Biosafety integrated detection system

Abstract

The application belongs to the technical field of biological detection, and specifically discloses a biological safety integrated detection system, which comprises the following modules: an intelligent card reading module for detecting harmful substances in a to-be-detected object and giving a property judgment; a full-automatic nucleic acid analysis module for detecting pathogens, pathogenic microorganisms and identifying species in the to-be-detected object; a portable mass spectrum module for performing mass spectrum analysis and detection on compounds in the to-be-detected object and analyzing the content and molecular structure of the to-be-detected object; a chemical sensor module for determining the type of a to-be-detected gas through an algorithm; an enhanced Raman module for identifying the chemical components of unknown substances; a code spraying and reading module for spraying a code on an evidence bag of the to-be-detected object and uploading the code to a mobile terminal module through scanning; and the mobile terminal module for tracing and controlling the to-be-detected object, assisting in detection, obtaining a detection result and comprehensively analyzing and judging. The scheme solves the technical problem of weak detection capacity of traditional toxic substance detection which relies on a laboratory.

Description

Technical Field

[0001] This invention belongs to the technical field of biological detection, specifically relating to an integrated biosafety detection system. Background Technology

[0002] In today's era of deepening globalization and rapid technological advancement, the scope of national security has become increasingly broad and complex, with biosecurity, as a key component, playing an increasingly prominent role. Biosecurity is not only related to public health and life, but also closely linked to national stability, economic development, and international image. Since the 21st century, biological warfare and bioterrorism incidents have occurred frequently worldwide. These incidents are often sudden, highly dangerous, and unpredictable, causing enormous disasters and losses to human society. At the same time, with the continuous innovation of biotechnology, the potential risks of dual-use biotechnologies have increased significantly. These intertwined factors have dramatically increased the complexity and uncertainty of the global biosecurity situation, posing unprecedented challenges to the biosecurity prevention and control capabilities of various countries.

[0003] Currently, my country has established a relatively complete traditional detection technology system in the field of biosafety control. This system has played an important role in responding to past biosafety incidents, accumulating considerable experience in areas such as infectious disease outbreak monitoring and food safety testing. From a technical perspective, traditional detection technologies mainly rely on various sophisticated instruments and complex operating procedures in a laboratory environment. For example, in virus detection, polymerase chain reaction (PCR) technology is commonly used, which amplifies viral nucleic acids using specific primers to detect viruses; in bacterial detection, culture methods are commonly used, identifying bacteria by inoculating samples onto specific culture media and observing bacterial growth. However, these traditional detection technologies also have many limitations in practical applications.

[0004] Traditional detection technologies suffer from a series of significant technical bottlenecks, severely restricting my country's response efficiency to biosecurity threats. First, limited testing scenarios are a prominent issue. Traditional detection relies heavily on the laboratory environment; the entire process, from sample collection and transportation to laboratory testing, is time-consuming and places extremely high demands on laboratory facilities, equipment, and personnel. This not only results in slow testing speeds, making it difficult to meet the rapid response needs of sudden biosecurity incidents. Second, multi-target detection capabilities are weak. A single technology platform can only cover a maximum of 3-5 types of biosecurity threats. Faced with a complex and ever-changing biosecurity situation, it is difficult to comprehensively and accurately identify various potential biosecurity threats, increasing the risk of missed and false detections. Summary of the Invention

[0005] The purpose of this invention is to provide an integrated biosafety detection system to solve the technical problems of traditional biological detection relying on laboratories and having weak detection capabilities.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: An integrated biosafety detection system includes: a smart card reader module, a fully automated nucleic acid analysis module, a portable mass spectrometry module, a chemical sensor module, an enhanced Raman spectroscopy module, a coding and reading module, and a mobile terminal module. The smart card reader module is used to detect harmful substances in the analyte and provide a property assessment. The fully automated nucleic acid analysis module is used for pathogen detection, pathogenic microorganism detection, and species identification in the analyte. The portable mass spectrometry module is used for mass spectrometry analysis of compounds in the analyte, and for analyzing the analyte's content and molecular structure. The chemical sensor module is used to determine the type of gas to be tested using an algorithm. The enhanced Raman spectroscopy module is used to identify the chemical composition of unknown substances. The coding and reading module is used to code the analyte's evidence bag and scan the code to upload it to the mobile terminal module. The mobile terminal module is used for analyte traceability and control, auxiliary detection, acquisition of detection results, and comprehensive analysis and judgment.

[0007] In this invention, by integrating nucleic acid detection technology, immunoassay technology, mass spectrometry analysis technology, Raman analysis technology, sensor analysis technology, and intelligent data analysis technology, a portable on-site rapid detection system is formed, which enables rapid screening and accurate identification of toxins and drugs. This realizes the on-site and real-time analysis of the integrated biosafety detection system, solving the technical problems of traditional toxin detection relying on laboratories and having weak detection capabilities, and achieving the technical effect of rapid on-site detection of biological samples. Attached Figure Description

[0008] Figure 1 This is a schematic diagram of the structure of an integrated biosafety detection system according to an embodiment of the present invention.

[0009] Figure 2 This is a schematic diagram of the detection process of an integrated biosafety detection system under the food safety environment of a major event, according to an embodiment of the present invention.

[0010] Figure 3 This is a schematic diagram of the detection process under the food safety traceability environment of an integrated biosafety detection system according to an embodiment of the present invention. Detailed Implementation

[0011] The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments. The advantages and features of the present invention will become clearer from the following description and claims. It should be noted that the drawings are all in a very simplified form and are not to a precise scale, and are only used to facilitate and clarify the illustration of the embodiments of the present invention.

[0012] It should be noted that, in order to clearly illustrate the content of this invention, several embodiments are provided to further explain different implementations of the invention. These embodiments are enumerated rather than exhaustive. Furthermore, for the sake of brevity, content mentioned in the preceding embodiments is often omitted in the following embodiments. Therefore, content not mentioned in the later embodiments can be referred to in the preceding embodiments.

[0013] Example 1 An integrated biosafety detection system, such as Figure 1 As shown, the system includes: a smart card reader module, a fully automated nucleic acid analysis module, a portable mass spectrometry module, a chemical sensor module, an enhanced Raman spectroscopy module, a coding and reading module, and a mobile terminal module; The intelligent card reader module is used to detect harmful substances in the test object and provide a property judgment; The fully automated nucleic acid analysis module is used for pathogen detection, pathogenic microorganism detection, and species identification in analytes; The portable mass spectrometry module is used to perform mass spectrometry analysis and detection of compounds in the analyte, and to analyze the content and molecular structure of the analyte; The chemical sensor module is used to determine the type of gas to be tested using algorithms; Enhanced Raman modules are used to identify the chemical composition of unknown substances; The coding and scanning module is used to spray codes onto the evidence bags of the test objects and scan the codes to upload them to the mobile terminal module; The mobile terminal module is used for tracing and controlling the test object, assisting in detection and obtaining test results, and comprehensive analysis and judgment.

[0014] As an optional implementation, the smart card reader module is a colloidal gold card / fluorescent card smart card reader module, and supports simultaneous reading of multiple cards.

[0015] As an optional implementation method, the smart card reader module calculates the concentration of various harmful substances in the substance to be tested and gives a negative or positive result. Harmful substances include pesticide residues, veterinary drug residues, heavy metal residues, illegal additives, and fungal toxins.

[0016] Optionally, the colloidal gold card / fluorescent card smart reader module is not limited to the rapid detection of various harmful substances in edible agricultural products and processed foods. Specifically, it includes, but is not limited to, pesticide residues such as carbofuran, acetamiprid, and chlorothalonil; veterinary drug residues such as clenbuterol hydrochloride and ractopamine; heavy metal residues such as lead and mercury; illegal additives such as potassium sorbate and sodium benzoate; and mycotoxins such as aflatoxin M1 and vomitoxin.

[0017] Specifically, it is not limited to using the RAIV-210Y model, which has one detection channel and a data storage capacity of more than 100,000 sample records.

[0018] The specific testing steps are not limited to: on-site sample collection → sample pretreatment → dropping the extract onto the test card → device / mobile app reading the card → result display.

[0019] The colloidal gold / fluorescent card smart reader module can read multiple cards simultaneously, supporting 1-9 cards at once, improving testing efficiency and supporting multi-product testing. It also enables data networking, linking with a cloud platform to support data storage, uploading, and retrieval, facilitating data management and analysis. Furthermore, it can display results, automatically calculating concentration and providing negative / positive results; and card reading can be performed anytime, anywhere simply by installing a mobile app or using the system's built-in mobile terminal module.

[0020] As an optional implementation, the fully automated nucleic acid analysis module obtains the test results of the analyte by inserting a sampled swab into the test box.

[0021] Optionally, the fully automated nucleic acid analysis module is used for pathogen identification and species identification, and is suitable for infection detection, environmental risk monitoring, food safety, and border control. The testing scope includes, but is not limited to: respiratory pathogen detection, gastrointestinal pathogen detection, foodborne pathogen detection, and species identification (meat-derived identification).

[0022] Specifically, the fully automated nucleic acid analysis module is not limited to using the FlashNano / single-throughput model, and the detection steps are not limited to: swab sampling → swab directly inserted into the test kit → machine loading → results returned to the mobile terminal.

[0023] The fully automated nucleic acid analysis module is compact and portable, suitable for on-site rapid testing. It is simple to operate, fast in speed, and can achieve sample input and result output within 20 minutes. The test results are highly sensitive, and the results are automatically analyzed and judged. The matching reagents can be transported at room temperature. It adopts a fully enclosed design, with no risk of contamination, and ensures biosafety.

[0024] As an alternative implementation method, the portable mass spectrometry module uses in-situ direct ionization of compounds in the analyte for mass spectrometry analysis and detection, and resolves trace components in complex mixtures through multi-stage tandem mass spectrometry.

[0025] As an alternative implementation, the portable mass spectrometry module can perform single or combined detection of targets and detect multiple targets in complex mixtures.

[0026] Optionally, the portable mass spectrometry module is not limited to mass spectrometry analysis of volatile, non-volatile, thermally stable, or thermally unstable compounds, thereby enabling the analysis of the content and molecular structure of the analyte. Scope of testing: Including but not limited to substances such as poisons, narcotics, new psychoactive substances, precursor chemicals, illegal additives, and explosives. Through rapid on-site detection and analysis, it can be applied to various scenarios such as security for large-scale events, food safety testing, poison screening, and drug enforcement, achieving rapid, sensitive, and accurate on-site detection and analysis.

[0027] Specifically, not limited to using the P3001 model, the specific detection steps include: taking about 1g of sample (solid samples need to be chopped) and placing it in a 10mL centrifuge tube → adding 4mL of acetonitrile, shaking for 1min, and allowing it to stand for 3mins after thorough mixing → using a pipette to transfer 100 μl of supernatant to the back window of the PCS kit.

[0028] Portable mass spectrometry modules are not limited to in-situ direct ionization technology, requiring no complex pretreatment steps and enabling sample input and result output within 10 minutes. The integrated main unit design is portable and mobile, environmentally adaptable, and suitable for complex environments, allowing for instrument setup and calibration within 10 minutes. One-click calibration and detection are also supported. Utilizing multi-stage tandem mass spectrometry (MS / MS)... n This technology can resolve trace components (ppb level) in complex mixtures; at the same time, it covers a wide range of targets and supports single or combined detection of targets; it supports the detection of multiple targets in complex mixtures.

[0029] As an alternative implementation, the chemical sensor module employs a high-dimensional sensor array, combined with artificial intelligence algorithms, to distinguish and identify different types of gases.

[0030] As an alternative implementation, the chemical sensor module bio-high-dimensional sensor array includes 80 miniaturized MEMS sensors.

[0031] Optionally, the chemical sensor module is not limited to the analysis of toxic and harmful gases or complex odors, such as human body odor, and can be combined with algorithms to determine the types of toxic and harmful gases. The detected gases include, but are not limited to: volatile organic compounds, including ketones (acetone, etc.), aldehydes (formaldehyde, acetaldehyde, etc.), alcohols (methanol, ethanol, n-butanol, isopropanol, etc.), aromatic compounds (benzene, o- / p- / m-xylene), and acids (ethyl acetate); toxic and harmful gases: hydrogen sulfide, carbon monoxide, methane, etc.

[0032] The testing scope is not limited to the following: VOCs: ≥0.5ppm, with the detection limit of acetone being 0.02ppb; Toxic and harmful gases: hydrogen sulfide ≥0.2ppm, carbon monoxide ≥0.5ppm, methane ≥0.5ppm; the detection limit for some gases is 0.01ppm.

[0033] Specifically, the chemical sensor module uses the XJ-Sens1 model. The detection steps are as follows: turn on the power, allow the machine to warm up for 10 minutes, turn on the gas sampling device software and hardware, monitor toxic gases in the air in real time, blow air into the instrument to detect respiratory diseases, and place the instrument within 0.5m of the person being tested. It can also detect bodily fluids, urine, sweat, etc., from the person being tested to identify corresponding diseases.

[0034] The chemical sensor module employs a high-dimensional sensor array, incorporating 80 miniaturized MEMS sensors and combining them with artificial intelligence algorithms to distinguish between different types of complex gases. Previously, the most widely reported electronic noses internationally were 72-dimensional sensor arrays, but this product significantly surpasses similar international products in terms of sensor quantity, detection types, and detection limits. Furthermore, the chemical sensor module uses Ethernet for data transmission, providing local and online monitoring capabilities. The upgraded software supports customized local algorithms for identification functions, emphasizing independent scientific research and exploration.

[0035] As an alternative implementation, the enhanced Raman module identifies the chemical composition of unknown substances by adding an enhancing reagent to the sample.

[0036] Optionally, the aforementioned enhanced Raman module can quickly identify the chemical composition of unknown substances, such as organic matter, inorganic matter, drugs, explosives, and narcotics. The scope of testing is not limited to the detection of substances that endanger public safety, including narcotics and precursor chemicals, hazardous chemicals, explosives and precursor chemicals.

[0037] The enhanced Raman module is not limited to the handheld enhanced Raman BR-410, but also includes a surface scanner and microscope lens, with a wavelength range of 200-3200cm. The detection steps are not limited to: powering on → adjusting the focus according to the sample → directly clicking to detect / taking 1 ml of sample → sample pretreatment → adding the enhancer → detection.

[0038] The enhanced Raman module achieves a resolution of 6-8 cm⁻¹, providing stronger identification and analysis capabilities; the maximum drift is 0-2 cm⁻¹; it can detect up to 4 substances in solid mixtures and up to 5 substances in liquid mixtures; it uses enhancing reagents to avoid interference from high fluorescence, while simultaneously detecting trace amounts of narcotics, and its standard database has been optimized and enriched; it can detect black powder without ignition at 300 mW laser power, while also providing the composition of the black powder; it can perform laser surface scanning, directly detecting pure potassium permanganate without ablating the equipment.

[0039] As an optional implementation, the coding and reading module uses nanotechnology to achieve invisible coding or ordinary coding, and uses algorithm-coding to identify partially damaged evidence codes.

[0040] Optionally, the coding and reading module is used to spray codes onto the evidence bags of the evidence to be inspected and scan the codes to upload them to the mobile terminal module, confirming the uniqueness, authenticity, and validity of the evidence, and realizing evidence traceability and control. The coding and reading module is not limited to using handheld coding and reading modules.

[0041] The coding and reading modules are not limited to using nanotechnology to achieve invisible or ordinary coding. Combined with dedicated identification equipment, they can quickly identify invisible codes. Simultaneously, through an algorithm-coding system, they can identify codes on partially damaged evidence, offering wide applicability and compatibility with traditional anti-counterfeiting technologies. Customized one-to-one unique identification systems and dedicated reading devices are also available, and have been tested by SGS to have no toxic side effects on humans or the environment.

[0042] Optionally, in the context of biosafety integrated detection system, taking food safety during major events as an example, the detection methods and procedures of the aforementioned system are not limited to, for example, those used in biosafety control environments. Figure 2 As shown, it includes: First, samples are collected. Then, the samples are encoded using a mobile terminal module. The codes are recorded using a coding and reading module. Next, each module is tested. Finally, the mobile terminal module submits the data and generates a risk assessment report.

[0043] Specifically, the detection methods and procedures for each module are as follows: (1) Chemical sensor module: used for real-time monitoring of toxic and harmful gases in the air. After turning on the power and preheating the equipment for 10 minutes, start the software and hardware of the gas sampling device to monitor toxic and harmful gases such as hydrogen sulfide, carbon monoxide, and methane in real time.

[0044] (2) Handheld inkjet and code reading module: Perform inkjet and code operation on the evidence bag after the sample is collected.

[0045] (3) Fully automated nucleic acid analysis module: used to detect viruses in water and food. Select a test kit for viruses that may be prevalent recently (such as influenza A, influenza B, or COVID-19 test kits), and follow the procedure of "swab sampling → swab insertion into the test kit → machine testing → results feedback to the mobile terminal". The whole process takes about 20 minutes.

[0046] (4) Colloidal gold card smart card reader module: for preliminary screening of toxins, drugs, pesticide residues, explosives, etc. The operation process is as follows: collect samples on site → sample pretreatment → drop extract onto the test card → read the card through the device or mobile APP → display the results.

[0047] (5) Portable mass spectrometry module: Further testing of samples that tested positive by the colloidal gold card smart reader module. Take approximately 1 gram of sample; solid samples should be chopped and placed in a 10 ml centrifuge tube. Add 4 ml of acetonitrile, shake well for 1 minute, and allow to stand for 3 minutes. Use a pipette to transfer 100 μL of supernatant to the back window of the PCS kit. Construct a spectrum for the newly detected toxins.

[0048] (6) Enhanced Raman module: Quickly identify the chemical composition of unknown substances, covering organic matter, inorganic matter, drugs, explosives, narcotics, etc.

[0049] (7) Mobile terminal module: Assists in the tracing and control of physical evidence, acquires test results and conducts comprehensive analysis and judgment. It adopts intelligent data analysis technology to realize multi-source data interaction and comprehensive judgment, and improves the accuracy of testing; realizes real-time storage, analysis and visualization of massive biological data; uses deep learning technology to extract features from multi-source test data, and combines geographic information system to realize dynamic monitoring and rapid response of risk areas, and completes biological sample classification and risk assessment.

[0050] Optionally, in a food safety traceability environment, taking meat and dairy products as examples, the detection methods and procedures of the aforementioned integrated biosafety detection system are not limited to, for example, as described above. Figure 3 As shown, it includes: First, samples are collected. Then, the samples are encoded using a mobile terminal module. The codes are recorded using a coding and reading module. Next, each module is tested. Finally, the mobile terminal module submits the data and generates a risk assessment report.

[0051] Specifically, the detection methods and procedures for each module are as follows: (1) Chemical sensor module: used for real-time monitoring of toxic and harmful gases in the air. After turning on the power and preheating the equipment for 10 minutes, start the software and hardware of the gas sampling device to monitor toxic and harmful gases such as volatile organic compounds, including ketones (acetone, etc.), aldehydes (formaldehyde, acetaldehyde, etc.), alcohols (methanol, ethanol, n-butanol, isopropanol, etc.), aromatics (benzene, o / p / m xylene), and acids (ethyl acetate) in real time.

[0052] (2) Handheld inkjet printing and reading module: performs inkjet printing and coding operations on the evidence bags after the samples are collected.

[0053] (3) Fully automated nucleic acid analysis module: used to detect viruses in water and food. Select test kits for viruses that may be prevalent recently (such as influenza A, influenza B, and novel coronavirus test kits), and operate according to the process of "swab sampling → swab insertion into test kit → machine testing → result feedback to mobile terminal (20 minutes)". Perform species identification on meat, select test kits for meat suspected of being adulterated, such as duck meat adulterated in mutton, and perform species identification.

[0054] (4) Colloidal gold card / fluorescent card smart card reading module: for preliminary screening of toxins, pesticide residues, etc. The operation process is: "collect samples on site → sample pretreatment → drop extract onto the test card → read the card through the device or mobile APP → display the results".

[0055] (5) Portable mass spectrometry module: For further testing of samples that test positive for colloidal gold card. Take about 1 gram of sample (solid samples need to be chopped), place it in a 10 ml centrifuge tube, add 4 ml of acetonitrile, shake well for 1 minute, let stand for 3 minutes after thorough mixing, and transfer 100 μL of supernatant to the back window of the PCS kit using a pipette.

[0056] (6) Enhanced Raman module: Quickly identify the chemical composition of unknown substances, covering organic matter, inorganic matter, drugs, explosives, narcotics, etc.

[0057] (7) Mobile terminal module: Assists in the tracing and control of physical evidence, acquires test results and conducts comprehensive analysis and judgment. It adopts intelligent data analysis technology to realize multi-source data interaction and comprehensive judgment, and improves the accuracy of testing; realizes real-time storage, analysis and visualization of massive biological data; uses deep learning technology to extract features from multi-source test data, and combines geographic information system to realize dynamic monitoring and rapid response of risk areas, and completes biological sample classification and risk assessment.

[0058] In this embodiment, a multifunctional detection platform was constructed to meet the data fusion detection needs of multiple types of samples, achieving comprehensive monitoring of toxins and viruses for the first time. A rapid biosafety detection system was also built, utilizing portable equipment to establish a suitcase-style mobile laboratory for real-time on-site rapid testing. Furthermore, a multi-layered technical system for toxin and drug detection was established: initial screening using immunoassay, followed by precise subdivision using mass spectrometry and Raman analysis; and detection of airborne toxic substances using sensor analysis technology, achieving comprehensive screening of toxins and drugs, covering multi-dimensional inspection of water, air, and physical objects. Subsequently, intelligent data analysis technology was employed to achieve interaction and comprehensive judgment of multi-source data, improving testing accuracy. A cloud computing platform was also constructed to achieve real-time storage, analysis, and visualization of massive biological data. Deep learning technology was used to extract features from multi-source detection data, combined with a geographic information system to achieve dynamic monitoring and rapid response of risk areas, enabling the classification and risk assessment of biological samples.

[0059] In this embodiment, a rapid biosafety detection system integrating multiple cutting-edge technologies was constructed. This system integrates immunoassay technology, mass spectrometry analysis technology, Raman analysis technology, sensor analysis technology, and intelligent data analysis technology to form a portable on-site rapid detection system, enabling rapid screening and accurate identification of toxins and drugs, and comprehensively improving the early warning and emergency response capabilities for biological threats and toxin threats.

[0060] Addressing the bottlenecks of traditional testing technologies, such as reliance on laboratories, long processing times, and complex procedures, the biosafety integrated testing system constructed in this application enables on-site, real-time analysis. Utilizing portable devices and an intelligent platform, it solves the problem of sample transportation delays. It establishes a rapid on-site testing technology system encompassing "sample collection - intelligent analysis - data storage," shortening the testing-decision cycle to within 30 minutes.

Claims

1. An integrated biosafety detection system, characterized in that, include: Intelligent card reader module, fully automated nucleic acid analysis module, portable mass spectrometry module, chemical sensor module, enhanced Raman module, inkjet coding and reading module, mobile terminal module; The smart card reader module is used to detect harmful substances in the test object and provide a property judgment; The fully automated nucleic acid analysis module is used for pathogen detection, pathogenic microorganism detection, and species identification in the analytes. The portable mass spectrometry module is used to perform mass spectrometry analysis and detection of compounds in the analyte, and to analyze the content and molecular structure of the analyte. The chemical sensor module is used to determine the type of gas to be tested through an algorithm; The enhanced Raman module is used to identify the chemical composition of unknown substances; The coding and reading module is used to spray code onto the evidence bag of the object to be tested and scan the code to upload it to the mobile terminal module; The mobile terminal module is used for tracing and controlling the test object, assisting in detection and obtaining test results, and comprehensive analysis and judgment.

2. The integrated biosafety detection system as described in claim 1, characterized in that, The smart card reader module is a colloidal gold card / fluorescent card smart card reader module, and supports simultaneous reading of multiple cards.

3. The integrated biosafety detection system as described in claim 2, characterized in that, The intelligent card reader module calculates the concentration of various harmful substances in the substance to be tested and provides a negative or positive result. The harmful substances include pesticide residues, veterinary drug residues, heavy metal residues, illegal additives, and fungal toxins.

4. The integrated biosafety detection system as described in claim 1, characterized in that, The fully automated nucleic acid analysis module obtains the test results of the sample by inserting the sampled swab into the test box.

5. The integrated biosafety detection system as described in claim 1, characterized in that, The portable mass spectrometry module uses in-situ direct ionization to perform mass spectrometry analysis and detection of compounds in the analyte, and uses multi-stage tandem mass spectrometry to resolve trace components in complex mixtures.

6. The integrated biosafety detection system as described in claim 1, characterized in that, The portable mass spectrometry module performs single or combined detection of target analytes and can detect multiple target analytes in complex mixtures.

7. The integrated biosafety detection system as described in claim 1, characterized in that, The chemical sensor module employs a high-dimensional sensor array and combines artificial intelligence algorithms to distinguish and identify different types of gases.

8. The integrated biosafety detection system as described in claim 7, characterized in that, The chemical sensor module's bio-high-dimensional sensor array includes 80 miniaturized MEMS sensors.

9. The integrated biosafety detection system as described in claim 1, characterized in that, The enhanced Raman module identifies the chemical composition of unknown substances by adding an enhancing reagent to the sample.

10. The integrated biosafety detection system as described in claim 1, characterized in that, The coding and reading modules use nanotechnology to achieve invisible coding or ordinary coding, and use algorithm-coding to identify the codes of some damaged evidence.

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