Luminescent synapse transistor-based sensory computing system and integrated device

Abstract

The application provides a luminescent synapse transistor-based sensing, computing, and therapy system and an integrated device, and the luminescent synapse transistor-based sensing, computing, and therapy system comprises a physiological signal acquisition module, which acquires physiological signals and outputs a computing signal to a computing light therapy module according to the physiological signals; the computing light therapy module performs in-memory computing according to the computing signal in a computing mode and outputs a computing result signal; when a light therapy mode signal is detected, the computing light therapy module is switched to a light therapy mode to output treatment light according to the light therapy mode signal; and a control module is used for comparing the computing result signal with a threshold value and outputting a light therapy mode signal to the computing light therapy module according to a comparison result. The computing light therapy module can perform in-memory computing on externally input physiological signals in the computing mode, and can also output treatment light according to a diagnosis result of the control module in the light therapy mode, for light therapy, while bearing the functions of computing and light therapy, thereby reducing system complexity and energy consumption and improving system response speed.

Description

Technical Field

[0001] This invention relates to the field of organic electronics science and technology, and in particular to a sensing and computing system and integrated device based on light-emitting synaptic transistors. Background Technology

[0002] With the rapid development of wearable electronic devices, flexible sensing technology and artificial intelligence algorithms, intelligent diagnostic and treatment devices can achieve real-time diagnosis of cardiovascular diseases such as arrhythmia identification and myocardial infarction warning by continuously monitoring and intelligently analyzing physiological signals (such as electrocardiogram signals and photoplethysmography pulse wave signals).

[0003] Existing diagnostic and treatment systems typically require transmitting acquired physiological signals to an external processor for analysis, and then controlling the treatment device to intervene when abnormal diagnostic results are detected. The identification results must be transmitted to an external treatment module and cannot directly produce a therapeutic effect. Physiological signal detection, calculation, and treatment are all performed by independent modules, resulting in complex system circuitry, frequent data transmissions, and additional time spent on data transmission. This leads to high energy consumption, long treatment response delays, and low timeliness in responding to symptoms.

[0004] Therefore, existing technologies still need improvement and development. Summary of the Invention

[0005] In view of the shortcomings of the prior art, the purpose of this invention is to provide a sensory-based therapeutic system and integrated device based on light-emitting synaptic transistors, so as to solve the problems of existing diagnostic and therapeutic systems where physiological signal detection, calculation and treatment are completed by separate modules, the system circuit structure is complex, data transmission is frequent, extra time is spent on data transmission, energy consumption is high and treatment response is long, and the response time to the disease is low.

[0006] The technical solution of the present invention is as follows: This invention provides a sensory-based therapeutic system based on light-emitting synaptic transistors, comprising: A physiological signal acquisition module is used to acquire physiological signals and output storage signals based on the physiological signals; The storage-based phototherapy module includes a light-emitting synaptic transistor array and a peripheral storage-based circuit. The peripheral storage-based circuit is connected to the physiological signal acquisition module and is used in storage-based mode to drive the light-emitting synaptic transistor array to perform in-memory calculation when the storage-based signal is acquired. The light-emitting synaptic transistor array outputs the storage-based result signal. A control module, connected to the storage-based phototherapy module, is used to acquire the storage-based result signal and, based on the comparison result of the storage-based result signal with a predetermined threshold, output a phototherapy mode signal to the storage-based phototherapy module. The stored-data phototherapy module switches to phototherapy mode when it detects a phototherapy mode signal, and the peripheral stored-data circuit outputs a laser trigger signal when it detects a phototherapy mode signal. The light-emitting synaptic transistor array includes a plurality of light-emitting synaptic transistors, each containing a light-emitting active material, for performing in-memory computation in memory mode and for activating therapeutic light when the laser trigger signal is received in phototherapy mode.

[0007] In a further embodiment of the present invention, the physiological signal acquisition module includes a signal acquisition unit and a processing and encoding unit; wherein, The signal acquisition unit is used to acquire physiological signals and output physiological electrical signals based on the physiological signals; The input end of the processing encoding unit is connected to the signal acquisition unit, and the output end is connected to the storage and computation phototherapy module; The processing and encoding unit is used to acquire the physiological electrical signal, perform signal preprocessing and signal encoding on the physiological electrical signal to generate the stored signal, and output the stored signal to the stored phototherapy module.

[0008] In a further embodiment of the present invention, the control module includes: a signal reading unit, a control unit, and a feedback drive unit; wherein, The input end of the signal reading unit is connected to the storage-based phototherapy module, and the output end is connected to the control unit. The signal reading unit is used to acquire the storage-based result signal in storage-based mode, perform signal processing to obtain the storage-based reading signal, and output the storage-based reading signal to the control unit. The output of the control unit is connected to the feedback drive unit and is used to compare the storage and reading signal with the predetermined threshold. When the storage and reading signal exceeds the predetermined threshold, the control unit outputs a phototherapy trigger signal to the feedback drive unit. The feedback drive unit is connected to the storage-based phototherapy module and outputs the phototherapy mode signal to the storage-based phototherapy module according to the phototherapy trigger signal.

[0009] In a further embodiment of the present invention, the peripheral memory circuit includes a pulse driving unit and a read driving unit. The pulse driving unit is connected to the control terminal of each of the light-emitting synaptic transistors in the light-emitting synaptic transistor array. The pulse driving unit is used to output a preset programming pulse signal to the control terminal of the corresponding light-emitting synaptic transistor in memory mode to adjust the calculation weight of the light-emitting synaptic transistor. In phototherapy mode, the pulse driving unit outputs a laser trigger signal to the control terminal of the corresponding light-emitting synaptic transistor according to the phototherapy mode signal. The read drive unit is used to receive the storage signal and is connected to the input terminal of each of the light-emitting synaptic transistors in the light-emitting synaptic transistor array. It is used to output the read data voltage to the corresponding light-emitting synaptic transistor according to the storage signal. The light-emitting synaptic transistor array writes the storage signal in storage mode and performs in-memory calculations based on the calculation weights and the read data voltage to obtain the calculation results. The output terminals of each light-emitting synaptic transistor are respectively connected to the control module, and are used to output storage result signals to the control module based on the calculation results when the read data voltage is detected. At the same time, the light-emitting synaptic transistor outputs therapeutic light when the laser trigger signal is acquired at the control terminal in phototherapy mode.

[0010] In a further embodiment of the present invention, the light-emitting synaptic transistor array is a rectangular array, a cross array, an independently addressable array, a partitioned array, or a three-dimensional integrated array.

[0011] In a further embodiment of the present invention, the computational weight in the light-emitting synaptic transistor array is represented by the conductance state of a single light-emitting synaptic transistor, or the computational weight in the light-emitting synaptic transistor array is represented by the conductance state of two light-emitting synaptic transistors.

[0012] In a further embodiment of the present invention, the stored result signal is the output current of the stored phototherapy module; the signal reading unit includes a current differential circuit and an analog-to-digital conversion circuit; The input terminal of the current differential circuit is connected to the storage-based phototherapy module, and the output terminal of the current differential circuit is connected to the analog-to-digital converter circuit. The current differential circuit is used to acquire the storage-based result signal, calculate the current differential result based on the storage-based result signal, and output the current differential result to the analog-to-digital converter circuit. The analog-to-digital conversion circuit is connected to the control unit and is used to perform analog-to-digital conversion on the current difference result to obtain a storage and read signal, and output the storage and read signal to the control unit.

[0013] In a further embodiment of the present invention, the light-emitting synaptic transistor includes, from bottom to top, a substrate, an input electrode, an output electrode, a semiconductor channel layer, a light-emitting ion gel layer, and a gate. The gate is used to receive programming pulse signals and laser trigger signals; The luminescent ion gel layer contains anions, luminescent active substances, and co-reactants. The anions move closer to or further away from the semiconductor channel layer according to the programmed pulse signal. The input electrode and the output electrode serve as the source and drain of the light-emitting synaptic transistor, respectively, and are used as input terminals to receive storage signals or as output terminals to connect to the control module. The luminescent active material undergoes a redox reaction with the co-reactant under the drive of the laser trigger signal to form excited-state ions, which emit therapeutic light when returning to the ground state.

[0014] In a further embodiment of the present invention, the luminescent ion gel layer adopts an ion gel structure comprising polyvinylidene fluoride-hexafluoropropylene copolymer, 1-n-butyl-1-methylpyrrolidine di(trifluoromethanesulfonyl)imide, terpyridine ruthenium chloride hexahydrate, and tri-n-propylamine, wherein the 1-n-butyl-1-methylpyrrolidine di(trifluoromethanesulfonyl)imide is used to provide anions, and the luminescent active material is terpyridine ruthenium chloride hexahydrate.

[0015] Based on the same inventive concept, the present invention provides an integrated device comprising a protective housing and the aforementioned light-emitting synaptic transistor-based sensory-memory-therapy system. The light-emitting synaptic transistor-based sensory-memory-therapy system is disposed inside the protective housing. The physiological signal acquisition module and the phototherapy module are in close contact with the user. The physiological signal acquisition module is used to detect the user's physiological signals. The phototherapy module is used to perform in-memory calculations in the phototherapy mode and to output therapeutic light in the phototherapy mode.

[0016] This invention provides a phototherapy system and integrated device based on light-emitting synaptic transistors (LEDs). The phototherapy system includes: a physiological signal acquisition module for acquiring physiological signals and outputting a phototherapy signal to a phototherapy module based on the physiological signals; a phototherapy module connected to the physiological signal acquisition module, which acquires the phototherapy signals in phototherapy mode, performs in-memory calculations based on the phototherapy signals, and outputs a phototherapy mode signal to the phototherapy module; and a control module connected to the phototherapy module, which acquires the phototherapy mode signal and outputs a phototherapy mode signal to the phototherapy module based on a comparison of the phototherapy mode signal with a predetermined threshold. The phototherapy module switches to phototherapy mode when it detects the phototherapy mode signal and outputs therapeutic light according to the phototherapy mode signal. In this invention, the phototherapy module can perform in-memory calculations on externally input physiological signals in phototherapy mode, and simultaneously output therapeutic light for phototherapy based on the diagnostic results of the control module in phototherapy mode, thus simultaneously undertaking phototherapy and phototherapy functions, reducing system complexity and energy consumption, and improving system response speed. Attached Figure Description

[0017] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on the structures shown in these drawings without creative effort.

[0018] Figure 1 This is a schematic diagram of a sensory computing system based on a light-emitting synaptic transistor in a preferred embodiment of the present invention.

[0019] Figure 2 This is a schematic diagram of a sensory computing system based on a light-emitting synaptic transistor in another preferred embodiment of the present invention.

[0020] Figure 3 This is a schematic diagram of the structure of the light-emitting synaptic transistor in this invention.

[0021] Figure 4 This is the transfer characteristic curve of the light-emitting synaptic transistor in this invention.

[0022] Figure 5 This is the optical response characteristic curve of the light-emitting synaptic transistor in this invention.

[0023] Figure 6 This is a diagram showing the electro-optical synchronization response characteristics of the light-emitting synaptic transistor in this invention under continuous voltage pulses of different amplitudes.

[0024] Figure 7 This is the schematic diagram of the single-device weighting circuit in this invention.

[0025] Figure 8 This is the schematic diagram of the dual-device weighted circuit in this invention.

[0026] Figure 9 This is a flowchart of the fabrication method of the light-emitting synaptic transistor array in this invention.

[0027] Figure 10 This is a comparative image of a heart slice treated by the device in this invention.

[0028] The labels in the attached diagram are as follows: 1. Gate electrode; 2. Luminescent ion gel layer; 3. Semiconductor channel layer; 41. Input electrode; 42. Output electrode; 5. Substrate; 100. Physiological signal acquisition module; 110. Signal acquisition unit; 120. Processing and encoding unit; 200. Storage and phototherapy module; 210. Peripheral storage and computing circuit; 211. Pulse driving unit; 212. Reading driving unit; 220. Luminescent synaptic transistor array; 221. Luminescent synaptic transistor; 300. Control module; 310. Signal reading unit; 311. Current differential circuit; 312. Analog-to-digital conversion circuit; 320. Control unit; 330. Feedback driving unit. Detailed Implementation

[0029] This invention provides a sensory-based therapeutic system and integrated device based on light-emitting synaptic transistors. To make the objectives, technical solutions, and effects of this invention clearer and more explicit, the invention is further described in detail below with reference to the accompanying drawings and examples. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

[0030] In the implementation methods and claims, unless otherwise specified in the text, the terms "a," "an," "the," and "the" may also include plural forms. If the embodiments of the present invention involve descriptions of "first," "second," etc., such descriptions are for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of indicated technical features. Therefore, a feature defined with "first" or "second" may explicitly or implicitly include at least one of those features.

[0031] It should be further understood that the term "comprising" as used in this specification means the presence of the stated features, integers, steps, operations, elements, and / or components, but does not exclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and / or groups thereof. It should be understood that when we say an element is "connected" or "coupled" to another element, it can be directly connected or coupled to the other element, or there may be intermediate elements. Furthermore, "connected" or "coupled" as used herein can include wireless connections or wireless coupling. The term "and / or" as used herein includes all or any unit and all combinations of one or more associated listed items.

[0032] It will be understood by those skilled in the art that, unless otherwise defined, all terms used herein (including technical and scientific terms) have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. It should also be understood that terms such as those defined in general dictionaries should be understood to have the same meaning as in the context of the prior art, and should not be interpreted in an idealized or overly formal sense unless specifically defined as herein.

[0033] Furthermore, the technical solutions of the various embodiments can be combined with each other, but this must be based on the ability of those skilled in the art to implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be considered that such combination of technical solutions does not exist and is not within the scope of protection claimed by this invention.

[0034] With the development of wearable electronics, flexible sensing, and artificial intelligence technologies, existing medical systems are now capable of continuously collecting physiological signals such as electrocardiograms and photoplethysmography (PPG) pulse waves, and identifying disease states such as abnormal heart rate and myocardial infarction. Current intelligent diagnostic and treatment systems typically include sensors, memory, processors, and treatment devices. After the sensors collect physiological signals, the data needs to be transmitted to an external processor for analysis; when an abnormal state is detected, the processor then controls an independent light source, electrical stimulator, or other treatment device for intervention.

[0035] The inventors discovered that because perception, computation, and treatment are performed by different modules, it easily leads to problems such as complex system structure, numerous data transmissions, high energy consumption, and delayed treatment response. To reduce data transmission between memory and processor, existing technologies have further proposed neuromorphic devices such as memristors and synaptic transistors. These devices can store data using their own conductance states and perform in-memory computation, making them suitable for physiological signal recognition and disease classification, and capable of operating on the processor. However, most neuromorphic devices can only perform storage and computation; the recognition results still need to be transmitted to an external treatment module and cannot be directly used to execute treatment operations. In addition, although existing light-emitting transistors or light-emitting synaptic devices exhibit electrically regulated light emission functions, their light emission is usually used for display or information representation, rarely for treatment, and they cannot simultaneously possess in-memory computation functions; furthermore, existing technologies have not yet fully realized the completion of disease recognition and treatment output by the same device or array.

[0036] To solve the technical problems existing in the current technology, such as Figure 1As shown, a physiological signal acquisition module 100 is used to acquire physiological signals and output a storage-based signal based on the physiological signals; a storage-based phototherapy module 200 includes a light-emitting synaptic transistor array 220 and a peripheral storage-based circuit 210. The peripheral storage-based circuit 210 is connected to the physiological signal acquisition module 100 and, in storage-based mode, drives the light-emitting synaptic transistor array 220 to perform in-memory calculations when the storage-based signal is acquired, and the light-emitting synaptic transistor array 220 outputs a storage-based result signal; a control module 300 is connected to the storage-based phototherapy module 200 and is used to acquire... The stored computation result signal is used to compare the stored computation result signal with a predetermined threshold, and a phototherapy mode signal is output to the stored computation phototherapy module 200. The stored computation phototherapy module 200 switches to phototherapy mode when it detects the phototherapy mode signal, and the peripheral stored computation circuit 210 outputs a laser trigger signal when it detects the phototherapy mode signal. The light-emitting synaptic transistor array 220 includes a plurality of light-emitting synaptic transistors 221, each containing a light-emitting active material, used to perform in-memory calculations in stored computation mode and to excite therapeutic light when the laser trigger signal is received in phototherapy mode.

[0037] Specifically, the physiological signal acquisition module 100 is used to contact the body parts of the test subject to detect physiological signals at the test location. These physiological signals include, but are not limited to, photoplethysmography (PPG) signals, electrocardiogram (ECG) signals, electroencephalogram (EEG) signals, electromyogram (EMG) signals, blood oxygen saturation signals, pulse signals, temperature signals, and pressure signals. These physiological signals can be used to characterize the physiological signs of the test subject. The storage-based phototherapy module 200 operates in storage-based mode by default and receives the storage-based signals in real time, performing in-memory calculations on them. When a storage-based signal is input, the storage-based phototherapy module 200 internally contains at least one light-emitting synaptic transistor, forming a neural network structure for diagnosis. The storage-based result signal output by the storage-based phototherapy module 200 directly reflects the degree of matching between the input storage-based signal and the stored weights, thereby completing the rapid classification and identification of the current physiological state. The control module 300 collects the stored calculation result signal in real time and compares it with a predetermined threshold range. If the stored calculation result signal falls within the threshold range, it proves that the current physiological state is within the preset normal fluctuation range, and the stored calculation phototherapy module 200 continues to work in stored calculation mode, with the system continuing to maintain cyclic detection. Otherwise, the control module 300 outputs a phototherapy mode signal to the stored calculation phototherapy module 200. The control module 300 can be a circuit with logic operation and intelligent control functions, composed of a microcontroller, field-programmable gate array, digital signal processor, application-specific integrated circuit, or any one or more other intelligent control structures.

[0038] After detecting a phototherapy mode signal, the in-memory phototherapy module 200 switches to phototherapy mode. This phototherapy mode signal is a driving signal that enables the in-memory phototherapy module 200 to emit light. Under this signal, the module operates in electrochemiluminescence mode and emits therapeutic light, which is bio-modulated light with a specific wavelength and intensity. This therapeutic light acts on the target resistance region of the tested object to achieve phototherapy. Therefore, in this embodiment, the in-memory phototherapy module 200 can perform in-memory calculations and emit light simultaneously for phototherapy through the same control terminal. There is no need to transmit large amounts of raw data to an external processor; all calculations are completed internally within the in-memory phototherapy module 200, reducing power consumption and transmission latency. At this time, the peripheral in-memory circuit 210 outputs a laser trigger signal to each light-emitting synaptic transistor 221. This laser trigger signal is applied to the control terminal of the device, exciting the luminescent active material in the device to undergo an electrochemical oxidation-reduction reaction, generating an excited-state luminescent material. When the excited state returns to the ground state, it releases therapeutic light, which can then be reused as a light source to directly excite therapeutic light and act on the target tissue region, achieving phototherapy intervention.

[0039] In some preferred embodiments, the physiological signal acquisition module 100 includes a signal acquisition unit 110 and a processing and encoding unit 120; wherein, the signal acquisition unit 110 is used to acquire physiological signals and output physiological electrical signals according to the physiological signals; the input terminal of the processing and encoding unit 120 is connected to the signal acquisition unit 110, and the output terminal is connected to the storage and computation phototherapy module 200; the processing and encoding unit 120 is used to acquire the physiological electrical signals, perform signal preprocessing and signal encoding on the physiological electrical signals to generate the storage and computation signal, and output the storage and computation signal to the storage and computation phototherapy module 200.

[0040] Specifically, the signal acquisition unit 110 is connected to the processing and encoding unit 120, and is used to acquire the physiological signals of the object to be monitored and transmit the acquired physiological signals to the processing and encoding unit 120. The processing and encoding unit 120 is connected to the input terminal of the storage-based phototherapy module 200, and is used to amplify, filter, normalize, segment and / or encode the physiological signals, and convert the processed signals into voltage signals or electrical pulse signals suitable for driving the storage-based phototherapy module 200.

[0041] For further details regarding the present invention, please refer to the following: Figure 2 , Figure 7 and Figure 8The peripheral in-memory computing circuit includes a pulse driving unit 211 and a read driving unit 212. The pulse driving unit 211 is connected to the control terminal of each of the light-emitting synaptic transistors 221 in the light-emitting synaptic transistor array 220. In in-memory computing mode, the pulse driving unit 211 outputs a preset programming pulse signal to the control terminal of the corresponding light-emitting synaptic transistor 221 to adjust the calculation weight of the light-emitting synaptic transistor 221. In phototherapy mode, the pulse driving unit 211 outputs a laser trigger signal to the control terminal of the corresponding light-emitting synaptic transistor 221 according to the phototherapy mode signal. The read driving unit 212 is used to receive the in-memory computing signal and connect with the light-emitting synaptic transistor. The input terminals of each of the light-emitting synaptic transistors 221 in the transistor array 220 are connected to output a read data voltage to the corresponding light-emitting synaptic transistor 221 according to the memory-based signal; the light-emitting synaptic transistor array 220 writes the memory-based signal in memory-based mode and performs in-memory calculation according to the calculation weight and the read data voltage to obtain the calculation result; the output terminals of each of the light-emitting synaptic transistors 221 are respectively connected to the control module 300, and are used to output a memory-based result signal to the control module 300 according to the calculation result when the read data voltage is detected; at the same time, the light-emitting synaptic transistor 221 outputs therapeutic light when the laser trigger signal is acquired at the control terminal in phototherapy mode.

[0042] In this embodiment, the storage-based phototherapy module 200, in storage-based mode, can be equivalent to forming a spiking neural network. The spiking neural network includes an input layer, a hidden pulse layer, and an output layer. The matrix of light-emitting synaptic transistors 221 can be equivalent to the hidden pulse layer, used to simulate matrix-vector multiplication operations. The pulse driving unit 211 and the read driving unit 212 constitute the peripheral storage-based circuit 210 of the light-emitting synaptic transistor array 220, used for selecting, writing to, and reading from the light-emitting synaptic transistors 221. The pulse driving unit 211 is connected to the control terminal of the light-emitting synaptic transistor array 220. In this preferred embodiment, the control terminal of the light-emitting synaptic transistor 221 is the gate 1 of the corresponding light-emitting synaptic transistor 221. Correspondingly, the input terminal of the light-emitting synaptic transistor 221 can be either the source or the drain, which can be set according to the type and connection relationship of the light-emitting synaptic transistor 221. During the write conductance operation, the control module 300 applies a programming pulse signal to the control terminal (gate 1) of the light-emitting synaptic transistor 221 via the pulse driving unit 211. This programming pulse signal is a programming electrical pulse with a voltage lower than the phototherapy mode signal, used to adjust the conductance state of the light-emitting synaptic transistor 221. Correspondingly, the pulse driving unit 211 then simultaneously works with the read driving unit 212 to select the location (column) of the storage unit and the data to be transmitted, thus implementing the write operation. It should be noted that the conductance adjustment process of the pulse driving unit 211 is performed before or simultaneously with the read / write operation; there is no specific limitation. The read drive unit 212 applies a read data voltage representing the corresponding component of the input vector between the source and drain of any of the light-emitting synaptic transistors 221. The control module 300 collects the channel current flowing through the corresponding light-emitting synaptic transistor 221. The channel current output of the light-emitting synaptic transistors 221 in the corresponding row or column is the storage result signal. The channel current output by the light-emitting synaptic transistor 221 can be used to characterize the current conductance state of the light-emitting synaptic transistor 221 at the corresponding position and the stored data. Thus, information storage, weighted representation, and conductance-weighted in-memory calculation can be achieved through the conductance state of each light-emitting synaptic transistor 221.

[0043] It should be noted that, in specific implementations, the size, connection method, and calculation method of the light-emitting synaptic transistors 221 can be changed. The array may include n rows and m columns of light-emitting synaptic transistors 221, where n and m are both positive integers. The number of rows and columns can be set arbitrarily according to the physiological signal type and treatment area. It can also adopt any existing array structure such as a cross array, an independently addressed array, a partitioned array, or a three-dimensional integrated array. Optionally, it can use an 8×8 array or an array with other row and column numbers. The light-emitting synaptic transistors 221 in the array can be driven using row-by-row addressing, column-by-column addressing, independent addressing, partitioned addressing, or global addressing. Furthermore, the computation process is not limited to a specific neural network and can employ matrix-vector multiplication, feature extraction, threshold judgment, pattern matching, or other existing calculation methods that can be implemented based on the conductance state of the light-emitting synaptic transistors 221. Meanwhile, in the storage-based phototherapy module 200, the storage-based mode and the light-emitting mode can adopt a time-sharing working method of calculating first and then emitting light, or different areas in the light-emitting synaptic transistor array 220 can respectively undertake the calculation and light-emitting functions at the same time, or some of the light-emitting synaptic transistors 221 in the light-emitting synaptic transistor array 220 can be switched from the storage-based state to the light-emitting state. These settings can be configured according to actual working needs, which will not be elaborated here.

[0044] In some preferred embodiments, the computational weights in the light-emitting synaptic transistor array 220 are represented by the conductance states of a single light-emitting synaptic transistor 221, or the computational weights in the light-emitting synaptic transistor array 220 are represented by the conductance states of two light-emitting synaptic transistors 221. Specifically, as Figure 7 As shown, when using the conductance state representation of a single light-emitting synaptic transistor 221, the input terminals of the plurality of light-emitting synaptic transistors 221 in the same row are respectively connected to the read drive unit 212, and the output terminals of the plurality of light-emitting synaptic transistors 221 in the same row are connected to each other and connected to the control module 300. The outputs of each light-emitting synaptic transistor 221 are combined into one output current, thereby providing output currents I1 to In for each row. The output current is determined by the voltage corresponding to the input data in the corresponding row and the conductance of the light-emitting synaptic transistor 221 at the corresponding position. Specifically, let the conductance of the light-emitting synaptic transistor 221 in the i-th row and j-th column be G. ij Where i = 1, 2, 3, ..., n; j = 1, 2, 3, ..., m. Conductance G ij The switching transistors (WL1, WL2, WL3, ..., WL) on the corresponding columns of the pulse drive unit 211 m The output programming pulse signal is determined. The corresponding weight w is the weight of the corresponding position light-emitting synaptic transistor 221. ij According to the preset mapping relationship, G can be used ijConfirmed. During calculation, the read drive unit 212 uses the corresponding row position switching transistors (BL1, BL2, BL3, ..., BL...). n The voltage V corresponding to the input data i When applied to the input terminal of the corresponding light-emitting synaptic transistor 221, under approximately linear readout conditions, the output current I of the corresponding light-emitting synaptic transistor 221... ij It can be represented as I ij =V i G ij After the currents of multiple light-emitting synaptic transistors at the same output terminal are combined, the j-th output current can be expressed as I. j =Σ i V i G ij This allows for the generation of output current, thereby enabling multiplication-addition or matrix-vector multiplication operations based on the conductance state of the light-emitting synaptic transistor.

[0045] In another preferred embodiment, such as Figure 8 As shown, when the conductance states of two light-emitting synaptic transistors 221 are used, the weights can be calculated using the differential conductance representation of the two light-emitting synaptic transistors 221. That is, the positive and negative weights are represented by the conductance states of a pair of light-emitting synaptic transistors 221 respectively, and the corresponding calculation results are obtained through a differential readout circuit. Specifically, in this embodiment, the outputs of the plurality of light-emitting synaptic transistors 221 in the same row are connected to each other, and each row is connected in pairs. The readout driving unit 212 uses the switching transistors (BL1+, BL1-, BL2+, BL2-, ..., BL1-) at the corresponding row positions. n +, BL n -) Apply the voltage Vn corresponding to the input data to the input terminal of the corresponding light-emitting synaptic transistor. In the two rows connected to each other, the conductivities of the light-emitting synaptic transistors 221 are respectively G + ij and G - ij Effective weight w ij It is proportional to the difference in conductivity between the two, that is: w ij =α(G + ij -G - ij ), where α is the mapping coefficient between conductance and calculation weights. For the same input voltage V i When applied to the two light-emitting synaptic transistors 221 respectively, their differential output current can be expressed as ΔI. ij =V i (G + ij -G - ijAfter the outputs of multiple differential weighting units are further aggregated, the m-th output can be expressed as: I j =Σ i V i (G + ij -G - ij During operation, the computational weights obtained from training are mapped to the light-emitting synaptic transistor array 220 using differential encoding. Positive and negative weights are represented by the difference in conductance between pairs of light-emitting synaptic transistors 221. The encoded photoplethysmography (PPG) signal is sequentially input into the array, and analog matrix-vector multiplication is performed within the array using the conductance of the PPG transistors 221 and the input voltage. The array output current, as the stored computation result signal, is processed by a current differential circuit and an analog-to-digital converter circuit, and the control unit determines the cardiovascular state.

[0046] The device structure of the light-emitting synaptic transistor is as follows: Figure 3 As shown, in some preferred embodiments, the light-emitting synaptic transistor 221 includes, from bottom to top, a substrate 5, an input electrode 41, an output electrode 42, a semiconductor channel layer 3, a light-emitting ion gel layer 2, and a gate 1; the gate 1 is used to receive programming pulse signals and laser trigger signals; the light-emitting ion gel layer 2 contains anions, light-emitting active materials, and co-reactants, and the anions move closer to or further away from the semiconductor channel layer 3 according to the programming pulse signals; the input electrode 41 and the output electrode 42 serve as the source and drain of the light-emitting synaptic transistor 221, respectively, and are used as input terminals to receive storage signals, or as output terminals to connect to the control module 300; the light-emitting active materials undergo a redox reaction with the co-reactants under the drive of the laser trigger signal to form excited-state ions, and the excited-state ions emit therapeutic light when returning to the ground state.

[0047] In some preferred embodiments, the substrate 5 provides transparent support and structural stability for the light-emitting synaptic transistor 221. The substrate 5 can be made of rigid or flexible materials, specifically, it can be one of conductive glass, silicon wafer, polyethylene terephthalate (PET), polyimide, and polydimethylsiloxane. The gate 1 is a metal electrode. The light-emitting ion gel layer 2 is an ion-conductive adhesive, comprising a polymer matrix, ion-conductive components, light-emitting active materials, and co-reactants. The semiconductor channel layer 3 is a semiconductor material capable of generating tunable conductivity under ion action, including but not limited to poly(3-hexylthiophene) (P3HT), other organic semiconductors, metal oxide semiconductors, two-dimensional semiconductors, perovskite semiconductors, or composite materials thereof. Optionally, it can be a P3HT channel layer. The input electrode 41 and the output electrode 42 are each composed of two ITO electrodes disposed on the substrate 5, and one of the two electrodes can be used as the source, while the other serves as the drain. The input electrode 41 and the output electrode 42 are each made of a conductive material, which may include, but is not limited to, indium tin oxide, gold, silver, aluminum, copper, platinum, graphene, or conductive polymers. The two ITO electrodes are located on opposite sides of the semiconductor channel layer 3, with one ITO electrode serving as the source and the other as the drain. Since the two ITO electrodes are interchangeable in the light-emitting synaptic transistor structure, their specific left-right orientation is not limited. The semiconductor channel layer 3 is disposed between the source and drain, and covers at least a portion of the source and drain surfaces. The light-emitting ion gel layer 2 is disposed between the semiconductor channel layer 3 and the gate 1, with the gate 1 disposed on the side of the light-emitting ion gel layer 2 away from the semiconductor channel layer 3.

[0048] The polymer matrix in the luminescent ionogel layer 2 includes, but is not limited to, polyvinylidene fluoride-hexafluoropropylene copolymer, polyethylene oxide, polymethyl methacrylate, or other gel polymers. The ion-conducting component can be implemented using, but is not limited to, ionic liquids, polymer electrolytes, or solid electrolytes. The luminescent active material can be implemented using, but is not limited to, ruthenium complexes, iridium complexes, organic light-emitting molecules, quantum dots, or perovskite light-emitting materials. The co-reactants include reducing agents or oxidizing agents capable of undergoing electrochemiluminescence reactions with the luminescent active material.

[0049] In in-memory mode, a gate voltage or electrical pulse below the light-emitting operating threshold of the light-emitting synaptic transistor 221 is applied to the gate electrode to avoid triggering the light-emitting process and to regulate the conductivity state of the semiconductor channel. The electrical pulses include positive and / or negative polarity pulses, and their amplitude, width, number, and time interval between adjacent pulses are all adjustable. Electrical pulses of different polarities, amplitudes, widths, or numbers drive ions in the ion functional layer to migrate to, redistribute near, or migrate out of the semiconductor channel layer 3. When anions migrate to the semiconductor channel layer 3, the carrier concentration and polaron number in the channel increase, causing the channel conductivity to rise; when anions migrate out of the semiconductor channel layer 3, the channel conductivity decreases. This changes the carrier concentration and polaron number in the channel, and causes the light-emitting synaptic transistor 221 to form multiple continuously adjustable conductivity states with holding characteristics. Each conductivity state corresponds to a calculated weight value and is stably stored inside the light-emitting synaptic transistor 221 for a long period. The amplitude, width, number, and / or time interval of the applied electrical pulses can be adjusted to regulate the magnitude and duration of changes in the conductance state. These different conductance states can be used for information storage, weight representation, and in-memory computation. After weight configuration, the light-emitting synaptic transistor 221 performs in-memory computation in storage mode. At this time, the source or drain is used as an input terminal to receive a storage signal representing physiological characteristics. This storage signal is a voltage pulse sequence, and the voltage of this signal and the channel conductance jointly determine the magnitude of the current flowing through the channel according to Ohm's law. Based on Kirchhoff's laws, the storage signals of multiple light-emitting synaptic transistors 221 in the array are weighted and summed with the conductance weights stored in each light-emitting synaptic transistor 221, realizing a simulated matrix-vector multiplication operation. After in-memory computation is completed, the control module 300 determines whether the current physiological state is abnormal based on the array output current value output by the storage phototherapy module 200. The accumulated output current is the storage result signal. For example, the control module 300 may pre-store one or more threshold vectors obtained through training and calibration. In this embodiment, the physiological signal is taken as the heart rate signal. Depending on the heart state, the heart rate signal represents four states: normal heart rate, bradycardia, tachycardia, and myocardial infarction. A threshold vector is set to correspond to the decision boundaries of these four states. The control module 300 compares the converted digital value of the stored result signal with the threshold vector one by one. If the current value falls within the threshold range corresponding to the normal state, the physiological signal is determined to be normal, and the system continues monitoring. If the current value reaches or exceeds the threshold boundary corresponding to a certain abnormal state, it is determined to be the corresponding abnormal state, and the phototherapy mode is executed.

[0050] In phototherapy mode, the control module 300 applies a strong driving voltage or pulse through the gate 1 as a laser trigger signal, causing the luminescent active material and co-reactants in the ion functional layer to undergo an electrochemical reaction and generate excited-state luminescent material. During the return of the excited-state luminescent material to the ground state, it releases therapeutic light with a preset wavelength and intensity, directly irradiating the target tissue area to achieve phototherapy intervention. This causes the luminescent synaptic transistor 221 to produce light output with bio-regulating effects. In-memory computing and phototherapy operations can be achieved without the need for external independent storage chips, computing chips, or therapeutic light sources, making it suitable for intelligent medical scenarios in flexible wearable devices.

[0051] Please refer to the following: Figure 3 and Figure 9 In some embodiments, the fabrication process of the light-emitting synaptic transistor includes: M100: A patterned input electrode 41 and an output electrode 42 are fabricated on a substrate 5, wherein the input electrode 41 and the output electrode 42 are used as the source and drain, respectively. M200, a semiconductor channel layer 3 is formed on the upper surface of the input electrode 41 and the output electrode 42 and in the gap between the input electrode 41 and the output electrode 42; M300, Prepare a luminescent ion gel layer 2 containing ion-conducting components, luminescent active components and co-reactants; M400: A light-emitting ion gel layer 2 is disposed on the upper surface of a semiconductor channel layer 3, and a gate 1 is disposed on the surface of the light-emitting ion gel layer 2 to obtain a light-emitting synaptic transistor. M500: Multiple light-emitting synaptic transistors are arranged in predetermined rows and columns, and the source-drain electrode array and gate 1 array are connected to the peripheral control circuit to obtain a light-emitting synaptic transistor array 220.

[0052] In one optional method for fabricating a light-emitting synaptic transistor, a glass substrate 5 is sequentially cleaned with deionized water and isopropanol, and then dried with nitrogen. An ITO electrode with a thickness of 50 nm is fabricated on the glass substrate 5 by magnetron sputtering to obtain an input electrode 41 and an output electrode 42, which serve as one of the source and drain electrodes, respectively. The channel length is 1000 μm and the channel width is 70 μm. P3HT (poly(3-hexylthiophene-2,5-diyl)) is dissolved in chlorobenzene to prepare a solution with a concentration of 10 mg / mL. -1A P3HT solution was prepared and stirred at 100°C for 30 minutes. After oxygen plasma treatment on the surfaces of input electrode 41 and output electrode 42, the P3HT solution was spin-coated at 1500 rpm for 60 seconds and annealed at 150°C for 10 minutes to prepare semiconductor channel layer 3. P(VDF-HFP) (Poly(vinylidenefluoride-co-hexafluoropropylene)) was added to acetone and stirred at 65°C for 2 hours; then, [PYR] was added at a mass of 4 times that of P(VDF-HFP). 14 [TFSI] (N-Butyl-N-methylpyrrolidinium bis(trifluoromethanesulfonyl)imide, polyvinylidene fluoride-hexafluoropropylene copolymer) was added and stirring continued; then Ru(bpy)3Cl2 (Tris(2,2′-bipyridine)ruthenium(II) chloride, 0.15 times the mass of P(VDF-HFP) was added, and the mixture was stirred at 60°C for 2 hours; finally, tri-n-propylamine (TPrA), twice the mass of P(VDF-HFP) was added, and the mixture was stirred at 60°C for 3 hours to prepare the ion gel precursor solution. The ion gel precursor solution was then centrifuged to remove air bubbles, poured into a mold, and dried under ambient conditions to form a self-supporting luminescent ion gel film. This ion gel film was laminated onto the surface of the P3HT channel layer, and a gold gate 1 was placed on it to complete the fabrication of the luminescent synaptic transistor.

[0053] Based on this, the light-emitting synaptic transistor array 220 can be fabricated using flexible materials. For flexible light-emitting synaptic transistor arrays, patterned ITO source / drain electrode arrays and gate arrays are fabricated in batches on the substrate 5 made of flexible material. A P3HT semiconductor channel layer 3 is formed on the surface of the source / drain electrode array, and then a self-supporting ion gel film is transferred to the surface of the transistor array. Finally, the gate array is aligned and laminated with the ion gel film to achieve the batch fabrication of flexible light-emitting synaptic transistors 221, thus obtaining the flexible light-emitting synaptic transistor array 220.

[0054] The electrical performance transfer curve of the 221 light-emitting synaptic transistor is shown in the figure. Figure 4 As shown in the figure. The light intensity of the light-emitting synaptic transistor 221 varies with the gate voltage as shown in the figure. Figure 5As shown in the figure. Test results show that under low driving conditions, the light-emitting synaptic transistor 221 quenches its emission and exhibits continuously adjustable conductance and synaptic memory characteristics. Under higher driving conditions, it can generate red light with a center wavelength of approximately 620 nm. The emission initiation voltage is approximately -1.88 volts, and higher brightness is achieved at -5.5 volts, indicating that the light-emitting synaptic transistor 221 can switch between memory mode and emission mode by changing the driving conditions. The response curves of drain current and luminous intensity of the light-emitting synaptic transistor 221 under multi-voltage pulse conditions are shown in the figure. Figure 6 As shown, the yellow curve represents the applied voltage pulse, from which... Figure 6 It can be seen that as the voltage pulse amplitude changes more, the source-drain current and light intensity of the light-emitting synaptic transistor 221 increase synchronously. It is evident that the electrical and optical characteristics of the light-emitting synaptic transistor 221 respond synchronously.

[0055] Furthermore, in the luminescent ion gel layer 2, polyvinylidene fluoride-hexafluoropropylene copolymer (P(VDF-HFP)) and N-butyl-N-methylpyrrolidone-onium bis(trifluoromethanesulfonyl)imide ([PYR)) are employed. 14 The luminescent ionogel layer 2 comprises ruthenium terpyridine chloride hexahydrate (Ru(bpy)3Cl2) and tri-n-propylamine, wherein N-butyl-N-methylpyrrolidone bis(trifluoromethanesulfonyl)imide is used to provide anions, and the luminescent active material is ruthenium terpyridine chloride hexahydrate. Optionally, the luminescent ionogel layer 2 contains anions (e.g., TFSI-) that can migrate under the action of a gate electric field.

[0056] In memory mode, the anions can migrate into, enter, or approach the P3HT channel layer, or migrate out of or away from the P3HT channel layer under the influence of a reverse electric field, thereby adjusting the hole concentration and polaron number in the P3HT channel, enabling the light-emitting synaptic transistor to form multiple tunable and memory-retaining conductivity states. Specifically, when a negative pulse is applied to gate 1, TFSI- ions migrate into the P3HT channel and promote hole accumulation, increasing the channel conductivity. After the pulse is removed, some ions remain near the channel or interface, causing the channel conductivity to decay slowly and maintain a certain memory state. When a pulse of opposite polarity is applied, TFSI- ions migrate out of the channel, decreasing the channel conductivity. By changing the pulse amplitude, pulse width, and pulse number, conductivity enhancement, conductivity suppression, and multi-level conductivity modulation can be achieved.

[0057] When the applied driving intensity reaches the luminescent operating condition, Ru(bpy)3 2+ It undergoes an electrochemical redox reaction with tri-n-propylamine to form an excited state Ru(bpy)3. 2+ Excited state Ru(bpy)3 2+ Upon returning to its ground state, the light emits red light with a center wavelength of approximately 620 nm, which is the therapeutic light. This transforms the same light-emitting synaptic transistor 221 from a storage unit into a light output unit, outputting the therapeutic light. In this light output unit, the phototherapy mode signal can be used as a driving voltage to drive the light-emitting synaptic transistor 221 to emit light. As the driving voltage increases, the intensity of the therapeutic light gradually increases. Furthermore, by adjusting the pulse width, pulse number, and pulse interval, the luminous intensity, duration, and cumulative luminous effect can be further controlled. Based on this characteristic, this invention uses the light-emitting synaptic transistor 221 simultaneously as both a storage unit and a phototherapy execution unit. During the storage phase, different conductance states of the light-emitting synaptic transistor 221 are used to represent computational weights; during the phototherapy phase, the same light-emitting synaptic transistor 221 generates therapeutic light output. This avoids the need for a separate external light source and establishes a direct link between the computational results and the phototherapy output.

[0058] It should be noted that the specific structure and materials of the light-emitting synaptic transistor 221 can be replaced. The semiconductor channel is not limited to P3HT, and other organic semiconductors, metal oxides, two-dimensional semiconductors, or composite semiconductor materials can also be used; the light-emitting ion gel layer 2 can be an ion gel, solid electrolyte, polymer electrolyte, or other ion medium capable of regulating channel conductivity; the light-emitting material and its reactive components can also be replaced with other electroluminescent or electrochemiluminescent systems. The light-emitting synaptic transistor 221 can adopt a top gate, bottom gate, top contact, bottom contact, vertical or planar structure, and the materials used for the electrodes (gate 1, source, drain) and substrate 5 can also be adjusted according to the requirements of flexible, wearable, or adhesive use. The wavelength of the therapeutic light is not limited to red light of approximately 620 nm, and other visible or near-infrared light with biological effects can also be selected according to the treatment target. Existing implementations use a P3HT channel and Ru(bpy)3-containing... 2+ / TPrA ion gels can achieve synaptic conductivity modulation and electrochemiluminescence through different bias voltages, but can be replaced with other materials and structures and should not be considered the only limiting factor.

[0059] Furthermore, such as Figure 2As shown, the control module 300 includes: a signal reading unit 310, a control unit 320, and a feedback drive unit 330; wherein, the input terminal of the signal reading unit 310 is connected to the storage-based phototherapy module 200, and the output terminal is connected to the control unit 320; the signal reading unit 310 is used to acquire the storage-based result signal in storage-based mode, perform signal processing to obtain a storage-based reading signal, and output the storage-based reading signal to the control unit 320; the output terminal of the control unit 320 is connected to the feedback drive unit 330, and is used to compare the storage-based reading signal with a predetermined threshold; when the storage-based reading signal exceeds the predetermined threshold, the control unit 320 outputs a phototherapy trigger signal to the feedback drive unit 330; the feedback drive unit 330 is connected to the storage-based phototherapy module 200, and outputs the phototherapy mode signal to the storage-based phototherapy module 200 according to the phototherapy trigger signal.

[0060] The input terminal of the signal reading unit 310 is connected to the output terminal of the storage-based phototherapy module 200. The signal reading unit 310 is used to acquire the storage-based result signal, which is the output current or voltage signal generated by the light-emitting synaptic transistor array 220 in storage-based mode. Subsequently, the signal reading unit 310 performs current-to-voltage conversion, amplification, and / or analog-to-digital conversion on the storage-based result signal to obtain a storage-based reading signal. The output terminal of the signal reading unit 310 is connected to the control unit 320 to convert the read storage-based result signal into a storage-based reading signal and transmit it to the control unit 320. The control unit 320 is further connected to the light-emitting synaptic transistor array 220 and the feedback drive unit 330, and is used to perform state determination based on the storage-based reading signal obtained from the storage-based result signal in the light-emitting synaptic transistor array 220, and control the working mode of the light-emitting synaptic transistor array 220 according to the determination result. When the determination result does not meet the preset phototherapy triggering condition, the control unit 320 controls the storage-based phototherapy module 200 to continue working in storage-based mode. When the determination result meets the preset phototherapy triggering conditions, the control unit 320 outputs a phototherapy triggering signal to the feedback driving unit 330. The feedback driving unit 330 is connected to the gate 1 driving terminal of the light-emitting synaptic transistor array 220 in the storage phototherapy module 200. It is used to generate a gate 1 driving voltage or electrical pulse that reaches or exceeds the operation switching condition according to the phototherapy triggering signal, and apply it to the light-emitting synaptic transistor array 220, so that the light-emitting synaptic transistor array 220 switches from storage mode to electrochemiluminescence working mode and generates light output, forming a closed-loop working process from physiological signal acquisition, signal processing, storage recognition, state determination to light output feedback.

[0061] In a further embodiment of a preferred embodiment, the calculation weight is represented by the differential conductance of a pair of light-emitting synaptic transistors. The stored-value result signal is the output current of the stored-value phototherapy module 200; the signal reading unit 310 includes a current differential circuit 311 and an analog-to-digital converter circuit 312; the input terminal of the current differential circuit 311 is connected to the stored-value phototherapy module 200, and the output terminal of the current differential circuit 311 is connected to the analog-to-digital converter circuit 312, for acquiring the stored-value result signal and calculating the current differential result based on the stored-value result signal, and outputting the current differential result to the analog-to-digital converter circuit 312; the analog-to-digital converter circuit 312 is connected to the control unit 320, for performing analog-to-digital conversion on the current differential result to obtain the stored-value result signal, and outputting the stored-value result signal to the control unit 320.

[0062] Specifically, after the stored-in phototherapy module 200 completes the in-memory calculation in stored-in mode, the accumulated current of each row's output position is used as the stored-in result signal. Its value reflects the weighted summation result between the input physiological signal and the pre-determined weights of each light-emitting synaptic transistor in the light-emitting synaptic transistor array 220. Based on this, this preferred embodiment reduces errors caused by manufacturing differences and environmental noise in the light-emitting synaptic transistor array 220 by employing differential encoding with positive and negative weights. Specifically, each output current in the stored-in phototherapy module 200 is input to the current differential circuit 311. When the current outputs of the light-emitting synaptic transistors with positive and negative weights are combined, a subtraction operation is performed, and the resulting net current value is the output current differential result. The amplitude of this differential result characterizes the matching strength between the current input signal and the pre-stored disease feature template, thereby effectively eliminating common-mode noise and other interferences through differential processing, and improving the signal-to-noise ratio of the current differential result. The current differential circuit 311 outputs the current differential result to the analog-to-digital conversion circuit 312. The analog-to-digital conversion circuit quantizes and samples the current differential result in the analog domain at a preset sampling frequency and resolution, converts it into a digital domain storage result signal, and outputs the storage result signal to the control module 300. The control module 300 detects whether the input physiological signal is normal or not based on the storage result signal, and controls the working state of the storage phototherapy module 200 based on the detection result.

[0063] This invention discloses a sensory-based phototherapy system using light-emitting synaptic transistors (LEDs). The system acquires external physiological signals through a physiological signal acquisition module 100 and performs in-memory calculations on these signals through a phototherapy module 200. A control module 300 obtains a recognition result based on the in-memory calculation result signal. When the recognition result is normal, the system continues to acquire physiological signals; when the recognition result is abnormal, the controller applies a feedback pulse exceeding the operation switching condition to the same LED array 220, causing the array to switch from in-memory operation mode to light-emitting operation mode and output therapeutic light.

[0064] The efficacy of the sensory-based therapeutic system based on light-emitting synaptic transistors provided in this invention was verified. Taking heart rate signals as an example, myocardial fibrosis is mainly due to collagen synthesis exceeding degradation, leading to collagen accumulation. The metabolites generated during the dynamic transformation of collagen synthesis and degradation can indirectly reflect the degree of myocardial fibrosis. This scheme used male rats to establish a myocardial infarction model, with rats weighing 250±20 grams. Myocardial ischemia models were established in both the experimental and control groups by ligating the left anterior descending artery. Furthermore, one minute before reperfusion, the experimental group rats were irradiated with therapeutic light using a flexible light-emitting synaptic transistor array, maintaining light output during the early reperfusion phase. After treatment, recovery lasted 36 to 48 hours, and blood and myocardial tissue were collected for testing. Figure 10 As shown, the blue portion represents collagen deposited after myocardial ischemia. The results indicate that, compared to the control group of myocardial infarction patients who did not receive therapeutic light irradiation, the experimental group, after receiving therapeutic light output using a light-emitting synaptic transistor array, experienced reduced collagen deposition in myocardial tissue and improved some cardiac function parameters.

[0065] Based on the same inventive concept, this invention provides an integrated device comprising a protective housing and the aforementioned light-emitting synaptic transistor-based sensory-memory-therapy system. The light-emitting synaptic transistor-based sensory-memory-therapy system is disposed inside the protective housing. The physiological signal acquisition module and the phototherapy module are in close contact with the user. The physiological signal acquisition module detects the user's physiological signals, and the phototherapy module performs in-memory calculations in memory mode and outputs therapeutic light in phototherapy mode. The specific details are as described in the embodiments of the light-emitting synaptic transistor-based sensory-memory-therapy system above, and will not be repeated here.

[0066] This invention provides a sensory-based therapeutic system and integrated device based on light-emitting synaptic transistors, the advantages of which are: In storage-based phototherapy module, the storage-based calculation module can perform internal calculations on externally input physiological signals. At the same time, in phototherapy mode, it can also output therapeutic light for phototherapy based on the diagnostic results of the control module. Thus, it can simultaneously perform storage-based calculation and phototherapy functions, reduce system complexity and energy consumption, and improve system response speed.

[0067] The light-emitting synaptic transistors utilize adjustable conductance states to store information and perform in-memory calculations under the first driving condition, and generate therapeutic light output under the second driving condition. After multiple light-emitting synaptic transistors form an array, they can identify the state of physiological signals and control the same array to generate light output based on the identification results, thereby forming a closed loop of physiological signal monitoring, storage and processing, and phototherapy feedback.

[0068] It should be understood that the application of the present invention is not limited to the examples above. Those skilled in the art can make improvements or modifications based on the above description, and all such improvements and modifications should fall within the protection scope of the appended claims.

Claims

1. A sensory computing system based on light-emitting synaptic transistors, characterized in that, include: A physiological signal acquisition module is used to acquire physiological signals and output storage signals based on the physiological signals; The storage-based phototherapy module includes a light-emitting synaptic transistor array and a peripheral storage-based circuit. The peripheral storage-based circuit is connected to the physiological signal acquisition module and is used in storage-based mode to drive the light-emitting synaptic transistor array to perform in-memory calculation when the storage-based signal is acquired. The light-emitting synaptic transistor array outputs the storage-based result signal. A control module, connected to the storage-based phototherapy module, is used to acquire the storage-based result signal and, based on the comparison result of the storage-based result signal with a predetermined threshold, output a phototherapy mode signal to the storage-based phototherapy module. The stored-data phototherapy module switches to phototherapy mode when it detects a phototherapy mode signal, and the peripheral stored-data circuit outputs a laser trigger signal when it detects a phototherapy mode signal. The light-emitting synaptic transistor array includes a plurality of light-emitting synaptic transistors, each containing a light-emitting active material, for performing in-memory computation in memory mode and for activating therapeutic light when the laser trigger signal is received in phototherapy mode.

2. The sensory computing system based on light-emitting synaptic transistors according to claim 1, characterized in that, The physiological signal acquisition module includes a signal acquisition unit and a processing and encoding unit; wherein... The signal acquisition unit is used to acquire physiological signals and output physiological electrical signals based on the physiological signals; The input end of the processing encoding unit is connected to the signal acquisition unit, and the output end is connected to the storage and computation phototherapy module; The processing and encoding unit is used to acquire the physiological electrical signal, perform signal preprocessing and signal encoding on the physiological electrical signal to generate the stored signal, and output the stored signal to the stored phototherapy module.

3. The sensory computing system based on light-emitting synaptic transistors according to claim 1, characterized in that, The control module includes: a signal reading unit, a control unit, and a feedback drive unit; wherein... The input end of the signal reading unit is connected to the storage-based phototherapy module, and the output end is connected to the control unit. The signal reading unit is used to acquire the storage-based result signal in storage-based mode, perform signal processing to obtain the storage-based reading signal, and output the storage-based reading signal to the control unit. The output of the control unit is connected to the feedback drive unit and is used to compare the storage and reading signal with the predetermined threshold. When the storage and reading signal exceeds the predetermined threshold, the control unit outputs a phototherapy trigger signal to the feedback drive unit. The feedback drive unit is connected to the storage-based phototherapy module and outputs the phototherapy mode signal to the storage-based phototherapy module according to the phototherapy trigger signal.

4. The sensory computing system based on light-emitting synaptic transistors according to claim 1, characterized in that, The peripheral memory computing circuit includes a pulse driving unit and a read driving unit. The pulse driving unit is connected to the control terminal of each of the light-emitting synaptic transistors in the light-emitting synaptic transistor array. The pulse driving unit is used to output a preset programming pulse signal to the control terminal of the corresponding light-emitting synaptic transistor in memory computing mode to adjust the calculation weight of the light-emitting synaptic transistor. In phototherapy mode, the pulse driving unit outputs a laser trigger signal to the control terminal of the corresponding light-emitting synaptic transistor according to the phototherapy mode signal. The read drive unit is used to receive the storage signal and is connected to the input terminal of each of the light-emitting synaptic transistors in the light-emitting synaptic transistor array. It is used to output the read data voltage to the corresponding light-emitting synaptic transistor according to the storage signal. The light-emitting synaptic transistor array writes the storage signal in storage mode and performs in-memory calculations based on the calculation weights and the read data voltage to obtain the calculation results. The output terminals of each light-emitting synaptic transistor are respectively connected to the control module, and are used to output storage result signals to the control module based on the calculation results when the read data voltage is detected. At the same time, the light-emitting synaptic transistor outputs therapeutic light when the laser trigger signal is acquired at the control terminal in phototherapy mode.

5. The sensory computing system based on light-emitting synaptic transistors according to claim 4, characterized in that, The light-emitting synaptic transistor array can be a rectangular array, a cross array, an independently addressable array, a partitioned array, or a three-dimensional integrated array.

6. The sensory computing system based on light-emitting synaptic transistors according to claim 4, characterized in that, The computational weights in the light-emitting synaptic transistor array are represented by the conductance states of a single light-emitting synaptic transistor, or the computational weights in the light-emitting synaptic transistor array are represented by the conductance states of two light-emitting synaptic transistors.

7. The sensory-based therapeutic system based on light-emitting synaptic transistors according to claim 3, characterized in that, The stored calculation result signal is the output current of the stored phototherapy module; the signal reading unit includes a current differential circuit and an analog-to-digital conversion circuit; The input terminal of the current differential circuit is connected to the storage-based phototherapy module, and the output terminal of the current differential circuit is connected to the analog-to-digital converter circuit. The current differential circuit is used to acquire the storage-based result signal, calculate the current differential result based on the storage-based result signal, and output the current differential result to the analog-to-digital converter circuit. The analog-to-digital conversion circuit is connected to the control unit and is used to perform analog-to-digital conversion on the current difference result to obtain a storage and read signal, and output the storage and read signal to the control unit.

8. The sensory computing system based on light-emitting synaptic transistors according to claim 4, characterized in that, The light-emitting synaptic transistor includes, from bottom to top, a substrate, an input electrode, an output electrode, a semiconductor channel layer, a light-emitting ion gel layer, and a gate. The gate is used to receive programming pulse signals and laser trigger signals; The luminescent ion gel layer contains anions, luminescent active substances, and co-reactants. The anions move closer to or further away from the semiconductor channel layer according to the programmed pulse signal. The input electrode and the output electrode serve as the source and drain of the light-emitting synaptic transistor, respectively, and are used as input terminals to receive storage signals or as output terminals to connect to the control module. The luminescent active material undergoes a redox reaction with the co-reactant under the drive of the laser trigger signal to form excited-state ions, which emit therapeutic light when returning to the ground state.

9. The sensory computing system based on light-emitting synaptic transistors according to claim 8, characterized in that, The luminescent ion gel layer adopts an ion gel structure comprising polyvinylidene fluoride-hexafluoropropylene copolymer, 1-n-butyl-1-methylpyrrolidine di(trifluoromethanesulfonyl)imide, terpyridine ruthenium chloride hexahydrate, and tri-n-propylamine. The 1-n-butyl-1-methylpyrrolidine di(trifluoromethanesulfonyl)imide is used to provide anions, and the luminescent active material is terpyridine ruthenium chloride hexahydrate.

10. An integrated device, characterized in that, The device includes a protective housing and a phototherapy system based on a light-emitting synaptic transistor as described in any one of claims 1 to 9. The phototherapy system based on a light-emitting synaptic transistor is disposed inside the protective housing. The physiological signal acquisition module and the phototherapy module are in close contact with the user. The physiological signal acquisition module is used to detect the user's physiological signals. The phototherapy module is used to perform internal calculations in the phototherapy mode and to output therapeutic light in the phototherapy mode.

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