-10%.

[0014] Furthermore, the preparation process of the self-disintegrating structure is as follows: Shell preparation: The above-mentioned parts by weight of hydroxypropyl methylcellulose, polyvinyl alcohol and polyethylene glycol are dissolved in a mixed solvent of water and ethanol, wherein the volume ratio of water to ethanol is 7:3, to form a homogeneous solution. Then, microcrystalline cellulose is added and stirred to form a homogeneous suspension. Finally, crosslinking agent and photoinitiator are added to the suspension. A computer-controlled precision gradient mixing system is used to create a crosslinking agent concentration gradient, with the crosslinking degree on the outer surface being 0.5-1%, linearly increasing to 2.5-4.0% on the inner surface, with a gradient rate of 0.25-0.50% / mm. Core layer preparation: Hydroxypropyl methylcellulose and polyvinyl alcohol are dissolved in a mixed solvent of water and ethanol, wherein the volume ratio of water to ethanol is 1:1. Microcrystalline cellulose, pH-sensitive polymer, acidic monomer and buffer are added. Finally, temperature compensator and magnesium stearate are added and mixed thoroughly. Gradient core-shell structure molding: Using concentric injection molding technology, the core layer material is injected into the center of the mold, and then the outer shell material is injected into the periphery of the mold using a computer-controlled concentration gradient injection system. After irradiation with a UV light source for 15 minutes, a cross-linking gradient is formed. Finally, the structure is vacuum dried at 60°C for 24 hours to obtain a self-disintegrating structure.

[0015] The present invention has the following positive effects: 1. This invention provides a self-disintegrating transmission device, filling the technological gap in achieving precise time / volume control in medical devices using a disintegration mechanism. This product utilizes the installation of a self-disintegrating structure within the disintegration limiting cavity to achieve the limiting operation of the sealing push plate. When the self-disintegrating structure disintegrates, the sealing push plate in the limiting state is rapidly output under the spring pressure release at the bottom. During the output process, it drives the push rod, cutting blade, or gate to move upward, thereby achieving the output of the sealing rod, the cutting of the limiting pull rope, or the output of the gate, thus achieving the transmission effect.

[0016] 2. This invention achieves pre-transmission limiting braking and post-limiting power output through a push rod, limiting rope, or gate plate limiting and output. The push rod is combined with a corresponding rotating device on its outer side to collide with rotating components, thereby displacing external parts. Alternatively, the limiting is released by cutting the limiting rope; or the passage is blocked by the gate plate output. The self-disintegrating structure triggers the elastic output of the spring, making it suitable for various medical applications. In scenarios requiring the blocking of medical tubing, this product can replace traditional electronic transmission, reducing costs and providing a completely new transmission method.

[0017] 3. When the self-disintegrating structure slowly permeates and disintegrates to its internal core, the sealing push plate moves rapidly toward the original position of the self-disintegrating structure under the elastic force of the spring. The inlet valve and the one-way outlet valve work together. When the liquid enters the disintegration limiting cavity through the inlet valve, the outer layer of the self-disintegrating structure controls the water permeation rate to precisely determine the dissolution time. After the water molecules slowly permeate into the interior, they cause the internal filling material to dissolve rapidly, triggering the collapse of the overall structure and achieving the self-disintegration effect. In order to ensure the effective discharge of liquid during product operation, this product is also equipped with a one-way outlet valve for auxiliary liquid discharge according to the specific usage.

[0018] 4. To enhance the practicality of this product during use and provide visual reminders for medical staff, a warning display rod is movably mounted on the limiting cavity cover plate, or a telescopic alarm rod is installed on the sealing push plate. During the transmission process, the warning display rod or the telescopic alarm rod will shift. When the transmission occurs, the warning display rod changes from being exposed outside the housing to being hidden inside the housing; or the telescopic alarm rod changes from being hidden inside the housing to being displayed outside the housing, so as to remind medical staff that the product has been transmitted. Attached Figure Description

[0019] Figure 1 This is one of the schematic diagrams of the internal structure of the present invention.

[0020] Figure 2 For the present invention Figure 1 A schematic diagram of the transmission structure.

[0021] Figure 3 For the present invention Figure 2 A schematic diagram of the three-dimensional structure.

[0022] Figure 4 This is the second schematic diagram of the internal structure of the present invention.

[0023] Figure 5 For the present invention Figure 4 A schematic diagram of the transmission structure.

[0024] Figure 6 For the present invention Figure 5 A schematic diagram of the three-dimensional structure.

[0025] Figure 7 This is the third schematic diagram of the internal structure of the present invention.

[0026] Figure 8 For the present invention Figure 7 A schematic diagram of the transmission structure.

[0027] Figure 9 For the present invention Figure 7 A schematic diagram of the three-dimensional structure.

[0028] Figure 10 This is the fourth schematic diagram of the internal structure of the present invention.

[0029] Figure 11 For the present invention Figure 10 A schematic diagram of the transmission structure.

[0030] Figure 12 For the present invention Figure 11 A schematic diagram of the three-dimensional structure.

[0031] Figure 13This is the fifth schematic diagram of the internal structure of the present invention.

[0032] Figure 14 For the present invention Figure 13 A schematic diagram of the transmission structure.

[0033] Figure 15 For the present invention Figure 14 A schematic diagram of the three-dimensional structure.

[0034] Figure 16 This is the sixth schematic diagram of the internal structure of the present invention.

[0035] Figure 17 For the present invention Figure 16 A schematic diagram of the transmission structure.

[0036] Figure 18 For the present invention Figure 17 A schematic diagram of the three-dimensional structure. Detailed Implementation

[0037] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0038] In the following description of the invention, it should be noted that the terms "upper," "lower," "left," "right," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing the invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation or be constructed and operated in a specific orientation. The term "connection" simply indicates a connection between devices and has no special meaning.

[0039] Example 1: As Figure 1 , 2 As shown in Figure 3, a self-disintegrating transmission device includes a housing 1 and a disintegration limiting cavity 14 opened in the housing 1. A liquid inlet valve 13 is provided at the top of the disintegration limiting cavity 14. A self-disintegrating structure 15 is placed in the disintegration limiting cavity 14. A sealing push plate 20 is installed at the lower part of the self-disintegrating structure 15. The lower part of the sealing push plate 20 is connected to the limiting cavity cover plate 10 through a spring 21. A sealing through hole 17 is provided on one side of the liquid inlet valve 13. A sealing rod 18 is movably installed in the sealing through hole 17. The bottom of the sealing rod 18 is connected to the top of the sealing push plate 20 through a push rod 16.

[0040] Both the push rod 16 and the sealing rod 18 are cylindrical rod-shaped structures. The diameter of the push rod 16 is not greater than the diameter of the sealing rod 18. The sealing through hole 17 is a circular through hole structure. The length of the push rod 16 is not less than half the depth of the disintegration limiting cavity 14, and the length of the sealing rod 18 is equal to the depth of the sealing through hole 17. A telescopic through hole is provided at the center of the limiting cavity cover plate 10. A warning display rod 8 is movably fitted inside the telescopic through hole. The warning display rod 8 is fixedly connected to the bottom of the sealing push plate 20 through a warning telescopic connecting rod 9.

[0041] The self-disintegrating structure 15 is composed of a core layer and an outer shell layer surrounding the core layer. The outer shell layer is composed of the following raw materials in parts by weight: 35-40 parts hydroxypropyl methylcellulose, 15-20 parts polyvinyl alcohol, 10-15 parts polyethylene glycol, 25-30 parts microcrystalline cellulose, 9-9.5 parts crosslinking agent, 1-2 parts photoinitiator, and 0.5-1 parts magnesium stearate. The core layer contains the following raw materials in parts by weight: 36 parts hydroxypropyl methylcellulose, 18 parts polyvinyl alcohol, 22 parts microcrystalline cellulose, 7-9 parts pH-sensitive polymer, 4 parts acidic monomer, 1 part magnesium stearate, 3-5 parts buffer, and 7-9 parts temperature compensator.

[0042] The core layer comprises 40% of the volume, and the outer shell comprises 60%. The self-disintegrating structure 15 is cylindrical, spherical, ellipsoidal, or square blocky. The pH-sensitive polymer is Eudragit, the acidic monomer is fumaric acid, the crosslinking agent is polyethylene glycol diacrylate, the buffer is magnesium hydroxide, and the temperature compensator is β-cyclodextrin. The molecular weight of polyvinyl alcohol in the core layer is 85,000-124,000 Da. The outer shell is prepared using a continuous gradient crosslinking technique and includes a surface region, a middle region, and an internal region. The surface region has a hydroxypropyl methylcellulose crosslinking degree of 0.5-1.0%, a polyvinyl alcohol molecular weight of 13000-15000 Da, and a polyethylene glycol content of 15-20%; the middle region has a hydroxypropyl methylcellulose crosslinking degree of 1.0-1.5%, a polyvinyl alcohol molecular weight of 15000-23000 Da, and a polyethylene glycol content of 10-15%; and the internal region has a methylcellulose crosslinking degree of 1.5-2.5%, a polyvinyl alcohol molecular weight of 23000-31000 Da, and a polyethylene glycol content of 5-10%.

[0043] The preparation process of the self-disintegrating structure 15 is as follows: Shell preparation: The above-mentioned parts by weight of hydroxypropyl methylcellulose, polyvinyl alcohol and polyethylene glycol are dissolved in a mixed solvent of water and ethanol, wherein the volume ratio of water to ethanol is 7:3, to form a homogeneous solution. Then, microcrystalline cellulose is added and stirred to form a homogeneous suspension. Finally, crosslinking agent and photoinitiator are added to the suspension. A computer-controlled precision gradient mixing system is used to create a crosslinking agent concentration gradient, with the crosslinking degree on the outer surface being 0.5-1%, linearly increasing to 2.5-4.0% on the inner surface, with a gradient rate of 0.25-0.50% / mm. Core layer preparation: Hydroxypropyl methylcellulose and polyvinyl alcohol are dissolved in a mixed solvent of water and ethanol, wherein the volume ratio of water to ethanol is 1:1. Microcrystalline cellulose, pH-sensitive polymer, acidic monomer and buffer are added. Finally, temperature compensator and magnesium stearate are added and mixed thoroughly. Gradient core-shell structure molding: Using concentric injection molding technology, the core layer material is injected into the center of the mold, and then the outer shell material is injected into the periphery of the mold using a computer-controlled concentration gradient injection system. After irradiation with a UV light source for 15 minutes, a cross-linking gradient is formed. Finally, the structure is vacuum dried at 60°C for 24 hours to obtain the self-disintegrating structure 15.

[0044] Specifically, the shell 1 is the main structure of this product. The disintegration limiting cavity 14 is divided into two parts: one half is a hollow structure and the other half is for placing the self-disintegrating structure 15. The two parts are isolated by a sealing push plate 20. The self-disintegrating structure 15 adopts a design structure in which the outer shell wraps the core. The outer shell layer controls the water permeation rate, thereby accurately determining the dissolution time. The core layer containing the disintegration triggering mechanism serves as a support to maintain the integrity of the structure. The continuously changing degree of crosslinking creates a diffusion potential energy gradient, so that the permeation of water molecules follows a predictable mathematical model. After the water molecules slowly permeate into the core layer, they trigger the release of acidic monomers, lowering the local pH value. The pH-sensitive polymer dissolves rapidly at a specific pH threshold, triggering the collapse of the overall structure and achieving the self-disintegration effect.

[0045] The sealing push plate 20 and the limiting cavity cover plate 10 are connected by a spring 21. The limiting cavity cover plate 10 is tightly engaged at the bottom of the disintegration limiting cavity groove to achieve a tight seal. After installing the self-disintegrating structure 15, the sealing push plate 20 and the limiting cavity cover plate 10, along with the spring, are installed into the disintegration limiting cavity. The volume of the self-disintegrating structure 15 limits the sealing push plate 20. After limiting, the spring 21 is in a compressed state. At this time, the sealing rod 18 falls into the sealing through hole 17 and is fitted and inserted. The push rod 16 is located in the disintegration limiting cavity 14 on one side of the self-disintegrating structure 15.

[0046] In use, liquid enters the disintegration limiting cavity 14 through the inlet valve 13. The self-disintegrating structure 15 then slowly penetrates the core layer according to a preset disintegration time. When the time or flow rate reaches a preset value, the disintegration system activates its mechanism to achieve instantaneous disintegration. At this point, the self-disintegrating structure 15, which originally supported the sealing push plate 20, loses its supporting function. Under the elastic force of the spring 21, the sealing push plate 20 moves towards the disintegration limiting cavity 14, which originally housed the self-disintegrating structure 15. Simultaneously with the displacement of the sealing push plate 20, the push rod 16 drives the sealing rod 18 out of the sealing through hole 17. The channel between the outer wall of the push rod 16 and the inner wall of the sealing through hole 17 becomes the liquid outlet channel within the disintegration limiting cavity 14. Under the instantaneous disintegration of the self-disintegrating structure 15 and the instantaneous displacement of the sealing push plate 20, the sealing rod 18 is pushed out by the push rod 16, driving the external components of the housing 1.

[0047] During transmission operation, the warning display rod 8, which was originally exposed outside the limit cavity cover plate 10, retracts into the disintegration limit cavity along with the warning telescopic link 9, thereby reminding medical staff that the product has been transmitted.

[0048] Example 2: As Figure 4 , 5 As shown in Figure 6, the difference between this embodiment and Embodiment 1 is that: a telescopic alarm rod 3 is installed on the sealing push plate 20, and a fitting sealing hole 2 is opened on the housing 1 on one side of the liquid inlet valve 13. The length of the telescopic alarm rod 3 is the sum of the thickness of the self-disintegrating structure 15 and the length of the fitting sealing hole 2.

[0049] When in use, during transmission operation, the telescopic alarm rod 3, which was originally fitted inside the sealing hole 2, is output from the sealing hole 2 and exposed on the top of the housing 1 due to the instantaneous displacement of the sealing push plate 20, thereby reminding medical staff that the product has been put into transmission.

[0050] Example 3: As Figure 7 , 8 As shown in Figure 9, a self-disintegrating transmission device includes a housing 1 and a disintegration limiting cavity 14 opened in the housing 1. A liquid inlet valve 13 is provided at the top of the disintegration limiting cavity 14. A self-disintegrating structure 15 is placed in the disintegration limiting cavity 14. A sealing push plate 20 is installed at the lower part of the self-disintegrating structure 15. The lower part of the sealing push plate 20 is connected to the limiting cavity cover plate 10 through a spring 21. A sealing through hole 17 is provided on one side of the liquid inlet valve 13. A limiting pull rope 25 is installed in the sealing through hole 17. A cutting blade 26 is installed on the top surface of the sealing push plate 20. The inner end of the limiting pull rope 25 is fixed to the top surface of the disintegration limiting cavity 14. A limiting connecting piece 4 is fixedly installed at the outer end of the limiting pull rope 25.

[0051] The top wall of the disintegration limiting cavity 14 is provided with a blade limiting groove 24 that mates with the cutting blade 26. A limiting pull rope 25 is set at the bottom opening of the blade limiting groove 24. A one-way discharge valve 27 is provided on one side of the liquid inlet valve 13. A telescopic through hole is provided at the center of the limiting cavity cover plate 10. A warning display rod 8 is movably fitted inside the telescopic through hole. The warning display rod 8 is fixedly connected to the bottom of the sealing push plate 20 through a warning telescopic connecting rod 9.

[0052] The self-disintegrating structure 15 is composed of a core layer and an outer shell layer surrounding the core layer. The outer shell layer is composed of the following raw materials in parts by weight: 35-40 parts hydroxypropyl methylcellulose, 15-20 parts polyvinyl alcohol, 10-15 parts polyethylene glycol, 25-30 parts microcrystalline cellulose, 9-9.5 parts crosslinking agent, 1-2 parts photoinitiator, and 0.5-1 parts magnesium stearate. The core layer contains the following raw materials in parts by weight: 36 parts hydroxypropyl methylcellulose, 18 parts polyvinyl alcohol, 22 parts microcrystalline cellulose, 7-9 parts pH-sensitive polymer, 4 parts acidic monomer, 1 part magnesium stearate, 3-5 parts buffer, and 7-9 parts temperature compensator.

[0053] The core layer comprises 40% of the volume, and the outer shell comprises 60%. The self-disintegrating structure 15 is cylindrical, spherical, ellipsoidal, or square blocky. The pH-sensitive polymer is Eudragit, the acidic monomer is fumaric acid, the crosslinking agent is polyethylene glycol diacrylate, the buffer is magnesium hydroxide, and the temperature compensator is β-cyclodextrin. The molecular weight of polyvinyl alcohol in the core layer is 85,000-124,000 Da. The outer shell is prepared using a continuous gradient crosslinking technique and includes a surface region, a middle region, and an internal region. The surface region has a hydroxypropyl methylcellulose crosslinking degree of 0.5-1.0%, a polyvinyl alcohol molecular weight of 13000-15000 Da, and a polyethylene glycol content of 15-20%; the middle region has a hydroxypropyl methylcellulose crosslinking degree of 1.0-1.5%, a polyvinyl alcohol molecular weight of 15000-23000 Da, and a polyethylene glycol content of 10-15%; and the internal region has a methylcellulose crosslinking degree of 1.5-2.5%, a polyvinyl alcohol molecular weight of 23000-31000 Da, and a polyethylene glycol content of 5-10%.

[0054] The preparation process of the self-disintegrating structure 15 is as follows: Shell preparation: The above-mentioned parts by weight of hydroxypropyl methylcellulose, polyvinyl alcohol and polyethylene glycol are dissolved in a mixed solvent of water and ethanol, wherein the volume ratio of water to ethanol is 7:3, to form a homogeneous solution. Then, microcrystalline cellulose is added and stirred to form a homogeneous suspension. Finally, crosslinking agent and photoinitiator are added to the suspension. A computer-controlled precision gradient mixing system is used to create a crosslinking agent concentration gradient, with the crosslinking degree on the outer surface being 0.5-1%, linearly increasing to 2.5-4.0% on the inner surface, with a gradient rate of 0.25-0.50% / mm. Core layer preparation: Hydroxypropyl methylcellulose and polyvinyl alcohol are dissolved in a mixed solvent of water and ethanol, wherein the volume ratio of water to ethanol is 1:1. Microcrystalline cellulose, pH-sensitive polymer, acidic monomer and buffer are added. Finally, temperature compensator and magnesium stearate are added and mixed thoroughly. Gradient core-shell structure molding: Using concentric injection molding technology, the core layer material is injected into the center of the mold, and then the outer shell material is injected into the periphery of the mold using a computer-controlled concentration gradient injection system. After irradiation with a UV light source for 15 minutes, a cross-linking gradient is formed. Finally, the structure is vacuum dried at 60°C for 24 hours to obtain the self-disintegrating structure 15.

[0055] In use, liquid enters the disintegration limiting chamber 14 through the inlet valve 13. The self-disintegrating structure 15 then slowly penetrates the core layer according to a preset disintegration time. When the time or flow rate reaches a preset value, the disintegration system activates its mechanism to achieve instantaneous disintegration. At this point, the self-disintegrating structure 15, which originally supported the sealing push plate 20, loses its supporting function. Under the elastic force of the spring 21, the sealing push plate 20 moves towards the disintegration limiting chamber 14, which originally housed the self-disintegrating structure 15. Simultaneously with the displacement of the sealing push plate 20, the cutting blade 26 moves towards the blade limiting groove 24. When it touches the taut limiting rope 25 under pressure, the limiting rope 25 is cut, the limiting connecting piece 4 is released from restriction, and the external components connected to the limiting connecting piece 4 are released from restriction.

[0056] During transmission operation, the warning display rod 8, which was originally exposed on the outside of the limit cavity cover plate 10, retracts into the disintegration limit cavity along with the warning telescopic link 9, thereby reminding medical staff that the product has entered the transmission state.

[0057] Example 4: Figure 10 , 11 As shown in Figure 12, the difference between this embodiment and embodiment 3 is that a telescopic alarm rod 3 is installed on the sealing push plate 20, and a fitting sealing hole 2 is opened on the housing 1 on one side of the liquid inlet valve 13. The length of the telescopic alarm rod 3 is the sum of the thickness of the self-disintegrating structure 15 and the length of the fitting sealing hole 2.

[0058] When in use, during transmission operation, the telescopic alarm rod 3, which was originally fitted inside the sealing hole 2, is output from the sealing hole 2 and exposed on the top of the housing 1 due to the instantaneous displacement of the sealing push plate 20, thereby reminding medical staff that the product has been put into transmission.

[0059] Example 5: Figure 13 , 14 As shown in Figure 15, a self-disintegrating transmission device includes a housing 1 and a disintegration limiting cavity 14 opened in the housing 1. A liquid inlet valve 13 is provided at the top of the disintegration limiting cavity 14. A self-disintegrating structure 15 is placed in the disintegration limiting cavity 14. A sealing push plate 20 is installed at the lower part of the self-disintegrating structure 15. The lower part of the sealing push plate 20 is connected to the limiting cavity cover plate 10 through a spring 21. A gate limiting through hole 28 is provided on one side of the liquid inlet valve 13. A gate plate 5 is movably installed in the gate limiting through hole 28. The bottom of the gate plate 5 is connected to the top of the sealing push plate 20.

[0060] The gate limiting through hole 28 is a square groove-shaped through hole structure. The inner diameter of the gate limiting through hole 28 matches the outer diameter of the gate 5. The gate 5 is a square plate-shaped structure. A one-way outlet valve 27 is provided on one side of the inlet valve 13. A telescopic through hole is provided at the center of the limiting cavity cover plate 10. A warning display rod 8 is movably fitted inside the telescopic through hole. The warning display rod 8 is fixedly connected to the bottom of the sealing push plate 20 through a warning telescopic connecting rod 9.

[0061] The self-disintegrating structure 15 is composed of a core layer and an outer shell layer surrounding the core layer. The outer shell layer is composed of the following raw materials in parts by weight: 35-40 parts hydroxypropyl methylcellulose, 15-20 parts polyvinyl alcohol, 10-15 parts polyethylene glycol, 25-30 parts microcrystalline cellulose, 9-9.5 parts crosslinking agent, 1-2 parts photoinitiator, and 0.5-1 parts magnesium stearate. The core layer contains the following raw materials in parts by weight: 36 parts hydroxypropyl methylcellulose, 18 parts polyvinyl alcohol, 22 parts microcrystalline cellulose, 7-9 parts pH-sensitive polymer, 4 parts acidic monomer, 1 part magnesium stearate, 3-5 parts buffer, and 7-9 parts temperature compensator.

[0062] The core layer comprises 40% of the volume, and the outer shell comprises 60%. The self-disintegrating structure 15 is cylindrical, spherical, ellipsoidal, or square blocky. The pH-sensitive polymer is Eudragit, the acidic monomer is fumaric acid, the crosslinking agent is polyethylene glycol diacrylate, the buffer is magnesium hydroxide, and the temperature compensator is β-cyclodextrin. The molecular weight of polyvinyl alcohol in the core layer is 85,000-124,000 Da. The outer shell is prepared using a continuous gradient crosslinking technique and includes a surface region, a middle region, and an internal region. The surface region has a hydroxypropyl methylcellulose crosslinking degree of 0.5-1.0%, a polyvinyl alcohol molecular weight of 13000-15000 Da, and a polyethylene glycol content of 15-20%; the middle region has a hydroxypropyl methylcellulose crosslinking degree of 1.0-1.5%, a polyvinyl alcohol molecular weight of 15000-23000 Da, and a polyethylene glycol content of 10-15%; and the internal region has a methylcellulose crosslinking degree of 1.5-2.5%, a polyvinyl alcohol molecular weight of 23000-31000 Da, and a polyethylene glycol content of 5-10%.

[0063] The preparation process of the self-disintegrating structure 15 is as follows: Shell preparation: The above-mentioned parts by weight of hydroxypropyl methylcellulose, polyvinyl alcohol and polyethylene glycol are dissolved in a mixed solvent of water and ethanol, wherein the volume ratio of water to ethanol is 7:3, to form a homogeneous solution. Then, microcrystalline cellulose is added and stirred to form a homogeneous suspension. Finally, crosslinking agent and photoinitiator are added to the suspension. A computer-controlled precision gradient mixing system is used to create a crosslinking agent concentration gradient, with the crosslinking degree on the outer surface being 0.5-1%, linearly increasing to 2.5-4.0% on the inner surface, with a gradient rate of 0.25-0.50% / mm. Core layer preparation: Hydroxypropyl methylcellulose and polyvinyl alcohol are dissolved in a mixed solvent of water and ethanol, wherein the volume ratio of water to ethanol is 1:1. Microcrystalline cellulose, pH-sensitive polymer, acidic monomer and buffer are added. Finally, temperature compensator and magnesium stearate are added and mixed thoroughly. Gradient core-shell structure molding: Using concentric injection molding technology, the core layer material is injected into the center of the mold, and then the outer shell material is injected into the periphery of the mold using a computer-controlled concentration gradient injection system. After irradiation with a UV light source for 15 minutes, a cross-linking gradient is formed. Finally, the structure is vacuum dried at 60°C for 24 hours to obtain the self-disintegrating structure 15.

[0064] In use, liquid enters the disintegration limiting cavity 14 through the inlet valve 13. The self-disintegrating structure 15 then slowly penetrates the core layer according to a preset disintegration time. When the time or flow rate reaches a preset value, the disintegration system activates its mechanism to achieve instantaneous disintegration. At this point, the self-disintegrating structure 15, which originally supported the sealing push plate 20, loses its supporting function. Under the elastic force of the spring 21, the sealing push plate 20 moves towards the disintegration limiting cavity 14, which originally housed the self-disintegrating structure 15. Simultaneously with the displacement of the sealing push plate 20, the gate 5 moves out of the gate limiting through hole 28, thus initiating transmission.

[0065] During transmission operation, the warning display rod 8, which was originally exposed on the outside of the limiting cavity cover plate 10, retracts into the disintegration limiting cavity along with the warning telescopic link 9, thereby reminding medical staff that the product has been activated.

[0066] Example 6: As Figure 16 , 17 As shown in Figure 18, the difference between this embodiment and embodiment 5 is that a telescopic alarm rod 3 is installed on the sealing push plate 20, and a fitting sealing hole 2 is opened on the housing 1 on one side of the liquid inlet valve 13. The length of the telescopic alarm rod 3 is the sum of the thickness of the self-disintegrating structure 15 and the length of the fitting sealing hole 2.

[0067] When in use, during transmission operation, the telescopic alarm rod 3, which was originally fitted inside the sealing hole 2, is output from the sealing hole 2 and exposed on the top of the housing 1 due to the instantaneous displacement of the sealing push plate 20, thereby reminding medical staff that the product has been put into transmission.

[0068] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A self-disintegrating transmission device, comprising a housing (1) and a disintegration limiting cavity (14) formed within the housing (1), characterized in that: The top of the disintegration limiting cavity (14) is provided with an inlet valve (13), and a self-disintegrating structure (15) is placed inside the disintegration limiting cavity (14). A sealing push plate (20) is installed at the lower part of the self-disintegrating structure (15). The lower part of the sealing push plate (20) is connected to the limiting cavity cover plate (10) through a spring (21). A sealing through hole (17) is provided on one side of the inlet valve (13). A sealing rod (18) is movably installed inside the sealing through hole (17). The bottom of the sealing rod (18) is connected to the top of the sealing push plate (20) through a push rod (16).

2. The self-disintegrating transmission device according to claim 1, characterized in that: Both the push rod (16) and the sealing rod (18) are cylindrical rod-shaped structures. The diameter of the push rod (16) is not greater than the diameter of the sealing rod (18). The sealing through hole (17) is a circular through hole structure. The length of the push rod (16) is not less than half the depth of the disintegration limiting cavity (14). The length of the sealing rod (18) is equal to the depth of the sealing through hole (17).

3. A self-disintegrating transmission device, comprising a housing (1) and a disintegration limiting cavity (14) formed within the housing (1), characterized in that: The top of the disintegration limiting cavity (14) is provided with an inlet valve (13), and a self-disintegrating structure (15) is placed inside the disintegration limiting cavity (14). A sealing push plate (20) is installed at the lower part of the self-disintegrating structure (15). The lower part of the sealing push plate (20) is connected to the limiting cavity cover plate (10) by a spring (21). A sealing through hole (17) is provided on one side of the inlet valve (13). A limiting pull rope (25) is fitted inside the sealing through hole (17). A cutting blade (26) is installed on the top surface of the sealing push plate (20). The inner end of the limiting pull rope (25) is fixed to the top surface of the disintegration limiting cavity (14), and a limiting connecting piece (4) is fixedly installed on the outer end of the limiting pull rope (25).

4. The self-disintegrating transmission device according to claim 3, characterized in that: The top wall of the disintegration limiting cavity (14) is provided with a blade limiting groove (24) that cooperates with the cutting blade (26). The limiting pull rope (25) is set at the bottom opening of the blade limiting groove (24). A one-way discharge valve (27) is provided on one side of the liquid inlet valve (13).

5. A self-disintegrating transmission device, comprising a housing (1) and a disintegration limiting cavity (14) formed within the housing (1), characterized in that: The top of the disintegration limiting cavity (14) is provided with an inlet valve (13), and a self-disintegrating structure (15) is placed inside the disintegration limiting cavity (14). A sealing push plate (20) is installed at the lower part of the self-disintegrating structure (15). The lower part of the sealing push plate (20) is connected to the limiting cavity cover plate (10) through a spring (21). A gate limiting through hole (28) is provided on one side of the inlet valve (13). A gate plate (5) is movably installed inside the gate limiting through hole (28). The bottom of the gate plate (5) is connected to the top of the sealing push plate (20).

6. The self-disintegrating transmission device according to claim 5, characterized in that: The gate limiting through hole (28) is a square groove through hole structure. The inner diameter of the gate limiting through hole (28) matches the outer diameter of the gate (29). The gate (28) is a square plate structure. A one-way outlet valve (27) is provided on one side of the liquid inlet valve (13).

7. The self-disintegrating transmission device according to claim 1, 3, or 5, characterized in that: The center of the limiting cavity cover plate (10) is provided with a telescopic through hole, and a warning display rod (8) is movably fitted inside the telescopic through hole. The warning display rod (8) is fixedly connected to the bottom of the sealing push plate (20) through the warning telescopic connecting rod (9). Alternatively, a telescopic alarm rod (3) is installed on the sealing push plate (20). A fitting sealing hole (2) is opened on the housing (1) on the side of the liquid inlet valve (13). The length of the telescopic alarm rod (3) is the sum of the thickness of the self-disintegrating structure (15) and the length of the fitting sealing hole (2).

8. The self-disintegrating transmission device according to claim 1, 3, or 5, characterized in that: The self-disintegrating structure (15) is composed of a core layer and an outer shell layer surrounding the core layer. The outer shell layer is composed of the following raw materials in parts by weight: 35-40 parts of hydroxypropyl methylcellulose, 15-20 parts of polyvinyl alcohol, 10-15 parts of polyethylene glycol, 25-30 parts of microcrystalline cellulose, 9-9.5 parts of crosslinking agent, 1-2 parts of photoinitiator, and 0.5-1 parts of magnesium stearate. The core layer contains the following raw materials in parts by weight: 36 parts of hydroxypropyl methylcellulose, 18 parts of polyvinyl alcohol, 22 parts of microcrystalline cellulose, 7-9 parts of pH-sensitive polymer, 4 parts of acidic monomer, 1 part of magnesium stearate, 3-5 parts of buffer, and 7-9 parts of temperature compensator.

9. The self-disintegrating transmission device according to claim 8, characterized in that: The core layer has a volume of 40%, the outer shell has a volume of 60%, and the self-disintegrating structure (15) is cylindrical, spherical, ellipsoidal or square block structure. The pH-sensitive polymer is Eudragit, the acidic monomer is fumaric acid, the crosslinking agent is polyethylene glycol diacrylate, the buffer is magnesium hydroxide, and the temperature compensation agent is β-cyclodextrin. The molecular weight of polyvinyl alcohol in the core layer is 85,000-124,000 Da. The outer shell is prepared by continuous gradient crosslinking technology. The outer shell includes a surface area, a middle area and an internal area. The degree of crosslinking of hydroxypropyl methylcellulose in the surface area is 0.5-1.0%, the molecular weight of polyvinyl alcohol is 13,000-15,000 Da, and the content of polyethylene glycol is 15-20%. The intermediate region has a hydroxypropyl methylcellulose crosslinking degree of 1.0-1.5%, a polyvinyl alcohol molecular weight of 15000-23000 Da, and a polyethylene glycol content of 10-15%; the internal region has a methylcellulose crosslinking degree of 1.5-2.5%, a polyvinyl alcohol molecular weight of 23000-31000 Da, and a polyethylene glycol content of 5-10%.

10. The self-disintegrating transmission device according to claim 8, characterized in that: The preparation process of the self-disintegrating structure (15) is as follows: Shell preparation: The above-mentioned parts by weight of hydroxypropyl methylcellulose, polyvinyl alcohol and polyethylene glycol are dissolved in a mixed solvent of water and ethanol, wherein the volume ratio of water to ethanol is 7:3, to form a homogeneous solution. Then, microcrystalline cellulose is added and stirred to form a homogeneous suspension. Finally, crosslinking agent and photoinitiator are added to the suspension. A computer-controlled precision gradient mixing system is used to create a crosslinking agent concentration gradient, with the crosslinking degree on the outer surface being 0.5-1%, linearly increasing to 2.5-4.0% on the inner surface, with a gradient rate of 0.25-0.50% / mm. Core layer preparation: Hydroxypropyl methylcellulose and polyvinyl alcohol are dissolved in a mixed solvent of water and ethanol, wherein the volume ratio of water to ethanol is 1:

1. Microcrystalline cellulose, pH-sensitive polymer, acidic monomer and buffer are added. Finally, temperature compensator and magnesium stearate are added and mixed thoroughly. Gradient core-shell structure molding: Using concentric injection molding technology, the core layer material is injected into the center of the mold, and then the outer shell material is injected into the periphery of the mold using a computer-controlled concentration gradient injection system. After irradiation with a UV light source for 15 minutes, a cross-linking gradient is formed. Finally, the structure is vacuum dried at 60°C for 24 hours to obtain a self-disintegrating structure (15).

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