A micro-implant anchorage device with antibacterial and anti-inflammatory effects

Abstract

The application discloses a kind of micro-implant anchorage devices with antibacterial and anti-inflammatory effects, belonging to the field of oral orthodontic medical instruments.The device is made of TiZrCu alloy, wherein metal Zr is used to improve mechanical strength and biocompatibility, and metal Cu is used to provide broad-spectrum antibacterial properties and promote osteogenesis.The device has 99% antibacterial effect on Staphylococcus aureus and Escherichia coli, 90%-99% antibacterial effect on Streptococcus mutans and Pseudomonas gingivalis, and can effectively inhibit the formation of bacterial biofilm.The device structure includes a head, a working part, a tissue blocking ring part, a neck and a retention part, which are integrally formed by machining.The application significantly improves the antibacterial and anti-inflammatory capacity of micro-implant anchorage while maintaining excellent mechanical strength, effectively reduces local infection and surrounding inflammation, reduces the device shedding rate, and improves the success rate of orthodontic treatment.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and more specifically, to a micro-implant anchorage device with antibacterial and anti-inflammatory effects for orthodontic treatment. Background Technology

[0002] Mini-implant anchorage devices, as a key component in orthodontic treatment, provide absolute anchorage, significantly improving the correction of complex malocclusions. However, after implantation, bacterial colonization and infection are highly likely at the gingival perforation site at the neck and the interface between the retention site and bone tissue, leading to peri-implant mucositis or even peri-implantitis. This can cause bone resorption, device loosening, or even detachment, severely impacting the progress and success rate of orthodontic treatment. Statistics show that the incidence of peri-implantitis in mini-implant anchorage devices can reach 10%–30%, making it one of the main causes of early failure.

[0003] Currently, clinically used micro-implants primarily utilize titanium (Ti) and its alloys (such as Ti-6Al-4V). These materials offer advantages in biocompatibility, corrosion resistance, and mechanical strength, but all lack anti-infection properties. In particular, the vanadium (V) element in the Ti-6Al-4V alloy has potential cytotoxicity, which may inhibit cell growth and induce oxidative stress, adversely affecting the long-term stability of micro-implants.

[0004] To address the aforementioned issues, existing technologies have attempted to impart antibacterial properties to micro-implants through surface coating techniques, such as silver-loaded coatings, antimicrobial peptide coatings, or antibiotic coatings. However, these surface modification methods have significant drawbacks: insufficient bonding strength between the coating and the substrate, leading to easy peeling off during implantation due to friction or torque, resulting in rapid loss of antibacterial properties; simultaneously, the antibacterial components released from the coating may exhibit uncontrollable burst release effects, causing local cytotoxicity and hindering bone integration. Therefore, developing novel medical metallic materials with bulk antibacterial and anti-inflammatory properties based on existing materials, thereby endowing micro-implants with long-lasting and stable anti-infection capabilities from within the material rather than on the surface, is of great significance for improving the success rate of micro-implant anchorage implantation. Summary of the Invention

[0005] The purpose of this invention is to provide a micro-implant anchorage device with antibacterial and anti-inflammatory effects.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a micro-implant anchorage device with antibacterial and anti-inflammatory effects, the device being made entirely of TiZrCu alloy.

[0007] In the micro-implant anchorage device of the present invention, the metallic Zr added to the TiZrCu alloy is used to improve the mechanical strength and biocompatibility of the device; the added metallic Cu is used to promote the osteogenic process and provide broad-spectrum antibacterial properties.

[0008] Preferably, the TiZrCu alloy has 99% antibacterial activity against Staphylococcus aureus and Escherichia coli, and 90%-99% antibacterial activity against oral bacteria such as Streptococcus mutans and Pseudomonas gingivalis, and can effectively inhibit the formation of bacterial biofilms.

[0009] In the technical solution described in this invention, the micro-implant anchorage device is integrally machined and surface-polished using a high-precision Swiss-type CNC lathe, and its structure includes, in sequence: The head is a regular hexagonal prism with a smooth surface, used to engage with a special tool to hold the device. The head groove is a groove that runs through the center of the head and is used to connect and fix the orthodontic archwire.

[0010] The neck is a cylinder that is thinner than the head and has a smooth surface. It is used for elastic traction or to connect orthodontic archwires. The soft tissue blocking ring has a frustum structure and a smooth surface. It is used to block gingival tissue, prevent gingival hyperplasia, and determine the implantation depth. The smooth part of the screw body is cylindrical with a smooth surface, and is used to penetrate the gingival tissue after implantation; The threaded part of the nail body is a conical cylinder with self-tapping threads engraved on the surface, used for implantation into the jawbone or alveolar bone to enhance retention.

[0011] The head, neck, soft tissue blocking ring, smooth nail body, and threaded nail body are all integral structures formed from TiZrCu alloy material.

[0012] Beneficial Effects: By introducing Cu, this invention enables the device to achieve an antibacterial rate of 90%-99% against various oral pathogens and effectively inhibit the formation of bacterial biofilms, thereby significantly reducing local infection and surrounding inflammation, and lowering the device dislodgement rate. The addition of Zr significantly improves the mechanical strength of the device while maintaining excellent biocompatibility, reducing the risk of breakage due to excessive torque during implantation. The addition of Cu significantly promotes osteogenesis, facilitating the integration of the micro-implant with bone tissue and improving initial implantation stability and long-term survival rate. Attached Figure Description

[0013] Figure 1 This is a schematic diagram of the overall structure of the micro-implant anchorage device of the present invention; Reference numerals: 1. Head; 2. Head groove; 3. Neck; 4. Soft tissue blocking ring; 5. Smooth part of the nail body; 6. Threaded part of the nail body. Detailed Implementation

[0014] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention. Example

[0015] This embodiment provides a micro-implant anchorage device with antibacterial and anti-inflammatory effects, and its preparation method is as follows: Alloy preparation: High-purity Ti (≥99.9%), Zr (≥99.9%), and Cu (≥99.9%) were used as raw materials. After weighing according to the target composition, they were smelted in a vacuum arc remelting furnace. To ensure compositional uniformity, the ingot underwent three repeated smelting processes. The ingot was then multi-directionally forged at 1100℃ to form a billet. The billet was placed in a box furnace at 1000℃ and held for 30 minutes to allow it to fully enter the β single-phase region, followed by rapid quenching in a 30wt.% NaCl aqueous solution. The quenched billet was then hot-rolled at 730℃, with a strain rate of 1 s⁻¹ and a true strain of 1.2 to prepare large-size plates, thus obtaining the TiZrCu alloy.

[0016] Device fabrication: The TiZrCu alloy plate was integrally machined using a high-precision Swiss-type CNC lathe, and the surface was polished to obtain a micro-implant anchorage device with the following structure: Head 1: It is a regular hexagonal prism with a diameter of 2.2mm and a height of 1.0mm, with smooth and rounded corners and a smooth surface.

[0017] Head Groove 2: A through groove with a width of 0.48 mm and a depth of 0.65 mm is cut into the head.

[0018] Neck 3: A cylinder with a diameter of 1.5 mm and a height of 0.8 mm, with a smooth surface.

[0019] Soft tissue blocking ring 4: It is a truncated cone with a diameter of 2.4 mm and a height of 0.4 mm, and its bottom transitions naturally with the smooth part of the nail body.

[0020] Smooth part 5 of the nail body: It is a cylinder with a diameter of 1.3mm and a height of 1.2mm, and has a smooth surface.

[0021] Threaded part 6 of the nail body: It is a conical cylinder with a diameter of 1.3mm and a height of 6.8mm. The surface is engraved with threads. The threads are self-tapping. The thread pitch is 0.6mm, the thread width is 0.25mm, and the surface is smooth.

[0022] The micro-implant anchorage device prepared in this embodiment is entirely composed of TiZrCu alloy. Testing showed that the device achieved an antibacterial rate of 99% against Staphylococcus aureus and Escherichia coli, and an antibacterial rate between 90% and 99% against Streptococcus mutans and Pseudomonas gingivalis, while effectively inhibiting the formation of bacterial biofilms.

[0023] Although the invention has been described above with reference to embodiments, various modifications can be made and components can be replaced with equivalents without departing from the scope of the invention. In particular, features in the embodiments disclosed herein can be combined in any way, provided there is no structural conflict. The lack of an exhaustive description of these combinations in this specification is merely for brevity and resource conservation. Therefore, the invention is not limited to the specific embodiments disclosed herein, but includes all technical solutions falling within the scope of the claims.

Claims

1. A micro-implant anchorage device with antibacterial and anti-inflammatory effects, characterized in that, The device is made entirely of TiZrCu alloy.

2. The micro-implant anchorage device with antibacterial and anti-inflammatory effects according to claim 1, characterized in that, The added Zr metal in the TiZrCu alloy is used to improve mechanical strength and biocompatibility, while the added Cu metal is used to provide broad-spectrum antibacterial properties and promote osteogenic formation.

3. The micro-implant anchorage device with antibacterial and anti-inflammatory effects according to claims 1-2, characterized in that, The TiZrCu alloy exhibits 99% antibacterial activity against Staphylococcus aureus and Escherichia coli, and 90%-99% antibacterial activity against specific oral bacteria such as Streptococcus mutans and Pseudomonas gingivalis. It can also effectively inhibit the formation of bacterial biofilms.

4. The micro-implant anchorage device with antibacterial and anti-inflammatory effects according to claim 1, characterized in that, The device is manufactured by integral machining and surface polishing on a high-precision Swiss-type CNC lathe, and its structure includes, in sequence: The head is a regular hexagonal prism with a smooth surface, used to clamp the device with a special tool. The head groove is a groove that runs through the center of the head and is used to connect and fix the orthodontic archwire. The neck is cylindrical with a smooth surface and is used for elastic traction and connection of orthodontic archwires. The soft tissue blocking ring has a frustum structure and a smooth surface. It is used to block gingival tissue, prevent gingival hyperplasia, and determine the implantation depth. The smooth part of the nail body is a cylinder with a diameter of 1.3 mm and a height of 1.2 mm, and the surface is smooth; The threaded part of the nail body is a conical cylinder with self-tapping threads engraved on the surface, used for implantation into the jawbone and alveolar bone to enhance retention.

5. The micro-implant anchorage device with antibacterial and anti-inflammatory effects according to claim 4, characterized in that, The head is a regular hexagonal prism with a diameter of 2.2 mm and a height of 1.0 mm; the center of the head has a groove that is 0.48 mm wide and 0.65 mm deep, penetrating the head; the neck is a cylinder with a diameter of 1.5 mm and a height of 0.8 mm; the soft tissue blocking ring is a frustum with an upper diameter of 2.4 mm and a height of 0.4 mm; the smooth part of the nail body is a cylinder with a diameter of 1.3 mm and a height of 1.2 mm; the threaded part of the nail body is a conical cylinder with a diameter of 1.3 mm and a height of 6.8 mm, a thread pitch of 0.6 mm, a thread cutting edge width of 0.25 mm, and gradually tapers to a cone shape at the end.

Images